Three-dimensional structure of isoprene synthase and its use thereof for generating variants

ABSTRACT

The present invention provides a three-dimensional structures of  P. tremuloides  isoprene synthase and  P. alba  isoprene synthase. The invention also provides methods of using the three-dimensional structure to design isoprene synthases with improved activity for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.

CROSS-REFERENCE TO RELATED APPLICATIONS

This applications claims the benefit of U.S. Provisional patent application 61/172,199, filed on Apr. 23, 2009, and U.S. Provisional patent application 61/255,831, filed on Oct. 28, 2009, the contents of both are hereby incorporated by reference in its entirety.

FIELD OF INVENTION

The present invention is related to the crystallization and three-dimensional structure determination of Populus tremuloides isoprene synthase and Populus alba isoprene synthase. The invention also provides methods of producing variants of isoprene synthase for increased isoprene production in microbial host cells.

BACKGROUND OF THE INVENTION

Isoprenoids are isoprene polymers that find use in pharmaceuticals, neutraceuticals, flavors, fragrances, and rubber products. Natural isoprenoid supplies, however, are limited due to ecological concerns. For this reason, and to provide isoprenoid compositions having fewer impurities and greater uniformity, isoprenoids such as rubber are often produced synthetically.

Isoprene (2-methyl-1,3-butadiene) is a volatile hydrocarbon that is insoluble in water and soluble in alcohol. Commercially viable quantities of isoprene can be obtained by direct isolation from petroleum C5 cracking fractions or by dehydration of C5 isoalkanes or isoalkenes (Weissermel and Arpe, Industrial Organic Chemistry, 4th ed., Wiley-VCH, pp. 117-122, 2003). The C5 skeleton can also be synthesized from smaller subunits. It would be desirable, however, to have a commercially viable method of producing isoprene that was independent of nonrenewable resources.

Biosynthetic production of isoprene occurs by two distinct metabolic pathways (Julsing et al., Appl Microbiol Biotechnol, 75:1377-1384, 2007). In eukaryotes and archae, isoprene is formed via the mevalonate (MVA) pathway, while some eubacteria and higher plants produce isoprene via the methylerythritol phosphate (MEP) pathway. Isoprene emissions from plants are light and temperature-dependent with increases linked to leaf development. An isoprene-producing enzyme, isoprene synthase, has been identified in Aspen trees (Silver and Fall, Plant Physiol, 97:1588-1591, 1991; and Silver and Fall, J Biol Chem, 270:13010-13016, 1995) and is believed to be responsible for the in vivo production of isoprene from whole leaves. Bacterial production of isoprene has also been described (Kuzma et al., Curr Microbiol, 30:97-103, 1995; and Wilkins, Chemosphere, 32:1427-1434, 1996), and varies in amount with the phase of bacterial growth and the nutrient content of the culture medium (U.S. Pat. No. 5,849,970 to Fall et al.; and Wagner et al., J Bacteriol, 181:4700-4703, 1999, both herein incorporated by reference in their entirety). The levels of isoprene obtainable through bacterial systems of the prior art, however, are insufficient for commercial uses.

Polypeptides, e.g. isoprene synthase, have a three-dimensional structure determined by the primary amino acid sequence and the environment surrounding the polypeptide. This three-dimensional structure establishes the polypeptide's activity, stability, binding affinity, binding specificity, and other biochemical attributes. Thus, knowledge of a protein's three-dimensional structure can provide much guidance in designing improvements to its biological activity, for example, greater catalytic activity, dimerization and/or solubility.

The three-dimensional structure of a polypeptide can be determined in a number of ways. Many of the most precise methods employ X-ray crystallography (See, e.g., Van Holde, (1971) Physical Biochemistry, Prentice-Hall, New Jersey, pp. 221-39). This technique relies on the ability of crystalline lattices to diffract X-rays or other forms of radiation. Diffraction experiments suitable for determining the three-dimensional structure of macromolecules typically require high-quality crystals. The crystallization properties of a polypeptide vary greatly (Dale, et al., J. Struct. Biol. 142:88-97, 2003; MacPherson, A., Methods 34:254-265, 2004; and Slabinski, L et al., Protein Science 16:2472-2482, 2007). In some cases polypeptides crystallize readily whereas in other cases polypeptides have proven extremely difficult to obtain. There is no comprehensive theory to guide efforts to crystallize macromolecules and as a result, most efforts macromolecular crystal growth is empirical in nature (MacPherson, 2004).

Previous efforts to utilize the structure of isoprene synthase in order to improve production of isoprene have relied on the structures of other terpene synthases in which three-dimensional structures are available including bornyl diphosphate synthase and 5-epi-aristolochene synthase (See e.g., U.S. patent application Ser. No. 12/429,143 and WO 2008/137092). What is needed is a three-dimensional structure of isoprene synthase to aid in the design of variants of isoprene synthase to allow commercial scale biological production of isoprenoids.

A three-dimensional structure of isoprene synthase is found to have a structurally homologous fold with previously determined synthetases, e.g. bornyl diphosphate synthase and limonene synthase, including conservation in the region involved with the coordinates of required metal ion cofactors, the active and substrate binding sites. The structure has provided insight in the conformational changes that are necessary for these enzyme to bind substrate and catalyze a coordinated series of reactions. Specifically the structure has identified flexible regions that are likely to be shared by all structurally homologous synthetase and that modification of the amino acids found in these regions and the neighboring regions would be expected to effect improved performance of these enzymes. A three-dimensional structure of isoprene synthase may provide a three-dimensional configuration of points, or reaction coordinates, representing the active site of isoprene synthase for the conversion of dimethylallyl diphosphate (DMAPP) into isoprene. Such a configuration of points can aid in the design of synthetic agents for the conversion of DMAPP into isoprene.

BRIEF SUMMARY OF THE INVENTION

The invention provides methods and compositions for generating variants of isoprene synthase with improved activity, expression or stability by utilizing three dimensional structure of isoprene synthase. In one aspect, the invention provides a) using a three dimensional structure of isoprene synthase to identify at least one location in the isoprene synthase for amino acid substitutions that is capable of increasing the activity, expression or stability of isoprene synthase; and b) modifying the isoprene synthase at the location(s) to generate an isoprene synthase variant with improved activity, expression or stability. In one embodiment, the location is selected from the group consisting of: flexible loop, disphosphate/metal binding site, active site, isoprenyl binding site, surface region, negatively charged region, hinge region, and electrostatic patch region.

In another aspect, the invention provides for methods of generating a variant of an isoprene synthase with improved activity, expression or stability; the method comprising; a) identifying hydrophobic amino acid residues on the surface of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the surface amino acids of isoprene synthase; c) identifying variants with substitutions that improve activity, expression or stability of the isoprene synthase compared to the P. alba isoprene synthase amino acid sequence of SEQ ID NO:45. In some embodiments, the hydrophobic surface amino acid is selected from the group consisting of I28, V30, L130, G153, L303, L469 and L494.

In other aspects, the invention provides for an isoprene synthase variant produced any of the methods disclosed herein. In some aspects, the isoprene synthase variant is isolated.

In other aspects, the isoprene synthase variant comprises one or more substitution(s) selected from the group consisting of I28W, I28T, I28R, I28Y, V30K, L130W, L130K, L1305, L130Y, L130R, L130V, L130I, L130E, L130D, G153K, G153H, G153L, G153W, L3031, L469A, L469Q, L494P, L494C, L494I, L494V, L494S, L494G, and L494D.

In other aspects, the invention provides for isoprene synthase variant, wherein the variant comprises one or more substitution(s) of a hydrophobic surface amino acid selected from the group consisting of I28, V30, L130, G153, L303, L469 and L494. In some aspects, the mutation is selected from the group consisting of I28W, I28T, I28R, I28Y, V30K, L130W, L130K, L1305, L130Y, L130R, L130V, L130I, L130E, L130D, G153K, G153H, G153L, G153W, L3031, L469A, L469Q, L494P, L494C, L494I, L494V, L494S, L494G, and L494D.

In other aspects, the invention provides for any host cell comprising the nucleic acid encoding for any of the isoprene synthase variants disclosed herein. The invention also provides for host cells that express or are capable of expressing any of the isoprene synthase variants disclosed herein.

In other aspects, the invention provides for methods of generating a variant of an isoprene synthase with improved activity, expression or stability; the method comprising; a) identifying residues in the hinge region of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the hinge region amino acids of isoprene synthase; c) identifying variants with substitutions that improve activity, expression or stability of the isoprene synthase compared to the P. alba isoprene synthase amino acid sequence of SEQ ID NO:45. In some embodiments, the hinge region amino acid is selected from the group consisting of R198, I229 and L260.

In other aspects, the invention provides for an isolated isoprene synthase variant, wherein the variant comprises one or more substitution(s) in a hinge region amino acid selected from the group consisting of R198, I229 and L260. In other aspects, the invention provides for variants comprising one or more substitution(s) selected from the group consisting of I229V, I229L, I229C, I229T, I229P, I229N, L260N, L260M, and L260I.

In other aspects, the invention provides for methods of generating a variant of an isoprene synthase with improved activity, expression or stability; the method comprising; a) identifying amino acid residues in the negatively charged area of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the negatively charged area amino acids of isoprene synthase; c) identifying variants with substitutions that improve activity, expression or stability of the isoprene synthase compared to the P. alba isoprene synthase amino acid sequence of SEQ ID NO:45. In some embodiments, the negatively charged area amino acid is selected from the group consisting of D311 and D323. In some embodiments, the variant comprises one or more substitution(s) selected from the group consisting of D311M, D311F, D311L, D311G, D311I, D311A, D311T, D311R, D311V, D311E, D323M, D323W, D323Y, D323F, D323I, D323S, D323V, D323A, D323G, and D323Q.

In other aspects, the invention provides for an isoprene synthase variant, wherein the wherein the variant comprises one or more substitution(s) in a negatively charged area amino acid selected from the group consisting of D311 and D323.

In other aspects, the invention provides for methods of generating a variant of an isoprene synthase with improved activity, expression or stability; the method comprising; a) identifying amino acid residues in the flexible loops of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the flexible loop amino acids of isoprene synthase; and c) identifying variants with substitutions that improve activity, expression or stability of the isoprene synthase compared to the P. alba isoprene synthase amino acid sequence of SEQ ID NO:45. In some embodiments, the flexible loop amino acid is selected from the group consisting of A443, A453, N454, H515 and A519. In other embodiments, the variant comprises one or more substitution(s) selected from the group consisting of A443S, A443G, A443R, A443Q, A453L, A453N, A453I, A453V, H515M, H515Q, A519H, A519S, A519G, A519W and A519T.

In other aspects, the invention provides for an isoprene synthase variant, wherein the variant comprises one or more substitution(s) in a flexible loop amino acid selected from the group consisting of A443, A453, N454, H515 and A519. In some embodiments, the variant is substituted at amino acid T536. In other embodiments, the variant comprises one or more substitution(s) selected from the group consisting of T536F, T536Y, T536V, T536I, T536M, T536H, T536C, T536L, T536K, T536A, T536S and T536G.

In other aspects, the invention provides for methods of generating a variant of an isoprene synthase with improved activity, expression or stability; the method comprising; a) identifying amino acid residues in the diphosphate/metal binding site of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the diphosphate/metal binding site amino acids of isoprene synthase; and c) identifying variants with substitutions that improve activity, expression or stability of the isoprene synthase compared to the P. alba isoprene synthase amino acid sequence of SEQ ID NO:45.

In other aspects, the invention provides for isoprene synthase variants, wherein the variant comprises one or more substitution(s) in a diphosphate/metal binding site amino acid.

In other aspects, the invention provides for methods of generating a variant of an isoprene synthase with improved activity, expression or stability; the method comprising; a) identifying amino acid residues in the isoprenyl binding site of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the isoprenyl binding site amino acids of isoprene synthase; and c) identifying variants with substitutions that improve activity, expression or stability of the isoprene synthase compared to the P. alba isoprene synthase amino acid sequence of SEQ ID NO:45).

In other aspects, the invention provides for isoprene synthase variants, wherein the variant comprises one or more substitution(s) in a isoprenyl binding site amino acid.

In other aspects, the invention provides for methods of producing isoprene, comprising: (a) providing a host cell of any one of claims 9, 15, 21, 27, 30, 34, and 38; and (b) culturing the host cell under conditions suitable for producing isoprene.

The invention provides methods of generating a variant of an isoprene synthase with improved activity, expression or stability comprising; a) identifying amino acid residues on the surface of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the surface amino acids of isoprene synthase; c) identifying mutations that improve activity, expression or stability of the isoprene synthase compared to the P. alba isoprene synthase comprising the amino acid sequence of SEQ ID NO: 18. In some embodiments, the amino acid substitutions include one or more of the following: hydrophobic to positively charged, positively charged to hydrophobic, hydrophobic to negatively charged, negatively charged to hydrophobic, hydrophobic to neutral polar, neutral polar to hydrophobic, neutral polar to positively charged, positively charged to neutral polar, neutral polar to negatively charged, negatively charged to neutral polar, positively charged to negatively charged, and negatively charged to positively charged.

The invention provides methods for generating a variant of an isoprene synthase with improved activity comprising a) identifying amino acid residues in or near the diphosphate/metal binding site in the three dimensional structure of P. tremuloides isoprene synthase; b) introducing one or more amino acid substitutions in or near the diphosphate/metal binding site of isoprene synthase; c) identifying mutations that improve the activity of the isoprene synthase compared to the P. tremuloides isoprene synthase comprising the amino acid sequence of SEQ ID NO:11. In some embodiments the invention provides an isolated isoprene synthase variant produced by these methods. In some embodiments, the amino acids in the diphosphate/metal binding site are selected from the group consisting of D293, Y385, S392 and D437.

The invention provides methods of generating a variant of an isoprene synthase with improved activity comprising a) identifying amino acid residues in the isoprenyl binding site in the three dimensional structure of P. tremuloides isoprene synthase; b) introducing one or more amino acid substitutions in the isoprenyl binding site of isoprene synthase; c) identifying mutations that improve the activity of the isoprene synthase compared to the P. tremuloides isoprene synthase comprising the amino acid sequence of SEQ ID NO:11. In some embodiments the invention provides an isolated isoprene synthase variant produced by this method. In some embodiments, the amino acids in the isoprenyl binding site are selected from the group consisting of S261, W264, F285, T289, S393, S394, F432 and Y512.

The invention provides methods of generating a variant of an isoprene synthase with improved activity comprising a) identifying amino acid residues in the substrate access loop in the three dimensional structure of P. tremuloides isoprene synthase; b) introducing one or more amino acid substitutions in the substrate access loop of isoprene synthase; c) identifying mutations that improve the activity of the isoprene synthase compared to the P. tremuloides isoprene synthase comprising the amino acid sequence of SEQ ID NO:11. In some embodiments the invention provides an isolated isoprene synthase variant produced by these methods. In some embodiments the amino acids in the substrate access loop are selected from the group consisting of S440, A441, S442, A443, E444, I445, A446, R447, G448, E449, T450, A451, N452, S453, Y512, H513, N514, G515, D516, A517, H518, T519, S520, P521, D522, E523, and L524.

The invention provides a variant of a parent synthase that is structurally homologous to isoprene synthase and having modified residues corresponding to or analogous to the following residues of the flexible N-terminus and/or adjacent residues; 1-28, 239, 243, 253-257, 259, 260, 293, 295-300, 303, 325, 374 of an isoprene synthase. In some embodiments, the synthase is an isoprene synthase. In some embodiments, the invention provides a variant of a parent synthase that is structurally homologous to isoprene synthase and having modified residues corresponding to or analogous to the following residues of the flexible loop I and/or adjacent residues; 438-453, 293, 295, 297, 370, 371, 373, 374, 378-380, 382, 385, 386, 433-437, 454-458, 469, 472, 476, 512 of isoprene synthase. In some embodiments, the synthase is an isoprene synthase. In some embodiments, the invention provides a variant of a parent synthase that is structurally homologous to isoprene synthase and having modified residues corresponding to or analogous to the following residues of the flexible loop II and/or adjacent residues; 512-526, 187, 188, 255, 257, 270, 271, 273, 274, 285, 288, 439, 440, 442, 508-512, and 528-532 of isoprene synthase the synthase is an isoprene synthase.

The invention provides methods of generating a variant of a parent terpene synthase or terpene synthase structural homolog with improved activity comprising a) identifying amino acid residues in or near one or more substrate access loops in the three dimensional structure of the terpene synthase or terpene synthase structural homolog, b) introducing one or more amino acid substitutions in or near the one or more substrate access loops of the terpene synthase or terpene synthase structural homolog, c) identifying substitutions that improve the activity of the terpene synthase or terpene synthase structural homolog variant compared to the parent terpene synthase or terpene synthase structural homolog. In some embodiments, the terpene synthase or terpene synthase structural homolog is an isoprene synthase. In some embodiments, the isoprene synthase is P. tremuloides isoprene synthase comprising SEQ ID NO:11. In some embodiments, the isoprene synthase is P. alba isoprene synthase comprising SEQ ID NO: 18. In some embodiments, the variant comprises a substitution of one or more of the following amino acid residues L17, L18, S19, S20, S239, R243, F253, A254, R255, D256, R257, I259, E260, D293, Y295, D296, V297, Y298, G299, T300, E303, Y325, L374, Y375, V529, L530, T534, D293, Y295, V297, E370, A371, W373, L374, S378, T379, P380, F382, Y385, F386, R433, L434 C435, N436, D437, V454, S455, C456, Y457, M458, T469, V472, I476, Y512, E187, L188, R255, R257, F270, E271, Q273, Y274, F285, V288, A439, S440, S442, S508, H509, C510, T511, Y512, R528, V529, L530, S531, and V532.

The invention provides methods of generating a variant of isoprene synthase by a) obtaining a crystal comprising an isoprene synthase; b) obtaining the atomic coordinates of the crystal; c) correlating the atomic coordinate data with one or more molecular modeling techniques; d) identifying at least one modification predicted to effect the activity, expression or stability of isoprene synthase; and e) modifying the isoprene synthase based on the prediction. In some embodiments, the isoprene synthase is P. tremuloides isoprene synthase. In some embodiments, the isoprene synthase is a P. alba isoprene synthase.

In some aspects, the invention provides methods of generating a variant of an isoprene synthase comprising a) correlating the atomic coordinate data for P. tremuloides isoprene synthesis of Table 3-7 with one of more molecular modeling techniques b) identifying at least one modification predicted to effect the activity, expression or stability of isoprene synthase; and c) modifying the isoprene synthase based on the prediction obtained in b).

In some aspects, the invention provides methods of generating a variant of an isoprene synthase comprising a) correlating the atomic coordinate data for P. alba isoprene synthesis of Table 4-2 with one of more molecular modeling techniques b) identifying at least one modification predicted to effect the activity, expression or stability of isoprene synthase; and c) modifying the isoprene synthase based on the prediction obtained in b).

In other aspects, the invention provides methods of identifying a candidate variant of an isoprene synthase comprising: a) comparing the atomic structure of the isoprene synthase without a bound ligand to the atomic structure of the isoprene synthase with a bound ligand, and b) computationally identifying candidate variants of the isoprene synthesis for the ability to bind the ligand.

The invention provides methods of generating a variant of an isoprene synthase with improved activity, expression or stability comprising; a) identifying amino acid residues on the surface of isoprene synthase based on the three dimensional structure of P. tremuloides isoprene synthase; b) introducing one or more amino acid substitutions in the surface amino acids of isoprene synthase; c) identifying mutations that improve activity, expression or stability of the isoprene synthase compared to the P. tremuloides isoprene synthase comprising the amino acid sequence of SEQ ID NO: 11. In some embodiments, the amino acid substitutions include one or more of the following: hydrophobic to positively charged, positively charged to hydrophobic, hydrophobic to negatively charged, negatively charged to hydrophobic, hydrophobic to neutral polar, neutral polar to hydrophobic, neutral polar to positively charged, positively charged to neutral polar, neutral polar to negatively charged, negatively charged to neutral polar, positively charged to negatively charged, and negatively charged to positively charged.

The invention provides methods of generating variants of an isoprene synthase with improved activity, expression or stability by a) identifying hydrophobic amino acid residues on the surface of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the surface amino acids of isoprene synthase; c) identifying mutations that improve activity, expression or stability of the isoprene synthase compared to the parent P. alba isoprene synthase.

The invention provides isolated P. alba isoprene synthase variants comprising a mutation of a hydrophobic surface amino acid at one or more of the following residues: I28, V30, L130, G153, L303, L469 and L494. In some embodiments, the variant comprises one or more of the following mutations: I28W, I28T, I28R, I28Y, V30K, L130W, L130K, L1305, L130Y, L130R, L130V, L1301, L130E, L130D, G153K, G153H, G153L, G153W, L3031, L469A, L469Q, L494P, L494C, L494I, L494V, L494S, L494G, and L494D.

The invention provides methods of generating variants of a parent isoprene synthase with improved activity, expression or stability by a) identifying residues in the hinge region of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the hinge region amino acids of isoprene synthase; c) identifying mutations that improve activity, expression or stability of the isoprene synthase compared to the parent P. alba isoprene synthase.

In some aspects, the invention provides isolated P. alba isoprene synthase variants comprising a mutation in or near a hinge region wherein the variant comprises a mutation at one or more of the following residues R198, I229 and L260. In some embodiments, the variant comprises one or more of the following mutations: I229V, I229L, I229C, I229T, I229P, I229N, L260N, L260M, and L260I.

The invention provides methods of generating variants of an isoprene synthase with improved activity, expression or stability by a) identifying amino acid residues in the electrostatic patch of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the electrostatic patch amino acids of isoprene synthase; c) identifying mutations that improve activity, expression or stability of the isoprene synthase compared to the parent P. alba isoprene synthase.

In some aspects, the invention provides isolated P. alba isoprene synthase variants, wherein the wherein the variant comprises a mutation in an electrostatic patch amino acid including, but not limited to residues D311 and D323. In some embodiments, the variant comprises one or more of the following mutations: D311M, D311F, D311L, D311G, D311I, D311A, D311T, D311R, D311V, D311E, D323M, D323W, D323Y, D323F, D323I, D323S, D323V, D323A, D323G, and D323Q.

The invention provides methods of generating variants of an isoprene synthase with improved activity, expression or stability by a) identifying amino acid residues in the flexible loops of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the flexible loop amino acids of isoprene synthase; c) identifying mutations that improve activity, expression or stability of the isoprene synthase compared to the parent P. alba isoprene synthase.

The invention provides isolated P. alba isoprene synthase variants comprises a mutation in a flexible loop at one or more of the following residues: A443, A453, N454, H515, A519 and E525. In some embodiments, the variant comprises one or more of the following mutations: A443S, A443G, A443R, A443Q, A453L, A453N, A453I, A453V, H515M, H515Q, A519H, A519S, A519G, A519W and A519T.

In some aspects, the invention provides isolated P. alba isoprene synthase variants mutated at amino acid T536. In some embodiments, the variant comprises one of the following mutations: T536F, T536Y, T536V, T536I, T536M, T536H, T536C, T536L, T536K, T536A, T536S and T536G.

The invention provides methods of generating variants of an isoprene synthase with improved activity, expression or stability; the method comprising; a) identifying amino acid residues in the diphosphate/metal binding site of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the diphosphate/metal binding site amino acids of isoprene synthase; c) identifying mutations that improve activity, expression or stability of the isoprene synthase compared to the parent P. alba isoprene synthase. In some aspects, the invention provides isolated isoprene synthase variants, comprising a mutation in a diphosphate/metal binding site residue of P. alba isoprene synthase.

The invention provides methods of generating variants of an isoprene synthase with improved activity, expression or stability; the method comprising a) identifying amino acid residues in the isoprenyl binding site of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the isoprenyl binding site amino acids of isoprene synthase; c) identifying mutations that improve activity, expression or stability of the isoprene synthase compared to the parent P. alba isoprene synthase. In some aspects, the invention provides isolated P. alba isoprene synthase variants comprises a mutation in a isoprenyl binding site amino acid.

In another aspect, the invention provides a crystalline form of an isoprene synthase. In particular, the invention provides methods of improving the activity of a terpene synthase based on the crystalline form of isoprene synthase. In some embodiments, the crystalline form of the isoprene synthase further comprises a ligand, for example dimethylallyl pyrophosphate (DMAPP).

In some aspects, a crystalline form of P. tremuloides isoprene synthase comprises a structure characterized by tetragonal space group symmetry P4₃2₁2 and unit cell dimensions of a=154.2 angstroms, b=154.2 angstroms and c=142.7 angstroms and wherein the alpha=beta=gamma=90 degrees. In some embodiments, the unit cell dimensions are a=146.5 to 161.9 angstroms, b=146.5 to 161.9 angstroms and c=135.6 to 149.8 angstroms and wherein the alpha=beta=gamma=90 degrees.

In some aspects, a crystalline form of P. alba isoprene synthase comprises a structure characterized by tetragonal space group symmetry P4₃2₁2 and unit cell dimensions of a=156.8 angstroms, b=156.8 angstroms and c=142.5 angstroms and wherein the alpha=beta=gamma=90 degrees. In some embodiments, the unit cell dimensions are a=148.96 to 164.6 angstroms, b=148.96 to 164.6 angstroms and c=135.4 to 149.6 angstroms and wherein alpha=beta=gamma=90 degrees.

The invention provides a crystalline form of a polypeptide comprising a structure defined by one or more structure coordinates of P. tremuloides isoprene synthase amino acids Arg 255, Asp 292, Asp 296, Glu 370, Arg 433 and Asn436, Ser261, Trp264, Phe285, Thr289, Ser393, Phe432 and Tyr512 according to Table 3-7, or similar structural coordinates for said residues comprising a root mean square deviation of less than about 1.5 Å when superimposed on the non-hydrogen atom positions of the corresponding atomic coordinates of Table 3-7. In some embodiments, the root mean square deviation is less than about 0.75 Å when superimposed on the non-hydrogen atom positions of the corresponding atomic coordinates of Table 3-7. In some embodiments, the root mean square deviation is less than about 0.35 Å when superimposed on the non-hydrogen atom positions of the corresponding atomic coordinates of Table 3-7.

In some embodiments of the invention, the invention provides a crystalline form of a P. tremuloides isoprene synthase wherein amino acid residues Arg 255, Asp 292, Asp 296, Glu 370, Arg 433 and Asn 436 comprise the diphosphate/metal binding sites of the isoprene synthase. In some embodiments, amino acid residues Ser 261, Trp 264, Phe 285, Thr 289, Ser 393, Ser 394, Phe 432, and Try 512 comprise the isoprenyl binding site of the isoprene synthase. In some embodiments, amino acid residues 438-453 having the sequence SASAEIARGETANS (SEQ ID NO:40) and residues 512-526 having the sequence YHNGDAHTSPDEL (SEQ ID NO:41) comprise the substrate access loops of the isoprene synthase. In some embodiments, amino acids 1-16 and 17-28 comprise N-terminal loops designated N-terminal loop I and N-terminal loop II.

The invention provides a crystalline form of a polypeptide that comprises an amino acid sequence having at least 75% identity to SEQ ID NO:11. In some embodiments, the polypeptide comprises an amino acid sequence having at least 85% identity to SEQ ID NO:11. In other embodiments, the polypeptide comprises an amino acid sequence having at least 90% identity to SEQ ID NO:11.

The invention provides a crystalline form of a polypeptide that comprises an amino acid sequence having at least 75% identity to SEQ ID NO:18. In some embodiments, the polypeptide comprises an amino acid sequence having at least 85% identity to SEQ ID NO:18. In other embodiments, the polypeptide comprises an amino acid sequence having at least 90% identity to SEQ ID NO:11.

The invention provides a scalable three-dimensional configuration of points, at least a portion of said points derived from structure coordinates of at least a portion of a P. tremuloides isoprene synthase molecule or molecular complex listed in Table 3-7 and having a root mean square deviation of less than about 1.5 Å from said structure coordinates. In some embodiments, at least a portion of the points derived from the P. tremuloides isoprene synthase structure coordinates are derived from structure coordinates representing the locations of at least the backbone atoms of a plurality of the amino acids defining at least one P. tremuloides isoprene synthase or P. tremuloides isoprene synthase-like diphosphate/metal binding site comprising amino acids Arg 255, Asp 292, Asp 296, Glu 370, Arg 433 and Asn436. In some embodiments, at least a portion of the points derived from the P. tremuloides isoprene synthase structure coordinates are derived from structure coordinates representing the locations of at least the backbone atoms of a plurality of the amino acids defining at least one P. tremuloides isoprene synthase or P. tremuloides isoprene synthase-like isoprenyl binding site, the isoprenyl binding site comprising amino acids Ser 261, Trp 264, Phe 285, Thr 289, Ser 393, Ser 394, Phe 432, and Tyr 512. In other embodiments, at least a portion of the points derived from structure coordinates representing the locations of at least the backbone atoms of a plurality of the amino acids defining at least one P. tremuloides isoprene synthase or P. tremuloides isoprene synthase-like flexible loop including but not limited to Loop I amino acid residues 438-453 including the sequence SASAEIARGETANS (SEQ ID NO:40), residues 512-526 having the sequence YHNGDAHTSPDEL (SEQ ID NO:41), amino acids 1-16 forming N-terminal loop I amino acids 17-28 forming N-terminal loop II. In some embodiments, at least a portion of the points derived from the P. tremuloides isoprene synthase structure coordinates are derived from structure coordinates representing the locations of at least the backbone atoms of a plurality of the amino acids defining at least one P. tremuloides isoprene synthase or P. tremuloides isoprene synthase-like diphosphate/metal binding site, the diphosphate/metal binding site comprising amino acids Arg 255, Asp 292, Asp 296, Glu 370, Arg 433 and Asn436; and at least a portion of the points derived from the P. tremuloides isoprene synthase structure coordinates are derived from structure coordinates representing the locations of at least the backbone atoms of a plurality of the amino acids defining at least one P. tremuloides isoprene synthase or P. tremuloides isoprene synthase-like isoprenyl binding site, the isoprenyl binding site comprising amino acids Ser 261, Trp 264, Phe 285, Thr 289, Ser 393, Ser 394, Phe 432, and Try 512.

The invention provides a machine-readable medium embedded with information that corresponds to a three-dimensional structural representation of a crystalline form of a P. tremuloides isoprene synthase or of a P. alba isoprene synthase. Additionally, the invention provides a computer system comprising a database containing information on the three dimensional structure of a crystalline form of a P. tremuloides isoprene synthase or a P. alba isoprene synthase and a user interface to view the information. A figure showing the high structural homology between the two coordinate sets included is shown as a stereodisgram in FIG. 64.

The invention provides agents characterized by a three-dimensional configuration of points derived from structure coordinates of at least a portion of a P. tremuloides isoprene synthase molecule or molecular complex listed in Table 3-7 and having a root mean square deviation of less than about 1.5 Å from said structure coordinates. In some embodiments, agents are characterized by a three-dimensional configuration of points derived from structure coordinates representing the locations of at least the backbone atoms of a plurality of the amino acids defining at least one P. tremuloides isoprene synthase or P. tremuloides isoprene synthase-like diphosphate/metal binding site comprising amino acids Arg 255, Asp 292, Asp 296, Glu 370, Arg 433 and Asn436. In some embodiments, agents are characterized by at least a portion of the points derived from the P. tremuloides isoprene synthase structure coordinates are derived from structure coordinates representing the locations of at least the backbone atoms of a plurality of the amino acids defining at least one P. tremuloides isoprene synthase or P. tremuloides isoprene synthase-like isoprenyl binding site, the isoprenyl binding site comprising amino acids Ser 261, Trp 264, Phe 285, Thr 289, Ser 393, Ser 394, Phe 432, and Try 512. In other embodiments, agents are characterized by at least a portion of the points derived from structure coordinates representing the locations of at least the backbone atoms of a plurality of the amino acids defining at least one P. tremuloides isoprene synthase or P. tremuloides isoprene synthase-like flexible loop including but not limited to Loop I amino acid residues 438-453 including the sequence SASAEIARGETANS (SEQ ID NO:40), residues 512-526 having the sequence YHNGDAHTSPDEL (SEQ ID NO:41), amino acids 1-16 forming N-terminal loop I amino acids 17-28 forming N-terminal loop II.

The invention provides a scalable three-dimensional configuration of points, at least a portion of the points derived from structure coordinates of a P. alba isoprene synthase molecule or a molecular complex listed in Table 4-2 and having a root mean square deviation of less than about 1.5 Å from said structure coordinates. In some embodiments, at lease a portion of the points derived from the P. alba isoprene synthase structure coordinates are derived from structure coordinates representing the locations of at least the backbone atoms of a plurality of the amino acids defining at least one P. alba isoprene synthase or P. alba isoprene synthase-like sites, including but not limited to, a diphosphate/metal binding site, a isoprenyl binding site, a flexible loop, an electrostatic patch and a hinge region.

The invention provides agents characterized by a three-dimensional configuration of points derived from the structure coordinates of at lease a portion of a P. alba isoprene synthase molecule or molecular complex listed in Table 4-2 and having a root mean square deviation of less than about 1.5 Å from said structure coordinates. In some embodiments, agents are characterized by a three-dimensional configuration of points derived from the structural reaction coordinates representing the locations of at least the backbone atoms of a plurality of the amino acids defining at least one P. alba isoprene synthase or P. alba isoprene synthase-like of diphosphate/metal binding site, a flexible loop, an electrostatic patch and a hinge region.

The invention provides methods of producing isoprene by (a) providing a host cell comprising a P. alba isoprene synthase variant and (b) culturing the host cell under conditions suitable for producing isoprene.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows the MVA and DXP metabolic pathways for isoprene (based on F. Bouvier et al., Progress in Lipid Res. 44: 357-429, 2005). The following description includes alternative names for each polypeptide in the pathways and a reference that discloses an assay for measuring the activity of the indicated polypeptide (each of these references are each hereby incorporated by reference in their entireties, particularly with respect to assays for polypeptide activity for polypeptides in the MVA and DXP pathways). Mevalonate Pathway: AACT; Acetyl-CoA acetyltransferase, MvaE, EC 2.3.1.9. Assay: J. Bacteriol., 184: 2116-2122, 2002; HMGS; Hydroxymethylglutaryl-CoA synthase, MvaS, EC 2.3.3.10. Assay: J. Bacteriol., 184: 4065-4070, 2002; HMGR; 3-Hydroxy-3-methylglutaryl-CoA reductase, MvaE, EC 1.1.1.34. Assay: J. Bacteriol., 184: 2116-2122, 2002; MVK; Mevalonate kinase, ERG12, EC 2.7.1.36. Assay: Curr Genet. 19:9-14, 1991. PMK; Phosphomevalonate kinase, ERGS, EC 2.7.4.2, Assay: Mol Cell Biol., 11:620-631, 1991; DPMDC; Diphosphomevalonate decarboxylase, MVD1, EC 4.1.1.33. Assay: Biochemistry, 33:13355-13362, 1994; IDI; Isopentenyl-diphosphate delta-isomerase, IDI1, EC 5.3.3.2. Assay: J. Biol. Chem. 264:19169-19175, 1989. DXP Pathway: DXS; 1-Deoxyxylulose-5-phosphate synthase, dxs, EC 2.2.1.7. Assay: PNAS, 94:12857-62, 1997; DXR; 1-Deoxy-D-xylulose 5-phosphate reductoisomerase, dxr, EC 2.2.1.7. Assay: Eur. J. Biochem. 269:4446-4457, 2002; MCT; 4-Diphosphocytidyl-2C-methyl-D-erythritol synthase, IspD, EC 2.7.7.60. Assay: PNAS, 97: 6451-6456, 2000; CMK; 4-Diphosphocytidyl-2-C-methyl-D-erythritol kinase, IspE, EC 2.7.1.148. Assay: PNAS, 97:1062-1067, 2000; MCS; 2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase, IspF, EC 4.6.1.12. Assay: PNAS, 96:11758-11763, 1999; HDS; 1-Hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase, ispG, EC 1.17.4.3. Assay: J. Org. Chem., 70:9168-9174, 2005; HDR; 1-Hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, IspH, EC 1.17.1.2. Assay: JACS, 126:12847-12855, 2004.

FIG. 2 provides a map of plasmid p9795.

FIG. 3 (3A, B) provides the nucleotide sequence (SEQ ID NO:1) of plasmid p9795.

FIG. 4 provides a map of plasmid pTrcKudzu.

FIG. 5 (5A, B, C) provides the nucleotide sequence (SEQ ID NO:2) of plasmid pTrcKudzu.

FIG. 6 provides a map of plasmid pMAL-C4X.

FIG. 7 (7A, B, C) provides the nucleotide sequence (SEQ ID NO:3) of plasmid pMAL-C4X.

FIG. 8 provides a map of plasmid pMAL-C4X-Kudzu.

FIG. 9 (9A, B, C, D) provide the nucleotide sequence (SEQ ID NO:4) of pMAL-C4X-Kudzu.

FIG. 10 provides maps of pET24 P. tremuloides and pET24 P. trichocarpa.

FIG. 11 provides the amino acid Sequence (SEQ ID NO:5) of P. tremuloides IspS in P. tremuloides pET24a.

FIG. 12 (12A, B, C) provides the nucleotide sequence (SEQ ID NO:6) of plasmid P. tremuloides pET24.

FIG. 13 provides the amino acid sequence (SEQ ID NO:7) of P. trichocarpa IspS in P. trichocarpa pET24a.

FIG. 14 (14A, B, C) provides the nucleotide sequence (SEQ ID NO:8) of plasmid P. trichocarpa pET24.

FIG. 15A provides the map of plasmids pDu30.

FIG. 15B provides the map of plasmids pDu31.

FIG. 15C provides the map of plasmids pDu32.

FIG. 16 provides the amino acid sequence (SEQ ID NO:9) of the P. alba IspS variant in pDu30.

FIG. 17 (17A, B, C) provides the nucleotide sequence (SEQ ID NO:10) of plasmid pDu30.

FIG. 18 provides the amino acid sequence (SEQ ID NO:11) of the P. tremuloides IspS variant in pDu31. The numbering convention for purposes of describing the three-dimensional structure of isoprene synthase is such that the first number of the complete sequence containing the tag is −35, with the first three residues of IspS being MRR (underlined).

FIG. 19 (19A, B, C) provides the nucleotide sequence (SEQ ID NO:12) of plasmid pDu31.

FIG. 20 provides the amino acid sequence (SEQ ID NO:13) of the P. trichocarpa IspS variant in pDu32.

FIG. 21 (21A, B, C) provides the nucleotide sequence (SEQ ID NO:14) of plasmid pDu32.

FIG. 22 (22A, B, C) provides the nucleotide sequence (SEQ ID NO:15) of plasmid pDu27.

FIG. 23 provides the amino acid sequence (SEQ ID NO:16) of full length P. alba IspS in P. alba pET24a.

FIG. 24 (24A, B, C) provides the nucleotide sequence of sequence (SEQ ID NO:17) of P. alba pET24a.

FIG. 25 provides the maps of plasmids MD09-161 and MD09-163.

FIG. 26 provides amino acid sequence (SEQ ID NO:18) of P. alba MEA(+)TEV in MD09-163.

FIG. 27 (A, B, C) provides the nucleotide sequence (SEQ ID NO:19) of plasmid MD09-163. The CDS is underlined and the TEV protease site is bold.

FIG. 28 provides the amino acid sequence (SEQ ID NO:20) of P. alba FL (+) TEV in MD09-161.

FIG. 29 (29A, B, C) provides the nucleotide sequence (SEQ ID NO:21) of MD09-161. The CDS is underlined and the TEV protease site is bold.

FIG. 30 provides the three-dimensional structure of P. tremuloides IspS shown as a dimer. Chain A is in dark gray, chain B is in medium gray and the single magnesium ion found in each active site is light gray.

FIG. 31 provides a monomer view of the structure of P. tremuloides IspS. The magnesium is shown as a light gray sphere and the N- and C-terminals are indicated.

FIG. 32 shows the structural alignments between (A) BdpS and LS, (B) BdpS and P. tremuloides IspS, (C) LS and P. tremuloides IspS, and (D) TEAS and P. tremuloides IspS. In each case the first structure is in light gray and the second is in dark gray. Divalent cations are shown as spheres.

FIG. 33 shows the three dimensional structure of loops in BdpS and LS. Panel A shows the N-terminal loop of Ls in light gray and the N-terminal loop of BdpS in dark gray. Panel B shows that Loop I and Loop II are structurally homologous.

FIG. 34 shows the N-terminal loop of BdpS (dark gray) and P. tremuloides IspS (light gray) are structurally divergent. Panel A shows the N-terminal loop and panel B shows Loop I and Loop II.

FIG. 35 shows the N-terminal loop of LS (light gray) and P. tremuloides IspS (dark gray) are structurally divergent. Panel A shows the N-terminal loop and panel B shows Loop I and Loop II.

FIG. 36 shows the N-terminal loop of TEAS (light gray) and P. tremuloides IspS (dark gray) are structurally divergent. Panel A shows the N-terminal loop and panel B shows Loop I and Loop II. Loop I is disordered in TEAS.

FIG. 37 provides the amino acid sequence (SEQ ID NO:42) of a kudzu isoprene synthase.

FIG. 38 provides the amino acid sequence of a Populus [alba×tremuloides] isoprene synthase (SEQ ID NO:43).

FIG. 39 provides a map of plasmid pCL201 (pET24a P. alba IspS (MEA hairpin disrupt)).

FIG. 40 (40A, B, C) provides the nucleotide sequence (SEQ ID NO:44) of pCL201. The IspS CDS is underlined.

FIG. 41 provides the amino acid sequence of P. alba IspS residues 1 through 544 (SEQ ID NO:45).

FIG. 42 provides the three-dimensional structure of P. alba IspS shown as a dimer. Chain A is in dark gray and chain B is in light gray.

FIG. 43 provides a monomer view of the structure of P. alba IspS.

FIG. 44 provides a view of the structure of 25 sites chosen for SEL in stick diagram on the ribbon diagram backbone of the P. alba IspS monomer.

FIG. 45 shows the layout of a typical 96-well plate containing four complete libraries to be screened for isoprene production and protein concentration.

FIG. 46 provides the location of surface hydrophobic residue sites 469 and 494 of P. alba IspS.

FIG. 47 provides the location of flexible loop residue sites 443, 453 and 515 of P. alba IspS.

FIG. 48 provides the location of negatively charged residue site 323 of P. alba IspS dimer.

FIG. 49 provides the location of hinge residue site 229 of the P. alba IspS.

FIG. 50 provides the location of site 536 of P. alba IspS.

FIG. 51 shows an SDS-PAGE gel showing IspS-L494P at different stages of the purification. Lane 1—molecular weight standard; Lane 2—IspS-L494P prior to treatment with TurboTEV; Lane 3—IspS-L494P treated with TurboTEV; Lanes 4-6—IspS-L494P after final buffer exchange at different dilution levels.

FIG. 52 shows 2F_(O)-2F_(c) electron density map at residue 494 contoured at 1-sigma. Panel A shows 494L, Panel B shows 494P.

FIG. 53 depicts the alignment of the loop containing residue 494. Wild type IspS is light grey and IspS-L494P is dark grey. The L494P mutation results in an alternate loop structure.

FIG. 54 depicts a SDS-PAGE gel showing purified IspS-T536F at different dilutions (lanes 2-4) and molecular weight standard (lane 1).

FIG. 55 depicts a SDS-PAGE gel showing total cell lysate (lanes 2, 5, 8), supernatant (lanes 3, 6, 9), and purified protein (lanes 4, 7, 10) for wild type IspS, IspS-L494P and IspS-T536F, respectively. A molecular weight marker is in lane 1.

FIG. 56 depicts thermal unfolding curves for wild type IspS, IspS-L494P, and IspS-T536F incubated with buffer only. T_(M) values are indicated for each variant.

FIG. 57 depicts thermal unfolding curves for wild type IspS, IspS-L494P, and IspS-T536F incubated with 5 mM sodium pyrophosphate. T_(M) values are indicated for each variant.

FIG. 58 depicts temperature activity ration curves for wild type IspS (WT), IspS-L494P (LP), and IspS-T536F (TF). Data are plotted as a ratio of the specific activity (nmol/mg/min) of the protein at a given temperature divided by the specific activity at 35° C.

FIG. 59 depicts local alignment of P. alba isoprene synthase and related terpene synthase enzymes (SEQ IDS NOs: 99-112).

FIG. 60 depicts a map of plasmid MD09-163 with A453N, G491S, L494P, and T536C/F mutations.

FIG. 61 depicts a gel showing a dilution series of Isoprene Synthases assayed for rate vs. [DMAPP].

FIG. 62 depicts a graph showing the specific activity of each variant with 4 mM DMAPP assayed at 30° C. The black bar indicates the specific activity of the WT isoprene synthase.

FIG. 63 depicts a graph showing rate vs. [DMAPP] for the P, SP and SPC variants of isoprene synthase and WT isoprene synthase. Each data point on the graph is the average of three independently performed kinetic assays. Error bars are reported as one standard deviation above and below the data point.

FIG. 64 depicts an alignment of the P. tremuloides (black) and P. alba structures (grey) showing high level of structural homology.

DETAILED DESCRIPTION OF THE INVENTION

The present invention provides methods and compositions comprising at least one synthase enzyme with improved activity (e.g., catalytic activity) and/or solubility, variants of synthase and agents characterized by modifications of the amino acid residues in two flexible loops and/or N-terminus and/or their adjacent regions. In particular, the present invention provides for the selective modification of these segments in a three-dimensional structure of an isoprene synthase. Isoprene synthase contemplated by the invention include, but are not limited to plant isoprene synthases; e.g., poplar isoprene synthase, kudzu isoprene synthase, oak isoprene synthase and the like. Poplar isoprene synthase include, but are not limited to, isoprene synthases from P. tremuloides, P. alba, P. alba v. tremuloides, P. trichocharpa, and the like. Variant isoprene synthases for increased isoprene production in microbial host cells are derived based on the three-dimensional structure. Agents which can increase isoprene production can also be modeled using the three-dimensional structure of an isoprene synthase provided herein. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.

Unless otherwise indicated, the practice of the present invention involves conventional techniques commonly used in molecular biology, microbiology, and recombinant DNA, which are within the skill of the art. Such techniques are known to those of skill in the art and are described in numerous texts and reference works (See e.g., Sambrook et al., “Molecular Cloning: A Laboratory Manual,” Third Edition, Cold Spring Harbor, 2001; and Ausubel et al., “Current Protocols in Molecular Biology,” 1987). All patents, patent applications, articles and publications mentioned herein, both supra and infra, are hereby expressly incorporated herein by reference.

DEFINITIONS

As used herein, the term isoprene refers to 2-methyl-1,3-butadiene (CAS#78-79-5). Isoprene can be produced as the direct and final volatile C5 hydrocarbon product from the elimination of pyrophosphate from 3,3-dimethylallyl pyrophosphate (DMAPP), and does not involve the linking or polymerization of (an) IPP molecule(s) to (a) DMAPP molecule(s).

As used herein, the terms “isoprene synthase,” and “IspS,” refer to the enzymes that catalyze the elimination or pyrophosphate from diemethylallyl diphosphate (DMAPP) to form isoprene. In some preferred embodiments, the IspS is an enzyme obtained from plants such as kudzu, poplar or red oak. In some embodiments, the term “IspS” refers to a naturally occurring mature enzyme or portion thereof.

As used herein, the term “variant proteins” refers to proteins that differ from a parent protein (e.g., kudzu IspS set forth as SEQ ID NO:42 and P. alba IspS set forth in SEQ ID NO:16 or FIG. 23) and from one another by a small number of amino acid residues. The number of differing amino acid residues may be one or more, preferably 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 20, 30, 40, 50, or more amino acid residues. In some preferred embodiments, the number of different amino acids between variants is between 1 and 10. In some particularly preferred embodiments, related proteins and particularly variant proteins have at least 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, or 99% amino acid sequence identity. Related (and derivative) proteins can comprise “variant proteins.” Additionally, a related protein or a variant protein as used herein refers to a protein that differs from another related protein or a parent protein in the number of prominent regions. For example, in some embodiments, variant proteins have 1, 2, 3, 4, 5, or 10 corresponding prominent regions that differ from the parent protein.

As discussed in greater detail herein, several methods are known in the art that are suitable for generating variants of the enzymes of the present invention, including but not limited to site-saturation mutagenesis, scanning mutagenesis, insertional mutagenesis, random mutagenesis, site-directed mutagenesis, and directed-evolution, as well as various other recombinatorial approaches.

As used herein, the singular form “a”, “an”, and “the” includes plural references unless indicated otherwise.

As used herein, the term “agent” can refer to any type of composition of matter, including but not limited to, polypeptides, nucleotides, small molecules, and synthetic compounds.

As used herein, the term “gene” refers to a polynucleotide (e.g., a DNA segment) that encodes a polypeptide and includes regions preceding and following the coding regions as well as intervening sequences (introns) between individual coding segments (exons).

As used herein, the terms “starting gene” and “parent gene” refer to a gene of interest that encodes a protein of interest that is to be improved and/or changed using the present invention. Likewise, the terms “starting protein” and “parent protein” refer to a protein of interest that is to be improved and/or changed using the present invention.

As used herein, “homologous genes” refers to a pair of genes from different, but usually related species, which correspond to each other and which are identical or very similar to each other. The term encompasses genes that are separated by speciation (i.e., the development of new species) (e.g., orthologous genes), as well as genes that have been separated by genetic duplication (e.g., paralogous genes).

As used herein, “ortholog” and “orthologous genes” refer to genes in different species that have evolved from a common ancestral gene (i.e., a homologous gene) by speciation. Typically, orthologs retain the same function during the course of evolution. Identification of orthologs finds use in the reliable prediction of gene function in newly sequenced genomes.

As used herein, “paralog” and “paralogous genes” refer to genes that are related by duplication within a genome. While orthologs retain the same function through the course of evolution, paralogs evolve new functions, even though some functions are often related to the original one.

As used herein, “homology” refers to sequence similarity or identity, with identity being preferred. This homology is determined using standard techniques known in the art (See e.g., Smith and Waterman, Adv Appl Math, 2:482, 1981; Needleman and Wunsch, J Mol Biol, 48:443, 1970; Pearson and Lipman, Proc Natl Acad Sci USA, 85:2444, 1988; programs such as GAP, BESTFIT, FASTA, and TFASTA in the Wisconsin Genetics Software Package, Genetics Computer Group, Madison, Wis.; and Devereux et al., Nucl Acid Res, 12:387-395, 1984).

As used herein, an “analogous sequence” on an isoprene synthase is one wherein the function of the gene is essentially the same as the gene based on the kudzu isoprene synthase. Additionally, analogous genes include at least 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99% or 100% sequence identity with the sequence of the kudzu isoprene synthase. In additional embodiments more than one of the above properties applies to the sequence. Analogous sequences are determined by known methods of sequence alignment. A commonly used alignment method is BLAST, although as indicated above and below, there are other methods that also find use in aligning sequences.

“Percent sequence identity,” “percent amino acid sequence identity,” “percent gene sequence identity,” and/or “percent nucleic acid/polynucleotide sequence identity,” with respect to two amino acids, polynucleotide and/or gene sequences (as appropriate), refer to the percentage of residues that are identical in the two sequences when the sequences are optimally aligned. Thus, 80% amino acid sequence identity means that 80% of the amino acids in two optimally aligned polypeptide sequences are identical.

The phrase “substantially identical” in the context of two nucleic acids or polypeptides thus refers to a polynucleotide or polypeptide that comprising at least 70% sequence identity, preferably at least 75%, preferably at least 80%, preferably at least 85%, preferably at least 90%, preferably at least 95%, preferably at least 97%, preferably at least 98% and preferably at least 99% sequence identity as compared to a reference sequence using the programs or algorithms (e.g., BLAST, ALIGN, CLUSTAL) using standard parameters. One indication that two polypeptides are substantially identical is that the first polypeptide is immunologically cross-reactive with the second polypeptide. Typically, polypeptides that differ by conservative amino acid substitutions are immunologically cross-reactive. Thus, a polypeptide is substantially identical to a second polypeptide, for example, where the two peptides differ only by a conservative substitution. Another indication that two nucleic acid sequences are substantially identical is that the two molecules hybridize to each other under stringent conditions (e.g., within a range of medium to high stringency).

As used herein, the term “crystal lattice” means the array of points defined by the vertices of packed unit cells.

As used herein, the term “unit cell” means a basic parallelipiped shaped block. The entire volume of a crystal can be constructed by regular assembly of such blocks. Each unit cell comprises a complete representation of the unit of pattern, the repetition of which builds up the crystal. Thus, the term “unit cell” means the fundamental portion of a crystal structure that is repeated infinitely by translation in three dimensions. A unit cell is characterized by three vectors a, b, and c, not located in one plane, which form the edges of a parallelepiped. Angles α, β, and γ define the angles between the vectors: angle α is the angle between vectors b and c; angle β is the angle between vectors a and c; and angle γ is the angle between vectors a and b. The entire volume of a crystal can be constructed by regular assembly of unit cells; each unit cell comprises a complete representation of the unit of pattern, the repetition of which builds up the crystal.

The term “structure coordinates” refers to Cartesian coordinates derived from mathematical equations related to the patterns obtained on diffraction of a monochromatic beam of x-rays by the atoms (scattering centers) of an isoprene synthase complex in crystal form. The diffraction data are used to calculate an electron density map of the repeating unit of the crystal. The electron density maps are then used to establish the positions of the individual atoms of the isoprene synthase protein or protein/ligand complex.

As used herein, the terms “active site,” “binding site” or “binding pocket” refer to a region of a polypeptide or a molecular complex comprising the polypeptide that, as a result of the primary amino acid sequence of the polypeptide and/or its three-dimensional shape, favorably associates with another chemical entity or compound including ligands or inhibitors. Thus, an active site may include or consist of features such as interfaces between domains. Chemical entities or compounds that may associate with an active site include, but are not limited to, compounds, ligands, cofactors, substrates, inhibitors, agonists, antagonists, etc.

“Structural reaction residues” refers to a three-dimensional collection of atoms involved in an enzymatic reaction. For example, these would include those forming the active site, those coordinating metal ions and those forming the substrate bind region. In particular, those forming the flexible loops and N-terminus and the adjacent residues that stabilize the flexible segments when substrate is bound.

Structurally equivalent synthases refer to those synthases for which a crystallographic structure has been determined, whose atomic coordinates can be aligned by a publically available software package, such as PYMOL (DeLano Scientific LLC) such that a preponderance of the main chain alpha carbon atoms can be aligned within a rms deviation of 0.2 nm. For this purpose, a preponderance would be defined as either 50%, 60% or 70% of the total alpha carbons of the isoprene synthase structure.

The term “root mean square deviation” means the square root of the arithmetic mean of the squares of the deviations. It is a way to express the deviation or variation from a trend or object. For purposes of this invention, the “root mean square deviation” defines the variation in the backbone of a protein from the backbone of a P. tremuloides isoprene synthase, a P. alba isoprene synthase, or an active site portion thereof, as defined by the structure coordinates described herein.

“Having substantially the same three-dimensional structure” refers to a polypeptide that is characterized by a set of atomic structure coordinates that have a root mean square deviation (r.m.s.d.) of less than or equal to about 1.5 Å when superimposed onto the atomic structure coordinates of an isoprene synthase, e.g. the atomic structure coordinates of Table 3-7 or Table 4-2 when at least about 50% to 100% of the Cα atoms of the coordinates are included in the superposition.

As used herein, “homologous segment” refers to a segment of an enzyme having a root mean square deviation of less than about 1.5 Å in models of related enzymes. For example the model of the P. tremuloides isoprene synthase molecule or molecular complex listed in Table 3-7 can be used to identify homologous segments having a root mean square deviation of less than about 1.5 Å in models of related isoprene synthases.

Slight variations in structure coordinates can be generated by mathematically manipulating the isoprene synthase structure coordinates provided herein. For example, the structure coordinates set forth in Table 3-7 or Table 4-2 could be manipulated by crystallographic permutations of the structure coordinates, fractionalization of the structure coordinates, integer additions or subtractions to sets of the structure coordinates, inversion of the structure coordinates or any combination of the above. Alternatively, modifications in the crystal structure due to mutations, additions, substitutions, and/or deletions of amino acids, or other changes in any of the components that make up the crystal, could also yield variations in structure coordinates. Such slight variations in the individual coordinates will have little effect on overall shape. If such variations are within an acceptable standard error as compared to the original coordinates, the resulting three-dimensional shape is considered to be structurally equivalent. Thus, for the purpose of the structures provided herein, any active site, binding site or binding pocket defined by a set of structure coordinates for a polypeptide or for a homolog of a polypeptide from any source having a root mean square deviation of non-hydrogen atoms of less than about 1.5 Å when superimposed on the non-hydrogen atom positions of the corresponding atomic coordinates of Table 3-7 or Table 4-2, are considered substantially identical or homologous.

As used herein, “equivalent or homologous residues” refers to proteins that share particular amino acid residues. Equivalent residues may be identified by determining homology at the level of tertiary structure for a terpene synthase (e.g., isoprene synthase) whose tertiary structure has been determined by x-ray crystallography. Equivalent residues are defined as those for which the atomic coordinates of two (2) or more of the main chain atoms of a particular amino acid residue of the terpene synthase having putative equivalent residues and the substrate of interest (e.g., N on N, CA on CA, C on C and O on O) are within 0.2 nm and preferably 0.15 nm after alignment. Alignment is achieved after the best model has been oriented and positioned to give the maximum overlap of atomic coordinates of non-hydrogen protein atoms of the terpene synthases and substrates analyzed. The preferred model is the crystallographic model giving the lowest R factor for experimental diffraction data at the highest resolution available, determined using methods known to those skilled in the art of crystallography and protein characterization/analysis. For example, equivalent residues which are functionally analogous to a specific residue of isoprene synthase are defined as those amino acids at a structurally homologous synthase which may adopt a conformation such that they either alter, modify, or contribute to protein structure, substrate binding or catalysis in a manner defined or attributed to a specific residue of isoprene synthase.

Isoprene Synthase

Isoprene monomer is employed in the manufacture of polyisoprene and various copolymers (with isobutylene, butadiene, styrene, or other monomers). To build a strain (prokaryotic or eukaryotic) capable of producing commercially viable levels of isoprene requires optimization of the entire pathway, either MVA to isoprene or DXP to isoprene. A key enzyme in the pathway is isoprene synthase (IspS), which converts the precursor DMAPP to isoprene. The only isoprene synthases (IspS) identified to date are those from plants such as poplar, English oak and kudzu vine. Although some bacteria, such as Bacillus subtilis, also produce isoprene, a prokaryotic IspS has yet to be identified and the native IspS activity in Bacillus is not sufficient for a commercial process. The plant IspS enzymes identified to date have been partially characterized in part by expression in E. coli and some of the kinetic parameters of these enzymes have been determined in vitro with purified protein. However, the kinetic parameters (K_(m), rate, etc.) of the native IspS enzymes are insufficient for commercial production of isoprene in a biological host.

To solve this problem as described herein, an isoprene synthase is expressed in a bacterial host. In addition, the isoprene synthase is engineered for a change in a property of interest. The invention provides a three-dimensional structure which can aid in the design of variants of isoprene synthase and agents with similar three-dimensional structure and/or reaction coordinates to the three-dimensional structure provided herein. These variants and agents are useful for the commercial production of isoprene in a biological host.

Characterization of wild-type and mutant isoprene synthase is accomplished via any means or “test” suitable and is preferably based on the assessment of properties of interest. Properties of interest include but are not limited to: pH optima, temperature stability (e.g., T_(m) value), intracellular and extracellular solubility, K_(m) value, k_(cat) value, or specific activity, as well as sensitivity to potential inhibitors including substrate or product inhibition. Oxidative and proteolytic stability are also of interest. Furthermore, activation or inhibition due to metal ion effects and ionic strength is of interest. These properties and parameters can be assessed by the conversion of DMAPP to isoprene in vitro with purified or partially purified isoprene synthase or in vivo in the context of a host organism such as E. coli expressing the DXP pathway, the MVA pathway, or both. It is contemplated that enzymes having various degrees of stability, solubility, activity, and/or expression level in one or more of test conditions will find use in the present invention for the production of isoprene in a diversity of hosts.

The invention features compositions and methods for the production of increased amounts of isoprene. In particular, these compositions and methods increase the rate of isoprene production and increase the total amount of isoprene that is produced. The biosynthetic processes for isoprene production described herein are a desirable alternative to using natural rubber. As discussed further below, the amount of isoprene produced by cells can be greatly increased by introducing a heterologous nucleic acid encoding an isoprene synthase (IspS) polypeptide into the cells. Isoprene synthase polypeptides convert dimethylallyl diphosphate (DMAPP) into isoprene.

Additionally isoprene production by cells containing a heterologous isoprene synthase nucleic acid can be enhanced by increasing the amount of a 1-deoxy-D-xylulose-5-phosphate synthase (DXS) polypeptide, and/or an isopentenyl diphosphate isomerase (IDI) polypeptide, expressed by the cells. For example, a DXS nucleic acid and/or an IDI nucleic acid can be introduced into the cells. The DXS nucleic acid may be a heterologous nucleic acid or a duplicate copy of an endogenous nucleic acid. Similarly, the IDI nucleic acid may be a heterologous nucleic acid or a duplicate copy of an endogenous nucleic acid. In some embodiments, the amount of DXS and/or IDI polypeptide is increased by replacing the endogenous DXS and/or IDI promoters or regulatory regions with other promoters and/or regulatory regions that result in greater transcription of the DXS and/or IDI nucleic acids. In some embodiments, the cells contain both a heterologous nucleic acid encoding an isoprene synthase polypeptide (e.g., a plant isoprene synthase nucleic acid) and a duplicate copy of an endogenous nucleic acid encoding an isoprene synthase polypeptide.

The encoded DXS and IDI polypeptides are part of the DXP pathway for the biosynthesis of isoprene (FIG. 1). DXS polypeptides convert pyruvate and D-glyceraldehyde-3-phosphate into 1-deoxy-D-xylulose-5-phosphate. While not intending to be bound by any particular theory, it is believed that increasing the amount of DXS polypeptide increases the flow of carbon through the DXP pathway, leading to greater isoprene production. IDI polypeptides catalyze the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). While not intending to be bound by any particular theory, it is believed that increasing the amount of IDI polypeptide in cells increases the amount of IPP that is converted into DMAPP, which in turn is converted into isoprene.

In some embodiments, the production of isoprene by cells containing a heterologous isoprene synthase nucleic acid can be augmented by increasing expression of one or more MVA polypeptide(s) in the cells (FIG. 1). Exemplary MVA pathways polypeptides include any of the following polypeptides: acetyl-CoA acetyltransferase (AA-CoA thiolase) polypeptides, 3-hydroxy-3-methylglutaryl-CoA synthase (HMG-CoA synthase) polypeptides, 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase) polypeptides, mevalonate kinase (MVK) polypeptides, phosphomevalonate kinase (PMK) polypeptides, diphosphomevalonte decarboxylase (MVD) polypeptides, IDI polypeptides, and polypeptides (e.g., fusion polypeptides) having an activity of two or more MVA pathway polypeptides. For example, one or more MVA pathway nucleic acids can be introduced into the cells. In some embodiments, the cells contain the upper MVA pathway, which includes AA-CoA thiolase, HMG-CoA synthase, and HMG-CoA reductase nucleic acids. In some embodiments, the cells contain the lower MVA pathway, which includes MVK, PMK, MVD, and IDI nucleic acids. In some embodiments, the cells contain the entire MVA pathway, which includes AA-CoA thiolase, HMG-CoA synthase, HMG-CoA reductase, MVK, PMK, MVD, and IDI nucleic acids. The MVA pathway nucleic acids may be heterologous nucleic acids or duplicate copies of endogenous nucleic acids. In some embodiments, the amount of one or more MVA pathway polypeptides is increased by replacing the endogenous promoters or regulatory regions for the MVA pathway nucleic acids with other promoters and/or regulatory regions that result in greater transcription of the MVA pathway nucleic acids. In some embodiments, the cells contain both a heterologous nucleic acid encoding an isoprene synthase polypeptide (e.g., a plant isoprene synthase nucleic acid) and a duplicate copy of an endogenous nucleic acid encoding an isoprene synthase polypeptide.

In some embodiments, at least a portion of the cells maintain the heterologous isoprene synthase, DXS, IDI, and/or MVA pathway nucleic acid for at least about 5, 10, 20, 50, 75, 100, 200, 300, or more cell divisions in a continuous culture (such as a continuous culture without dilution). In some embodiments of any of the aspects of the invention, the nucleic acid comprising the heterologous or duplicate copy of an endogenous isoprene synthase, DXS, IDI, and/or MVA pathway nucleic acid also comprises a selective marker, such as a kanamycin, ampicillin, carbenicillin, gentamicin, hygromycin, phleomycin, bleomycin, neomycin, or chloramphenicol antibiotic resistance nucleic acid.

Isoprene synthase polypeptides convert dimethylallyl diphosphate (DMAPP) into isoprene. Exemplary isoprene synthase polypeptides include polypeptides, fragments of polypeptides, peptides, and fusions polypeptides that have at least one activity of an isoprene synthase polypeptide. Standard methods can be used to determine whether a polypeptide has isoprene synthase polypeptide activity by measuring the ability of the polypeptide to convert DMAPP into isoprene in vitro, in a cell extract, or in vivo. Isoprene synthase polypeptide activity in the cell extract can be measured, for example, as described in Silver et al., J. Biol. Chem. 270:13010-13016, 1995 and references therein, which are each hereby incorporated by reference in their entireties, particularly with respect to assays for isoprene synthase polypeptide activity.

In one embodiment, DMAPP (Sigma) is evaporated to dryness under a stream of nitrogen and rehydrated to a concentration of 100 mM in 100 mM potassium phosphate buffer pH 8.2 and stored at −20° C. To perform the assay, a solution of 5 μl of 1M MgCl₂, 1 mM (250 μg/ml) DMAPP, 65 μl of Plant Extract Buffer (PEB) (50 mM Tris-HCl, pH 8.0, 20 mM MgCl₂, 5% glycerol, and 2 mM DTT) is added to 25 μl of cell extract in a 20 ml Headspace vial with a metal screw cap and teflon coated silicon septum (Agilent Technologies) and cultured at 37° C. for 15 minutes with shaking. The reaction is quenched by adding 200 μl of 250 mM EDTA or by heat inactivation, and isoprene is quantified by GC/MS.

Exemplary isoprene synthase nucleic acids include nucleic acids that encode a polypeptide, fragment of a polypeptide, peptide, or fusion polypeptide that has at least one activity of an isoprene synthase polypeptide. Exemplary isoprene synthase polypeptides and nucleic acids include naturally-occurring polypeptides and nucleic acids from any of the source organisms described herein as well as variant polypeptides and nucleic acids derived from any of the source organisms described herein.

In some embodiments, the isoprene synthase polypeptide or nucleic acid is from the family Fabaceae, the family Salicaceae, or the family Fagaceae. In some embodiments, the isoprene synthase polypeptide or nucleic acid is a naturally-occurring polypeptide or nucleic acid from Pueraria montana (kudzu) (Sharkey et al., Plant Physiology 137: 700-712, 2005), poplar (such as Populus alba×tremula CAC35696, Miller et al., Planta 213: 483-487, 2001) or Populus alba, aspen (such as Populus tremuloides) Silver et al., JBC 270(22): 13010-1316, 1995), or English Oak (Quercus robur) (Zimmer et al., WO 98/02550), which are each hereby incorporated by reference in their entireties, particularly with respect to isoprene synthase nucleic acids and the expression of isoprene synthase polypeptides. Suitable isoprene synthases include, but are not limited to, those identified by GenBank Accession Nos. AY341431, AY316691, AB198180, AJ294819.1, EU693027.1, EF638224.1, AM410988.1, EF147555.1, AY279379, AJ457070, and AY182241, which are each hereby incorporated by reference in their entireties, particularly with respect to sequences of isoprene synthase nucleic acids and polypeptides. In some embodiments, the isoprene synthase polypeptide or nucleic acid is not a naturally-occurring polypeptide or nucleic acid from Quercus robur (i.e., the isoprene synthase polypeptide or nucleic acid is an isoprene synthase polypeptide or nucleic acid other than a naturally-occurring polypeptide or nucleic acid from Quercus robur). In some embodiments, the isoprene synthase nucleic acid or polypeptide is not a naturally-occurring polypeptide or nucleic acid from poplar (such as Populus alba×tremula CAC35696).

Three Dimensional Structure and/or Crystallization

Polypeptides, e.g. isoprene synthase, have a three-dimensional structure determined by the primary amino acid sequence and the environment surrounding the polypeptide. This three-dimensional structure establishes the polypeptide's activity, stability, binding affinity, binding specificity, and other biochemical attributes. Thus, knowledge of a protein's three-dimensional structure can provide much guidance in designing improvements to its biological activity; for example, greater catalytic activity and/or solubility.

The three-dimensional structure of a polypeptide can be determined in a number of ways. Many of the most precise methods employ X-ray crystallography (See, e.g., Van Holde, (1971) Physical Biochemistry, Prentice-Hall, New Jersey, pp. 221-39). This technique relies on the ability of crystalline lattices to diffract X-rays or other forms of radiation. Diffraction experiments suitable for determining the three-dimensional structure of macromolecules typically require high-quality crystals. The crystallization properties of a polypeptide vary greatly (Dale, et al., J. Struct. Biol. 142:88-97, 2003; MacPherson, A., Methods 34:254-265, 2004; and Slabinski, L et al., Protein Science 16:2472-2482, 2007). In some cases, polypeptides crystallize readily whereas in other cases, polypeptides have proven extremely difficult to obtain. There is no comprehensive theory to guide efforts to crystallize macromolecules and as a result, most efforts macromolecular crystal growth is empirical in nature (MacPherson, 2004). Factors which can influence the production of crystals including physical, chemical and biochemical factors. These factors include purity of the polypeptide, pH, salt, and concentrations of other precipitants.

Another key variable in the generation of crystals of a polypeptide is the polypeptide itself. Some polypeptides crystallize rather easily while homologous proteins prove to be very difficult to crystallize (Dale et al. 2003). It is generally recognized that rigid, stable proteins are much more likely to crystallize than proteins that are internally flexible or have dynamic surfaces. Solubility is another factor that impacts macromolecular crystallization. Insoluble polypeptides do not readily form crystals because they tend to aggregate. Highly soluble polypeptides, on the other hand, do not readily form crystals because of difficulties in obtaining a supersaturated state. Glycoslyated polypeptides also do not readily form crystals because they tend to be highly soluble. As such, posttranslational modifications can have a large impact on the crystallization of a polypeptide.

Another hurdle in the development of a three-dimensional structure of a polypeptide is the “phase problem.” A crystal behaves like a three-dimensional diffraction grating, which gives rise to both constructive and destructive interference effects in the diffraction pattern, such that it appears on the detector as a series of discrete spots which are known as reflections. Each reflection contains information on all atoms in the structure and conversely each atom contributes to the intensity of each reflection. As with all forms of electro-magnetic radiation, X-rays have wave properties, in other words, they have both an amplitude and a phase. In order to recombine a diffraction pattern, both of these parameters are required for each reflection. Unfortunately, only the amplitudes can be recorded experimentally and as such, all phase information is lost. One method to solve the “phase problem” is to compare the molecular coordinates with the coordinates of a similar protein by a process called Molecular Replacement.

“Molecular Replacement” refers to the method of calculating initial phases for a new crystal of a polypeptide whose structure coordinates are unknown by orienting and positioning a polypeptide whose structure coordinates are known within the unit cell of the new crystal so as to best account for the observed diffraction pattern of the new crystal. Phases are then calculated from the oriented and positioned polypeptide and combined with observed amplitudes to provide an approximate Fourier synthesis of the structure of the polypeptides comprising the new crystal (Jones et al., 1991, Acta Crystallogr. 47:753-70; Brunger et al., 1998, Acta Crystallogr. D. Biol. Crystallogr. 54:905-21).

The isoprene synthases of plants are expected to be homologous to terpene synthases. Previous efforts to utilize the structure of isoprene synthase in order to improve production of isoprene have relied on the structures of other terpene synthases in which three-dimensional structures are available including bornyl diphosphate synthase and 5-epi-aristolochene synthase (see e.g., U.S. Provisional patent application Ser. No. 12/429,143 and WO 2008/137092).

A set of coordinates determined by X-ray crystallography is not without standard error. In general, the error in the coordinates tends to be reduced as the resolution is increased, since more experimental diffraction data is available for the model fitting and refinement. Thus, for example, more diffraction data can be collected from a crystal that diffracts to a resolution of 3.0 angstroms than from a crystal that diffracts to a lower resolution, such as 3.5 angstroms. Consequently, the refined structural coordinates will usually be more accurate when fitted and refined using data from a crystal that diffracts to higher resolution. If the coordinates are not sufficiently accurate, then the design process will be ineffective. In most cases, it is very difficult or impossible to collect sufficient diffraction data to define atomic coordinates precisely when the crystals diffract to a resolution of only 3.5 angstroms or poorer. Thus, in most cases, it is difficult to use X-ray structures in structure-based ligand design when the X-ray structures are based on crystals that diffract to a resolution of only 3.5 angstroms or poorer. However, common experience has shown that crystals diffracting to 3.0 angstroms or better can yield X-ray structures with sufficient accuracy to greatly facilitate structure-based drug design. Further improvement in the resolution can further facilitate structure-based design, but the coordinates obtained at 3.0 angstroms resolution are generally adequate for most purposes. The three-dimensional structure of isoprene synthase provided by the present invention was resolved to 3.05 angstroms (see Example 3).

Three Dimensional Structure and/or Crystallization of IspS

A number of different constructs expressing different isoprene synthases were generated in order to obtain a three-dimensional structure of the enzyme. One construct contained the kudzu isoprene synthase linked to a fragment of the maltose binding protein (MBP) to facilitate purification. The purified MBD-Kudzu isoprene synthase was subjected to commercially available crystallization screens including Crystal Screen (Hampton Research) and JCSG+ Suite (Qiagen). No fewer than 1536 different conditions were surveyed, including ranges of pH, protein concentration and crystallization reagents. In the majority of cases, the MBP-Kudzu isoprene synthase fusion protein precipitated out of solution and no crystals were obtained.

A second attempt to crystallize isoprene synthase focused on isoprene synthase from P. alba. Here the protein was linked to a histidine tag for ease of purification. Over 288 conditions were screened and the nine best crystals were prepared for data collection but the crystals either did not defract or were salt crystals. Likewise, crystals derived from a full-length, untagged P. alba isoprene synthase and an N-terminally truncated P. trichocharpa isoprene synthase did not diffract.

Crystals were obtained from a construct containing a 19 residue N-terminal truncation of P. alba isoprene synthase and linked to a histidine tag. Resolution of the crystal structure was improved from 16 Å to 5 Å. As discussed above, it is preferred that three-dimensional structures are determined in cases where crystal resolution is 3.5 Å or finer. Crystals were obtained from a second N-terminally truncated P. alba isoprene synthase following a screen of 528 variations of pH, precipitating agents, concentrations and inhibitors. In order to improve diffraction, various crystal freezing conditions were tested but the diffraction limits only improved from 10 Å to 6.5 Å. Crystallization conditions were further optimized and a crystal resolution of 2.7 Å was obtained.

An isoprene synthase from P. tremuloides was generated with an N-terminal truncation and a histidine tag and used in commercially available screens. Rod and plate-like crystals were observed and an additional 120 experiments were performed by varying pH, concentration and crystallization reagents. Here, the best crystal has a resolution of 5 Å. Modification of the freezing conditions resulted in a crystal that diffracted at 3.3 Å and ultimately to 3.05 Å using beamline 11-1 of the Stanford Synchroton Radiation Laboratory.

The phasing problem was resolved by molecular replacement using a monomer of limonene synthase as the starting model. Like isoprene synthase, limonene synthase is terpene synthase which has 41.4% sequence identity to P. tremuloides isoprene synthase.

The invention provides a crystalline form of isoprene synthase. In some aspects, the invention provides a crystalline from of P. tremuloides isoprene synthase. The crystals belong to the tetragonal space group P4₃2₁2, and have unit cell dimensions a is about 154.2 Å, b is about 154.2 Å, c is about 142.7 Å where α=β=γ=90°. Unit cells dimensions may vary; for example, by 5%. In some aspects, the invention provides a crystalline from of P. alba isoprene synthase. The crystals belong to the tetragonal space group P4₃2₁2, and have unit cell dimensions a is about 156.8 Å, b is about 156.8 Å, c is about 142.5 Å where α=β=γ=90°.

The structure is found to be structurally homologous to other known synthase structures specifically bornyl diphosphate synthase, 5-epi-aritolochene synthase and 4S-limonene synthase. All share a common overall tertiary fold, as measured by a lower than 2.0 Angstrom (0.2 nm) standard deviation for a preponderance of the main chain alpha carbon atoms following alignment. Isoprene synthase has 541 amino acid residues, each with one alpha carbon atom: 433 of these can be aligned with those of limonene synthase with a root mean squared deviation (rms) of 0.12 nm; 418 of these can be aligned with those of bornyl diphosphate synthase with an rms of 0.12 nm; and 395 of these can be aligned with those of 5-epi-aristolochene synthase with an rms of 0.14 nm.

The invention provides the three-dimensional structure of the active site of isoprene synthase. The metal ion and phosphate recognition region comprises amino acid residues Arg 255, Asp 292, Asp 296, Glu 370, Arg 433 and Asn436 of the P. tremuloides isoprene synthase. As such, the invention provides the site where dimethylallyl pyrophosphate may bind and react with the isoprene synthase to produce isoprene. Side chains of amino acid residues in the P. tremuloides IspS that are found in proximity to the metal and diphosphate binding side chains include Asp 293, Tyr 385, Ser 392, and Asp 437.

The invention provides the substrate access loops of isoprene synthase. The substrate access loops of P. tremuloides IspS are in regions that deviate from the bornyl diphosphate synthase (BdpS) structure. In the BdpS structure, the residues create a cover over the active site. Upon substrate binding, the structure of P. tremuloides IspS may form a similar structure. In the P. tremuloides IspS enzyme, residues 440-453, which have the sequence SASAEIARGETANS (SEQ ID NO:40), and residues 512-526, which have the sequence YHNGDAHTSPDEL (SEQ ID NO:41), form the substrate access loops.

The invention provides the three-dimensional structure of the isoprenyl binding site of isoprene synthase. These are residues in the P. tremuloides IspS structure that may bind to the product, isoprene. These residues include Ser 261, Trp 264, Phe 285, Thr 289, Ser 393, Ser 394, Phe 432, and Tyr 512.

In some aspects the invention provides the three-dimensional structure of isoprene synthase which further comprises a ligand; for example, dimethylallyl pyrophosphate. In some cases, the three-dimensional structure of isoprene synthase without a ligand is compared to the three-dimensional structure of isoprene synthase with bound ligand. Such comparisons in the three-dimensional structures of isoprene synthase with or without a ligand may reveal structural perturbations in the enzyme following substrate binding. Molecular modeling may provide clues for designing variants of isoprene synthase for improved activity.

The invention provides structurally equivalent agents that mimic the structure of isoprene synthase or a portion thereof. A structurally equivalent agent is related in terms of its three-dimensional structure. In some cases, the structurally equivalent agent mimics the activity (e.g. catalytic activity) of the isoprene synthase or a structurally equivalent portion of the isoprene synthase. For example, a structurally equivalent agent may be structurally analogous to the active site of an isoprene synthase.

Use of Three-Dimensional Structure of Isoprene Synthase

Structure information, typically in the form of the atomic structure coordinates, can be used in a variety of computational or computer-based methods to, for example, design, screen for and/or identify variants of isoprene synthase for improved activity, expression or stability. Three-dimensional modeling may be performed using the experimentally determined coordinates derived from X-ray diffraction patterns, such as those in Table 3-7 and Table 4-2, for example, wherein such modeling includes, but is not limited to, drawing pictures of the actual structures, building physical models of the actual structures, and determining the structures of related subunits and /ligand and subunit/ligand complexes using the coordinates. Such molecular modeling can utilize known X-ray diffraction molecular modeling algorithms or molecular modeling software to generate atomic coordinates corresponding to the three-dimensional structure of an isoprene synthase.

The structure coordinates generated for P. tremuloides isoprene synthase or one of its active sites shown in Table 3-7, P. alba isoprene synthase or one of its active sites shown in Table 4-2 or the structure coordinates generated by P. tremuloides or P. alba isoprene synthase/ligand complex define a unique configuration of points in space. Those of skill in the art understand that a set of structure coordinates for protein or an protein/ligand complex, or a portion thereof, define a relative set of points that, in turn, define a configuration in three dimensions. A similar or identical configuration can be defined by an entirely different set of coordinates, provided the distances and angles between coordinates remain essentially the same. In addition, a scalable configuration of points can be defined by increasing or decreasing the distances between coordinates by a scalar factor while keeping the angles essentially the same.

The invention provides methods for increasing the production of isoprene in a host cell by increasing the activity, expression or stability of an isoprene synthase in the host cell. Based on the three-dimensional structure of isoprene synthase, one of skill in the art can use computational methods to modify properties of the isoprene synthase including but not limited to pH optima, K_(M) value, k_(cat) value, and specific activity of the enzyme. In other aspects of the invention, the three-dimensional structure of isoprene synthase or agents with similar three-dimensional structures may be used as a guide to improve oxidative and/or proteolytic stability of isoprene synthase. The three-dimensional structure of isoprene synthase may be used to evaluate inhibitors of its enzymatic activity including, but not limited to, substrate and product inhibition. In other aspects of the invention, the three dimensional structure may be used to design isoprene synthase variants agents with similar three-dimensional structures for increased expression; for example, by making amino acid substitutions in the isoprene synthase protein which do not alter the three dimensional structure of the protein but allow more favorable expression for a given host cell.

In some aspects of the invention, a portion of the three dimensional structure of isoprene synthase may be used as a guide to design isoprene synthase variants or to design agents that mimic at least a portion of the isoprene synthase. As such, the invention provides a three dimensional configuration of points of a portion of the points shown in Table 3-7 or Table 4-2 or Table 8-2. Examples of portions of isoprene synthase include, but are not limited to, an active site, a diphosphate/metal binding site, an isoprenyl binding site, a flexible loop, a hinge region, and an electrostatic patch region.

In some aspects, the invention provides a three dimensional configuration of points that are analogous to the three dimensional configuration of points shown in Table 3-7 or Table 4-2 or Table 8-2 or a portion thereof. Analogous three dimensional configuration of points are at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, or 100% identical to the three dimensional configuration of points shown in Table 3-7 or Table 4-2 or a portion thereof, such as an active site, a diphosphate/metal binding site, an isoprenyl binding site, a flexible loop, a hinge region or an electrostatic patch region.

The three-dimensional structures of P. tremuloides IspS provide the identification of sites in the P. tremuloides IspS and other poplar isoprene synthases (e.g. P. alba IspS) that are candidates for mutagenesis to produce variant isoprene synthase enzymes with improved performance. The present invention provides sites isoprene synthase that might alter the interaction of the metal binding, diphosphate recognition, DMAPP chain binding, isoprenyl binding and/or the approach to the active site. Variants of isoprene synthase are designed for greater production of isoprene in host cells.

In some aspects, the invention provides methods of developing variants of isoprene synthase with improved enzyme kinetics. Improved enzyme kinetics can be determined by enzymatic assays. An increase in k_(cat) and/or a decrease in K_(i) or K_(M) compared to wild type isoprene synthase indicated an increase in the specific activity of the variant.

It is to be understood the disclosure herein for generating variants using three dimensional structure of isoprene synthase are equally applicable to other enzymes having substantially the same three-dimensional structure. This can refers to a polypeptide that is characterized by a set of atomic structure coordinates that have a root mean square deviation (r.m.s.d.) of less than or equal to about 1.5 Å when superimposed onto the atomic structure coordinates of an isoprene synthase, e.g. the atomic structure coordinates of Table 3-7 or Table 4-2 or Table 8-2 when at least about 50% to 100% of the Cα atoms of the coordinates are included in the superposition.

The invention also contemplates generating variants using homologous segments to the three dimensional structure of the isoprene synthases disclosed herein. This can refer to a segment of an enzyme having a root mean square deviation of less than about 1.5 Å in models of related enzymes. For example the model of the P. tremuloides isoprene synthase molecule or molecular complex listed in Table 3-7, Table 4-2 or Table 8-2 can be used to identify homologous segments having a root mean square deviation of less than about 1.5 Å in models of related isoprene synthases.

Slight variations in structure coordinates can be generated by mathematically manipulating the isoprene synthase structure coordinates provided herein. For example, the structure coordinates set forth in Table 3-7 or Table 4-2 or Table 8-2 could be manipulated by crystallographic permutations of the structure coordinates, fractionalization of the structure coordinates, integer additions or subtractions to sets of the structure coordinates, inversion of the structure coordinates or any combination of the above. Alternatively, modifications in the crystal structure due to mutations, additions, substitutions, and/or deletions of amino acids, or other changes in any of the components that make up the crystal, could also yield variations in structure coordinates. Such slight variations in the individual coordinates will have little effect on overall shape. If such variations are within an acceptable standard error as compared to the original coordinates, the resulting three-dimensional shape is considered to be structurally equivalent. Thus, for the purpose of the structures provided herein, any active site, binding site or binding pocket defined by a set of structure coordinates for a polypeptide or for a homolog of a polypeptide from any source having a root mean square deviation of non-hydrogen atoms of less than about 1.5 Å when superimposed on the non-hydrogen atom positions of the corresponding atomic coordinates of Table 3-7 or Table 4-2 or Table 8-2, are considered substantially identical or homologous. As such, all variants with equivalent or homologous residues are contemplated within the scope of this invention, regardless if it is has the same amino acid(s) or a different amino acid(s).

As described above, the present invention provides the three-dimensional structure of the active site (diphosphate/metal binding site) of isoprene synthase. The active site includes amino acid residues Arg 255, Asp 292, Asp 296, Glu 370, Arg 433 and Asn436 if P. tremuloides isoprene synthase. In addition, based on the three-dimensional structure of P. tremuloides isoprene synthase, the side chains of amino acid residues found in proximity to the diphosphate/metal binding site were identified. These residues include, but are not limited to, Asp 293, Tyr 385, Ser 392, and Asp 437 of P. tremuloides isoprene synthase. Engineering of these sites may result in increased enzyme activity. In some cases, mutation in an active site residue may decrease or completely abolish the activity of the isoprene synthase.

The three-dimensional structure of isoprene synthase may also be used to identify residues that bind the substrate of isoprene synthase, e.g. DMAPP. The residues may be used as a basis to generate isoprene synthase variants that may be used modulate substrate specificity and/or reaction rates (altered on and off rates of substrate and product). These residues include, but are not limited to, Ser 261, Trp 264, Phe 285, Thr 289, Ser 393, Ser 394, Phe 432, and Try 512 of P. tremuloides isoprene synthase.

The three dimensional structure of isoprene synthase has revealed that several loops forming the active site are flexible. One may exploit the flexibility to enhance enzyme performance by making substitutions in the amino aids forming these segments to facilitate the transitions the enzyme must undergo in the steps of binding substrate and allowing rearrangement of substrate in different kinetic steps that are postulated to occur during enzymatic de-phosphorylation and for electron transfer to convert DMAPP to isoprene. Three segments have been identified that form a considerable portion of the substrate binding pocket, notably the truncated N-terminus, along with two loops comprised of residues 438-453 (Loop I) and residues 512-527 (Loop II) (FIGS. 33-36). These loops may be present in at least two conformations: the “open” form in the absence of substrate and a “closed,” or active form when the substrate is bound. These residues provide targets for the generation of isoprene synthase variants with improved activity. For example, the residues in these loops of P. tremuloides isoprene synthase, including residues 440-453 (SASAEIARGETANS (SEQ ID NO:40)) and 512-524 (YHNGDAHTSPDEL (SEQ ID NO:41)), may be in a position to alter the activity of the isoprene synthase.

The flexible loop residues of isoprene synthase can be targets for Site Evaluation Library analysis. A library can be generated such that a particular amino acid residue(s) are mutated to different amino acid substitutions and then tested for activity (e.g. DMAPP activity) in an appropriate host cell. As exemplified in Example 5 below, residues A443, A453, N545, H515, A519 and E525 of the P. alba IspS (SEQ ID NO:41) were mutated and analyzed for DMAPP activity. P. alba IspS variants with improved activity identified by this analysis include, but are not limited to, A453N, H515M, A453I and A443S. Thus, other mutations in the flexible loop or mutations that affect the flexible loop can be found that increase isoprene synthase activity in the manner described herein. For example, conservative substitutions can be made that result in an increase in isoprene synthase activity.

The three-dimensional structure of isoprene synthase has revealed amino acids on the surface of the enzyme. For example, surface hydrophobic residues may affect protein folding, solubility or activity. In order to enhance the solubility of isoprene synthase, hydrophobic surface residues may be mutated to reduce the tendency of the enzyme to aggregate. In some cases, hydrophobic surface residues may be mutated to neutral of hydrophilic residues to increase the solubility and/or decrease the aggregation of isoprene synthase molecules. One skilled in the art would recognize hydrophobic residues, neutral residues and hydrophilic residues. Examples of surface hydrophobic residues include but are not limited to I28, V30, L130, G153, V299, L303, L469 and L494 of the P. alba IspS (SEQ ID NO:41). P. alba IspS variants with improved activity include, but are not limited to, L494P, L494C, L494V, L494G, L494I and L469A. Thus, other mutations in the surface hydrophobic residues can be found that increase isoprene synthase activity in the manner described herein. For example, conservative substitutions can be made that result in an increase in isoprene synthase activity. It is to be understood that all descriptions of mutations and/or substitutions herein refer to one mutation by itself or a combination (e.g., 2, 3, 4, 5, or more) of mutations. For example, an isoprene synthase variant with L494P is contemplated as well as an isoprene synthase variant with L494P and T536F.

The three dimensional structure of isoprene synthase has a “hinge region” located in a helix that spans the N-terminus and the C-terminus. In one aspect, the three dimensional structure of isoprene synthase has a “hinge region” located in a helix that spans the N-terminus and the C-terminus of the protein monomer. Without being bound by theory, the hinge region may dictate how these two halves of the enzyme may interact with each other. The hinge region includes residues 216-244. Examples of amino acid residues in the hinge region or that may interact with the hinge region include, but are not limited to, R198, I229 and L260 of the P. alba IspS (SEQ ID NO:41). Variants in the hinge region with improved activity include, but are not limited to, I229C, I229T, I229P, I229N, L260N, L260M, and L260I. Thus, other mutations in the hinge residues can be found that increase isoprene synthase activity in the manner described herein. For example, conservative substitutions can be made that result in an increase in isoprene synthase activity.

An electrostatic patch was identified by the three dimensional structure of isoprene synthase by the presence of a high density of acidic residues. Residues in the electrostatic patch include D304, E307, D311, E314 and D323. Without being bound by theory, this region may regulate activity of isoprene synthase. Examples of amino acid residues in the electrostatic patch include but are not limited to D311 and D323 of the P. alba IspS (SEQ ID NO:41). Variants with improved activity include, but are not limited to, D311M, D311F, D311L, D311G, D311I, D311A, D311T, D311R, D311V, D311E, D323W, D323Y, D323F, D323I, D323S, D323V, D323A, D323G, and D323Q. Thus, other mutations in the electrostatic patch residues or that affect the electrostatic patch can be found that increase isoprene synthase activity in the manner described herein. For example, conservative substitutions can be made that result in an increase in isoprene synthase activity.

Analysis of the three dimensional structure of isoprene synthase revealed other regions for targeting variants. For example, variants may be targeted to loop regions of the protein which can absorb structural perturbations to a greater extent than helices. As described in Example 5, residues D345, R528 and T536 of P. alba IspS (SEQ ID NO:41) were targets for SEL analysis. Without being bound by theory, D345 may be involved in dimerization of isoprene synthase. R528 adjacent to the flexible loop described above. Residue T536 is located at the C-terminal residue of the last helix on the C-terminal end of isoprene synthase. Variants with improved isoprene synthase activity include, but are not limited to, T536C, T536I, T536F, T536Y, T536A, T536K, T536L, T536R, T536V and T536M.

In some aspects of the invention, the variant isoprene synthase does not contain mutations at homologous residues corresponding to one or more of the following residues in kudzu isoprene synthase: A20, N21, Y22, Q23, P24, N25, L26, E30, F31, Q33, L35, E36, N37, L39, K40, V41, K43, L44, C57, R61, V62, D63, Q65, K87, E94, N95, L99, D100, N105, K137, E138, G143, E144, N182, L184, K185, G187, N189, T190, P225, H226, K247, T257, E258, M259, D266, R271, W278, C291, F299, V302, Y309, D310, N334, D353, S357, I358I, E361, L377, F381, E384, N389, I392, I393, K398, Y399, E401, N402, A403, S406, S407, S408, G409, A411, L413, C421, Q423, Q424, E425, D426, H430, L432, R433, S434, D437, R443, C446, F449, A456, T457, S458, A459, A460, E461, L462, E463, R464, G465, E466, T467, T468, N469, H476, N478, D479, Q485, D508, P513, A515, M523, S527, Y531, Q532, Y533, L537, G538, R539, Y542, A543, and P557 (based on FIG. 37; SEQ ID NO:42).

In other aspects of the invention, the variant isoprene synthase does not contain mutations at homologous residues corresponding to one or more of the following residues in P. alba v tremuloides isoprene synthase: K272, R274, W281, F302, V305, Y312, D313, L380, F384, E387, Y402, N404, A406, S409, S410, S411, G412, L414, Q415, L416, F449, N453, L454, A455, S456, A457, S4548, A459, E460, I461, A462, R463, G464, E465, T466, N469, C497, L521, S525, S537, E540, and residues 22 to 27 (based on FIG. 38; SEQ ID NO:43).

In other aspects of the invention, the variant isoprene synthase does not contain mutations at homologous residues corresponding to one or more of the following mutations in P. alba isoprene synthase: V10M, F125, T15A, E18G, V58I, V58F, L70Q, L70V, L70T, T71P, V79L, E89D, G94A, S119F, F120L, G127R, E175V, T212I, S257A, R262G, A266G, F280L, N297K, F305L, L319M, E323K, A328T, D342E, A359T, K366N, E368D, L374M, S396T, V4185, K438N, H440R, T442I, T442A, I449V, A469S, K500R, K505Q, G5075, 5509N, F511Y, and N532K (based on SEQ ID NO:16).

In some aspects of the invention, the variant isoprene synthase does not contain combinations of mutations at homologous residues corresponding to one or more of the following combination mutations in a single P. alba isoprene synthase: G127R/F511Y, L70Q/G94A/R262G/F305L, F12S/T15A/E18G/N297K, S396T/T442I, V10M/E323K, F120L/A266G, K438N/K500R, V79L/S509N, E175V/S257A/E368D/A469S, T71P/L374M, F280L/H440R, E89D/H440R, V58F/A328T/N532K, S119F/D342E/I449V, and K366N/G507S (based on SEQ ID NO:16).

It has been shown that mutating amino-acid residues on the surface of protease enzymes can improve their activity, expression, and stability (WO2008/153925, WO2008/153934, WO2008/153935). Surprisingly, we have found that mutating amino-acid residues on the surface of a completely different enzyme, isoprene synthase, can enhance its expression, solubility, and activity. L70R is an example of such a beneficial surface mutation.

Elucidation of the three-dimensional structure of an enzyme is essential for accurately identifying amino-acid residues on its surface. Homology modeling using structures with sequences approximately 40% identical to isoprene synthase (e.g., bornyl synthase and limonene synthase, the enzymes of known structure with closest identity to isoprene synthase) can reveal gross aspects of the modeled enzyme structure, but is insufficient to precisely identify surface-exposed residues and quantify their degree of surface exposure. Surface exposure of an amino-acid residue is quantified by the percentage of solvent-accessible surface area of its side chain.

The following classes of mutations in isoprene synthase may improve solubility of the enzyme by targeting amino-acid residues that are about >50% solvent-exposed, in some cases about >65% solvent-exposed, and in other cases >85% solvent-exposed:

-   -   Hydrophobic→positively charged, and vice versa     -   Hydrophobic→negatively charged, and vice versa     -   Hydrophobic→neutral polar, and vice versa     -   Neutral polar→positively charged, and vice versa     -   Neutral polar→negatively charged, and vice versa     -   Positively charged→negatively charged, and vice versa

These classes of mutations may also be used to improve the activity, substrate stability, dimerization of isoprene synthase.

The three-dimensional structure of isoprene synthase reveals the structural reaction coordinates of isoprene synthesis. As such, the invention provides a three-dimensional configuration of atoms involved in the catalytic conversion of DMAPP to isoprene. In some aspects, the invention provides an agent comprising a three-dimensional configuration of atoms for the catalytic conversion of DMAPP to isoprene. Example of agents include, but are not limited to, synthetic molecules including synthetic polypeptides as well as re-engineered polypeptides. For example, other members of the terpene synthase family may be altered to comprise the three-dimensional configuration of atoms for the catalytic conversion of DMAPP to isoprene.

Machine Readable Storage Media

Transformation of the structure coordinates for all or a portion of P. tremuloides isoprene synthase or an isoprene synthase/ligand complex or one of its active sites, for structurally homologous molecules, or for the structural equivalents of any of these molecules or molecular complexes as defined above, into three-dimensional graphical representations of the molecule or complex can be conveniently achieved through the use of commercially-available software.

The invention thus further provides a machine-readable storage medium including a data storage material encoded with machine readable data which, when using a machine programmed with instructions for using said data, displays a graphical three-dimensional representation of any of the molecule or molecular complexes of this invention that have been described above. In a preferred embodiment, the machine-readable data storage medium includes a data storage material encoded with machine readable data which, when using a machine programmed with instructions for using said data, displays a graphical three-dimensional representation of a molecule or molecular complex including all or any parts of a P. tremuloides isoprene synthase active site or a P. tremuloides-like active site; for example from a poplar isoprene synthase including but not limited to P. alba isoprene synthase, as defined above. In another aspect, the machine-readable data storage medium displays a graphical three-dimensional representation of a molecule or molecular complex defined by the structure coordinates of all of the amino acids in Table 3-7, ±a root mean square deviation from the backbone atoms of said amino acids of not more than 1.5 Å. In another aspect, the machine-readable data storage medium displays a graphical three-dimensional representation of a molecule or molecular complex defined by the structure coordinates of all of the amino acids in Table 4-2, ±a root mean square deviation from the backbone atoms of said amino acids of not more than 1.5 Å.

In an alternative aspect of the invention, the machine-readable data storage medium includes a data storage material encoded with a first set of machine readable data which includes the Fourier transform of the structure coordinates set forth in Table 3-7 or 4-2, and which, when using a machine programmed with instructions for using said data, can be combined with a second set of machine readable data including the x-ray diffraction pattern of a molecule or molecular complex to determine at least a portion of the structure coordinates corresponding to the second set of machine readable data.

For example, a system for reading a data storage medium may include a computer including a central processing unit (“CPU”), a working memory which may be, e.g., RAM (random access memory) or “core” memory, mass storage memory (such as one or more disk drives or CD-ROM drives), one or more display devices (e.g., cathode-ray tube (“CRT”) displays, light emitting diode (“LED”) displays, liquid crystal displays (“LCDs”), electroluminescent displays, vacuum fluorescent displays, field emission displays (“FEDs”), plasma displays, projection panels, etc.), one or more user input devices (e.g., keyboards, microphones, mice, touch screens, etc.), one or more input lines, and one or more output lines, all of which are interconnected by a conventional bidirectional system bus. The system may be a stand-alone computer, or may be networked (e.g., through local area networks, wide area networks, intranets, extranets, or the internet) to other systems (e.g., computers, hosts, servers, etc.). The system may also include additional computer controlled devices such as consumer electronics and appliances.

Input hardware may be coupled to the computer by input lines and may be implemented in a variety of ways. Machine-readable data of this invention may be inputted via the use of a modem or modems connected by a telephone line or dedicated data line. Alternatively or additionally, the input hardware may include CD-ROM drives or disk drives. In conjunction with a display terminal, a keyboard may also be used as an input device.

Output hardware may be coupled to the computer by output lines and may similarly be implemented by conventional devices. By way of example, the output hardware may include a display device for displaying a graphical representation of an active site of this invention using a program such as QUANTA. Output hardware might also include a printer, so that hard copy output may be produced, or a disk drive, to store system output for later use.

In operation, a CPU coordinates the use of the various input and output devices, coordinates data accesses from mass storage devices, accesses to and from working memory, and determines the sequence of data processing steps. A number of programs may be used to process the machine-readable data of this invention. Such programs are discussed in reference to the computational methods of drug discovery as described herein. References to components of the hardware system are included as appropriate throughout the following description of the data storage medium.

Machine-readable storage devices useful in the present invention include, but are not limited to, magnetic devices, electrical devices, optical devices, and combinations thereof. Examples of such data storage devices include, but are not limited to, hard disk devices, CD devices, digital video disk devices, floppy disk devices, removable hard disk devices, magneto-optic disk devices, magnetic tape devices, flash memory devices, bubble memory devices, holographic storage devices, and any other mass storage peripheral device. It should be understood that these storage devices include necessary hardware (e.g., drives, controllers, power supplies, etc.) as well as any necessary media (e.g., disks, flash cards, etc.) to enable the storage of data.

Isoprene Synthase Variants, Agents with Similar 3-D Structures, and their Use

Compositions and methods to make and use variants derived from the three-dimensional structure of isoprene synthase and agents with similar three-dimensional structure to isoprene synthase are provided herein.

The invention provides methods to generate and test candidate variants of isoprene synthesis based on an evaluation of the three-dimensional structure of the protein. Candidate residues for alteration are derived by a computational analysis of the three-dimensional structure with regard to one or more desired characteristics of the variant; for example, increased specific activity, increased stability, increased expression and the like. Candidate variants may then be generated using standard molecular biology techniques. Variants can be assessed based on the desired outcome. For example, a variant isoprene synthase engineered for increased specific activity can be tested for the conversion of DMAPP to isoprene in vitro with purified or partially purified variant isoprene synthase or in vivo in the context of a host organism such as E. coli. In some cases, the E. coli may also express the DXP pathway, the MVA pathway, or both. Improved activity is assessed in comparison with other isoprene synthases; for example, a wild type isoprene synthase. It is contemplated that enzymes having various degrees of stability, solubility, activity, and/or expression level in one or more of test conditions will find use in the present invention for the production of isoprene in a diversity of hosts. High throughput methods may provide an investigation of these properties in an economical manner.

The invention provides compositions and methods for the production of increased amounts of isoprene. In particular, these compositions and methods increase the rate of isoprene production and increase the total amount of isoprene that is produced. In some aspects of the invention, the amount of isoprene produced by cells may be increased by introducing a heterologous nucleic acid encoding a variant isoprene synthase polypeptide into the cells.

Exemplary Polypeptides and Nucleic Acids

Various isoprene synthase polypeptides and nucleic acids can be used in the compositions and methods of the invention. As used herein, “polypeptides” includes polypeptides, proteins, peptides, fragments of polypeptides, and fusion polypeptides that include part or all of a first polypeptide (e.g., an isoprene synthase) and part or all of a second polypeptide (e.g., a peptide that facilitates purification or detection of the fusion polypeptide, such as a His-tag). In various embodiments, a polypeptide has at least or about 50, 100, 150, 175, 200, 250, 300, 350, 400, or more amino acids. In some embodiments, the polypeptide fragment contains at least or about 25, 50, 75, 100, 150, 200, 300, or more contiguous amino acids from a full-length polypeptide and has at least or about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 100% or greater than 100% of an activity of a corresponding full-length polypeptide. In particular embodiments, the polypeptide includes a segment of or the entire amino acid sequence of any naturally-occurring isoprene synthase. In some embodiments, the polypeptide has one or more mutations compared to the sequence of a wild-type (i.e., a sequence occurring in nature) isoprene synthase.

In some embodiments, the polypeptide is a heterologous polypeptide. By “heterologous polypeptide” is meant a polypeptide whose amino acid sequence is not identical to that of another polypeptide naturally expressed in the same host cell.

In various embodiments, the nucleic acid is a recombinant nucleic acid. For instance, in some embodiments, an isoprene synthase nucleic acid is operably linked to another nucleic acid encoding all or a portion of another polypeptide such that the recombinant nucleic acid encodes a fusion polypeptide that includes an isoprene synthase and all or part of another polypeptide (e.g., a peptide that facilitates purification or detection of the fusion polypeptide, such as a His-tag). In some embodiments, part or all of a recombinant nucleic acid is chemically synthesized. In some aspects, the nucleic acid is a heterologous nucleic acid. By “heterologous nucleic acid” is meant a nucleic acid whose nucleic acid sequence is not identical to that of another nucleic acid naturally found in the same host cell.

In particular embodiments the nucleic acid includes a segment of or the entire nucleic acid sequence of any naturally-occurring isoprene synthase nucleic acid. In some embodiments, the nucleic acid includes at least or about 50, 100, 150, 200, 300, 400, 500, 600, 700, 800, or more contiguous nucleotides from a naturally-occurring isoprene synthase nucleic acid. In some aspects, the nucleic acid has one or more mutations compared to the sequence of a wild-type (i.e., a sequence occurring in nature) isoprene synthase nucleic acid. In some embodiments, the nucleic acid has one or more mutations (e.g., a silent mutation) that increase the transcription or translation of isoprene synthase nucleic acid. In some embodiments, the nucleic acid is a degenerate variant of any nucleic acid encoding an isoprene synthase polypeptide.

An isoprene synthase nucleic acid can be incorporated into a vector, such as an expression vector, using standard techniques (Sambrook et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor, 2001, which is hereby incorporated by reference in its entirety, particularly with respect to the screening of appropriate DNA sequences and the construction of vectors). Methods used to ligate the DNA construct comprising a nucleic acid of interest such as isoprene synthase, a promoter, a terminator, and other sequences and to insert them into a suitable vector are well known in the art. Additionally, vectors can be constructed using known recombination techniques (e.g., Invitrogen Life Technologies, Gateway Technology).

In some embodiments, it may be desirable to over-express isoprene synthase nucleic acids at levels far higher than currently found in naturally-occurring cells. This result may be accomplished by the selective cloning of the nucleic acids encoding those polypeptides into multicopy plasmids or placing those nucleic acids under a strong inducible or constitutive promoter. Methods for over-expressing desired polypeptides are common and well known in the art of molecular biology and examples may be found in Sambrook et al., Molecular Cloning: A Laboratory Manual, 2nd ed., Cold Spring Harbor, 2001, which is hereby incorporated by reference in its entirety, particularly with respect to cloning techniques.

The following resources include descriptions of additional general methodology useful in accordance with the invention: Kreigler, Gene Transfer and Expression; A Laboratory Manual, 1990; and Ausubel et al., Eds. Current Protocols in Molecular Biology, 1994, which are each hereby incorporated by reference in their entireties, particularly with respect to molecular biology and cloning techniques.

Exemplary Host Cells

A variety of host cells can be used to express isoprene synthase and to produce isoprene in the methods of the claimed invention. The host cell may be a cell that naturally produces isoprene or a cell that does not naturally produce isoprene. In some embodiments, the host cell naturally produces isoprene using the DXP pathway, and an isoprene synthase, DXS, and/or IDI nucleic acid is added to enhance production of isoprene using this pathway. In some embodiments, the host cell naturally produces isoprene using the MVA pathway, and an isoprene synthase and/or one or more MVA pathway nucleic acids are added to enhance production of isoprene using this pathway. In some embodiments, the host cell naturally produces isoprene using the DXP pathway and one or more MVA pathway nucleic acids are added to produce isoprene using part or all of the MVA pathway as well as the DXP pathway. In some embodiments, the host cell naturally produces isoprene using both the DXP and MVA pathways and one or more isoprene synthase, DXS, IDI, or MVA pathway nucleic acids are added to enhance production of isoprene by one or both of these pathways.

Other exemplary host cells that can be used are described in US Pub. 2009/0203102, WO 2009/076676, WO 2010/003007, WO 2009/132220, WO 2010/031062, WO 2010/031068, WO 2010/031076, WO 2010/031077, and WO 2010/031079.

Exemplary Transformation Methods

Isoprene synthase, DXS, IDI, and/or MVA pathway nucleic acids or vectors containing them can be inserted into a host cell (e.g., a bacterial cell) using standard techniques for expression of the encoded isoprene synthase, DXS, IDI, and/or MVA pathway polypeptide. Introduction of a DNA construct or vector into a host cell can be performed using techniques such as transformation, electroporation, nuclear microinjection, transduction, transfection (e.g., lipofection mediated or DEAE-Dextrin mediated transfection or transfection using a recombinant phage virus), incubation with calcium phosphate DNA precipitate, high velocity bombardment with DNA-coated microprojectiles, and protoplast fusion. General transformation techniques are known in the art (see, e.g., Current Protocols in Molecular Biology (F. M. Ausubel et al. (eds) Chapter 9, 1987; Sambrook et al., Molecular Cloning: A Laboratory Manual, 3rd ed., Cold Spring Harbor, 2001; and Campbell et al., Curr Genet, 16:53-56, 1989, which are each hereby incorporated by reference in their entireties, particularly with respect to transformation methods). The introduced nucleic acids may be integrated into chromosomal DNA or maintained as extrachromosomal replicating sequences.

Other exemplary transformation methods that can be used are described in US Pub. 2009/0203102, WO 2009/076676, WO 2010/003007, WO 2009/132220, WO 2010/031062, WO 2010/031068, WO 2010/031076, WO 2010/031077, and WO 2010/031079.

Exemplary Cell Culture Media

Any carbon source can be used to cultivate the host cells. The term “carbon source” refers to one or more carbon-containing compounds capable of being metabolized by a host cell or organism. For example, the cell medium used to cultivate the host cells may include any carbon source suitable for maintaining the viability or growing the host cells.

In some embodiments, the carbon source is a carbohydrate (such as monosaccharide, disaccharide, oligosaccharide, or polysaccharides), invert sugar (e.g., enzymatically treated sucrose syrup), glycerol, glycerine (e.g., a glycerine byproduct of a biodiesel or soap-making process), dihydroxyacetone, one-carbon source, fatty acid (e.g., a saturated fatty acid, unsaturated fatty acid, or polyunsaturated fatty acid), lipid, phospholipid, glycerolipid, monoglyceride, diglyceride, triglyceride, polypeptide (e.g., a microbial or plant protein or peptide), renewable carbon source (e.g., a biomass carbon source such as a hydrolyzed biomass carbon source; beet sugar or cane sugar molasses), yeast extract, component from a yeast extract, polymer, acid, alcohol, aldehyde, ketone, amino acid, succinate, lactate, acetate, ethanol, or any combination of two or more of the foregoing. In some embodiments, the carbon source is a product of photosynthesis, including, but not limited to, glucose.

Exemplary monosaccharides include glucose and fructose; exemplary oligosaccharides include lactose and sucrose, and exemplary polysaccharides include starch and cellulose. Exemplary carbohydrates include C6 sugars (e.g., fructose, mannose, galactose, or glucose) and C5 sugars (e.g., xylose or arabinose). In some embodiments, the cell medium includes a carbohydrate as well as a carbon source other than a carbohydrate (e.g., glycerol, glycerine, dihydroxyacetone, one-carbon source, fatty acid, lipid, phospholipid, glycerolipid, monoglyceride, diglyceride, triglyceride, renewable carbon source, or a component from a yeast extract). In some embodiments, the cell medium includes a carbohydrate as well as a polypeptide (e.g., a microbial or plant protein or peptide). In some embodiments, the microbial polypeptide is a polypeptide from yeast or bacteria. In some embodiments, the plant polypeptide is a polypeptide from soy, corn, canola, jatropha, palm, peanut, sunflower, coconut, mustard, rapeseed, cottonseed, palm kernel, olive, safflower, sesame, or linseed.

In some embodiments, the concentration of the carbohydrate is at least or about 5 grams per liter of broth (g/L, wherein the volume of broth includes both the volume of the cell medium and the volume of the cells), such as at least or about 10, 15, 20, 30, 40, 50, 60, 80, 100, 150, 200, 300, 400, or more g/L. In some embodiments, the concentration of the carbohydrate is between about 50 and about 400 g/L, such as between about 100 and about 360 g/L, between about 120 and about 360 g/L, or between about 200 and about 300 g/L. In some embodiments, this concentration of carbohydrate includes the total amount of carbohydrate that is added before and/or during the culturing of the host cells.

Exemplary lipids are any substance containing one or more fatty acids that are C4 and above fatty acids that are saturated, unsaturated, or branched.

Exemplary fatty acids include compounds of the formula R—COOH, where “R” is a hydrocarbon. Exemplary unsaturated fatty acids include compounds where “R” includes at least one carbon-carbon double bond. Exemplary unsaturated fatty acids include, but are not limited to, oleic acid, vaccenic acid, linoleic acid, palmitelaidic acid, and arachidonic acid. Exemplary polyunsaturated fatty acids include compounds where “R” includes a plurality of carbon-carbon double bonds. Exemplary saturated fatty acids include compounds where “R” is a saturated aliphatic group. In some embodiments, the carbon source includes one or more C12-C22 fatty acids, such as a C12 saturated fatty acid, a C14 saturated fatty acid, a C16 saturated fatty acid, a C18 saturated fatty acid, a C20 saturated fatty acid, or a C22 saturated fatty acid. In an exemplary embodiment, the fatty acid is palmitic acid. In some embodiments, the carbon source is a salt of a fatty acid (e.g., an unsaturated fatty acid), a derivative of a fatty acid (e.g., an unsaturated fatty acid), or a salt of a derivative of fatty acid (e.g., an unsaturated fatty acid). Suitable salts include, but are not limited to, lithium salts, potassium salts, sodium salts, and the like. Di- and triglycerols are fatty acid esters of glycerol.

In some embodiments, the concentration of the lipid, fatty acid, monoglyceride, diglyceride, or triglyceride is at least or about 1 gram per liter of broth (g/L, wherein the volume of broth includes both the volume of the cell medium and the volume of the cells), such as at least or about 5, 10, 15, 20, 30, 40, 50, 60, 80, 100, 150, 200, 300, 400, or more g/L. In some embodiments, the concentration of the lipid, fatty acid, monoglyceride, diglyceride, or triglyceride is between about 10 and about 400 g/L, such as between about 25 and about 300 g/L, between about 60 and about 180 g/L, or between about 75 and about 150 g/L. In some embodiments, the concentration includes the total amount of the lipid, fatty acid, monoglyceride, diglyceride, or triglyceride that is added before and/or during the culturing of the host cells. In some embodiments, the carbon source includes both (i) a lipid, fatty acid, monoglyceride, diglyceride, or triglyceride and (ii) a carbohydrate, such as glucose. In some embodiments, the ratio of the lipid, fatty acid, monoglyceride, diglyceride, or triglyceride to the carbohydrate is about 1:1 on a carbon basis (i.e., one carbon in the lipid, fatty acid, monoglyceride, diglyceride, or triglyceride per carbohydrate carbon). In particular embodiments, the amount of the lipid, fatty acid, monoglyceride, diglyceride, or triglyceride is between about 60 and 180 g/L, and the amount of the carbohydrate is between about 120 and 360 g/L.

Exemplary microbial polypeptide carbon sources include one or more polypeptides from yeast or bacteria. Exemplary plant polypeptide carbon sources include one or more polypeptides from soy, corn, canola, jatropha, palm, peanut, sunflower, coconut, mustard, rapeseed, cottonseed, palm kernel, olive, safflower, sesame, or linseed.

Exemplary renewable carbon sources include cheese whey permeate, cornsteep liquor, sugar beet molasses, barley malt, and components from any of the foregoing. Exemplary renewable carbon sources also include glucose, hexose, pentose and xylose present in biomass, such as corn, switchgrass, sugar cane, cell waste of fermentation processes, and protein by-product from the milling of soy, corn, or wheat. In some embodiments, the biomass carbon source is a lignocellulosic, hemicellulosic, or cellulosic material such as, but are not limited to, a grass, wheat, wheat straw, bagasse, sugar cane bagasse, soft wood pulp, corn, corn cob or husk, corn kernel, fiber from corn kernels, corn stover, switch grass, rice hull product, or a by-product from wet or dry milling of grains (e.g., corn, sorghum, rye, triticate, barley, wheat, and/or distillers grains). Exemplary cellulosic materials include wood, paper and pulp waste, herbaceous plants, and fruit pulp. In some embodiments, the carbon source includes any plant part, such as stems, grains, roots, or tubers. In some embodiments, all or part of any of the following plants are used as a carbon source: corn, wheat, rye, sorghum, triticate, rice, millet, barley, cassaya, legumes, such as beans and peas, potatoes, sweet potatoes, bananas, sugarcane, and/or tapioca. In some embodiments, the carbon source is a biomass hydrolysate, such as a biomass hydrolysate that includes both xylose and glucose or that includes both sucrose and glucose.

In some embodiments, the renewable carbon source (such as biomass) is pretreated before it is added to the cell culture medium. In some embodiments, the pretreatment includes enzymatic pretreatment, chemical pretreatment, or a combination of both enzymatic and chemical pretreatment (see, for example, Farzaneh et al., Bioresource Technology 96 (18): 2014-2018, 2005; U.S. Pat. No. 6,176,176; U.S. Pat. No. 6,106,888; which are each hereby incorporated by reference in their entireties, particularly with respect to the pretreatment of renewable carbon sources). In some embodiments, the renewable carbon source is partially or completely hydrolyzed before it is added to the cell culture medium.

In some embodiments, the renewable carbon source (such as corn stover) undergoes ammonia fiber expansion (AFEX) pretreatment before it is added to the cell culture medium (see, for example, Farzaneh et al., Bioresource Technology 96 (18): 2014-2018, 2005). During AFEX pretreatment, a renewable carbon source is treated with liquid anhydrous ammonia at moderate temperatures (such as about 60 to about 100° C.) and high pressure (such as about 250 to about 300 psi) for about 5 minutes. Then, the pressure is rapidly released. In this process, the combined chemical and physical effects of lignin solubilization, hemicellulose hydrolysis, cellulose decrystallization, and increased surface area enables near complete enzymatic conversion of cellulose and hemicellulose to fermentable sugars. AFEX pretreatment has the advantage that nearly all of the ammonia can be recovered and reused, while the remaining serves as nitrogen source for microbes in downstream processes. Also, a wash stream is not required for AFEX pretreatment. Thus, dry matter recovery following the AFEX treatment is essentially 100%. AFEX is basically a dry-to-dry process. The treated renewable carbon source is stable for long periods and can be fed at very high solid loadings in enzymatic hydrolysis or fermentation processes. Cellulose and hemicellulose are well preserved in the AFEX process, with little or no degradation. There is no need for neutralization prior to the enzymatic hydrolysis of a renewable carbon source that has undergone AFEX pretreatment. Enzymatic hydrolysis of AFEX-treated carbon sources produces clean sugar streams for subsequent fermentation use.

In some embodiments, the concentration of the carbon source (e.g., a renewable carbon source) is equivalent to at least or about 0.1, 0.5, 1, 1.5 2, 3, 4, 5, 10, 15, 20, 30, 40, or 50% glucose (w/v). The equivalent amount of glucose can be determined by using standard HPLC methods with glucose as a reference to measure the amount of glucose generated from the carbon source. In some embodiments, the concentration of the carbon source (e.g., a renewable carbon source) is equivalent to between about 0.1 and about 20% glucose, such as between about 0.1 and about 10% glucose, between about 0.5 and about 10% glucose, between about 1 and about 10% glucose, between about 1 and about 5% glucose, or between about 1 and about 2% glucose.

In some embodiments, the carbon source includes yeast extract or one or more components of yeast extract. In some embodiments, the concentration of yeast extract is at least 1 gram of yeast extract per liter of broth (g/L, wherein the volume of broth includes both the volume of the cell medium and the volume of the cells), such at least or about 5, 10, 15, 20, 30, 40, 50, 60, 80, 100, 150, 200, 300, or more g/L. In some embodiments, the concentration of yeast extract is between about 1 and about 300 g/L, such as between about 1 and about 200 g/L, between about 5 and about 200 g/L, between about 5 and about 100 g/L, or between about 5 and about 60 g/L. In some embodiments, the concentration includes the total amount of yeast extract that is added before and/or during the culturing of the host cells. In some embodiments, the carbon source includes both yeast extract (or one or more components thereof) and another carbon source, such as glucose. In some embodiments, the ratio of yeast extract to the other carbon source is about 1:5, about 1:10, or about 1:20 (w/w).

Additionally the carbon source may also be one-carbon substrates such as carbon dioxide, or methanol. Glycerol production from single carbon sources (e.g., methanol, formaldehyde, or formate) has been reported in methylotrophic yeasts (Yamada et al., Agric. Biol. Chem., 53(2) 541-543, 1989, which is hereby incorporated by reference in its entirety, particularly with respect to carbon sources) and in bacteria (Hunter et. al., Biochemistry, 24, 4148-4155, 1985, which is hereby incorporated by reference in its entirety, particularly with respect to carbon sources). These organisms can assimilate single carbon compounds, ranging in oxidation state from methane to formate, and produce glycerol. The pathway of carbon assimilation can be through ribulose monophosphate, through serine, or through xylulose-momophosphate (Gottschalk, Bacterial Metabolism, Second Edition, Springer-Verlag: New York, 1986, which is hereby incorporated by reference in its entirety, particularly with respect to carbon sources). The ribulose monophosphate pathway involves the condensation of formate with ribulose-5-phosphate to form a six carbon sugar that becomes fructose and eventually the three carbon product glyceraldehyde-3-phosphate. Likewise, the serine pathway assimilates the one-carbon compound into the glycolytic pathway via methylenetetrahydrofolate.

In addition to one and two carbon substrates, methylotrophic organisms are also known to utilize a number of other carbon containing compounds such as methylamine, glucosamine and a variety of amino acids for metabolic activity. For example, methylotrophic yeast are known to utilize the carbon from methylamine to form trehalose or glycerol (Bellion et al., Microb. Growth Cl Compd., Int. Symp., 7th ed., 415-32. Editors: Murrell et al., Publisher: Intercept, Andover, UK, 1993, which is hereby incorporated by reference in its entirety, particularly with respect to carbon sources). Similarly, various species of Candida metabolize alanine or oleic acid (Sulter et al., Arch. Microbiol. 153(5), 485-9, 1990, which is hereby incorporated by reference in its entirety, particularly with respect to carbon sources).

In some embodiments, cells are cultured in a standard medium containing physiological salts and nutrients (see, e.g., Pourquie, J. et al., Biochemistry and Genetics of Cellulose Degradation, eds. Aubert et al., Academic Press, pp. 71-86, 1988; and Ilmen et al., Appl. Environ. Microbiol. 63:1298-1306, 1997, hereby incorporated by reference, particularly with respect to cell media). Exemplary growth media are common commercially prepared media such as Luria Bertani (LB) broth, Sabouraud Dextrose (SD) broth, or Yeast medium (YM) broth. One skilled in the art of microbiology or fermentation science would know other defined or synthetic growth media that may also be used, and the appropriate medium for growth of particular host cells.

In addition to an appropriate carbon source, the cell medium desirably contains suitable minerals, salts, cofactors, buffers, and other components known to those skilled in the art suitable for the growth of the cultures or the enhancement of isoprene production (see, for example, WO 2004/033646 and references cited therein and WO 96/35796 and references cited therein, which are each hereby incorporated by reference in their entireties, particularly with respect to cell medias and cell culture conditions). In some embodiments where an isoprene synthase, DXS, IDI, and/or MVA pathway nucleic acid is under the control of an inducible promoter, the inducing agent (e.g., a sugar, metal salt or antimicrobial), is desirably added to the medium at a concentration effective to induce expression of an isoprene synthase, DXS, IDI, and/or MVA pathway polypeptide. In some embodiments, cell medium has an antibiotic (such as kanamycin) that corresponds to the antibiotic resistance nucleic acid (such as a kanamycin resistance nucleic acid) on a vector that has one or more DXS, IDI, or MVA pathway nucleic acids.

Other exemplary cell culture media that can be used are described in US Pub. 2009/0203102, WO 2009/076676, WO 2010/003007, WO 2009/132220, WO 2010/031062, WO 2010/031068, WO 2010/031076, WO 2010/031077, and WO 2010/031079.

Exemplary Production of Isoprene

In some embodiments, the cells are cultured in a culture medium under conditions permitting the production of isoprene by the cells. In some embodiments, the cells in culture produce isoprene at greater than or about 1, 10, 25, 50, 100, 150, 200, 250, 300, 400, 500, 600, 700, 800, 900, 1,000, 1,250, 1,500, 1,750, 2,000, 2,500, 3,000, 4,000, 5,000, or more nmole of isoprene/gram of cells for the wet weight of the cells/hour (nmole/gwcm/hr). In some embodiments, the amount of isoprene is between about 2 to about 5,000 nmole/gwcm/hr, such as between about 2 to about 100 nmole/gwcm/hr, about 100 to about 500 nmole/gwcm/hr, about 150 to about 500 nmole/gwcm/hr, about 500 to about 1,000 nmole/gwcm/hr, about 1,000 to about 2,000 nmole/gwcm/hr, or about 2,000 to about 5,000 nmole/gwcm/hr. The amount of isoprene in units of nmole/gwcm/hr can be measured as disclosed in U.S. Pat. No. 5,849,970, which is hereby incorporated by reference in its entirety, particularly with respect to the measurement of isoprene production. For example, two mL of headspace (e.g., headspace from a culture such as 2 mL of culture cultured in sealed vials at 32° C. with shaking at 200 rpm for approximately 3 hours) are analyzed for isoprene using a standard gas chromatography system, such as a system operated isothermally (85° C.) with an n-octane/porasil C column (Alltech Associates, Inc., Deerfield, Ill.) and coupled to a RGD2 mercuric oxide reduction gas detector (Trace Analytical, Menlo Park, Calif.) (see, e.g., Greenberg et al, Atmos. Environ. 27A: 2689-2692, 1993; Silver et al., Plant Physiol. 97:1588-1591, 1991, which are each hereby incorporated by reference in their entireties, particularly with respect to the measurement of isoprene production). The gas chromatography area units are converted to nmol isoprene via a standard isoprene concentration calibration curve. In some embodiments, the value for the grams of cells for the wet weight of the cells is calculated by obtaining the A₆₀₀ value for a sample of the cell culture, and then converting the A₆₀₀ value to grams of cells based on a calibration curve of wet weights for cell cultures with a known A₆₀₀ value. In some embodiments, the grams of the cells is estimated by assuming that one liter of broth (including cell medium and cells) with an A₆₀₀ value of 1 has a wet cell weight of 1 gram. The value is also divided by the number of hours the culture has been incubating for, such as three hours.

In some embodiments, the cells in culture produce isoprene at greater than or about 1, 10, 25, 50, 100, 150, 200, 250, 300, 400, 500, 600, 700, 800, 900, 1,000, 1,250, 1,500, 1,750, 2,000, 2,500, 3,000, 4,000, 5,000, 10,000, 100,000, or more ng of isoprene/gram of cells for the wet weight of the cells/hr (ng/gwcm/h). In some embodiments, the amount of isoprene is between about 2 to about 5,000 ng/gwcm/h, such as between about 2 to about 100 ng/gwcm/h, about 100 to about 500 ng/gwcm/h, about 500 to about 1,000 ng/gwcm/h, about 1,000 to about 2,000 ng/gwcm/h, or about 2,000 to about 5,000 ng/gwcm/h. The amount of isoprene in ng/gwcm/h can be calculated by multiplying the value for isoprene production in the units of nmole/gwcm/hr discussed above by 68.1 (as described in Equation 5 below).

In some embodiments, the cells in culture produce a cumulative titer (total amount) of isoprene at greater than or about 1, 10, 25, 50, 100, 150, 200, 250, 300, 400, 500, 600, 700, 800, 900, 1,000, 1,250, 1,500, 1,750, 2,000, 2,500, 3,000, 4,000, 5,000, 10,000, 50,000, 100,000, or more mg of isoprene/L of broth (mg/L broth, wherein the volume of broth includes the volume of the cells and the cell medium). In some embodiments, the amount of isoprene is between about 2 to about 5,000 mg/L broth, such as between about 2 to about 100 mg/L broth, about 100 to about 500 mg/L broth, about 500 to about 1,000 mg/L broth, about 1,000 to about 2,000 mg/L broth, or about 2,000 to about 5,000 mg/L broth. The specific productivity of isoprene in mg of isoprene/L of headspace from shake flask or similar cultures can be measured by taking a 1 ml sample from the cell culture at an OD₆₀₀ value of approximately 1.0, putting it in a 20 mL vial, incubating for 30 minutes, and then measuring the amount of isoprene in the headspace. If the OD₆₀₀ value is not 1.0, then the measurement can be normalized to an OD₆₀₀ value of 1.0 by dividing by the OD₆₀₀ value. The value of mg isoprene/L headspace can be converted to mg/Lbroth/hr/OD₆₀₀ of culture broth by multiplying by a factor of 38. The value in units of mg/Lbroth/hr/OD₆₀₀ can be multiplied by the number of hours and the OD₆₀₀ value to obtain the cumulative titer in units of mg of isoprene/L of broth.

The instantaneous isoprene production rate in mg/L broth/hr in a fermentor can be measured by taking a sample of the fermentor off-gas, analyzing it for the amount of isoprene (in units such as mg of isoprene per L of gas), and multiplying this value by the rate at which off-gas is passed though each liter of broth (e.g., at 1 vvm (volume of air/volume of broth/minute) this is 60 Lgas per hour). Thus, an off-gas level of 1 mg/Lgas corresponds to an instantaneous production rate of 60 mg/Lbroth/hr at air flow of 1 vvm. If desired, the value in the units mg/Lbroth/hr can be divided by the OD₆₀₀ value to obtain the specific rate in units of mg/Lbroth/hr/OD. The average value of mg isoprene/Lgas can be converted to the total product productivity (grams of isoprene per liter of fermentation broth, mg/Lbroth) by multiplying this average off-gas isoprene concentration by the total amount of off-gas sparged per liter of fermentation broth during the fermentation. Thus, an average off-gas isoprene concentration of 0.5 mg/Lbroth/hr over 10 hours at 1 vvm corresponds to a total product concentration of 300 mg isoprene/Lbroth.

In some embodiments, the cells in culture convert greater than or about 0.0015, 0.002, 0.005, 0.01, 0.02, 0.05, 0.1, 0.12, 0.14, 0.16, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.2, 1.4, or 1.6% of the carbon in the cell culture medium into isoprene. In some embodiments, the percent conversion of carbon into isoprene is between about 0.002 to about 1.6%, such as about 0.002 to about 0.005%, about 0.005 to about 0.01%, about 0.01 to about 0.05%, about 0.05 to about 0.15%, 0.15 to about 0.2%, about 0.2 to about 0.3%, about 0.3 to about 0.5%, about 0.5 to about 0.8%, about 0.8 to about 1.0%, or about 1.0 to about 1.6%. The percent conversion of carbon into isoprene (also referred to as “% carbon yield”) can be measured by dividing the moles carbon in the isoprene produced by the moles carbon in the carbon source (such as the moles of carbon in batched and fed glucose and yeast extract). This number is multiplied by 100% to give a percentage value (as indicated in Equation 1). % Carbon Yield=(moles carbon in isoprene produced)/(moles carbon in carbon source)*100  Equation 1

For this calculation, yeast extract can be assumed to contain 50% w/w carbon. % Carbon Yield=(39.1 g isoprene*1/68.1 mol/g*5 C/mol)/[(181221 g glucose*1/180 mol/g*6 C/mol)+(17780 g yeast extract*0.5*1/12 mol/g)]*100=0.042%  Equation 2

One skilled in the art can readily convert the rates of isoprene production or amount of isoprene produced into any other units. Exemplary equations are listed below for interconverting between units.

Units for Rate of Isoprene Production (Total and Specific) 1 g isoprene/L_(broth)/hr=14.7 mmol isoprene/L_(broth)/hr (total volumetric rate)  Equation 3 1 nmol isoprene/g_(wcm)/hr=1 nmol isoprene/L_(broth)/hr/OD₆₀₀ (This conversion assumes that one liter of broth with an OD₆₀₀ value of 1 has a wet cell weight of 1 gram.)  Equation 4 1 nmol isoprene/g_(wcm)/hr=68.1 ng isoprene/g_(wcm)/hr (given the molecular weight of isoprene)  Equation 5 1 nmol isoprene/L_(gas) O₂/hr=90 nmol isoprene/L_(broth)/hr (at an O₂ flow rate of 90 L/hr per L of culture broth)  Equation 6 1 μg isoprene/L_(gas) isoprene in off-gas=60 μg isoprene/L_(broth)/hr at a flow rate of 60 L_(gas) per L_(broth) (1 vvm)  Equation 7 Units for Titer (total and specific) 1 nmol isoprene/mg cell protein=150 nmol isoprene/L_(broth)/OD₆₀₀ (This conversion assumes that one liter of broth with an OD₆₀₀ value of 1 has a total cell protein of approximately 150 mg) (specific productivity)  Equation 8 1 g isoprene/L_(broth)=14.7 mmol isoprene/L_(broth) (total titer)  Equation 9

If desired, Equation 10 can be used to convert any of the units that include the wet weight of the cells into the corresponding units that include the dry weight of the cells. Dry weight of cells=(wet weight of cells)/3.3  Equation 10

In some embodiments encompassed by the invention, a cell comprising a heterologous nucleic acid encoding an isoprene synthase polypeptide produces an amount of isoprene that is at least or about 2-fold, 3-fold, 5-fold, 10-fold, 25-fold, 50-fold, 100-fold, 150-fold, 200-fold, 400-fold, or greater than the amount of isoprene produced from a corresponding cell grown under essentially the same conditions without the heterologous nucleic acid encoding the isoprene synthase polypeptide.

In some embodiments encompassed by the invention, a cell comprising a heterologous nucleic acid encoding an isoprene synthase polypeptide and one or more heterologous nucleic acids encoding a DXS, IDI, and/or MVA pathway polypeptide produces an amount of isoprene that is at least or about 2-fold, 3-fold, 5-fold, 10-fold, 25-fold, 50-fold, 100-fold, 150-fold, 200-fold, 400-fold, or greater than the amount of isoprene produced from a corresponding cell grown under essentially the same conditions without the heterologous nucleic acids.

Exemplary Isoprene Purification Methods

In some embodiments, any of the methods described herein further include recovering the isoprene. For example, the isoprene produced using the compositions and methods of the invention can be recovered using standard techniques. such as gas stripping, fractionation, adsorption/desorption, pervaporation, thermal or vacuum desorption of isoprene from a solid phase, or extraction of isoprene immobilized or absorbed to a solid phase with a solvent (see, for example, U.S. Pat. Nos. 4,703,007 and 4,570,029, which are each hereby incorporated by reference in their entireties, particularly with respect to isoprene recovery and purification methods). In some embodiments, the recovery of isoprene involves the isolation of isoprene in a liquid form (such as a neat solution of isoprene or a solution of isoprene in a solvent). Gas stripping involves the removal of isoprene vapor from the fermentation off-gas stream in a continuous manner. Such removal can be achieved in several different ways including, but not limited to, adsorption to a solid phase, partition into a liquid phase, or direct condensation. In some embodiments, membrane enrichment of a dilute isoprene vapor stream above the dew point of the vapor resulting in the condensation of liquid isoprene.

The recovery of isoprene may involve one step or multiple steps. In some embodiments, the removal of isoprene vapor from the fermentation off-gas and the conversion of isoprene to a liquid phase are performed simultaneously. For example, isoprene can be directly condensed from the off-gas stream to form a liquid. In some embodiments, the removal of isoprene vapor from the fermentation off-gas and the conversion of isoprene to a liquid phase are performed sequentially. For example, isoprene may be adsorbed to a solid phase and then extracted from the solid phase with a solvent.

In some embodiments, any of the methods described herein further include purifying the isoprene. For example, the isoprene produced using the compositions and methods of the invention can be purified using standard techniques. Purification refers to a process through which isoprene is separated from one or more components that are present when the isoprene is produced. In some embodiments, the isoprene is obtained as a substantially pure liquid. Examples of purification methods include (i) distillation from a solution in a liquid extractant and (ii) chromatography. As used herein, “purified isoprene” means isoprene that has been separated from one or more components that are present when the isoprene is produced. See, e.g. U.S. Patent Application Publication No. 2009/0203102, PCT publication WO 2009/076676 and U.S. patent application Ser. No. 12/496,573. In some embodiments, the isoprene is at least about 20%, by weight, free from other components that are present when the isoprene is produced. In various embodiments, the isoprene is at least or about 25%, 30%, 40%, 50%, 60%, 70%, 75%, 80%, 90%, 95%, or 99%, by weight, pure. Purity can be assayed by any appropriate method, e.g., by column chromatography, HPLC analysis, or GC-MS analysis.

All publications and patents mentioned in the above specification are herein incorporated by reference. Various modifications and variations of the described method and system of the invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention. Although the invention has been described in connection with specific embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. It is also to be understood that one, some, or all of the properties of the various embodiments described herein may be combined to form other embodiments of the present invention. These and other aspects of the invention will become apparent to one of skill in the art.

EXAMPLES

The examples, which are intended to be purely exemplary of the invention and should therefore not be considered to limit the invention in any way, also describe and detail aspects and embodiments of the invention discussed above. Unless indicated otherwise, temperature is in degrees Centigrade and pressure is at or near atmospheric. The foregoing examples and detailed description are offered by way of illustration and not by way of limitation. All publications, patent applications, and patents cited in this specification are herein incorporated by reference as if each individual publication, patent application, or patent were specifically and individually indicated to be incorporated by reference. In particular, all publications cited herein are expressly incorporated herein by reference for the purpose of describing and disclosing compositions and methodologies which might be used in connection with the invention. Although the foregoing invention has been described in some detail by way of illustration and example for purposes of clarity of understanding, it will be readily apparent to those of ordinary skill in the art in light of the teachings of this invention that certain changes and modifications may be made thereto without departing from the spirit or scope of the appended claims.

Example 1 Construction of MBD Kudzu IspS

This example describes construction of a vector expressing a maltose-binding protein-kudzu isoprene synthase fusion molecule.

I. Construction of pTrcKudzu

A synthetic gene, coding for isoprene synthase (IspS) of the kudzu vine (Pueraria lobata) and codon-optimized for E. coli, was purchased from DNA2.0 (Menlo Park, Calif.) and provided as plasmid p9795 (FIGS. 2 and 3). The Insert was been removed by digestion with BspLU11I/PstI, gel-purified, and religated into NcoI/PstI-digested pTrcHis2B (Invitrogen, Carlsbad, Calif.). The resulting plasmid was named pTrcKudzu (FIGS. 4 and 5). The stop codon in the insert is before the PstI site, which results in a construct in which the His-Tag is not attached to the IspS protein.

II. Construction of Plasmid pMAL-C4X Kudzu

A PCR reaction was performed to amplify the E. coli codon-optimized kudzu gene using plasmid pTrcKudzu as the DNA template, primers EL-959 and EL-960 Table 1-1, 10 mM dNTP (Roche, Indianapolis, Ind.), and Pfu Ultra II Fusion DNA polymerase (Stratagene, La Jolla, Calif.) according to manufacturer's protocol. PCR conditions were as follows: 95° C. for 2 min (first cycle only), 95° C. for 25 sec, 60° C. for 25 sec, 72° C. for 30 sec, and repeat for 28 cycles, with final extension at 72° C. for 1 min. The PCR product was then purified using the QIAquick PCR Purification Kit (Qiagen Inc, Valencia, Calif.).

The kudzu PCR product (1 μg) was digested using EcoRI and HindIII restriction endonucleases (Roche) according to manufacturer's protocol. The digest was incubated 37° C. for 30 minutes to minimize digestion of the internal EcoRI site that is present in the kudzu gene. The digested PCR fragment was then purified using the QIAquick PCR Purification Kit. The vector pMAL-C4X (0.5 μg) (New England Biolabs, Ipswich, Mass.; FIGS. 6 and 7) was digested using EcoRI and HindIII restriction endonucleases (Roche) according to manufacturer's protocol. The digested vector was then gel purified using the QIAquick Gel Extraction Kit (Qiagen Inc). A DNA ligation reaction was performed using T4 DNA ligase (New England Biolabs) with a 5:1 ratio of digested kudzu PCR product to digested pMAL-C4X vector according to manufacturer's protocol. An aliquot of the ligation reaction was then transformed into TOP10 chemically competent cells (Invitrogen Corp). Transformants were selected on LA+50 μg/μl carbenicillin plates.

Screening of transformants containing the kudzu gene was performed by picking colonies and performing PCR with primers EL-957 and EL-966 using PuReTaq Ready-To-Go PCR beads (GE Healthcare, Piscataway, N.J.) according to manufacturer's protocol. PCR conditions were as follows: 95° C. for 2 min (first cycle only), 95° C. for 30 sec, 50° C. for 30 sec, 72° C. for 40 sec, and repeat for 28 cycles, with final extension at 72° C. for 1 min. PCR products were analyzed on a 2% E-gel (Invitrogen Corp) looking for a 600 by fragment. Colonies containing the correct sized PCR product insert were submitted for DNA sequencing using primers EL-950, EL-951, EL-953, and EL-957. DNA sequencing confirmed the construction of plasmid pMAL-C4X Kudzu (FIGS. 8 and 9).

TABLE 1-1 Primer sequences Primer name Primer sequence EL-950 CGGTGAACTGAAAGGTGACGTCC (SEQ ID NO: 22) EL-951 GGACGTTAACGCTATTAACACCCTG (SEQ ID NO: 23) EL-953 CACATCGTCGATCAGCTCCAGC (SEQ ID NO: 24) EL-957 GGTCGTCAGACTGTCGATGAAGCC (SEQ ID NO: 25) EL-959 GCTTATGAATTCTGTGCGACCTCTTCTCAATTTACTCAG (SEQ ID NO: 26) EL-960 GCTTATAAGCTTAGACATACATCAGCTGGTTAATCGGG (SEQ ID NO: 27) EL-966 CTCCTCCAGCAGGTTCTCACC (SEQ ID NO: 28) III. Expression Strain MBP-Kudzu

Plasmid pMAL-C4X Kudzu was transformed into OneShot BL21(λDE3) chemically competent cells (Invitrogen Corp). Expression strain transformants were selected on LA+50 mg/ml carbenicillin plates.

Example 2 IspS Variants for Crystal Structure Trials

This example describes methods to generate affinity tagged isoprene synthase (IspS) enzymes for expression, purification and crystallization.

I. Strain Construction

For constructs in the pET200D-TOPO vector (Invitrogen), PCR products of the IspS enzymes from P. alba, P. tremuloides, and P. trichocharpa were gel extracted and purified (Qiagen), using 0.8% E-gel (Invitrogen), according to the manufacturer's recommended protocol. PCR reactions for pET200 constructs are as follows: Reaction mixture was 1 μl (Templates)-pET24a-P. alba, 5 μl 10×PfuUltraII Fusion buffer, 1 μl dNTP's (10 mM), 1 μl primer (50 uM) primer F-(MCM219 or 218), 1 μl primer (50 uM) primer R-(MCM182), 41 μl diH₂O and 1 μl of PfuUltra II Fusion DNA Polymerase from Stratagene; Cycle Parameter were 95° C. 1 min., 95° C. 1 min, 55° C. 20 sec., 72° C. 27 sec. for 29 cycles followed by 72° C. for 3 min and then 4° C. until cool, using an Eppendorf Mastercycler. Similar reactions were performed for P. tremuloides, P. trichocarpa, and kudzu. 3 μl of purified product was then ligated to the pET200D/TOPO vector (Invitrogen), according to the manufacturer's protocol. The reaction was incubated for 5 minutes at room temperature, and the 6 μl topoisomerase mixture was then transformed into E. coli Top10 chemically competent cells (Invitrogen) according to the manufacturer's protocol. Transformants were selected for on LB Kan50, and incubated at 37° C. overnight. Five colonies per construct were chosen and screened using PuReTaq Ready-To-Go PCR Beads (Amersham) using the T7 Forward and MCM182 primers (Table 2-1). Clones harboring inserts of the correct size were further verified by plasmid miniprep using the QIAPrep Spin Miniprep kit (Qiagen) followed by sequencing using the T7 Forward and T7 Reverse primers (Quintara Biosciences). One fully sequenced construct for each IspS variant (FIGS. 10-14), was chosen for further study. 1 μl of each plasmid was transformed into BL21(λDE3) pLysS (Invitrogen) according to the manufacturer's protocol. Transformants were selected for on LB medium with Kan50+Cm35 and incubated at 37° C. overnight. The resulting strains were used for expression and purification of various IspS enzymes for crystallography studies.

Construction of an N-terminally 6×His-tagged IspS (in pDu27, see FIG. 22) for protein purification was prepared as follows. The following PCR Reaction mixture was used: 1 μl (Template)-P. alba pET24a, 5 μl 10×PfuUltraII Fusion buffer, 1 μl dNTP's (10 mM), 1 μl primer (50 uM) primer F-(MCM219), 1 μl primer (50 uM) primer R-(MCM182) (Table 2-1), 41 μl diH₂O and 1 μl of PfuUltra II Fusion DNA Polymerase (Stratagene). PCR Cycling Parameters were as follows: 95° C. 1 min., 95° C. 1 min, 55° C. 20 sec., 72° C. 27 sec. for 29 cycles followed by 72° C. for 3 min and 4° C. until cool, using an Eppendorf Mastercycler. The PCR product of the full length P. alba IspS (from the template P. alba pET24a, FIG. 24) was gel extracted and purified, using 0.8% E-gel (Invitrogen) and Qiagen QIAquick Gel Extraction and QIAprep Spin Miniprep kits, according to the manufacturer's recommended protocol. A 3 μl aliquot of purified product was ligated to the pET200D/TOPO vector (Invitrogen), according to the manufacturer's protocol. The reaction was incubated for 5 minutes at room temperature, and the 6 μl topoisomerase mixture was then transformed into E. coli Top10 chemically competent cells (Invitrogen) according to the manufacturer's protocol. Transformants were selected for on LB plates containing kanamycin (50 ug/ml) (Kan50), and incubated at 37° C. overnight. Five colonies were picked and screened using PuReTaq Ready-To-Go PCR Beads (Amersham) using the T7 Forward and MCM182 primers (Table 2-1). Clones harboring inserts of the correct size were further verified by sequencing using the T7 Forward and T7 Reverse primers (Quintara Biosciences). One construct, pDu27 (see FIG. 22), was chosen for further study. A 1 μl aliquot of the plasmid preparation was transformed into BL21(λDE3)pLysS (Invitrogen) according to the manufacturer's protocol. Transformants were selected for on LB plates containing Kan50+ and chloramphenicol (35 μg/ml) (Cm35) and incubated at 37° C. overnight. The resulting strain was used for expression and purification of N-terminally 6×His-tagged P. alba IspS.

Constructs with affinity (6×His) and proteolysis (TEV, Tobacco Etch Virus) tags were generated using P. alba pET24a as a template for PCR reactions. PCR reaction mixtures were prepared as follows: 1 ul (P. alba pET24a), 5 ul 10× PfuUltraII Fusion buffer, 1 ul dNTP's (10 mM), 1 ul primer (50 uM) Alba FL-NdeI-For or Alba TRC (MEA)-NdeI-F, 1 ul primer (50 uM) Alba FLTRC (+) TEV-R, 41 ul diH2O and 1 ul of PfuUltra II Fusion DNA Polymerase from Stratagene. PCR cycling parameters were as follows: 95° C. 1 min., 95° C. 30 sec., 55° C. 20 sec., 72° C. 25 sec. for one cycle and then repeating 95° C. 30 sec., 55° C. 20 sec., 72° C. 25 sec. for an additional 28 cycles, followed by 72° C. 3 min and then 4° C. After amplification and verification of the correct molecular weight of the product by visualization on 0.8% E-gel (Invitrogen), PCR products were digested with restriction enzymes NdeI and XhoI (Roche) for 2 hours at 37° C., and then gel purified using the Qiaquick Gel Purification system (Qiagen) according to the manufacturer's recommended protocol. 3 ul of purified product was ligated to pET-24a (Invitrogen) that was digested with NdeI and XhoI (Roche), gel purified and dephosphorylated (using SAP, shrimp alkaline phosphatase) (Promega) according to the manufacturer's recommended protocols. T4 ligase (NEB) was used for the ligation reaction, which was incubated overnight at 16° C. The ligation reaction was dialyzed into water for 30 min., and 2 μl of the reaction was used to electroporate MCM331 (see below) competent cells. Cells were allowed to recover at 30° C. for 2 hours, and then selected on Kan50 with 5 mM (R)-(−)-Mevalonolactone (MVA) (Sigma) spread onto the plate. Positive transformants were inoculated into 3 ml of liquid LB Kan50, and plasmids were isolated using the QIAPrep Spin miniprep kit (Qiagen). Inserts were verified by restriction digestion using NdeI and XhoI (Roche) and positive clones were sequenced (Quintara Biosciences) with T7 promoter and T7 terminator sequencing primers. 1 μl of each plasmid (see Table 2-3 for plasmid description; FIGS. 15-29) was transformed into chemically competent E. coli BL21(λDE3) pLysS (Invitrogen) according to the manufacturer's recommended protocol. Transformants were selected on LB Kan50+Cm35 (Chloramphenicol 35 ug/ml) plates and incubated at 37° C. See Table 2-4 for a description of all expression strains.

Preparation of strain MCM331

Strain MCM331 was prepared as follows. A synthetic operon containing mevalonate kinase, mevalonate phosphate kinase, mevalonate pyrophosphate decarboxylase, and the IPP isomerase was integrated into the chromosome of E. coli. If desired, expression may be altered by integrating different promoters 5′ of the operon.

i) Target Vector Construction

The attTn7 site was selected for integration. Regions of homology upstream (attTn7 up) (primers MCM78 and MCM79; Table 2-2) and downstream (attTn7 down) (primers MCM88 and MCM89) were amplified by PCR from MG1655 cells. A 50 μL reaction with 1 μL 10 μM primers, 3 μL ddH2O, 45 μL Invitrogen Platinum PCR Supermix High Fidelity, and a scraped colony of MG1655 was denatured for 2:00 at 94° C., cycled 25 times (2:00 at 94° C., 0:30 at 50° C., and 1:00 at 68° C.), extended for 7:00 at 72° C., and cooled to 4° C. This resulting DNA was cloned into pCR2.1 (Invitrogen) according to the manufacturer's instructions, resulting in plasmids MCM278 (attTn7 up) and MCM252 (attTn7 down). The 832 by ApaI-PvuI fragment digested and gel purified from MCM252 was cloned into ApaI-PvuI digested and gel purified plasmid pR6K, creating plasmid MCM276. The 825 bp PstI-NotI fragment digested and gel purified from MCM278 was cloned into PstI-NotI digested and gel purified MCM276, creating plasmid MCM281.

ii) Cloning of Lower Pathway and Promoter

MVK-PMK-MVD-IDI genes were amplified from pTrcKKDyIkIS with primers MCM104 and MCM105 using Roche Expand Long PCR System according to the manufacturer's instructions. This product was digested with NotI and ApaI and cloned into MCM281 which had been digested with NotI and ApaI and gel purified. Primers MCM120 and MCM127 were used to amplify CMR cassette from the GeneBridges FRT-gb2-Cm-FRT template DNA using Stratagene Pfu Ultra II. A PCR program of denaturing at 95° C. for 4:00, 5 cycles of 95° C. for 0:20, 55° C. for 0:20, 72° C. for 2:00, 25 cycles of 95° C. for 0:20, 58° C. for 0:20, 72° C. for 2:00, 72° C. for 10:00, and then cooling to 4° C. was used with four 50 μL PCR reactions containing 1 uL˜10 ng/μL template, 1 μL each primer, 1.25 μL 10 mM dNTPs, 5 μL 10× buffer, 1 μL enzyme, and 39.75 μL ddH20. Reactions were pooled, purified on a Qiagen PCR cleanup column, and used to electroporate water-washed Pir1 cells containing plasmid MCM296. Electroporation was carried out in 2 mM cuvettes at 2.5V and 200 ohms. Electroporation reactions were recovered in LB for 3 hr at 30° C. Transformant MCM330 was selected on LA with CMP5, Kan50.

iii) Integration into E. coli Chromosome

Miniprepped DNA (Qiaquick Spin kit) from MCM330 was digested with SnaBI and used to electroporate BL21(DE3) (Novagen) or MG1655 containing GeneBridges plasmid pRedET Carb. Cells were grown at 30° C. to ˜OD1 then induced with 0.4% L-arabinose at 37° C. for 1.5 hours. These cells were washed three times in 4 C ddH2O before electroporation with 2 μL of DNA. Integrants were selected on L agar with containing chloramphenicol (5 μg/ml) and subsequently confirmed not to grow on L agar+Kanamycin (50 μg/ml). BL21 integrant MCM331 and MG1655 integrant MCM333 were frozen.

TABLE 2-1 Primers MCM219 caccatgcgttgtagcgtgtcca (SEQ ID NO: 29) MCM182 gggcccgtttaaactttaactagactctgcagttagcg ttcaaacggcagaa (SEQ ID NO: 30) MCM218 caccatgcgtcgttctgcgaactac (SEQ ID NO:31)

TABLE 2-2 Primers of construction of MCM331 MCM78 attTn7 up rev for integration gcatgctcgagcggccgcTTTTAATCAAACATCCTGCCAACTC construct (SEQ ID NO: 32) MCM79 attTn7 down rev for integration gatcgaagggcgatcgTGTCACAGTCTGGCGAAACCG construct (SEQ ID NO: 33) MCM88 attTn7 up forw for integration ctgaattctgcagatatcTGTTTTTCCACTCTTCGTTCACTTT construct (SEQ ID NO: 34) MCM89 attTn7 down forw for tctagagggcccAAGAAAAATGCCCCGCTTACG integration construct (SEQ ID NO: 35) MCM104 GI1.2 promoter-MVK Gatcgcggccgcgcccttgacgatgccacatcctgagcaa Ataattcaaccactaattgtgagcggataacacaaggagg Aaacagctatgtcattaccgttcttaacttc (SEQ ID NO: 36) MCM105 aspA terminator-yIDI Gatcgggccccaagaaaaaaggcacgtcatctgacgtgcc Ttttttatttgtagacgcgttgttatagcattcta (SEQ ID NO: 37) MCM120 Forward of attTn7: attTn7 aaagtagccgaagatgacggtttgtcacatggagtt homology, GB marker ggcaggatgtttgattaaaagcAATTAACCCTCACTA homology AAGGGCGG (SEQ ID NO: 38) MCM127 Rev complement of 1.2 GI: GB AGAGTGTTCACCAAAAATAATAACCTTTCCCGGTGCAgaa marker homology(extra long), Gttaagaacggtaatgacatagctgtttcctccttgtgtt promoter, RBS, ATG Atccgctcacaattagtggttgaattatttgctcaggatg tggcatcgtcaagggcTAATACGACTCACTATAGGGCTCG (SEQ ID NO: 39)

TABLE 2-3 Plasmids P. alba pET24a pET24a with “full length” IspS from P. alba P. trichocharpa pET24a pET24a with “full length” IspS from P. trichocharpa P. tremuloides pET24a pET24a with “full length” IspS from P. tremuloides MBP-Kudzu pDu27 P. alba FL-pET200/Top 10 pDu30 P. alba TRC-pET200/Top10 pDu31 P. trem TRC-pET200/Top 10 pDu32 P. trich TRC-pET200/Top10 MD09-161 pET24a-P.alba FL C-Term (+) TEV, His tag/MCM331 MD09-163 pET24a-P.alba TRC (MEA) C-Term (+) TEV, His tag/MCM331

TABLE 2-4 Strains MBP-Kudzu MD08-99 BL21 DE3 pLys + pDu27 MD08-100 BL21 DE3 pLys + pDu30 MD08-102 BL21 DE3 pLys + pDu31 MD08-104 BL21 DE3 pLys + pDu32 MD09-165 BL21(DE3)pLysS, pET24a-P.alba FL C-Term (+) TEV, His tag MD09-167 BL21(DE3) pLysS, pET24a-P.alba TRC (MEA) C-Term (+) TEV, His tag II. Purification of 6×His-Tagged IspS Expression of 6×His-Tagged IspS

N-terminally 6×His-tagged IspS was expressed and purified from strain MD08-99. The growth procedure is suitable for histidine tagged enzymes expressed in BL21(λDE3)pLysS cells. A 10 ml of overnight culture was prepared for each 1 L of planned growth. The appropriate antibiotics (50 mg/ml kanamycin, 50 mg/ml chloramphenicol, and/or 50 mg/ml Carbenecillin) was added to 10 ml of LB medium in a 25 ml flask and was inoculated with 1 colony from a fresh plate of cells or directly from glycerol frozen cell stock. Cultures were grown at 30° C. overnight with shaking at ˜220 rpm. Day cultures were prepared in 1 liter of LB medium with appropriate antibiotics for each culture. Each 1 L Day culture was inoculated with 10 ml of overnight culture and grown at 30-37° C. with shaking at ˜220 rpm until the OD₆₀₀ reached ˜0.4-0.6. Day cultures were then induced with 400 μM IPTG and allowed to continue growing at 30° C. with shaking at 220 rpm for ˜5-6 hours. Cells were then harvested by centrifugation at 10,000×g for 10 min, 4° C. Following Harvest, cells were used directly or stored at −80° C. until ready to process.

Purification of 6×His-Tagged IspS

For purification of histidine tagged enzymes from BL21(λDE3)pLysS cells, cells were gently resuspended in fresh Lysis buffer (Lysis buffer: Ni wash buffer+0.5 mM PMST, 0.01% Tween-20, 1 mg/ml lysozyme, 0.2 mg/ml DNaseI; Ni wash buffer: 50 mM NaH₂PO₄, 300 mM NaCl, 20 mM Imidazole, pH 8.0). Approximately 40-50 ml of lysis buffer was used per 1 L of cell pellet. Cells were then incubated on ice for approximately 30 min. The cell suspension was then lysed fully by passing 2-3 times through a french pressure cell (large french press cell at 1200 psi/High setting) until lysate started to look clear. A sample of the lysate was saved for activity assay and gel analysis (˜100 μl). The lysate was then clarified by centrifuging the lysate at 30,000×g for 30 min, 4° C. in a Sorvall Discovery 90SE ultracentrifuge. The supernatant was removed and retained. A sample of the “clarified lysate” was saved for activity assay and gel analysis (˜100 μl).

The clarified lysate was run over HisTrap HP columns (GE Healthcare) using a gradient from 0-100% Ni buffer B. Samples were then analyzed by SDS-PAGE gel (4-12% gel NUPAGE, Invitrogen) according to manufacturer's directions. Desired fractions were concentrated on spin filters (Vivaspin-20, Sartoris,) and then desalted over a HiPrep 26/10 Desalting column (GE healthcare) packed with Sephadex G25 resin. The G-25 buffer consisted of 50 mM HEPES, 50 mM NaCl, and 1 mM DTT, pH 7.4. The desired sample was then purified over a HiTrap Q HP column (GE) using a gradient elution from 0% Q seph buffer A to 100% Q seph buffer B (Q seph buffer A: 50 mM Tris, 0.05 M NaCl, 1 mM DTT, pH 7.6 and Q seph buffer B: 50 mM Tris, 1.0 M NaCl, 1 mM DTT, pH 7.6). Fractions containing the desired protein were analyzed and concentrated. Sample buffer was then exchanged into 50 mM HEPES, 50 mM NaCL, pH 7.4 with 1 mM DTT by passing the sample over a Hi Prep 26/10 Desalting column (GE healthcare) packed with Sephadex G25 resin. A final polishing step of Gel filtration was used when necessary. The sample was passed through a Hi Load 26/60 Superdex 200 prep grade (GE) in gel filtration buffer: (50 mM HEPES, 150 mM NaCl, 1 mM DTT, pH 7.4). Fractions were then analyzed and concentrated. The samples were then stored at −80° C. For preparation for analysis of the band, the sample is run on an SDS-PAGE gel (4-12% NUPAGE gel, Invitrogen), stained and the desired band excised and processed as described below.

III. Digestion of TEV (Tobacco Etch Virus) or EK (Enterokinase)-Tagged Enzymes

TEV Cleavage (IspS from Strains MD09-165 and MD09-167)

For digestion, enzymes were purified through a Ni charged sepharose (GE Healthcare) and desalted into 50 mM HEPES, 50 mM NaCl pH 7.4 buffer containing 1 mM DTT. Digestion was performed with TurboTEV Protease from Eton Bioscience Inc. One unit of TurboTEV per 10 μg of purified protein was used. The digest was performed at 4° C. overnight. Samples were passed through another Ni column equilibrated in the Ni buffer to remove uncleaved enzyme, tag, TurboTEV protease (that is also tagged) and impurities. The Ni column pass though and washes were analyzed using SDS-PAGE gel (NUPAGE, Invitrogen) and DMAPP activity assays. Samples containing pure enzyme were pooled and desalted into 50 mM NaCl pH 7.4 buffer containing 1 mM DTT and stored at −80° C.

EK Cleavage (IspS from Strains MD08-102 and MD08-104)

For digestion enzymes were purified through a Ni charges sepharose (GE Healthcare) and desalted into 50 mM HEPES, 50 mM NaCl pH 7.4 buffer containing 1 mM DTT.

Digestion was performed with EKMax (E180-02) (Invitrogen) using 1 unit of EKMax per 20 ug of purified protein at 4° C. overnight. Samples were passed over EK Away resin (Invitrogen) to remove excess enterokinase. Samples were batched onto Ni charged sepharose resin (equilibrated in the Ni was buffer) and incubated for 30 min at 4° C., with occasional inverting. This removed uncleaved enzyme, tag, and impurities. The Ni column pass though and washes were analyzed using SDS-PAGE gel (4-12% NUPAGE, Invitrogen) and DMAPP activity assays. Samples containing pure enzyme were pooled and desalted into 50 mM NaCl pH 7.4 buffer containing 1 mM DTT. Stored at −80° C.

IV. Purification of MBP-IspS

Construction of pMAL-C4X Kudzu for the expression of MBP-Kudzu isoprene synthase is described in Example 1. MBP-Kudzu isoprene synthase production from E. coli grown in batch culture at the 15-L scale.

Medium Recipe (Per Liter Fermentation Medium):

K₂HPO₄ 7.5 g, MgSO₄*7H₂O 2 g, citric acid monohydrate 2 g, ferric ammonium citrate 0.3 g, yeast extract 0.5 g, 1000× Modified Trace Metal Solution 1 ml. All of the components were added together and dissolved in diH₂O. This solution was autoclaved. The pH was adjusted to 7.0 with ammonium hydroxide (30%) and q.s. to volume. Glucose 10 g, thiamine*HCl 0.1 g, and antibiotics were added after sterilization and pH adjustment.

1000× Modified Trace Metal Solution:

Citric Acids*H₂O 40 g, MnSO₄*H₂O 30 g, NaCl 10 g, FeSO₄*7H₂O 1 g, CoCl₂*6H₂O 1 g, ZnSO*7H₂O 1 g, CuSO₄*5H₂O 100 mg, H₃BO₃ 100 mg, NaMoO₄*2H₂O 100 mg. Each component is dissolved one at a time in diH₂O, pH to 3.0 with HCl/NaOH, then q.s. to volume and filter sterilized with 0.22 micron filter.

Fermentation was performed in a 15-L bioreactor with BL21 (DE3) E. coli cells containing the pMAL-C4X plasmid expressing a maltose binding protein (MBP)-Kudzu isoprene synthase fusion molecule. This experiment was carried out to produce isoprene synthase at the desired fermentation pH 7.0 and temperature 30° C. A frozen vial of the E. coli strain was thawed and inoculated into tryptone-yeast extract medium. After the inoculum grew to OD 1.0, measured at 550 nm (OD₅₅₀), 120 mL was used to inoculate a 15-L bioreactor bringing the initial volume to 9-L.

Expression of the desired molecule was achieved by adding isopropyl-beta-D-1-thiogalactopyranoside (IPTG). The IPTG concentration was brought to 1 mM when the OD₅₅₀ reached a value of 10. Cells containing the desired product were harvested 3 hrs after IPTG addition.

MBP-IspS Purification

The broth was centrifuged for 15 min at 10000×g. The pellet was collected and frozen at −80° C. until further purification. Cells were resuspended in MBP-Bind Buffer (5% glycerol, 20 mM Tris pH 7.4, 200 mM NaCl, 2 mM DTT, 1 mg/ml lysozyme) and passed through the french press three times at 20000 psi. The lysate was then ultracentrifuged at 100000×g for 1 hour to yield a relatively clear solution. The supernatant was pipetted from the top of the tube without disturbing the gelatinous material on the bottom of the centrifuge tube. Gel filtration was performed on the supernatant using a Superdex-200 26/60 column (GE healthcare). The column was developed using MBP-Bind buffer at a flow rate of 3 mL/min at 23° C. Fractions were tested for DMAPP activity as described below. Active fractions were pooled and loaded onto 25 mL amylose resin (New England Biolabs). The column was washed with 10 column volumes MBP-Bind buffer and the protein was then eluted with 2 column volumes of MBP-Bind buffer containing 10 mM maltose to yield >90% pure MBP-IspS.

V. DMAPP Assay

The following reaction mixture was used for the DMAPP assay: 25 μL lysate mixture, 5 μL MgCl2 (1 M), 5 μL DMAPP (100 mM), and 65 μL 100 mM Tris pH 8, 100 mM NaCl for a total volume of 100 μL. The reaction is performed at 30° C. for 15 minutes in a gas tight 1.8 mL GC tube. Reactions are terminated by the addition of 100 μL 500 mM EDTA (pH 8). The amount of isoprene produced was measured by GC/MS.

The analysis was performed (for the 2 mL and 96-well plate methods) using an Agilent 6890 GC/MS system interfaced with a 5973 MS Leap CTC CombiPAL autosampler operating in headspace mode. An Agilent HP-5 (5% Phenyl Methyl Siloxane (15 m×0.25 mm×0.25 uM)) column was used for separation of analytes. The sampler was set up to inject 100 μL of headspace gas. The GC/MS method utilized helium as the carrier gas at a flow of 1 ml/min. The injection port was held at 250° C. with a split ratio of 50:1. The oven temperature was held at 37° C. for the 2 min duration of the analysis. The Agilent 5793N mass selective detector was run in single ion monitoring (SIM) mode on mass 67. The detector was switched off from 0.00 to 0.44 minutes to allow the elution of permanent gases and on 0.44 mins to 0.60 mins. Under these conditions isoprene (2-methyl-1,3-butadiene) was observed to elute at 0.49 minutes. A calibration table was used to quantify the absolute amount of isoprene and was found to be linear from 0 μg/L to 5600 mg/L (using calibration gas).

Example 3 Three-Dimensional Structure of IspS

Seven constructs of plant isoprene synthase (IspS) were prepared in the hope that one or more would yield crystals suitable for x-ray diffraction. These were: a construct containing N-terminal histidine-tagged maltose binding protein and kudzu IspS (MBP-kudzu), full-length P. alba IspS with N-terminal histidine-tag (MD08-99), P. alba IspS with the first nineteen N-terminal residues removed (MD08-100), this construct also had the N-terminal his-tag removed after purification. Full-length, untagged P. alba IspS (strain RM11608-2). A truncated P. alba IspS construct featuring two additional residues before the twin-arginine motif was generated (MD09-167). P. tricharpa IspS was generated, which contains both an N-terminal his-tag and N-terminal truncation (MD08-104), and another construct composed of IspS from P. tremuloides was generated with an N-terminal his-tag and N-terminal truncation (MD08-102). Construction of strains expressing various isoprene synthases are described above.

Protein from each construct was purified and a concentrated protein solution was then prepared for surveying possible crystallization conditions. Each protein was purified independently and surveyed as described below. All in-house crystallization screens were set up using the hanging drop vapor diffusion method. At a minimum, each protein was surveyed using the following commercial screens: the Crystal Screen from Hampton Research (Aliso Viejo, Calif.) and the JCSG+Suite from Qiagen (Valencia, Calif.).

Purified MBP-kudzu using was set up using the following commercial screens: the Crystal Screen from Hampton Research and the JCSG+Suite from. Additionally, purified MBP-kudzu was sent to the Hauptman-Woodward Institute (Buffalo, N.Y.) for high-throughput screening, where no fewer than 1536 conditions were surveyed. The purified MBP-kudzu fusion precipitated out of solution in the majority of conditions, and no protein crystals were observed.

The next construct used for crystallization screening was MD08-99 (full-length P. alba IspS with N-terminal histidine-tag). MD08-99 was purified and the histidine-tag was removed. The same three initial crystallization screens were performed as for MBP-kudzu. The Hampton Research Crystal Screen and Qiagen JCSG+Suite were each performed at multiple protein concentrations. Small needle-like crystals were observed in some Hampton Research Crystal Screen conditions. Further attempts to improve the crystals involved co-crystallization with the IspS inhibitor sodium ibandronate (Sigma-Aldrich, St Louis, Mo.). Taken together, an additional 288 crystallization conditions were attempted with variations of pH, concentration, and crystallization reagents. The nine best crystals were then prepared for data collection and tested in-house on a Rigaku RU200 rotating anode generator and R-AXIS IV++, and they either did not diffract x-rays or were salt crystals.

The first nineteen N-terminal residues of P. alba IspS were removed to produce construct MD08-100. This construct had the N-terminal histidine-tag removed after purification. In house crystallization screens were performed using the Hampton Research Crystal Screen and Qiagen JCS G+Suite, each with multiple protein concentrations. Initial crystal hits included hexagonal plates that diffracted to 16 Å resolution, and small rods that diffracted to 5 Å resolution using the in-house x-ray generator. In an attempt to improve the crystals, MD08-100 was co-crystallized with either sodium ibandronate or sodium pyrophosphate (Sigma-Aldrich, St Louis, Mo.), both of which are inhibitors of the IspS activity. Neither inhibitor resulted in improved crystals or improved diffraction. An additional 168 crystallization conditions were attempted with variations of pH, concentration, and crystallization reagents. The twenty-one most promising MD08-100 crystals were screened for diffraction, with the best resolution obtained being 5 Å.

Full-length, untagged P. alba IspS (strain RM11608-2) from a fermentation run was purified. An initial screen was set up using the Hampton Research Crystal Screen, and crystals were observed in four different conditions. All four crystals were tested for diffraction in-house, with three being salt crystals and one not diffracting.

A truncated P. alba IspS construct featuring two additional residues before the twin-arginine motif was generated (MD09-167). This construct contains a C-terminal histidine-tag, and crystallization experiments were set up with the tag either cleaved or not cleaved, at varying protein concentrations, and with or without sodium pyrophosphate. Initial crystallization screens were done as per MBP-kudzu. Crystals from this construct were observed in numerous conditions; optimization included 528 variations of pH, precipitating agents, concentrations, and inhibitors. From the optimization experiments, fifteen different MD09-167 crystals were screened in-house for diffraction. In an effort to improve the resolution, various crystal freezing conditions were tested, with the effect of improving the diffraction limits from 10 Å to 6.5 Å.

A new construct containing P. tricharpa IspS was generated, which contains both an N-terminal histidine-tag and an N-terminal truncation (MD08-104). Purified MD08-104 with cleaved histidine-tag was surveyed using the Hampton Research Crystal Screen and the Qiagen JCSG+suite. This construct generated heavier precipitate than the P. alba IspS constructs. Very small needles were observed, with none of the crystals being suitable for diffraction.

Another construct composed of IspS from P. tremuloides was generated with an N-terminal histidine-tag and an N-terminal truncation (MD08-102; SEQ ID NO:11). Purified MD08-102 with and without cleaved histidine-tag was set up using the Hampton Research Crystal Screen and the Qiagen JCSG+Suite at varying protein concentrations. Rod and plate-like crystals were observed in some conditions and an additional 120 experiments were performed to improve the crystals by varying pH, concentration, and crystallization reagents. From the optimization experiments, ten crystals were tested in-house, with the initial best diffraction reaching 5 Å. Upon further modification of the freezing conditions of the crystals, a crystal was found that diffracted to 3.3 Å from the uncleaved histidine-tagged protein. This crystal was grown by mixing 2 μL of protein (10 mg/ml, with 30 mM MgCl₂) with 2 μL of precipitant solution [10% (wt/vol) polyethylene glycol 8000, 0.1 M HEPES, pH 7.5, 8% ethylene glycol] and equilibrated against 500 μL of precipitant. A cluster of rod-shaped crystals appeared after three weeks. The crystals belong to the tetragonal space group P43212, and have unit cell dimensions a=154.2, b=154.2, c=142.7.

In-house x-ray diffraction data were collected under a nitrogen stream at 100 K using a Rigaku RU200 generator and R-AXIS IV++ detector. Before flash-freezing the crystal in liquid nitrogen, it was cryoprotected by swiping it through a solution containing 10% (wt/vol) polyethylene glycol 8000, 0.1 M HEPES, pH 7.5, and 25% ethylene glycol. Data were integrated using Mosflm (Leslie, A. (1998) J. of Appl. Crystallography 30, 1036-1040) and scaled using SCALA (Collaborative Computational Project, N. (1994) Acta Crystallographica Section D 50, 760-763). The data were then phased by molecular replacement using MrBUMP (Keegan, R. M., and Winn, M. D. (2007) Acta Crystallographica Section D 63, 447-457; Vagin, A., and Teplyakov, A. (1997) J. of Appl. Crystallography 30, 1022-1025), with a monomer of limonene synthase (Protein Data Bank ID 2ONH) (Berman, H., et al. (2007) Nucl. Acids Res. 35, D301-303) as the starting model. The crystal contains one dimer in the asymmetric unit with a solvent content of 66%.

A 3.05 Å data set from the same crystal was then collected using beamline 11-1 of the Stanford Synchrotron Radiation Laboratory. These data were also processed using Mosflm and SCALA. Data collection and refinement statistics are given in Table 3-1.

Refinement with Refmac5 (Collaborative Computational Project, N. (1994) Acta Crystallographica Section D 50, 760-763) was used with iterative manual rebuilding steps using the visualization program Coot (Emsley, P., and Cowtan, K. (2004) Acta Crystallographica Section D 60, 2126-2132). During refinement, the geometry of the protein was checked using Molprobity (Davis, I. W., et al. (2007) Nucl. Acids Res., gkm216).

The fold of P. tremuloides IspS is similar to bornyl diphosphate synthase (Whittington, D. A., et al. (2002) Proc. Natl. Acad. Sci. USA 99, 15375-15380), limonene synthase (Hyatt, D. C., et al. (2007) Proc. Natl. Acad. Sci. USA 104, 5360-5365), and tobacco 5-epi-aristolochene synthase (Starks, C. M., et al. (1997) Science 277, 1815-1820). The structure consists of two helical domains, a C-terminal domain containing the active site and N-terminal domain with unknown function (FIGS. 30 and 31). Coordinates are provided in Table 3-7.

TABLE 3-1 Data Collection and Refinement Statistics Data Collection Space Group P4₃2₁2 Cell dimensions A, b, c (Å) 154.2, 154.2, 142.7 α, β, γ, (°) 90.0, 90.0, 90.0 Resolution (Å) 37.8-3.05 R_(merge)   16.4 (72.9)^(a) <I/σI> 10.3 (2.6)  Completeness (%) 99.8 (100)  Redundancy 7.3 (7.4) Refinement Resolution (Å) 37.8-3.05 No. measured reflections 248741 No. Unique reflections 34201 R_(work) 21.1 R_(free) 27.1 rmsd bonds, (Å) 0.011 rmsd angles, (°) 1.28 No. of Atoms Protein, ions^(b) 8331 Water 18 Flexible Loops

The unique and unexpected discovery coming from the determination of the three-dimensional structure of isoprene synthase is that several crucial loops forming the active site are flexible. The discovery can be immediately seen when the known structure of other terpene synthases are compared with the structure of isoprene synthase (FIG. 32). Overall, the structures are highly conserved in the conformation of secondary structure and connectivity loops. (In this example of the P. tremuloides IspS from construct P.tremTRC-pET200, the numbering convention is such that the first number of the complete sequence containing the tag is −35, with the first residue of IspS being 1.) However, three segments, forming a considerable portion of the substrate binding pocket, notably the truncated N-terminus, along with two loops comprised of residues 438-453 (Loop I) and residues 512-527 (Loop II) are seen to diverge (FIGS. 33 to 36). This has been attributed to the absence of substrate complexed with the enzyme in our structure determination.

In comparing the enzyme with BdpS, for example, we find that the loops corresponding to residues 498-513 and 573-587 are composed of the same number of residues and have a homologous, but not identical amino sequence in these regions. We expect that the related terpene synthases will be found to display similar flexibility in the segments as these structures become more thoroughly studied. The residues in terpene synthases corresponding to these variable loop regions are enumerated in Table 3-2.

TABLE 3-2 Residues corresponding to variable loops in terpene synthases. P. tremuloides IspS LS BdpS TEAS N-term I Met 1 Met 57 Ile 54 Val 14 Arg 2 Arg 58 Arg 55 Arg 15 Arg 3 Arg 59 Arg 56 Pro 16 Ser 4 Ser 60 Ser 57 Val 17 Ala 5 Gly 61 Gly 58 Ala 18 Asn 6 Asn 62 Asn 59 Asp 19 Tyr 7 Tyr 63 Tyr 60 Phe 20 Glu 8 Asn 64 Gln 61 Ser 21 Pro 9 Pro 65 Pro 62 Pro 22 Asn 10 Ser 66 Ala 63 Ser 23 Ser 11 Arg 67 Leu 64 Leu 24 Trp 12 Trp 68 Trp 65 Trp 25 Asp 13 Asp 69 Asp 66 Gly 26 Tyr 14 Val 70 Ser 67 Asp 27 Asp 15 Asn 71 Asn 68 Gln 28 Tyr 16 Phe 72 Tyr 69 Phe 29 N-term II Leu 17 Ile 73 Ile 70 Leu 30 Leu 18 Gln 74 Gln 71 Ser 31 Ser 19 Ser 75 Ser 72 Phe 32 Ser 20 Leu 76 Leu 73 Ser 34 Asp 21 Leu 77 Asn 74 Ile 35 Thr 22 Ser 78 Thr 75 Asp 36 Asp 23 Asp 79 Pro 76 Asn 37 Glu 24 Tyr 80 Tyr 77 Gln 38 Ser 25 Lys 81 Thr 78 Val 39 Ile 26 Glu 82 Glu 79 Ala 40 Glu 27 Asp 83 Glu 80 Glu 41 Val 28 Lys 84 Arg 81 Lys 42 Loop I Leu 438 Leu 498 Leu 498 Thr 446 Ala 439 Gly 499 Gly 499 Ala 447 Ser 440 Thr 500 Thr 500 The 448 Ala 441 Ser 501 Ser 502 Tyr 449 Ser 442 Val 502 Tyr 503 Glu 450 Ala 443 Glu 503 Phe 504 Val 451 Glu 444 Glu 504 Glu 505 Glu 452 Ile 445 Val 505 Leu 506 Lys 453 Ala 446 Ser 506 Ala 507 Ser 454 Arg 447 Arg 507 Arg 508 Arg 455 Gly 448 Gly 508 Gly 509 Gly 456 Glu 449 Asp 509 Asp 510 Gln 457 Thr 450 Val 510 Val 511 Ile 458 Ala 451 Pro 511 Pro 512 Ala 459 Asn 452 Lys 512 Lys 513 Thr 460 Ser 453 Ser 513 Thr 514 Gly 461 Loop II Tyr 512 Tyr 576 Tyr 573 Tyr 520 Ile 521 His 513 His 577 Leu 574 His 522 Asn 514 Asn 578 His 575 Asn 523 Gly 515 Gly 579 Gly 576 Leu 524 Asp 516 Asp 580 Asp 577 Asp 525 Ala 517 Gly 581 Gly 578 Gly 526 His 518 His 582 Phe 579 Tyr 527 Thr 519 Gly 583 Gly 580 The 528 Ser 520 Thr 584 Val 581 His 529 Pro 521 Gln 585 Gln 582 Pro 530 Asp 522 His 585 His 583 Glu 531 Glu 523 Pro 586 Ser 584 Lys 532 Leu 524 Ile 587 Lys 585 Val 533 Thr 525 Ile 588 Thr 586 Lue 534 Arg 526 His 589 Tyr 587 Lys 535

This important finding can be exploited for the engineering of improved isoprene synthase in a straightforward manner. It would be desirable to exploit the flexibility to enhance enzyme performance by making substitutions in the amino aids forming these segments to facilitate the transitions the enzyme must undergo in the steps of binding substrate and allowing rearrangement of substrate in different kinetic steps that are postulated to occur during enzymatic de-phosphorylation and for electron transfer to convert DMAPP to isoprene.

The structure provides the new insight that these loops can be present in at least two conformations: the “open” form in the absence of substrate, as we have see in the uncomplexed structure of the isoprene synthase, and a “closed,” or active form when the substrate is bound. It would therefore also be beneficial to modify residues coming in contact with the loops in the active form as described in Table 3-3.

TABLE 3-3 Residues coming within 5 angstroms of flexible elements P trem IspS 1N1B 2ONG 5EAS^(e) N-term L17, L18, S19, S20, 70I, 71Q, 72S, 73L, I73, Q74, S75, L76, L30, S31, F32, S33, neighbors S239, R243, F253, 298S, 302S, 312F, F299, R303, F313, S248, K252, Y262, A254, R255, D256, 313V, 314R, 315D, A314, R315, A316, A263, R264, D265, R257, I259, E260, 316R, 318V, 319E, R317, V319, E320, R266, V268, E269, D293, Y295, D296, 352D, 354Y, 355D, D353, Y355, D356, D302, F304, D305, V297, Y298, G299, 356V, 357Y, 358G, V357, Y358, G359, A306, Y307, G308, T300, E303, Y325, 359T, 362E, 384Y, T360, E363, Y385, T309, E312, Y334, L374, Y375, elements 433Y, 434H, elements F434, Y435, elements F383, I384, elements of of loop I, elements of of loop I, elements of of loop I, elements of loop I, elements of loop loop II, V529, L530, loop II, 589I, 590A, loop II, M590, T591, II, I538, I538, V543 T534 594F F595 Loop I Elements of N-term, Elements of N-term, Elements of N-term, Elements of N-term, neighbors D293, Y295, V297, 352D, 354Y, 356V, D353, Y355, V357, D304, F304, A306, E370, A371, W373, 429E, 430A, 432W, E430, A431, W433, E379, S380, W382, L374, S378, T379, 433Y, 437Y, 438T, F434, H438, K439, F383, Y387, T388, P380, F382, Y385, 439P, 441L, 444Y, P440, L442, Y445, P389, V391, Y394, F386, R433, L434 445L, 493R, 494L, L446, R493, L494, L395, R441, V442, C435, N436, D437, 495P, 496D, 497D, A495, D496, D497, I443, D444, D445, V454, S455, C456, 514I, 515Q, 516C, L514, Q515, C516, I462, E463, C464, Y457, M458, T469, 517Y, 518M, 529V, Y517, M518, R529, C465, M466, M477, V472, I476, Y512, 532V, 536I, 572Y, V532, I536, Y573, F480, A484, Y520, elements of loop II elements of loop II elements of loop II elements of loop II Loop II Elements of N- Elements of N- Elements of N- Elements of N- neighbors terminus, E187, L188, terminus, 246D, 247L, terminus, D247, I248, terminus, E195, Q196, R255, R257, F270, 314R, 316R, 329E, R315, R317, E330, R264, R266, F279, E271, Q273, Y274, 330S, 332F, 333W, P331, Q333, H334, E280, Q282, Y283, F285, V288, A439, 344I, 348I, 499G, N345, I347, G499, I294, I297, A447, S440, S442, S508, 500T, 503Y, 568A, T500, V502, A569, T448, E450, V516, H509, C510, T511, 569Q, 570F, 571I, Q570, L571, M572, E517, V518, T519, Y512, R528, V529, 572Y, 588H, 589I, Y573, Q589, M590, Y520, H537, I538, L530, S531, V532 590A, 591G, 592L T591, R592, T593 I539, N540, L541 Selection of Sites for Improvement of Plant Isoprene Synthase

The isoprene synthases of plants were expected to be homologous to the terpene synthases. The three-dimensional structures of three homologous terpene synthases have been determined: Salvia officinalis bornyl diphosphate synthase (BdpS; pdb entry 1N1B), Mentha spicata limonene synthase (LS; pdb entry 2ONG), and tobacco 5-epi-aristolochene synthase (TEAS; pdb entry SEAS). These enzymes share only 33% homology but their tertiary structure is conserved. Sequence identity is shown in Table 3-4, and structural homology between the structures is shown in Table 3-5. In addition, the structures of intermediate complexes with all three related enzymes have shown that not only tertiary folding, but also detailed interactions in the active sites of these enzymes are highly conserved.

TABLE 3-4 Percent Identity of Terpene Cyclases. P trem IspS 1N1B 2ONG 5EAS^(e) P alba IspS^(a) 98.6 40.7 41.3 33.2 P trem IspS^(b) 41.0 41.4 33.2 1N1B^(c) 51.4 33.8 2ONG^(d) 33.3 ^(a) Polar alba isoprene synthase ^(b) Polar tremuloides isoprene synthase ^(c)bornyl diphosphate synthase ^(d)limonene synthase ^(e)5-epi-aristolochene synthase

TABLE 3-5 Structural Alignment of Terpene Synthases. 1N1B^(b) 2ONG^(c) 5EAS^(d) P trem IspS^(a) 1.40 (465)^(e) 1.29 (468) 1.62 (458) 1N1B 1.27 (520) 1.97 (476) 2ONG 1.83 (477) ^(a) Polar tremuloides isoprene synthase ^(b)bornyl diphosphate synthase ^(c)limonene synthase ^(d)5-epi-aristolochene synthase ^(e)Root mean square deviation in Å for Cα atoms, with the number of aligned residues in parenthesis

In this example of the P. tremuloides IspS from construct P.tremTRC-pET200, the numbering convention is such that the first number of the complete sequence containing the tag is −35, with the first residue of IspS being 1.

A comparison of the active site from the structure of BdpS and the structure of IspS indicates that the active site involved in metal ion binding and phosphate recognition is conserved. In particular, Arg 255, Asp 292, Asp 296, Glu 370, Arg 433 and Asn 436 of P. tremuloides IspS were observed to overlap equivalent residues in BdpS. The positioning of an intermediate of the BdpS was also compared with the IspS structure. Based on this it was possible to identify the analogous binding region and the approach direction that dimethylallyl pyrophosphate would require in order to bind and react with the IspS enzyme.

Based on the structure of IspS, sites in the IspS were identified as candidates for mutagenesis to produce variant IspS enzymes with improved performance. Briefly, sites were selected in the IspS that might alter the interaction of the metal binding, diphosphate recognition, DMAPP chain binding and/or the approach to the active site.

I. Diphosphate/Metal Binding Sites

The side chains of amino acid residues in the IspS that are found in proximity to the metal and diphosphate binding side chains were identified. These residues include Asp 293, Tyr 385, Ser 392, and Asp 437 of P. tremuloides IspS. Engineering of these sites may result in increased enzyme activity.

II. Substrate Access Loops

The substrate access loops of IspS are in regions that deviate from the BdpS structure. In the BdpS structure the residues create a cover over the active site. It is likely that upon substrate binding the structure of IspS will form a similar structure. As such the residues in these loops, including residues 440-453 and 512-524, may be in a position to alter the activity of the IspS. In the P. tremuloides IspS enzyme, residues 440-453 have the sequence SASAEIARGETANS (SEQ ID NO:40) and residues 512-526 have the sequence YHNGDAHTSPDEL (SEQ ID NO:41).

III. Isoprenyl Binding Site

The complex of BdpS and the product of the reaction, bornyl diphosphate (PDB entry 1N24), was used to identify residues in the IspS structure that with protein engineering may be used modulate substrate specificity and/or reaction rate (altered on and off rates of substrate and product). These residues include Ser 261, Trp 264, Phe 285, Thr 289, Ser 393, Ser 394, Phe 432, and Try 512 P. tremuloides IspS.

TABLE 3-6 Candidate Mutagenesis Sites P. tremuloides IspS DPP/Metal Binding Sites Asp 293 Tyr 385 Ser 392 Asp 437 Substrate Access Loop I Ser 440 Ala 441 Ser 442 Ala 443 Glu 444 Ile 445 Ala 446 Arg 447 Gly 448 Glu 449 Thr 450 Ala 451 Asn 452 Ser 453 Substate Access Loop II Tyr 512 His 513 Asn 514 Gly 515 Asp 516 Ala 517 His 518 Thr 519 Ser 520 Pro 521 Asp 522 Glu 523 Leu 524 Isoprenyl Binding Site Ser 261 Trp 264 Phe 285 Thr 289 Ser 393 Ser 394 Phe 432 Tyr 512

TABLE 3-7 Coordinates of P. tremuloides IspS HEADER --- XX-XXX-XX xxxx COMPND — REMARK 3 REMARK 3 REFINEMENT. REMARK 3  PROGRAM : REFMAC 5.5.0088 REMARK 3 AUTHORS : MURSHUDOV, VAGIN, DODSON REMARK 3 REMARK 3  REFINEMENT TARGET: MAXIMUM LIKELIHOOD REMARK 3 REMARK 3 DATA USED IN REFINEMENT. REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS): 3.05 REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS): 110.17 REMARK 3 DATA CUTOFF (SIGMA(F)): NONE REMARK 3 COMPLETENESS FOR RANGE (%): 99.67 REMARK 3 NUMBER OF REFLECTIONS : 32446 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3 CROSS-VALIDATION METHOD: THROUGHOUT REMARK 3 FREE R VALUE TEST SET SELECTION: RANDOM REMARK 3 R VALUE (WORKING + TEST SET): .21396 REMARK 3 R VALUE (WORKING SET) : .21092 REMARK 3 FREE R VALUE: .27112 REMARK 3 FREE R VALUE TEST SET SIZE (%): 5.1 REMARK 3 FREE R VALUE TEST SET COUNT : 1727 REMARK 3 REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN. REMARK 3 TOTAL NUMBER OF BINS USED : 20 REMARK 3 BIN RESOLUTION RANGE HIGH : 3.050 REMARK 3 BIN RESOLUTION RANGE LOW : 3.129 REMARK 3 REFLECTION IN BIN (WORKING SET): 2359 REMARK 3 BIN COMPLETENESS (WORKING + TEST) (%): 100.00 REMARK 3 BIN R VALUE (WORKING SET): .288 REMARK 3 BIN FREE R VALUE SET COUNT : 127 REMARK 3 BIN FREE R VALUE : .352 REMARK 3 REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT. REMARK 3 ALL ATOMS : 8349 REMARK 3 REMARK 3 B VALUES. REMARK 3 FROM WILSON PLOT (A**2): NULL REMARK 3 MEAN B VALUE (OVERALL, A**2): 24.592 REMARK 3 OVERALL ANISOTROPIC B VALUE. REMARK 3  B11 (A**2): .41 REMARK 3  B22 (A**2): .41 REMARK 3  B33 (A**2): −.81 REMARK 3  B12 (A**2): .00 REMARK 3  B13 (A**2): .00 REMARK 3  B23 (A**2): .00 REMARK 3 REMARK 3 ESTIMATED OVERALL COORDINATE ERROR. REMARK 3 ESU BASED ON R VALUE (A): NULL REMARK 3 ESU BASED ON FREE R VALUE (A): .427 REMARK 3 ESU BASED ON MAXIMUM LIKELIHOOD (A): .327 REMARK 3 ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 39.836 REMARK 3 REMARK 3 CORRELATION COEFFICIENTS. REMARK 3 CORRELATION COEFFICIENT FO-FC : .916 REMARK 3 CORRELATION COEFFICIENT FO-FC FREE : .868 REMARK 3 REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES COUNT RMS WEIGHT REMARK 3 BOND LENGTHS REFINED ATOMS (A): 8495; .011;.022 REMARK 3 BOND LENGTHS OTHERS (A): 5804; .001; .020 REMARK 3 BOND ANGLES REFINED ATOMS (DEGREES): 11476; 1.279; 1.953 REMARK 3 BOND ANGLES OTHERS (DEGREES): 14093; .882; 3.000 REMARK 3 TORSION ANGLES, PERIOD 1 (DEGREES): 1020; 7.002; 5.000 REMARK 3 TORSION ANGLES, PERIOD 2 (DEGREES): 435; 35.412; 24.299 REMARK 3 TORSION ANGLES, PERIOD 3 (DEGREES): 1525; 18.250; 15.000 REMARK 3 TORSION ANGLES, PERIOD 4 (DEGREES): 58; 16.811; 15.000 REMARK 3 CHIRAL-CENTER RESTRAINTS (A**3): 1266; .070; .200 REMARK 3 GENERAL PLANES REFINED ATOMS (A): 9416; .005; .020 REMARK 3 GENERAL PLANES OTHERS (A): 1780; .001; .020 REMARK 3 REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT REMARK 3 MAIN-CHAIN BOND REFINED ATOMS (A**2): 5104; .514; 1.500 REMARK 3 MAIN-CHAIN BOND OTHER ATOMS (A**2): 2068; .059; 1.500 REMARK 3 MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 8204; 1.000; 2.000 REMARK 3 SIDE-CHAIN BOND REFINED ATOMS (A**2): 3391; 1.218; 3.000 REMARK 3 SIDE-CHAIN ANGLE REFINED ATOMS (A**2): 3272; 2.157; 4.500 REMARK 3 REMARK 3 NCS RESTRAINTS STATISTICS REMARK 3 NUMBER OF DIFFERENT NCS GROUPS: 1 REMARK 3 REMARK 3 NCS GROUP NUMBER : 1 REMARK 3  CHAIN NAMES: A B REMARK 3  NUMBER OF COMPONENTS NCS GROUP: 1 REMARK 3  COMPONENT C SSSEQI TO C SSSEQI CODE REMARK 3  1 A 17 A 541 6 REMARK 3  1 B 17 B 541 6 REMARK 3  GROUP CHAIN COUNT RMS WEIGHT REMARK 3 LOOSE POSITIONAL 1 1 (A): 7038; .37; 5.00 REMARK 3 LOOSE THERMAL 1 1 (A**2): 7038; 1.09; 10.00 REMARK 3 REMARK 3 TWIN DETAILS REMARK 3 NUMBER OF TWIN DOMAINS: NULL REMARK 3 REMARK 3 REMARK 3 TLS DETAILS REMARK 3 NUMBER OF TLS GROUPS : 8 REMARK 3 ATOM RECORD CONTAINS RESIDUAL B FACTORS ONLY REMARK 3 REMARK 3 TLS GROUP: 1 REMARK 3  NUMBER OF COMPONENTS GROUP: 1 REMARK 3  COMPONENTS C SSSEQI TO C SSSEQI REMARK 3  RESIDUE RANGE: A 17 A 219 REMARK 3  ORIGIN FOR THE GROUP (A): −64.7667 37.6643 −.0896 REMARK 3  T TENSOR REMARK 3  T11: .0648 T22: .0357 REMARK 3  T33: .0787 T12: .0200 REMARK 3  T13: .0129 T23: −.0089 REMARK 3  L TENSOR REMARK 3  L11: 3.7204 L22: 1.5111 REMARK 3  L33: 2.6701 L12: .5715 REMARK 3  L13:  .6692 L23: −.9699 REMARK 3  S TENSOR REMARK 3  S11: .0562 S12: .0478 S13: −.1976 REMARK 3  S21: −.1702 S22: −.0055 S23: .1376 REMARK 3  S31: .0900 S32: −.2188 S33: −.0507 REMARK 3 REMARK 3 TLS GROUP: 2 REMARK 3  NUMBER OF COMPONENTS GROUP: 1 REMARK 3  COMPONENTS C SSSEQI TO C SSSEQI REMARK 3  RESIDUE RANGE: A 220 A 287 REMARK 3  ORIGIN FOR THE GROUP (A): −59.5787 8.4529 −.7693 REMARK 3  T TENSOR REMARK 3  T11: .1615 T22: .0645 REMARK 3  T33: .1539 T12: −.0314 REMARK 3  T13: −.0461 T23: .0198 REMARK 3  L TENSOR REMARK 3  L11: 2.4192 L22: 4.6709 REMARK 3  L33: .7709 L12: −3.2943 REMARK 3  L13: −.1814 L23: −.0705 REMARK 3  S TENSOR REMARK 3  S11: .0055 S12: −.0699 S13: −.2073 REMARK 3  S21: −.1805 S22: .0996 S23: .3781 REMARK 3  S31: .2596 S32: .0887 S33: −.1051 REMARK 3 REMARK 3 TLS GROUP: 3 REMARK 3  NUMBER OF COMPONENTS GROUP: 1 REMARK 3  COMPONENTS C SSSEQI TO C SSSEQI REMARK 3  RESIDUE RANGE: A 288 A 374 REMARK 3  ORIGIN FOR THE GROUP (A): −40.1866 1.6932 .5805 REMARK 3  T TENSOR REMARK 3  T11: .1149 T22: .1003 REMARK 3  T33: .1629 T12: .0153 REMARK 3  T13: .0224 T23: .0164 REMARK 3  L TENSOR REMARK 3  L11: .2271 L22: .7399 REMARK 3  L33: 4.8529 L12: .3413 REMARK 3  L13: .4755 L23: −.1746 REMARK 3  S TENSOR REMARK 3  S11: −.0449 S12: −.0288 S13: −.1131 REMARK 3  S21: −.1346 S22: −.0665 S23: −.2749 REMARK 3  S31: −.0040 S32: .1558 S33: 1114 REMARK 3 REMARK 3 TLS GROUP: 4 REMARK 3  NUMBER OF COMPONENTS GROUP: 1 REMARK 3  COMPONENTS C SSSEQI TO C SSSEQI REMARK 3  RESIDUE RANGE: A 375 A 541 REMARK 3  ORIGIN FOR THE GROUP (A): −47.2220 21.5399 6.9217 REMARK 3  T TENSOR REMARK 3  T11: .1551 T22: .1194 REMARK 3  T33: .1485 T12: −.0666 REMARK 3  T13: .0275 T23: .0272 REMARK 3  L TENSOR REMARK 3  L11: 2.2352 L22: 2.1698 REMARK 3  L33: 2.3370 L12: −.4501 REMARK 3  L13: 2.2662 L23: −.1852 REMARK 3  S TENSOR REMARK 3  S11: .0233 S12: −.3041 S13: −.0323 REMARK 3  S21: .3375 S22: .0236 S23: .0121 REMARK 3  S31: .0592 S32: −.2979 S33: −.0469 REMARK 3 REMARK 3 TLS GROUP: 5 REMARK 3  NUMBER OF COMPONENTS GROUP: 1 REMARK 3  COMPONENTS C SSSEQI TO C SSSEQI REMARK 3  RESIDUE RANGE: B 17 B 219 REMARK 3  ORIGIN FOR THE GROUP (A): −73.9834 −39.9016 −18.5783 REMARK 3  T TENSOR REMARK 3  T11: .0658 T22: .1153 REMARK 3  T33: .1251 T12: −.0621 REMARK 3  T13: −.0164 T23: −.0098 REMARK 3  L TENSOR REMARK 3  L11: 4.6230 L22: 1.7260 REMARK 3  L33: 3.8816 L12: −.4202 REMARK 3  L13: −1.8646 L23: −.9046 REMARK 3  S TENSOR REMARK 3  S11: −.0685 S12: .0375 S13: −.0003 REMARK 3  S21: .1931 S22: .0510 S23: −.0097 REMARK 3  S31: .0317 S32: −.2047 S33: .0175 REMARK 3 REMARK 3 TLS GROUP: 6 REMARK 3  NUMBER OF COMPONENTS GROUP: 1 REMARK 3  COMPONENTS C SSSEQI TO C SSSEQI REMARK 3  RESIDUE RANGE: B 220 B 287 REMARK 3  ORIGIN FOR THE GROUP (A): −62.1586 −12.7634 −18.1912 REMARK 3  T TENSOR REMARK 3  T11: .1825 T22: .0804 REMARK 3  T33: .1512 T12: .0549 REMARK 3  T13: .0773 T23: .0208 REMARK 3  L TENSOR REMARK 3  L11: 5.4421 L22: 4.0606 REMARK 3  L33: 1.5369 L12: 4.6706 REMARK 3  L13: −2.0058 L23: −1.5537 REMARK 3  S TENSOR REMARK 3  S11: .1622 S12: .0431 S13: .3257 REMARK 3  S21: .1755 S22: .0292 S23: .2977 REMARK 3  S31: −.1910 S32: −.0506 S33: −.1914 REMARK 3 REMARK 3 TLS GROUP: 7 REMARK 3  NUMBER OF COMPONENTS GROUP: 1 REMARK 3  COMPONENTS C SSSEQI TO C SSSEQI REMARK 3  RESIDUE RANGE: B 288 B 374 REMARK 3  ORIGIN FOR THE GROUP (A): −41.6930 −10.8250 −19.6636 REMARK 3  T TENSOR REMARK 3  T11: .1424 T22: .0604 REMARK 3  T33: .1153 T12: .0184 REMARK 3  T13: .0146 T23: .0276 REMARK 3  L TENSOR REMARK 3  L11: .6426 L22: .8163 REMARK 3  L33: 2.3437 L12: −.1831 REMARK 3  L13: −.5246 L23: .4917 REMARK 3  S TENSOR REMARK 3  S11: .0592 S12: −.0206 S13: .0071 REMARK 3  S21: .0906 S22: −.0229 S23: −.1585 REMARK 3  S31: −.0355 S32 .0262 S33: −.0363 REMARK 3 REMARK 3 TLS GROUP: 8 REMARK 3  NUMBER OF COMPONENTS GROUP: 1 REMARK 3  COMPONENTS C SSSEQI TO C SSSEQI REMARK 3  RESIDUE RANGE: B 375 B 541 REMARK 3  ORIGIN FOR THE GROUP (A): −53.4886 −28.3212 −26.0670 REMARK 3  T TENSOR REMARK 3  T11:.1107 T22: .1220 REMARK 3  T33: .1514 T12 .0692 REMARK 3  T13: −.0073 T23: .0518 REMARK 3  L TENSOR REMARK 3  L11: 2.6766 L22: 1.8433 REMARK 3  L33: 2.6389 L12: .1130 REMARK 3  L13: −2.4696 L23: .6986 REMARK 3  S TENSOR REMARK 3  S11: .1115 S12: .3882 S13: .0569 REMARK 3  S21: −.0725 S22: −.0724 S23: .1450 REMARK 3  S31: −.1453 S32: −.4044 S33: −.0392 REMARK 3 REMARK 3 REMARK 3 BULK SOLVENT MODELLING. REMARK 3 METHOD USED: MASK REMARK 3 PARAMETERS FOR MASK CALCULATION REMARK 3 VDW PROBE RADIUS: 1.40 REMARK 3 ION PROBE RADIUS: .80 REMARK 3 SHRINKAGE RADIUS: .80 REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: REMARK 3 HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS REMARK 3 U VALUES: RESIDUAL ONLY REMARK 3 CISPEP 1 ALA A 446 ARG A 447 .00 CISPEP 2 GLY A 515 ASP A 516 .00 CISPEP 3 THR B 22 ASP B 23 .00 CISPEP 4 ALA B 446 ARG B 447 .00 CISPEP 5 GLY B 515 ASP B 516 .00 CRYST1 155.800 155.800 143.690 90.00 90.00 90.00 P 43 21 2 SCALE1 .006418 .000000 .000000 .00000 SCALE2 .000000 .006418 .000000 .00000 SCALE3 .000000 .000000 .006959 .00000 ATOM 1 N LEU A 17 −63.930 24.416 −19.202 1.00 30.90 N ATOM 2 CA LEU A 17 −64.132 23.019 −19.731 1.00 31.43 C ATOM 4 CB LEU A 17 −63.308 22.800 −21.021 1.00 31.35 C ATOM 7 CG LEU A 17 −64.002 23.016 −22.386 1.00 31.95 C ATOM 9 CD1 LEU A 17 −62.989 23.068 −23.550 1.00 31.88 C ATOM 13 CD2 LEU A 17 −65.052 21.915 −22.676 1.00 31.95 C ATOM 17 C LEU A 17 −63.783 21.952 −18.660 1.00 31.39 C ATOM 18 O LEU A 17 −63.142 22.291 −17.651 1.00 31.61 O ATOM 22 N LEU A 18 −64.216 20.693 −18.877 1.00 31.11 N ATOM 23 CA LEU A 18 −63.986 19.529 −17.957 1.00 30.78 C ATOM 25 CB LEU A 18 −62.503 19.072 −17.935 1.00 30.97 C ATOM 28 CG LEU A 18 −61.303 19.949 −17.496 1.00 31.10 C ATOM 30 CD1 LEU A 18 −61.406 20.430 −16.064 1.00 30.71 C ATOM 34 CD2 LEU A 18 −59.977 19.173 −17.703 1.00 31.87 C ATOM 38 C LEU A 18 −64.531 19.665 −16.522 1.00 30.38 C ATOM 39 O LEU A 18 −64.837 18.667 −15.883 1.00 29.86 O ATOM 41 N SER A 19 −64.587 20.900 −16.023 1.00 30.45 N ATOM 42 CA SER A 19 −65.335 21.276 −14.815 1.00 30.37 C ATOM 44 CB SER A 19 −64.604 22.417 −14.026 1.00 30.02 C ATOM 47 OG SER A 19 −64.881 23.741 −14.489 1.00 28.00 O ATOM 49 C SER A 19 −66.784 21.654 −15.218 1.00 31.03 C ATOM 50 O SER A 19 −67.666 21.711 −14.367 1.00 30.95 O ATOM 52 N SER A 20 −67.023 21.880 −16.519 1.00 31.85 N ATOM 53 CA SER A 20 −68.355 22.247 −17.051 1.00 32.37 C ATOM 55 CB SER A 20 −68.291 22.507 −18.579 1.00 32.39 C ATOM 58 OG SER A 20 −67.387 23.542 −18.931 1.00 31.77 O ATOM 60 C SER A 20 −69.357 21.124 −16.744 1.00 33.04 C ATOM 61 O SER A 20 −69.076 20.254 −15.922 1.00 33.08 O ATOM 63 N ASP A 21 −70.522 21.136 −17.393 1.00 33.88 N ATOM 64 CA ASP A 21 −71.512 20.069 −17.206 1.00 34.48 C ATOM 66 CB ASP A 21 −72.907 20.655 −17.127 1.00 34.59 C ATOM 69 CG ASP A 21 −73.022 21.661 −16.006 1.00 35.54 C ATOM 70 OD1 ASP A 21 −72.041 21.836 −15.251 1.00 35.31 O ATOM 71 OD2 ASP A 21 −74.082 22.289 −15.870 1.00 38.72 O ATOM 72 C ASP A 21 −71.409 18.975 −18.260 1.00 34.94 C ATOM 73 O ASP A 21 −72.134 18.947 −19.269 1.00 34.58 O ATOM 75 N THR A 22 −70.457 18.086 −17.989 1.00 35.66 N ATOM 76 CA THR A 22 −70.340 16.799 −18.657 1.00 36.27 C ATOM 78 CB THR A 22 −68.895 16.576 −19.168 1.00 36.30 C ATOM 80 OG1 THR A 22 −67.968 17.278 −18.322 1.00 36.04 O ATOM 82 CG2 THR A 22 −68.755 17.088 −20.604 1.00 36.11 C ATOM 86 C THR A 22 −70.792 15.714 −17.648 1.00 36.83 C ATOM 87 O THR A 22 −69.968 15.022 −17.035 1.00 37.05 O ATOM 89 N ASP A 23 −72.121 15.599 −17.494 1.00 37.27 N ATOM 90 CA ASP A 23 −72.790 14.802 −16.441 1.00 37.25 C ATOM 92 CB ASP A 23 −72.962 15.659 −15.167 1.00 37.17 C ATOM 95 CG ASP A 23 −71.625 16.081 −14.549 1.00 37.74 C ATOM 96 OD1 ASP A 23 −70.714 15.241 −14.436 1.00 38.88 O ATOM 97 OD2 ASP A 23 −71.472 17.256 −14.164 1.00 38.91 O ATOM 98 C ASP A 23 −74.172 14.351 −16.956 1.00 37.18 C ATOM 99 O ASP A 23 −75.137 15.112 −16.846 1.00 37.10 O ATOM 101 N GLU A 24 −74.280 13.134 −17.501 1.00 37.23 N ATOM 102 CA GLU A 24 −75.406 12.815 −18.410 1.00 37.58 C ATOM 104 CB GLU A 24 −74.941 13.007 −19.865 1.00 37.77 C ATOM 107 CG GLU A 24 −74.424 14.417 −20.239 1.00 37.98 C ATOM 110 CD GLU A 24 −74.121 14.556 −21.746 1.00 38.35 C ATOM 111 OE1 GLU A 24 −74.284 13.564 −22.503 1.00 38.12 O ATOM 112 OE2 GLU A 24 −73.721 15.661 −22.174 1.00 38.18 O ATOM 113 C GLU A 24 −76.139 11.440 −18.323 1.00 37.79 C ATOM 114 O GLU A 24 −77.323 11.397 −17.960 1.00 37.90 O ATOM 116 N SER A 25 −75.462 10.345 −18.696 1.00 37.92 N ATOM 117 CA SER A 25 −76.140 9.070 −19.048 1.00 38.09 C ATOM 119 CB SER A 25 −75.167 8.076 −19.723 1.00 38.11 C ATOM 122 OG SER A 25 −74.503 7.239 −18.787 1.00 38.02 O ATOM 124 C SER A 25 −76.917 8.374 −17.907 1.00 38.42 C ATOM 125 O SER A 25 −76.635 8.581 −16.724 1.00 38.15 O ATOM 127 N ILE A 26 −77.861 7.511 −18.312 1.00 39.00 N ATOM 128 CA ILE A 26 −78.993 7.042 −17.476 1.00 39.30 C ATOM 130 CB ILE A 26 −78.594 5.965 −16.429 1.00 39.34 C ATOM 132 CG1 ILE A 26 −77.892 4.791 −17.120 1.00 39.37 C ATOM 135 CD1 ILE A 26 −77.766 3.531 −16.253 1.00 39.46 C ATOM 139 CG2 ILE A 26 −79.836 5.423 −15.714 1.00 39.29 C ATOM 143 C ILE A 26 −79.716 8.260 −16.852 1.00 39.66 C ATOM 144 O ILE A 26 −79.274 8.831 −15.838 1.00 39.49 O ATOM 146 N GLU A 27 −80.837 8.623 −17.486 1.00 39.99 N ATOM 147 CA GLU A 27 −81.450 9.965 −17.383 1.00 40.11 C ATOM 149 CB GLU A 27 −82.395 10.183 −18.587 1.00 40.19 C ATOM 152 CG GLU A 27 −81.632 10.311 −19.904 1.00 40.60 C ATOM 155 CD GLU A 27 −82.528 10.434 −21.116 1.00 41.06 C ATOM 156 OE1 GLU A 27 −83.328 9.502 −21.367 1.00 41.10 O ATOM 157 OE2 GLU A 27 −82.409 11.458 −21.830 1.00 41.36 O ATOM 158 C GLU A 27 −82.144 10.264 −16.042 1.00 40.02 C ATOM 159 O GLU A 27 −81.977 9.518 −15.071 1.00 40.01 O ATOM 161 N VAL A 28 −82.899 11.370 −16.005 1.00 39.84 N ATOM 162 CA VAL A 28 −83.463 11.960 −14.779 1.00 39.65 C ATOM 164 CB VAL A 28 −83.884 10.905 −13.694 1.00 39.78 C ATOM 166 CG1 VAL A 28 −84.472 11.596 −12.456 1.00 39.87 C ATOM 170 CG2 VAL A 28 −84.887 9.880 −14.274 1.00 39.49 C ATOM 174 C VAL A 28 −82.469 12.980 −14.206 1.00 39.46 C ATOM 175 O VAL A 28 −82.798 13.717 −13.270 1.00 39.38 O ATOM 177 N HIS A 29 −81.264 13.025 −14.786 1.00 39.30 N ATOM 178 CA HIS A 29 −80.236 14.006 −14.412 1.00 39.23 C ATOM 180 CB HIS A 29 −78.866 13.344 −14.186 1.00 39.45 C ATOM 183 CG HIS A 29 −78.910 12.139 −13.296 1.00 41.29 C ATOM 184 ND1 HIS A 29 −78.407 12.140 −12.007 1.00 42.51 N ATOM 186 CE1 HIS A 29 −78.585 10.942 −11.472 1.00 43.37 C ATOM 188 NE2 HIS A 29 −79.181 10.164 −12.365 1.00 43.18 N ATOM 190 CD2 HIS A 29 −79.393 10.888 −13.515 1.00 42.55 C ATOM 192 C HIS A 29 −80.090 15.110 −15.464 1.00 38.60 C ATOM 193 O HIS A 29 −79.049 15.774 −15.499 1.00 38.61 O ATOM 195 N LYS A 30 −81.110 15.320 −16.311 1.00 37.87 N ATOM 196 CA LYS A 30 −81.265 16.610 −17.001 1.00 37.22 C ATOM 198 CB LYS A 30 −82.283 16.542 −18.140 1.00 37.09 C ATOM 201 CG LYS A 30 −81.764 15.794 −19.360 1.00 37.00 C ATOM 204 CD LYS A 30 −82.831 15.653 −20.457 1.00 36.89 C ATOM 207 CE LYS A 30 −82.413 14.637 −21.531 1.00 36.48 C ATOM 210 NZ LYS A 30 −83.422 14.458 −22.611 1.00 35.46 N ATOM 214 C LYS A 30 −81.648 17.649 −15.938 1.00 36.88 C ATOM 215 O LYS A 30 −82.516 18.499 −16.136 1.00 36.71 O ATOM 217 N ASP A 31 −80.982 17.506 −14.788 1.00 36.58 N ATOM 218 CA ASP A 31 −80.895 18.476 −13.720 1.00 36.18 C ATOM 220 CB ASP A 31 −80.518 17.751 −12.396 1.00 36.20 C ATOM 223 CG ASP A 31 −79.863 18.669 −11.342 1.00 36.65 C ATOM 224 OD1 ASP A 31 −80.055 19.901 −11.390 1.00 38.17 O ATOM 225 OD2 ASP A 31 −79.147 18.150 −10.449 1.00 35.46 O ATOM 226 C ASP A 31 −79.811 19.426 −14.226 1.00 35.74 C ATOM 227 O ASP A 31 −78.628 19.279 −13.918 1.00 35.44 O ATOM 229 N LYS A 32 −80.220 20.343 −15.096 1.00 35.30 N ATOM 230 CA LYS A 32 −79.360 21.449 −15.507 1.00 34.69 C ATOM 232 CB LYS A 32 −78.698 21.188 −16.849 1.00 34.63 C ATOM 235 CG LYS A 32 −77.699 20.042 −16.765 1.00 34.51 C ATOM 238 CD LYS A 32 −76.953 19.853 −18.078 1.00 34.48 C ATOM 241 CE LYS A 32 −76.859 18.387 −18.503 1.00 33.77 C ATOM 244 NZ LYS A 32 −77.002 18.244 −19.985 1.00 32.92 N ATOM 248 C LYS A 32 −80.162 22.745 −15.459 1.00 34.01 C ATOM 249 O LYS A 32 −80.468 23.380 −16.473 1.00 33.41 O ATOM 251 N ALA A 33 −80.540 23.051 −14.219 1.00 33.21 N ATOM 252 CA ALA A 33 −80.785 24.381 −13.766 1.00 32.60 C ATOM 254 CB ALA A 33 −81.619 24.347 −12.484 1.00 32.28 C ATOM 258 C ALA A 33 −79.411 25.031 −13.524 1.00 32.31 C ATOM 259 O ALA A 33 −79.335 26.081 −12.901 1.00 32.80 O ATOM 261 N LYS A 34 −78.323 24.389 −13.968 1.00 31.70 N ATOM 262 CA LYS A 34 −77.035 25.071 −14.186 1.00 31.12 C ATOM 264 CB LYS A 34 −75.863 24.089 −14.128 1.00 31.23 C ATOM 267 CG LYS A 34 −75.118 24.077 −12.791 1.00 31.76 C ATOM 270 CD LYS A 34 −73.584 24.412 −12.921 1.00 31.49 C ATOM 273 CE LYS A 34 −72.685 23.269 −12.506 1.00 30.50 C ATOM 276 NZ LYS A 34 −72.951 22.090 −13.348 1.00 29.53 N ATOM 280 C LYS A 34 −77.024 25.884 −15.518 1.00 30.50 C ATOM 281 O LYS A 34 −76.977 25.353 −16.625 1.00 29.82 O ATOM 283 N LYS A 35 −76.927 27.191 −15.337 1.00 29.97 N ATOM 284 CA LYS A 35 −77.632 28.233 −16.098 1.00 29.41 C ATOM 286 CB LYS A 35 −78.852 27.704 −16.867 1.00 29.53 C ATOM 289 CG LYS A 35 −80.166 27.594 −16.077 1.00 30.18 C ATOM 292 CD LYS A 35 −81.030 28.858 −16.203 1.00 31.25 C ATOM 295 CE LYS A 35 −82.375 28.721 −15.486 1.00 31.85 C ATOM 298 NZ LYS A 35 −83.298 29.865 −15.783 1.00 31.73 N ATOM 302 C LYS A 35 −78.053 29.277 −15.026 1.00 28.53 C ATOM 303 O LYS A 35 −78.246 30.460 −15.307 1.00 28.53 O ATOM 305 N LEU A 36 −78.225 28.791 −13.796 1.00 27.29 N ATOM 306 CA LEU A 36 −77.998 29.576 −12.594 1.00 26.21 C ATOM 308 CB LEU A 36 −78.088 28.679 −11.364 1.00 25.76 C ATOM 311 CG LEU A 36 −79.468 28.350 −10.832 1.00 24.08 C ATOM 313 CD1 LEU A 36 −79.376 27.233 −9.836 1.00 22.16 C ATOM 317 CD2 LEU A 36 −80.051 29.586 −10.213 1.00 23.45 C ATOM 321 C LEU A 36 −76.587 30.137 −12.665 1.00 25.93 C ATOM 322 O LEU A 36 −76.290 31.221 −12.137 1.00 26.11 O ATOM 324 N GLU A 37 −75.714 29.332 −13.260 1.00 25.24 N ATOM 325 CA GLU A 37 −74.381 29.739 −13.650 1.00 24.85 C ATOM 327 CB GLU A 37 −73.678 28.566 −14.313 1.00 24.74 C ATOM 330 CG GLU A 37 −72.182 28.667 −14.285 1.00 23.93 C ATOM 333 CD GLU A 37 −71.519 27.490 −14.937 1.00 22.32 C ATOM 334 OE1 GLU A 37 −72.203 26.738 −15.657 1.00 20.57 O ATOM 335 OE2 GLU A 37 −70.303 27.322 −14.728 1.00 22.27 O ATOM 336 C GLU A 37 −74.391 30.927 −14.600 1.00 24.69 C ATOM 337 O GLU A 37 −73.666 31.891 −14.389 1.00 24.49 O ATOM 339 N ALA A 38 −75.203 30.850 −15.650 1.00 24.68 N ATOM 340 CA ALA A 38 −75.352 31.960 −16.599 1.00 24.87 C ATOM 342 CB ALA A 38 −76.453 31.656 −17.609 1.00 24.53 C ATOM 346 C ALA A 38 −75.643 33.278 −15.880 1.00 25.08 C ATOM 347 O ALA A 38 −75.009 34.295 −16.135 1.00 25.21 O ATOM 349 N GLU A 39 −76.591 33.228 −14.956 1.00 25.35 N ATOM 350 CA GLU A 39 −77.050 34.400 −14.219 1.00 25.51 C ATOM 352 CB GLU A 39 −78.283 34.014 −13.396 1.00 25.95 C ATOM 355 CG GLU A 39 −79.302 35.119 −13.136 1.00 27.03 C ATOM 358 CD GLU A 39 −80.715 34.557 −12.906 1.00 28.70 C ATOM 359 OE1 GLU A 39 −81.006 33.416 −13.346 1.00 27.40 O ATOM 360 OE2 GLU A 39 −81.540 35.266 −12.289 1.00 31.12 O ATOM 361 C GLU A 39 −75.970 34.966 −13.306 1.00 25.11 C ATOM 362 O GLU A 39 −75.870 36.167 −13.164 1.00 25.28 O ATOM 364 N VAL A 40 −75.182 34.107 −12.672 1.00 24.86 N ATOM 365 CA VAL A 40 −74.079 34.568 −11.824 1.00 24.69 C ATOM 367 CB VAL A 40 −73.511 33.420 −10.952 1.00 24.56 C ATOM 369 CG1 VAL A 40 −72.239 33.857 −10.240 1.00 23.69 C ATOM 373 CG2 VAL A 40 −74.553 32.955 −9.955 1.00 24.68 C ATOM 377 C VAL A 40 −72.971 35.148 −12.698 1.00 24.76 C ATOM 378 O VAL A 40 −72.337 36.139 −12.362 1.00 24.16 O ATOM 380 N ARG A 41 −72.744 34.506 −13.831 1.00 25.25 N ATOM 381 CA ARG A 41 −71.727 34.948 −14.769 1.00 25.66 C ATOM 383 CB ARG A 41 −71.576 33.927 −15.896 1.00 25.88 C ATOM 386 CG ARG A 41 −70.726 34.385 −17.062 1.00 27.04 C ATOM 389 CD ARG A 41 −71.519 35.178 −18.095 1.00 27.90 C ATOM 392 NE ARG A 41 −70.653 35.635 −19.180 1.00 29.20 N ATOM 394 CZ ARG A 41 −70.946 36.615 −20.034 1.00 29.94 C ATOM 395 NH1 ARG A 41 −70.077 36.945 −20.980 1.00 29.86 N ATOM 398 NH2 ARG A 41 −72.096 37.273 −19.957 1.00 30.54 N ATOM 401 C ARG A 41 −72.104 36.301 −15.335 1.00 25.60 C ATOM 402 O ARG A 41 −71.237 37.113 −15.612 1.00 25.77 O ATOM 404 N ARG A 42 −73.400 36.521 −15.537 1.00 25.50 N ATOM 405 CA ARG A 42 −73.900 37.810 −15.979 1.00 25.39 C ATOM 407 CB ARG A 42 −75.389 37.723 −16.313 1.00 25.09 C ATOM 410 CG ARG A 42 −76.077 39.062 −16.445 1.00 23.84 C ATOM 413 CD ARG A 42 −77.459 38.906 −16.980 1.00 22.37 C ATOM 416 NE ARG A 42 −78.448 38.554 −15.965 1.00 21.69 N ATOM 418 CZ ARG A 42 −79.705 38.206 −16.248 1.00 22.99 C ATOM 419 NH1 ARG A 42 −80.122 38.146 −17.517 1.00 24.16 N ATOM 422 NH2 ARG A 42 −80.557 37.900 −15.275 1.00 22.94 N ATOM 425 C ARG A 42 −73.666 38.889 −14.925 1.00 26.00 C ATOM 426 O ARG A 42 −73.173 39.959 −15.244 1.00 26.17 O ATOM 428 N GLU A 43 −74.014 38.621 −13.673 1.00 26.66 N ATOM 429 CA GLU A 43 −73.930 39.662 −12.650 1.00 27.47 C ATOM 431 CB GLU A 43 −74.749 39.304 −11.401 1.00 27.97 C ATOM 434 CG GLU A 43 −76.274 39.266 −11.661 1.00 31.05 C ATOM 437 CD GLU A 43 −76.869 40.636 −12.063 1.00 34.68 C ATOM 438 OE1 GLU A 43 −76.804 41.571 −11.222 1.00 37.63 O ATOM 439 OE2 GLU A 43 −77.398 40.773 −13.205 1.00 34.52 O ATOM 440 C GLU A 43 −72.494 40.035 −12.275 1.00 27.15 C ATOM 441 O GLU A 43 −72.292 41.118 −11.716 1.00 27.49 O ATOM 443 N ILE A 44 −71.517 39.166 −12.588 1.00 26.57 N ATOM 444 CA ILE A 44 −70.090 39.456 −12.334 1.00 25.80 C ATOM 446 CB ILE A 44 −69.206 38.187 −12.187 1.00 25.52 C ATOM 448 CG1 ILE A 44 −69.624 37.320 −11.010 1.00 24.69 C ATOM 451 CD1 ILE A 44 −68.828 36.061 −10.899 1.00 23.08 C ATOM 455 CG2 ILE A 44 −67.790 38.581 −11.916 1.00 25.73 C ATOM 459 C ILE A 44 −69.522 40.286 −13.472 1.00 25.40 C ATOM 460 O ILE A 44 −68.745 41.211 −13.236 1.00 25.26 O ATOM 462 N ASN A 45 −69.912 39.945 −14.700 1.00 25.14 N ATOM 463 CA ASN A 45 −69.480 40.669 −15.906 1.00 25.02 C ATOM 465 CB ASN A 45 −69.696 39.813 −17.151 1.00 24.69 C ATOM 468 CG ASN A 45 −68.662 38.735 −17.302 1.00 24.01 C ATOM 469 OD1 ASN A 45 −67.470 39.013 −17.395 1.00 23.81 O ATOM 470 ND2 ASN A 45 −69.111 37.490 −17.344 1.00 23.28 N ATOM 473 C ASN A 45 −70.177 42.014 −16.114 1.00 25.52 C ATOM 474 O ASN A 45 −69.704 42.836 −16.890 1.00 25.40 O ATOM 476 N ASN A 46 −71.308 42.210 −15.437 1.00 26.33 N ATOM 477 CA ASN A 46 −72.085 43.453 −15.468 1.00 26.72 C ATOM 479 CB ASN A 46 −73.102 43.404 −14.322 1.00 26.31 C ATOM 482 CG ASN A 46 −73.935 44.641 −14.209 1.00 24.24 C ATOM 483 OD1 ASN A 46 −73.948 45.472 −15.091 1.00 22.38 O ATOM 484 ND2 ASN A 46 −74.645 44.766 −13.106 1.00 21.64 N ATOM 487 C ASN A 46 −71.185 44.680 −15.349 1.00 28.11 C ATOM 488 O ASN A 46 −70.603 44.933 −14.304 1.00 28.16 O ATOM 490 N GLU A 47 −71.084 45.441 −16.433 1.00 29.93 N ATOM 491 CA GLU A 47 −70.128 46.558 −16.544 1.00 31.30 C ATOM 493 CB GLU A 47 −69.933 46.969 −18.013 1.00 31.28 C ATOM 496 CG GLU A 47 −69.737 45.795 −19.020 1.00 32.37 C ATOM 499 CD GLU A 47 −71.060 45.127 −19.545 1.00 32.69 C ATOM 500 OE1 GLU A 47 −72.055 45.833 −19.816 1.00 32.16 O ATOM 501 OE2 GLU A 47 −71.087 43.880 −19.699 1.00 32.41 O ATOM 502 C GLU A 47 −70.582 47.774 −15.729 1.00 32.47 C ATOM 503 O GLU A 47 −69.760 48.525 −15.230 1.00 32.86 O ATOM 505 N LYS A 48 −71.898 47.945 −15.585 1.00 33.93 N ATOM 506 CA LYS A 48 −72.491 49.075 −14.861 1.00 34.85 C ATOM 508 CB LYS A 48 −73.660 49.672 −15.684 1.00 35.08 C ATOM 511 CG LYS A 48 −73.221 50.119 −17.126 1.00 36.58 C ATOM 514 CD LYS A 48 −74.035 51.277 −17.751 1.00 37.93 C ATOM 517 CE LYS A 48 −75.353 50.799 −18.415 1.00 39.02 C ATOM 520 NZ LYS A 48 −75.159 49.990 −19.669 1.00 39.11 N ATOM 524 C LYS A 48 −72.926 48.632 −13.465 1.00 35.26 C ATOM 525 O LYS A 48 −74.011 48.954 −13.015 1.00 35.04 O ATOM 527 N ALA A 49 −72.051 47.890 −12.790 1.00 36.29 N ATOM 528 CA ALA A 49 −72.321 47.348 −11.456 1.00 37.18 C ATOM 530 CB ALA A 49 −71.828 45.923 −11.353 1.00 37.20 C ATOM 534 C ALA A 49 −71.618 48.191 −10.418 1.00 37.88 C ATOM 535 O ALA A 49 −70.480 48.610 −10.638 1.00 38.17 O ATOM 537 N GLU A 50 −72.278 48.404 −9.280 1.00 38.53 N ATOM 538 CA GLU A 50 −71.730 49.242 −8.213 1.00 39.08 C ATOM 540 CB GLU A 50 −72.790 49.545 −7.146 1.00 39.43 C ATOM 543 CG GLU A 50 −72.708 50.953 −6.600 1.00 40.86 C ATOM 546 CD GLU A 50 −73.089 52.010 −7.639 1.00 42.77 C ATOM 547 OE1 GLU A 50 −74.225 52.530 −7.570 1.00 45.07 O ATOM 548 OE2 GLU A 50 −72.265 52.320 −8.530 1.00 43.35 O ATOM 549 C GLU A 50 −70.560 48.521 −7.600 1.00 38.89 C ATOM 550 O GLU A 50 −70.699 47.378 −7.201 1.00 39.05 O ATOM 552 N PHE A 51 −69.411 49.181 −7.536 1.00 38.99 N ATOM 553 CA PHE A 51 −68.161 48.502 −7.196 1.00 39.52 C ATOM 555 CB PHE A 51 −67.000 49.494 −7.098 1.00 40.05 C ATOM 558 CG PHE A 51 −66.460 49.948 −8.431 1.00 42.80 C ATOM 559 CD1 PHE A 51 −66.135 49.014 −9.435 1.00 45.21 C ATOM 561 CE1 PHE A 51 −65.612 49.425 −10.675 1.00 46.12 C ATOM 563 CZ PHE A 51 −65.403 50.790 −10.917 1.00 47.21 C ATOM 565 CE2 PHE A 51 −65.726 51.741 −9.913 1.00 46.72 C ATOM 567 CD2 PHE A 51 −66.247 51.310 −8.679 1.00 45.05 C ATOM 569 C PHE A 51 −68.223 47.687 −5.905 1.00 39.05 C ATOM 570 O PHE A 51 −67.897 46.506 −5.900 1.00 39.28 O ATOM 572 N LEU A 52 −68.648 48.307 −4.813 1.00 38.42 N ATOM 573 CA LEU A 52 −68.709 47.610 −3.528 1.00 37.94 C ATOM 575 CB LEU A 52 −69.084 48.594 −2.413 1.00 38.53 C ATOM 578 CG LEU A 52 −68.057 49.726 −2.181 1.00 40.46 C ATOM 580 CD1 LEU A 52 −68.691 51.101 −1.787 1.00 41.88 C ATOM 584 CD2 LEU A 52 −67.020 49.274 −1.141 1.00 41.83 C ATOM 588 C LEU A 52 −69.667 46.406 −3.532 1.00 36.72 C ATOM 589 O LEU A 52 −69.517 45.494 −2.724 1.00 36.84 O ATOM 591 N THR A 53 −70.649 46.398 −4.431 1.00 35.37 N ATOM 592 CA THR A 53 −71.545 45.247 −4.569 1.00 34.11 C ATOM 594 CB THR A 53 −72.867 45.594 −5.277 1.00 33.87 C ATOM 596 OG1 THR A 53 −73.339 46.863 −4.828 1.00 33.49 O ATOM 598 CG2 THR A 53 −73.917 44.535 −4.983 1.00 33.70 C ATOM 602 C THR A 53 −70.853 44.148 −5.359 1.00 33.04 C ATOM 603 O THR A 53 −70.893 42.977 −4.973 1.00 32.90 O ATOM 605 N LEU A 54 −70.228 44.528 −6.467 1.00 31.76 N ATOM 606 CA LEU A 54 −69.469 43.578 −7.286 1.00 31.13 C ATOM 608 CB LEU A 54 −68.721 44.308 −8.392 1.00 30.92 C ATOM 611 CG LEU A 54 −68.028 43.437 −9.424 1.00 30.27 C ATOM 613 CD1 LEU A 54 −69.034 42.769 −10.310 1.00 29.56 C ATOM 617 CD2 LEU A 54 −67.108 44.306 −10.242 1.00 31.15 C ATOM 621 C LEU A 54 −68.466 42.808 −6.443 1.00 30.60 C ATOM 622 O LEU A 54 −68.378 41.587 −6.543 1.00 30.30 O ATOM 624 N LEU A 55 −67.725 43.551 −5.618 1.00 30.09 N ATOM 625 CA LEU A 55 −66.730 43.000 −4.695 1.00 29.47 C ATOM 627 CB LEU A 55 −66.006 44.126 −3.944 1.00 29.44 C ATOM 630 CG LEU A 55 −65.069 45.017 −4.781 1.00 29.74 C ATOM 632 CD1 LEU A 55 −64.609 46.255 −4.003 1.00 29.43 C ATOM 636 CD2 LEU A 55 −63.859 44.234 −5.286 1.00 29.64 C ATOM 640 C LEU A 55 −67.340 42.024 −3.696 1.00 28.87 C ATOM 641 O LEU A 55 −66.746 40.991 −3.383 1.00 28.98 O ATOM 643 N GLU A 56 −68.525 42.330 −3.198 1.00 28.01 N ATOM 644 CA GLU A 56 −69.160 41.419 −2.256 1.00 27.64 C ATOM 646 CB GLU A 56 −70.172 42.173 −1.395 1.00 28.19 C ATOM 649 CG GLU A 56 −69.497 43.167 −.459 1.00 29.75 C ATOM 652 CD GLU A 56 −70.457 43.858 .478 1.00 33.04 C ATOM 653 OE1 GLU A 56 −71.667 43.538 .481 1.00 34.46 O ATOM 654 OE2 GLU A 56 −69.988 44.737 1.226 1.00 36.78 O ATOM 655 C GLU A 56 −69.776 40.200 −2.945 1.00 26.37 C ATOM 656 O GLU A 56 −69.914 39.146 −2.333 1.00 26.02 O ATOM 658 N LEU A 57 −70.134 40.347 −4.218 1.00 25.30 N ATOM 659 CA LEU A 57 −70.569 39.212 −5.036 1.00 24.17 C ATOM 661 CB LEU A 57 −71.125 39.680 −6.382 1.00 23.71 C ATOM 664 CG LEU A 57 −71.417 38.568 −7.390 1.00 22.27 C ATOM 666 CD1 LEU A 57 −72.515 37.675 −6.858 1.00 19.31 C ATOM 670 CD2 LEU A 57 −71.752 39.167 −8.768 1.00 20.30 C ATOM 674 C LEU A 57 −69.404 38.267 −5.284 1.00 23.69 C ATOM 675 O LEU A 57 −69.547 37.051 −5.136 1.00 23.83 O ATOM 677 N ILE A 58 −68.261 38.822 −5.682 1.00 22.82 N ATOM 678 CA ILE A 58 −67.070 38.019 −5.925 1.00 22.39 C ATOM 680 CB ILE A 58 −65.884 38.899 −6.355 1.00 22.21 C ATOM 682 CG1 ILE A 58 −66.088 39.386 −7.792 1.00 21.83 C ATOM 685 CD1 ILE A 58 −65.002 40.314 −8.320 1.00 20.43 C ATOM 689 CG2 ILE A 58 −64.565 38.131 −6.245 1.00 22.64 C ATOM 693 C ILE A 58 −66.719 37.227 −4.662 1.00 22.35 C ATOM 694 O ILE A 58 −66.520 36.002 −4.706 1.00 21.95 O ATOM 696 N ASP A 59 −66.676 37.951 −3.543 1.00 22.32 N ATOM 697 CA ASP A 59 −66.396 37.396 −2.215 1.00 22.26 C ATOM 699 CB ASP A 59 −66.570 38.500 −1.171 1.00 22.67 C ATOM 702 CG ASP A 59 −66.126 38.092 .213 1.00 23.91 C ATOM 703 OD1 ASP A 59 −65.271 37.182 .338 1.00 23.77 O ATOM 704 OD2 ASP A 59 −66.641 38.718 1.178 1.00 27.12 O ATOM 705 C ASP A 59 −67.304 36.216 −1.901 1.00 21.79 C ATOM 706 O ASP A 59 −66.828 35.102 −1.668 1.00 21.71 O ATOM 708 N ASN A 60 −68.610 36.466 −1.926 1.00 21.51 N ATOM 709 CA ASN A 60 −69.619 35.418 −1.759 1.00 21.28 C ATOM 711 CB ASN A 60 −71.012 36.006 −1.958 1.00 21.25 C ATOM 714 CG ASN A 60 −71.476 36.827 −.776 1.00 21.82 C ATOM 715 OD1 ASN A 60 −71.067 36.598 .364 1.00 20.81 O ATOM 716 ND2 ASN A 60 −72.361 37.783 −1.043 1.00 23.63 N ATOM 719 C ASN A 60 −69.445 34.240 −2.725 1.00 21.22 C ATOM 720 O ASN A 60 −69.444 33.053 −2.303 1.00 20.95 O ATOM 722 N VAL A 61 −69.308 34.566 −4.018 1.00 20.83 N ATOM 723 CA VAL A 61 −69.147 33.536 −5.043 1.00 20.57 C ATOM 725 CB VAL A 61 −68.915 34.122 −6.466 1.00 20.53 C ATOM 727 CG1 VAL A 61 −68.382 33.042 −7.430 1.00 19.44 C ATOM 731 CG2 VAL A 61 −70.190 34.758 −7.006 1.00 19.75 C ATOM 735 C VAL A 61 −67.981 32.646 −4.644 1.00 20.62 C ATOM 736 O VAL A 61 −68.080 31.431 −4.699 1.00 20.56 O ATOM 738 N GLN A 62 −66.888 33.255 −4.209 1.00 20.76 N ATOM 739 CA GLN A 62 −65.703 32.481 −3.898 1.00 21.18 C ATOM 741 CB GLN A 62 −64.461 33.379 −3.824 1.00 21.39 C ATOM 744 CG GLN A 62 −64.007 33.920 −5.165 1.00 21.64 C ATOM 747 CD GLN A 62 −62.608 34.512 −5.135 1.00 22.04 C ATOM 748 OE1 GLN A 62 −61.890 34.483 −6.145 1.00 23.18 O ATOM 749 NE2 GLN A 62 −62.217 35.062 −3.989 1.00 20.39 N ATOM 752 C GLN A 62 −65.891 31.681 −2.607 1.00 21.09 C ATOM 753 O GLN A 62 −65.544 30.485 −2.554 1.00 21.30 O ATOM 755 N ARG A 63 −66.448 32.325 −1.583 1.00 20.63 N ATOM 756 CA ARG A 63 −66.590 31.677 −.273 1.00 20.54 C ATOM 758 CB ARG A 63 −67.025 32.686 .786 1.00 20.57 C ATOM 761 CG ARG A 63 −66.031 33.823 .930 1.00 22.55 C ATOM 764 CD ARG A 63 −66.214 34.632 2.179 1.00 24.93 C ATOM 767 NE ARG A 63 −66.123 33.781 3.355 1.00 27.75 N ATOM 769 CZ ARG A 63 −66.496 34.151 4.573 1.00 30.24 C ATOM 770 NH1 ARG A 63 −66.971 35.385 4.782 1.00 31.79 N ATOM 773 NH2 ARG A 63 −66.399 33.285 5.581 1.00 30.07 N ATOM 776 C ARG A 63 −67.557 30.499 −.338 1.00 19.81 C ATOM 777 O ARG A 63 −67.283 29.431 .209 1.00 19.67 O ATOM 779 N LEU A 64 −68.661 30.684 −1.057 1.00 19.04 N ATOM 780 CA LEU A 64 −69.636 29.617 −1.246 1.00 18.44 C ATOM 782 CB LEU A 64 −70.865 30.167 −1.954 1.00 18.59 C ATOM 785 CG LEU A 64 −71.662 31.170 −1.140 1.00 18.32 C ATOM 787 CD1 LEU A 64 −72.669 31.852 −2.034 1.00 18.10 C ATOM 791 CD2 LEU A 64 −72.334 30.444 .004 1.00 18.29 C ATOM 795 C LEU A 64 −69.089 28.436 −2.037 1.00 17.80 C ATOM 796 O LEU A 64 −69.802 27.453 −2.252 1.00 17.79 O ATOM 798 N GLY A 65 −67.850 28.573 −2.515 1.00 17.07 N ATOM 799 CA GLY A 65 −67.084 27.480 −3.081 1.00 16.27 C ATOM 802 C GLY A 65 −67.137 27.406 −4.588 1.00 15.77 C ATOM 803 O GLY A 65 −66.893 26.347 −5.154 1.00 15.78 O ATOM 805 N LEU A 66 −67.439 28.521 −5.246 1.00 15.24 N ATOM 806 CA LEU A 66 −67.621 28.537 −6.701 1.00 14.93 C ATOM 808 CB LEU A 66 −68.977 29.146 −7.021 1.00 14.84 C ATOM 811 CG LEU A 66 −70.204 28.334 −6.619 1.00 13.97 C ATOM 813 CD1 LEU A 66 −71.391 29.260 −6.650 1.00 13.74 C ATOM 817 CD2 LEU A 66 −70.415 27.125 −7.534 1.00 11.22 C ATOM 821 C LEU A 66 −66.533 29.314 −7.454 1.00 15.09 C ATOM 822 O LEU A 66 −66.621 29.497 −8.678 1.00 14.81 O ATOM 824 N GLY A 67 −65.510 29.758 −6.720 1.00 15.21 N ATOM 825 CA GLY A 67 −64.404 30.526 −7.280 1.00 14.98 C ATOM 828 C GLY A 67 −63.873 29.952 −8.569 1.00 14.60 C ATOM 829 O GLY A 67 −63.891 30.619 −9.579 1.00 14.63 O ATOM 831 N TYR A 68 −63.419 28.706 −8.523 1.00 14.57 N ATOM 832 CA TYR A 68 −62.831 28.029 −9.688 1.00 14.72 C ATOM 834 CB TYR A 68 −62.608 26.539 −9.372 1.00 14.73 C ATOM 837 CG TYR A 68 −63.858 25.689 −9.330 1.00 12.47 C ATOM 838 CD1 TYR A 68 −64.163 24.826 −10.366 1.00 10.68 C ATOM 840 CE1 TYR A 68 −65.310 24.043 −10.340 1.00 10.55 C ATOM 842 CZ TYR A 68 −66.163 24.119 −9.258 1.00 10.41 C ATOM 843 OH TYR A 68 −67.311 23.349 −9.212 1.00 6.97 O ATOM 845 CE2 TYR A 68 −65.864 24.979 −8.210 1.00 11.44 C ATOM 847 CD2 TYR A 68 −64.722 25.750 −8.252 1.00 11.29 C ATOM 849 C TYR A 68 −63.648 28.141 −10.980 1.00 15.31 C ATOM 850 O TYR A 68 −63.106 28.230 −12.083 1.00 15.01 O ATOM 852 N ARG A 69 −64.959 28.136 −10.816 1.00 16.03 N ATOM 853 CA ARG A 69 −65.884 28.083 −11.922 1.00 16.67 C ATOM 855 CB ARG A 69 −67.224 27.649 −11.348 1.00 16.58 C ATOM 858 CG ARG A 69 −68.332 27.445 −12.335 1.00 16.07 C ATOM 861 CD ARG A 69 −69.378 26.578 −11.701 1.00 14.26 C ATOM 864 NE ARG A 69 −68.915 25.205 −11.677 1.00 12.82 N ATOM 866 CZ ARG A 69 −69.063 24.346 −12.676 1.00 12.42 C ATOM 867 NH1 ARG A 69 −69.676 24.694 −13.792 1.00 12.27 N ATOM 870 NH2 ARG A 69 −68.601 23.119 −12.553 1.00 13.23 N ATOM 873 C ARG A 69 −66.010 29.409 −12.692 1.00 17.62 C ATOM 874 O ARG A 69 −66.281 29.401 −13.892 1.00 17.10 O ATOM 876 N PHE A 70 −65.811 30.529 −11.985 1.00 19.11 N ATOM 877 CA PHE A 70 −65.936 31.891 −12.530 1.00 19.96 C ATOM 879 CB PHE A 70 −67.024 32.666 −11.763 1.00 19.89 C ATOM 882 CG PHE A 70 −68.365 32.010 −11.784 1.00 18.68 C ATOM 883 CD1 PHE A 70 −69.158 32.082 −12.903 1.00 18.05 C ATOM 885 CE1 PHE A 70 −70.376 31.452 −12.938 1.00 18.03 C ATOM 887 CZ PHE A 70 −70.825 30.754 −11.851 1.00 17.26 C ATOM 889 CE2 PHE A 70 −70.051 30.672 −10.736 1.00 17.60 C ATOM 891 CD2 PHE A 70 −68.822 31.300 −10.700 1.00 17.86 C ATOM 893 C PHE A 70 −64.627 32.661 −12.400 1.00 21.34 C ATOM 894 O PHE A 70 −64.629 33.862 −12.171 1.00 21.25 O ATOM 896 N GLU A 71 −63.501 31.977 −12.541 1.00 23.19 N ATOM 897 CA GLU A 71 −62.211 32.591 −12.214 1.00 24.60 C ATOM 899 CB GLU A 71 −61.127 31.524 −12.073 1.00 25.03 C ATOM 902 CG GLU A 71 −59.717 32.059 −11.861 1.00 27.10 C ATOM 905 CD GLU A 71 −58.712 30.949 −11.549 1.00 30.10 C ATOM 906 OE1 GLU A 71 −59.084 30.007 −10.796 1.00 32.05 O ATOM 907 OE2 GLU A 71 −57.558 31.027 −12.051 1.00 30.50 O ATOM 908 C GLU A 71 −61.809 33.644 −13.241 1.00 25.23 C ATOM 909 O GLU A 71 −61.362 34.717 −12.862 1.00 25.54 O ATOM 911 N SER A 72 −61.979 33.345 −14.530 1.00 25.91 N ATOM 912 CA SER A 72 −61.641 34.294 −15.588 1.00 26.37 C ATOM 914 CB SER A 72 −61.656 33.606 −16.941 1.00 26.32 C ATOM 917 OG SER A 72 −62.985 33.278 −17.291 1.00 27.28 O ATOM 919 C SER A 72 −62.609 35.476 −15.608 1.00 26.84 C ATOM 920 O SER A 72 −62.197 36.601 −15.852 1.00 27.02 O ATOM 922 N ASP A 73 −63.893 35.214 −15.361 1.00 27.45 N ATOM 923 CA ASP A 73 −64.895 36.277 −15.246 1.00 27.87 C ATOM 925 CB ASP A 73 −66.289 35.705 −14.968 1.00 27.99 C ATOM 928 CG ASP A 73 −66.842 34.913 −16.140 1.00 29.49 C ATOM 929 OD1 ASP A 73 −67.215 35.530 −17.155 1.00 30.90 O ATOM 930 OD2 ASP A 73 −66.916 33.667 −16.054 1.00 31.85 O ATOM 931 C ASP A 73 −64.518 37.221 −14.121 1.00 27.86 C ATOM 932 O ASP A 73 −64.598 38.435 −14.286 1.00 28.05 O ATOM 934 N ILE A 74 −64.118 36.652 −12.985 1.00 27.88 N ATOM 935 CA ILE A 74 −63.698 37.422 −11.821 1.00 27.98 C ATOM 937 CB ILE A 74 −63.348 36.521 −10.637 1.00 27.71 C ATOM 939 CG1 ILE A 74 −64.607 36.007 −9.960 1.00 27.60 C ATOM 942 CD1 ILE A 74 −64.355 34.846 −9.023 1.00 27.67 C ATOM 946 CG2 ILE A 74 −62.551 37.272 −9.621 1.00 26.82 C ATOM 950 C ILE A 74 −62.472 38.252 −12.133 1.00 28.80 C ATOM 951 O ILE A 74 −62.475 39.453 −11.917 1.00 29.00 O ATOM 953 N ARG A 75 −61.415 37.616 −12.628 1.00 29.80 N ATOM 954 CA ARG A 75 −60.197 38.341 −12.968 1.00 30.79 C ATOM 956 CB ARG A 75 −59.286 37.507 −13.841 1.00 31.33 C ATOM 959 CG ARG A 75 −58.506 36.441 −13.115 1.00 34.25 C ATOM 962 CD ARG A 75 −57.286 36.009 −13.929 1.00 37.53 C ATOM 965 NE ARG A 75 −56.238 37.019 −13.799 1.00 40.89 N ATOM 967 CZ ARG A 75 −54.934 36.807 −13.967 1.00 44.24 C ATOM 968 NH1 ARG A 75 −54.459 35.602 −14.294 1.00 45.02 N ATOM 971 NH2 ARG A 75 −54.089 37.821 −13.796 1.00 45.88 N ATOM 974 C ARG A 75 −60.548 39.596 −13.727 1.00 30.95 C ATOM 975 O ARG A 75 −60.163 40.685 −13.336 1.00 31.27 O ATOM 977 N ARG A 76 −61.293 39.435 −14.815 1.00 31.31 N ATOM 978 CA ARG A 76 −61.712 40.567 −15.638 1.00 31.62 C ATOM 980 CB ARG A 76 −62.593 40.106 −16.794 1.00 31.97 C ATOM 983 CG ARG A 76 −61.833 39.392 −17.895 1.00 32.91 C ATOM 986 CD ARG A 76 −62.615 39.453 −19.205 1.00 34.43 C ATOM 989 NE ARG A 76 −63.925 38.803 −19.128 1.00 35.66 N ATOM 991 CZ ARG A 76 −64.115 37.480 −19.106 1.00 37.15 C ATOM 992 NH1 ARG A 76 −63.085 36.632 −19.129 1.00 37.93 N ATOM 995 NH2 ARG A 76 −65.347 36.992 −19.048 1.00 37.64 N ATOM 998 C ARG A 76 −62.453 41.629 −14.849 1.00 31.41 C ATOM 999 O ARG A 76 −62.144 42.798 −14.966 1.00 31.35 O ATOM 1001 N ALA A 77 −63.437 41.230 −14.058 1.00 31.53 N ATOM 1002 CA ALA A 77 −64.136 42.177 −13.211 1.00 31.73 C ATOM 1004 CB ALA A 77 −65.074 41.468 −12.275 1.00 31.69 C ATOM 1008 C ALA A 77 −63.107 42.950 −12.423 1.00 32.23 C ATOM 1009 O ALA A 77 −63.116 44.176 −12.411 1.00 32.42 O ATOM 1011 N LEU A 78 −62.198 42.223 −11.786 1.00 32.95 N ATOM 1012 CA LEU A 78 −61.168 42.838 −10.963 1.00 33.51 C ATOM 1014 CB LEU A 78 −60.319 41.775 −10.265 1.00 33.10 C ATOM 1017 CG LEU A 78 −60.959 41.077 −9.081 1.00 32.30 C ATOM 1019 CD1 LEU A 78 −59.960 40.104 −8.472 1.00 30.80 C ATOM 1023 CD2 LEU A 78 −61.438 42.117 −8.056 1.00 31.89 C ATOM 1027 C LEU A 78 −60.249 43.752 −11.753 1.00 34.70 C ATOM 1028 O LEU A 78 −59.790 44.753 −11.214 1.00 35.18 O ATOM 1030 N ASP A 79 −59.955 43.404 −13.007 1.00 35.91 N ATOM 1031 CA ASP A 79 −59.054 44.205 −13.828 1.00 36.89 C ATOM 1033 CB ASP A 79 −58.637 43.452 −15.083 1.00 37.06 C ATOM 1036 CG ASP A 79 −57.518 44.150 −15.821 1.00 38.41 C ATOM 1037 OD1 ASP A 79 −57.800 45.080 −16.615 1.00 39.85 O ATOM 1038 OD2 ASP A 79 −56.347 43.775 −15.592 1.00 40.78 O ATOM 1039 C ASP A 79 −59.721 45.505 −14.220 1.00 37.75 C ATOM 1040 O ASP A 79 −59.105 46.568 −14.177 1.00 37.82 O ATOM 1042 N ARG A 80 −60.984 45.401 −14.615 1.00 38.99 N ATOM 1043 CA ARG A 80 −61.814 46.558 −14.923 1.00 39.88 C ATOM 1045 CB ARG A 80 −63.191 46.106 −15.427 1.00 40.41 C ATOM 1048 CG ARG A 80 −64.025 47.183 −16.122 1.00 42.77 C ATOM 1051 CD ARG A 80 −65.347 46.624 −16.718 1.00 45.79 C ATOM 1054 NE ARG A 80 −66.107 45.799 −15.765 1.00 48.55 N ATOM 1056 CZ ARG A 80 −66.136 44.457 −15.742 1.00 50.37 C ATOM 1057 NH1 ARG A 80 −65.450 43.724 −16.636 1.00 49.78 N ATOM 1060 NH2 ARG A 80 −66.868 43.835 −14.805 1.00 50.77 N ATOM 1063 C ARG A 80 −61.946 47.409 −13.668 1.00 39.80 C ATOM 1064 O ARG A 80 −61.840 48.630 −13.742 1.00 40.37 O ATOM 1066 N PHE A 81 −62.136 46.771 −12.516 1.00 39.62 N ATOM 1067 CA PHE A 81 −62.216 47.505 −11.245 1.00 39.61 C ATOM 1069 CB PHE A 81 −62.392 46.561 −10.053 1.00 39.74 C ATOM 1072 CG PHE A 81 −62.282 47.247 −8.712 1.00 38.81 C ATOM 1073 CD1 PHE A 81 −63.238 48.153 −8.315 1.00 39.03 C ATOM 1075 CE1 PHE A 81 −63.153 48.787 −7.100 1.00 39.69 C ATOM 1077 CZ PHE A 81 −62.095 48.515 −6.261 1.00 39.54 C ATOM 1079 CE2 PHE A 81 −61.134 47.608 −6.647 1.00 38.66 C ATOM 1081 CD2 PHE A 81 −61.228 46.986 −7.865 1.00 38.27 C ATOM 1083 C PHE A 81 −61.006 48.378 −10.970 1.00 39.58 C ATOM 1084 O PHE A 81 −61.165 49.535 −10.581 1.00 39.76 O ATOM 1086 N VAL A 82 −59.810 47.817 −11.142 1.00 39.50 N ATOM 1087 CA VAL A 82 −58.575 48.562 −10.892 1.00 39.47 C ATOM 1089 CB VAL A 82 −57.314 47.659 −10.977 1.00 39.37 C ATOM 1091 CG1 VAL A 82 −56.108 48.426 −11.521 1.00 39.06 C ATOM 1095 CG2 VAL A 82 −57.009 47.079 −9.614 1.00 39.23 C ATOM 1099 C VAL A 82 −58.457 49.755 −11.833 1.00 39.54 C ATOM 1100 O VAL A 82 −58.222 50.884 −11.378 1.00 39.45 O ATOM 1102 N SER A 83 −58.678 49.513 −13.126 1.00 39.65 N ATOM 1103 CA SER A 83 −58.469 50.535 −14.157 1.00 39.82 C ATOM 1105 CB SER A 83 −58.196 49.880 −15.526 1.00 39.84 C ATOM 1108 OG SER A 83 −59.138 48.870 −15.829 1.00 40.00 O ATOM 1110 C SER A 83 −59.617 51.561 −14.219 1.00 39.62 C ATOM 1111 O SER A 83 −60.149 51.853 −15.286 1.00 39.59 O ATOM 1113 N SER A 84 −59.957 52.108 −13.052 1.00 39.44 N ATOM 1114 CA SER A 84 −60.926 53.197 −12.910 1.00 39.13 C ATOM 1116 CB SER A 84 −62.238 52.834 −13.618 1.00 39.03 C ATOM 1119 OG SER A 84 −62.620 51.505 −13.325 1.00 37.97 O ATOM 1121 C SER A 84 −61.243 53.580 −11.446 1.00 39.17 C ATOM 1122 O SER A 84 −62.189 54.341 −11.230 1.00 39.58 O ATOM 1124 N GLY A 85 −60.482 53.077 −10.457 1.00 38.74 N ATOM 1125 CA GLY A 85 −60.795 53.282 −9.024 1.00 38.26 C ATOM 1128 C GLY A 85 −61.724 52.238 −8.413 1.00 37.79 C ATOM 1129 O GLY A 85 −61.529 51.799 −7.273 1.00 36.84 O ATOM 1131 N SER A 94 −63.557 54.187 1.994 1.00 28.27 N ATOM 1132 CA SER A 94 −64.069 52.892 2.476 1.00 28.03 C ATOM 1134 CB SER A 94 −64.856 52.225 1.359 1.00 27.84 C ATOM 1137 OG SER A 94 −65.234 50.921 1.743 1.00 28.20 O ATOM 1139 C SER A 94 −62.992 51.910 2.934 1.00 27.83 C ATOM 1140 O SER A 94 −62.339 51.325 2.090 1.00 28.15 O ATOM 1142 N LEU A 95 −62.815 51.705 4.245 1.00 27.70 N ATOM 1143 CA LEU A 95 −61.813 50.728 4.751 1.00 27.59 C ATOM 1145 CB LEU A 95 −61.692 50.747 6.282 1.00 27.49 C ATOM 1148 CG LEU A 95 −60.871 49.596 6.909 1.00 27.47 C ATOM 1150 CD1 LEU A 95 −59.400 49.900 6.902 1.00 27.70 C ATOM 1154 CD2 LEU A 95 −61.292 49.274 8.329 1.00 27.50 C ATOM 1158 C LEU A 95 −62.173 49.314 4.318 1.00 27.71 C ATOM 1159 O LEU A 95 −61.303 48.537 3.914 1.00 27.73 O ATOM 1161 N HIS A 96 −63.461 48.989 4.437 1.00 27.74 N ATOM 1162 CA HIS A 96 −64.003 47.715 3.977 1.00 27.54 C ATOM 1164 CB HIS A 96 −65.497 47.680 4.230 1.00 27.57 C ATOM 1167 CG HIS A 96 −66.161 46.482 3.654 1.00 28.65 C ATOM 1168 ND1 HIS A 96 −65.790 45.201 3.988 1.00 30.59 N ATOM 1170 CE1 HIS A 96 −66.540 44.341 3.325 1.00 31.88 C ATOM 1172 NE2 HIS A 96 −67.384 45.021 2.570 1.00 32.06 N ATOM 1174 CD2 HIS A 96 −67.166 46.364 2.758 1.00 30.47 C ATOM 1176 C HIS A 96 −63.705 47.450 2.492 1.00 27.09 C ATOM 1177 O HIS A 96 −63.128 46.425 2.150 1.00 27.18 O ATOM 1179 N GLY A 97 −64.079 48.386 1.625 1.00 26.55 N ATOM 1180 CA GLY A 97 −63.760 48.300 .205 1.00 26.26 C ATOM 1183 C GLY A 97 −62.277 48.112 −.088 1.00 26.23 C ATOM 1184 O GLY A 97 −61.918 47.334 −.974 1.00 26.39 O ATOM 1186 N THR A 98 −61.415 48.815 .653 1.00 25.83 N ATOM 1187 CA THR A 98 −59.967 48.755 .435 1.00 25.36 C ATOM 1189 CB THR A 98 −59.204 49.847 1.215 1.00 25.07 C ATOM 1191 OG1 THR A 98 −59.796 51.123 .980 1.00 23.62 O ATOM 1193 CG2 THR A 98 −57.755 49.905 .780 1.00 24.88 C ATOM 1197 C THR A 98 −59.416 47.389 .845 1.00 25.69 C ATOM 1198 O THR A 98 −58.622 46.802 .111 1.00 25.66 O ATOM 1200 N ALA A 99 −59.847 46.890 2.008 1.00 25.95 N ATOM 1201 CA ALA A 99 −59.468 45.540 2.495 1.00 25.93 C ATOM 1203 CB ALA A 99 −59.945 45.330 3.929 1.00 25.82 C ATOM 1207 C ALA A 99 −59.984 44.404 1.595 1.00 25.64 C ATOM 1208 O ALA A 99 −59.204 43.599 1.102 1.00 25.38 O ATOM 1210 N LEU A 100 −61.290 44.348 1.371 1.00 25.46 N ATOM 1211 CA LEU A 100 −61.856 43.335 .474 1.00 25.55 C ATOM 1213 CB LEU A 100 −63.361 43.540 .326 1.00 25.37 C ATOM 1216 CG LEU A 100 −64.118 42.464 −.443 1.00 25.41 C ATOM 1218 CD1 LEU A 100 −64.038 41.115 .281 1.00 26.01 C ATOM 1222 CD2 LEU A 100 −65.555 42.893 −.639 1.00 25.19 C ATOM 1226 C LEU A 100 −61.196 43.353 −.919 1.00 25.70 C ATOM 1227 O LEU A 100 −60.819 42.301 −1.469 1.00 25.36 O ATOM 1229 N SER A 101 −61.064 44.550 −1.489 1.00 25.77 N ATOM 1230 CA SER A 101 −60.434 44.688 −2.805 1.00 25.67 C ATOM 1232 CB SER A 101 −60.629 46.098 −3.375 1.00 25.83 C ATOM 1235 OG SER A 101 −59.840 47.064 −2.688 1.00 26.98 O ATOM 1237 C SER A 101 −58.947 44.336 −2.756 1.00 25.01 C ATOM 1238 O SER A 101 −58.427 43.705 −3.672 1.00 24.94 O ATOM 1240 N PHE A 102 −58.270 44.737 −1.687 1.00 24.30 N ATOM 1241 CA PHE A 102 −56.852 44.436 −1.560 1.00 23.99 C ATOM 1243 CB PHE A 102 −56.295 44.963 −.229 1.00 23.84 C ATOM 1246 CG PHE A 102 −54.860 44.606 .027 1.00 23.24 C ATOM 1247 CD1 PHE A 102 −53.849 45.504 −.259 1.00 23.56 C ATOM 1249 CE1 PHE A 102 −52.507 45.182 −.007 1.00 24.50 C ATOM 1251 CZ PHE A 102 −52.175 43.941 .540 1.00 24.27 C ATOM 1253 CE2 PHE A 102 −53.180 43.042 .834 1.00 23.95 C ATOM 1255 CD2 PHE A 102 −54.520 43.376 .576 1.00 23.45 C ATOM 1257 C PHE A 102 −56.673 42.928 −1.679 1.00 23.65 C ATOM 1258 O PHE A 102 −55.890 42.442 −2.501 1.00 23.55 O ATOM 1260 N ARG A 103 −57.443 42.202 −.880 1.00 23.20 N ATOM 1261 CA ARG A 103 −57.298 40.765 −.764 1.00 22.84 C ATOM 1263 CB ARG A 103 −58.250 40.231 .291 1.00 23.01 C ATOM 1266 CG ARG A 103 −58.054 38.774 .597 1.00 23.93 C ATOM 1269 CD ARG A 103 −58.703 38.376 1.937 1.00 23.84 C ATOM 1272 NE ARG A 103 −60.150 38.538 1.919 1.00 22.36 N ATOM 1274 CZ ARG A 103 −60.982 37.763 1.240 1.00 20.62 C ATOM 1275 NH1 ARG A 103 −60.512 36.773 .490 1.00 20.19 N ATOM 1278 NH2 ARG A 103 −62.288 38.003 1.293 1.00 20.32 N ATOM 1281 C ARG A 103 −57.602 40.117 −2.082 1.00 22.34 C ATOM 1282 O ARG A 103 −56.826 39.303 −2.576 1.00 22.37 O ATOM 1284 N LEU A 104 −58.729 40.496 −2.667 1.00 21.98 N ATOM 1285 CA LEU A 104 −59.129 39.926 −3.951 1.00 21.60 C ATOM 1287 CB LEU A 104 −60.503 40.442 −4.378 1.00 21.23 C ATOM 1290 CG LEU A 104 −61.590 39.832 −3.522 1.00 20.30 C ATOM 1292 CD1 LEU A 104 −62.949 40.401 −3.856 1.00 19.53 C ATOM 1296 CD2 LEU A 104 −61.554 38.344 −3.725 1.00 19.71 C ATOM 1300 C LEU A 104 −58.101 40.198 −5.040 1.00 21.48 C ATOM 1301 O LEU A 104 −57.743 39.294 −5.780 1.00 21.62 O ATOM 1303 N LEU A 105 −57.623 41.432 −5.139 1.00 21.14 N ATOM 1304 CA LEU A 105 −56.655 41.747 −6.173 1.00 21.05 C ATOM 1306 CB LEU A 105 −56.352 43.248 −6.205 1.00 20.94 C ATOM 1309 CG LEU A 105 −57.465 44.165 −6.732 1.00 20.06 C ATOM 1311 CD1 LEU A 105 −57.060 45.617 −6.580 1.00 17.92 C ATOM 1315 CD2 LEU A 105 −57.804 43.857 −8.174 1.00 19.18 C ATOM 1319 C LEU A 105 −55.372 40.908 −5.997 1.00 21.32 C ATOM 1320 O LEU A 105 −54.840 40.357 −6.976 1.00 21.37 O ATOM 1322 N ARG A 106 −54.893 40.777 −4.763 1.00 21.25 N ATOM 1323 CA ARG A 106 −53.678 40.003 −4.528 1.00 21.33 C ATOM 1325 CB ARG A 106 −53.151 40.211 −3.117 1.00 21.53 C ATOM 1328 CG ARG A 106 −51.772 39.588 −2.917 1.00 22.60 C ATOM 1331 CD ARG A 106 −51.098 40.091 −1.666 1.00 23.60 C ATOM 1334 NE ARG A 106 −50.374 41.330 −1.897 1.00 24.60 N ATOM 1336 CZ ARG A 106 −49.606 41.916 −.989 1.00 26.54 C ATOM 1337 NH1 ARG A 106 −49.469 41.380 .225 1.00 26.98 N ATOM 1340 NH2 ARG A 106 −48.967 43.041 −1.295 1.00 27.19 N ATOM 1343 C ARG A 106 −53.888 38.517 −4.767 1.00 21.19 C ATOM 1344 O ARG A 106 −52.998 37.821 −5.278 1.00 21.18 O ATOM 1346 N GLN A 107 −55.061 38.028 −4.378 1.00 21.09 N ATOM 1347 CA GLN A 107 −55.425 36.635 −4.618 1.00 20.76 C ATOM 1349 CB GLN A 107 −56.861 36.378 −4.168 1.00 20.51 C ATOM 1352 CG GLN A 107 −57.329 34.941 −4.327 1.00 19.68 C ATOM 1355 CD GLN A 107 −58.790 34.772 −4.010 1.00 18.26 C ATOM 1356 OE1 GLN A 107 −59.395 35.591 −3.334 1.00 17.44 O ATOM 1357 NE2 GLN A 107 −59.366 33.698 −4.497 1.00 18.48 N ATOM 1360 C GLN A 107 −55.304 36.306 −6.094 1.00 20.93 C ATOM 1361 O GLN A 107 −54.917 35.212 −6.447 1.00 21.45 O ATOM 1363 N HIS A 108 −55.642 37.260 −6.951 1.00 21.09 N ATOM 1364 CA HIS A 108 −55.686 37.030 −8.379 1.00 21.28 C ATOM 1366 CB HIS A 108 −57.024 37.541 −8.913 1.00 21.02 C ATOM 1369 CG HIS A 108 −58.182 36.706 −8.478 1.00 19.70 C ATOM 1370 ND1 HIS A 108 −58.637 35.632 −9.210 1.00 19.91 N ATOM 1372 CE1 HIS A 108 −59.641 35.060 −8.571 1.00 19.27 C ATOM 1374 NE2 HIS A 108 −59.851 35.720 −7.449 1.00 18.10 N ATOM 1376 CD2 HIS A 108 −58.950 36.753 −7.367 1.00 18.98 C ATOM 1378 C HIS A 108 −54.456 37.621 −9.108 1.00 22.21 C ATOM 1379 O HIS A 108 −54.505 37.980 −10.304 1.00 21.80 O ATOM 1381 N GLY A 109 −53.345 37.686 −8.375 1.00 23.19 N ATOM 1382 CA GLY A 109 −52.055 38.007 −8.956 1.00 24.17 C ATOM 1385 C GLY A 109 −51.813 39.470 −9.275 1.00 25.25 C ATOM 1386 O GLY A 109 −50.767 39.802 −9.845 1.00 25.26 O ATOM 1388 N PHE A 110 −52.755 40.349 −8.917 1.00 26.42 N ATOM 1389 CA PHE A 110 −52.575 41.783 −9.154 1.00 27.33 C ATOM 1391 CB PHE A 110 −53.895 42.546 −9.067 1.00 27.36 C ATOM 1394 CG PHE A 110 −54.838 42.250 −10.193 1.00 27.83 C ATOM 1395 CD1 PHE A 110 −54.633 42.801 −11.439 1.00 28.69 C ATOM 1397 CE1 PHE A 110 −55.490 42.529 −12.488 1.00 28.91 C ATOM 1399 CZ PHE A 110 −56.568 41.702 −12.295 1.00 28.85 C ATOM 1401 CE2 PHE A 110 −56.787 41.146 −11.060 1.00 28.67 C ATOM 1403 CD2 PHE A 110 −55.923 41.418 −10.013 1.00 28.39 C ATOM 1405 C PHE A 110 −51.582 42.369 −8.163 1.00 28.25 C ATOM 1406 O PHE A 110 −51.449 41.890 −7.024 1.00 28.71 O ATOM 1408 N GLU A 111 −50.886 43.411 −8.607 1.00 29.05 N ATOM 1409 CA GLU A 111 −49.951 44.142 −7.760 1.00 29.66 C ATOM 1411 CB GLU A 111 −48.902 44.803 −8.648 1.00 30.37 C ATOM 1414 CG GLU A 111 −47.750 45.509 −7.947 1.00 33.30 C ATOM 1417 CD GLU A 111 −46.916 46.342 −8.946 1.00 38.00 C ATOM 1418 OE1 GLU A 111 −46.312 45.750 −9.885 1.00 39.60 O ATOM 1419 OE2 GLU A 111 −46.886 47.594 −8.802 1.00 40.87 O ATOM 1420 C GLU A 111 −50.724 45.184 −6.935 1.00 28.98 C ATOM 1421 O GLU A 111 −51.293 46.123 −7.495 1.00 28.45 O ATOM 1423 N VAL A 112 −50.787 44.961 −5.618 1.00 28.47 N ATOM 1424 CA VAL A 112 −51.284 45.950 −4.655 1.00 28.09 C ATOM 1426 CB VAL A 112 −52.564 45.501 −3.908 1.00 27.76 C ATOM 1428 CG1 VAL A 112 −53.745 45.466 −4.836 1.00 27.38 C ATOM 1432 CG2 VAL A 112 −52.360 44.167 −3.252 1.00 27.80 C ATOM 1436 C VAL A 112 −50.193 46.199 −3.631 1.00 28.15 C ATOM 1437 O VAL A 112 −49.339 45.354 −3.436 1.00 27.90 O ATOM 1439 N SER A 113 −50.241 47.354 −2.974 1.00 28.54 N ATOM 1440 CA SER A 113 −49.194 47.782 −2.047 1.00 28.93 C ATOM 1442 CB SER A 113 −48.563 49.064 −2.564 1.00 29.12 C ATOM 1445 OG SER A 113 −47.692 49.644 −1.619 1.00 29.57 O ATOM 1447 C SER A 113 −49.780 48.041 −.685 1.00 29.13 C ATOM 1448 O SER A 113 −50.937 48.426 −.581 1.00 28.90 O ATOM 1450 N GLN A 114 −48.985 47.857 .367 1.00 29.84 N ATOM 1451 CA GLN A 114 −49.524 48.019 1.736 1.00 30.40 C ATOM 1453 CB GLN A 114 −48.568 47.507 2.830 1.00 30.34 C ATOM 1456 CG GLN A 114 −47.199 48.159 2.844 1.00 30.61 C ATOM 1459 CD GLN A 114 −46.456 47.928 4.147 1.00 30.77 C ATOM 1460 OE1 GLN A 114 −46.876 47.129 4.982 1.00 31.92 O ATOM 1461 NE2 GLN A 114 −45.341 48.624 4.324 1.00 30.02 N ATOM 1464 C GLN A 114 −49.939 49.440 2.068 1.00 30.62 C ATOM 1465 O GLN A 114 −50.573 49.644 3.094 1.00 30.73 O ATOM 1467 N GLU A 115 −49.592 50.407 1.216 1.00 30.94 N ATOM 1468 CA GLU A 115 −49.963 51.794 1.458 1.00 31.45 C ATOM 1470 CB GLU A 115 −48.881 52.777 .975 1.00 31.86 C ATOM 1473 CG GLU A 115 −48.489 52.723 −.509 1.00 33.48 C ATOM 1476 CD GLU A 115 −47.006 53.100 −.759 1.00 36.13 C ATOM 1477 OE1 GLU A 115 −46.106 52.668 .022 1.00 38.72 O ATOM 1478 OE2 GLU A 115 −46.741 53.811 −1.754 1.00 35.70 O ATOM 1479 C GLU A 115 −51.338 52.125 .895 1.00 31.45 C ATOM 1480 O GLU A 115 −51.716 53.283 .808 1.00 31.80 O ATOM 1482 N ALA A 116 −52.108 51.105 .549 1.00 31.58 N ATOM 1483 CA ALA A 116 −53.524 51.286 .284 1.00 31.67 C ATOM 1485 CB ALA A 116 −54.071 50.092 −.461 1.00 31.62 C ATOM 1489 C ALA A 116 −54.273 51.473 1.596 1.00 31.88 C ATOM 1490 O ALA A 116 −55.428 51.874 1.604 1.00 31.82 O ATOM 1492 N PHE A 117 −53.608 51.161 2.702 1.00 32.39 N ATOM 1493 CA PHE A 117 −54.193 51.271 4.030 1.00 32.87 C ATOM 1495 CB PHE A 117 −53.884 50.003 4.856 1.00 32.79 C ATOM 1498 CG PHE A 117 −54.539 48.758 4.323 1.00 31.03 C ATOM 1499 CD1 PHE A 117 −53.782 47.749 3.760 1.00 28.79 C ATOM 1501 CE1 PHE A 117 −54.379 46.620 3.265 1.00 28.36 C ATOM 1503 CZ PHE A 117 −55.754 46.489 3.316 1.00 29.50 C ATOM 1505 CE2 PHE A 117 −56.527 47.493 3.872 1.00 29.91 C ATOM 1507 CD2 PHE A 117 −55.917 48.613 4.375 1.00 30.09 C ATOM 1509 C PHE A 117 −53.683 52.493 4.773 1.00 33.71 C ATOM 1510 O PHE A 117 −54.012 52.678 5.937 1.00 33.61 O ATOM 1512 N SER A 118 −52.886 53.325 4.107 1.00 35.09 N ATOM 1513 CA SER A 118 −52.186 54.429 4.779 1.00 36.12 C ATOM 1515 CB SER A 118 −51.073 54.990 3.895 1.00 36.09 C ATOM 1518 OG SER A 118 −51.607 55.747 2.820 1.00 35.96 O ATOM 1520 C SER A 118 −53.134 55.552 5.184 1.00 37.17 C ATOM 1521 O SER A 118 −52.873 56.255 6.166 1.00 37.22 O ATOM 1523 N GLY A 119 −54.231 55.705 4.436 1.00 38.40 N ATOM 1524 CA GLY A 119 −55.227 56.735 4.708 1.00 39.47 C ATOM 1527 C GLY A 119 −56.255 56.398 5.778 1.00 40.62 C ATOM 1528 O GLY A 119 −57.259 57.086 5.877 1.00 40.74 O ATOM 1530 N PHE A 120 −56.024 55.344 6.563 1.00 42.13 N ATOM 1531 CA PHE A 120 −56.906 54.971 7.684 1.00 43.27 C ATOM 1533 CB PHE A 120 −57.510 53.586 7.455 1.00 43.21 C ATOM 1536 CG PHE A 120 −58.176 53.439 6.134 1.00 42.36 C ATOM 1537 CD1 PHE A 120 −59.418 54.006 5.911 1.00 41.23 C ATOM 1539 CE1 PHE A 120 −60.035 53.880 4.691 1.00 40.87 C ATOM 1541 CZ PHE A 120 −59.414 53.182 3.675 1.00 41.03 C ATOM 1543 CE2 PHE A 120 −58.167 52.618 3.883 1.00 40.92 C ATOM 1545 CD2 PHE A 120 −57.556 52.746 5.106 1.00 41.30 C ATOM 1547 C PHE A 120 −56.179 54.952 9.019 1.00 44.71 C ATOM 1548 O PHE A 120 −56.732 54.489 10.025 1.00 44.80 O ATOM 1550 N LYS A 121 −54.939 55.430 9.021 1.00 46.38 N ATOM 1551 CA LYS A 121 −54.153 55.519 10.235 1.00 47.81 C ATOM 1553 CB LYS A 121 −52.722 55.050 9.957 1.00 47.86 C ATOM 1556 CG LYS A 121 −52.648 53.537 9.648 1.00 48.24 C ATOM 1559 CD LYS A 121 −51.417 53.119 8.823 1.00 49.41 C ATOM 1562 CE LYS A 121 −50.095 53.142 9.621 1.00 49.88 C ATOM 1565 NZ LYS A 121 −49.944 52.005 10.584 1.00 49.89 N ATOM 1569 C LYS A 121 −54.257 56.964 10.735 1.00 49.00 C ATOM 1570 O LYS A 121 −54.712 57.839 10.000 1.00 49.11 O ATOM 1572 N ASP A 122 −53.899 57.206 11.995 1.00 50.51 N ATOM 1573 CA ASP A 122 −54.078 58.537 12.596 1.00 51.46 C ATOM 1575 CB ASP A 122 −54.604 58.443 14.050 1.00 51.29 C ATOM 1578 CG ASP A 122 −53.570 57.919 15.036 1.00 50.73 C ATOM 1579 OD1 ASP A 122 −52.353 58.025 14.777 1.00 49.90 O ATOM 1580 OD2 ASP A 122 −53.988 57.398 16.088 1.00 49.66 O ATOM 1581 C ASP A 122 −52.792 59.358 12.502 1.00 52.60 C ATOM 1582 O ASP A 122 −51.830 58.953 11.835 1.00 52.65 O ATOM 1584 N GLN A 123 −52.802 60.512 13.172 1.00 53.88 N ATOM 1585 CA GLN A 123 −51.680 61.456 13.195 1.00 54.66 C ATOM 1587 CB GLN A 123 −51.993 62.594 14.178 1.00 55.01 C ATOM 1590 CG GLN A 123 −53.249 63.442 13.831 1.00 56.15 C ATOM 1593 CD GLN A 123 −52.943 64.736 13.064 1.00 57.64 C ATOM 1594 OE1 GLN A 123 −51.779 65.102 12.859 1.00 59.10 O ATOM 1595 NE2 GLN A 123 −54.001 65.438 12.652 1.00 57.63 N ATOM 1598 C GLN A 123 −50.365 60.772 13.591 1.00 54.87 C ATOM 1599 O GLN A 123 −49.309 61.078 13.034 1.00 54.67 O ATOM 1601 N ASN A 124 −50.458 59.834 14.538 1.00 55.21 N ATOM 1602 CA ASN A 124 −49.300 59.137 15.109 1.00 55.39 C ATOM 1604 CB ASN A 124 −49.421 59.122 16.637 1.00 55.52 C ATOM 1607 CG ASN A 124 −49.833 60.478 17.202 1.00 55.98 C ATOM 1608 OD1 ASN A 124 −49.093 61.460 17.091 1.00 56.93 O ATOM 1609 ND2 ASN A 124 −51.026 60.540 17.797 1.00 55.99 N ATOM 1612 C ASN A 124 −49.116 57.705 14.589 1.00 55.27 C ATOM 1613 O ASN A 124 −48.530 56.864 15.271 1.00 55.18 O ATOM 1615 N GLY A 125 −49.626 57.430 13.391 1.00 55.18 N ATOM 1616 CA GLY A 125 −49.311 56.190 12.672 1.00 55.08 C ATOM 1619 C GLY A 125 −49.994 54.897 13.119 1.00 54.90 C ATOM 1620 O GLY A 125 −49.543 53.806 12.750 1.00 55.24 O ATOM 1622 N ASN A 126 −51.072 55.008 13.900 1.00 54.23 N ATOM 1623 CA ASN A 126 −51.871 53.853 14.329 1.00 53.39 C ATOM 1625 CB ASN A 126 −51.927 53.782 15.852 1.00 53.27 C ATOM 1628 CG ASN A 126 −50.596 53.425 16.466 1.00 52.81 C ATOM 1629 OD1 ASN A 126 −49.636 53.113 15.764 1.00 52.29 O ATOM 1630 ND2 ASN A 126 −50.532 53.460 17.789 1.00 52.53 N ATOM 1633 C ASN A 126 −53.274 53.978 13.771 1.00 52.82 C ATOM 1634 O ASN A 126 −53.724 55.081 13.494 1.00 52.69 O ATOM 1636 N PHE A 127 −53.968 52.857 13.607 1.00 52.17 N ATOM 1637 CA PHE A 127 −55.287 52.875 12.962 1.00 51.56 C ATOM 1639 CB PHE A 127 −55.805 51.451 12.721 1.00 51.35 C ATOM 1642 CG PHE A 127 −55.119 50.730 11.587 1.00 50.06 C ATOM 1643 CD1 PHE A 127 −54.068 49.856 11.831 1.00 48.90 C ATOM 1645 CE1 PHE A 127 −53.437 49.187 10.789 1.00 47.59 C ATOM 1647 CZ PHE A 127 −53.857 49.383 9.495 1.00 47.40 C ATOM 1649 CE2 PHE A 127 −54.906 50.244 9.234 1.00 47.96 C ATOM 1651 CD2 PHE A 127 −55.533 50.915 10.276 1.00 48.85 C ATOM 1653 C PHE A 127 −56.303 53.690 13.776 1.00 51.35 C ATOM 1654 O PHE A 127 −56.347 53.594 15.002 1.00 51.09 O ATOM 1656 N LEU A 128 −57.100 54.500 13.083 1.00 51.15 N ATOM 1657 CA LEU A 128 −58.143 55.280 13.727 1.00 51.09 C ATOM 1659 CB LEU A 128 −59.039 55.979 12.694 1.00 51.17 C ATOM 1662 CG LEU A 128 −58.463 57.046 11.746 1.00 51.31 C ATOM 1664 CD1 LEU A 128 −59.571 57.628 10.855 1.00 50.76 C ATOM 1668 CD2 LEU A 128 −57.762 58.157 12.508 1.00 50.98 C ATOM 1672 C LEU A 128 −58.996 54.353 14.581 1.00 51.06 C ATOM 1673 O LEU A 128 −59.573 53.393 14.078 1.00 50.94 O ATOM 1675 N GLU A 129 −59.053 54.637 15.879 1.00 51.12 N ATOM 1676 CA GLU A 129 −59.916 53.913 16.808 1.00 50.99 C ATOM 1678 CB GLU A 129 −60.019 54.665 18.132 1.00 51.14 C ATOM 1681 CG GLU A 129 −58.850 54.431 19.049 1.00 52.04 C ATOM 1684 CD GLU A 129 −58.903 53.069 19.697 1.00 53.22 C ATOM 1685 OE1 GLU A 129 −58.040 52.219 19.376 1.00 54.19 O ATOM 1686 OE2 GLU A 129 −59.823 52.848 20.516 1.00 53.51 O ATOM 1687 C GLU A 129 −61.314 53.712 16.260 1.00 50.66 C ATOM 1688 O GLU A 129 −61.791 52.587 16.200 1.00 50.83 O ATOM 1690 N ASN A 130 −61.960 54.799 15.839 1.00 50.28 N ATOM 1691 CA ASN A 130 −63.389 54.765 15.486 1.00 50.03 C ATOM 1693 CB ASN A 130 −63.910 56.182 15.193 1.00 50.09 C ATOM 1696 CG ASN A 130 −63.286 56.805 13.960 1.00 50.37 C ATOM 1697 OD1 ASN A 130 −62.504 56.177 13.249 1.00 51.44 O ATOM 1698 ND2 ASN A 130 −63.634 58.056 13.701 1.00 50.27 N ATOM 1701 C ASN A 130 −63.804 53.782 14.369 1.00 49.56 C ATOM 1702 O ASN A 130 −64.993 53.581 14.131 1.00 49.44 O ATOM 1704 N LEU A 131 −62.828 53.175 13.699 1.00 49.21 N ATOM 1705 CA LEU A 131 −63.087 52.103 12.729 1.00 48.78 C ATOM 1707 CB LEU A 131 −61.846 51.832 11.875 1.00 48.64 C ATOM 1710 CG LEU A 131 −61.445 52.939 10.898 1.00 48.26 C ATOM 1712 CD1 LEU A 131 −60.029 52.709 10.375 1.00 47.76 C ATOM 1716 CD2 LEU A 131 −62.441 53.039 9.754 1.00 47.32 C ATOM 1720 C LEU A 131 −63.516 50.798 13.394 1.00 48.58 C ATOM 1721 O LEU A 131 −64.093 49.939 12.731 1.00 48.64 O ATOM 1723 N LYS A 132 −63.225 50.645 14.689 1.00 48.23 N ATOM 1724 CA LYS A 132 −63.650 49.474 15.465 1.00 47.80 C ATOM 1726 CB LYS A 132 −63.156 49.587 16.913 1.00 47.71 C ATOM 1729 CG LYS A 132 −63.930 50.615 17.728 1.00 47.80 C ATOM 1732 CD LYS A 132 −63.430 50.779 19.153 1.00 47.75 C ATOM 1735 CE LYS A 132 −64.438 51.577 19.982 1.00 47.22 C ATOM 1738 NZ LYS A 132 −63.769 52.364 21.033 1.00 46.65 N ATOM 1742 C LYS A 132 −65.182 49.308 15.446 1.00 47.56 C ATOM 1743 O LYS A 132 −65.696 48.204 15.616 1.00 47.76 O ATOM 1745 N GLU A 133 −65.901 50.413 15.249 1.00 47.18 N ATOM 1746 CA GLU A 133 −67.371 50.412 15.191 1.00 46.79 C ATOM 1748 CB GLU A 133 −67.898 51.850 15.337 1.00 46.95 C ATOM 1751 CG GLU A 133 −67.840 52.376 16.776 1.00 47.56 C ATOM 1754 CD GLU A 133 −67.613 53.886 16.863 1.00 48.41 C ATOM 1755 OE1 GLU A 133 −68.247 54.648 16.093 1.00 47.67 O ATOM 1756 OE2 GLU A 133 −66.798 54.304 17.721 1.00 48.92 O ATOM 1757 C GLU A 133 −67.949 49.770 13.918 1.00 46.10 C ATOM 1758 O GLU A 133 −69.140 49.446 13.874 1.00 46.11 O ATOM 1760 N ASP A 134 −67.103 49.601 12.896 1.00 45.11 N ATOM 1761 CA ASP A 134 −67.477 48.995 11.608 1.00 44.06 C ATOM 1763 CB ASP A 134 −66.934 49.868 10.474 1.00 43.97 C ATOM 1766 CG ASP A 134 −67.380 49.411 9.104 1.00 44.08 C ATOM 1767 OD1 ASP A 134 −68.072 48.373 8.972 1.00 43.42 O ATOM 1768 OD2 ASP A 134 −67.020 50.116 8.141 1.00 44.84 O ATOM 1769 C ASP A 134 −66.910 47.570 11.526 1.00 43.12 C ATOM 1770 O ASP A 134 −65.788 47.357 11.080 1.00 43.19 O ATOM 1772 N ILE A 135 −67.708 46.594 11.944 1.00 41.85 N ATOM 1773 CA ILE A 135 −67.216 45.247 12.216 1.00 40.75 C ATOM 1775 CB ILE A 135 −68.183 44.507 13.170 1.00 40.80 C ATOM 1777 CG1 ILE A 135 −68.227 45.226 14.524 1.00 41.21 C ATOM 1780 CD1 ILE A 135 −69.353 46.283 14.633 1.00 42.86 C ATOM 1784 CG2 ILE A 135 −67.776 43.063 13.373 1.00 40.88 C ATOM 1788 C ILE A 135 −66.980 44.457 10.933 1.00 39.67 C ATOM 1789 O ILE A 135 −66.166 43.537 10.901 1.00 39.37 O ATOM 1791 N LYS A 136 −67.690 44.828 9.877 1.00 38.62 N ATOM 1792 CA LYS A 136 −67.465 44.256 8.554 1.00 37.88 C ATOM 1794 CB LYS A 136 −68.525 44.749 7.561 1.00 38.33 C ATOM 1797 CG LYS A 136 −69.955 44.342 7.879 1.00 40.17 C ATOM 1800 CD LYS A 136 −70.486 43.262 6.911 1.00 42.97 C ATOM 1803 CE LYS A 136 −71.624 42.389 7.536 1.00 44.00 C ATOM 1806 NZ LYS A 136 −72.950 43.086 7.726 1.00 43.82 N ATOM 1810 C LYS A 136 −66.097 44.687 8.047 1.00 36.38 C ATOM 1811 O LYS A 136 −65.399 43.914 7.388 1.00 36.24 O ATOM 1813 N ALA A 137 −65.728 45.931 8.341 1.00 34.51 N ATOM 1814 CA ALA A 137 −64.463 46.474 7.876 1.00 33.41 C ATOM 1816 CB ALA A 137 −64.432 47.981 8.058 1.00 33.43 C ATOM 1820 C ALA A 137 −63.291 45.827 8.600 1.00 32.30 C ATOM 1821 O ALA A 137 −62.288 45.481 7.995 1.00 31.89 O ATOM 1823 N ILE A 138 −63.437 45.662 9.905 1.00 31.41 N ATOM 1824 CA ILE A 138 −62.395 45.074 10.737 1.00 30.60 C ATOM 1826 CB ILE A 138 −62.770 45.131 12.238 1.00 30.20 C ATOM 1828 CG1 ILE A 138 −62.914 46.576 12.689 1.00 29.92 C ATOM 1831 CD1 ILE A 138 −61.681 47.414 12.417 1.00 30.50 C ATOM 1835 CG2 ILE A 138 −61.706 44.470 13.085 1.00 29.73 C ATOM 1839 C ILE A 138 −62.140 43.631 10.320 1.00 30.34 C ATOM 1840 O ILE A 138 −60.972 43.203 10.212 1.00 30.65 O ATOM 1842 N LEU A 139 −63.227 42.884 10.098 1.00 29.69 N ATOM 1843 CA LEU A 139 −63.134 41.523 9.562 1.00 29.23 C ATOM 1845 CB LEU A 139 −64.517 40.917 9.332 1.00 28.92 C ATOM 1848 CG LEU A 139 −65.066 40.185 10.545 1.00 29.06 C ATOM 1850 CD1 LEU A 139 −66.541 39.875 10.352 1.00 28.20 C ATOM 1854 CD2 LEU A 139 −64.250 38.922 10.813 1.00 28.59 C ATOM 1858 C LEU A 139 −62.382 41.546 8.247 1.00 29.00 C ATOM 1859 O LEU A 139 −61.444 40.773 8.035 1.00 29.50 O ATOM 1861 N SER A 140 −62.790 42.458 7.372 1.00 28.14 N ATOM 1862 CA SER A 140 −62.222 42.526 6.054 1.00 27.40 C ATOM 1864 CB SER A 140 −62.912 43.619 5.260 1.00 27.35 C ATOM 1867 OG SER A 140 −63.310 43.103 4.015 1.00 28.43 O ATOM 1869 C SER A 140 −60.720 42.777 6.123 1.00 26.77 C ATOM 1870 O SER A 140 −59.975 42.269 5.298 1.00 27.29 O ATOM 1872 N LEU A 141 −60.285 43.563 7.105 1.00 25.89 N ATOM 1873 CA LEU A 141 −58.872 43.897 7.283 1.00 25.20 C ATOM 1875 CB LEU A 141 −58.717 45.164 8.155 1.00 25.00 C ATOM 1878 CG LEU A 141 −57.298 45.670 8.489 1.00 24.35 C ATOM 1880 CD1 LEU A 141 −56.497 45.974 7.232 1.00 22.75 C ATOM 1884 CD2 LEU A 141 −57.329 46.893 9.385 1.00 22.81 C ATOM 1888 C LEU A 141 −58.140 42.721 7.920 1.00 24.92 C ATOM 1889 O LEU A 141 −57.034 42.380 7.521 1.00 24.77 O ATOM 1891 N TYR A 142 −58.751 42.101 8.921 1.00 24.51 N ATOM 1892 CA TYR A 142 −58.163 40.913 9.514 1.00 24.36 C ATOM 1894 CB TYR A 142 −59.120 40.325 10.538 1.00 24.18 C ATOM 1897 CG TYR A 142 −58.774 38.941 11.046 1.00 23.72 C ATOM 1898 CD1 TYR A 142 −57.878 38.763 12.091 1.00 22.97 C ATOM 1900 CE1 TYR A 142 −57.593 37.500 12.582 1.00 24.25 C ATOM 1902 CZ TYR A 142 −58.229 36.386 12.030 1.00 25.75 C ATOM 1903 OH TYR A 142 −57.967 35.100 12.500 1.00 26.97 O ATOM 1905 CE2 TYR A 142 −59.120 36.551 10.988 1.00 25.02 C ATOM 1907 CD2 TYR A 142 −59.390 37.820 10.511 1.00 24.01 C ATOM 1909 C TYR A 142 −57.877 39.896 8.423 1.00 24.39 C ATOM 1910 O TYR A 142 −56.822 39.276 8.380 1.00 24.19 O ATOM 1912 N GLU A 143 −58.841 39.760 7.527 1.00 24.59 N ATOM 1913 CA GLU A 143 −58.820 38.728 6.521 1.00 24.70 C ATOM 1915 CB GLU A 143 −60.194 38.636 5.853 1.00 24.69 C ATOM 1918 CG GLU A 143 −60.651 37.219 5.547 1.00 27.21 C ATOM 1921 CD GLU A 143 −61.127 36.426 6.774 1.00 30.20 C ATOM 1922 OE1 GLU A 143 −60.261 35.776 7.393 1.00 33.40 O ATOM 1923 OE2 GLU A 143 −62.351 36.421 7.097 1.00 30.50 O ATOM 1924 C GLU A 143 −57.701 39.010 5.518 1.00 24.08 C ATOM 1925 O GLU A 143 −56.984 38.090 5.126 1.00 24.53 O ATOM 1927 N ALA A 144 −57.537 40.281 5.147 1.00 23.30 N ATOM 1928 CA ALA A 144 −56.515 40.715 4.173 1.00 22.79 C ATOM 1930 CB ALA A 144 −56.787 42.154 3.740 1.00 22.49 C ATOM 1934 C ALA A 144 −55.073 40.598 4.701 1.00 22.42 C ATOM 1935 O ALA A 144 −54.128 40.380 3.935 1.00 22.36 O ATOM 1937 N SER A 145 −54.909 40.713 6.012 1.00 21.80 N ATOM 1938 CA SER A 145 −53.593 40.822 6.600 1.00 21.36 C ATOM 1940 CB SER A 145 −53.726 41.170 8.066 1.00 21.21 C ATOM 1943 OG SER A 145 −54.337 40.100 8.753 1.00 21.59 O ATOM 1945 C SER A 145 −52.797 39.537 6.476 1.00 21.30 C ATOM 1946 O SER A 145 −51.571 39.533 6.701 1.00 21.50 O ATOM 1948 N PHE A 146 −53.488 38.439 6.154 1.00 21.00 N ATOM 1949 CA PHE A 146 −52.827 37.127 6.030 1.00 20.41 C ATOM 1951 CB PHE A 146 −53.796 35.979 6.338 1.00 20.20 C ATOM 1954 CG PHE A 146 −54.130 35.873 7.798 1.00 19.91 C ATOM 1955 CD1 PHE A 146 −53.382 35.087 8.637 1.00 20.48 C ATOM 1957 CE1 PHE A 146 −53.679 35.012 9.992 1.00 20.59 C ATOM 1959 CZ PHE A 146 −54.731 35.740 10.508 1.00 19.15 C ATOM 1961 CE2 PHE A 146 −55.464 36.536 9.691 1.00 19.10 C ATOM 1963 CD2 PHE A 146 −55.155 36.615 8.343 1.00 20.16 C ATOM 1965 C PHE A 146 −52.174 36.964 4.680 1.00 19.76 C ATOM 1966 O PHE A 146 −51.305 36.116 4.523 1.00 19.46 O ATOM 1968 N LEU A 147 −52.550 37.819 3.729 1.00 19.34 N ATOM 1969 CA LEU A 147 −51.933 37.804 2.402 1.00 19.13 C ATOM 1971 CB LEU A 147 −52.905 38.367 1.347 1.00 18.67 C ATOM 1974 CG LEU A 147 −53.964 37.334 .919 1.00 18.11 C ATOM 1976 CD1 LEU A 147 −55.090 37.248 1.961 1.00 15.10 C ATOM 1980 CD2 LEU A 147 −54.494 37.609 −.499 1.00 16.50 C ATOM 1984 C LEU A 147 −50.582 38.525 2.369 1.00 19.10 C ATOM 1985 O LEU A 147 −49.992 38.715 1.311 1.00 19.44 O ATOM 1987 N ALA A 148 −50.075 38.882 3.542 1.00 19.13 N ATOM 1988 CA ALA A 148 −48.967 39.806 3.664 1.00 18.84 C ATOM 1990 CB ALA A 148 −48.762 40.167 5.117 1.00 18.78 C ATOM 1994 C ALA A 148 −47.723 39.184 3.113 1.00 18.85 C ATOM 1995 O ALA A 148 −47.548 37.975 3.206 1.00 18.80 O ATOM 1997 N LEU A 149 −46.869 40.013 2.523 1.00 19.08 N ATOM 1998 CA LEU A 149 −45.507 39.601 2.215 1.00 19.32 C ATOM 2000 CB LEU A 149 −45.056 40.145 .863 1.00 19.14 C ATOM 2003 CG LEU A 149 −45.819 39.650 −.364 1.00 19.16 C ATOM 2005 CD1 LEU A 149 −45.036 39.929 −1.645 1.00 18.43 C ATOM 2009 CD2 LEU A 149 −46.089 38.175 −.259 1.00 20.09 C ATOM 2013 C LEU A 149 −44.527 40.029 3.304 1.00 19.60 C ATOM 2014 O LEU A 149 −44.797 40.916 4.113 1.00 19.20 O ATOM 2016 N GLU A 150 −43.384 39.361 3.309 1.00 20.42 N ATOM 2017 CA GLU A 150 −42.286 39.674 4.215 1.00 21.03 C ATOM 2019 CB GLU A 150 −41.098 38.741 3.948 1.00 21.03 C ATOM 2022 CG GLU A 150 −40.491 38.176 5.205 1.00 22.23 C ATOM 2025 CD GLU A 150 −39.433 37.117 4.941 1.00 24.34 C ATOM 2026 OE1 GLU A 150 −39.189 36.786 3.753 1.00 24.53 O ATOM 2027 OE2 GLU A 150 −38.843 36.625 5.940 1.00 25.82 O ATOM 2028 C GLU A 150 −41.887 41.130 4.011 1.00 21.29 C ATOM 2029 O GLU A 150 −41.619 41.544 2.885 1.00 21.13 O ATOM 2031 N GLY A 151 −41.893 41.903 5.094 1.00 21.89 N ATOM 2032 CA GLY A 151 −41.636 43.341 5.030 1.00 22.25 C ATOM 2035 C GLY A 151 −42.871 44.221 5.152 1.00 22.67 C ATOM 2036 O GLY A 151 −42.757 45.397 5.462 1.00 22.84 O ATOM 2038 N GLU A 152 −44.055 43.669 4.918 1.00 23.19 N ATOM 2039 CA GLU A 152 −45.263 44.474 4.937 1.00 23.76 C ATOM 2041 CB GLU A 152 −46.350 43.813 4.100 1.00 23.79 C ATOM 2044 CG GLU A 152 −46.037 43.890 2.615 1.00 23.98 C ATOM 2047 CD GLU A 152 −47.147 43.368 1.749 1.00 23.72 C ATOM 2048 OE1 GLU A 152 −47.226 43.771 .574 1.00 22.11 O ATOM 2049 OE2 GLU A 152 −47.939 42.542 2.241 1.00 25.41 O ATOM 2050 C GLU A 152 −45.722 44.719 6.365 1.00 24.47 C ATOM 2051 O GLU A 152 −46.586 44.006 6.906 1.00 24.70 O ATOM 2053 N ASN A 153 −45.134 45.744 6.969 1.00 25.00 N ATOM 2054 CA ASN A 153 −45.287 45.978 8.404 1.00 25.59 C ATOM 2056 CB ASN A 153 −44.221 46.957 8.902 1.00 25.55 C ATOM 2059 CG ASN A 153 −44.386 48.331 8.308 1.00 25.57 C ATOM 2060 OD1 ASN A 153 −44.114 48.557 7.128 1.00 24.52 O ATOM 2061 ND2 ASN A 153 −44.867 49.256 9.117 1.00 27.05 N ATOM 2064 C ASN A 153 −46.679 46.486 8.772 1.00 25.92 C ATOM 2065 O ASN A 153 −47.172 46.238 9.872 1.00 26.02 O ATOM 2067 N ILE A 154 −47.310 47.197 7.847 1.00 26.35 N ATOM 2068 CA ILE A 154 −48.638 47.751 8.082 1.00 26.57 C ATOM 2070 CB ILE A 154 −49.013 48.779 7.007 1.00 26.45 C ATOM 2072 CG1 ILE A 154 −48.159 50.023 7.164 1.00 26.36 C ATOM 2075 CD1 ILE A 154 −48.060 50.790 5.883 1.00 27.92 C ATOM 2079 CG2 ILE A 154 −50.467 49.152 7.089 1.00 26.25 C ATOM 2083 C ILE A 154 −49.674 46.643 8.111 1.00 26.96 C ATOM 2084 O ILE A 154 −50.650 46.741 8.851 1.00 27.12 O ATOM 2086 N LEU A 155 −49.467 45.588 7.320 1.00 27.35 N ATOM 2087 CA LEU A 155 −50.422 44.475 7.304 1.00 27.76 C ATOM 2089 CB LEU A 155 −50.238 43.594 6.067 1.00 27.73 C ATOM 2092 CG LEU A 155 −51.090 43.990 4.875 1.00 27.31 C ATOM 2094 CD1 LEU A 155 −50.980 45.456 4.683 1.00 28.13 C ATOM 2098 CD2 LEU A 155 −50.633 43.262 3.623 1.00 27.79 C ATOM 2102 C LEU A 155 −50.340 43.642 8.582 1.00 28.22 C ATOM 2103 O LEU A 155 −51.361 43.237 9.112 1.00 27.95 O ATOM 2105 N ASP A 156 −49.128 43.395 9.068 1.00 28.95 N ATOM 2106 CA ASP A 156 −48.944 42.723 10.348 1.00 29.71 C ATOM 2108 CB ASP A 156 −47.450 42.461 10.639 1.00 30.23 C ATOM 2111 CG ASP A 156 −46.938 41.125 10.027 1.00 32.82 C ATOM 2112 OD1 ASP A 156 −47.765 40.240 9.658 1.00 36.27 O ATOM 2113 OD2 ASP A 156 −45.700 40.961 9.923 1.00 34.48 O ATOM 2114 C ASP A 156 −49.570 43.539 11.469 1.00 29.66 C ATOM 2115 O ASP A 156 −50.109 42.969 12.425 1.00 29.81 O ATOM 2117 N GLU A 157 −49.514 44.866 11.345 1.00 29.69 N ATOM 2118 CA GLU A 157 −50.129 45.768 12.329 1.00 29.57 C ATOM 2120 CB GLU A 157 −49.581 47.186 12.178 1.00 29.71 C ATOM 2123 CG GLU A 157 −48.164 47.326 12.712 1.00 30.53 C ATOM 2126 CD GLU A 157 −47.455 48.544 12.169 1.00 31.96 C ATOM 2127 OE1 GLU A 157 −48.167 49.491 11.741 1.00 33.56 O ATOM 2128 OE2 GLU A 157 −46.195 48.546 12.166 1.00 31.54 O ATOM 2129 C GLU A 157 −51.649 45.771 12.230 1.00 29.16 C ATOM 2130 O GLU A 157 −52.330 45.819 13.241 1.00 29.00 O ATOM 2132 N ALA A 158 −52.172 45.716 11.010 1.00 28.86 N ATOM 2133 CA ALA A 158 −53.606 45.570 10.792 1.00 28.79 C ATOM 2135 CB ALA A 158 −53.893 45.456 9.301 1.00 28.44 C ATOM 2139 C ALA A 158 −54.171 44.352 11.536 1.00 28.93 C ATOM 2140 O ALA A 158 −55.265 44.402 12.098 1.00 28.77 O ATOM 2142 N LYS A 159 −53.416 43.260 11.528 1.00 29.19 N ATOM 2143 CA LYS A 159 −53.849 42.022 12.143 1.00 29.57 C ATOM 2145 CB LYS A 159 −52.929 40.880 11.710 1.00 29.62 C ATOM 2148 CG LYS A 159 −53.297 39.513 12.258 1.00 30.27 C ATOM 2151 CD LYS A 159 −52.765 38.365 11.387 1.00 31.78 C ATOM 2154 CE LYS A 159 −51.259 38.132 11.525 1.00 33.15 C ATOM 2157 NZ LYS A 159 −50.911 36.696 11.248 1.00 33.88 N ATOM 2161 C LYS A 159 −53.866 42.160 13.670 1.00 29.99 C ATOM 2162 O LYS A 159 −54.767 41.642 14.332 1.00 30.29 O ATOM 2164 N VAL A 160 −52.886 42.862 14.236 1.00 30.07 N ATOM 2165 CA VAL A 160 −52.840 43.047 15.696 1.00 30.03 C ATOM 2167 CB VAL A 160 −51.520 43.691 16.162 1.00 29.88 C ATOM 2169 CG1 VAL A 160 −51.515 43.863 17.671 1.00 28.94 C ATOM 2173 CG2 VAL A 160 −50.341 42.848 15.707 1.00 30.23 C ATOM 2177 C VAL A 160 −53.996 43.925 16.149 1.00 30.05 C ATOM 2178 O VAL A 160 −54.544 43.752 17.234 1.00 30.31 O ATOM 2180 N PHE A 161 −54.355 44.862 15.290 1.00 30.08 N ATOM 2181 CA PHE A 161 −55.407 45.808 15.558 1.00 30.09 C ATOM 2183 CB PHE A 161 −55.255 46.993 14.598 1.00 29.92 C ATOM 2186 CG PHE A 161 −56.370 47.974 14.654 1.00 28.52 C ATOM 2187 CD1 PHE A 161 −56.347 49.005 15.554 1.00 27.92 C ATOM 2189 CE1 PHE A 161 −57.361 49.903 15.600 1.00 28.06 C ATOM 2191 CZ PHE A 161 −58.411 49.783 14.733 1.00 28.76 C ATOM 2193 CE2 PHE A 161 −58.441 48.757 13.826 1.00 28.31 C ATOM 2195 CD2 PHE A 161 −57.429 47.869 13.789 1.00 28.16 C ATOM 2197 C PHE A 161 −56.746 45.123 15.388 1.00 30.55 C ATOM 2198 O PHE A 161 −57.598 45.203 16.258 1.00 30.53 O ATOM 2200 N ALA A 162 −56.930 44.438 14.271 1.00 31.34 N ATOM 2201 CA ALA A 162 −58.193 43.770 14.023 1.00 32.26 C ATOM 2203 CB ALA A 162 −58.217 43.139 12.643 1.00 32.31 C ATOM 2207 C ALA A 162 −58.500 42.734 15.118 1.00 33.09 C ATOM 2208 O ALA A 162 −59.557 42.814 15.735 1.00 33.83 O ATOM 2210 N ILE A 163 −57.587 41.799 15.393 1.00 33.59 N ATOM 2211 CA ILE A 163 −57.826 40.799 16.438 1.00 34.02 C ATOM 2213 CB ILE A 163 −56.597 39.907 16.745 1.00 33.98 C ATOM 2215 CG1 ILE A 163 −56.235 39.008 15.566 1.00 34.37 C ATOM 2218 CD1 ILE A 163 −54.878 38.317 15.722 1.00 34.38 C ATOM 2222 CG2 ILE A 163 −56.883 38.995 17.919 1.00 33.38 C ATOM 2226 C ILE A 163 −58.225 41.472 17.744 1.00 34.75 C ATOM 2227 O ILE A 163 −59.189 41.064 18.373 1.00 35.03 O ATOM 2229 N SER A 164 −57.501 42.504 18.156 1.00 35.76 N ATOM 2230 CA SER A 164 −57.763 43.117 19.463 1.00 36.59 C ATOM 2232 CB SER A 164 −56.828 44.293 19.735 1.00 36.59 C ATOM 2235 OG SER A 164 −57.350 45.485 19.164 1.00 36.46 O ATOM 2237 C SER A 164 −59.196 43.611 19.556 1.00 37.42 C ATOM 2238 O SER A 164 −59.860 43.420 20.571 1.00 37.38 O ATOM 2240 N HIS A 165 −59.661 44.251 18.486 1.00 38.51 N ATOM 2241 CA HIS A 165 −60.990 44.851 18.467 1.00 39.40 C ATOM 2243 CB HIS A 165 −61.008 46.097 17.574 1.00 39.76 C ATOM 2246 CG HIS A 165 −60.467 47.323 18.251 1.00 42.06 C ATOM 2247 ND1 HIS A 165 −59.205 47.821 18.000 1.00 44.21 N ATOM 2249 CE1 HIS A 165 −58.998 48.893 18.748 1.00 45.04 C ATOM 2251 NE2 HIS A 165 −60.080 49.106 19.478 1.00 44.99 N ATOM 2253 CD2 HIS A 165 −61.011 48.135 19.192 1.00 43.76 C ATOM 2255 C HIS A 165 −62.078 43.872 18.060 1.00 39.38 C ATOM 2256 O HIS A 165 −63.248 44.244 18.067 1.00 39.43 O ATOM 2258 N LEU A 166 −61.683 42.632 17.745 1.00 39.54 N ATOM 2259 CA LEU A 166 −62.589 41.550 17.326 1.00 39.55 C ATOM 2261 CB LEU A 166 −62.001 40.766 16.154 1.00 39.28 C ATOM 2264 CG LEU A 166 −62.156 41.339 14.752 1.00 38.23 C ATOM 2266 CD1 LEU A 166 −61.361 40.501 13.805 1.00 37.53 C ATOM 2270 CD2 LEU A 166 −63.594 41.367 14.332 1.00 37.21 C ATOM 2274 C LEU A 166 −62.842 40.555 18.438 1.00 40.08 C ATOM 2275 O LEU A 166 −63.991 40.220 18.733 1.00 40.42 O ATOM 2277 N LYS A 167 −61.766 40.074 19.052 1.00 40.58 N ATOM 2278 CA LYS A 167 −61.875 39.090 20.133 1.00 41.09 C ATOM 2280 CB LYS A 167 −60.491 38.632 20.595 1.00 41.13 C ATOM 2283 CG LYS A 167 −59.897 39.399 21.768 1.00 42.16 C ATOM 2286 CD LYS A 167 −58.421 39.035 22.013 1.00 44.45 C ATOM 2289 CE LYS A 167 −58.070 37.561 21.654 1.00 45.56 C ATOM 2292 NZ LYS A 167 −56.610 37.237 21.798 1.00 46.20 N ATOM 2296 C LYS A 167 −62.678 39.584 21.337 1.00 41.23 C ATOM 2297 O LYS A 167 −62.994 38.793 22.215 1.00 41.47 O ATOM 2299 N GLU A 168 −62.995 40.884 21.352 1.00 41.49 N ATOM 2300 CA GLU A 168 −63.704 41.583 22.437 1.00 41.42 C ATOM 2302 CB GLU A 168 −65.201 41.730 22.100 1.00 41.27 C ATOM 2305 CG GLU A 168 −65.995 40.424 22.016 1.00 41.01 C ATOM 2308 CD GLU A 168 −66.928 40.328 20.787 1.00 40.84 C ATOM 2309 OE1 GLU A 168 −66.701 41.040 19.770 1.00 39.82 O ATOM 2310 OE2 GLU A 168 −67.884 39.509 20.845 1.00 39.04 O ATOM 2311 C GLU A 168 −63.484 41.004 23.843 1.00 41.66 C ATOM 2312 O GLU A 168 −62.435 41.231 24.469 1.00 41.46 O ATOM 2314 N GLU A 172 −71.668 38.961 21.192 1.00 55.65 N ATOM 2315 CA GLU A 172 −73.052 39.153 20.721 1.00 56.00 C ATOM 2317 CB GLU A 172 −73.876 37.880 20.937 1.00 56.27 C ATOM 2320 CG GLU A 172 −73.198 36.620 20.390 1.00 57.12 C ATOM 2323 CD GLU A 172 −74.056 35.363 20.516 1.00 58.18 C ATOM 2324 OE1 GLU A 172 −75.300 35.480 20.622 1.00 58.84 O ATOM 2325 OE2 GLU A 172 −73.480 34.249 20.498 1.00 58.98 O ATOM 2326 C GLU A 172 −73.766 40.386 21.334 1.00 55.70 C ATOM 2327 O GLU A 172 −74.956 40.347 21.688 1.00 54.95 O ATOM 2329 N LYS A 173 −72.987 41.458 21.486 1.00 55.58 N ATOM 2330 CA LYS A 173 −73.496 42.831 21.466 1.00 55.43 C ATOM 2332 CB LYS A 173 −72.649 43.741 22.357 1.00 55.51 C ATOM 2335 CG LYS A 173 −72.527 43.223 23.793 1.00 56.07 C ATOM 2338 CD LYS A 173 −72.803 44.291 24.868 1.00 55.87 C ATOM 2341 CE LYS A 173 −73.111 43.642 26.221 1.00 55.20 C ATOM 2344 NZ LYS A 173 −72.893 44.576 27.348 1.00 54.63 N ATOM 2348 C LYS A 173 −73.449 43.297 20.009 1.00 55.01 C ATOM 2349 O LYS A 173 −74.091 44.274 19.625 1.00 54.97 O ATOM 2351 N ILE A 174 −72.647 42.581 19.223 1.00 54.57 N ATOM 2352 CA ILE A 174 −72.713 42.550 17.767 1.00 54.22 C ATOM 2354 CB ILE A 174 −71.429 41.845 17.227 1.00 54.21 C ATOM 2356 CG1 ILE A 174 −70.196 42.724 17.474 1.00 54.73 C ATOM 2359 CD1 ILE A 174 −68.858 41.949 17.553 1.00 55.78 C ATOM 2363 CG2 ILE A 174 −71.532 41.504 15.759 1.00 54.06 C ATOM 2367 C ILE A 174 −73.957 41.744 17.384 1.00 53.88 C ATOM 2368 O ILE A 174 −74.587 41.134 18.250 1.00 53.83 O ATOM 2370 N GLY A 175 −74.332 41.747 16.107 1.00 53.59 N ATOM 2371 CA GLY A 175 −75.351 40.817 15.613 1.00 53.51 C ATOM 2374 C GLY A 175 −75.130 39.395 16.126 1.00 53.43 C ATOM 2375 O GLY A 175 −74.119 39.105 16.760 1.00 53.80 O ATOM 2377 N LYS A 176 −76.070 38.495 15.861 1.00 53.10 N ATOM 2378 CA LYS A 176 −75.926 37.098 16.286 1.00 52.68 C ATOM 2380 CB LYS A 176 −77.291 36.522 16.677 1.00 52.99 C ATOM 2383 CG LYS A 176 −78.003 37.387 17.746 1.00 54.12 C ATOM 2386 CD LYS A 176 −79.201 36.697 18.436 1.00 54.57 C ATOM 2389 CE LYS A 176 −79.503 37.369 19.792 1.00 54.79 C ATOM 2392 NZ LYS A 176 −80.458 36.598 20.653 1.00 55.20 N ATOM 2396 C LYS A 176 −75.246 36.267 15.196 1.00 51.83 C ATOM 2397 O LYS A 176 −74.393 35.433 15.486 1.00 51.69 O ATOM 2399 N GLU A 177 −75.609 36.520 13.940 1.00 50.90 N ATOM 2400 CA GLU A 177 −74.975 35.854 12.800 1.00 50.19 C ATOM 2402 CB GLU A 177 −75.792 36.062 11.507 1.00 50.41 C ATOM 2405 CG GLU A 177 −75.506 37.368 10.735 1.00 51.03 C ATOM 2408 CD GLU A 177 −76.403 37.572 9.507 1.00 52.17 C ATOM 2409 OE1 GLU A 177 −75.955 38.276 8.569 1.00 52.63 O ATOM 2410 OE2 GLU A 177 −77.546 37.048 9.479 1.00 52.03 O ATOM 2411 C GLU A 177 −73.549 36.369 12.607 1.00 49.10 C ATOM 2412 O GLU A 177 −72.626 35.597 12.321 1.00 49.53 O ATOM 2414 N LEU A 178 −73.388 37.681 12.770 1.00 47.39 N ATOM 2415 CA LEU A 178 −72.110 38.371 12.575 1.00 45.63 C ATOM 2417 CB LEU A 178 −72.352 39.877 12.615 1.00 45.59 C ATOM 2420 CG LEU A 178 −71.280 40.809 12.085 1.00 45.45 C ATOM 2422 CD1 LEU A 178 −70.969 40.515 10.620 1.00 45.45 C ATOM 2426 CD2 LEU A 178 −71.765 42.233 12.279 1.00 44.63 C ATOM 2430 C LEU A 178 −71.095 37.979 13.634 1.00 44.06 C ATOM 2431 O LEU A 178 −69.902 38.012 13.387 1.00 43.70 O ATOM 2433 N ALA A 179 −71.586 37.611 14.810 1.00 42.54 N ATOM 2434 CA ALA A 179 −70.753 37.041 15.847 1.00 41.66 C ATOM 2436 CB ALA A 179 −71.545 36.884 17.122 1.00 41.69 C ATOM 2440 C ALA A 179 −70.193 35.695 15.416 1.00 40.75 C ATOM 2441 O ALA A 179 −69.078 35.351 15.769 1.00 40.61 O ATOM 2443 N GLU A 180 −70.974 34.931 14.664 1.00 39.88 N ATOM 2444 CA GLU A 180 −70.518 33.639 14.143 1.00 39.40 C ATOM 2446 CB GLU A 180 −71.710 32.781 13.718 1.00 39.74 C ATOM 2449 CG GLU A 180 −72.650 32.415 14.865 1.00 40.88 C ATOM 2452 CD GLU A 180 −73.913 31.710 14.398 1.00 42.02 C ATOM 2453 OE1 GLU A 180 −74.380 32.022 13.271 1.00 43.05 O ATOM 2454 OE2 GLU A 180 −74.437 30.857 15.166 1.00 41.93 O ATOM 2455 C GLU A 180 −69.565 33.805 12.960 1.00 38.29 C ATOM 2456 O GLU A 180 −68.739 32.940 12.699 1.00 38.23 O ATOM 2458 N GLN A 181 −69.704 34.911 12.240 1.00 36.92 N ATOM 2459 CA GLN A 181 −68.748 35.299 11.223 1.00 35.74 C ATOM 2461 CB GLN A 181 −69.272 36.516 10.463 1.00 35.94 C ATOM 2464 CG GLN A 181 −68.931 36.537 8.975 1.00 36.93 C ATOM 2467 CD GLN A 181 −69.693 35.492 8.176 1.00 37.72 C ATOM 2468 OE1 GLN A 181 −70.769 35.067 8.567 1.00 38.78 O ATOM 2469 NE2 GLN A 181 −69.139 35.083 7.050 1.00 38.11 N ATOM 2472 C GLN A 181 −67.406 35.632 11.881 1.00 34.64 C ATOM 2473 O GLN A 181 −66.348 35.411 11.294 1.00 34.73 O ATOM 2475 N VAL A 182 −67.448 36.158 13.102 1.00 33.29 N ATOM 2476 CA VAL A 182 −66.224 36.488 13.842 1.00 32.28 C ATOM 2478 CB VAL A 182 −66.433 37.653 14.855 1.00 32.10 C ATOM 2480 CG1 VAL A 182 −66.328 38.991 14.166 1.00 31.51 C ATOM 2484 CG2 VAL A 182 −65.420 37.594 15.957 1.00 31.69 C ATOM 2488 C VAL A 182 −65.613 35.298 14.575 1.00 31.49 C ATOM 2489 O VAL A 182 −64.396 35.230 14.668 1.00 31.43 O ATOM 2491 N SER A 183 −66.422 34.378 15.106 1.00 30.56 N ATOM 2492 CA SER A 183 −65.860 33.174 15.744 1.00 30.16 C ATOM 2494 CB SER A 183 −66.926 32.253 16.327 1.00 30.29 C ATOM 2497 OG SER A 183 −67.796 32.934 17.214 1.00 32.35 O ATOM 2499 C SER A 183 −65.111 32.403 14.692 1.00 29.30 C ATOM 2500 O SER A 183 −63.974 31.981 14.903 1.00 29.32 O ATOM 2502 N HIS A 184 −65.768 32.252 13.546 1.00 28.24 N ATOM 2503 CA HIS A 184 −65.215 31.578 12.379 1.00 27.36 C ATOM 2505 CB HIS A 184 −66.245 31.653 11.254 1.00 27.41 C ATOM 2508 CG HIS A 184 −65.930 30.807 10.064 1.00 26.90 C ATOM 2509 ND1 HIS A 184 −65.484 29.511 10.166 1.00 27.76 N ATOM 2511 CE1 HIS A 184 −65.321 29.009 8.955 1.00 27.47 C ATOM 2513 NE2 HIS A 184 −65.661 29.929 8.075 1.00 26.52 N ATOM 2515 CD2 HIS A 184 −66.059 31.058 8.742 1.00 26.61 C ATOM 2517 C HIS A 184 −63.898 32.200 11.940 1.00 26.69 C ATOM 2518 O HIS A 184 −62.881 31.525 11.862 1.00 26.44 O ATOM 2520 N ALA A 185 −63.909 33.498 11.675 1.00 26.11 N ATOM 2521 CA ALA A 185 −62.711 34.176 11.205 1.00 25.63 C ATOM 2523 CB ALA A 185 −62.970 35.627 11.109 1.00 25.74 C ATOM 2527 C ALA A 185 −61.552 33.917 12.153 1.00 25.33 C ATOM 2528 O ALA A 185 −60.451 33.572 11.725 1.00 25.79 O ATOM 2530 N LEU A 186 −61.814 34.066 13.450 1.00 24.77 N ATOM 2531 CA LEU A 186 −60.776 33.940 14.470 1.00 24.05 C ATOM 2533 CB LEU A 186 −61.256 34.498 15.814 1.00 23.63 C ATOM 2536 CG LEU A 186 −61.516 36.012 15.903 1.00 22.51 C ATOM 2538 CD1 LEU A 186 −62.057 36.399 17.266 1.00 20.79 C ATOM 2542 CD2 LEU A 186 −60.273 36.793 15.613 1.00 21.13 C ATOM 2546 C LEU A 186 −60.316 32.497 14.613 1.00 24.02 C ATOM 2547 O LEU A 186 −59.169 32.250 14.943 1.00 24.27 O ATOM 2549 N GLU A 187 −61.201 31.543 14.347 1.00 23.88 N ATOM 2550 CA GLU A 187 −60.836 30.117 14.348 1.00 23.53 C ATOM 2552 CB GLU A 187 −62.029 29.270 13.919 1.00 23.66 C ATOM 2555 CG GLU A 187 −61.945 27.828 14.316 1.00 25.26 C ATOM 2558 CD GLU A 187 −63.049 26.971 13.693 1.00 28.04 C ATOM 2559 OE1 GLU A 187 −63.672 27.393 12.681 1.00 28.67 O ATOM 2560 OE2 GLU A 187 −63.288 25.858 14.225 1.00 29.72 O ATOM 2561 C GLU A 187 −59.686 29.838 13.395 1.00 22.92 C ATOM 2562 O GLU A 187 −58.765 29.091 13.729 1.00 22.53 O ATOM 2564 N LEU A 188 −59.763 30.446 12.209 1.00 22.46 N ATOM 2565 CA LEU A 188 −58.799 30.246 11.121 1.00 22.07 C ATOM 2567 CB LEU A 188 −58.802 28.794 10.635 1.00 22.11 C ATOM 2570 CG LEU A 188 −57.876 28.362 9.493 1.00 22.17 C ATOM 2572 CD1 LEU A 188 −56.456 28.051 9.961 1.00 21.62 C ATOM 2576 CD2 LEU A 188 −58.464 27.134 8.822 1.00 22.40 C ATOM 2580 C LEU A 188 −59.237 31.137 9.985 1.00 21.69 C ATOM 2581 O LEU A 188 −60.380 31.075 9.563 1.00 21.53 O ATOM 2583 N PRO A 189 −58.333 31.973 9.474 1.00 21.46 N ATOM 2584 CA PRO A 189 −58.745 32.935 8.472 1.00 21.18 C ATOM 2586 CB PRO A 189 −57.592 33.936 8.486 1.00 21.03 C ATOM 2589 CG PRO A 189 −56.423 33.118 8.757 1.00 21.21 C ATOM 2592 CD PRO A 189 −56.873 31.992 9.668 1.00 21.61 C ATOM 2595 C PRO A 189 −58.946 32.314 7.076 1.00 20.96 C ATOM 2596 O PRO A 189 −58.418 31.247 6.793 1.00 21.02 O ATOM 2597 N LEU A 190 −59.714 32.994 6.226 1.00 20.89 N ATOM 2598 CA LEU A 190 −60.018 32.533 4.867 1.00 20.74 C ATOM 2600 CB LEU A 190 −60.597 33.690 4.053 1.00 20.76 C ATOM 2603 CG LEU A 190 −62.090 33.924 4.259 1.00 21.35 C ATOM 2605 CD1 LEU A 190 −62.537 35.196 3.578 1.00 20.54 C ATOM 2609 CD2 LEU A 190 −62.889 32.712 3.720 1.00 23.39 C ATOM 2613 C LEU A 190 −58.814 31.971 4.112 1.00 20.35 C ATOM 2614 O LEU A 190 −58.859 30.871 3.546 1.00 20.08 O ATOM 2616 N HIS A 191 −57.734 32.746 4.132 1.00 19.81 N ATOM 2617 CA HIS A 191 −56.537 32.448 3.364 1.00 18.89 C ATOM 2619 CB HIS A 191 −55.548 33.592 3.536 1.00 18.92 C ATOM 2622 CG HIS A 191 −54.372 33.520 2.623 1.00 18.51 C ATOM 2623 ND1 HIS A 191 −54.482 33.647 1.258 1.00 18.08 N ATOM 2625 CE1 HIS A 191 −53.281 33.544 .718 1.00 18.96 C ATOM 2627 NE2 HIS A 191 −52.397 33.371 1.684 1.00 17.01 N ATOM 2629 CD2 HIS A 191 −53.054 33.355 2.884 1.00 17.94 C ATOM 2631 C HIS A 191 −55.889 31.142 3.759 1.00 18.32 C ATOM 2632 O HIS A 191 −55.217 30.531 2.942 1.00 17.98 O ATOM 2634 N ARG A 192 −56.093 30.719 5.006 1.00 18.06 N ATOM 2635 CA ARG A 192 −55.502 29.480 5.523 1.00 17.99 C ATOM 2637 CB ARG A 192 −54.940 29.722 6.909 1.00 17.77 C ATOM 2640 CG ARG A 192 −53.822 30.683 6.881 1.00 18.47 C ATOM 2643 CD ARG A 192 −53.082 30.748 8.196 1.00 19.80 C ATOM 2646 NE ARG A 192 −52.174 31.900 8.224 1.00 20.33 N ATOM 2648 CZ ARG A 192 −51.176 32.048 9.077 1.00 20.10 C ATOM 2649 NH1 ARG A 192 −50.928 31.113 9.972 1.00 21.72 N ATOM 2652 NH2 ARG A 192 −50.407 33.119 9.019 1.00 20.79 N ATOM 2655 C ARG A 192 −56.477 28.311 5.590 1.00 18.00 C ATOM 2656 O ARG A 192 −56.067 27.170 5.871 1.00 18.21 O ATOM 2658 N ARG A 193 −57.758 28.588 5.335 1.00 17.59 N ATOM 2659 CA ARG A 193 −58.779 27.563 5.382 1.00 17.16 C ATOM 2661 CB ARG A 193 −60.141 28.164 5.741 1.00 17.45 C ATOM 2664 CG ARG A 193 −61.109 27.132 6.322 1.00 18.70 C ATOM 2667 CD ARG A 193 −62.479 27.682 6.686 1.00 20.20 C ATOM 2670 NE ARG A 193 −62.423 28.682 7.751 1.00 22.59 N ATOM 2672 CZ ARG A 193 −62.386 28.435 9.067 1.00 24.12 C ATOM 2673 NH1 ARG A 193 −62.395 27.198 9.575 1.00 22.66 N ATOM 2676 NH2 ARG A 193 −62.348 29.469 9.898 1.00 26.36 N ATOM 2679 C ARG A 193 −58.871 26.842 4.058 1.00 16.63 C ATOM 2680 O ARG A 193 −58.861 27.461 3.005 1.00 15.93 O ATOM 2682 N THR A 194 −58.955 25.518 4.149 1.00 16.72 N ATOM 2683 CA THR A 194 −59.332 24.638 3.051 1.00 16.88 C ATOM 2685 CB THR A 194 −59.520 23.250 3.592 1.00 16.43 C ATOM 2687 OG1 THR A 194 −58.252 22.605 3.583 1.00 17.74 O ATOM 2689 CG2 THR A 194 −60.454 22.441 2.754 1.00 18.43 C ATOM 2693 C THR A 194 −60.607 25.112 2.384 1.00 17.28 C ATOM 2694 O THR A 194 −61.441 25.734 3.022 1.00 17.44 O ATOM 2696 N GLN A 195 −60.765 24.855 1.091 1.00 18.05 N ATOM 2697 CA GLN A 195 −61.925 25.402 .397 1.00 18.76 C ATOM 2699 CB GLN A 195 −61.768 25.381 −1.114 1.00 18.87 C ATOM 2702 CG GLN A 195 −63.145 25.523 −1.761 1.00 20.75 C ATOM 2705 CD GLN A 195 −63.095 25.922 −3.179 1.00 23.41 C ATOM 2706 OE1 GLN A 195 −62.031 26.088 −3.733 1.00 27.07 O ATOM 2707 NE2 GLN A 195 −64.248 26.090 −3.791 1.00 25.02 N ATOM 2710 C GLN A 195 −63.243 24.704 .765 1.00 18.93 C ATOM 2711 O GLN A 195 −64.169 25.333 1.291 1.00 19.42 O ATOM 2713 N ARG A 196 −63.345 23.418 .443 1.00 18.90 N ATOM 2714 CA ARG A 196 −64.577 22.685 .663 1.00 18.68 C ATOM 2716 CB ARG A 196 −64.356 21.186 .454 1.00 18.53 C ATOM 2719 CG ARG A 196 −64.851 20.644 −.888 1.00 18.31 C ATOM 2722 CD ARG A 196 −64.705 21.622 −2.037 1.00 17.93 C ATOM 2725 NE ARG A 196 −65.930 21.720 −2.834 1.00 18.52 N ATOM 2727 CZ ARG A 196 −66.480 22.857 −3.256 1.00 18.63 C ATOM 2728 NH1 ARG A 196 −65.938 24.014 −2.937 1.00 19.84 N ATOM 2731 NH2 ARG A 196 −67.582 22.844 −3.999 1.00 18.53 N ATOM 2734 C ARG A 196 −65.070 22.982 2.061 1.00 19.02 C ATOM 2735 O ARG A 196 −66.276 23.085 2.284 1.00 19.30 O ATOM 2737 N LEU A 197 −64.127 23.152 2.990 1.00 19.09 N ATOM 2738 CA LEU A 197 −64.444 23.432 4.379 1.00 19.19 C ATOM 2740 CB LEU A 197 −63.203 23.346 5.262 1.00 19.14 C ATOM 2743 CG LEU A 197 −63.135 22.097 6.130 1.00 19.99 C ATOM 2745 CD1 LEU A 197 −64.476 21.899 6.811 1.00 21.56 C ATOM 2749 CD2 LEU A 197 −62.016 22.198 7.161 1.00 20.06 C ATOM 2753 C LEU A 197 −65.071 24.781 4.553 1.00 19.52 C ATOM 2754 O LEU A 197 −66.052 24.902 5.252 1.00 19.85 O ATOM 2756 N GLU A 198 −64.488 25.803 3.941 1.00 20.11 N ATOM 2757 CA GLU A 198 −65.051 27.147 3.986 1.00 20.47 C ATOM 2759 CB GLU A 198 −64.079 28.156 3.385 1.00 20.84 C ATOM 2762 CG GLU A 198 −64.659 29.539 3.069 1.00 22.30 C ATOM 2765 CD GLU A 198 −65.206 30.260 4.283 1.00 24.40 C ATOM 2766 OE1 GLU A 198 −64.852 29.894 5.418 1.00 25.34 O ATOM 2767 OE2 GLU A 198 −65.991 31.217 4.106 1.00 26.83 O ATOM 2768 C GLU A 198 −66.360 27.186 3.226 1.00 20.57 C ATOM 2769 O GLU A 198 −67.212 28.009 3.529 1.00 20.65 O ATOM 2771 N ALA A 199 −66.519 26.298 2.240 1.00 20.76 N ATOM 2772 CA ALA A 199 −67.751 26.229 1.452 1.00 20.52 C ATOM 2774 CB ALA A 199 −67.521 25.492 .166 1.00 20.44 C ATOM 2778 C ALA A 199 −68.907 25.611 2.232 1.00 20.55 C ATOM 2779 O ALA A 199 −69.988 26.158 2.202 1.00 20.17 O ATOM 2781 N VAL A 200 −68.701 24.493 2.933 1.00 21.10 N ATOM 2782 CA VAL A 200 −69.791 23.935 3.774 1.00 21.51 C ATOM 2784 CB VAL A 200 −69.509 22.576 4.485 1.00 21.18 C ATOM 2786 CG1 VAL A 200 −69.618 21.460 3.525 1.00 21.27 C ATOM 2790 CG2 VAL A 200 −68.161 22.569 5.200 1.00 21.23 C ATOM 2794 C VAL A 200 −70.170 24.905 4.860 1.00 21.99 C ATOM 2795 O VAL A 200 −71.338 25.022 5.186 1.00 22.99 O ATOM 2797 N TRP A 201 −69.204 25.590 5.440 1.00 22.10 N ATOM 2798 CA TRP A 201 −69.551 26.565 6.433 1.00 22.58 C ATOM 2800 CB TRP A 201 −68.315 27.144 7.121 1.00 22.92 C ATOM 2803 CG TRP A 201 −68.667 27.957 8.310 1.00 23.65 C ATOM 2804 CD1 TRP A 201 −68.758 27.520 9.588 1.00 25.08 C ATOM 2806 NE1 TRP A 201 −69.127 28.549 10.417 1.00 26.35 N ATOM 2808 CE2 TRP A 201 −69.290 29.683 9.669 1.00 25.48 C ATOM 2809 CD2 TRP A 201 −69.010 29.344 8.332 1.00 24.77 C ATOM 2810 CE3 TRP A 201 −69.095 30.336 7.355 1.00 24.92 C ATOM 2812 CZ3 TRP A 201 −69.450 31.616 7.739 1.00 24.96 C ATOM 2814 CH2 TRP A 201 −69.720 31.918 9.078 1.00 25.08 C ATOM 2816 CZ2 TRP A 201 −69.648 30.968 10.056 1.00 24.68 C ATOM 2818 C TRP A 201 −70.351 27.662 5.758 1.00 22.71 C ATOM 2819 O TRP A 201 −71.482 27.921 6.140 1.00 22.76 O ATOM 2821 N SER A 202 −69.776 28.272 4.727 1.00 23.04 N ATOM 2822 CA SER A 202 −70.335 29.500 4.165 1.00 23.29 C ATOM 2824 CB SER A 202 −69.304 30.205 3.290 1.00 23.20 C ATOM 2827 OG SER A 202 −68.306 30.807 4.111 1.00 23.07 O ATOM 2829 C SER A 202 −71.666 29.341 3.432 1.00 23.66 C ATOM 2830 O SER A 202 −72.392 30.310 3.265 1.00 23.38 O ATOM 2832 N ILE A 203 −71.996 28.124 3.016 1.00 24.49 N ATOM 2833 CA ILE A 203 −73.321 27.859 2.460 1.00 25.07 C ATOM 2835 CB ILE A 203 −73.391 26.530 1.653 1.00 24.74 C ATOM 2837 CG1 ILE A 203 −72.494 26.587 .423 1.00 24.36 C ATOM 2840 CD1 ILE A 203 −72.344 25.255 −.281 1.00 23.81 C ATOM 2844 CG2 ILE A 203 −74.795 26.292 1.156 1.00 24.45 C ATOM 2848 C ILE A 203 −74.338 27.858 3.607 1.00 25.91 C ATOM 2849 O ILE A 203 −75.350 28.554 3.546 1.00 26.26 O ATOM 2851 N GLU A 204 −74.051 27.104 4.662 1.00 26.69 N ATOM 2852 CA GLU A 204 −74.929 27.053 5.824 1.00 27.40 C ATOM 2854 CB GLU A 204 −74.286 26.217 6.931 1.00 27.65 C ATOM 2857 CG GLU A 204 −75.132 26.032 8.183 1.00 29.02 C ATOM 2860 CD GLU A 204 −76.530 25.491 7.903 1.00 30.44 C ATOM 2861 OE1 GLU A 204 −76.746 24.858 6.844 1.00 31.22 O ATOM 2862 OE2 GLU A 204 −77.417 25.703 8.753 1.00 31.96 O ATOM 2863 C GLU A 204 −75.258 28.451 6.342 1.00 27.61 C ATOM 2864 O GLU A 204 −76.409 28.778 6.526 1.00 27.78 O ATOM 2866 N ALA A 205 −74.240 29.274 6.547 1.00 28.15 N ATOM 2867 CA ALA A 205 −74.416 30.637 7.050 1.00 28.41 C ATOM 2869 CB ALA A 205 −73.062 31.285 7.274 1.00 28.41 C ATOM 2873 C ALA A 205 −75.234 31.520 6.136 1.00 28.84 C ATOM 2874 O ALA A 205 −76.050 32.302 6.610 1.00 28.54 O ATOM 2876 N TYR A 206 −74.978 31.408 4.832 1.00 29.84 N ATOM 2877 CA TYR A 206 −75.581 32.281 3.805 1.00 30.41 C ATOM 2879 CB TYR A 206 −74.801 32.170 2.493 1.00 30.20 C ATOM 2882 CG TYR A 206 −75.180 33.173 1.425 1.00 29.62 C ATOM 2883 CD1 TYR A 206 −74.721 34.482 1.484 1.00 30.32 C ATOM 2885 CE1 TYR A 206 −75.047 35.412 .489 1.00 29.70 C ATOM 2887 CZ TYR A 206 −75.830 35.028 −.578 1.00 28.41 C ATOM 2888 OH TYR A 206 −76.155 35.956 −1.548 1.00 26.74 O ATOM 2890 CE2 TYR A 206 −76.291 33.724 −.659 1.00 28.16 C ATOM 2892 CD2 TYR A 206 −75.958 32.806 .335 1.00 28.39 C ATOM 2894 C TYR A 206 −77.038 31.918 3.561 1.00 31.15 C ATOM 2895 O TYR A 206 −77.858 32.781 3.268 1.00 31.30 O ATOM 2897 N ARG A 207 −77.341 30.631 3.676 1.00 32.05 N ATOM 2898 CA ARG A 207 −78.691 30.128 3.555 1.00 32.81 C ATOM 2900 CB ARG A 207 −78.684 28.623 3.813 1.00 32.86 C ATOM 2903 CG ARG A 207 −80.028 27.941 3.673 1.00 34.01 C ATOM 2906 CD ARG A 207 −80.066 26.632 4.450 1.00 35.11 C ATOM 2909 NE ARG A 207 −79.096 25.669 3.939 1.00 35.35 N ATOM 2911 CZ ARG A 207 −79.353 24.737 3.022 1.00 36.00 C ATOM 2912 NH1 ARG A 207 −80.562 24.611 2.478 1.00 35.55 N ATOM 2915 NH2 ARG A 207 −78.381 23.918 2.640 1.00 37.05 N ATOM 2918 C ARG A 207 −79.609 30.826 4.550 1.00 33.57 C ATOM 2919 O ARG A 207 −80.783 31.003 4.263 1.00 33.82 O ATOM 2921 N LYS A 208 −79.064 31.223 5.707 1.00 34.58 N ATOM 2922 CA LYS A 208 −79.835 31.830 6.812 1.00 35.21 C ATOM 2924 CB LYS A 208 −79.137 31.599 8.159 1.00 35.05 C ATOM 2927 CG LYS A 208 −78.847 30.147 8.496 1.00 34.78 C ATOM 2930 CD LYS A 208 −78.583 29.974 9.980 1.00 34.44 C ATOM 2933 CE LYS A 208 −77.992 28.619 10.309 1.00 34.16 C ATOM 2936 NZ LYS A 208 −76.540 28.693 10.572 1.00 33.81 N ATOM 2940 C LYS A 208 −80.075 33.333 6.663 1.00 36.06 C ATOM 2941 O LYS A 208 −81.032 33.857 7.226 1.00 36.19 O ATOM 2943 N LYS A 209 −79.197 34.032 5.946 1.00 36.93 N ATOM 2944 CA LYS A 209 −79.412 35.445 5.652 1.00 37.77 C ATOM 2946 CB LYS A 209 −78.284 35.998 4.779 1.00 38.18 C ATOM 2949 CG LYS A 209 −76.928 36.134 5.458 1.00 39.90 C ATOM 2952 CD LYS A 209 −75.982 37.023 4.621 1.00 42.39 C ATOM 2955 CE LYS A 209 −74.531 37.016 5.169 1.00 44.21 C ATOM 2958 NZ LYS A 209 −74.350 37.688 6.509 1.00 44.75 N ATOM 2962 C LYS A 209 −80.738 35.600 4.911 1.00 37.89 C ATOM 2963 O LYS A 209 −81.049 34.785 4.036 1.00 38.20 O ATOM 2965 N GLU A 210 −81.518 36.632 5.243 1.00 37.87 N ATOM 2966 CA GLU A 210 −82.847 36.797 4.630 1.00 37.72 C ATOM 2968 CB GLU A 210 −83.821 37.578 5.549 1.00 38.19 C ATOM 2971 CG GLU A 210 −83.850 39.130 5.404 1.00 39.68 C ATOM 2974 CD GLU A 210 −85.270 39.736 5.534 1.00 41.27 C ATOM 2975 OE1 GLU A 210 −86.172 39.100 6.136 1.00 41.67 O ATOM 2976 OE2 GLU A 210 −85.482 40.859 5.019 1.00 42.17 O ATOM 2977 C GLU A 210 −82.760 37.394 3.219 1.00 36.68 C ATOM 2978 O GLU A 210 −83.605 37.103 2.371 1.00 36.39 O ATOM 2980 N ASP A 211 −81.725 38.198 2.969 1.00 35.65 N ATOM 2981 CA ASP A 211 −81.481 38.777 1.632 1.00 34.94 C ATOM 2983 CB ASP A 211 −81.064 40.257 1.740 1.00 35.22 C ATOM 2986 CG ASP A 211 −79.811 40.477 2.599 1.00 35.84 C ATOM 2987 OD1 ASP A 211 −79.379 39.557 3.341 1.00 35.60 O ATOM 2988 OD2 ASP A 211 −79.276 41.606 2.536 1.00 36.73 O ATOM 2989 C ASP A 211 −80.451 37.989 .811 1.00 33.73 C ATOM 2990 O ASP A 211 −79.753 38.556 −.021 1.00 33.40 O ATOM 2992 N ALA A 212 −80.366 36.682 1.057 1.00 32.53 N ATOM 2993 CA ALA A 212 −79.506 35.783 .293 1.00 31.40 C ATOM 2995 CB ALA A 212 −79.569 34.382 .889 1.00 30.79 C ATOM 2999 C ALA A 212 −79.940 35.762 −1.176 1.00 30.60 C ATOM 3000 O ALA A 212 −81.124 35.594 −1.467 1.00 30.37 O ATOM 3002 N ASN A 213 −79.000 35.967 −2.097 1.00 29.71 N ATOM 3003 CA ASN A 213 −79.304 35.809 −3.520 1.00 29.27 C ATOM 3005 CB ASN A 213 −78.144 36.315 −4.402 1.00 29.30 C ATOM 3008 CG ASN A 213 −78.442 36.217 −5.911 1.00 29.07 C ATOM 3009 OD1 ASN A 213 −78.437 37.215 −6.624 1.00 29.38 O ATOM 3010 ND2 ASN A 213 −78.691 35.015 −6.389 1.00 28.37 N ATOM 3013 C ASN A 213 −79.634 34.328 −3.785 1.00 28.81 C ATOM 3014 O ASN A 213 −78.784 33.455 −3.658 1.00 29.04 O ATOM 3016 N GLN A 214 −80.880 34.053 −4.145 1.00 28.04 N ATOM 3017 CA GLN A 214 −81.376 32.692 −4.191 1.00 27.32 C ATOM 3019 CB GLN A 214 −82.906 32.700 −4.178 1.00 27.47 C ATOM 3022 CG GLN A 214 −83.505 33.269 −2.889 1.00 27.68 C ATOM 3025 CD GLN A 214 −83.294 32.359 −1.688 1.00 27.54 C ATOM 3026 OE1 GLN A 214 −83.940 31.320 −1.571 1.00 28.19 O ATOM 3027 NE2 GLN A 214 −82.392 32.748 −.790 1.00 26.90 N ATOM 3030 C GLN A 214 −80.858 31.902 −5.385 1.00 26.71 C ATOM 3031 O GLN A 214 −80.863 30.668 −5.355 1.00 26.91 O ATOM 3033 N VAL A 215 −80.439 32.600 −6.442 1.00 25.81 N ATOM 3034 CA VAL A 215 −79.789 31.947 −7.588 1.00 24.88 C ATOM 3036 CB VAL A 215 −79.651 32.894 −8.808 1.00 24.81 C ATOM 3038 CG1 VAL A 215 −78.459 32.483 −9.680 1.00 24.94 C ATOM 3042 CG2 VAL A 215 −80.935 32.907 −9.620 1.00 23.74 C ATOM 3046 C VAL A 215 −78.415 31.427 −7.176 1.00 24.18 C ATOM 3047 O VAL A 215 −78.073 30.282 −7.430 1.00 23.74 O ATOM 3049 N LEU A 216 −77.650 32.283 −6.510 1.00 23.78 N ATOM 3050 CA LEU A 216 −76.299 31.961 −6.036 1.00 23.33 C ATOM 3052 CB LEU A 216 −75.680 33.195 −5.373 1.00 23.10 C ATOM 3055 CG LEU A 216 −74.194 33.192 −5.059 1.00 22.91 C ATOM 3057 CD1 LEU A 216 −73.383 32.962 −6.312 1.00 22.88 C ATOM 3061 CD2 LEU A 216 −73.826 34.518 −4.424 1.00 22.03 C ATOM 3065 C LEU A 216 −76.333 30.797 −5.050 1.00 22.92 C ATOM 3066 O LEU A 216 −75.598 29.826 −5.201 1.00 23.38 O ATOM 3068 N LEU A 217 −77.214 30.890 −4.060 1.00 22.09 N ATOM 3069 CA LEU A 217 −77.367 29.851 −3.054 1.00 21.14 C ATOM 3071 CB LEU A 217 −78.488 30.225 −2.090 1.00 21.11 C ATOM 3074 CG LEU A 217 −78.782 29.236 −.961 1.00 21.08 C ATOM 3076 CD1 LEU A 217 −77.703 29.267 .101 1.00 19.87 C ATOM 3080 CD2 LEU A 217 −80.146 29.535 −.360 1.00 21.46 C ATOM 3084 C LEU A 217 −77.682 28.517 −3.685 1.00 20.38 C ATOM 3085 O LEU A 217 −77.133 27.508 −3.286 1.00 20.04 O ATOM 3087 N GLU A 218 −78.579 28.512 −4.661 1.00 19.97 N ATOM 3088 CA GLU A 218 −79.027 27.260 −5.273 1.00 19.72 C ATOM 3090 CB GLU A 218 −80.220 27.499 −6.212 1.00 19.87 C ATOM 3093 CG GLU A 218 −81.005 26.228 −6.627 1.00 21.03 C ATOM 3096 CD GLU A 218 −82.303 26.535 −7.424 1.00 22.59 C ATOM 3097 OE1 GLU A 218 −82.643 27.730 −7.619 1.00 23.61 O ATOM 3098 OE2 GLU A 218 −82.983 25.578 −7.863 1.00 22.31 O ATOM 3099 C GLU A 218 −77.854 26.613 −6.009 1.00 19.03 C ATOM 3100 O GLU A 218 −77.522 25.452 −5.764 1.00 18.97 O ATOM 3102 N LEU A 219 −77.203 27.381 −6.878 1.00 18.06 N ATOM 3103 CA LEU A 219 −76.012 26.907 −7.573 1.00 17.15 C ATOM 3105 CB LEU A 219 −75.439 28.029 −8.418 1.00 16.75 C ATOM 3108 CG LEU A 219 −74.196 27.717 −9.231 1.00 16.01 C ATOM 3110 CD1 LEU A 219 −74.511 26.832 −10.404 1.00 12.99 C ATOM 3114 CD2 LEU A 219 −73.577 29.028 −9.675 1.00 16.20 C ATOM 3118 C LEU A 219 −74.973 26.409 −6.570 1.00 16.75 C ATOM 3119 O LEU A 219 −74.377 25.355 −6.757 1.00 16.47 O ATOM 3121 N ALA A 220 −74.786 27.169 −5.496 1.00 16.40 N ATOM 3122 CA ALA A 220 −73.858 26.808 −4.422 1.00 16.15 C ATOM 3124 CB ALA A 220 −73.906 27.830 −3.302 1.00 16.13 C ATOM 3128 C ALA A 220 −74.137 25.436 −3.862 1.00 16.03 C ATOM 3129 O ALA A 220 −73.253 24.603 −3.799 1.00 16.30 O ATOM 3131 N ILE A 221 −75.371 25.201 −3.447 1.00 16.24 N ATOM 3132 CA ILE A 221 −75.731 23.916 −2.857 1.00 16.33 C ATOM 3134 CB ILE A 221 −77.203 23.895 −2.352 1.00 15.94 C ATOM 3136 CG1 ILE A 221 −77.410 24.879 −1.203 1.00 15.36 C ATOM 3139 CD1 ILE A 221 −78.842 25.234 −.962 1.00 14.49 C ATOM 3143 CG2 ILE A 221 −77.571 22.537 −1.836 1.00 15.18 C ATOM 3147 C ILE A 221 −75.509 22.841 −3.911 1.00 17.06 C ATOM 3148 O ILE A 221 −74.899 21.819 −3.653 1.00 16.51 O ATOM 3150 N LEU A 222 −75.981 23.138 −5.117 1.00 18.53 N ATOM 3151 CA LEU A 222 −76.006 22.207 −6.243 1.00 19.25 C ATOM 3153 CB LEU A 222 −76.657 22.891 −7.445 1.00 19.18 C ATOM 3156 CG LEU A 222 −77.037 21.972 −8.597 1.00 19.65 C ATOM 3158 CD1 LEU A 222 −78.318 22.489 −9.268 1.00 19.24 C ATOM 3162 CD2 LEU A 222 −75.869 21.788 −9.597 1.00 18.75 C ATOM 3166 C LEU A 222 −74.618 21.751 −6.630 1.00 20.07 C ATOM 3167 O LEU A 222 −74.381 20.558 −6.778 1.00 20.55 O ATOM 3169 N ASP A 223 −73.710 22.711 −6.797 1.00 20.92 N ATOM 3170 CA ASP A 223 −72.330 22.427 −7.189 1.00 21.43 C ATOM 3172 CB ASP A 223 −71.621 23.723 −7.585 1.00 21.63 C ATOM 3175 CG ASP A 223 −70.202 23.495 −8.070 1.00 22.51 C ATOM 3176 OD1 ASP A 223 −69.296 23.282 −7.225 1.00 24.67 O ATOM 3177 OD2 ASP A 223 −69.990 23.544 −9.296 1.00 22.73 O ATOM 3178 C ASP A 223 −71.573 21.722 −6.060 1.00 21.79 C ATOM 3179 O ASP A 223 −70.843 20.764 −6.313 1.00 21.73 O ATOM 3181 N TYR A 224 −71.755 22.182 −4.820 1.00 22.14 N ATOM 3182 CA TYR A 224 −71.120 21.529 −3.686 1.00 22.22 C ATOM 3184 CB TYR A 224 −71.462 22.190 −2.355 1.00 22.38 C ATOM 3187 CG TYR A 224 −70.673 21.542 −1.249 1.00 22.65 C ATOM 3188 CD1 TYR A 224 −69.356 21.864 −1.053 1.00 22.59 C ATOM 3190 CE1 TYR A 224 −68.622 21.258 −.098 1.00 23.38 C ATOM 3192 CZ TYR A 224 −69.177 20.288 .670 1.00 23.22 C ATOM 3193 OH TYR A 224 −68.402 19.684 1.620 1.00 23.93 O ATOM 3195 CE2 TYR A 224 −70.483 19.931 .500 1.00 23.36 C ATOM 3197 CD2 TYR A 224 −71.221 20.547 −.464 1.00 23.41 C ATOM 3199 C TYR A 224 −71.485 20.065 −3.605 1.00 22.52 C ATOM 3200 O TYR A 224 −70.641 19.233 −3.311 1.00 22.93 O ATOM 3202 N ASN A 225 −72.742 19.749 −3.856 1.00 22.94 N ATOM 3203 CA ASN A 225 −73.187 18.374 −3.801 1.00 23.44 C ATOM 3205 CB ASN A 225 −74.706 18.310 −3.729 1.00 23.34 C ATOM 3208 CG ASN A 225 −75.210 18.579 −2.352 1.00 22.62 C ATOM 3209 OD1 ASN A 225 −74.749 17.977 −1.407 1.00 23.33 O ATOM 3210 ND2 ASN A 225 −76.146 19.494 −2.223 1.00 22.52 N ATOM 3213 C ASN A 225 −72.694 17.523 −4.959 1.00 24.26 C ATOM 3214 O ASN A 225 −72.408 16.328 −4.767 1.00 24.88 O ATOM 3216 N MET A 226 −72.607 18.119 −6.150 1.00 24.67 N ATOM 3217 CA MET A 226 −72.167 17.395 −7.349 1.00 24.95 C ATOM 3219 CB MET A 226 −72.421 18.237 −8.594 1.00 25.37 C ATOM 3222 CG MET A 226 −71.785 17.713 −9.873 1.00 27.23 C ATOM 3225 SD MET A 226 −70.837 19.010 −10.708 1.00 31.73 S ATOM 3226 CE MET A 226 −72.185 20.000 −11.367 1.00 31.30 C ATOM 3230 C MET A 226 −70.688 17.045 −7.247 1.00 24.70 C ATOM 3231 O MET A 226 −70.291 15.929 −7.568 1.00 24.91 O ATOM 3233 N ILE A 227 −69.873 17.995 −6.799 1.00 24.43 N ATOM 3234 CA ILE A 227 −68.456 17.726 −6.598 1.00 24.18 C ATOM 3236 CB ILE A 227 −67.656 18.971 −6.154 1.00 24.15 C ATOM 3238 CG1 ILE A 227 −67.628 20.021 −7.253 1.00 23.64 C ATOM 3241 CD1 ILE A 227 −66.853 21.246 −6.880 1.00 23.11 C ATOM 3245 CG2 ILE A 227 −66.229 18.603 −5.827 1.00 24.36 C ATOM 3249 C ILE A 227 −68.329 16.645 −5.546 1.00 23.98 C ATOM 3250 O ILE A 227 −67.609 15.689 −5.747 1.00 24.35 O ATOM 3252 N GLN A 228 −69.048 16.779 −4.439 1.00 23.79 N ATOM 3253 CA GLN A 228 −69.020 15.754 −3.382 1.00 23.66 C ATOM 3255 CB GLN A 228 −70.077 16.010 −2.305 1.00 23.64 C ATOM 3258 CG GLN A 228 −69.972 15.049 −1.145 1.00 22.91 C ATOM 3261 CD GLN A 228 −70.891 15.417 −.033 1.00 23.26 C ATOM 3262 OE1 GLN A 228 −72.082 15.098 −.069 1.00 25.64 O ATOM 3263 NE2 GLN A 228 −70.357 16.083 .978 1.00 21.77 N ATOM 3266 C GLN A 228 −69.243 14.349 −3.893 1.00 23.54 C ATOM 3267 O GLN A 228 −68.664 13.412 −3.357 1.00 23.59 O ATOM 3269 N SER A 229 −70.105 14.194 −4.893 1.00 23.27 N ATOM 3270 CA SER A 229 −70.394 12.868 −5.406 1.00 23.35 C ATOM 3272 CB SER A 229 −71.753 12.812 −6.095 1.00 23.31 C ATOM 3275 OG SER A 229 −71.836 13.823 −7.060 1.00 24.31 O ATOM 3277 C SER A 229 −69.287 12.394 −6.331 1.00 23.19 C ATOM 3278 O SER A 229 −69.130 11.194 −6.512 1.00 23.44 O ATOM 3280 N VAL A 230 −68.512 13.306 −6.914 1.00 23.14 N ATOM 3281 CA VAL A 230 −67.269 12.874 −7.552 1.00 23.00 C ATOM 3283 CB VAL A 230 −66.469 13.998 −8.253 1.00 22.75 C ATOM 3285 CG1 VAL A 230 −65.091 13.470 −8.667 1.00 21.87 C ATOM 3289 CG2 VAL A 230 −67.222 14.539 −9.459 1.00 21.74 C ATOM 3293 C VAL A 230 −66.417 12.268 −6.452 1.00 23.35 C ATOM 3294 O VAL A 230 −65.917 11.173 −6.589 1.00 23.68 O ATOM 3296 N TYR A 231 −66.284 12.968 −5.340 1.00 23.96 N ATOM 3297 CA TYR A 231 −65.414 12.509 −4.274 1.00 24.60 C ATOM 3299 CB TYR A 231 −65.486 13.426 −3.051 1.00 24.69 C ATOM 3302 CG TYR A 231 −64.963 14.837 −3.211 1.00 24.11 C ATOM 3303 CD1 TYR A 231 −64.071 15.190 −4.214 1.00 24.31 C ATOM 3305 CE1 TYR A 231 −63.592 16.491 −4.322 1.00 24.63 C ATOM 3307 CZ TYR A 231 −63.994 17.441 −3.406 1.00 25.13 C ATOM 3308 OH TYR A 231 −63.554 18.754 −3.456 1.00 24.64 O ATOM 3310 CE2 TYR A 231 −64.863 17.086 −2.402 1.00 25.76 C ATOM 3312 CD2 TYR A 231 −65.329 15.800 −2.308 1.00 24.28 C ATOM 3314 C TYR A 231 −65.785 11.111 −3.833 1.00 25.26 C ATOM 3315 O TYR A 231 −64.917 10.315 −3.488 1.00 25.44 O ATOM 3317 N GLN A 232 −67.079 10.819 −3.833 1.00 26.04 N ATOM 3318 CA GLN A 232 −67.566 9.532 −3.362 1.00 26.57 C ATOM 3320 CB GLN A 232 −69.060 9.621 −3.057 1.00 26.44 C ATOM 3323 CG GLN A 232 −69.339 10.397 −1.778 1.00 26.25 C ATOM 3326 CD GLN A 232 −70.786 10.819 −1.630 1.00 26.53 C ATOM 3327 OE1 GLN A 232 −71.667 10.305 −2.318 1.00 27.77 O ATOM 3328 NE2 GLN A 232 −71.040 11.759 −.723 1.00 25.51 N ATOM 3331 C GLN A 232 −67.238 8.414 −4.351 1.00 27.44 C ATOM 3332 O GLN A 232 −66.852 7.319 −3.935 1.00 27.33 O ATOM 3334 N ARG A 233 −67.373 8.691 −5.649 1.00 28.66 N ATOM 3335 CA ARG A 233 −66.905 7.768 −6.685 1.00 29.86 C ATOM 3337 CB ARG A 233 −67.212 8.292 −8.090 1.00 30.08 C ATOM 3340 CG ARG A 233 −66.378 7.634 −9.179 1.00 32.80 C ATOM 3343 CD ARG A 233 −66.913 7.923 −10.572 1.00 36.74 C ATOM 3346 NE ARG A 233 −66.962 9.363 −10.860 1.00 40.33 N ATOM 3348 CZ ARG A 233 −68.069 10.119 −10.891 1.00 43.12 C ATOM 3349 NH1 ARG A 233 −69.276 9.600 −10.655 1.00 44.55 N ATOM 3352 NH2 ARG A 233 −67.971 11.418 −11.169 1.00 43.38 N ATOM 3355 C ARG A 233 −65.401 7.518 −6.514 1.00 30.34 C ATOM 3356 O ARG A 233 −64.962 6.374 −6.412 1.00 30.55 O ATOM 3358 N ASP A 234 −64.621 8.591 −6.461 1.00 31.00 N ATOM 3359 CA ASP A 234 −63.187 8.487 −6.205 1.00 31.48 C ATOM 3361 CB ASP A 234 −62.594 9.870 −5.942 1.00 31.56 C ATOM 3364 CG ASP A 234 −62.573 10.741 −7.167 1.00 32.78 C ATOM 3365 OD1 ASP A 234 −62.911 10.249 −8.276 1.00 34.25 O ATOM 3366 OD2 ASP A 234 −62.215 11.930 −7.011 1.00 34.81 O ATOM 3367 C ASP A 234 −62.885 7.596 −5.010 1.00 31.70 C ATOM 3368 O ASP A 234 −61.985 6.780 −5.053 1.00 31.56 O ATOM 3370 N LEU A 235 −63.647 7.766 −3.943 1.00 32.43 N ATOM 3371 CA LEU A 235 −63.366 7.102 −2.685 1.00 33.04 C ATOM 3373 CB LEU A 235 −64.072 7.833 −1.553 1.00 32.57 C ATOM 3376 CG LEU A 235 −63.884 7.252 −.167 1.00 30.85 C ATOM 3378 CD1 LEU A 235 −62.428 7.261 .174 1.00 28.78 C ATOM 3382 CD2 LEU A 235 −64.703 8.050 .823 1.00 29.93 C ATOM 3386 C LEU A 235 −63.789 5.637 −2.686 1.00 34.69 C ATOM 3387 O LEU A 235 −63.123 4.812 −2.065 1.00 35.29 O ATOM 3389 N ARG A 236 −64.893 5.299 −3.354 1.00 36.09 N ATOM 3390 CA ARG A 236 −65.290 3.893 −3.458 1.00 37.26 C ATOM 3392 CB ARG A 236 −66.672 3.736 −4.103 1.00 37.64 C ATOM 3395 CG ARG A 236 −67.839 4.000 −3.157 1.00 39.15 C ATOM 3398 CD ARG A 236 −69.162 3.528 −3.741 1.00 40.25 C ATOM 3401 NE ARG A 236 −69.385 4.046 −5.095 1.00 41.64 N ATOM 3403 CZ ARG A 236 −69.837 5.269 −5.392 1.00 42.54 C ATOM 3404 NH1 ARG A 236 −70.115 6.147 −4.430 1.00 42.18 N ATOM 3407 NH2 ARG A 236 −70.012 5.621 −6.668 1.00 43.04 N ATOM 3410 C ARG A 236 −64.266 3.108 −4.262 1.00 37.81 C ATOM 3411 O ARG A 236 −64.104 1.912 −4.060 1.00 38.07 O ATOM 3413 N GLU A 237 −63.584 3.801 −5.168 1.00 38.69 N ATOM 3414 CA GLU A 237 −62.639 3.189 −6.102 1.00 39.45 C ATOM 3416 CB GLU A 237 −62.452 4.108 −7.338 1.00 40.25 C ATOM 3419 CG GLU A 237 −62.268 3.387 −8.710 1.00 43.02 C ATOM 3422 CD GLU A 237 −60.835 3.458 −9.287 1.00 46.64 C ATOM 3423 OE1 GLU A 237 −60.093 4.440 −8.997 1.00 48.03 O ATOM 3424 OE2 GLU A 237 −60.466 2.519 −10.047 1.00 48.35 O ATOM 3425 C GLU A 237 −61.310 2.905 −5.408 1.00 38.70 C ATOM 3426 O GLU A 237 −60.832 1.782 −5.440 1.00 38.33 O ATOM 3428 N THR A 238 −60.726 3.908 −4.764 1.00 38.40 N ATOM 3429 CA THR A 238 −59.504 3.669 −4.009 1.00 38.74 C ATOM 3431 CB THR A 238 −58.710 4.965 −3.593 1.00 38.78 C ATOM 3433 OG1 THR A 238 −59.294 5.583 −2.444 1.00 38.38 O ATOM 3435 CG2 THR A 238 −58.612 5.963 −4.743 1.00 38.94 C ATOM 3439 C THR A 238 −59.802 2.834 −2.773 1.00 39.05 C ATOM 3440 O THR A 238 −58.886 2.294 −2.153 1.00 39.17 O ATOM 3442 N SER A 239 −61.076 2.717 −2.408 1.00 39.34 N ATOM 3443 CA SER A 239 −61.443 1.841 −1.304 1.00 39.47 C ATOM 3445 CB SER A 239 −62.844 2.149 −.792 1.00 39.34 C ATOM 3448 OG SER A 239 −63.087 1.428 .396 1.00 39.94 O ATOM 3450 C SER A 239 −61.313 .367 −1.699 1.00 39.53 C ATOM 3451 O SER A 239 −60.834 −.439 −.900 1.00 39.53 O ATOM 3453 N ARG A 240 −61.728 .021 −2.921 1.00 39.69 N ATOM 3454 CA ARG A 240 −61.559 −1.341 −3.439 1.00 39.79 C ATOM 3456 CB ARG A 240 −62.105 −1.492 −4.867 1.00 40.34 C ATOM 3459 CG ARG A 240 −63.624 −1.715 −4.947 1.00 43.03 C ATOM 3462 CD ARG A 240 −64.104 −2.125 −6.364 1.00 46.66 C ATOM 3465 NE ARG A 240 −63.780 −1.136 −7.416 1.00 50.46 N ATOM 3467 CZ ARG A 240 −64.535 −.082 −7.775 1.00 53.13 C ATOM 3468 NH1 ARG A 240 −64.112 .732 −8.749 1.00 53.13 N ATOM 3471 NH2 ARG A 240 −65.707 .178 −7.178 1.00 54.02 N ATOM 3474 C ARG A 240 −60.089 −1.704 −3.414 1.00 38.94 C ATOM 3475 O ARG A 240 −59.732 −2.795 −2.978 1.00 39.09 O ATOM 3477 N TRP A 241 −59.246 −.775 −3.862 1.00 37.92 N ATOM 3478 CA TRP A 241 −57.787 −.947 −3.842 1.00 36.93 C ATOM 3480 CB TRP A 241 −57.099 .318 −4.388 1.00 36.57 C ATOM 3483 CG TRP A 241 −55.624 .333 −4.209 1.00 34.71 C ATOM 3484 CD1 TRP A 241 −54.702 −.312 −4.969 1.00 33.50 C ATOM 3486 NE1 TRP A 241 −53.441 −.068 −4.482 1.00 32.62 N ATOM 3488 CE2 TRP A 241 −53.538 .747 −3.392 1.00 31.16 C ATOM 3489 CD2 TRP A 241 −54.896 1.022 −3.191 1.00 32.61 C ATOM 3490 CE3 TRP A 241 −55.268 1.837 −2.117 1.00 32.63 C ATOM 3492 CZ3 TRP A 241 −54.293 2.345 −1.307 1.00 31.31 C ATOM 3494 CH2 TRP A 241 −52.956 2.053 −1.537 1.00 31.81 C ATOM 3496 CZ2 TRP A 241 −52.560 1.252 −2.577 1.00 31.18 C ATOM 3498 C TRP A 241 −57.263 −1.274 −2.444 1.00 36.67 C ATOM 3499 O TRP A 241 −56.540 −2.247 −2.252 1.00 36.32 O ATOM 3501 N TRP A 242 −57.647 −.460 −1.471 1.00 36.59 N ATOM 3502 CA TRP A 242 −57.150 −.593 −.100 1.00 36.80 C ATOM 3504 CB TRP A 242 −57.694 .582 .734 1.00 36.47 C ATOM 3507 CG TRP A 242 −57.113 .754 2.107 1.00 35.59 C ATOM 3508 CD1 TRP A 242 −57.806 .831 3.270 1.00 35.14 C ATOM 3510 NE1 TRP A 242 −56.950 .999 4.328 1.00 34.47 N ATOM 3512 CE2 TRP A 242 −55.667 1.032 3.859 1.00 34.64 C ATOM 3513 CD2 TRP A 242 −55.728 .884 2.461 1.00 35.26 C ATOM 3514 CE3 TRP A 242 −54.531 .882 1.732 1.00 35.22 C ATOM 3516 CZ3 TRP A 242 −53.342 1.024 2.409 1.00 34.30 C ATOM 3518 CH2 TRP A 242 −53.318 1.169 3.799 1.00 34.70 C ATOM 3520 CZ2 TRP A 242 −54.467 1.173 4.542 1.00 34.63 C ATOM 3522 C TRP A 242 −57.482 −1.975 .524 1.00 37.34 C ATOM 3523 O TRP A 242 −56.628 −2.623 1.126 1.00 36.53 O ATOM 3525 N ARG A 243 −58.720 −2.421 .348 1.00 38.54 N ATOM 3526 CA ARG A 243 −59.149 −3.734 .822 1.00 39.71 C ATOM 3528 CB ARG A 243 −60.669 −3.896 .687 1.00 40.10 C ATOM 3531 CG ARG A 243 −61.495 −3.134 1.747 1.00 42.18 C ATOM 3534 CD ARG A 243 −62.826 −2.623 1.169 1.00 45.18 C ATOM 3537 NE ARG A 243 −63.506 −3.656 .369 1.00 48.22 N ATOM 3539 CZ ARG A 243 −64.374 −3.431 −.629 1.00 49.95 C ATOM 3540 NH1 ARG A 243 −64.717 −2.182 −.991 1.00 50.13 N ATOM 3543 NH2 ARG A 243 −64.911 −4.477 −1.273 1.00 49.77 N ATOM 3546 C ARG A 243 −58.438 −4.852 .068 1.00 40.08 C ATOM 3547 O ARG A 243 −58.084 −5.870 .665 1.00 40.45 O ATOM 3549 N ARG A 244 −58.236 −4.663 −1.236 1.00 40.42 N ATOM 3550 CA ARG A 244 −57.499 −5.621 −2.063 1.00 40.65 C ATOM 3552 CB ARG A 244 −57.370 −5.100 −3.503 1.00 41.29 C ATOM 3555 CG ARG A 244 −56.939 −6.126 −4.560 1.00 43.27 C ATOM 3558 CD ARG A 244 −58.090 −7.062 −4.952 1.00 46.01 C ATOM 3561 NE ARG A 244 −57.595 −8.337 −5.485 1.00 48.77 N ATOM 3563 CZ ARG A 244 −57.075 −9.332 −4.752 1.00 51.17 C ATOM 3564 NH1 ARG A 244 −56.968 −9.234 −3.422 1.00 51.63 N ATOM 3567 NH2 ARG A 244 −56.656 −10.448 −5.353 1.00 52.11 N ATOM 3570 C ARG A 244 −56.120 −5.861 −1.465 1.00 40.12 C ATOM 3571 O ARG A 244 −55.728 −7.000 −1.235 1.00 39.96 O ATOM 3573 N VAL A 245 −55.399 −4.778 −1.201 1.00 39.78 N ATOM 3574 CA VAL A 245 −54.099 −4.858 −.543 1.00 39.68 C ATOM 3576 CB VAL A 245 −53.430 −3.458 −.437 1.00 39.70 C ATOM 3578 CG1 VAL A 245 −53.133 −2.914 −1.824 1.00 39.54 C ATOM 3582 CG2 VAL A 245 −52.145 −3.507 .395 1.00 39.41 C ATOM 3586 C VAL A 245 −54.262 −5.472 .841 1.00 39.73 C ATOM 3587 O VAL A 245 −53.455 −6.291 1.253 1.00 39.53 O ATOM 3589 N GLY A 246 −55.312 −5.051 1.544 1.00 40.11 N ATOM 3590 CA GLY A 246 −55.705 −5.617 2.839 1.00 40.35 C ATOM 3593 C GLY A 246 −54.621 −5.648 3.894 1.00 40.58 C ATOM 3594 O GLY A 246 −54.396 −6.676 4.510 1.00 40.68 O ATOM 3596 N LEU A 247 −53.963 −4.522 4.129 1.00 41.15 N ATOM 3597 CA LEU A 247 −52.778 −4.519 4.982 1.00 41.71 C ATOM 3599 CB LEU A 247 −51.808 −3.422 4.537 1.00 41.60 C ATOM 3602 CG LEU A 247 −50.334 −3.815 4.441 1.00 40.83 C ATOM 3604 CD1 LEU A 247 −50.158 −5.014 3.539 1.00 40.54 C ATOM 3608 CD2 LEU A 247 −49.534 −2.644 3.918 1.00 39.92 C ATOM 3612 C LEU A 247 −53.136 −4.385 6.471 1.00 42.60 C ATOM 3613 O LEU A 247 −52.588 −5.111 7.313 1.00 42.06 O ATOM 3615 N ALA A 248 −54.064 −3.475 6.788 1.00 43.75 N ATOM 3616 CA ALA A 248 −54.603 −3.352 8.162 1.00 44.52 C ATOM 3618 CB ALA A 248 −55.712 −2.296 8.210 1.00 44.31 C ATOM 3622 C ALA A 248 −55.129 −4.706 8.695 1.00 45.10 C ATOM 3623 O ALA A 248 −54.969 −5.041 9.875 1.00 44.96 O ATOM 3625 N THR A 249 −55.742 −5.477 7.802 1.00 45.91 N ATOM 3626 CA THR A 249 −56.328 −6.768 8.154 1.00 46.50 C ATOM 3628 CB THR A 249 −57.303 −7.277 7.041 1.00 46.48 C ATOM 3630 OG1 THR A 249 −56.583 −8.039 6.063 1.00 46.20 O ATOM 3632 CG2 THR A 249 −58.033 −6.102 6.350 1.00 46.70 C ATOM 3636 C THR A 249 −55.257 −7.840 8.447 1.00 47.06 C ATOM 3637 O THR A 249 −55.531 −8.813 9.159 1.00 47.22 O ATOM 3639 N LYS A 250 −54.049 −7.661 7.905 1.00 47.52 N ATOM 3640 CA LYS A 250 −52.952 −8.620 8.096 1.00 47.91 C ATOM 3642 CB LYS A 250 −52.319 −8.976 6.744 1.00 48.09 C ATOM 3645 CG LYS A 250 −52.911 −10.229 6.088 1.00 48.91 C ATOM 3648 CD LYS A 250 −52.210 −11.510 6.585 1.00 49.88 C ATOM 3651 CE LYS A 250 −53.066 −12.760 6.349 1.00 50.12 C ATOM 3654 NZ LYS A 250 −52.385 −14.011 6.791 1.00 49.99 N ATOM 3658 C LYS A 250 −51.880 −8.129 9.078 1.00 48.13 C ATOM 3659 O LYS A 250 −51.252 −8.939 9.759 1.00 47.89 O ATOM 3661 N LEU A 251 −51.667 −6.812 9.134 1.00 48.63 N ATOM 3662 CA LEU A 251 −50.758 −6.187 10.114 1.00 48.83 C ATOM 3664 CB LEU A 251 −49.981 −5.020 9.485 1.00 48.74 C ATOM 3667 CG LEU A 251 −48.569 −5.296 8.960 1.00 48.51 C ATOM 3669 CD1 LEU A 251 −48.472 −6.594 8.174 1.00 47.96 C ATOM 3673 CD2 LEU A 251 −48.102 −4.115 8.116 1.00 48.76 C ATOM 3677 C LEU A 251 −51.559 −5.703 11.324 1.00 49.17 C ATOM 3678 O LEU A 251 −52.176 −4.632 11.304 1.00 49.28 O ATOM 3680 N HIS A 252 −51.521 −6.486 12.393 1.00 49.53 N ATOM 3681 CA HIS A 252 −52.470 −6.322 13.494 1.00 50.02 C ATOM 3683 CB HIS A 252 −52.598 −7.647 14.266 1.00 50.42 C ATOM 3686 CG HIS A 252 −52.860 −8.834 13.380 1.00 52.23 C ATOM 3687 ND1 HIS A 252 −54.032 −8.989 12.667 1.00 53.75 N ATOM 3689 CE1 HIS A 252 −53.978 −10.113 11.973 1.00 54.43 C ATOM 3691 NE2 HIS A 252 −52.810 −10.689 12.201 1.00 54.52 N ATOM 3693 CD2 HIS A 252 −52.090 −9.910 13.077 1.00 53.70 C ATOM 3695 C HIS A 252 −52.161 −5.147 14.441 1.00 49.64 C ATOM 3696 O HIS A 252 −52.951 −4.849 15.336 1.00 49.61 O ATOM 3698 N PHE A 253 −51.027 −4.483 14.229 1.00 49.37 N ATOM 3699 CA PHE A 253 −50.652 −3.273 14.973 1.00 49.15 C ATOM 3701 CB PHE A 253 −49.144 −3.273 15.260 1.00 49.07 C ATOM 3704 CG PHE A 253 −48.307 −3.112 14.025 1.00 48.30 C ATOM 3705 CD1 PHE A 253 −48.028 −1.851 13.518 1.00 48.10 C ATOM 3707 CE1 PHE A 253 −47.290 −1.702 12.349 1.00 48.21 C ATOM 3709 CZ PHE A 253 −46.825 −2.825 11.675 1.00 47.88 C ATOM 3711 CE2 PHE A 253 −47.101 −4.090 12.175 1.00 47.66 C ATOM 3713 CD2 PHE A 253 −47.842 −4.226 13.338 1.00 47.74 C ATOM 3715 C PHE A 253 −50.974 −2.006 14.176 1.00 49.31 C ATOM 3716 O PHE A 253 −50.846 −.893 14.702 1.00 49.01 O ATOM 3718 N ALA A 254 −51.365 −2.185 12.910 1.00 49.48 N ATOM 3719 CA ALA A 254 −51.412 −1.095 11.931 1.00 49.63 C ATOM 3721 CB ALA A 254 −51.344 −1.663 10.524 1.00 49.64 C ATOM 3725 C ALA A 254 −52.650 −.224 12.061 1.00 49.77 C ATOM 3726 O ALA A 254 −53.761 −.735 12.219 1.00 49.86 O ATOM 3728 N ARG A 255 −52.452 1.090 11.975 1.00 49.93 N ATOM 3729 CA ARG A 255 −53.562 2.042 11.908 1.00 50.27 C ATOM 3731 CB ARG A 255 −53.094 3.468 12.237 1.00 50.43 C ATOM 3734 CG ARG A 255 −52.678 3.736 13.696 1.00 50.82 C ATOM 3737 CD ARG A 255 −52.242 5.211 13.887 1.00 51.32 C ATOM 3740 NE ARG A 255 −51.003 5.522 13.155 1.00 51.81 N ATOM 3742 CZ ARG A 255 −50.571 6.746 12.829 1.00 51.67 C ATOM 3743 NH1 ARG A 255 −51.264 7.839 13.146 1.00 51.63 N ATOM 3746 NH2 ARG A 255 −49.427 6.877 12.162 1.00 51.52 N ATOM 3749 C ARG A 255 −54.160 2.040 10.497 1.00 50.32 C ATOM 3750 O ARG A 255 −53.416 2.081 9.504 1.00 50.35 O ATOM 3752 N ASP A 256 −55.492 2.005 10.412 1.00 50.17 N ATOM 3753 CA ASP A 256 −56.190 2.090 9.128 1.00 50.18 C ATOM 3755 CB ASP A 256 −57.259 1.009 9.037 1.00 50.37 C ATOM 3758 CG ASP A 256 −58.095 1.130 7.780 1.00 50.96 C ATOM 3759 OD1 ASP A 256 −59.252 1.601 7.881 1.00 52.00 O ATOM 3760 OD2 ASP A 256 −57.581 .787 6.693 1.00 50.94 O ATOM 3761 C ASP A 256 −56.838 3.470 8.945 1.00 49.85 C ATOM 3762 O ASP A 256 −57.812 3.804 9.624 1.00 50.13 O ATOM 3764 N ARG A 257 −56.315 4.263 8.013 1.00 49.11 N ATOM 3765 CA ARG A 257 −56.712 5.665 7.913 1.00 48.59 C ATOM 3767 CB ARG A 257 −55.622 6.553 8.529 1.00 48.79 C ATOM 3770 CG ARG A 257 −55.318 6.275 10.006 1.00 49.85 C ATOM 3773 CD ARG A 257 −56.538 6.480 10.908 1.00 51.01 C ATOM 3776 NE ARG A 257 −56.198 7.274 12.089 1.00 51.80 N ATOM 3778 CZ ARG A 257 −55.779 6.791 13.260 1.00 52.00 C ATOM 3779 NH1 ARG A 257 −55.643 5.486 13.468 1.00 51.64 N ATOM 3782 NH2 ARG A 257 −55.501 7.638 14.245 1.00 52.62 N ATOM 3785 C ARG A 257 −56.988 6.112 6.477 1.00 47.58 C ATOM 3786 O ARG A 257 −56.476 7.144 6.031 1.00 47.40 O ATOM 3788 N LEU A 258 −57.814 5.352 5.761 1.00 46.18 N ATOM 3789 CA LEU A 258 −58.094 5.672 4.358 1.00 44.78 C ATOM 3791 CB LEU A 258 −58.777 4.508 3.629 1.00 44.57 C ATOM 3794 CG LEU A 258 −58.917 4.731 2.121 1.00 43.79 C ATOM 3796 CD1 LEU A 258 −57.557 4.661 1.478 1.00 43.89 C ATOM 3800 CD2 LEU A 258 −59.850 3.733 1.492 1.00 42.88 C ATOM 3804 C LEU A 258 −58.970 6.907 4.259 1.00 43.52 C ATOM 3805 O LEU A 258 −58.643 7.849 3.545 1.00 43.42 O ATOM 3807 N ILE A 259 −60.080 6.895 4.983 1.00 41.98 N ATOM 3808 CA ILE A 259 −61.072 7.948 4.843 1.00 40.89 C ATOM 3810 CB ILE A 259 −62.349 7.703 5.693 1.00 41.02 C ATOM 3812 CG1 ILE A 259 −62.846 6.248 5.570 1.00 41.82 C ATOM 3815 CD1 ILE A 259 −64.029 5.872 6.508 1.00 42.29 C ATOM 3819 CG2 ILE A 259 −63.446 8.662 5.262 1.00 40.47 C ATOM 3823 C ILE A 259 −60.424 9.253 5.273 1.00 39.74 C ATOM 3824 O ILE A 259 −60.607 10.291 4.635 1.00 39.25 O ATOM 3826 N GLU A 260 −59.650 9.191 6.355 1.00 38.46 N ATOM 3827 CA GLU A 260 −58.951 10.366 6.846 1.00 37.44 C ATOM 3829 CB GLU A 260 −58.183 10.072 8.140 1.00 37.74 C ATOM 3832 CG GLU A 260 −59.041 9.934 9.393 1.00 38.71 C ATOM 3835 CD GLU A 260 −59.469 8.501 9.693 1.00 41.00 C ATOM 3836 OE1 GLU A 260 −59.273 7.594 8.842 1.00 42.70 O ATOM 3837 OE2 GLU A 260 −60.012 8.281 10.800 1.00 42.43 O ATOM 3838 C GLU A 260 −57.995 10.841 5.764 1.00 35.94 C ATOM 3839 O GLU A 260 −57.981 12.020 5.418 1.00 36.10 O ATOM 3841 N SER A 261 −57.222 9.908 5.212 1.00 34.02 N ATOM 3842 CA SER A 261 −56.263 10.229 4.152 1.00 32.47 C ATOM 3844 CB SER A 261 −55.407 9.015 3.774 1.00 32.51 C ATOM 3847 OG SER A 261 −54.253 8.940 4.584 1.00 33.14 O ATOM 3849 C SER A 261 −56.894 10.764 2.889 1.00 30.82 C ATOM 3850 O SER A 261 −56.199 11.306 2.062 1.00 30.79 O ATOM 3852 N PHE A 262 −58.194 10.589 2.713 1.00 29.25 N ATOM 3853 CA PHE A 262 −58.861 11.091 1.514 1.00 27.98 C ATOM 3855 CB PHE A 262 −60.011 10.185 1.119 1.00 27.57 C ATOM 3858 CG PHE A 262 −60.473 10.423 −.251 1.00 26.11 C ATOM 3859 CD1 PHE A 262 −59.763 9.914 −1.318 1.00 25.14 C ATOM 3861 CE1 PHE A 262 −60.169 10.147 −2.605 1.00 24.32 C ATOM 3863 CZ PHE A 262 −61.284 10.917 −2.840 1.00 24.36 C ATOM 3865 CE2 PHE A 262 −61.987 11.445 −1.785 1.00 25.23 C ATOM 3867 CD2 PHE A 262 −61.575 11.201 −.492 1.00 25.61 C ATOM 3869 C PHE A 262 −59.394 12.507 1.707 1.00 27.29 C ATOM 3870 O PHE A 262 −59.275 13.359 .821 1.00 27.39 O ATOM 3872 N TYR A 263 −60.025 12.723 2.856 1.00 26.19 N ATOM 3873 CA TYR A 263 −60.415 14.052 3.310 1.00 25.22 C ATOM 3875 CB TYR A 263 −60.975 13.942 4.735 1.00 25.21 C ATOM 3878 CG TYR A 263 −61.037 15.199 5.578 1.00 25.37 C ATOM 3879 CD1 TYR A 263 −62.020 16.152 5.385 1.00 24.95 C ATOM 3881 CE1 TYR A 263 −62.084 17.282 6.197 1.00 26.54 C ATOM 3883 CZ TYR A 263 −61.158 17.455 7.229 1.00 27.44 C ATOM 3884 OH TYR A 263 −61.186 18.567 8.059 1.00 28.97 O ATOM 3886 CE2 TYR A 263 −60.185 16.512 7.438 1.00 27.10 C ATOM 3888 CD2 TYR A 263 −60.136 15.390 6.626 1.00 26.91 C ATOM 3890 C TYR A 263 −59.190 14.946 3.238 1.00 24.29 C ATOM 3891 O TYR A 263 −59.267 16.077 2.757 1.00 24.13 O ATOM 3893 N TRP A 264 −58.055 14.415 3.682 1.00 23.01 N ATOM 3894 CA TRP A 264 −56.789 15.121 3.567 1.00 22.32 C ATOM 3896 CB TRP A 264 −55.642 14.261 4.119 1.00 22.26 C ATOM 3899 CG TRP A 264 −54.326 14.874 3.860 1.00 22.16 C ATOM 3900 CD1 TRP A 264 −53.614 14.821 2.699 1.00 22.68 C ATOM 3902 NE1 TRP A 264 −52.456 15.538 2.818 1.00 23.08 N ATOM 3904 CE2 TRP A 264 −52.407 16.083 4.072 1.00 23.07 C ATOM 3905 CD2 TRP A 264 −53.579 15.686 4.753 1.00 22.18 C ATOM 3906 CE3 TRP A 264 −53.782 16.119 6.066 1.00 22.57 C ATOM 3908 CZ3 TRP A 264 −52.824 16.925 6.657 1.00 23.43 C ATOM 3910 CH2 TRP A 264 −51.656 17.297 5.955 1.00 24.14 C ATOM 3912 CZ2 TRP A 264 −51.433 16.886 4.663 1.00 23.64 C ATOM 3914 C TRP A 264 −56.485 15.523 2.112 1.00 21.50 C ATOM 3915 O TRP A 264 −56.179 16.682 1.820 1.00 21.29 O ATOM 3917 N ALA A 265 −56.561 14.547 1.213 1.00 20.41 N ATOM 3918 CA ALA A 265 −56.242 14.760 −.187 1.00 19.63 C ATOM 3920 CB ALA A 265 −56.298 13.437 −.953 1.00 19.39 C ATOM 3924 C ALA A 265 −57.176 15.792 −.798 1.00 19.07 C ATOM 3925 O ALA A 265 −56.760 16.573 −1.633 1.00 18.99 O ATOM 3927 N VAL A 266 −58.431 15.814 −.359 1.00 18.78 N ATOM 3928 CA VAL A 266 −59.396 16.828 −.818 1.00 18.56 C ATOM 3930 CB VAL A 266 −60.839 16.541 −.278 1.00 18.41 C ATOM 3932 CG1 VAL A 266 −61.405 15.298 −.935 1.00 18.88 C ATOM 3936 CG2 VAL A 266 −61.780 17.709 −.505 1.00 17.21 C ATOM 3940 C VAL A 266 −58.947 18.257 −.450 1.00 18.43 C ATOM 3941 O VAL A 266 −59.250 19.200 −1.171 1.00 18.83 O ATOM 3943 N GLY A 267 −58.230 18.411 .663 1.00 17.96 N ATOM 3944 CA GLY A 267 −57.714 19.712 1.067 1.00 17.45 C ATOM 3947 C GLY A 267 −56.687 20.180 .070 1.00 17.20 C ATOM 3948 O GLY A 267 −56.574 21.365 −.215 1.00 17.41 O ATOM 3950 N VAL A 268 −55.959 19.219 −.480 1.00 16.88 N ATOM 3951 CA VAL A 268 −54.822 19.487 −1.319 1.00 16.62 C ATOM 3953 CB VAL A 268 −53.833 18.300 −1.290 1.00 16.19 C ATOM 3955 CG1 VAL A 268 −52.691 18.536 −2.240 1.00 15.50 C ATOM 3959 CG2 VAL A 268 −53.310 18.121 .103 1.00 15.30 C ATOM 3963 C VAL A 268 −55.262 19.788 −2.736 1.00 17.15 C ATOM 3964 O VAL A 268 −54.748 20.710 −3.350 1.00 17.12 O ATOM 3966 N ALA A 269 −56.217 19.014 −3.243 1.00 17.99 N ATOM 3967 CA ALA A 269 −56.688 19.158 −4.622 1.00 18.79 C ATOM 3969 CB ALA A 269 −55.958 18.183 −5.551 1.00 18.26 C ATOM 3973 C ALA A 269 −58.196 18.938 −4.672 1.00 19.70 C ATOM 3974 O ALA A 269 −58.665 17.834 −4.958 1.00 19.50 O ATOM 3976 N PHE A 270 −58.945 20.011 −4.417 1.00 21.09 N ATOM 3977 CA PHE A 270 −60.393 19.910 −4.211 1.00 22.32 C ATOM 3979 CB PHE A 270 −60.925 21.108 −3.404 1.00 22.49 C ATOM 3982 CG PHE A 270 −61.193 22.321 −4.246 1.00 23.31 C ATOM 3983 CD1 PHE A 270 −62.423 22.483 −4.883 1.00 24.16 C ATOM 3985 CE1 PHE A 270 −62.662 23.569 −5.683 1.00 23.84 C ATOM 3987 CZ PHE A 270 −61.675 24.497 −5.871 1.00 23.93 C ATOM 3989 CE2 PHE A 270 −60.448 24.349 −5.242 1.00 23.33 C ATOM 3991 CD2 PHE A 270 −60.213 23.268 −4.443 1.00 23.11 C ATOM 3993 C PHE A 270 −61.173 19.820 −5.515 1.00 23.21 C ATOM 3994 O PHE A 270 −62.142 19.069 −5.599 1.00 23.48 O ATOM 3996 N GLU A 271 −60.771 20.599 −6.522 1.00 24.16 N ATOM 3997 CA GLU A 271 −61.595 20.744 −7.741 1.00 25.01 C ATOM 3999 CB GLU A 271 −61.065 21.863 −8.655 1.00 25.19 C ATOM 4002 CG GLU A 271 −59.563 21.909 −8.794 1.00 27.45 C ATOM 4005 CD GLU A 271 −58.857 22.910 −7.857 1.00 30.03 C ATOM 4006 OE1 GLU A 271 −58.905 24.145 −8.147 1.00 29.41 O ATOM 4007 OE2 GLU A 271 −58.227 22.431 −6.865 1.00 30.71 O ATOM 4008 C GLU A 271 −61.799 19.391 −8.484 1.00 24.95 C ATOM 4009 O GLU A 271 −60.972 18.480 −8.352 1.00 25.70 O ATOM 4011 N PRO A 272 −62.918 19.242 −9.224 1.00 24.59 N ATOM 4012 CA PRO A 272 −63.399 17.915 −9.656 1.00 24.38 C ATOM 4014 CB PRO A 272 −64.675 18.243 −10.430 1.00 24.25 C ATOM 4017 CG PRO A 272 −65.105 19.536 −9.869 1.00 24.53 C ATOM 4020 CD PRO A 272 −63.855 20.295 −9.639 1.00 24.42 C ATOM 4023 C PRO A 272 −62.475 17.111 −10.549 1.00 24.29 C ATOM 4024 O PRO A 272 −62.406 15.886 −10.410 1.00 24.45 O ATOM 4025 N GLN A 273 −61.777 17.781 −11.462 1.00 24.13 N ATOM 4026 CA GLN A 273 −60.998 17.064 −12.461 1.00 24.13 C ATOM 4028 CB GLN A 273 −60.523 17.983 −13.567 1.00 23.84 C ATOM 4031 CG GLN A 273 −59.556 19.041 −13.117 1.00 24.37 C ATOM 4034 CD GLN A 273 −60.222 20.360 −12.775 1.00 25.22 C ATOM 4035 OE1 GLN A 273 −61.392 20.412 −12.367 1.00 25.71 O ATOM 4036 NE2 GLN A 273 −59.468 21.441 −12.932 1.00 24.95 N ATOM 4039 C GLN A 273 −59.808 16.327 −11.877 1.00 24.33 C ATOM 4040 O GLN A 273 −59.224 15.486 −12.555 1.00 24.91 O ATOM 4042 N TYR A 274 −59.462 16.607 −10.626 1.00 24.27 N ATOM 4043 CA TYR A 274 −58.211 16.119 −10.067 1.00 24.38 C ATOM 4045 CB TYR A 274 −57.639 17.180 −9.138 1.00 24.36 C ATOM 4048 CG TYR A 274 −57.066 18.398 −9.819 1.00 24.35 C ATOM 4049 CD1 TYR A 274 −56.249 18.291 −10.935 1.00 24.13 C ATOM 4051 CE1 TYR A 274 −55.716 19.409 −11.542 1.00 23.75 C ATOM 4053 CZ TYR A 274 −55.968 20.646 −11.019 1.00 24.14 C ATOM 4054 OH TYR A 274 −55.431 21.762 −11.597 1.00 24.45 O ATOM 4056 CE2 TYR A 274 −56.755 20.780 −9.903 1.00 24.92 C ATOM 4058 CD2 TYR A 274 −57.297 19.658 −9.308 1.00 24.74 C ATOM 4060 C TYR A 274 −58.319 14.796 −9.310 1.00 24.63 C ATOM 4061 O TYR A 274 −57.681 14.613 −8.276 1.00 24.47 O ATOM 4063 N SER A 275 −59.097 13.852 −9.821 1.00 25.00 N ATOM 4064 CA SER A 275 −59.254 12.575 −9.116 1.00 25.11 C ATOM 4066 CB SER A 275 −60.244 11.664 −9.842 1.00 25.14 C ATOM 4069 OG SER A 275 −61.537 12.252 −9.852 1.00 25.96 O ATOM 4071 C SER A 275 −57.907 11.885 −8.963 1.00 24.94 C ATOM 4072 O SER A 275 −57.544 11.439 −7.877 1.00 24.57 O ATOM 4074 N ASP A 276 −57.149 11.822 −10.052 1.00 25.01 N ATOM 4075 CA ASP A 276 −55.840 11.187 −9.990 1.00 24.92 C ATOM 4077 CB ASP A 276 −55.102 11.257 −11.324 1.00 25.02 C ATOM 4080 CG ASP A 276 −55.827 10.495 −12.407 1.00 26.27 C ATOM 4081 OD1 ASP A 276 −56.372 9.411 −12.080 1.00 26.65 O ATOM 4082 OD2 ASP A 276 −55.880 10.991 −13.563 1.00 28.21 O ATOM 4083 C ASP A 276 −55.026 11.798 −8.881 1.00 24.30 C ATOM 4084 O ASP A 276 −54.454 11.064 −8.099 1.00 24.64 O ATOM 4086 N CYS A 277 −55.005 13.124 −8.772 1.00 23.61 N ATOM 4087 CA CYS A 277 −54.210 13.746 −7.715 1.00 22.91 C ATOM 4089 CB CYS A 277 −54.262 15.268 −7.748 1.00 22.83 C ATOM 4092 SG CYS A 277 −53.048 15.994 −6.615 1.00 22.43 S ATOM 4094 C CYS A 277 −54.653 13.251 −6.357 1.00 22.39 C ATOM 4095 O CYS A 277 −53.822 12.833 −5.559 1.00 22.23 O ATOM 4097 N ARG A 278 −55.962 13.262 −6.115 1.00 22.01 N ATOM 4098 CA ARG A 278 −56.519 12.813 −4.829 1.00 21.40 C ATOM 4100 CB ARG A 278 −58.021 13.053 −4.753 1.00 21.07 C ATOM 4103 CG ARG A 278 −58.382 14.509 −4.754 1.00 20.39 C ATOM 4106 CD ARG A 278 −59.852 14.698 −4.527 1.00 20.05 C ATOM 4109 NE ARG A 278 −60.683 14.331 −5.675 1.00 18.86 N ATOM 4111 CZ ARG A 278 −60.993 15.144 −6.679 1.00 18.58 C ATOM 4112 NH1 ARG A 278 −60.530 16.391 −6.730 1.00 18.45 N ATOM 4115 NH2 ARG A 278 −61.775 14.702 −7.647 1.00 19.04 N ATOM 4118 C ARG A 278 −56.224 11.358 −4.530 1.00 21.12 C ATOM 4119 O ARG A 278 −55.804 11.050 −3.434 1.00 21.59 O ATOM 4121 N ASN A 279 −56.412 10.467 −5.493 1.00 20.94 N ATOM 4122 CA ASN A 279 −56.168 9.044 −5.243 1.00 21.08 C ATOM 4124 CB ASN A 279 −56.672 8.182 −6.401 1.00 21.54 C ATOM 4127 CG ASN A 279 −58.199 8.346 −6.642 1.00 23.94 C ATOM 4128 OD1 ASN A 279 −58.920 8.941 −5.823 1.00 26.47 O ATOM 4129 ND2 ASN A 279 −58.685 7.825 −7.769 1.00 25.52 N ATOM 4132 C ASN A 279 −54.699 8.798 −4.972 1.00 20.30 C ATOM 4133 O ASN A 279 −54.337 8.200 −3.977 1.00 19.95 O ATOM 4135 N SER A 280 −53.851 9.297 −5.856 1.00 20.02 N ATOM 4136 CA SER A 280 −52.409 9.335 −5.612 1.00 19.32 C ATOM 4138 CB SER A 280 −51.725 10.304 −6.580 1.00 19.35 C ATOM 4141 OG SER A 280 −50.624 9.705 −7.212 1.00 19.77 O ATOM 4143 C SER A 280 −52.122 9.745 −4.166 1.00 18.55 C ATOM 4144 O SER A 280 −51.514 8.976 −3.436 1.00 18.98 O ATOM 4146 N VAL A 281 −52.580 10.923 −3.743 1.00 17.45 N ATOM 4147 CA VAL A 281 −52.235 11.444 −2.416 1.00 17.01 C ATOM 4149 CB VAL A 281 −52.650 12.934 −2.235 1.00 17.20 C ATOM 4151 CG1 VAL A 281 −52.492 13.376 −.787 1.00 16.76 C ATOM 4155 CG2 VAL A 281 −51.826 13.847 −3.128 1.00 17.13 C ATOM 4159 C VAL A 281 −52.861 10.607 −1.301 1.00 16.82 C ATOM 4160 O VAL A 281 −52.217 10.314 −.289 1.00 16.81 O ATOM 4162 N ALA A 282 −54.118 10.225 −1.481 1.00 16.55 N ATOM 4163 CA ALA A 282 −54.774 9.304 −.559 1.00 16.31 C ATOM 4165 CB ALA A 282 −56.174 8.951 −1.060 1.00 16.08 C ATOM 4169 C ALA A 282 −53.946 8.036 −.355 1.00 16.31 C ATOM 4170 O ALA A 282 −53.671 7.653 .762 1.00 16.16 O ATOM 4172 N LYS A 283 −53.539 7.395 −1.443 1.00 16.92 N ATOM 4173 CA LYS A 283 −52.773 6.139 −1.368 1.00 17.39 C ATOM 4175 CB LYS A 283 −52.454 5.596 −2.773 1.00 17.31 C ATOM 4178 CG LYS A 283 −53.680 5.066 −3.519 1.00 17.85 C ATOM 4181 CD LYS A 283 −53.389 4.527 −4.941 1.00 18.98 C ATOM 4184 CE LYS A 283 −54.709 4.275 −5.718 1.00 19.79 C ATOM 4187 NZ LYS A 283 −54.695 3.091 −6.625 1.00 20.11 N ATOM 4191 C LYS A 283 −51.483 6.338 −.591 1.00 17.82 C ATOM 4192 O LYS A 283 −51.170 5.577 .331 1.00 17.37 O ATOM 4194 N MET A 284 −50.744 7.381 −.964 1.00 18.49 N ATOM 4195 CA MET A 284 −49.434 7.622 −.373 1.00 18.82 C ATOM 4197 CB MET A 284 −48.688 8.795 −1.047 1.00 18.84 C ATOM 4200 CG MET A 284 −48.118 8.506 −2.444 1.00 18.47 C ATOM 4203 SD MET A 284 −47.540 6.819 −2.718 1.00 19.50 S ATOM 4204 CE MET A 284 −49.088 5.982 −3.094 1.00 19.36 C ATOM 4208 C MET A 284 −49.575 7.848 1.115 1.00 18.95 C ATOM 4209 O MET A 284 −48.901 7.166 1.892 1.00 19.29 O ATOM 4211 N PHE A 285 −50.465 8.762 1.507 1.00 18.94 N ATOM 4212 CA PHE A 285 −50.671 9.082 2.930 1.00 19.26 C ATOM 4214 CB PHE A 285 −51.714 10.185 3.073 1.00 19.72 C ATOM 4217 CG PHE A 285 −51.575 11.016 4.328 1.00 21.97 C ATOM 4218 CD1 PHE A 285 −50.335 11.202 4.954 1.00 24.49 C ATOM 4220 CE1 PHE A 285 −50.209 11.996 6.086 1.00 25.11 C ATOM 4222 CZ PHE A 285 −51.321 12.634 6.597 1.00 26.40 C ATOM 4224 CE2 PHE A 285 −52.566 12.470 5.977 1.00 26.44 C ATOM 4226 CD2 PHE A 285 −52.678 11.670 4.846 1.00 24.55 C ATOM 4228 C PHE A 285 −51.097 7.879 3.770 1.00 18.74 C ATOM 4229 O PHE A 285 −50.700 7.729 4.924 1.00 18.31 O ATOM 4231 N SER A 286 −51.903 7.019 3.169 1.00 18.49 N ATOM 4232 CA SER A 286 −52.281 5.772 3.791 1.00 18.38 C ATOM 4234 CB SER A 286 −53.302 5.065 2.926 1.00 18.45 C ATOM 4237 OG SER A 286 −54.389 5.949 2.687 1.00 19.82 O ATOM 4239 C SER A 286 −51.070 4.888 4.048 1.00 18.08 C ATOM 4240 O SER A 286 −50.931 4.376 5.146 1.00 18.18 O ATOM 4242 N PHE A 287 −50.195 4.714 3.054 1.00 17.72 N ATOM 4243 CA PHE A 287 −48.911 4.024 3.279 1.00 17.23 C ATOM 4245 CB PHE A 287 −48.133 3.801 1.977 1.00 17.09 C ATOM 4248 CG PHE A 287 −48.513 2.555 1.258 1.00 17.26 C ATOM 4249 CD1 PHE A 287 −48.220 1.315 1.802 1.00 18.31 C ATOM 4251 CE1 PHE A 287 −48.583 .129 1.131 1.00 18.47 C ATOM 4253 CZ PHE A 287 −49.237 .198 −.091 1.00 17.88 C ATOM 4255 CE2 PHE A 287 −49.530 1.441 −.642 1.00 17.57 C ATOM 4257 CD2 PHE A 287 −49.168 2.608 .031 1.00 17.79 C ATOM 4259 C PHE A 287 −48.022 4.787 4.277 1.00 16.92 C ATOM 4260 O PHE A 287 −47.369 4.173 5.143 1.00 17.18 O ATOM 4262 N VAL A 288 −47.989 6.113 4.174 1.00 16.00 N ATOM 4263 CA VAL A 288 −47.148 6.883 5.080 1.00 15.45 C ATOM 4265 CB VAL A 288 −47.289 8.399 4.863 1.00 15.21 C ATOM 4267 CG1 VAL A 288 −46.433 9.162 5.852 1.00 14.24 C ATOM 4271 CG2 VAL A 288 −46.898 8.757 3.450 1.00 14.46 C ATOM 4275 C VAL A 288 −47.479 6.499 6.527 1.00 15.46 C ATOM 4276 O VAL A 288 −46.590 6.160 7.299 1.00 14.79 O ATOM 4278 N THR A 289 −48.759 6.494 6.880 1.00 15.62 N ATOM 4279 CA THR A 289 −49.110 6.272 8.274 1.00 16.09 C ATOM 4281 CB THR A 289 −50.602 6.557 8.588 1.00 15.72 C ATOM 4283 OG1 THR A 289 −51.422 5.827 7.708 1.00 16.52 O ATOM 4285 CG2 THR A 289 −50.927 8.007 8.371 1.00 16.56 C ATOM 4289 C THR A 289 −48.677 4.879 8.727 1.00 16.34 C ATOM 4290 O THR A 289 −48.234 4.707 9.881 1.00 16.68 O ATOM 4292 N ILE A 290 −48.737 3.904 7.820 1.00 16.29 N ATOM 4293 CA ILE A 290 −48.347 2.538 8.166 1.00 16.56 C ATOM 4295 CB ILE A 290 −48.734 1.516 7.096 1.00 16.48 C ATOM 4297 CG1 ILE A 290 −50.247 1.440 6.944 1.00 16.91 C ATOM 4300 CD1 ILE A 290 −50.677 .564 5.811 1.00 16.52 C ATOM 4304 CG2 ILE A 290 −48.262 .145 7.488 1.00 16.52 C ATOM 4308 C ILE A 290 −46.842 2.456 8.402 1.00 16.94 C ATOM 4309 O ILE A 290 −46.404 1.968 9.443 1.00 17.06 O ATOM 4311 N ILE A 291 −46.048 2.942 7.451 1.00 17.22 N ATOM 4312 CA ILE A 291 −44.595 2.969 7.640 1.00 17.20 C ATOM 4314 CB ILE A 291 −43.842 3.534 6.405 1.00 17.32 C ATOM 4316 CG1 ILE A 291 −44.172 2.744 5.125 1.00 17.61 C ATOM 4319 CD1 ILE A 291 −44.004 1.265 5.250 1.00 18.21 C ATOM 4323 CG2 ILE A 291 −42.336 3.550 6.637 1.00 16.64 C ATOM 4327 C ILE A 291 −44.262 3.794 8.886 1.00 17.36 C ATOM 4328 O ILE A 291 −43.420 3.413 9.670 1.00 17.06 O ATOM 4330 N ASP A 292 −44.950 4.906 9.093 1.00 18.12 N ATOM 4331 CA ASP A 292 −44.627 5.755 10.227 1.00 18.83 C ATOM 4333 CB ASP A 292 −45.511 7.017 10.285 1.00 19.22 C ATOM 4336 CG ASP A 292 −45.185 7.920 11.485 1.00 19.93 C ATOM 4337 OD1 ASP A 292 −44.062 8.460 11.544 1.00 21.80 O ATOM 4338 OD2 ASP A 292 −46.048 8.080 12.375 1.00 20.46 O ATOM 4339 C ASP A 292 −44.745 4.947 11.509 1.00 18.96 C ATOM 4340 O ASP A 292 −43.902 5.094 12.394 1.00 19.05 O ATOM 4342 N ASP A 293 −45.774 4.097 11.610 1.00 19.05 N ATOM 4343 CA ASP A 293 −45.951 3.273 12.817 1.00 18.99 C ATOM 4345 CB ASP A 293 −47.237 2.443 12.790 1.00 18.95 C ATOM 4348 CG ASP A 293 −48.496 3.272 12.921 1.00 19.27 C ATOM 4349 OD1 ASP A 293 −48.483 4.361 13.523 1.00 21.51 O ATOM 4350 OD2 ASP A 293 −49.536 2.812 12.421 1.00 19.61 O ATOM 4351 C ASP A 293 −44.783 2.322 12.935 1.00 19.07 C ATOM 4352 O ASP A 293 −44.244 2.135 14.024 1.00 19.35 O ATOM 4354 N ILE A 294 −44.390 1.730 11.805 1.00 19.10 N ATOM 4355 CA ILE A 294 −43.320 .727 11.786 1.00 19.04 C ATOM 4357 CB ILE A 294 −43.137 .109 10.386 1.00 18.49 C ATOM 4359 CG1 ILE A 294 −44.343 −.754 10.038 1.00 17.60 C ATOM 4362 CD1 ILE A 294 −44.204 −1.504 8.752 1.00 16.77 C ATOM 4366 CG2 ILE A 294 −41.895 −.745 10.348 1.00 18.77 C ATOM 4370 C ILE A 294 −41.974 1.273 12.298 1.00 19.55 C ATOM 4371 O ILE A 294 −41.234 .550 12.974 1.00 19.75 O ATOM 4373 N TYR A 295 −41.649 2.525 11.983 1.00 19.75 N ATOM 4374 CA TYR A 295 −40.411 3.103 12.476 1.00 19.91 C ATOM 4376 CB TYR A 295 −39.856 4.178 11.542 1.00 19.66 C ATOM 4379 CG TYR A 295 −39.206 3.695 10.245 1.00 18.19 C ATOM 4380 CD1 TYR A 295 −37.821 3.727 10.075 1.00 16.19 C ATOM 4382 CE1 TYR A 295 −37.222 3.331 8.882 1.00 14.68 C ATOM 4384 CZ TYR A 295 −38.004 2.906 7.828 1.00 15.04 C ATOM 4385 OH TYR A 295 −37.428 2.485 6.631 1.00 12.25 O ATOM 4387 CE2 TYR A 295 −39.383 2.871 7.975 1.00 16.48 C ATOM 4389 CD2 TYR A 295 −39.975 3.271 9.172 1.00 17.01 C ATOM 4391 C TYR A 295 −40.647 3.677 13.858 1.00 20.73 C ATOM 4392 O TYR A 295 −39.749 3.635 14.717 1.00 21.64 O ATOM 4394 N ASP A 296 −41.843 4.200 14.103 1.00 21.38 N ATOM 4395 CA ASP A 296 −42.100 4.865 15.391 1.00 22.20 C ATOM 4397 CB ASP A 296 −43.421 5.644 15.391 1.00 22.69 C ATOM 4400 CG ASP A 296 −43.567 6.548 16.607 1.00 23.85 C ATOM 4401 OD1 ASP A 296 −42.568 7.179 17.014 1.00 25.49 O ATOM 4402 OD2 ASP A 296 −44.689 6.648 17.145 1.00 26.12 O ATOM 4403 C ASP A 296 −42.106 3.890 16.549 1.00 22.10 C ATOM 4404 O ASP A 296 −41.376 4.082 17.506 1.00 22.14 O ATOM 4406 N VAL A 297 −42.900 2.828 16.435 1.00 22.25 N ATOM 4407 CA VAL A 297 −43.163 1.937 17.570 1.00 22.22 C ATOM 4409 CB VAL A 297 −44.635 2.116 18.057 1.00 22.07 C ATOM 4411 CG1 VAL A 297 −44.958 3.587 18.215 1.00 21.63 C ATOM 4415 CG2 VAL A 297 −45.618 1.459 17.099 1.00 20.76 C ATOM 4419 C VAL A 297 −42.861 .422 17.373 1.00 22.49 C ATOM 4420 O VAL A 297 −42.517 −.255 18.343 1.00 22.40 O ATOM 4422 N TYR A 298 −42.990 −.117 16.157 1.00 22.69 N ATOM 4423 CA TYR A 298 −43.065 −1.579 15.993 1.00 22.90 C ATOM 4425 CB TYR A 298 −44.089 −1.974 14.934 1.00 22.77 C ATOM 4428 CG TYR A 298 −44.341 −3.469 14.932 1.00 23.74 C ATOM 4429 CD1 TYR A 298 −45.249 −4.043 15.819 1.00 25.72 C ATOM 4431 CE1 TYR A 298 −45.484 −5.435 15.833 1.00 26.12 C ATOM 4433 CZ TYR A 298 −44.798 −6.247 14.954 1.00 25.59 C ATOM 4434 OH TYR A 298 −45.027 −7.593 14.970 1.00 25.33 O ATOM 4436 CE2 TYR A 298 −43.890 −5.702 14.062 1.00 24.79 C ATOM 4438 CD2 TYR A 298 −43.661 −4.317 14.061 1.00 24.20 C ATOM 4440 C TYR A 298 −41.750 −2.258 15.649 1.00 23.02 C ATOM 4441 O TYR A 298 −41.387 −3.257 16.256 1.00 22.80 O ATOM 4443 N GLY A 299 −41.069 −1.747 14.634 1.00 23.47 N ATOM 4444 CA GLY A 299 −39.839 −2.361 14.149 1.00 23.36 C ATOM 4447 C GLY A 299 −38.631 −1.978 14.984 1.00 23.27 C ATOM 4448 O GLY A 299 −38.532 −.858 15.501 1.00 23.35 O ATOM 4450 N THR A 300 −37.702 −2.918 15.098 1.00 23.11 N ATOM 4451 CA THR A 300 −36.459 −2.682 15.797 1.00 22.90 C ATOM 4453 CB THR A 300 −35.869 −3.957 16.386 1.00 22.83 C ATOM 4455 OG1 THR A 300 −35.328 −4.756 15.328 1.00 22.61 O ATOM 4457 CG2 THR A 300 −36.928 −4.732 17.162 1.00 22.18 C ATOM 4461 C THR A 300 −35.482 −2.120 14.796 1.00 23.00 C ATOM 4462 O THR A 300 −35.606 −2.364 13.602 1.00 23.13 O ATOM 4464 N LEU A 301 −34.496 −1.394 15.309 1.00 23.07 N ATOM 4465 CA LEU A 301 −33.596 −.572 14.498 1.00 22.84 C ATOM 4467 CB LEU A 301 −32.515 .007 15.403 1.00 22.80 C ATOM 4470 CG LEU A 301 −31.965 1.412 15.182 1.00 22.39 C ATOM 4472 CD1 LEU A 301 −32.983 2.365 14.587 1.00 22.44 C ATOM 4476 CD2 LEU A 301 −31.482 1.919 16.536 1.00 22.19 C ATOM 4480 C LEU A 301 −32.964 −1.358 13.361 1.00 22.95 C ATOM 4481 O LEU A 301 −32.910 −.888 12.232 1.00 22.50 O ATOM 4483 N ASP A 302 −32.511 −2.569 13.673 1.00 23.35 N ATOM 4484 CA ASP A 302 −31.929 −3.469 12.670 1.00 23.65 C ATOM 4486 CB ASP A 302 −31.332 −4.747 13.328 1.00 24.12 C ATOM 4489 CG ASP A 302 −29.984 −4.498 14.057 1.00 25.23 C ATOM 4490 OD1 ASP A 302 −29.003 −4.051 13.409 1.00 26.43 O ATOM 4491 OD2 ASP A 302 −29.896 −4.780 15.277 1.00 26.92 O ATOM 4492 C ASP A 302 −32.945 −3.859 11.581 1.00 23.11 C ATOM 4493 O ASP A 302 −32.544 −4.086 10.445 1.00 23.05 O ATOM 4495 N GLU A 303 −34.235 −3.965 11.927 1.00 22.63 N ATOM 4496 CA GLU A 303 −35.295 −4.248 10.931 1.00 22.40 C ATOM 4498 CB GLU A 303 −36.625 −4.675 11.589 1.00 22.20 C ATOM 4501 CG GLU A 303 −36.537 −5.956 12.426 1.00 22.66 C ATOM 4504 CD GLU A 303 −37.832 −6.341 13.159 1.00 22.69 C ATOM 4505 OE1 GLU A 303 −38.614 −5.449 13.568 1.00 22.23 O ATOM 4506 OE2 GLU A 303 −38.051 −7.558 13.338 1.00 21.64 O ATOM 4507 C GLU A 303 −35.533 −3.017 10.067 1.00 22.35 C ATOM 4508 O GLU A 303 −35.658 −3.105 8.841 1.00 22.27 O ATOM 4510 N LEU A 304 −35.597 −1.866 10.724 1.00 22.34 N ATOM 4511 CA LEU A 304 −35.776 −.607 10.040 1.00 22.26 C ATOM 4513 CB LEU A 304 −35.861 .537 11.052 1.00 22.49 C ATOM 4516 CG LEU A 304 −37.089 .517 11.973 1.00 23.05 C ATOM 4518 CD1 LEU A 304 −37.109 1.708 12.932 1.00 23.46 C ATOM 4522 CD2 LEU A 304 −38.353 .511 11.142 1.00 23.96 C ATOM 4526 C LEU A 304 −34.634 −.383 9.063 1.00 22.09 C ATOM 4527 O LEU A 304 −34.873 .094 7.969 1.00 22.32 O ATOM 4529 N GLU A 305 −33.408 −.740 9.450 1.00 21.91 N ATOM 4530 CA GLU A 305 −32.259 −.685 8.541 1.00 21.93 C ATOM 4532 CB GLU A 305 −30.988 −1.194 9.219 1.00 22.35 C ATOM 4535 CG GLU A 305 −30.363 −.258 10.249 1.00 24.12 C ATOM 4538 CD GLU A 305 −29.751 1.002 9.649 1.00 26.11 C ATOM 4539 OE1 GLU A 305 −29.275 1.846 10.454 1.00 25.68 O ATOM 4540 OE2 GLU A 305 −29.756 1.146 8.391 1.00 27.67 O ATOM 4541 C GLU A 305 −32.475 −1.524 7.295 1.00 21.54 C ATOM 4542 O GLU A 305 −32.010 −1.162 6.220 1.00 21.75 O ATOM 4544 N LEU A 306 −33.155 −2.660 7.448 1.00 21.21 N ATOM 4545 CA LEU A 306 −33.459 −3.557 6.316 1.00 20.66 C ATOM 4547 CB LEU A 306 −33.880 −4.956 6.795 1.00 20.26 C ATOM 4550 CG LEU A 306 −32.725 −5.854 7.220 1.00 19.57 C ATOM 4552 CD1 LEU A 306 −33.261 −7.150 7.777 1.00 20.18 C ATOM 4556 CD2 LEU A 306 −31.791 −6.120 6.061 1.00 18.29 C ATOM 4560 C LEU A 306 −34.535 −2.967 5.416 1.00 20.23 C ATOM 4561 O LEU A 306 −34.412 −2.966 4.197 1.00 19.97 O ATOM 4563 N PHE A 307 −35.588 −2.457 6.023 1.00 19.99 N ATOM 4564 CA PHE A 307 −36.635 −1.861 5.237 1.00 20.00 C ATOM 4566 CB PHE A 307 −37.771 −1.388 6.118 1.00 20.08 C ATOM 4569 CG PHE A 307 −39.011 −1.115 5.370 1.00 19.05 C ATOM 4570 CD1 PHE A 307 −39.895 −2.118 5.119 1.00 18.77 C ATOM 4572 CE1 PHE A 307 −41.037 −1.873 4.421 1.00 20.07 C ATOM 4574 CZ PHE A 307 −41.296 −.621 3.959 1.00 19.63 C ATOM 4576 CE2 PHE A 307 −40.411 .391 4.199 1.00 19.27 C ATOM 4578 CD2 PHE A 307 −39.278 .142 4.900 1.00 19.17 C ATOM 4580 C PHE A 307 −36.087 −.695 4.447 1.00 20.25 C ATOM 4581 O PHE A 307 −36.356 −.589 3.242 1.00 20.08 O ATOM 4583 N THR A 308 −35.325 .167 5.137 1.00 20.51 N ATOM 4584 CA THR A 308 −34.737 1.379 4.538 1.00 20.60 C ATOM 4586 CB THR A 308 −33.860 2.177 5.541 1.00 20.41 C ATOM 4588 OG1 THR A 308 −34.672 2.661 6.611 1.00 20.05 O ATOM 4590 CG2 THR A 308 −33.198 3.376 4.864 1.00 20.38 C ATOM 4594 C THR A 308 −33.895 1.009 3.331 1.00 20.82 C ATOM 4595 O THR A 308 −34.057 1.571 2.243 1.00 20.45 O ATOM 4597 N ASP A 309 −33.020 .031 3.522 1.00 21.32 N ATOM 4598 CA ASP A 309 −32.138 −.399 2.449 1.00 21.88 C ATOM 4600 CB ASP A 309 −31.042 −1.324 2.971 1.00 22.44 C ATOM 4603 CG ASP A 309 −30.164 −1.847 1.857 1.00 25.69 C ATOM 4604 OD1 ASP A 309 −29.599 −1.010 1.089 1.00 28.02 O ATOM 4605 OD2 ASP A 309 −30.076 −3.100 1.730 1.00 30.59 O ATOM 4606 C ASP A 309 −32.928 −1.085 1.357 1.00 21.17 C ATOM 4607 O ASP A 309 −32.601 −.948 .188 1.00 20.95 O ATOM 4609 N ALA A 310 −33.965 −1.818 1.757 1.00 20.99 N ATOM 4610 CA ALA A 310 −34.885 −2.474 .828 1.00 20.91 C ATOM 4612 CB ALA A 310 −35.931 −3.244 1.591 1.00 20.77 C ATOM 4616 C ALA A 310 −35.567 −1.501 −.123 1.00 21.08 C ATOM 4617 O ALA A 310 −35.745 −1.816 −1.305 1.00 20.76 O ATOM 4619 N VAL A 311 −35.958 −.334 .402 1.00 21.51 N ATOM 4620 CA VAL A 311 −36.594 .719 −.396 1.00 21.50 C ATOM 4622 CB VAL A 311 −37.424 1.715 .477 1.00 21.73 C ATOM 4624 CG1 VAL A 311 −38.724 1.076 .941 1.00 21.01 C ATOM 4628 CG2 VAL A 311 −37.765 2.993 −.292 1.00 21.88 C ATOM 4632 C VAL A 311 −35.553 1.445 −1.230 1.00 21.67 C ATOM 4633 O VAL A 311 −35.811 1.728 −2.389 1.00 21.71 O ATOM 4635 N GLU A 312 −34.381 1.724 −.663 1.00 22.25 N ATOM 4636 CA GLU A 312 −33.248 2.284 −1.443 1.00 23.00 C ATOM 4638 CB GLU A 312 −31.951 2.331 −.608 1.00 23.36 C ATOM 4641 CG GLU A 312 −31.897 3.383 .511 1.00 24.72 C ATOM 4644 CD GLU A 312 −30.526 3.469 1.189 1.00 27.09 C ATOM 4645 OE1 GLU A 312 −30.083 4.608 1.458 1.00 30.07 O ATOM 4646 OE2 GLU A 312 −29.885 2.418 1.454 1.00 27.86 O ATOM 4647 C GLU A 312 −32.954 1.498 −2.731 1.00 23.13 C ATOM 4648 O GLU A 312 −32.851 2.064 −3.803 1.00 22.88 O ATOM 4650 N ARG A 313 −32.819 .188 −2.615 1.00 23.74 N ATOM 4651 CA ARG A 313 −32.400 −.628 −3.743 1.00 24.46 C ATOM 4653 CB ARG A 313 −31.758 −1.916 −3.232 1.00 25.01 C ATOM 4656 CG ARG A 313 −30.421 −1.667 −2.481 1.00 27.74 C ATOM 4659 CD ARG A 313 −29.715 −2.963 −2.072 1.00 31.41 C ATOM 4662 NE ARG A 313 −30.675 −3.921 −1.499 1.00 34.94 N ATOM 4664 CZ ARG A 313 −31.203 −4.974 −2.138 1.00 37.87 C ATOM 4665 NH1 ARG A 313 −30.861 −5.282 −3.402 1.00 38.35 N ATOM 4668 NH2 ARG A 313 −32.079 −5.746 −1.495 1.00 38.82 N ATOM 4671 C ARG A 313 −33.523 −.914 −4.739 1.00 24.27 C ATOM 4672 O ARG A 313 −33.257 −1.178 −5.898 1.00 24.17 O ATOM 4674 N TRP A 314 −34.770 −.873 −4.282 1.00 24.59 N ATOM 4675 CA TRP A 314 −35.939 −1.042 −5.142 1.00 24.66 C ATOM 4677 CB TRP A 314 −36.175 .234 −5.961 1.00 24.39 C ATOM 4680 CG TRP A 314 −37.575 .382 −6.386 1.00 22.61 C ATOM 4681 CD1 TRP A 314 −38.073 .204 −7.635 1.00 21.66 C ATOM 4683 NE1 TRP A 314 −39.429 .403 −7.634 1.00 21.42 N ATOM 4685 CE2 TRP A 314 −39.829 .707 −6.360 1.00 20.99 C ATOM 4686 CD2 TRP A 314 −38.683 .701 −5.550 1.00 21.41 C ATOM 4687 CE3 TRP A 314 −38.817 .991 −4.191 1.00 21.48 C ATOM 4689 CZ3 TRP A 314 −40.080 1.277 −3.693 1.00 21.38 C ATOM 4691 CH2 TRP A 314 −41.204 1.269 −4.523 1.00 20.84 C ATOM 4693 CZ2 TRP A 314 −41.099 .985 −5.857 1.00 20.87 C ATOM 4695 C TRP A 314 −35.831 −2.286 −6.038 1.00 25.65 C ATOM 4696 O TRP A 314 −36.069 −2.238 −7.259 1.00 25.69 O ATOM 4698 N ASP A 315 −35.480 −3.400 −5.404 1.00 26.79 N ATOM 4699 CA ASP A 315 −35.253 −4.667 −6.087 1.00 28.01 C ATOM 4701 CB ASP A 315 −33.801 −5.097 −5.890 1.00 28.07 C ATOM 4704 CG ASP A 315 −33.553 −6.536 −6.296 1.00 29.92 C ATOM 4705 OD1 ASP A 315 −34.262 −7.026 −7.197 1.00 32.58 O ATOM 4706 OD2 ASP A 315 −32.648 −7.194 −5.722 1.00 32.73 O ATOM 4707 C ASP A 315 −36.202 −5.710 −5.518 1.00 28.91 C ATOM 4708 O ASP A 315 −36.019 −6.163 −4.399 1.00 29.17 O ATOM 4710 N VAL A 316 −37.218 −6.091 −6.283 1.00 30.25 N ATOM 4711 CA VAL A 316 −38.233 −7.012 −5.778 1.00 31.47 C ATOM 4713 CB VAL A 316 −39.396 −7.156 −6.755 1.00 31.56 C ATOM 4715 CG1 VAL A 316 −40.668 −7.590 −6.027 1.00 30.99 C ATOM 4719 CG2 VAL A 316 −39.033 −8.141 −7.862 1.00 31.84 C ATOM 4723 C VAL A 316 −37.663 −8.405 −5.540 1.00 32.86 C ATOM 4724 O VAL A 316 −38.170 −9.153 −4.708 1.00 32.99 O ATOM 4726 N ASN A 317 −36.607 −8.750 −6.278 1.00 34.55 N ATOM 4727 CA ASN A 317 −35.940 −10.060 −6.160 1.00 35.53 C ATOM 4729 CB ASN A 317 −35.013 −10.298 −7.367 1.00 35.68 C ATOM 4732 CG ASN A 317 −35.752 −10.264 −8.713 1.00 35.92 C ATOM 4733 OD1 ASN A 317 −36.634 −11.092 −8.971 1.00 36.95 O ATOM 4734 ND2 ASN A 317 −35.368 −9.323 −9.585 1.00 34.17 N ATOM 4737 C ASN A 317 −35.126 −10.225 −4.871 1.00 36.40 C ATOM 4738 O ASN A 317 −34.385 −11.195 −4.747 1.00 36.47 O ATOM 4740 N ALA A 318 −35.239 −9.265 −3.944 1.00 37.52 N ATOM 4741 CA ALA A 318 −34.614 −9.335 −2.613 1.00 38.45 C ATOM 4743 CB ALA A 318 −33.371 −8.465 −2.557 1.00 38.43 C ATOM 4747 C ALA A 318 −35.631 −8.902 −1.554 1.00 39.28 C ATOM 4748 O ALA A 318 −35.361 −8.094 −.662 1.00 39.55 O ATOM 4750 N ILE A 319 −36.823 −9.456 −1.698 1.00 40.17 N ATOM 4751 CA ILE A 319 −37.905 −9.310 −.740 1.00 40.49 C ATOM 4753 CB ILE A 319 −39.275 −9.588 −1.469 1.00 40.64 C ATOM 4755 CG1 ILE A 319 −40.473 −9.078 −.683 1.00 40.88 C ATOM 4758 CD1 ILE A 319 −41.799 −9.535 −1.280 1.00 40.86 C ATOM 4762 CG2 ILE A 319 −39.460 −11.082 −1.801 1.00 40.50 C ATOM 4766 C ILE A 319 −37.656 −10.319 .393 1.00 40.69 C ATOM 4767 O ILE A 319 −38.136 −10.138 1.504 1.00 40.88 O ATOM 4769 N ASN A 320 −36.886 −11.374 .104 1.00 40.79 N ATOM 4770 CA ASN A 320 −36.689 −12.483 1.049 1.00 40.64 C ATOM 4772 CB ASN A 320 −36.240 −13.761 .314 1.00 40.73 C ATOM 4775 CG ASN A 320 −37.370 −14.422 −.468 1.00 40.98 C ATOM 4776 OD1 ASN A 320 −38.556 −14.309 −.119 1.00 40.77 O ATOM 4777 ND2 ASN A 320 −37.001 −15.131 −1.529 1.00 41.31 N ATOM 4780 C ASN A 320 −35.711 −12.175 2.169 1.00 40.16 C ATOM 4781 O ASN A 320 −35.546 −12.978 3.077 1.00 40.15 O ATOM 4783 N ASP A 321 −35.067 −11.017 2.101 1.00 39.66 N ATOM 4784 CA ASP A 321 −34.111 −10.615 3.126 1.00 39.51 C ATOM 4786 CB ASP A 321 −33.114 −9.571 2.575 1.00 40.17 C ATOM 4789 CG ASP A 321 −32.595 −9.904 1.152 1.00 42.12 C ATOM 4790 OD1 ASP A 321 −32.425 −11.115 .820 1.00 44.15 O ATOM 4791 OD2 ASP A 321 −32.354 −8.934 .375 1.00 43.28 O ATOM 4792 C ASP A 321 −34.851 −10.030 4.337 1.00 38.27 C ATOM 4793 O ASP A 321 −34.304 −9.987 5.443 1.00 38.15 O ATOM 4795 N LEU A 322 −36.089 −9.583 4.108 1.00 36.72 N ATOM 4796 CA LEU A 322 −36.887 −8.875 5.104 1.00 35.38 C ATOM 4798 CB LEU A 322 −37.894 −7.942 4.422 1.00 35.15 C ATOM 4801 CG LEU A 322 −37.370 −6.840 3.503 1.00 34.83 C ATOM 4803 CD1 LEU A 322 −38.479 −6.286 2.626 1.00 34.45 C ATOM 4807 CD2 LEU A 322 −36.742 −5.740 4.316 1.00 34.89 C ATOM 4811 C LEU A 322 −37.683 −9.834 5.963 1.00 34.57 C ATOM 4812 O LEU A 322 −37.975 −10.933 5.527 1.00 34.27 O ATOM 4814 N PRO A 323 −38.039 −9.402 7.189 1.00 33.93 N ATOM 4815 CA PRO A 323 −39.070 −9.917 8.067 1.00 33.49 C ATOM 4817 CB PRO A 323 −39.151 −8.840 9.141 1.00 33.31 C ATOM 4820 CG PRO A 323 −37.791 −8.419 9.311 1.00 33.67 C ATOM 4823 CD PRO A 323 −37.154 −8.496 7.941 1.00 34.20 C ATOM 4826 C PRO A 323 −40.429 −10.036 7.425 1.00 33.33 C ATOM 4827 O PRO A 323 −40.776 −9.232 6.579 1.00 33.35 O ATOM 4828 N ASP A 324 −41.209 −11.005 7.891 1.00 33.37 N ATOM 4829 CA ASP A 324 −42.511 −11.329 7.313 1.00 33.36 C ATOM 4831 CB ASP A 324 −43.137 −12.542 8.037 1.00 33.59 C ATOM 4834 CG ASP A 324 −42.496 −13.881 7.619 1.00 34.18 C ATOM 4835 OD1 ASP A 324 −41.885 −13.915 6.518 1.00 36.44 O ATOM 4836 OD2 ASP A 324 −42.607 −14.887 8.371 1.00 32.19 O ATOM 4837 C ASP A 324 −43.484 −10.149 7.289 1.00 32.90 C ATOM 4838 O ASP A 324 −44.108 −9.885 6.255 1.00 33.36 O ATOM 4840 N TYR A 325 −43.606 −9.423 8.392 1.00 32.10 N ATOM 4841 CA TYR A 325 −44.515 −8.279 8.400 1.00 31.65 C ATOM 4843 CB TYR A 325 −44.718 −7.726 9.815 1.00 31.68 C ATOM 4846 CG TYR A 325 −43.618 −6.846 10.352 1.00 31.35 C ATOM 4847 CD1 TYR A 325 −42.507 −7.389 10.992 1.00 31.31 C ATOM 4849 CE1 TYR A 325 −41.497 −6.574 11.504 1.00 31.46 C ATOM 4851 CZ TYR A 325 −41.613 −5.192 11.392 1.00 32.41 C ATOM 4852 OH TYR A 325 −40.637 −4.336 11.893 1.00 32.78 O ATOM 4854 CE2 TYR A 325 −42.723 −4.644 10.769 1.00 32.17 C ATOM 4856 CD2 TYR A 325 −43.713 −5.470 10.261 1.00 31.47 C ATOM 4858 C TYR A 325 −44.094 −7.179 7.424 1.00 31.17 C ATOM 4859 O TYR A 325 −44.947 −6.458 6.920 1.00 31.09 O ATOM 4861 N MET A 326 −42.796 −7.068 7.145 1.00 30.73 N ATOM 4862 CA MET A 326 −42.277 −6.036 6.225 1.00 30.49 C ATOM 4864 CB MET A 326 −40.832 −5.702 6.565 1.00 30.16 C ATOM 4867 CG MET A 326 −40.725 −4.918 7.830 1.00 29.57 C ATOM 4870 SD MET A 326 −39.057 −4.376 8.166 1.00 28.39 S ATOM 4871 CE MET A 326 −39.407 −2.787 8.933 1.00 26.18 C ATOM 4875 C MET A 326 −42.371 −6.418 4.748 1.00 30.59 C ATOM 4876 O MET A 326 −42.786 −5.603 3.920 1.00 30.48 O ATOM 4878 N LYS A 327 −41.936 −7.643 4.438 1.00 30.68 N ATOM 4879 CA LYS A 327 −42.170 −8.299 3.143 1.00 30.56 C ATOM 4881 CB LYS A 327 −42.267 −9.830 3.326 1.00 30.84 C ATOM 4884 CG LYS A 327 −41.052 −10.607 2.844 1.00 32.35 C ATOM 4887 CD LYS A 327 −40.990 −12.019 3.412 1.00 34.43 C ATOM 4890 CE LYS A 327 −40.221 −12.941 2.462 1.00 35.77 C ATOM 4893 NZ LYS A 327 −39.691 −14.162 3.150 1.00 37.20 N ATOM 4897 C LYS A 327 −43.453 −7.811 2.515 1.00 29.89 C ATOM 4898 O LYS A 327 −43.447 −7.220 1.436 1.00 29.85 O ATOM 4900 N LEU A 328 −44.544 −8.046 3.230 1.00 29.10 N ATOM 4901 CA LEU A 328 −45.871 −7.781 2.730 1.00 28.77 C ATOM 4903 CB LEU A 328 −46.899 −8.336 3.709 1.00 28.81 C ATOM 4906 CG LEU A 328 −48.349 −8.364 3.257 1.00 28.82 C ATOM 4908 CD1 LEU A 328 −48.519 −9.260 2.046 1.00 29.09 C ATOM 4912 CD2 LEU A 328 −49.202 −8.845 4.411 1.00 29.16 C ATOM 4916 C LEU A 328 −46.057 −6.291 2.564 1.00 28.61 C ATOM 4917 O LEU A 328 −46.582 −5.828 1.554 1.00 29.00 O ATOM 4919 N CYS A 329 −45.612 −5.532 3.557 1.00 28.24 N ATOM 4920 CA CYS A 329 −45.737 −4.086 3.504 1.00 27.95 C ATOM 4922 CB CYS A 329 −45.311 −3.459 4.834 1.00 28.21 C ATOM 4925 SG CYS A 329 −45.280 −1.630 4.817 1.00 32.39 S ATOM 4927 C CYS A 329 −44.921 −3.541 2.327 1.00 26.34 C ATOM 4928 O CYS A 329 −45.459 −2.853 1.475 1.00 26.23 O ATOM 4930 N PHE A 330 −43.642 −3.882 2.269 1.00 24.82 N ATOM 4931 CA PHE A 330 −42.790 −3.514 1.130 1.00 23.82 C ATOM 4933 CB PHE A 330 −41.397 −4.137 1.283 1.00 23.64 C ATOM 4936 CG PHE A 330 −40.492 −3.873 .117 1.00 22.63 C ATOM 4937 CD1 PHE A 330 −39.845 −2.658 −.008 1.00 21.68 C ATOM 4939 CE1 PHE A 330 −39.020 −2.393 −1.082 1.00 21.07 C ATOM 4941 CZ PHE A 330 −38.829 −3.343 −2.046 1.00 22.00 C ATOM 4943 CE2 PHE A 330 −39.474 −4.568 −1.944 1.00 22.60 C ATOM 4945 CD2 PHE A 330 −40.309 −4.824 −.865 1.00 22.36 C ATOM 4947 C PHE A 330 −43.348 −3.863 −.281 1.00 22.99 C ATOM 4948 O PHE A 330 −43.350 −3.012 −1.182 1.00 22.98 O ATOM 4950 N LEU A 331 −43.789 −5.101 −.492 1.00 21.65 N ATOM 4951 CA LEU A 331 −44.306 −5.484 −1.816 1.00 20.74 C ATOM 4953 CB LEU A 331 −44.573 −6.990 −1.912 1.00 20.57 C ATOM 4956 CG LEU A 331 −44.959 −7.575 −3.277 1.00 19.82 C ATOM 4958 CD1 LEU A 331 −43.936 −7.246 −4.329 1.00 19.00 C ATOM 4962 CD2 LEU A 331 −45.128 −9.092 −3.165 1.00 19.11 C ATOM 4966 C LEU A 331 −45.568 −4.710 −2.159 1.00 19.98 C ATOM 4967 O LEU A 331 −45.753 −4.324 −3.300 1.00 20.15 O ATOM 4969 N ALA A 332 −46.431 −4.495 −1.172 1.00 19.09 N ATOM 4970 CA ALA A 332 −47.619 −3.675 −1.353 1.00 18.46 C ATOM 4972 CB ALA A 332 −48.406 −3.587 −.045 1.00 18.20 C ATOM 4976 C ALA A 332 −47.248 −2.279 −1.856 1.00 17.91 C ATOM 4977 O ALA A 332 −47.890 −1.745 −2.744 1.00 17.98 O ATOM 4979 N LEU A 333 −46.197 −1.706 −1.295 1.00 17.62 N ATOM 4980 CA LEU A 333 −45.753 −.353 −1.637 1.00 17.60 C ATOM 4982 CB LEU A 333 −44.725 .132 −.598 1.00 17.59 C ATOM 4985 CG LEU A 333 −44.122 1.533 −.761 1.00 17.16 C ATOM 4987 CD1 LEU A 333 −45.166 2.629 −.554 1.00 16.99 C ATOM 4991 CD2 LEU A 333 −42.979 1.704 .200 1.00 15.89 C ATOM 4995 C LEU A 333 −45.100 −.320 −3.005 1.00 17.70 C ATOM 4996 O LEU A 333 −45.321 .603 −3.795 1.00 17.86 O ATOM 4998 N TYR A 334 −44.248 −1.319 −3.234 1.00 17.63 N ATOM 4999 CA TYR A 334 −43.542 −1.531 −4.489 1.00 17.44 C ATOM 5001 CB TYR A 334 −42.893 −2.908 −4.444 1.00 17.50 C ATOM 5004 CG TYR A 334 −41.897 −3.169 −5.523 1.00 18.03 C ATOM 5005 CD1 TYR A 334 −40.698 −2.473 −5.569 1.00 18.83 C ATOM 5007 CE1 TYR A 334 −39.764 −2.725 −6.542 1.00 18.13 C ATOM 5009 CZ TYR A 334 −40.016 −3.678 −7.478 1.00 18.78 C ATOM 5010 OH TYR A 334 −39.096 −3.929 −8.439 1.00 21.71 O ATOM 5012 CE2 TYR A 334 −41.180 −4.391 −7.462 1.00 19.74 C ATOM 5014 CD2 TYR A 334 −42.118 −4.139 −6.472 1.00 19.59 C ATOM 5016 C TYR A 334 −44.500 −1.497 −5.649 1.00 17.43 C ATOM 5017 O TYR A 334 −44.264 −.803 −6.636 1.00 17.64 O ATOM 5019 N ASN A 335 −45.589 −2.253 −5.504 1.00 17.30 N ATOM 5020 CA ASN A 335 −46.574 −2.448 −6.553 1.00 17.23 C ATOM 5022 CB ASN A 335 −47.544 −3.551 −6.166 1.00 17.32 C ATOM 5025 CG ASN A 335 −46.952 −4.920 −6.332 1.00 18.16 C ATOM 5026 OD1 ASN A 335 −45.913 −5.090 −6.989 1.00 18.99 O ATOM 5027 ND2 ASN A 335 −47.616 −5.921 −5.749 1.00 18.49 N ATOM 5030 C ASN A 335 −47.365 −1.218 −6.812 1.00 17.12 C ATOM 5031 O ASN A 335 −47.613 −.852 −7.965 1.00 17.36 O ATOM 5033 N THR A 336 −47.789 −.602 −5.722 1.00 17.20 N ATOM 5034 CA THR A 336 −48.601 .593 −5.779 1.00 17.36 C ATOM 5036 CB THR A 336 −48.888 1.104 −4.381 1.00 17.20 C ATOM 5038 OG1 THR A 336 −49.611 .103 −3.657 1.00 16.26 O ATOM 5040 CG2 THR A 336 −49.688 2.384 −4.452 1.00 17.18 C ATOM 5044 C THR A 336 −47.893 1.691 −6.550 1.00 17.84 C ATOM 5045 O THR A 336 −48.511 2.388 −7.360 1.00 18.07 O ATOM 5047 N ILE A 337 −46.595 1.831 −6.298 1.00 18.14 N ATOM 5048 CA ILE A 337 −45.817 2.904 −6.895 1.00 18.50 C ATOM 5050 CB ILE A 337 −44.584 3.209 −6.066 1.00 18.31 C ATOM 5052 CG1 ILE A 337 −45.014 3.997 −4.837 1.00 18.58 C ATOM 5055 CD1 ILE A 337 −44.043 3.866 −3.735 1.00 20.66 C ATOM 5059 CG2 ILE A 337 −43.570 3.988 −6.867 1.00 16.98 C ATOM 5063 C ILE A 337 −45.447 2.548 −8.314 1.00 19.29 C ATOM 5064 O ILE A 337 −45.556 3.387 −9.214 1.00 19.17 O ATOM 5066 N ASN A 338 −45.033 1.299 −8.513 1.00 20.16 N ATOM 5067 CA ASN A 338 −44.861 .767 −9.864 1.00 20.93 C ATOM 5069 CB ASN A 338 −44.409 −.695 −9.830 1.00 21.07 C ATOM 5072 CG ASN A 338 −42.953 −.845 −9.439 1.00 21.61 C ATOM 5073 OD1 ASN A 338 −42.232 .143 −9.308 1.00 22.40 O ATOM 5074 ND2 ASN A 338 −42.509 −2.086 −9.260 1.00 21.92 N ATOM 5077 C ASN A 338 −46.123 .914 −10.719 1.00 21.44 C ATOM 5078 O ASN A 338 −46.022 1.202 −11.904 1.00 21.25 O ATOM 5080 N GLU A 339 −47.303 .747 −10.128 1.00 22.21 N ATOM 5081 CA GLU A 339 −48.532 1.000 −10.880 1.00 23.31 C ATOM 5083 CB GLU A 339 −49.768 .464 −10.164 1.00 24.13 C ATOM 5086 CG GLU A 339 −50.146 −.936 −10.660 1.00 28.69 C ATOM 5089 CD GLU A 339 −50.939 −1.740 −9.638 1.00 35.06 C ATOM 5090 OE1 GLU A 339 −51.899 −1.136 −9.067 1.00 39.51 O ATOM 5091 OE2 GLU A 339 −50.596 −2.952 −9.414 1.00 36.64 O ATOM 5092 C GLU A 339 −48.725 2.463 −11.269 1.00 22.71 C ATOM 5093 O GLU A 339 −49.215 2.743 −12.372 1.00 22.48 O ATOM 5095 N ILE A 340 −48.339 3.390 −10.390 1.00 22.19 N ATOM 5096 CA ILE A 340 −48.406 4.813 −10.734 1.00 21.64 C ATOM 5098 CB ILE A 340 −48.135 5.739 −9.538 1.00 21.33 C ATOM 5100 CG1 ILE A 340 −49.229 5.596 −8.482 1.00 21.29 C ATOM 5103 CD1 ILE A 340 −48.925 6.306 −7.150 1.00 20.00 C ATOM 5107 CG2 ILE A 340 −48.091 7.177 −9.982 1.00 20.28 C ATOM 5111 C ILE A 340 −47.414 5.128 −11.861 1.00 21.78 C ATOM 5112 O ILE A 340 −47.786 5.826 −12.818 1.00 22.13 O ATOM 5114 N ALA A 341 −46.179 4.609 −11.771 1.00 21.34 N ATOM 5115 CA ALA A 341 −45.147 4.892 −12.787 1.00 21.03 C ATOM 5117 CB ALA A 341 −43.837 4.268 −12.406 1.00 20.55 C ATOM 5121 C ALA A 341 −45.592 4.426 −14.183 1.00 21.32 C ATOM 5122 O ALA A 341 −45.228 5.036 −15.217 1.00 21.11 O ATOM 5124 N TYR A 342 −46.393 3.355 −14.196 1.00 21.45 N ATOM 5125 CA TYR A 342 −47.008 2.861 −15.414 1.00 21.41 C ATOM 5127 CB TYR A 342 −47.627 1.468 −15.208 1.00 21.31 C ATOM 5130 CG TYR A 342 −48.336 .957 −16.450 1.00 19.60 C ATOM 5131 CD1 TYR A 342 −47.613 .463 −17.521 1.00 16.69 C ATOM 5133 CE1 TYR A 342 −48.231 .032 −18.643 1.00 15.50 C ATOM 5135 CZ TYR A 342 −49.595 .085 −18.728 1.00 15.88 C ATOM 5136 OH TYR A 342 −50.196 −.352 −19.877 1.00 16.46 O ATOM 5138 CE2 TYR A 342 −50.352 .558 −17.681 1.00 16.50 C ATOM 5140 CD2 TYR A 342 −49.725 .997 −16.556 1.00 18.17 C ATOM 5142 C TYR A 342 −48.064 3.830 −15.899 1.00 22.08 C ATOM 5143 O TYR A 342 −48.094 4.169 −17.048 1.00 22.07 O ATOM 5145 N ASP A 343 −48.942 4.283 −15.032 1.00 23.41 N ATOM 5146 CA ASP A 343 −49.970 5.211 −15.481 1.00 24.66 C ATOM 5148 CB ASP A 343 −50.851 5.674 −14.318 1.00 25.10 C ATOM 5151 CG ASP A 343 −51.720 4.552 −13.732 1.00 26.06 C ATOM 5152 OD1 ASP A 343 −52.107 3.613 −14.477 1.00 26.39 O ATOM 5153 OD2 ASP A 343 −52.032 4.642 −12.516 1.00 27.29 O ATOM 5154 C ASP A 343 −49.316 6.420 −16.142 1.00 25.22 C ATOM 5155 O ASP A 343 −49.755 6.874 −17.192 1.00 25.47 O ATOM 5157 N ASN A 344 −48.260 6.936 −15.528 1.00 25.87 N ATOM 5158 CA ASN A 344 −47.508 8.042 −16.127 1.00 26.41 C ATOM 5160 CB ASN A 344 −46.498 8.605 −15.134 1.00 26.56 C ATOM 5163 CG ASN A 344 −47.152 9.407 −14.073 1.00 26.95 C ATOM 5164 OD1 ASN A 344 −47.495 10.568 −14.296 1.00 29.13 O ATOM 5165 ND2 ASN A 344 −47.367 8.799 −12.916 1.00 26.36 N ATOM 5168 C ASN A 344 −46.785 7.674 −17.416 1.00 26.53 C ATOM 5169 O ASN A 344 −46.658 8.508 −18.304 1.00 26.74 O ATOM 5171 N LEU A 345 −46.280 6.448 −17.510 1.00 26.56 N ATOM 5172 CA LEU A 345 −45.634 6.019 −18.739 1.00 26.37 C ATOM 5174 CB LEU A 345 −44.890 4.693 −18.550 1.00 26.32 C ATOM 5177 CG LEU A 345 −43.995 4.339 −19.750 1.00 25.96 C ATOM 5179 CD1 LEU A 345 −42.706 5.133 −19.665 1.00 25.07 C ATOM 5183 CD2 LEU A 345 −43.724 2.835 −19.874 1.00 24.75 C ATOM 5187 C LEU A 345 −46.679 5.908 −19.856 1.00 26.38 C ATOM 5188 O LEU A 345 −46.435 6.335 −20.966 1.00 26.52 O ATOM 5190 N LYS A 346 −47.839 5.340 −19.563 1.00 26.59 N ATOM 5191 CA LYS A 346 −48.880 5.176 −20.572 1.00 26.89 C ATOM 5193 CB LYS A 346 −50.065 4.367 −20.011 1.00 26.80 C ATOM 5196 CG LYS A 346 −51.073 3.931 −21.062 1.00 26.26 C ATOM 5199 CD LYS A 346 −52.210 3.080 −20.517 1.00 26.15 C ATOM 5202 CE LYS A 346 −53.227 3.849 −19.689 1.00 26.40 C ATOM 5205 NZ LYS A 346 −53.136 3.506 −18.223 1.00 27.67 N ATOM 5209 C LYS A 346 −49.372 6.537 −21.071 1.00 27.52 C ATOM 5210 O LYS A 346 −49.562 6.742 −22.272 1.00 27.57 O ATOM 5212 N ASP A 347 −49.567 7.472 −20.148 1.00 28.10 N ATOM 5213 CA ASP A 347 −50.309 8.689 −20.465 1.00 28.58 C ATOM 5215 CB ASP A 347 −51.305 9.017 −19.329 1.00 28.85 C ATOM 5218 CG ASP A 347 −52.426 7.950 −19.197 1.00 30.01 C ATOM 5219 OD1 ASP A 347 −52.827 7.349 −20.223 1.00 30.51 O ATOM 5220 OD2 ASP A 347 −52.910 7.704 −18.069 1.00 32.61 O ATOM 5221 C ASP A 347 −49.407 9.871 −20.804 1.00 28.22 C ATOM 5222 O ASP A 347 −49.778 10.710 −21.611 1.00 28.39 O ATOM 5224 N LYS A 348 −48.228 9.930 −20.206 1.00 28.03 N ATOM 5225 CA LYS A 348 −47.301 11.021 −20.467 1.00 28.01 C ATOM 5227 CB LYS A 348 −46.785 11.648 −19.164 1.00 28.39 C ATOM 5230 CG LYS A 348 −47.834 12.305 −18.257 1.00 30.18 C ATOM 5233 CD LYS A 348 −47.143 12.898 −17.003 1.00 32.40 C ATOM 5236 CE LYS A 348 −48.124 13.121 −15.874 1.00 33.59 C ATOM 5239 NZ LYS A 348 −49.319 13.878 −16.341 1.00 35.48 N ATOM 5243 C LYS A 348 −46.107 10.551 −21.260 1.00 27.25 C ATOM 5244 O LYS A 348 −45.241 11.345 −21.566 1.00 27.60 O ATOM 5246 N GLY A 349 −46.036 9.271 −21.583 1.00 26.47 N ATOM 5247 CA GLY A 349 −44.863 8.742 −22.261 1.00 26.01 C ATOM 5250 C GLY A 349 −43.559 9.109 −21.587 1.00 25.67 C ATOM 5251 O GLY A 349 −42.613 9.472 −22.250 1.00 25.85 O ATOM 5253 N GLU A 350 −43.498 9.032 −20.269 1.00 25.55 N ATOM 5254 CA GLU A 350 −42.272 9.374 −19.555 1.00 25.76 C ATOM 5256 CB GLU A 350 −42.332 10.814 −19.021 1.00 26.34 C ATOM 5259 CG GLU A 350 −42.179 11.928 −20.106 1.00 29.04 C ATOM 5262 CD GLU A 350 −40.745 12.101 −20.598 1.00 32.08 C ATOM 5263 OE1 GLU A 350 −39.853 12.170 −19.716 1.00 35.46 O ATOM 5264 OE2 GLU A 350 −40.516 12.174 −21.839 1.00 31.64 O ATOM 5265 C GLU A 350 −42.084 8.414 −18.400 1.00 24.87 C ATOM 5266 O GLU A 350 −43.067 8.046 −17.760 1.00 25.16 O ATOM 5268 N ASN A 351 −40.833 8.009 −18.145 1.00 23.71 N ATOM 5269 CA ASN A 351 −40.494 7.189 −16.980 1.00 22.88 C ATOM 5271 CB ASN A 351 −39.351 6.229 −17.287 1.00 22.88 C ATOM 5274 CG ASN A 351 −39.141 5.215 −16.184 1.00 22.98 C ATOM 5275 OD1 ASN A 351 −39.006 5.584 −15.035 1.00 22.68 O ATOM 5276 ND2 ASN A 351 −39.139 3.924 −16.529 1.00 24.38 N ATOM 5279 C ASN A 351 −40.126 8.058 −15.786 1.00 22.40 C ATOM 5280 O ASN A 351 −39.097 8.741 −15.785 1.00 22.66 O ATOM 5282 N ILE A 352 −40.965 8.021 −14.760 1.00 21.55 N ATOM 5283 CA ILE A 352 −40.770 8.860 −13.591 1.00 20.75 C ATOM 5285 CB ILE A 352 −42.002 9.788 −13.360 1.00 20.95 C ATOM 5287 CG1 ILE A 352 −43.263 8.970 −13.022 1.00 20.82 C ATOM 5290 CD1 ILE A 352 −44.237 9.698 −12.122 1.00 20.21 C ATOM 5294 CG2 ILE A 352 −42.266 10.669 −14.582 1.00 19.85 C ATOM 5298 C ILE A 352 −40.516 8.016 −12.339 1.00 20.37 C ATOM 5299 O ILE A 352 −40.574 8.513 −11.224 1.00 20.55 O ATOM 5301 N LEU A 353 −40.236 6.733 −12.519 1.00 19.98 N ATOM 5302 CA LEU A 353 −40.061 5.828 −11.387 1.00 19.42 C ATOM 5304 CB LEU A 353 −39.894 4.392 −11.870 1.00 19.27 C ATOM 5307 CG LEU A 353 −39.989 3.318 −10.799 1.00 19.01 C ATOM 5309 CD1 LEU A 353 −41.164 3.574 −9.867 1.00 18.35 C ATOM 5313 CD2 LEU A 353 −40.085 1.938 −11.468 1.00 18.74 C ATOM 5317 C LEU A 353 −38.890 6.240 −10.523 1.00 19.11 C ATOM 5318 O LEU A 353 −39.022 6.319 −9.314 1.00 18.96 O ATOM 5320 N PRO A 354 −37.746 6.549 −11.142 1.00 19.06 N ATOM 5321 CA PRO A 354 −36.631 7.069 −10.367 1.00 19.29 C ATOM 5323 CB PRO A 354 −35.749 7.717 −11.438 1.00 19.25 C ATOM 5326 CG PRO A 354 −35.997 6.942 −12.638 1.00 19.08 C ATOM 5329 CD PRO A 354 −37.409 6.472 −12.572 1.00 19.00 C ATOM 5332 C PRO A 354 −37.024 8.122 −9.328 1.00 19.33 C ATOM 5333 O PRO A 354 −36.534 8.057 −8.193 1.00 19.73 O ATOM 5334 N TYR A 355 −37.891 9.063 −9.721 1.00 18.83 N ATOM 5335 CA TYR A 355 −38.206 10.221 −8.898 1.00 18.79 C ATOM 5337 CB TYR A 355 −38.836 11.359 −9.707 1.00 19.10 C ATOM 5340 CG TYR A 355 −38.142 11.708 −11.009 1.00 20.15 C ATOM 5341 CD1 TYR A 355 −36.940 12.403 −11.027 1.00 20.78 C ATOM 5343 CE1 TYR A 355 −36.321 12.719 −12.232 1.00 22.19 C ATOM 5345 CZ TYR A 355 −36.918 12.347 −13.438 1.00 22.19 C ATOM 5346 OH TYR A 355 −36.341 12.660 −14.657 1.00 23.29 O ATOM 5348 CE2 TYR A 355 −38.113 11.677 −13.430 1.00 21.62 C ATOM 5350 CD2 TYR A 355 −38.720 11.371 −12.227 1.00 21.05 C ATOM 5352 C TYR A 355 −39.155 9.864 −7.777 1.00 18.43 C ATOM 5353 O TYR A 355 −39.081 10.460 −6.709 1.00 18.61 O ATOM 5355 N LEU A 356 −40.058 8.917 −8.023 1.00 17.92 N ATOM 5356 CA LEU A 356 −40.993 8.467 −6.994 1.00 17.38 C ATOM 5358 CB LEU A 356 −42.136 7.658 −7.597 1.00 17.17 C ATOM 5361 CG LEU A 356 −42.956 8.366 −8.682 1.00 17.56 C ATOM 5363 CD1 LEU A 356 −43.933 7.419 −9.371 1.00 17.47 C ATOM 5367 CD2 LEU A 356 −43.698 9.548 −8.112 1.00 18.08 C ATOM 5371 C LEU A 356 −40.241 7.623 −5.978 1.00 17.10 C ATOM 5372 O LEU A 356 −40.332 7.859 −4.783 1.00 17.62 O ATOM 5374 N THR A 357 −39.464 6.656 −6.442 1.00 16.64 N ATOM 5375 CA THR A 357 −38.775 5.769 −5.513 1.00 16.18 C ATOM 5377 CB THR A 357 −38.104 4.554 −6.213 1.00 16.04 C ATOM 5379 OG1 THR A 357 −37.092 4.996 −7.123 1.00 15.93 O ATOM 5381 CG2 THR A 357 −39.142 3.732 −6.962 1.00 14.99 C ATOM 5385 C THR A 357 −37.764 6.544 −4.686 1.00 16.16 C ATOM 5386 O THR A 357 −37.599 6.278 −3.506 1.00 16.07 O ATOM 5388 N LYS A 358 −37.107 7.524 −5.291 1.00 16.20 N ATOM 5389 CA LYS A 358 −36.186 8.365 −4.543 1.00 16.46 C ATOM 5391 CB LYS A 358 −35.518 9.386 −5.453 1.00 16.80 C ATOM 5394 CG LYS A 358 −34.612 10.388 −4.741 1.00 18.30 C ATOM 5397 CD LYS A 358 −33.352 9.738 −4.168 1.00 20.21 C ATOM 5400 CE LYS A 358 −32.335 10.811 −3.768 1.00 21.96 C ATOM 5403 NZ LYS A 358 −31.163 10.275 −3.019 1.00 22.95 N ATOM 5407 C LYS A 358 −36.936 9.083 −3.440 1.00 16.26 C ATOM 5408 O LYS A 358 −36.448 9.161 −2.320 1.00 16.15 O ATOM 5410 N ALA A 359 −38.126 9.593 −3.763 1.00 16.11 N ATOM 5411 CA ALA A 359 −38.937 10.332 −2.798 1.00 16.10 C ATOM 5413 CB ALA A 359 −40.221 10.768 −3.406 1.00 15.71 C ATOM 5417 C ALA A 359 −39.215 9.476 −1.588 1.00 16.52 C ATOM 5418 O ALA A 359 −39.247 9.970 −.442 1.00 16.82 O ATOM 5420 N TRP A 360 −39.398 8.187 −1.843 1.00 16.79 N ATOM 5421 CA TRP A 360 −39.704 7.247 −.780 1.00 17.25 C ATOM 5423 CB TRP A 360 −40.390 6.006 −1.352 1.00 17.41 C ATOM 5426 CG TRP A 360 −41.852 6.129 −1.318 1.00 17.06 C ATOM 5427 CD1 TRP A 360 −42.664 6.451 −2.346 1.00 17.94 C ATOM 5429 NE1 TRP A 360 −43.967 6.489 −1.926 1.00 18.03 N ATOM 5431 CE2 TRP A 360 −44.002 6.193 −.592 1.00 17.72 C ATOM 5432 CD2 TRP A 360 −42.684 5.965 −.179 1.00 16.60 C ATOM 5433 CE3 TRP A 360 −42.441 5.654 1.155 1.00 16.65 C ATOM 5435 CZ3 TRP A 360 −43.508 5.573 2.022 1.00 16.91 C ATOM 5437 CH2 TRP A 360 −44.811 5.807 1.586 1.00 17.82 C ATOM 5439 CZ2 TRP A 360 −45.080 6.114 .282 1.00 18.49 C ATOM 5441 C TRP A 360 −38.490 6.865 .073 1.00 17.52 C ATOM 5442 O TRP A 360 −38.603 6.767 1.297 1.00 17.38 O ATOM 5444 N ALA A 361 −37.344 6.651 −.568 1.00 17.82 N ATOM 5445 CA ALA A 361 −36.122 6.336 .157 1.00 18.11 C ATOM 5447 CB ALA A 361 −34.982 6.050 −.805 1.00 17.92 C ATOM 5451 C ALA A 361 −35.781 7.507 1.063 1.00 18.52 C ATOM 5452 O ALA A 361 −35.434 7.327 2.229 1.00 18.48 O ATOM 5454 N ASP A 362 −35.911 8.711 .521 1.00 19.16 N ATOM 5455 CA ASP A 362 −35.627 9.925 1.276 1.00 19.90 C ATOM 5457 CB ASP A 362 −35.797 11.167 .387 1.00 20.39 C ATOM 5460 CG ASP A 362 −34.596 11.424 −.530 1.00 21.84 C ATOM 5461 OD1 ASP A 362 −33.630 10.625 −.561 1.00 22.88 O ATOM 5462 OD2 ASP A 362 −34.630 12.453 −1.231 1.00 24.83 O ATOM 5463 C ASP A 362 −36.532 10.039 2.510 1.00 19.91 C ATOM 5464 O ASP A 362 −36.074 10.427 3.591 1.00 19.76 O ATOM 5466 N LEU A 363 −37.813 9.707 2.346 1.00 19.95 N ATOM 5467 CA LEU A 363 −38.747 9.688 3.478 1.00 19.85 C ATOM 5469 CB LEU A 363 −40.175 9.415 3.006 1.00 19.70 C ATOM 5472 CG LEU A 363 −41.219 9.293 4.123 1.00 18.58 C ATOM 5474 CD1 LEU A 363 −41.189 10.551 4.965 1.00 18.37 C ATOM 5478 CD2 LEU A 363 −42.597 9.073 3.551 1.00 16.43 C ATOM 5482 C LEU A 363 −38.368 8.613 4.488 1.00 20.24 C ATOM 5483 O LEU A 363 −38.314 8.875 5.691 1.00 20.52 O ATOM 5485 N CYS A 364 −38.129 7.397 3.997 1.00 20.29 N ATOM 5486 CA CYS A 364 −37.741 6.308 4.874 1.00 20.39 C ATOM 5488 CB CYS A 364 −37.595 4.985 4.111 1.00 20.37 C ATOM 5491 SG CYS A 364 −39.208 4.201 3.666 1.00 20.69 S ATOM 5493 C CYS A 364 −36.467 6.683 5.646 1.00 20.59 C ATOM 5494 O CYS A 364 −36.386 6.445 6.863 1.00 20.82 O ATOM 5496 N ASN A 365 −35.495 7.314 4.980 1.00 20.35 N ATOM 5497 CA ASN A 365 −34.282 7.716 5.697 1.00 20.14 C ATOM 5499 CB ASN A 365 −33.188 8.203 4.754 1.00 20.18 C ATOM 5502 CG ASN A 365 −32.359 7.064 4.184 1.00 20.55 C ATOM 5503 OD1 ASN A 365 −31.706 6.316 4.925 1.00 20.40 O ATOM 5504 ND2 ASN A 365 −32.365 6.938 2.854 1.00 21.25 N ATOM 5507 C ASN A 365 −34.590 8.746 6.779 1.00 19.92 C ATOM 5508 O ASN A 365 −33.997 8.685 7.857 1.00 19.94 O ATOM 5510 N ALA A 366 −35.531 9.658 6.507 1.00 19.58 N ATOM 5511 CA ALA A 366 −36.036 10.578 7.537 1.00 19.39 C ATOM 5513 CB ALA A 366 −37.083 11.507 6.971 1.00 18.79 C ATOM 5517 C ALA A 366 −36.597 9.784 8.730 1.00 19.75 C ATOM 5518 O ALA A 366 −36.215 10.049 9.891 1.00 19.53 O ATOM 5520 N PHE A 367 −37.460 8.797 8.447 1.00 19.69 N ATOM 5521 CA PHE A 367 −37.985 7.925 9.502 1.00 20.11 C ATOM 5523 CB PHE A 367 −38.952 6.857 8.967 1.00 20.47 C ATOM 5526 CG PHE A 367 −40.293 7.370 8.494 1.00 21.35 C ATOM 5527 CD1 PHE A 367 −40.985 8.347 9.180 1.00 21.54 C ATOM 5529 CE1 PHE A 367 −42.224 8.775 8.732 1.00 21.47 C ATOM 5531 CZ PHE A 367 −42.798 8.213 7.612 1.00 21.87 C ATOM 5533 CE2 PHE A 367 −42.135 7.230 6.924 1.00 22.60 C ATOM 5535 CD2 PHE A 367 −40.894 6.798 7.373 1.00 22.90 C ATOM 5537 C PHE A 367 −36.871 7.179 10.252 1.00 20.12 C ATOM 5538 O PHE A 367 −36.940 7.009 11.476 1.00 19.88 O ATOM 5540 N LEU A 368 −35.868 6.696 9.516 1.00 20.30 N ATOM 5541 CA LEU A 368 −34.775 5.931 10.133 1.00 20.19 C ATOM 5543 CB LEU A 368 −33.783 5.413 9.085 1.00 20.08 C ATOM 5546 CG LEU A 368 −32.743 4.363 9.514 1.00 19.30 C ATOM 5548 CD1 LEU A 368 −33.384 3.227 10.260 1.00 18.66 C ATOM 5552 CD2 LEU A 368 −31.968 3.807 8.319 1.00 18.16 C ATOM 5556 C LEU A 368 −34.063 6.812 11.128 1.00 20.41 C ATOM 5557 O LEU A 368 −33.842 6.407 12.257 1.00 20.01 O ATOM 5559 N GLN A 369 −33.751 8.036 10.711 1.00 20.89 N ATOM 5560 CA GLN A 369 −33.037 8.970 11.564 1.00 21.49 C ATOM 5562 CB GLN A 369 −32.782 10.280 10.832 1.00 21.58 C ATOM 5565 CG GLN A 369 −32.071 11.359 11.677 1.00 21.20 C ATOM 5568 CD GLN A 369 −30.639 11.006 11.976 1.00 20.04 C ATOM 5569 OE1 GLN A 369 −30.282 10.650 13.108 1.00 19.10 O ATOM 5570 NE2 GLN A 369 −29.803 11.095 10.956 1.00 18.75 N ATOM 5573 C GLN A 369 −33.763 9.265 12.870 1.00 22.21 C ATOM 5574 O GLN A 369 −33.122 9.343 13.909 1.00 22.41 O ATOM 5576 N GLU A 370 −35.080 9.455 12.822 1.00 23.05 N ATOM 5577 CA GLU A 370 −35.856 9.718 14.046 1.00 23.71 C ATOM 5579 CB GLU A 370 −37.329 10.041 13.726 1.00 24.04 C ATOM 5582 CG GLU A 370 −37.484 11.293 12.862 1.00 26.84 C ATOM 5585 CD GLU A 370 −38.897 11.910 12.834 1.00 30.36 C ATOM 5586 OE1 GLU A 370 −39.886 11.161 12.586 1.00 31.90 O ATOM 5587 OE2 GLU A 370 −38.992 13.164 13.014 1.00 31.62 O ATOM 5588 C GLU A 370 −35.755 8.523 14.994 1.00 23.60 C ATOM 5589 O GLU A 370 −35.534 8.689 16.199 1.00 23.33 O ATOM 5591 N ALA A 371 −35.904 7.322 14.435 1.00 23.72 N ATOM 5592 CA ALA A 371 −35.771 6.091 15.201 1.00 23.91 C ATOM 5594 CB ALA A 371 −35.991 4.868 14.312 1.00 23.76 C ATOM 5598 C ALA A 371 −34.392 6.051 15.840 1.00 24.20 C ATOM 5599 O ALA A 371 −34.277 5.804 17.035 1.00 24.54 O ATOM 5601 N LYS A 372 −33.355 6.333 15.049 1.00 24.38 N ATOM 5602 CA LYS A 372 −31.979 6.273 15.530 1.00 24.39 C ATOM 5604 CB LYS A 372 −30.970 6.466 14.393 1.00 24.43 C ATOM 5607 CG LYS A 372 −30.623 5.164 13.645 1.00 25.20 C ATOM 5610 CD LYS A 372 −29.188 5.149 13.069 1.00 26.09 C ATOM 5613 CE LYS A 372 −29.114 5.437 11.557 1.00 27.01 C ATOM 5616 NZ LYS A 372 −29.002 4.200 10.709 1.00 26.82 N ATOM 5620 C LYS A 372 −31.717 7.268 16.645 1.00 24.59 C ATOM 5621 O LYS A 372 −31.096 6.908 17.627 1.00 25.13 O ATOM 5623 N TRP A 373 −32.181 8.507 16.520 1.00 24.78 N ATOM 5624 CA TRP A 373 −32.006 9.473 17.610 1.00 24.90 C ATOM 5626 CB TRP A 373 −32.565 10.863 17.266 1.00 24.75 C ATOM 5629 CG TRP A 373 −31.701 11.677 16.338 1.00 23.59 C ATOM 5630 CD1 TRP A 373 −30.344 11.663 16.259 1.00 22.38 C ATOM 5632 NE1 TRP A 373 −29.915 12.539 15.298 1.00 21.59 N ATOM 5634 CE2 TRP A 373 −30.999 13.162 14.744 1.00 21.69 C ATOM 5635 CD2 TRP A 373 −32.147 12.644 15.376 1.00 22.41 C ATOM 5636 CE3 TRP A 373 −33.409 13.110 14.976 1.00 21.98 C ATOM 5638 CZ3 TRP A 373 −33.480 14.072 13.979 1.00 22.08 C ATOM 5640 CH2 TRP A 373 −32.313 14.567 13.366 1.00 22.31 C ATOM 5642 CZ2 TRP A 373 −31.067 14.124 13.736 1.00 21.87 C ATOM 5644 C TRP A 373 −32.678 8.970 18.881 1.00 25.53 C ATOM 5645 O TRP A 373 −32.101 9.072 19.972 1.00 25.99 O ATOM 5647 N LEU A 374 −33.881 8.420 18.739 1.00 25.84 N ATOM 5648 CA LEU A 374 −34.667 7.980 19.893 1.00 26.29 C ATOM 5650 CB LEU A 374 −36.070 7.562 19.443 1.00 26.32 C ATOM 5653 CG LEU A 374 −37.227 7.646 20.444 1.00 26.39 C ATOM 5655 CD1 LEU A 374 −38.456 8.286 19.761 1.00 26.95 C ATOM 5659 CD2 LEU A 374 −37.583 6.281 21.050 1.00 26.24 C ATOM 5663 C LEU A 374 −33.982 6.824 20.623 1.00 26.77 C ATOM 5664 O LEU A 374 −33.995 6.758 21.860 1.00 26.95 O ATOM 5666 N TYR A 375 −33.383 5.919 19.854 1.00 27.23 N ATOM 5667 CA TYR A 375 −32.706 4.761 20.425 1.00 27.74 C ATOM 5669 CB TYR A 375 −32.195 3.814 19.328 1.00 27.78 C ATOM 5672 CG TYR A 375 −31.526 2.556 19.848 1.00 28.74 C ATOM 5673 CD1 TYR A 375 −32.264 1.394 20.090 1.00 29.61 C ATOM 5675 CE1 TYR A 375 −31.652 .232 20.573 1.00 29.89 C ATOM 5677 CZ TYR A 375 −30.287 .226 20.817 1.00 30.15 C ATOM 5678 OH TYR A 375 −29.676 −.917 21.286 1.00 30.57 O ATOM 5680 CE2 TYR A 375 −29.530 1.367 20.579 1.00 30.05 C ATOM 5682 CD2 TYR A 375 −30.152 2.522 20.096 1.00 29.74 C ATOM 5684 C TYR A 375 −31.553 5.248 21.275 1.00 27.97 C ATOM 5685 O TYR A 375 −31.404 4.837 22.422 1.00 28.00 O ATOM 5687 N ASN A 376 −30.763 6.158 20.719 1.00 28.32 N ATOM 5688 CA ASN A 376 −29.531 6.590 21.368 1.00 28.71 C ATOM 5690 CB ASN A 376 −28.569 7.161 20.329 1.00 28.60 C ATOM 5693 CG ASN A 376 −28.215 6.159 19.255 1.00 28.32 C ATOM 5694 OD1 ASN A 376 −27.961 4.977 19.527 1.00 25.72 O ATOM 5695 ND2 ASN A 376 −28.195 6.631 18.015 1.00 29.29 N ATOM 5698 C ASN A 376 −29.728 7.617 22.484 1.00 29.05 C ATOM 5699 O ASN A 376 −28.752 8.021 23.136 1.00 29.03 O ATOM 5701 N LYS A 377 −30.977 8.021 22.716 1.00 29.16 N ATOM 5702 CA LYS A 377 −31.254 9.178 23.549 1.00 29.27 C ATOM 5704 CB LYS A 377 −31.051 8.879 25.050 1.00 29.52 C ATOM 5707 CG LYS A 377 −32.202 8.112 25.723 1.00 30.36 C ATOM 5710 CD LYS A 377 −32.202 6.638 25.340 1.00 31.54 C ATOM 5713 CE LYS A 377 −33.322 5.862 26.031 1.00 32.30 C ATOM 5716 NZ LYS A 377 −33.559 4.509 25.411 1.00 32.13 N ATOM 5720 C LYS A 377 −30.337 10.299 23.080 1.00 28.92 C ATOM 5721 O LYS A 377 −29.590 10.867 23.875 1.00 28.94 O ATOM 5723 N SER A 378 −30.377 10.575 21.776 1.00 28.52 N ATOM 5724 CA SER A 378 −29.652 11.700 21.201 1.00 28.30 C ATOM 5726 CB SER A 378 −29.623 11.620 19.678 1.00 28.33 C ATOM 5729 OG SER A 378 −28.919 10.482 19.237 1.00 29.36 O ATOM 5731 C SER A 378 −30.355 12.977 21.594 1.00 27.97 C ATOM 5732 O SER A 378 −31.483 12.947 22.108 1.00 27.91 O ATOM 5734 N THR A 379 −29.684 14.098 21.344 1.00 27.60 N ATOM 5735 CA THR A 379 −30.257 15.422 21.581 1.00 27.24 C ATOM 5737 CB THR A 379 −29.929 15.950 23.002 1.00 27.23 C ATOM 5739 OG1 THR A 379 −28.512 16.102 23.158 1.00 26.85 O ATOM 5741 CG2 THR A 379 −30.467 15.007 24.067 1.00 27.48 C ATOM 5745 C THR A 379 −29.738 16.414 20.548 1.00 26.83 C ATOM 5746 O THR A 379 −28.834 17.190 20.844 1.00 26.69 O ATOM 5748 N PRO A 380 −30.305 16.390 19.331 1.00 26.56 N ATOM 5749 CA PRO A 380 −29.884 17.315 18.278 1.00 26.52 C ATOM 5751 CB PRO A 380 −30.380 16.648 16.992 1.00 26.46 C ATOM 5754 CG PRO A 380 −31.281 15.533 17.408 1.00 26.41 C ATOM 5757 CD PRO A 380 −31.395 15.508 18.887 1.00 26.53 C ATOM 5760 C PRO A 380 −30.469 18.728 18.386 1.00 26.55 C ATOM 5761 O PRO A 380 −31.472 18.966 19.063 1.00 26.69 O ATOM 5762 N THR A 381 −29.840 19.661 17.692 1.00 26.51 N ATOM 5763 CA THR A 381 −30.299 21.034 17.699 1.00 26.51 C ATOM 5765 CB THR A 381 −29.261 21.955 17.033 1.00 26.99 C ATOM 5767 OG1 THR A 381 −28.919 21.431 15.732 1.00 27.65 O ATOM 5769 CG2 THR A 381 −28.003 22.082 17.930 1.00 26.41 C ATOM 5773 C THR A 381 −31.635 21.167 16.970 1.00 26.06 C ATOM 5774 O THR A 381 −31.972 20.347 16.112 1.00 26.03 O ATOM 5776 N PHE A 382 −32.386 22.218 17.294 1.00 25.52 N ATOM 5777 CA PHE A 382 −33.681 22.436 16.654 1.00 24.83 C ATOM 5779 CB PHE A 382 −34.284 23.793 17.011 1.00 24.53 C ATOM 5782 CG PHE A 382 −35.495 24.113 16.211 1.00 23.77 C ATOM 5783 CD1 PHE A 382 −36.745 23.715 16.637 1.00 24.50 C ATOM 5785 CE1 PHE A 382 −37.873 23.977 15.878 1.00 24.49 C ATOM 5787 CZ PHE A 382 −37.744 24.630 14.673 1.00 24.41 C ATOM 5789 CE2 PHE A 382 −36.490 25.014 14.235 1.00 23.88 C ATOM 5791 CD2 PHE A 382 −35.381 24.752 14.999 1.00 23.29 C ATOM 5793 C PHE A 382 −33.542 22.342 15.150 1.00 24.49 C ATOM 5794 O PHE A 382 −34.361 21.731 14.485 1.00 24.32 O ATOM 5796 N ASP A 383 −32.498 22.969 14.627 1.00 24.42 N ATOM 5797 CA ASP A 383 −32.257 23.005 13.190 1.00 24.19 C ATOM 5799 CB ASP A 383 −31.101 23.966 12.867 1.00 24.21 C ATOM 5802 CG ASP A 383 −31.473 25.423 13.050 1.00 23.72 C ATOM 5803 OD1 ASP A 383 −32.634 25.794 12.837 1.00 25.60 O ATOM 5804 OD2 ASP A 383 −30.594 26.220 13.383 1.00 24.03 O ATOM 5805 C ASP A 383 −31.982 21.612 12.599 1.00 24.06 C ATOM 5806 O ASP A 383 −32.393 21.342 11.473 1.00 24.00 O ATOM 5808 N ASP A 384 −31.298 20.739 13.336 1.00 23.78 N ATOM 5809 CA ASP A 384 −31.078 19.379 12.848 1.00 24.11 C ATOM 5811 CB ASP A 384 −29.981 18.651 13.632 1.00 24.54 C ATOM 5814 CG ASP A 384 −28.573 19.009 13.159 1.00 26.32 C ATOM 5815 OD1 ASP A 384 −28.441 19.852 12.232 1.00 28.55 O ATOM 5816 OD2 ASP A 384 −27.599 18.451 13.728 1.00 27.18 O ATOM 5817 C ASP A 384 −32.351 18.550 12.905 1.00 23.83 C ATOM 5818 O ASP A 384 −32.670 17.825 11.955 1.00 24.24 O ATOM 5820 N TYR A 385 −33.070 18.637 14.017 1.00 23.31 N ATOM 5821 CA TYR A 385 −34.294 17.861 14.179 1.00 22.89 C ATOM 5823 CB TYR A 385 −34.833 17.979 15.608 1.00 22.86 C ATOM 5826 CG TYR A 385 −36.144 17.245 15.807 1.00 22.65 C ATOM 5827 CD1 TYR A 385 −36.163 15.868 16.030 1.00 22.36 C ATOM 5829 CE1 TYR A 385 −37.351 15.189 16.206 1.00 22.77 C ATOM 5831 CZ TYR A 385 −38.545 15.887 16.146 1.00 23.54 C ATOM 5832 OH TYR A 385 −39.733 15.212 16.309 1.00 24.38 O ATOM 5834 CE2 TYR A 385 −38.554 17.258 15.913 1.00 22.76 C ATOM 5836 CD2 TYR A 385 −37.360 17.923 15.744 1.00 22.12 C ATOM 5838 C TYR A 385 −35.375 18.299 13.190 1.00 22.55 C ATOM 5839 O TYR A 385 −36.050 17.467 12.584 1.00 22.85 O ATOM 5841 N PHE A 386 −35.537 19.609 13.042 1.00 22.08 N ATOM 5842 CA PHE A 386 −36.626 20.155 12.248 1.00 21.62 C ATOM 5844 CB PHE A 386 −36.857 21.628 12.568 1.00 21.73 C ATOM 5847 CG PHE A 386 −38.033 22.209 11.851 1.00 21.54 C ATOM 5848 CD1 PHE A 386 −39.311 21.933 12.273 1.00 21.29 C ATOM 5850 CE1 PHE A 386 −40.380 22.444 11.623 1.00 22.11 C ATOM 5852 CZ PHE A 386 −40.193 23.240 10.517 1.00 23.28 C ATOM 5854 CE2 PHE A 386 −38.920 23.502 10.069 1.00 23.10 C ATOM 5856 CD2 PHE A 386 −37.853 22.989 10.737 1.00 22.15 C ATOM 5858 C PHE A 386 −36.369 19.987 10.769 1.00 21.09 C ATOM 5859 O PHE A 386 −37.278 19.700 10.006 1.00 20.91 O ATOM 5861 N GLY A 387 −35.127 20.177 10.362 1.00 20.68 N ATOM 5862 CA GLY A 387 −34.747 19.917 8.985 1.00 20.43 C ATOM 5865 C GLY A 387 −35.151 18.521 8.544 1.00 19.95 C ATOM 5866 O GLY A 387 −35.553 18.327 7.398 1.00 20.24 O ATOM 5868 N ASN A 388 −35.032 17.554 9.451 1.00 19.12 N ATOM 5869 CA ASN A 388 −35.451 16.182 9.202 1.00 18.73 C ATOM 5871 CB ASN A 388 −34.744 15.272 10.205 1.00 18.90 C ATOM 5874 CG ASN A 388 −34.863 13.795 9.871 1.00 18.35 C ATOM 5875 OD1 ASN A 388 −34.163 13.284 8.993 1.00 17.24 O ATOM 5876 ND2 ASN A 388 −35.714 13.092 10.614 1.00 17.01 N ATOM 5879 C ASN A 388 −36.968 16.033 9.350 1.00 18.65 C ATOM 5880 O ASN A 388 −37.624 15.370 8.551 1.00 18.82 O ATOM 5882 N ALA A 389 −37.527 16.670 10.371 1.00 18.38 N ATOM 5883 CA ALA A 389 −38.926 16.477 10.728 1.00 18.02 C ATOM 5885 CB ALA A 389 −39.203 17.107 12.084 1.00 17.83 C ATOM 5889 C ALA A 389 −39.949 16.966 9.700 1.00 17.90 C ATOM 5890 O ALA A 389 −41.095 16.544 9.760 1.00 17.74 O ATOM 5892 N TRP A 390 −39.585 17.860 8.783 1.00 18.11 N ATOM 5893 CA TRP A 390 −40.543 18.254 7.731 1.00 18.46 C ATOM 5895 CB TRP A 390 −40.459 19.737 7.329 1.00 18.59 C ATOM 5898 CG TRP A 390 −39.143 20.224 6.821 1.00 19.26 C ATOM 5899 CD1 TRP A 390 −38.224 20.947 7.519 1.00 20.64 C ATOM 5901 NE1 TRP A 390 −37.138 21.224 6.729 1.00 20.62 N ATOM 5903 CE2 TRP A 390 −37.352 20.694 5.485 1.00 19.57 C ATOM 5904 CD2 TRP A 390 −38.607 20.066 5.504 1.00 19.15 C ATOM 5905 CE3 TRP A 390 −39.060 19.448 4.344 1.00 20.13 C ATOM 5907 CZ3 TRP A 390 −38.254 19.477 3.224 1.00 20.27 C ATOM 5909 CH2 TRP A 390 −37.017 20.110 3.239 1.00 19.38 C ATOM 5911 CZ2 TRP A 390 −36.549 20.724 4.356 1.00 19.49 C ATOM 5913 C TRP A 390 −40.407 17.343 6.527 1.00 18.73 C ATOM 5914 O TRP A 390 −41.369 17.143 5.788 1.00 18.32 O ATOM 5916 N LYS A 391 −39.200 16.806 6.336 1.00 19.30 N ATOM 5917 CA LYS A 391 −38.969 15.692 5.404 1.00 19.70 C ATOM 5919 CB LYS A 391 −37.459 15.392 5.244 1.00 19.92 C ATOM 5922 CG LYS A 391 −36.812 15.953 3.935 1.00 22.08 C ATOM 5925 CD LYS A 391 −35.257 16.217 4.040 1.00 23.92 C ATOM 5928 CE LYS A 391 −34.918 17.698 4.426 1.00 24.43 C ATOM 5931 NZ LYS A 391 −33.699 17.901 5.307 1.00 23.23 N ATOM 5935 C LYS A 391 −39.731 14.441 5.861 1.00 19.46 C ATOM 5936 O LYS A 391 −40.284 13.709 5.032 1.00 20.07 O ATOM 5938 N SER A 392 −39.793 14.202 7.170 1.00 18.95 N ATOM 5939 CA SER A 392 −40.455 12.998 7.666 1.00 18.63 C ATOM 5941 CB SER A 392 −39.850 12.508 9.000 1.00 18.75 C ATOM 5944 OG SER A 392 −40.314 13.230 10.126 1.00 18.94 O ATOM 5946 C SER A 392 −41.964 13.152 7.771 1.00 18.20 C ATOM 5947 O SER A 392 −42.654 12.182 8.031 1.00 18.12 O ATOM 5949 N SER A 393 −42.477 14.360 7.567 1.00 18.07 N ATOM 5950 CA SER A 393 −43.929 14.591 7.556 1.00 18.02 C ATOM 5952 CB SER A 393 −44.229 16.078 7.504 1.00 18.08 C ATOM 5955 OG SER A 393 −43.995 16.558 6.192 1.00 18.01 O ATOM 5957 C SER A 393 −44.594 13.971 6.340 1.00 17.87 C ATOM 5958 O SER A 393 −45.778 13.661 6.372 1.00 18.03 O ATOM 5960 N SER A 394 −43.823 13.841 5.264 1.00 17.69 N ATOM 5961 CA SER A 394 −44.284 13.306 3.989 1.00 17.59 C ATOM 5963 CB SER A 394 −45.329 12.180 4.149 1.00 17.61 C ATOM 5966 OG SER A 394 −46.648 12.681 4.294 1.00 17.18 O ATOM 5968 C SER A 394 −44.828 14.415 3.115 1.00 17.42 C ATOM 5969 O SER A 394 −45.345 14.146 2.024 1.00 17.31 O ATOM 5971 N GLY A 395 −44.711 15.654 3.592 1.00 17.23 N ATOM 5972 CA GLY A 395 −45.088 16.827 2.807 1.00 17.26 C ATOM 5975 C GLY A 395 −44.478 16.749 1.415 1.00 17.29 C ATOM 5976 O GLY A 395 −45.203 16.653 .413 1.00 18.06 O ATOM 5978 N PRO A 396 −43.145 16.754 1.331 1.00 16.72 N ATOM 5979 CA PRO A 396 −42.582 16.610 .006 1.00 16.40 C ATOM 5981 CB PRO A 396 −41.080 16.549 .259 1.00 16.62 C ATOM 5984 CG PRO A 396 −40.903 16.749 1.775 1.00 17.11 C ATOM 5987 CD PRO A 396 −42.157 17.252 2.296 1.00 16.87 C ATOM 5990 C PRO A 396 −43.053 15.374 −.748 1.00 15.89 C ATOM 5991 O PRO A 396 −43.501 15.498 −1.894 1.00 15.90 O ATOM 5992 N LEU A 397 −42.973 14.197 −.135 1.00 15.27 N ATOM 5993 CA LEU A 397 −43.287 12.976 −.886 1.00 14.57 C ATOM 5995 CB LEU A 397 −43.332 11.733 −.008 1.00 14.36 C ATOM 5998 CG LEU A 397 −43.541 10.431 −.781 1.00 14.02 C ATOM 6000 CD1 LEU A 397 −42.690 9.348 −.206 1.00 15.04 C ATOM 6004 CD2 LEU A 397 −44.985 9.976 −.805 1.00 13.75 C ATOM 6008 C LEU A 397 −44.618 13.182 −1.542 1.00 14.39 C ATOM 6009 O LEU A 397 −44.736 12.999 −2.745 1.00 14.57 O ATOM 6011 N GLN A 398 −45.604 13.607 −.751 1.00 14.08 N ATOM 6012 CA GLN A 398 −46.962 13.828 −1.245 1.00 13.91 C ATOM 6014 CB GLN A 398 −47.860 14.363 −.136 1.00 13.99 C ATOM 6017 CG GLN A 398 −48.274 13.321 .909 1.00 14.01 C ATOM 6020 CD GLN A 398 −49.189 13.902 1.983 1.00 13.41 C ATOM 6021 OE1 GLN A 398 −49.941 14.847 1.740 1.00 14.65 O ATOM 6022 NE2 GLN A 398 −49.122 13.344 3.168 1.00 12.17 N ATOM 6025 C GLN A 398 −47.015 14.800 −2.403 1.00 13.84 C ATOM 6026 O GLN A 398 −47.677 14.547 −3.396 1.00 13.46 O ATOM 6028 N LEU A 399 −46.319 15.922 −2.272 1.00 14.11 N ATOM 6029 CA LEU A 399 −46.359 16.942 −3.315 1.00 14.37 C ATOM 6031 CB LEU A 399 −45.900 18.282 −2.756 1.00 14.26 C ATOM 6034 CG LEU A 399 −46.882 18.830 −1.704 1.00 14.44 C ATOM 6036 CD1 LEU A 399 −46.250 19.960 −.919 1.00 16.43 C ATOM 6040 CD2 LEU A 399 −48.191 19.304 −2.317 1.00 12.20 C ATOM 6044 C LEU A 399 −45.582 16.525 −4.578 1.00 14.68 C ATOM 6045 O LEU A 399 −46.043 16.784 −5.687 1.00 14.70 O ATOM 6047 N ILE A 400 −44.443 15.844 −4.419 1.00 14.92 N ATOM 6048 CA ILE A 400 −43.748 15.221 −5.564 1.00 15.08 C ATOM 6050 CB ILE A 400 −42.549 14.355 −5.129 1.00 15.35 C ATOM 6052 CG1 ILE A 400 −41.406 15.254 −4.611 1.00 16.83 C ATOM 6055 CD1 ILE A 400 −40.234 14.490 −3.958 1.00 17.18 C ATOM 6059 CG2 ILE A 400 −42.060 13.486 −6.292 1.00 14.03 C ATOM 6063 C ILE A 400 −44.682 14.329 −6.358 1.00 15.08 C ATOM 6064 O ILE A 400 −44.672 14.362 −7.574 1.00 15.18 O ATOM 6066 N PHE A 401 −45.474 13.524 −5.650 1.00 15.16 N ATOM 6067 CA PHE A 401 −46.501 12.674 −6.258 1.00 14.90 C ATOM 6069 CB PHE A 401 −47.052 11.663 −5.240 1.00 14.51 C ATOM 6072 CG PHE A 401 −46.294 10.378 −5.201 1.00 12.92 C ATOM 6073 CD1 PHE A 401 −46.727 9.282 −5.931 1.00 11.98 C ATOM 6075 CE1 PHE A 401 −46.032 8.093 −5.917 1.00 11.20 C ATOM 6077 CZ PHE A 401 −44.881 7.985 −5.165 1.00 12.03 C ATOM 6079 CE2 PHE A 401 −44.431 9.078 −4.428 1.00 11.98 C ATOM 6081 CD2 PHE A 401 −45.143 10.263 −4.453 1.00 12.09 C ATOM 6083 C PHE A 401 −47.641 13.509 −6.806 1.00 15.39 C ATOM 6084 O PHE A 401 −48.183 13.215 −7.858 1.00 15.51 O ATOM 6086 N ALA A 402 −48.022 14.545 −6.080 1.00 16.15 N ATOM 6087 CA ALA A 402 −49.110 15.393 −6.525 1.00 16.90 C ATOM 6089 CB ALA A 402 −49.391 16.473 −5.505 1.00 16.99 C ATOM 6093 C ALA A 402 −48.722 16.003 −7.856 1.00 17.50 C ATOM 6094 O ALA A 402 −49.549 16.100 −8.770 1.00 17.48 O ATOM 6096 N TYR A 403 −47.444 16.367 −7.963 1.00 18.28 N ATOM 6097 CA TYR A 403 −46.916 17.046 −9.142 1.00 18.94 C ATOM 6099 CB TYR A 403 −45.412 17.252 −9.043 1.00 19.03 C ATOM 6102 CG TYR A 403 −44.823 17.801 −10.314 1.00 19.79 C ATOM 6103 CD1 TYR A 403 −44.973 19.138 −10.652 1.00 20.80 C ATOM 6105 CE1 TYR A 403 −44.436 19.643 −11.827 1.00 20.73 C ATOM 6107 CZ TYR A 403 −43.759 18.804 −12.674 1.00 21.16 C ATOM 6108 OH TYR A 403 −43.231 19.283 −13.836 1.00 22.98 O ATOM 6110 CE2 TYR A 403 −43.608 17.476 −12.370 1.00 21.23 C ATOM 6112 CD2 TYR A 403 −44.137 16.980 −11.195 1.00 20.93 C ATOM 6114 C TYR A 403 −47.198 16.293 −10.413 1.00 19.39 C ATOM 6115 O TYR A 403 −47.567 16.904 −11.422 1.00 19.57 O ATOM 6117 N PHE A 404 −47.023 14.976 −10.376 1.00 19.74 N ATOM 6118 CA PHE A 404 −47.239 14.177 −11.573 1.00 20.35 C ATOM 6120 CB PHE A 404 −46.533 12.841 −11.466 1.00 19.96 C ATOM 6123 CG PHE A 404 −45.048 12.971 −11.387 1.00 18.81 C ATOM 6124 CD1 PHE A 404 −44.292 13.115 −12.528 1.00 17.42 C ATOM 6126 CE1 PHE A 404 −42.935 13.239 −12.457 1.00 17.24 C ATOM 6128 CZ PHE A 404 −42.312 13.237 −11.237 1.00 17.40 C ATOM 6130 CE2 PHE A 404 −43.056 13.106 −10.093 1.00 17.72 C ATOM 6132 CD2 PHE A 404 −44.413 12.975 −10.170 1.00 17.93 C ATOM 6134 C PHE A 404 −48.713 13.994 −11.894 1.00 21.59 C ATOM 6135 O PHE A 404 −49.072 13.717 −13.046 1.00 21.71 O ATOM 6137 N ALA A 405 −49.572 14.169 −10.896 1.00 22.87 N ATOM 6138 CA ALA A 405 −50.990 13.939 −11.099 1.00 24.06 C ATOM 6140 CB ALA A 405 −51.604 13.408 −9.833 1.00 24.15 C ATOM 6144 C ALA A 405 −51.724 15.192 −11.556 1.00 25.21 C ATOM 6145 O ALA A 405 −52.876 15.114 −11.939 1.00 25.51 O ATOM 6147 N VAL A 406 −51.056 16.336 −11.530 1.00 26.52 N ATOM 6148 CA VAL A 406 −51.713 17.617 −11.759 1.00 27.68 C ATOM 6150 CB VAL A 406 −51.694 18.406 −10.434 1.00 27.60 C ATOM 6152 CG1 VAL A 406 −51.654 19.913 −10.663 1.00 28.07 C ATOM 6156 CG2 VAL A 406 −52.883 18.009 −9.596 1.00 27.41 C ATOM 6160 C VAL A 406 −51.097 18.429 −12.925 1.00 29.10 C ATOM 6161 O VAL A 406 −51.810 19.104 −13.678 1.00 28.53 O ATOM 6163 N VAL A 407 −49.772 18.356 −13.059 1.00 30.90 N ATOM 6164 CA VAL A 407 −49.052 19.003 −14.151 1.00 32.15 C ATOM 6166 CB VAL A 407 −47.574 19.228 −13.777 1.00 32.25 C ATOM 6168 CG1 VAL A 407 −46.770 19.780 −14.964 1.00 32.22 C ATOM 6172 CG2 VAL A 407 −47.490 20.154 −12.583 1.00 32.25 C ATOM 6176 C VAL A 407 −49.134 18.160 −15.421 1.00 33.36 C ATOM 6177 O VAL A 407 −48.688 17.009 −15.454 1.00 33.40 O ATOM 6179 N GLN A 408 −49.693 18.767 −16.463 1.00 34.93 N ATOM 6180 CA GLN A 408 −49.930 18.102 −17.749 1.00 36.16 C ATOM 6182 CB GLN A 408 −50.779 19.016 −18.638 1.00 36.63 C ATOM 6185 CG GLN A 408 −51.625 18.270 −19.672 1.00 38.95 C ATOM 6188 CD GLN A 408 −52.991 18.930 −19.887 1.00 41.80 C ATOM 6189 OE1 GLN A 408 −53.739 19.150 −18.921 1.00 43.40 O ATOM 6190 NE2 GLN A 408 −53.323 19.244 −21.151 1.00 41.68 N ATOM 6193 C GLN A 408 −48.630 17.725 −18.470 1.00 36.22 C ATOM 6194 O GLN A 408 −48.456 16.588 −18.920 1.00 35.86 O ATOM 6196 N ASN A 409 −47.726 18.694 −18.578 1.00 36.64 N ATOM 6197 CA ASN A 409 −46.400 18.441 −19.136 1.00 36.85 C ATOM 6199 CB ASN A 409 −46.134 19.306 −20.373 1.00 36.73 C ATOM 6202 CG ASN A 409 −46.808 18.752 −21.604 1.00 36.19 C ATOM 6203 OD1 ASN A 409 −46.178 18.072 −22.420 1.00 35.00 O ATOM 6204 ND2 ASN A 409 −48.110 18.994 −21.720 1.00 34.99 N ATOM 6207 C ASN A 409 −45.312 18.613 −18.095 1.00 36.96 C ATOM 6208 O ASN A 409 −45.032 19.720 −17.618 1.00 36.81 O ATOM 6210 N ILE A 410 −44.713 17.488 −17.734 1.00 37.10 N ATOM 6211 CA ILE A 410 −43.625 17.508 −16.792 1.00 37.27 C ATOM 6213 CB ILE A 410 −43.265 16.092 −16.295 1.00 37.38 C ATOM 6215 CG1 ILE A 410 −42.745 15.209 −17.426 1.00 37.84 C ATOM 6218 CD1 ILE A 410 −42.416 13.824 −16.985 1.00 38.96 C ATOM 6222 CG2 ILE A 410 −44.491 15.437 −15.676 1.00 37.67 C ATOM 6226 C ILE A 410 −42.467 18.179 −17.492 1.00 37.12 C ATOM 6227 O ILE A 410 −42.150 17.839 −18.617 1.00 36.87 O ATOM 6229 N LYS A 411 −41.896 19.187 −16.851 1.00 37.38 N ATOM 6230 CA LYS A 411 −40.680 19.813 −17.332 1.00 37.73 C ATOM 6232 CB LYS A 411 −40.756 21.332 −17.171 1.00 38.15 C ATOM 6235 CG LYS A 411 −41.979 21.962 −17.837 1.00 39.89 C ATOM 6238 CD LYS A 411 −41.797 23.463 −18.080 1.00 42.48 C ATOM 6241 CE LYS A 411 −43.029 24.069 −18.795 1.00 44.22 C ATOM 6244 NZ LYS A 411 −42.977 25.576 −18.904 1.00 45.31 N ATOM 6248 C LYS A 411 −39.562 19.244 −16.489 1.00 37.38 C ATOM 6249 O LYS A 411 −39.721 19.112 −15.281 1.00 37.28 O ATOM 6251 N LYS A 412 −38.445 18.886 −17.122 1.00 37.24 N ATOM 6252 CA LYS A 412 −37.333 18.243 −16.413 1.00 36.95 C ATOM 6254 CB LYS A 412 −36.286 17.701 −17.384 1.00 37.14 C ATOM 6257 CG LYS A 412 −35.233 16.818 −16.720 1.00 37.89 C ATOM 6260 CD LYS A 412 −34.334 16.125 −17.757 1.00 39.54 C ATOM 6263 CE LYS A 412 −33.263 17.068 −18.348 1.00 40.08 C ATOM 6266 NZ LYS A 412 −32.161 17.399 −17.376 1.00 40.16 N ATOM 6270 C LYS A 412 −36.664 19.177 −15.419 1.00 36.42 C ATOM 6271 O LYS A 412 −36.246 18.728 −14.357 1.00 36.56 O ATOM 6273 N GLU A 413 −36.570 20.466 −15.744 1.00 35.77 N ATOM 6274 CA GLU A 413 −35.948 21.423 −14.820 1.00 35.38 C ATOM 6276 CB GLU A 413 −35.688 22.792 −15.489 1.00 35.73 C ATOM 6279 CG GLU A 413 −36.510 24.013 −14.973 1.00 37.10 C ATOM 6282 CD GLU A 413 −35.621 25.235 −14.633 1.00 38.51 C ATOM 6283 OE1 GLU A 413 −34.778 25.125 −13.714 1.00 39.24 O ATOM 6284 OE2 GLU A 413 −35.768 26.306 −15.266 1.00 39.04 O ATOM 6285 C GLU A 413 −36.760 21.551 −13.522 1.00 34.43 C ATOM 6286 O GLU A 413 −36.196 21.801 −12.460 1.00 34.34 O ATOM 6288 N GLU A 414 −38.074 21.360 −13.616 1.00 33.45 N ATOM 6289 CA GLU A 414 −38.956 21.407 −12.452 1.00 32.80 C ATOM 6291 CB GLU A 414 −40.435 21.425 −12.864 1.00 32.83 C ATOM 6294 CG GLU A 414 −40.923 22.736 −13.478 1.00 33.15 C ATOM 6297 CD GLU A 414 −42.360 22.668 −14.003 1.00 33.82 C ATOM 6298 OE1 GLU A 414 −42.876 21.560 −14.231 1.00 35.31 O ATOM 6299 OE2 GLU A 414 −42.985 23.727 −14.204 1.00 33.98 O ATOM 6300 C GLU A 414 −38.715 20.222 −11.536 1.00 32.18 C ATOM 6301 O GLU A 414 −38.407 20.409 −10.372 1.00 32.25 O ATOM 6303 N ILE A 415 −38.863 19.002 −12.044 1.00 31.63 N ATOM 6304 CA ILE A 415 −38.725 17.819 −11.181 1.00 31.28 C ATOM 6306 CB ILE A 415 −39.131 16.472 −11.852 1.00 31.14 C ATOM 6308 CG1 ILE A 415 −38.349 16.204 −13.133 1.00 31.13 C ATOM 6311 CD1 ILE A 415 −38.786 14.926 −13.836 1.00 30.72 C ATOM 6315 CG2 ILE A 415 −40.611 16.454 −12.160 1.00 31.12 C ATOM 6319 C ILE A 415 −37.316 17.705 −10.636 1.00 31.08 C ATOM 6320 O ILE A 415 −37.105 17.188 −9.539 1.00 31.22 O ATOM 6322 N GLU A 416 −36.345 18.208 −11.381 1.00 30.67 N ATOM 6323 CA GLU A 416 −34.998 18.270 −10.850 1.00 30.55 C ATOM 6325 CB GLU A 416 −34.011 18.654 −11.955 1.00 30.91 C ATOM 6328 CG GLU A 416 −32.654 17.967 −11.845 1.00 32.55 C ATOM 6331 CD GLU A 416 −31.802 18.130 −13.109 1.00 34.91 C ATOM 6332 OE1 GLU A 416 −32.337 18.563 −14.161 1.00 35.53 O ATOM 6333 OE2 GLU A 416 −30.590 17.816 −13.052 1.00 36.45 O ATOM 6334 C GLU A 416 −34.962 19.249 −9.650 1.00 29.74 C ATOM 6335 O GLU A 416 −34.143 19.097 −8.738 1.00 29.73 O ATOM 6337 N ASN A 417 −35.864 20.234 −9.652 1.00 28.69 N ATOM 6338 CA ASN A 417 −36.060 21.134 −8.503 1.00 27.92 C ATOM 6340 CB ASN A 417 −36.632 22.477 −8.963 1.00 27.75 C ATOM 6343 CG ASN A 417 −35.572 23.532 −9.095 1.00 26.84 C ATOM 6344 OD1 ASN A 417 −35.160 24.132 −8.105 1.00 24.88 O ATOM 6345 ND2 ASN A 417 −35.117 23.765 −10.318 1.00 26.28 N ATOM 6348 C ASN A 417 −36.917 20.580 −7.356 1.00 27.41 C ATOM 6349 O ASN A 417 −36.650 20.838 −6.187 1.00 27.15 O ATOM 6351 N LEU A 418 −37.955 19.834 −7.675 1.00 27.09 N ATOM 6352 CA LEU A 418 −38.694 19.156 −6.628 1.00 27.02 C ATOM 6354 CB LEU A 418 −39.921 18.423 −7.200 1.00 26.95 C ATOM 6357 CG LEU A 418 −41.030 19.284 −7.826 1.00 25.97 C ATOM 6359 CD1 LEU A 418 −42.127 18.429 −8.447 1.00 24.88 C ATOM 6363 CD2 LEU A 418 −41.623 20.226 −6.803 1.00 24.50 C ATOM 6367 C LEU A 418 −37.763 18.196 −5.860 1.00 27.26 C ATOM 6368 O LEU A 418 −37.834 18.123 −4.644 1.00 27.07 O ATOM 6370 N GLN A 419 −36.873 17.494 −6.561 1.00 27.67 N ATOM 6371 CA GLN A 419 −35.924 16.575 −5.909 1.00 28.28 C ATOM 6373 CB GLN A 419 −35.155 15.758 −6.945 1.00 28.36 C ATOM 6376 CG GLN A 419 −35.747 14.375 −7.146 1.00 29.43 C ATOM 6379 CD GLN A 419 −35.052 13.573 −8.215 1.00 29.76 C ATOM 6380 OE1 GLN A 419 −34.355 14.112 −9.066 1.00 29.93 O ATOM 6381 NE2 GLN A 419 −35.252 12.270 −8.184 1.00 31.33 N ATOM 6384 C GLN A 419 −34.922 17.219 −4.947 1.00 28.73 C ATOM 6385 O GLN A 419 −34.540 16.608 −3.952 1.00 28.90 O ATOM 6387 N LYS A 420 −34.490 18.440 −5.240 1.00 29.27 N ATOM 6388 CA LYS A 420 −33.608 19.166 −4.335 1.00 29.81 C ATOM 6390 CB LYS A 420 −32.758 20.163 −5.129 1.00 30.24 C ATOM 6393 CG LYS A 420 −31.592 19.513 −5.867 1.00 31.75 C ATOM 6396 CD LYS A 420 −31.259 20.217 −7.183 1.00 34.14 C ATOM 6399 CE LYS A 420 −30.140 19.463 −7.953 1.00 36.21 C ATOM 6402 NZ LYS A 420 −30.073 19.759 −9.439 1.00 36.76 N ATOM 6406 C LYS A 420 −34.375 19.872 −3.204 1.00 29.98 C ATOM 6407 O LYS A 420 −33.759 20.547 −2.384 1.00 30.44 O ATOM 6409 N TYR A 421 −35.706 19.694 −3.162 1.00 30.07 N ATOM 6410 CA TYR A 421 −36.646 20.309 −2.171 1.00 29.73 C ATOM 6412 CB TYR A 421 −36.298 19.949 −.712 1.00 29.59 C ATOM 6415 CG TYR A 421 −36.386 18.468 −.470 1.00 30.57 C ATOM 6416 CD1 TYR A 421 −37.582 17.785 −.643 1.00 30.87 C ATOM 6418 CE1 TYR A 421 −37.665 16.414 −.448 1.00 31.28 C ATOM 6420 CZ TYR A 421 −36.549 15.705 −.068 1.00 31.90 C ATOM 6421 OH TYR A 421 −36.620 14.347 .124 1.00 32.43 O ATOM 6423 CE2 TYR A 421 −35.355 16.354 .119 1.00 32.68 C ATOM 6425 CD2 TYR A 421 −35.274 17.736 −.095 1.00 32.42 C ATOM 6427 C TYR A 421 −36.850 21.816 −2.347 1.00 29.24 C ATOM 6428 O TYR A 421 −36.709 22.590 −1.401 1.00 29.26 O ATOM 6430 N HIS A 422 −37.219 22.214 −3.563 1.00 28.65 N ATOM 6431 CA HIS A 422 −37.540 23.604 −3.859 1.00 28.26 C ATOM 6433 CB HIS A 422 −38.150 23.715 −5.256 1.00 28.33 C ATOM 6436 CG HIS A 422 −38.299 25.124 −5.748 1.00 28.44 C ATOM 6437 ND1 HIS A 422 −37.225 25.904 −6.106 1.00 28.97 N ATOM 6439 CE1 HIS A 422 −37.660 27.082 −6.520 1.00 29.40 C ATOM 6441 NE2 HIS A 422 −38.977 27.090 −6.443 1.00 28.14 N ATOM 6443 CD2 HIS A 422 −39.399 25.879 −5.965 1.00 27.76 C ATOM 6445 C HIS A 422 −38.511 24.147 −2.816 1.00 27.74 C ATOM 6446 O HIS A 422 −39.357 23.408 −2.310 1.00 27.53 O ATOM 6448 N ASP A 423 −38.384 25.437 −2.505 1.00 27.12 N ATOM 6449 CA ASP A 423 −39.186 26.072 −1.454 1.00 26.63 C ATOM 6451 CB ASP A 423 −38.877 27.575 −1.349 1.00 27.05 C ATOM 6454 CG ASP A 423 −37.456 27.875 −.851 1.00 28.35 C ATOM 6455 OD1 ASP A 423 −36.951 27.121 .018 1.00 30.99 O ATOM 6456 OD2 ASP A 423 −36.860 28.884 −1.322 1.00 27.89 O ATOM 6457 C ASP A 423 −40.689 25.883 −1.698 1.00 25.71 C ATOM 6458 O ASP A 423 −41.487 25.831 −.749 1.00 26.26 O ATOM 6460 N ILE A 424 −41.075 25.781 −2.966 1.00 24.01 N ATOM 6461 CA ILE A 424 −42.479 25.596 −3.327 1.00 22.72 C ATOM 6463 CB ILE A 424 −42.639 25.391 −4.843 1.00 22.40 C ATOM 6465 CG1 ILE A 424 −44.029 25.668 −5.318 1.00 21.78 C ATOM 6468 CD1 ILE A 424 −44.086 25.499 −6.793 1.00 22.22 C ATOM 6472 CG2 ILE A 424 −42.340 23.985 −5.255 1.00 22.87 C ATOM 6476 C ILE A 424 −43.103 24.442 −2.562 1.00 21.91 C ATOM 6477 O ILE A 424 −44.238 24.574 −2.115 1.00 21.73 O ATOM 6479 N ILE A 425 −42.365 23.334 −2.399 1.00 21.23 N ATOM 6480 CA ILE A 425 −42.853 22.173 −1.634 1.00 20.73 C ATOM 6482 CB ILE A 425 −42.622 20.820 −2.330 1.00 20.10 C ATOM 6484 CG1 ILE A 425 −41.158 20.409 −2.290 1.00 18.72 C ATOM 6487 CD1 ILE A 425 −40.923 19.075 −2.948 1.00 18.27 C ATOM 6491 CG2 ILE A 425 −43.146 20.840 −3.741 1.00 19.57 C ATOM 6495 C ILE A 425 −42.252 22.060 −.242 1.00 21.21 C ATOM 6496 O ILE A 425 −42.810 21.370 .613 1.00 21.30 O ATOM 6498 N SER A 426 −41.129 22.721 −.002 1.00 21.56 N ATOM 6499 CA SER A 426 −40.492 22.620 1.299 1.00 22.23 C ATOM 6501 CB SER A 426 −39.043 23.082 1.234 1.00 22.36 C ATOM 6504 OG SER A 426 −38.977 24.501 1.342 1.00 24.09 O ATOM 6506 C SER A 426 −41.242 23.460 2.334 1.00 22.39 C ATOM 6507 O SER A 426 −41.390 23.051 3.491 1.00 22.95 O ATOM 6509 N ARG A 427 −41.701 24.643 1.937 1.00 22.08 N ATOM 6510 CA ARG A 427 −42.332 25.541 2.905 1.00 21.87 C ATOM 6512 CB ARG A 427 −42.466 26.955 2.345 1.00 21.99 C ATOM 6515 CG ARG A 427 −41.170 27.696 2.493 1.00 23.36 C ATOM 6518 CD ARG A 427 −40.954 28.727 1.433 1.00 26.07 C ATOM 6521 NE ARG A 427 −39.680 29.407 1.667 1.00 28.18 N ATOM 6523 CZ ARG A 427 −39.127 30.298 .844 1.00 29.21 C ATOM 6524 NH1 ARG A 427 −39.723 30.633 −.298 1.00 28.60 N ATOM 6527 NH2 ARG A 427 −37.962 30.854 1.173 1.00 30.48 N ATOM 6530 C ARG A 427 −43.651 25.003 3.434 1.00 21.21 C ATOM 6531 O ARG A 427 −43.817 24.891 4.645 1.00 21.11 O ATOM 6533 N PRO A 428 −44.573 24.622 2.541 1.00 20.52 N ATOM 6534 CA PRO A 428 −45.789 23.999 3.040 1.00 20.27 C ATOM 6536 CB PRO A 428 −46.410 23.369 1.791 1.00 20.44 C ATOM 6539 CG PRO A 428 −45.864 24.119 .666 1.00 20.63 C ATOM 6542 CD PRO A 428 −44.521 24.644 1.074 1.00 20.54 C ATOM 6545 C PRO A 428 −45.450 22.917 4.050 1.00 19.75 C ATOM 6546 O PRO A 428 −46.089 22.834 5.095 1.00 19.77 O ATOM 6547 N SER A 429 −44.424 22.123 3.747 1.00 18.97 N ATOM 6548 CA SER A 429 −44.008 21.045 4.636 1.00 18.45 C ATOM 6550 CB SER A 429 −42.954 20.180 3.972 1.00 18.35 C ATOM 6553 OG SER A 429 −43.452 19.716 2.733 1.00 19.12 O ATOM 6555 C SER A 429 −43.519 21.525 5.985 1.00 17.97 C ATOM 6556 O SER A 429 −43.733 20.846 6.968 1.00 17.88 O ATOM 6558 N HIS A 430 −42.879 22.689 6.053 1.00 17.73 N ATOM 6559 CA HIS A 430 −42.593 23.289 7.359 1.00 17.71 C ATOM 6561 CB HIS A 430 −41.937 24.668 7.241 1.00 17.97 C ATOM 6564 CG HIS A 430 −40.558 24.663 6.651 1.00 18.87 C ATOM 6565 ND1 HIS A 430 −39.940 23.524 6.186 1.00 19.85 N ATOM 6567 CE1 HIS A 430 −38.746 23.836 5.709 1.00 19.43 C ATOM 6569 NE2 HIS A 430 −38.573 25.137 5.838 1.00 19.06 N ATOM 6571 CD2 HIS A 430 −39.693 25.681 6.418 1.00 19.32 C ATOM 6573 C HIS A 430 −43.914 23.444 8.131 1.00 17.31 C ATOM 6574 O HIS A 430 −44.023 23.013 9.287 1.00 17.06 O ATOM 6576 N ILE A 431 −44.913 24.050 7.475 1.00 16.74 N ATOM 6577 CA ILE A 431 −46.218 24.304 8.091 1.00 16.15 C ATOM 6579 CB ILE A 431 −47.174 25.057 7.174 1.00 16.18 C ATOM 6581 CG1 ILE A 431 −46.613 26.428 6.801 1.00 17.05 C ATOM 6584 CD1 ILE A 431 −46.441 27.352 7.994 1.00 18.34 C ATOM 6588 CG2 ILE A 431 −48.496 25.263 7.860 1.00 15.28 C ATOM 6592 C ILE A 431 −46.899 23.021 8.476 1.00 15.75 C ATOM 6593 O ILE A 431 −47.624 22.980 9.445 1.00 15.95 O ATOM 6595 N PHE A 432 −46.663 21.969 7.714 1.00 15.59 N ATOM 6596 CA PHE A 432 −47.192 20.652 8.041 1.00 15.52 C ATOM 6598 CB PHE A 432 −46.837 19.683 6.913 1.00 15.23 C ATOM 6601 CG PHE A 432 −47.451 18.318 7.031 1.00 15.98 C ATOM 6602 CD1 PHE A 432 −48.324 17.972 8.052 1.00 16.55 C ATOM 6604 CE1 PHE A 432 −48.867 16.700 8.102 1.00 16.04 C ATOM 6606 CZ PHE A 432 −48.559 15.774 7.130 1.00 15.29 C ATOM 6608 CE2 PHE A 432 −47.718 16.107 6.114 1.00 15.37 C ATOM 6610 CD2 PHE A 432 −47.172 17.364 6.061 1.00 16.74 C ATOM 6612 C PHE A 432 −46.640 20.191 9.392 1.00 15.54 C ATOM 6613 O PHE A 432 −47.383 20.006 10.343 1.00 15.37 O ATOM 6615 N ARG A 433 −45.328 20.041 9.483 1.00 15.98 N ATOM 6616 CA ARG A 433 −44.695 19.542 10.709 1.00 16.20 C ATOM 6618 CB ARG A 433 −43.176 19.476 10.526 1.00 15.85 C ATOM 6621 CG ARG A 433 −42.411 19.183 11.804 1.00 16.11 C ATOM 6624 CD ARG A 433 −42.848 17.890 12.489 1.00 15.70 C ATOM 6627 NE ARG A 433 −42.811 16.747 11.588 1.00 15.64 N ATOM 6629 CZ ARG A 433 −43.377 15.571 11.838 1.00 16.27 C ATOM 6630 NH1 ARG A 433 −44.029 15.359 12.965 1.00 16.82 N ATOM 6633 NH2 ARG A 433 −43.302 14.598 10.948 1.00 16.96 N ATOM 6636 C ARG A 433 −45.029 20.411 11.935 1.00 16.46 C ATOM 6637 O ARG A 433 −45.296 19.890 13.031 1.00 16.31 O ATOM 6639 N LEU A 434 −45.006 21.731 11.724 1.00 16.47 N ATOM 6640 CA LEU A 434 −45.123 22.701 12.800 1.00 15.98 C ATOM 6642 CB LEU A 434 −44.771 24.114 12.303 1.00 15.83 C ATOM 6645 CG LEU A 434 −43.287 24.486 12.218 1.00 14.95 C ATOM 6647 CD1 LEU A 434 −43.130 25.918 11.826 1.00 15.09 C ATOM 6651 CD2 LEU A 434 −42.600 24.281 13.536 1.00 14.37 C ATOM 6655 C LEU A 434 −46.517 22.660 13.387 1.00 16.19 C ATOM 6656 O LEU A 434 −46.669 22.564 14.604 1.00 15.92 O ATOM 6658 N CYS A 435 −47.529 22.715 12.520 1.00 16.78 N ATOM 6659 CA CYS A 435 −48.936 22.591 12.940 1.00 17.48 C ATOM 6661 CB CYS A 435 −49.870 22.617 11.726 1.00 17.54 C ATOM 6664 SG CYS A 435 −50.110 24.233 10.985 1.00 18.80 S ATOM 6666 C CYS A 435 −49.192 21.296 13.708 1.00 17.84 C ATOM 6667 O CYS A 435 −50.043 21.250 14.597 1.00 17.92 O ATOM 6669 N ASN A 436 −48.446 20.257 13.333 1.00 18.24 N ATOM 6670 CA ASN A 436 −48.603 18.913 13.846 1.00 18.50 C ATOM 6672 CB ASN A 436 −47.936 17.949 12.867 1.00 18.63 C ATOM 6675 CG ASN A 436 −48.156 16.487 13.213 1.00 18.58 C ATOM 6676 OD1 ASN A 436 −48.810 16.129 14.185 1.00 18.80 O ATOM 6677 ND2 ASN A 436 −47.588 15.633 12.398 1.00 19.29 N ATOM 6680 C ASN A 436 −47.975 18.755 15.210 1.00 18.83 C ATOM 6681 O ASN A 436 −48.551 18.153 16.115 1.00 19.00 O ATOM 6683 N ASP A 437 −46.763 19.255 15.351 1.00 19.29 N ATOM 6684 CA ASP A 437 −46.097 19.179 16.634 1.00 19.62 C ATOM 6686 CB ASP A 437 −44.615 19.522 16.510 1.00 19.45 C ATOM 6689 CG ASP A 437 −43.849 18.480 15.734 1.00 19.36 C ATOM 6690 OD1 ASP A 437 −44.491 17.586 15.158 1.00 19.89 O ATOM 6691 OD2 ASP A 437 −42.608 18.543 15.699 1.00 19.86 O ATOM 6692 C ASP A 437 −46.799 20.106 17.597 1.00 20.01 C ATOM 6693 O ASP A 437 −46.916 19.790 18.779 1.00 20.30 O ATOM 6695 N LEU A 438 −47.288 21.233 17.092 1.00 20.40 N ATOM 6696 CA LEU A 438 −47.996 22.174 17.940 1.00 21.03 C ATOM 6698 CB LEU A 438 −48.510 23.363 17.126 1.00 21.01 C ATOM 6701 CG LEU A 438 −47.575 24.565 17.078 1.00 20.32 C ATOM 6703 CD1 LEU A 438 −47.938 25.524 15.952 1.00 19.14 C ATOM 6707 CD2 LEU A 438 −47.611 25.263 18.415 1.00 19.73 C ATOM 6711 C LEU A 438 −49.153 21.496 18.679 1.00 21.81 C ATOM 6712 O LEU A 438 −49.277 21.633 19.902 1.00 21.55 O ATOM 6714 N ALA A 439 −49.973 20.754 17.932 1.00 22.76 N ATOM 6715 CA ALA A 439 −51.138 20.055 18.486 1.00 23.58 C ATOM 6717 CB ALA A 439 −51.905 19.360 17.386 1.00 23.57 C ATOM 6721 C ALA A 439 −50.746 19.042 19.542 1.00 24.47 C ATOM 6722 O ALA A 439 −51.386 18.951 20.575 1.00 24.63 O ATOM 6724 N SER A 440 −49.685 18.291 19.276 1.00 25.78 N ATOM 6725 CA SER A 440 −49.242 17.227 20.168 1.00 26.84 C ATOM 6727 CB SER A 440 −48.566 16.130 19.353 1.00 26.92 C ATOM 6730 OG SER A 440 −47.321 16.582 18.859 1.00 27.46 O ATOM 6732 C SER A 440 −48.270 17.691 21.244 1.00 27.68 C ATOM 6733 O SER A 440 −47.934 16.923 22.132 1.00 28.00 O ATOM 6735 N ALA A 441 −47.822 18.935 21.174 1.00 28.83 N ATOM 6736 CA ALA A 441 −46.760 19.419 22.056 1.00 29.73 C ATOM 6738 CB ALA A 441 −46.529 20.910 21.841 1.00 29.84 C ATOM 6742 C ALA A 441 −46.982 19.132 23.539 1.00 30.57 C ATOM 6743 O ALA A 441 −46.306 18.274 24.093 1.00 30.50 O ATOM 6745 N SER A 442 −47.929 19.827 24.172 1.00 31.90 N ATOM 6746 CA SER A 442 −47.999 19.862 25.654 1.00 32.95 C ATOM 6748 CB SER A 442 −49.043 20.870 26.169 1.00 32.91 C ATOM 6751 OG SER A 442 −50.331 20.614 25.650 1.00 33.50 O ATOM 6753 C SER A 442 −48.219 18.497 26.289 1.00 33.69 C ATOM 6754 O SER A 442 −47.754 18.246 27.397 1.00 33.59 O ATOM 6756 N ALA A 443 −48.922 17.623 25.578 1.00 34.93 N ATOM 6757 CA ALA A 443 −49.050 16.231 25.980 1.00 35.81 C ATOM 6759 CB ALA A 443 −49.981 15.488 25.030 1.00 35.72 C ATOM 6763 C ALA A 443 −47.663 15.580 25.996 1.00 36.71 C ATOM 6764 O ALA A 443 −47.198 15.115 27.047 1.00 36.94 O ATOM 6766 N GLU A 444 −46.999 15.567 24.838 1.00 37.47 N ATOM 6767 CA GLU A 444 −45.688 14.930 24.718 1.00 37.93 C ATOM 6769 CB GLU A 444 −45.164 14.996 23.277 1.00 37.99 C ATOM 6772 CG GLU A 444 −45.952 14.100 22.326 1.00 39.24 C ATOM 6775 CD GLU A 444 −45.419 14.080 20.886 1.00 41.03 C ATOM 6776 OE1 GLU A 444 −44.612 14.958 20.510 1.00 42.16 O ATOM 6777 OE2 GLU A 444 −45.827 13.178 20.119 1.00 42.36 O ATOM 6778 C GLU A 444 −44.694 15.534 25.708 1.00 38.09 C ATOM 6779 O GLU A 444 −43.924 14.803 26.324 1.00 38.17 O ATOM 6781 N ILE A 445 −44.739 16.851 25.889 1.00 38.41 N ATOM 6782 CA ILE A 445 −43.829 17.530 26.814 1.00 38.75 C ATOM 6784 CB ILE A 445 −43.802 19.065 26.587 1.00 38.69 C ATOM 6786 CG1 ILE A 445 −43.314 19.396 25.170 1.00 38.18 C ATOM 6789 CD1 ILE A 445 −43.702 20.775 24.712 1.00 37.58 C ATOM 6793 CG2 ILE A 445 −42.909 19.753 27.617 1.00 38.26 C ATOM 6797 C ILE A 445 −44.243 17.194 28.246 1.00 39.35 C ATOM 6798 O ILE A 445 −45.039 17.901 28.870 1.00 39.44 O ATOM 6800 N ALA A 446 −43.696 16.092 28.750 1.00 40.02 N ATOM 6801 CA ALA A 446 −44.082 15.540 30.045 1.00 40.51 C ATOM 6803 CB ALA A 446 −43.815 16.552 31.170 1.00 40.55 C ATOM 6807 C ALA A 446 −45.559 15.130 30.029 1.00 40.86 C ATOM 6808 O ALA A 446 −46.407 16.021 30.121 1.00 40.77 O ATOM 6810 N ARG A 447 −45.925 13.842 29.899 1.00 41.31 N ATOM 6811 CA ARG A 447 −45.072 12.633 29.691 1.00 41.58 C ATOM 6813 CB ARG A 447 −45.272 12.092 28.258 1.00 41.84 C ATOM 6816 CG ARG A 447 −46.667 11.495 27.991 1.00 42.69 C ATOM 6819 CD ARG A 447 −46.778 10.901 26.582 1.00 43.92 C ATOM 6822 NE ARG A 447 −47.764 11.589 25.744 1.00 45.34 N ATOM 6824 CZ ARG A 447 −47.887 11.435 24.420 1.00 46.56 C ATOM 6825 NH1 ARG A 447 −47.077 10.623 23.742 1.00 46.71 N ATOM 6828 NH2 ARG A 447 −48.828 12.107 23.757 1.00 46.97 N ATOM 6831 C ARG A 447 −43.581 12.728 30.054 1.00 41.38 C ATOM 6832 O ARG A 447 −43.231 12.747 31.238 1.00 41.92 O ATOM 6834 N GLY A 448 −42.710 12.736 29.051 1.00 40.88 N ATOM 6835 CA GLY A 448 −41.312 13.128 29.234 1.00 40.44 C ATOM 6838 C GLY A 448 −40.579 13.316 27.915 1.00 40.08 C ATOM 6839 O GLY A 448 −39.364 13.488 27.901 1.00 40.05 O ATOM 6841 N GLU A 449 −41.323 13.332 26.809 1.00 39.56 N ATOM 6842 CA GLU A 449 −40.750 13.132 25.486 1.00 39.19 C ATOM 6844 CB GLU A 449 −41.827 12.668 24.502 1.00 39.52 C ATOM 6847 CG GLU A 449 −42.403 11.290 24.810 1.00 40.61 C ATOM 6850 CD GLU A 449 −43.348 10.782 23.715 1.00 42.21 C ATOM 6851 OE1 GLU A 449 −43.068 11.019 22.503 1.00 41.83 O ATOM 6852 OE2 GLU A 449 −44.368 10.141 24.082 1.00 42.41 O ATOM 6853 C GLU A 449 −40.037 14.365 24.921 1.00 38.34 C ATOM 6854 O GLU A 449 −40.511 15.497 25.031 1.00 38.01 O ATOM 6856 N THR A 450 −38.904 14.106 24.279 1.00 37.37 N ATOM 6857 CA THR A 450 −38.047 15.138 23.726 1.00 36.37 C ATOM 6859 CB THR A 450 −36.607 14.985 24.285 1.00 36.39 C ATOM 6861 OG1 THR A 450 −35.846 16.153 23.982 1.00 36.63 O ATOM 6863 CG2 THR A 450 −35.888 13.749 23.706 1.00 36.52 C ATOM 6867 C THR A 450 −38.013 15.100 22.190 1.00 35.36 C ATOM 6868 O THR A 450 −37.175 15.764 21.583 1.00 35.43 O ATOM 6870 N ALA A 451 −38.917 14.338 21.563 1.00 33.98 N ATOM 6871 CA ALA A 451 −38.920 14.182 20.096 1.00 32.81 C ATOM 6873 CB ALA A 451 −39.030 12.708 19.708 1.00 32.99 C ATOM 6877 C ALA A 451 −40.043 14.987 19.459 1.00 31.46 C ATOM 6878 O ALA A 451 −41.050 14.432 18.996 1.00 31.06 O ATOM 6880 N ASN A 452 −39.848 16.302 19.432 1.00 29.88 N ATOM 6881 CA ASN A 452 −40.881 17.225 18.973 1.00 28.81 C ATOM 6883 CB ASN A 452 −41.957 17.329 20.051 1.00 28.57 C ATOM 6886 CG ASN A 452 −42.969 18.380 19.757 1.00 28.30 C ATOM 6887 OD1 ASN A 452 −42.622 19.517 19.468 1.00 29.35 O ATOM 6888 ND2 ASN A 452 −44.236 18.018 19.836 1.00 28.36 N ATOM 6891 C ASN A 452 −40.285 18.590 18.641 1.00 27.76 C ATOM 6892 O ASN A 452 −39.365 19.018 19.296 1.00 28.04 O ATOM 6894 N SER A 453 −40.807 19.269 17.630 1.00 26.77 N ATOM 6895 CA SER A 453 −40.226 20.533 17.182 1.00 26.38 C ATOM 6897 CB SER A 453 −40.912 21.015 15.903 1.00 26.40 C ATOM 6900 OG SER A 453 −40.796 20.044 14.876 1.00 25.79 O ATOM 6902 C SER A 453 −40.253 21.643 18.233 1.00 26.12 C ATOM 6903 O SER A 453 −39.280 22.361 18.385 1.00 25.97 O ATOM 6905 N VAL A 454 −41.368 21.784 18.942 1.00 26.15 N ATOM 6906 CA VAL A 454 −41.518 22.780 20.022 1.00 26.21 C ATOM 6908 CB VAL A 454 −42.975 22.818 20.532 1.00 26.04 C ATOM 6910 CG1 VAL A 454 −43.122 23.787 21.694 1.00 25.24 C ATOM 6914 CG2 VAL A 454 −43.913 23.190 19.401 1.00 26.32 C ATOM 6918 C VAL A 454 −40.617 22.451 21.211 1.00 26.63 C ATOM 6919 O VAL A 454 −40.173 23.328 21.959 1.00 26.53 O ATOM 6921 N SER A 455 −40.374 21.160 21.380 1.00 27.21 N ATOM 6922 CA SER A 455 −39.541 20.651 22.437 1.00 27.60 C ATOM 6924 CB SER A 455 −39.677 19.141 22.490 1.00 27.31 C ATOM 6927 OG SER A 455 −38.922 18.625 23.545 1.00 28.13 O ATOM 6929 C SER A 455 −38.096 21.045 22.181 1.00 28.29 C ATOM 6930 O SER A 455 −37.445 21.628 23.043 1.00 28.63 O ATOM 6932 N CYS A 456 −37.599 20.748 20.988 1.00 29.04 N ATOM 6933 CA CYS A 456 −36.219 21.082 20.640 1.00 29.65 C ATOM 6935 CB CYS A 456 −35.868 20.535 19.256 1.00 29.52 C ATOM 6938 SG CYS A 456 −35.959 18.734 19.163 1.00 29.71 S ATOM 6940 C CYS A 456 −35.955 22.589 20.710 1.00 30.26 C ATOM 6941 O CYS A 456 −34.887 23.007 21.162 1.00 30.49 O ATOM 6943 N TYR A 457 −36.924 23.399 20.283 1.00 30.88 N ATOM 6944 CA TYR A 457 −36.767 24.850 20.308 1.00 31.45 C ATOM 6946 CB TYR A 457 −37.967 25.557 19.648 1.00 31.55 C ATOM 6949 CG TYR A 457 −37.691 26.991 19.178 1.00 32.09 C ATOM 6950 CD1 TYR A 457 −37.378 27.269 17.843 1.00 31.69 C ATOM 6952 CE1 TYR A 457 −37.128 28.569 17.418 1.00 31.73 C ATOM 6954 CZ TYR A 457 −37.186 29.613 18.328 1.00 32.84 C ATOM 6955 OH TYR A 457 −36.945 30.917 17.927 1.00 33.81 O ATOM 6957 CE2 TYR A 457 −37.492 29.364 19.658 1.00 32.72 C ATOM 6959 CD2 TYR A 457 −37.746 28.064 20.074 1.00 32.44 C ATOM 6961 C TYR A 457 −36.571 25.295 21.758 1.00 31.99 C ATOM 6962 O TYR A 457 −35.648 26.053 22.052 1.00 31.98 O ATOM 6964 N MET A 458 −37.419 24.799 22.661 1.00 32.76 N ATOM 6965 CA MET A 458 −37.211 24.987 24.105 1.00 33.37 C ATOM 6967 CB MET A 458 −38.151 24.097 24.921 1.00 33.43 C ATOM 6970 CG MET A 458 −39.570 24.593 25.059 1.00 33.70 C ATOM 6973 SD MET A 458 −40.641 23.312 25.737 1.00 34.59 S ATOM 6974 CE MET A 458 −39.709 22.763 27.179 1.00 34.71 C ATOM 6978 C MET A 458 −35.784 24.641 24.517 1.00 33.78 C ATOM 6979 O MET A 458 −35.101 25.437 25.151 1.00 33.73 O ATOM 6981 N ARG A 459 −35.347 23.445 24.145 1.00 34.46 N ATOM 6982 CA ARG A 459 −34.051 22.926 24.581 1.00 35.15 C ATOM 6984 CB ARG A 459 −33.876 21.447 24.171 1.00 35.68 C ATOM 6987 CG ARG A 459 −32.494 20.864 24.500 1.00 37.23 C ATOM 6990 CD ARG A 459 −32.491 19.345 24.752 1.00 39.80 C ATOM 6993 NE ARG A 459 −33.140 18.538 23.711 1.00 42.88 N ATOM 6995 CZ ARG A 459 −32.704 18.407 22.453 1.00 45.43 C ATOM 6996 NH1 ARG A 459 −31.615 19.062 22.035 1.00 47.50 N ATOM 6999 NH2 ARG A 459 −33.366 17.629 21.595 1.00 44.77 N ATOM 7002 C ARG A 459 −32.878 23.749 24.072 1.00 34.92 C ATOM 7003 O ARG A 459 −32.007 24.109 24.849 1.00 35.06 O ATOM 7005 N THR A 460 −32.854 24.047 22.778 1.00 34.96 N ATOM 7006 CA THR A 460 −31.674 24.678 22.163 1.00 34.91 C ATOM 7008 CB THR A 460 −31.494 24.263 20.680 1.00 34.88 C ATOM 7010 OG1 THR A 460 −32.330 25.067 19.841 1.00 34.39 O ATOM 7012 CG2 THR A 460 −31.825 22.776 20.488 1.00 35.44 C ATOM 7016 C THR A 460 −31.672 26.210 22.258 1.00 34.78 C ATOM 7017 O THR A 460 −30.673 26.837 21.911 1.00 34.92 O ATOM 7019 N LYS A 461 −32.781 26.806 22.701 1.00 34.41 N ATOM 7020 CA LYS A 461 −32.811 28.231 23.039 1.00 34.25 C ATOM 7022 CB LYS A 461 −33.921 28.947 22.265 1.00 34.56 C ATOM 7025 CG LYS A 461 −33.717 28.986 20.750 1.00 35.84 C ATOM 7028 CD LYS A 461 −32.519 29.859 20.347 1.00 37.64 C ATOM 7031 CE LYS A 461 −32.232 29.804 18.838 1.00 38.44 C ATOM 7034 NZ LYS A 461 −33.141 30.671 18.027 1.00 38.31 N ATOM 7038 C LYS A 461 −32.974 28.476 24.544 1.00 33.73 C ATOM 7039 O LYS A 461 −32.994 29.626 24.983 1.00 33.23 O ATOM 7041 N GLY A 462 −33.078 27.395 25.321 1.00 33.48 N ATOM 7042 CA GLY A 462 −33.173 27.464 26.784 1.00 33.23 C ATOM 7045 C GLY A 462 −34.332 28.320 27.239 1.00 32.95 C ATOM 7046 O GLY A 462 −34.144 29.258 28.004 1.00 33.17 O ATOM 7048 N ILE A 463 −35.528 28.000 26.757 1.00 32.52 N ATOM 7049 CA ILE A 463 −36.694 28.843 26.971 1.00 32.32 C ATOM 7051 CB ILE A 463 −37.006 29.724 25.734 1.00 32.47 C ATOM 7053 CG1 ILE A 463 −37.152 28.866 24.463 1.00 32.41 C ATOM 7056 CD1 ILE A 463 −37.359 29.675 23.191 1.00 32.02 C ATOM 7060 CG2 ILE A 463 −35.937 30.810 25.571 1.00 32.44 C ATOM 7064 C ILE A 463 −37.902 28.006 27.309 1.00 32.15 C ATOM 7065 O ILE A 463 −37.886 26.799 27.145 1.00 32.01 O ATOM 7067 N SER A 464 −38.950 28.670 27.780 1.00 32.27 N ATOM 7068 CA SER A 464 −40.163 28.006 28.239 1.00 32.52 C ATOM 7070 CB SER A 464 −40.964 28.974 29.110 1.00 32.65 C ATOM 7073 OG SER A 464 −41.112 30.224 28.457 1.00 32.69 O ATOM 7075 C SER A 464 −41.036 27.522 27.079 1.00 32.53 C ATOM 7076 O SER A 464 −40.968 28.069 25.986 1.00 32.62 O ATOM 7078 N GLU A 465 −41.857 26.500 27.332 1.00 32.47 N ATOM 7079 CA GLU A 465 −42.836 26.010 26.353 1.00 32.33 C ATOM 7081 CB GLU A 465 −43.689 24.868 26.935 1.00 32.34 C ATOM 7084 CG GLU A 465 −44.756 24.312 25.974 1.00 32.37 C ATOM 7087 CD GLU A 465 −45.675 23.279 26.611 1.00 32.47 C ATOM 7088 OE1 GLU A 465 −45.297 22.659 27.630 1.00 31.63 O ATOM 7089 OE2 GLU A 465 −46.785 23.086 26.074 1.00 32.77 O ATOM 7090 C GLU A 465 −43.758 27.124 25.864 1.00 32.33 C ATOM 7091 O GLU A 465 −44.078 27.183 24.676 1.00 32.60 O ATOM 7093 N GLU A 466 −44.196 28.001 26.767 1.00 32.08 N ATOM 7094 CA GLU A 466 −45.085 29.097 26.380 1.00 31.79 C ATOM 7096 CB GLU A 466 −45.606 29.832 27.624 1.00 31.91 C ATOM 7099 CG GLU A 466 −46.503 31.041 27.304 1.00 32.82 C ATOM 7102 CD GLU A 466 −47.426 31.472 28.452 1.00 33.67 C ATOM 7103 OE1 GLU A 466 −47.519 30.756 29.478 1.00 35.09 O ATOM 7104 OE2 GLU A 466 −48.077 32.533 28.312 1.00 33.12 O ATOM 7105 C GLU A 466 −44.392 30.052 25.386 1.00 31.13 C ATOM 7106 O GLU A 466 −45.032 30.603 24.492 1.00 30.87 O ATOM 7108 N LEU A 467 −43.077 30.194 25.531 1.00 30.57 N ATOM 7109 CA LEU A 467 −42.265 31.102 24.708 1.00 30.18 C ATOM 7111 CB LEU A 467 −41.055 31.604 25.524 1.00 30.38 C ATOM 7114 CG LEU A 467 −40.674 33.087 25.463 1.00 30.39 C ATOM 7116 CD1 LEU A 467 −41.608 33.900 26.362 1.00 30.23 C ATOM 7120 CD2 LEU A 467 −39.214 33.308 25.872 1.00 30.31 C ATOM 7124 C LEU A 467 −41.773 30.401 23.439 1.00 29.47 C ATOM 7125 O LEU A 467 −41.660 31.010 22.382 1.00 29.17 O ATOM 7127 N ALA A 468 −41.445 29.121 23.562 1.00 28.93 N ATOM 7128 CA ALA A 468 −41.095 28.310 22.404 1.00 28.45 C ATOM 7130 CB ALA A 468 −40.613 26.935 22.830 1.00 28.10 C ATOM 7134 C ALA A 468 −42.306 28.193 21.494 1.00 28.08 C ATOM 7135 O ALA A 468 −42.179 28.321 20.285 1.00 28.24 O ATOM 7137 N THR A 469 −43.479 27.964 22.080 1.00 27.58 N ATOM 7138 CA THR A 469 −44.719 27.870 21.322 1.00 27.26 C ATOM 7140 CB THR A 469 −45.928 27.710 22.261 1.00 27.28 C ATOM 7142 OG1 THR A 469 −46.063 26.330 22.627 1.00 27.55 O ATOM 7144 CG2 THR A 469 −47.222 28.185 21.597 1.00 27.34 C ATOM 7148 C THR A 469 −44.916 29.099 20.449 1.00 27.10 C ATOM 7149 O THR A 469 −45.176 28.989 19.250 1.00 27.11 O ATOM 7151 N GLU A 470 −44.774 30.267 21.061 1.00 26.88 N ATOM 7152 CA GLU A 470 −44.944 31.542 20.376 1.00 26.84 C ATOM 7154 CB GLU A 470 −44.832 32.663 21.400 1.00 27.07 C ATOM 7157 CG GLU A 470 −45.357 34.003 20.958 1.00 28.47 C ATOM 7160 CD GLU A 470 −45.140 35.087 22.008 1.00 30.51 C ATOM 7161 OE1 GLU A 470 −45.029 34.775 23.221 1.00 31.53 O ATOM 7162 OE2 GLU A 470 −45.083 36.269 21.608 1.00 32.59 O ATOM 7163 C GLU A 470 −43.926 31.750 19.239 1.00 26.48 C ATOM 7164 O GLU A 470 −44.261 32.296 18.184 1.00 26.29 O ATOM 7166 N SER A 471 −42.686 31.316 19.452 1.00 26.12 N ATOM 7167 CA SER A 471 −41.660 31.386 18.408 1.00 25.85 C ATOM 7169 CB SER A 471 −40.296 30.933 18.941 1.00 25.96 C ATOM 7172 OG SER A 471 −39.656 31.939 19.711 1.00 26.53 O ATOM 7174 C SER A 471 −42.036 30.529 17.208 1.00 25.35 C ATOM 7175 O SER A 471 −41.761 30.899 16.067 1.00 25.43 O ATOM 7177 N VAL A 472 −42.653 29.381 17.482 1.00 24.95 N ATOM 7178 CA VAL A 472 −43.097 28.451 16.438 1.00 24.65 C ATOM 7180 CB VAL A 472 −43.485 27.055 17.024 1.00 24.57 C ATOM 7182 CG1 VAL A 472 −44.257 26.222 16.016 1.00 23.23 C ATOM 7186 CG2 VAL A 472 −42.232 26.309 17.494 1.00 23.83 C ATOM 7190 C VAL A 472 −44.252 29.039 15.631 1.00 24.71 C ATOM 7191 O VAL A 472 −44.369 28.776 14.440 1.00 24.63 O ATOM 7193 N MET A 473 −45.073 29.866 16.269 1.00 24.79 N ATOM 7194 CA MET A 473 −46.143 30.591 15.565 1.00 24.94 C ATOM 7196 CB MET A 473 −47.059 31.266 16.576 1.00 25.11 C ATOM 7199 CG MET A 473 −47.683 30.335 17.560 1.00 25.11 C ATOM 7202 SD MET A 473 −48.967 29.391 16.780 1.00 25.35 S ATOM 7203 CE MET A 473 −50.064 29.163 18.189 1.00 26.11 C ATOM 7207 C MET A 473 −45.613 31.672 14.605 1.00 24.86 C ATOM 7208 O MET A 473 −46.132 31.849 13.513 1.00 24.57 O ATOM 7210 N ASN A 474 −44.589 32.405 15.032 1.00 24.89 N ATOM 7211 CA ASN A 474 −43.951 33.383 14.166 1.00 25.00 C ATOM 7213 CB ASN A 474 −43.009 34.278 14.966 1.00 25.12 C ATOM 7216 CG ASN A 474 −43.700 34.966 16.127 1.00 25.77 C ATOM 7217 OD1 ASN A 474 −43.058 35.312 17.114 1.00 26.96 O ATOM 7218 ND2 ASN A 474 −45.015 35.163 16.021 1.00 26.31 N ATOM 7221 C ASN A 474 −43.195 32.707 13.024 1.00 24.84 C ATOM 7222 O ASN A 474 −42.979 33.313 11.973 1.00 25.07 O ATOM 7224 N LEU A 475 −42.792 31.455 13.227 1.00 24.46 N ATOM 7225 CA LEU A 475 −42.218 30.671 12.142 1.00 24.06 C ATOM 7227 CB LEU A 475 −41.596 29.367 12.653 1.00 24.27 C ATOM 7230 CG LEU A 475 −40.307 29.072 11.886 1.00 25.08 C ATOM 7232 CD1 LEU A 475 −39.207 30.000 12.419 1.00 25.89 C ATOM 7236 CD2 LEU A 475 −39.887 27.622 11.985 1.00 25.33 C ATOM 7240 C LEU A 475 −43.278 30.365 11.085 1.00 23.26 C ATOM 7241 O LEU A 475 −43.018 30.479 9.884 1.00 22.90 O ATOM 7243 N ILE A 476 −44.471 29.978 11.534 1.00 22.53 N ATOM 7244 CA ILE A 476 −45.544 29.632 10.606 1.00 21.93 C ATOM 7246 CB ILE A 476 −46.773 29.017 11.308 1.00 21.58 C ATOM 7248 CG1 ILE A 476 −46.499 27.550 11.664 1.00 21.32 C ATOM 7251 CD1 ILE A 476 −47.552 26.902 12.598 1.00 20.33 C ATOM 7255 CG2 ILE A 476 −47.994 29.104 10.428 1.00 20.46 C ATOM 7259 C ILE A 476 −45.926 30.887 9.853 1.00 22.07 C ATOM 7260 O ILE A 476 −46.007 30.869 8.626 1.00 22.47 O ATOM 7262 N ASP A 477 −46.122 31.982 10.584 1.00 21.81 N ATOM 7263 CA ASP A 477 −46.483 33.245 9.970 1.00 21.56 C ATOM 7265 CB ASP A 477 −46.643 34.337 11.032 1.00 21.89 C ATOM 7268 CG ASP A 477 −47.962 34.217 11.817 1.00 23.39 C ATOM 7269 OD1 ASP A 477 −48.854 33.441 11.375 1.00 24.41 O ATOM 7270 OD2 ASP A 477 −48.103 34.902 12.875 1.00 23.80 O ATOM 7271 C ASP A 477 −45.425 33.626 8.947 1.00 21.06 C ATOM 7272 O ASP A 477 −45.759 33.913 7.795 1.00 20.78 O ATOM 7274 N GLU A 478 −44.156 33.591 9.361 1.00 20.63 N ATOM 7275 CA GLU A 478 −43.027 33.919 8.467 1.00 20.45 C ATOM 7277 CB GLU A 478 −41.680 33.793 9.200 1.00 20.66 C ATOM 7280 CG GLU A 478 −40.422 34.044 8.339 1.00 22.27 C ATOM 7283 CD GLU A 478 −39.107 33.579 9.018 1.00 24.72 C ATOM 7284 OE1 GLU A 478 −38.553 34.367 9.817 1.00 26.19 O ATOM 7285 OE2 GLU A 478 −38.619 32.442 8.745 1.00 25.66 O ATOM 7286 C GLU A 478 −43.041 33.042 7.217 1.00 19.54 C ATOM 7287 O GLU A 478 −42.879 33.544 6.102 1.00 19.02 O ATOM 7289 N THR A 479 −43.250 31.743 7.413 1.00 18.76 N ATOM 7290 CA THR A 479 −43.358 30.808 6.294 1.00 18.45 C ATOM 7292 CB THR A 479 −43.503 29.339 6.774 1.00 18.26 C ATOM 7294 OG1 THR A 479 −42.334 28.955 7.494 1.00 17.30 O ATOM 7296 CG2 THR A 479 −43.669 28.394 5.592 1.00 17.93 C ATOM 7300 C THR A 479 −44.504 31.173 5.314 1.00 18.39 C ATOM 7301 O THR A 479 −44.280 31.200 4.103 1.00 18.58 O ATOM 7303 N TRP A 480 −45.709 31.457 5.818 1.00 17.85 N ATOM 7304 CA TRP A 480 −46.801 31.909 4.942 1.00 17.44 C ATOM 7306 CB TRP A 480 −48.086 32.225 5.728 1.00 17.67 C ATOM 7309 CG TRP A 480 −48.969 31.042 5.888 1.00 17.09 C ATOM 7310 CD1 TRP A 480 −48.996 30.195 6.936 1.00 16.76 C ATOM 7312 NE1 TRP A 480 −49.914 29.216 6.724 1.00 17.08 N ATOM 7314 CE2 TRP A 480 −50.501 29.410 5.507 1.00 17.86 C ATOM 7315 CD2 TRP A 480 −49.930 30.559 4.954 1.00 17.15 C ATOM 7316 CE3 TRP A 480 −50.356 30.980 3.696 1.00 18.31 C ATOM 7318 CZ3 TRP A 480 −51.337 30.244 3.039 1.00 19.10 C ATOM 7320 CH2 TRP A 480 −51.897 29.107 3.622 1.00 18.83 C ATOM 7322 CZ2 TRP A 480 −51.493 28.673 4.855 1.00 18.86 C ATOM 7324 C TRP A 480 −46.426 33.124 4.097 1.00 17.10 C ATOM 7325 O TRP A 480 −46.824 33.215 2.943 1.00 17.22 O ATOM 7327 N LYS A 481 −45.675 34.062 4.659 1.00 16.60 N ATOM 7328 CA LYS A 481 −45.275 35.215 3.886 1.00 16.23 C ATOM 7330 CB LYS A 481 −44.566 36.243 4.747 1.00 16.42 C ATOM 7333 CG LYS A 481 −45.417 36.954 5.769 1.00 16.42 C ATOM 7336 CD LYS A 481 −44.555 37.979 6.505 1.00 16.40 C ATOM 7339 CE LYS A 481 −45.199 38.504 7.782 1.00 16.66 C ATOM 7342 NZ LYS A 481 −44.184 38.717 8.846 1.00 16.72 N ATOM 7346 C LYS A 481 −44.357 34.782 2.767 1.00 15.94 C ATOM 7347 O LYS A 481 −44.451 35.291 1.674 1.00 16.09 O ATOM 7349 N LYS A 482 −43.461 33.849 3.034 1.00 15.98 N ATOM 7350 CA LYS A 482 −42.559 33.369 1.996 1.00 16.30 C ATOM 7352 CB LYS A 482 −41.409 32.563 2.594 1.00 16.51 C ATOM 7355 CG LYS A 482 −40.354 33.445 3.286 1.00 17.46 C ATOM 7358 CD LYS A 482 −39.486 32.647 4.241 1.00 18.48 C ATOM 7361 CE LYS A 482 −38.625 33.548 5.096 1.00 18.94 C ATOM 7364 NZ LYS A 482 −37.865 32.773 6.129 1.00 20.40 N ATOM 7368 C LYS A 482 −43.296 32.561 .938 1.00 16.40 C ATOM 7369 O LYS A 482 −42.941 32.614 −.229 1.00 16.85 O ATOM 7371 N MET A 483 −44.328 31.824 1.332 1.00 16.57 N ATOM 7372 CA MET A 483 −45.149 31.100 .366 1.00 16.67 C ATOM 7374 CB MET A 483 −46.128 30.156 1.057 1.00 16.55 C ATOM 7377 CG MET A 483 −45.496 28.923 1.675 1.00 16.50 C ATOM 7380 SD MET A 483 −46.715 27.684 2.194 1.00 17.39 S ATOM 7381 CE MET A 483 −47.937 28.704 3.025 1.00 17.27 C ATOM 7385 C MET A 483 −45.928 32.069 −.495 1.00 17.06 C ATOM 7386 O MET A 483 −46.027 31.867 −1.688 1.00 17.17 O ATOM 7388 N ASN A 484 −46.483 33.110 .118 1.00 17.72 N ATOM 7389 CA ASN A 484 −47.305 34.093 −.587 1.00 18.35 C ATOM 7391 CB ASN A 484 −47.861 35.129 .397 1.00 18.26 C ATOM 7394 CG ASN A 484 −48.994 34.601 1.248 1.00 17.35 C ATOM 7395 OD1 ASN A 484 −49.597 33.577 .934 1.00 17.54 O ATOM 7396 ND2 ASN A 484 −49.304 35.317 2.331 1.00 14.10 N ATOM 7399 C ASN A 484 −46.541 34.839 −1.677 1.00 19.51 C ATOM 7400 O ASN A 484 −47.123 35.250 −2.685 1.00 19.49 O ATOM 7402 N LYS A 485 −45.243 35.035 −1.463 1.00 20.86 N ATOM 7403 CA LYS A 485 −44.394 35.681 −2.456 1.00 22.12 C ATOM 7405 CB LYS A 485 −43.070 36.092 −1.823 1.00 22.08 C ATOM 7408 CG LYS A 485 −42.229 37.060 −2.641 1.00 23.09 C ATOM 7411 CD LYS A 485 −40.783 37.072 −2.109 1.00 25.38 C ATOM 7414 CE LYS A 485 −40.098 38.460 −2.135 1.00 26.12 C ATOM 7417 NZ LYS A 485 −38.943 38.555 −3.086 1.00 26.61 N ATOM 7421 C LYS A 485 −44.164 34.743 −3.656 1.00 23.36 C ATOM 7422 O LYS A 485 −44.120 35.191 −4.802 1.00 23.00 O ATOM 7424 N GLU A 486 −44.027 33.442 −3.400 1.00 24.99 N ATOM 7425 CA GLU A 486 −43.902 32.479 −4.491 1.00 26.35 C ATOM 7427 CB GLU A 486 −43.627 31.061 −3.978 1.00 26.55 C ATOM 7430 CG GLU A 486 −42.985 30.130 −5.033 1.00 28.29 C ATOM 7433 CD GLU A 486 −41.466 30.324 −5.191 1.00 31.11 C ATOM 7434 OE1 GLU A 486 −40.981 30.466 −6.341 1.00 32.07 O ATOM 7435 OE2 GLU A 486 −40.744 30.335 −4.159 1.00 33.04 O ATOM 7436 C GLU A 486 −45.157 32.501 −5.362 1.00 27.13 C ATOM 7437 O GLU A 486 −45.064 32.618 −6.583 1.00 27.57 O ATOM 7439 N LYS A 487 −46.325 32.422 −4.739 1.00 28.12 N ATOM 7440 CA LYS A 487 −47.582 32.378 −5.485 1.00 29.12 C ATOM 7442 CB LYS A 487 −48.788 32.260 −4.542 1.00 29.21 C ATOM 7445 CG LYS A 487 −50.167 32.296 −5.235 1.00 28.57 C ATOM 7448 CD LYS A 487 −50.403 31.040 −6.036 1.00 27.91 C ATOM 7451 CE LYS A 487 −51.615 31.141 −6.936 1.00 28.38 C ATOM 7454 NZ LYS A 487 −52.874 31.460 −6.211 1.00 28.03 N ATOM 7458 C LYS A 487 −47.756 33.603 −6.352 1.00 30.18 C ATOM 7459 O LYS A 487 −48.308 33.514 −7.446 1.00 30.21 O ATOM 7461 N LEU A 488 −47.295 34.743 −5.844 1.00 31.64 N ATOM 7462 CA LEU A 488 −47.422 36.026 −6.532 1.00 32.65 C ATOM 7464 CB LEU A 488 −47.426 37.144 −5.494 1.00 32.43 C ATOM 7467 CG LEU A 488 −48.091 38.446 −5.907 1.00 32.50 C ATOM 7469 CD1 LEU A 488 −49.593 38.288 −5.943 1.00 32.66 C ATOM 7473 CD2 LEU A 488 −47.707 39.554 −4.943 1.00 33.38 C ATOM 7477 C LEU A 488 −46.286 36.242 −7.542 1.00 33.99 C ATOM 7478 O LEU A 488 −46.536 36.539 −8.705 1.00 33.72 O ATOM 7480 N GLY A 489 −45.046 36.045 −7.091 1.00 35.85 N ATOM 7481 CA GLY A 489 −43.845 36.361 −7.874 1.00 37.37 C ATOM 7484 C GLY A 489 −43.278 35.221 −8.709 1.00 38.76 C ATOM 7485 O GLY A 489 −42.414 34.467 −8.250 1.00 39.06 O ATOM 7487 N GLY A 490 −43.760 35.119 −9.947 1.00 40.26 N ATOM 7488 CA GLY A 490 −43.285 34.130 −10.927 1.00 41.03 C ATOM 7491 C GLY A 490 −42.193 33.194 −10.436 1.00 41.61 C ATOM 7492 O GLY A 490 −41.010 33.547 −10.423 1.00 41.62 O ATOM 7494 N SER A 491 −42.590 31.996 −10.023 1.00 42.17 N ATOM 7495 CA SER A 491 −41.619 30.962 −9.662 1.00 42.54 C ATOM 7497 CB SER A 491 −42.279 29.909 −8.741 1.00 42.63 C ATOM 7500 OG SER A 491 −43.451 29.345 −9.294 1.00 42.44 O ATOM 7502 C SER A 491 −41.032 30.349 −10.952 1.00 42.50 C ATOM 7503 O SER A 491 −41.117 30.961 −12.030 1.00 42.57 O ATOM 7505 N LEU A 492 −40.405 29.177 −10.843 1.00 42.18 N ATOM 7506 CA LEU A 492 −40.185 28.333 −12.021 1.00 41.96 C ATOM 7508 CB LEU A 492 −39.110 27.270 −11.782 1.00 42.39 C ATOM 7511 CG LEU A 492 −37.695 27.671 −11.353 1.00 44.21 C ATOM 7513 CD1 LEU A 492 −36.783 26.438 −11.498 1.00 45.26 C ATOM 7517 CD2 LEU A 492 −37.120 28.896 −12.129 1.00 45.51 C ATOM 7521 C LEU A 492 −41.479 27.610 −12.356 1.00 40.88 C ATOM 7522 O LEU A 492 −41.713 27.244 −13.504 1.00 40.78 O ATOM 7524 N PHE A 493 −42.308 27.409 −11.339 1.00 39.61 N ATOM 7525 CA PHE A 493 −43.500 26.595 −11.460 1.00 38.85 C ATOM 7527 CB PHE A 493 −43.783 25.911 −10.124 1.00 38.62 C ATOM 7530 CG PHE A 493 −42.725 24.937 −9.713 1.00 37.16 C ATOM 7531 CD1 PHE A 493 −42.901 23.587 −9.916 1.00 35.26 C ATOM 7533 CE1 PHE A 493 −41.934 22.698 −9.546 1.00 34.86 C ATOM 7535 CZ PHE A 493 −40.769 23.143 −8.966 1.00 35.09 C ATOM 7537 CE2 PHE A 493 −40.574 24.482 −8.759 1.00 35.45 C ATOM 7539 CD2 PHE A 493 −41.549 25.374 −9.130 1.00 36.36 C ATOM 7541 C PHE A 493 −44.714 27.412 −11.890 1.00 38.62 C ATOM 7542 O PHE A 493 −44.756 28.621 −11.702 1.00 38.86 O ATOM 7544 N ALA A 494 −45.698 26.731 −12.469 1.00 38.32 N ATOM 7545 CA ALA A 494 −46.977 27.337 −12.843 1.00 38.09 C ATOM 7547 CB ALA A 494 −47.658 26.486 −13.906 1.00 38.17 C ATOM 7551 C ALA A 494 −47.891 27.479 −11.623 1.00 37.76 C ATOM 7552 O ALA A 494 −48.039 26.541 −10.845 1.00 38.15 O ATOM 7554 N LYS A 495 −48.541 28.629 −11.484 1.00 37.15 N ATOM 7555 CA LYS A 495 −49.321 28.947 −10.270 1.00 36.53 C ATOM 7557 CB LYS A 495 −50.116 30.258 −10.477 1.00 36.90 C ATOM 7560 CG LYS A 495 −49.235 31.524 −10.582 1.00 37.72 C ATOM 7563 CD LYS A 495 −50.061 32.826 −10.585 1.00 38.87 C ATOM 7566 CE LYS A 495 −49.140 34.065 −10.665 1.00 39.78 C ATOM 7569 NZ LYS A 495 −49.786 35.369 −10.282 1.00 39.78 N ATOM 7573 C LYS A 495 −50.238 27.809 −9.724 1.00 35.25 C ATOM 7574 O LYS A 495 −50.261 27.563 −8.523 1.00 34.91 O ATOM 7576 N PRO A 496 −50.978 27.107 −10.599 1.00 33.76 N ATOM 7577 CA PRO A 496 −51.846 26.015 −10.162 1.00 32.74 C ATOM 7579 CB PRO A 496 −52.222 25.340 −11.474 1.00 32.99 C ATOM 7582 CG PRO A 496 −52.337 26.470 −12.385 1.00 33.75 C ATOM 7585 CD PRO A 496 −51.196 27.400 −12.022 1.00 33.83 C ATOM 7588 C PRO A 496 −51.194 24.998 −9.267 1.00 31.24 C ATOM 7589 O PRO A 496 −51.822 24.522 −8.331 1.00 31.54 O ATOM 7590 N PHE A 497 −49.954 24.642 −9.566 1.00 29.40 N ATOM 7591 CA PHE A 497 −49.229 23.726 −8.708 1.00 27.76 C ATOM 7593 CB PHE A 497 −48.162 22.948 −9.474 1.00 27.62 C ATOM 7596 CG PHE A 497 −47.351 22.040 −8.597 1.00 26.33 C ATOM 7597 CD1 PHE A 497 −47.944 20.969 −7.974 1.00 24.96 C ATOM 7599 CE1 PHE A 497 −47.218 20.151 −7.156 1.00 25.04 C ATOM 7601 CZ PHE A 497 −45.875 20.396 −6.940 1.00 24.79 C ATOM 7603 CE2 PHE A 497 −45.274 21.457 −7.549 1.00 24.73 C ATOM 7605 CD2 PHE A 497 −46.010 22.282 −8.366 1.00 25.48 C ATOM 7607 C PHE A 497 −48.592 24.407 −7.494 1.00 26.59 C ATOM 7608 O PHE A 497 −48.361 23.738 −6.500 1.00 26.77 O ATOM 7610 N VAL A 498 −48.291 25.704 −7.535 1.00 24.83 N ATOM 7611 CA VAL A 498 −47.869 26.338 −6.289 1.00 23.86 C ATOM 7613 CB VAL A 498 −47.181 27.722 −6.455 1.00 23.47 C ATOM 7615 CG1 VAL A 498 −48.163 28.755 −6.759 1.00 24.57 C ATOM 7619 CG2 VAL A 498 −46.151 27.690 −7.551 1.00 23.54 C ATOM 7623 C VAL A 498 −49.094 26.396 −5.355 1.00 22.97 C ATOM 7624 O VAL A 498 −48.978 26.130 −4.161 1.00 23.39 O ATOM 7626 N GLU A 499 −50.268 26.687 −5.903 1.00 21.68 N ATOM 7627 CA GLU A 499 −51.473 26.719 −5.106 1.00 20.84 C ATOM 7629 CB GLU A 499 −52.677 27.136 −5.930 1.00 20.99 C ATOM 7632 CG GLU A 499 −53.957 27.352 −5.099 1.00 21.25 C ATOM 7635 CD GLU A 499 −53.930 28.630 −4.265 1.00 21.77 C ATOM 7636 OE1 GLU A 499 −52.982 29.448 −4.383 1.00 20.74 O ATOM 7637 OE2 GLU A 499 −54.876 28.812 −3.476 1.00 22.76 O ATOM 7638 C GLU A 499 −51.766 25.371 −4.497 1.00 20.35 C ATOM 7639 O GLU A 499 −52.137 25.308 −3.318 1.00 20.78 O ATOM 7641 N THR A 500 −51.629 24.286 −5.264 1.00 19.40 N ATOM 7642 CA THR A 500 −51.894 22.970 −4.667 1.00 18.94 C ATOM 7644 CB THR A 500 −51.993 21.782 −5.683 1.00 18.96 C ATOM 7646 OG1 THR A 500 −50.708 21.475 −6.202 1.00 19.44 O ATOM 7648 CG2 THR A 500 −52.991 22.071 −6.835 1.00 18.75 C ATOM 7652 C THR A 500 −50.895 22.674 −3.526 1.00 18.20 C ATOM 7653 O THR A 500 −51.280 22.100 −2.519 1.00 17.68 O ATOM 7655 N ALA A 501 −49.646 23.119 −3.666 1.00 17.49 N ATOM 7656 CA ALA A 501 −48.663 23.021 −2.593 1.00 17.18 C ATOM 7658 CB ALA A 501 −47.348 23.563 −3.051 1.00 16.98 C ATOM 7662 C ALA A 501 −49.120 23.770 −1.338 1.00 17.38 C ATOM 7663 O ALA A 501 −49.098 23.219 −.230 1.00 17.45 O ATOM 7665 N ILE A 502 −49.517 25.031 −1.508 1.00 17.29 N ATOM 7666 CA ILE A 502 −49.971 25.857 −.386 1.00 17.07 C ATOM 7668 CB ILE A 502 −50.353 27.304 −.846 1.00 17.09 C ATOM 7670 CG1 ILE A 502 −49.092 28.069 −1.286 1.00 17.17 C ATOM 7673 CD1 ILE A 502 −49.345 29.345 −2.116 1.00 16.25 C ATOM 7677 CG2 ILE A 502 −51.110 28.076 .265 1.00 16.14 C ATOM 7681 C ILE A 502 −51.155 25.168 .285 1.00 17.24 C ATOM 7682 O ILE A 502 −51.265 25.163 1.516 1.00 17.03 O ATOM 7684 N ASN A 503 −52.022 24.559 −.522 1.00 17.32 N ATOM 7685 CA ASN A 503 −53.167 23.823 .022 1.00 17.75 C ATOM 7687 CB ASN A 503 −53.986 23.221 −1.121 1.00 17.70 C ATOM 7690 CG ASN A 503 −54.760 24.261 −1.888 1.00 18.41 C ATOM 7691 OD1 ASN A 503 −55.058 25.334 −1.382 1.00 18.94 O ATOM 7692 ND2 ASN A 503 −55.107 23.939 −3.119 1.00 20.42 N ATOM 7695 C ASN A 503 −52.803 22.727 1.075 1.00 17.74 C ATOM 7696 O ASN A 503 −53.619 22.387 1.949 1.00 17.96 O ATOM 7698 N LEU A 504 −51.589 22.185 .993 1.00 17.23 N ATOM 7699 CA LEU A 504 −51.105 21.249 1.994 1.00 17.10 C ATOM 7701 CB LEU A 504 −49.745 20.686 1.583 1.00 17.28 C ATOM 7704 CG LEU A 504 −49.213 19.528 2.426 1.00 17.29 C ATOM 7706 CD1 LEU A 504 −49.570 18.196 1.762 1.00 17.22 C ATOM 7710 CD2 LEU A 504 −47.708 19.686 2.616 1.00 16.83 C ATOM 7714 C LEU A 504 −50.971 21.939 3.347 1.00 16.97 C ATOM 7715 O LEU A 504 −51.237 21.330 4.379 1.00 16.84 O ATOM 7717 N ALA A 505 −50.535 23.201 3.330 1.00 16.90 N ATOM 7718 CA ALA A 505 −50.433 24.015 4.540 1.00 16.68 C ATOM 7720 CB ALA A 505 −49.739 25.309 4.243 1.00 16.54 C ATOM 7724 C ALA A 505 −51.826 24.281 5.074 1.00 16.77 C ATOM 7725 O ALA A 505 −52.087 24.123 6.266 1.00 16.80 O ATOM 7727 N ARG A 506 −52.726 24.664 4.172 1.00 16.82 N ATOM 7728 CA ARG A 506 −54.128 24.875 4.521 1.00 16.84 C ATOM 7730 CB ARG A 506 −54.944 25.274 3.286 1.00 16.86 C ATOM 7733 CG ARG A 506 −54.649 26.661 2.795 1.00 16.27 C ATOM 7736 CD ARG A 506 −55.586 27.090 1.726 1.00 15.26 C ATOM 7739 NE ARG A 506 −55.240 28.436 1.273 1.00 15.31 N ATOM 7741 CZ ARG A 506 −54.744 28.758 .082 1.00 14.28 C ATOM 7742 NH1 ARG A 506 −54.519 27.856 −.856 1.00 14.12 N ATOM 7745 NH2 ARG A 506 −54.471 30.018 −.176 1.00 15.94 N ATOM 7748 C ARG A 506 −54.732 23.631 5.122 1.00 16.96 C ATOM 7749 O ARG A 506 −55.480 23.707 6.089 1.00 16.71 O ATOM 7751 N GLN A 507 −54.415 22.481 4.542 1.00 17.37 N ATOM 7752 CA GLN A 507 −54.962 21.233 5.048 1.00 17.87 C ATOM 7754 CB GLN A 507 −54.712 20.075 4.087 1.00 17.80 C ATOM 7757 CG GLN A 507 −55.293 18.740 4.571 1.00 17.24 C ATOM 7760 CD GLN A 507 −56.777 18.805 4.860 1.00 16.23 C ATOM 7761 OE1 GLN A 507 −57.506 19.585 4.250 1.00 16.66 O ATOM 7762 NE2 GLN A 507 −57.233 17.980 5.790 1.00 14.96 N ATOM 7765 C GLN A 507 −54.401 20.890 6.423 1.00 18.28 C ATOM 7766 O GLN A 507 −55.148 20.419 7.287 1.00 18.53 O ATOM 7768 N SER A 508 −53.096 21.113 6.609 1.00 18.50 N ATOM 7769 CA SER A 508 −52.435 20.924 7.908 1.00 18.54 C ATOM 7771 CB SER A 508 −50.979 21.385 7.856 1.00 18.40 C ATOM 7774 OG SER A 508 −50.259 20.694 6.857 1.00 18.51 O ATOM 7776 C SER A 508 −53.147 21.752 8.942 1.00 18.78 C ATOM 7777 O SER A 508 −53.535 21.278 10.006 1.00 18.33 O ATOM 7779 N HIS A 509 −53.324 23.014 8.599 1.00 19.37 N ATOM 7780 CA HIS A 509 −54.014 23.922 9.466 1.00 19.92 C ATOM 7782 CB HIS A 509 −54.126 25.295 8.818 1.00 20.07 C ATOM 7785 CG HIS A 509 −53.000 26.188 9.174 1.00 19.82 C ATOM 7786 ND1 HIS A 509 −52.079 26.631 8.255 1.00 19.73 N ATOM 7788 CE1 HIS A 509 −51.187 27.383 8.866 1.00 20.25 C ATOM 7790 NE2 HIS A 509 −51.485 27.426 10.149 1.00 21.66 N ATOM 7792 CD2 HIS A 509 −52.615 26.682 10.368 1.00 20.98 C ATOM 7794 C HIS A 509 −55.389 23.448 9.839 1.00 20.41 C ATOM 7795 O HIS A 509 −55.821 23.694 10.934 1.00 20.22 O ATOM 7797 N CYS A 510 −56.093 22.808 8.918 1.00 21.33 N ATOM 7798 CA CYS A 510 −57.470 22.396 9.189 1.00 22.03 C ATOM 7800 CB CYS A 510 −58.278 22.383 7.894 1.00 21.90 C ATOM 7803 SG CYS A 510 −58.522 24.055 7.270 1.00 21.93 S ATOM 7805 C CYS A 510 −57.527 21.054 9.908 1.00 22.60 C ATOM 7806 O CYS A 510 −58.423 20.822 10.706 1.00 22.23 O ATOM 7808 N THR A 511 −56.553 20.194 9.627 1.00 23.67 N ATOM 7809 CA THR A 511 −56.421 18.920 10.305 1.00 24.81 C ATOM 7811 CB THR A 511 −55.437 18.000 9.565 1.00 24.70 C ATOM 7813 OG1 THR A 511 −56.071 17.485 8.394 1.00 24.45 O ATOM 7815 CG2 THR A 511 −55.003 16.844 10.448 1.00 24.23 C ATOM 7819 C THR A 511 −55.965 19.086 11.756 1.00 26.22 C ATOM 7820 O THR A 511 −56.685 18.717 12.679 1.00 26.12 O ATOM 7822 N TYR A 512 −54.775 19.643 11.959 1.00 28.08 N ATOM 7823 CA TYR A 512 −54.177 19.657 13.298 1.00 29.63 C ATOM 7825 CB TYR A 512 −52.663 19.783 13.238 1.00 29.67 C ATOM 7828 CG TYR A 512 −52.117 18.579 12.560 1.00 29.56 C ATOM 7829 CD1 TYR A 512 −51.965 17.395 13.246 1.00 29.66 C ATOM 7831 CE1 TYR A 512 −51.507 16.273 12.614 1.00 30.94 C ATOM 7833 CZ TYR A 512 −51.217 16.326 11.263 1.00 32.04 C ATOM 7834 OH TYR A 512 −50.757 15.209 10.608 1.00 33.78 O ATOM 7836 CE2 TYR A 512 −51.390 17.492 10.557 1.00 31.29 C ATOM 7838 CD2 TYR A 512 −51.847 18.600 11.205 1.00 30.53 C ATOM 7840 C TYR A 512 −54.812 20.676 14.206 1.00 31.11 C ATOM 7841 O TYR A 512 −55.494 20.277 15.139 1.00 31.34 O ATOM 7843 N HIS A 513 −54.583 21.969 13.966 1.00 32.89 N ATOM 7844 CA HIS A 513 −55.505 23.023 14.442 1.00 34.48 C ATOM 7846 CB HIS A 513 −56.372 23.461 13.225 1.00 35.13 C ATOM 7849 CG HIS A 513 −57.704 24.108 13.529 1.00 37.10 C ATOM 7850 ND1 HIS A 513 −58.265 25.040 12.678 1.00 38.69 N ATOM 7852 CE1 HIS A 513 −59.442 25.416 13.151 1.00 39.23 C ATOM 7854 NE2 HIS A 513 −59.678 24.751 14.268 1.00 38.18 N ATOM 7856 CD2 HIS A 513 −58.615 23.915 14.519 1.00 38.17 C ATOM 7858 C HIS A 513 −56.337 22.503 15.610 1.00 35.00 C ATOM 7859 O HIS A 513 −56.302 23.074 16.712 1.00 35.48 O ATOM 7861 N ASN A 514 −57.079 21.419 15.351 1.00 35.23 N ATOM 7862 CA ASN A 514 −57.934 20.768 16.347 1.00 35.46 C ATOM 7864 CB ASN A 514 −58.342 19.343 15.903 1.00 35.39 C ATOM 7867 CG ASN A 514 −59.383 19.345 14.786 1.00 34.01 C ATOM 7868 OD1 ASN A 514 −59.336 20.185 13.896 1.00 33.36 O ATOM 7869 ND2 ASN A 514 −60.315 18.406 14.833 1.00 31.13 N ATOM 7872 C ASN A 514 −57.464 20.751 17.818 1.00 36.15 C ATOM 7873 O ASN A 514 −56.397 20.211 18.153 1.00 36.13 O ATOM 7875 N GLY A 515 −58.277 21.430 18.640 1.00 36.95 N ATOM 7876 CA GLY A 515 −58.427 21.235 20.079 1.00 37.43 C ATOM 7879 C GLY A 515 −59.724 20.470 20.381 1.00 38.18 C ATOM 7880 O GLY A 515 −59.636 19.418 21.021 1.00 38.57 O ATOM 7882 N ASP A 516 −60.930 20.921 19.969 1.00 38.73 N ATOM 7883 CA ASP A 516 −61.249 22.194 19.293 1.00 39.26 C ATOM 7885 CB ASP A 516 −61.607 21.904 17.845 1.00 39.51 C ATOM 7888 CG ASP A 516 −60.523 22.291 16.894 1.00 42.32 C ATOM 7889 OD1 ASP A 516 −59.613 23.084 17.286 1.00 45.56 O ATOM 7890 OD2 ASP A 516 −60.578 21.797 15.740 1.00 45.52 O ATOM 7891 C ASP A 516 −62.466 22.913 19.884 1.00 39.38 C ATOM 7892 O ASP A 516 −63.032 22.454 20.880 1.00 39.74 O ATOM 7894 N ALA A 517 −62.850 24.038 19.259 1.00 39.40 N ATOM 7895 CA ALA A 517 −64.140 24.752 19.481 1.00 39.50 C ATOM 7897 CB ALA A 517 −65.117 24.403 18.333 1.00 39.27 C ATOM 7901 C ALA A 517 −64.837 24.566 20.863 1.00 39.90 C ATOM 7902 O ALA A 517 −64.173 24.428 21.899 1.00 39.89 O ATOM 7904 N HIS A 518 −66.175 24.617 20.876 1.00 40.33 N ATOM 7905 CA HIS A 518 −66.973 24.112 22.016 1.00 40.73 C ATOM 7907 CB HIS A 518 −68.091 25.092 22.396 1.00 41.22 C ATOM 7910 CG HIS A 518 −67.578 26.419 22.866 1.00 43.58 C ATOM 7911 ND1 HIS A 518 −67.426 26.725 24.207 1.00 45.88 N ATOM 7913 CE1 HIS A 518 −66.938 27.950 24.320 1.00 46.42 C ATOM 7915 NE2 HIS A 518 −66.760 28.446 23.102 1.00 46.25 N ATOM 7917 CD2 HIS A 518 −67.145 27.506 22.174 1.00 45.24 C ATOM 7919 C HIS A 518 −67.526 22.725 21.655 1.00 40.17 C ATOM 7920 O HIS A 518 −68.738 22.501 21.571 1.00 40.02 O ATOM 7922 N THR A 519 −66.581 21.812 21.448 1.00 39.64 N ATOM 7923 CA THR A 519 −66.808 20.466 20.918 1.00 39.16 C ATOM 7925 CB THR A 519 −67.414 20.469 19.453 1.00 39.16 C ATOM 7927 OG1 THR A 519 −66.847 21.529 18.665 1.00 39.04 O ATOM 7929 CG2 THR A 519 −68.942 20.633 19.480 1.00 38.82 C ATOM 7933 C THR A 519 −65.428 19.771 20.978 1.00 38.85 C ATOM 7934 O THR A 519 −64.391 20.433 20.878 1.00 38.66 O ATOM 7936 N SER A 520 −65.407 18.455 21.170 1.00 38.37 N ATOM 7937 CA SER A 520 −64.160 17.745 21.500 1.00 38.08 C ATOM 7939 CB SER A 520 −64.514 16.320 21.931 1.00 38.06 C ATOM 7942 OG SER A 520 −64.560 15.475 20.805 1.00 38.66 O ATOM 7944 C SER A 520 −63.136 17.771 20.327 1.00 37.86 C ATOM 7945 O SER A 520 −63.420 18.369 19.289 1.00 37.50 O ATOM 7947 N PRO A 521 −61.948 17.122 20.482 1.00 37.98 N ATOM 7948 CA PRO A 521 −60.944 17.170 19.379 1.00 37.92 C ATOM 7950 CB PRO A 521 −59.674 16.527 19.987 1.00 37.87 C ATOM 7953 CG PRO A 521 −60.091 15.919 21.330 1.00 38.28 C ATOM 7956 CD PRO A 521 −61.577 16.137 21.526 1.00 38.13 C ATOM 7959 C PRO A 521 −61.432 16.446 18.110 1.00 37.96 C ATOM 7960 O PRO A 521 −61.769 17.118 17.140 1.00 38.09 O ATOM 7961 N ASP A 522 −61.483 15.108 18.107 1.00 38.07 N ATOM 7962 CA ASP A 522 −62.351 14.393 17.161 1.00 38.14 C ATOM 7964 CB ASP A 522 −62.132 12.877 17.204 1.00 38.31 C ATOM 7967 CG ASP A 522 −60.769 12.456 16.640 1.00 39.45 C ATOM 7968 OD1 ASP A 522 −60.160 13.200 15.827 1.00 39.72 O ATOM 7969 OD2 ASP A 522 −60.302 11.361 17.025 1.00 41.59 O ATOM 7970 C ASP A 522 −63.760 14.780 17.591 1.00 37.92 C ATOM 7971 O ASP A 522 −63.908 15.608 18.474 1.00 38.01 O ATOM 7973 N GLU A 523 −64.799 14.239 16.974 1.00 37.79 N ATOM 7974 CA GLU A 523 −66.150 14.818 17.121 1.00 37.83 C ATOM 7976 CB GLU A 523 −66.618 14.919 18.591 1.00 37.85 C ATOM 7979 CG GLU A 523 −66.346 13.678 19.483 1.00 39.40 C ATOM 7982 CD GLU A 523 −66.916 13.802 20.931 1.00 41.49 C ATOM 7983 OE1 GLU A 523 −67.714 14.737 21.207 1.00 42.81 O ATOM 7984 OE2 GLU A 523 −66.566 12.957 21.800 1.00 42.04 O ATOM 7985 C GLU A 523 −66.242 16.203 16.430 1.00 37.51 C ATOM 7986 O GLU A 523 −67.338 16.751 16.283 1.00 37.70 O ATOM 7988 N LEU A 524 −65.097 16.775 16.043 1.00 37.03 N ATOM 7989 CA LEU A 524 −65.044 17.863 15.067 1.00 36.58 C ATOM 7991 CB LEU A 524 −64.174 19.022 15.559 1.00 36.56 C ATOM 7994 CG LEU A 524 −63.963 20.225 14.624 1.00 36.35 C ATOM 7996 CD1 LEU A 524 −63.400 21.376 15.418 1.00 35.74 C ATOM 8000 CD2 LEU A 524 −65.242 20.681 13.910 1.00 36.53 C ATOM 8004 C LEU A 524 −64.478 17.287 13.782 1.00 36.20 C ATOM 8005 O LEU A 524 −65.106 17.363 12.733 1.00 36.14 O ATOM 8007 N THR A 525 −63.298 16.686 13.869 1.00 35.83 N ATOM 8008 CA THR A 525 −62.756 15.935 12.748 1.00 35.66 C ATOM 8010 CB THR A 525 −61.585 15.015 13.173 1.00 35.48 C ATOM 8012 OG1 THR A 525 −60.776 15.678 14.152 1.00 35.55 O ATOM 8014 CG2 THR A 525 −60.720 14.641 11.978 1.00 34.73 C ATOM 8018 C THR A 525 −63.875 15.098 12.123 1.00 35.89 C ATOM 8019 O THR A 525 −64.040 15.095 10.909 1.00 35.98 O ATOM 8021 N ARG A 526 −64.667 14.420 12.954 1.00 36.06 N ATOM 8022 CA ARG A 526 −65.739 13.574 12.448 1.00 36.18 C ATOM 8024 CB ARG A 526 −66.340 12.718 13.555 1.00 36.56 C ATOM 8027 CG ARG A 526 −67.416 11.754 13.054 1.00 38.35 C ATOM 8030 CD ARG A 526 −67.781 10.702 14.092 1.00 41.00 C ATOM 8033 NE ARG A 526 −67.740 11.207 15.470 1.00 43.08 N ATOM 8035 CZ ARG A 526 −68.637 12.033 16.024 1.00 44.51 C ATOM 8036 NH1 ARG A 526 −69.681 12.500 15.336 1.00 44.46 N ATOM 8039 NH2 ARG A 526 −68.476 12.406 17.288 1.00 45.02 N ATOM 8042 C ARG A 526 −66.834 14.384 11.774 1.00 35.68 C ATOM 8043 O ARG A 526 −67.253 14.035 10.675 1.00 35.84 O ATOM 8045 N LYS A 527 −67.309 15.447 12.424 1.00 35.06 N ATOM 8046 CA LYS A 527 −68.285 16.343 11.780 1.00 34.61 C ATOM 8048 CB LYS A 527 −68.680 17.528 12.683 1.00 34.74 C ATOM 8051 CG LYS A 527 −69.818 17.225 13.651 1.00 35.40 C ATOM 8054 CD LYS A 527 −70.301 18.452 14.441 1.00 35.99 C ATOM 8057 CE LYS A 527 −71.280 18.021 15.556 1.00 36.42 C ATOM 8060 NZ LYS A 527 −71.652 19.095 16.530 1.00 36.31 N ATOM 8064 C LYS A 527 −67.723 16.860 10.457 1.00 33.77 C ATOM 8065 O LYS A 527 −68.377 16.763 9.423 1.00 33.75 O ATOM 8067 N ARG A 528 −66.501 17.388 10.499 1.00 32.71 N ATOM 8068 CA ARG A 528 −65.840 17.929 9.310 1.00 31.79 C ATOM 8070 CB ARG A 528 −64.425 18.464 9.644 1.00 31.74 C ATOM 8073 CG ARG A 528 −64.419 19.844 10.330 1.00 30.90 C ATOM 8076 CD ARG A 528 −63.021 20.439 10.527 1.00 29.75 C ATOM 8079 NE ARG A 528 −63.098 21.745 11.190 1.00 29.55 N ATOM 8081 CZ ARG A 528 −62.056 22.513 11.528 1.00 29.96 C ATOM 8082 NH1 ARG A 528 −60.801 22.145 11.284 1.00 29.74 N ATOM 8085 NH2 ARG A 528 −62.269 23.677 12.130 1.00 30.71 N ATOM 8088 C ARG A 528 −65.796 16.904 8.172 1.00 30.99 C ATOM 8089 O ARG A 528 −66.226 17.206 7.068 1.00 30.97 O ATOM 8091 N VAL A 529 −65.313 15.694 8.450 1.00 30.12 N ATOM 8092 CA VAL A 529 −65.239 14.631 7.438 1.00 29.43 C ATOM 8094 CB VAL A 529 −64.557 13.354 7.972 1.00 29.39 C ATOM 8096 CG1 VAL A 529 −64.785 12.187 7.023 1.00 28.89 C ATOM 8100 CG2 VAL A 529 −63.062 13.589 8.186 1.00 29.44 C ATOM 8104 C VAL A 529 −66.609 14.243 6.887 1.00 28.95 C ATOM 8105 O VAL A 529 −66.755 14.016 5.690 1.00 29.09 O ATOM 8107 N LEU A 530 −67.615 14.153 7.744 1.00 28.18 N ATOM 8108 CA LEU A 530 −68.956 13.874 7.246 1.00 27.72 C ATOM 8110 CB LEU A 530 −69.971 13.715 8.395 1.00 27.75 C ATOM 8113 CG LEU A 530 −70.334 12.274 8.775 1.00 27.36 C ATOM 8115 CD1 LEU A 530 −69.096 11.415 9.050 1.00 26.86 C ATOM 8119 CD2 LEU A 530 −71.273 12.279 9.968 1.00 27.14 C ATOM 8123 C LEU A 530 −69.401 14.963 6.256 1.00 27.16 C ATOM 8124 O LEU A 530 −69.861 14.652 5.161 1.00 27.42 O ATOM 8126 N SER A 531 −69.230 16.229 6.635 1.00 26.21 N ATOM 8127 CA SER A 531 −69.730 17.359 5.853 1.00 25.12 C ATOM 8129 CB SER A 531 −69.519 18.657 6.618 1.00 25.01 C ATOM 8132 OG SER A 531 −68.167 18.791 6.985 1.00 23.94 O ATOM 8134 C SER A 531 −69.055 17.476 4.507 1.00 24.48 C ATOM 8135 O SER A 531 −69.687 17.886 3.538 1.00 24.14 O ATOM 8137 N VAL A 532 −67.774 17.115 4.461 1.00 23.89 N ATOM 8138 CA VAL A 532 −66.962 17.226 3.246 1.00 23.53 C ATOM 8140 CB VAL A 532 −65.470 17.437 3.575 1.00 23.09 C ATOM 8142 CG1 VAL A 532 −64.633 17.355 2.348 1.00 22.32 C ATOM 8146 CG2 VAL A 532 −65.268 18.773 4.198 1.00 23.07 C ATOM 8150 C VAL A 532 −67.100 16.028 2.316 1.00 23.67 C ATOM 8151 O VAL A 532 −67.137 16.209 1.099 1.00 23.58 O ATOM 8153 N ILE A 533 −67.187 14.824 2.886 1.00 23.85 N ATOM 8154 CA ILE A 533 −67.172 13.578 2.107 1.00 24.08 C ATOM 8156 CB ILE A 533 −66.172 12.555 2.691 1.00 24.10 C ATOM 8158 CG1 ILE A 533 −64.745 13.079 2.631 1.00 23.47 C ATOM 8161 CD1 ILE A 533 −64.178 13.083 1.255 1.00 23.42 C ATOM 8165 CG2 ILE A 533 −66.254 11.231 1.932 1.00 24.56 C ATOM 8169 C ILE A 533 −68.522 12.859 1.990 1.00 24.27 C ATOM 8170 O ILE A 533 −68.991 12.620 .887 1.00 24.34 O ATOM 8172 N THR A 534 −69.133 12.487 3.111 1.00 24.57 N ATOM 8173 CA THR A 534 −70.279 11.564 3.072 1.00 24.92 C ATOM 8175 CB THR A 534 −70.200 10.522 4.207 1.00 24.93 C ATOM 8177 OG1 THR A 534 −70.491 11.149 5.458 1.00 25.28 O ATOM 8179 CG2 THR A 534 −68.804 9.885 4.257 1.00 24.75 C ATOM 8183 C THR A 534 −71.673 12.209 3.083 1.00 25.00 C ATOM 8184 O THR A 534 −72.601 11.646 2.522 1.00 24.94 O ATOM 8186 N GLU A 535 −71.821 13.374 3.708 1.00 25.26 N ATOM 8187 CA GLU A 535 −73.132 14.024 3.833 1.00 25.34 C ATOM 8189 CB GLU A 535 −73.333 14.523 5.255 1.00 25.44 C ATOM 8192 CG GLU A 535 −73.753 13.424 6.196 1.00 25.80 C ATOM 8195 CD GLU A 535 −74.307 13.963 7.468 1.00 25.72 C ATOM 8196 OE1 GLU A 535 −75.375 13.487 7.881 1.00 24.50 O ATOM 8197 OE2 GLU A 535 −73.678 14.877 8.039 1.00 27.03 O ATOM 8198 C GLU A 535 −73.363 15.179 2.859 1.00 25.26 C ATOM 8199 O GLU A 535 −72.686 16.206 2.939 1.00 25.02 O ATOM 8201 N PRO A 536 −74.351 15.030 1.959 1.00 25.25 N ATOM 8202 CA PRO A 536 −74.655 16.111 1.050 1.00 25.18 C ATOM 8204 CB PRO A 536 −75.661 15.484 .076 1.00 25.15 C ATOM 8207 CG PRO A 536 −75.825 14.077 .476 1.00 24.98 C ATOM 8210 CD PRO A 536 −75.363 13.965 1.868 1.00 25.26 C ATOM 8213 C PRO A 536 −75.289 17.265 1.801 1.00 25.30 C ATOM 8214 O PRO A 536 −75.826 17.070 2.883 1.00 25.57 O ATOM 8215 N ILE A 537 −75.213 18.458 1.230 1.00 25.36 N ATOM 8216 CA ILE A 537 −75.807 19.638 1.827 1.00 25.34 C ATOM 8218 CB ILE A 537 −75.201 20.918 1.221 1.00 25.14 C ATOM 8220 CG1 ILE A 537 −73.787 21.131 1.744 1.00 24.32 C ATOM 8223 CD1 ILE A 537 −73.228 22.472 1.406 1.00 23.22 C ATOM 8227 CG2 ILE A 537 −76.030 22.131 1.569 1.00 25.54 C ATOM 8231 C ILE A 537 −77.313 19.603 1.611 1.00 25.67 C ATOM 8232 O ILE A 537 −77.786 19.132 .579 1.00 25.47 O ATOM 8234 N LEU A 538 −78.071 20.088 2.586 1.00 26.22 N ATOM 8235 CA LEU A 538 −79.514 20.051 2.467 1.00 26.65 C ATOM 8237 CB LEU A 538 −80.213 20.525 3.749 1.00 26.78 C ATOM 8240 CG LEU A 538 −80.162 19.609 4.989 1.00 26.64 C ATOM 8242 CD1 LEU A 538 −81.218 20.033 6.007 1.00 26.16 C ATOM 8246 CD2 LEU A 538 −80.346 18.138 4.633 1.00 26.12 C ATOM 8250 C LEU A 538 −79.925 20.881 1.262 1.00 27.08 C ATOM 8253 N PRO A 539 −80.786 20.306 .414 1.00 28.03 N ATOM 8254 CA PRO A 539 −81.117 20.855 −.888 1.00 28.44 C ATOM 8256 CB PRO A 539 −82.093 19.828 −1.449 1.00 28.40 C ATOM 8259 CG PRO A 539 −82.793 19.328 −.253 1.00 28.30 C ATOM 8262 CD PRO A 539 −81.720 19.228 .787 1.00 28.11 C ATOM 8265 C PRO A 539 −81.813 22.194 −.804 1.00 28.89 C ATOM 8266 O PRO A 539 −82.396 22.535 .226 1.00 28.97 O ATOM 8267 N PHE A 540 −81.774 22.932 −1.906 1.00 29.32 N ATOM 8268 CA PHE A 540 −82.380 24.245 −1.962 1.00 29.50 C ATOM 8270 CB PHE A 540 −82.146 24.874 −3.326 1.00 29.56 C ATOM 8273 CG PHE A 540 −82.757 26.227 −3.463 1.00 29.75 C ATOM 8274 CD1 PHE A 540 −83.874 26.429 −4.255 1.00 29.47 C ATOM 8276 CE1 PHE A 540 −84.441 27.681 −4.364 1.00 29.46 C ATOM 8278 CZ PHE A 540 −83.901 28.743 −3.674 1.00 29.81 C ATOM 8280 CE2 PHE A 540 −82.791 28.553 −2.877 1.00 30.21 C ATOM 8282 CD2 PHE A 540 −82.229 27.300 −2.770 1.00 30.17 C ATOM 8284 C PHE A 540 −83.865 24.129 −1.722 1.00 29.66 C ATOM 8285 O PHE A 540 −84.568 23.551 −2.545 1.00 29.66 O ATOM 8287 N GLU A 541 −84.337 24.673 −.601 1.00 29.90 N ATOM 8288 CA GLU A 541 −85.761 24.605 −.233 1.00 30.06 C ATOM 8290 CB GLU A 541 −85.951 23.724 1.017 1.00 30.15 C ATOM 8293 CG GLU A 541 −87.411 23.361 1.367 1.00 30.64 C ATOM 8296 CD GLU A 541 −88.091 24.351 2.322 1.00 31.35 C ATOM 8297 OE1 GLU A 541 −87.468 25.370 2.680 1.00 32.67 O ATOM 8298 OE2 GLU A 541 −89.254 24.114 2.719 1.00 30.48 O ATOM 8299 C GLU A 541 −86.315 26.011 −.010 1.00 29.89 C ATOM 8300 O GLU A 541 −86.835 26.636 −.936 1.00 29.71 O ATOM 8302 N LEU B 17 −69.666 −25.325 2.227 1.00 33.20 N ATOM 8303 CA LEU B 17 −69.356 −25.417 .755 1.00 33.49 C ATOM 8305 CB LEU B 17 −70.240 −26.475 .048 1.00 33.44 C ATOM 8308 CG LEU B 17 −70.077 −27.986 .328 1.00 33.60 C ATOM 8310 CD1 LEU B 17 −71.285 −28.778 −.217 1.00 32.76 C ATOM 8314 CD2 LEU B 17 −68.763 −28.553 −.230 1.00 33.21 C ATOM 8318 C LEU B 17 −69.513 −24.044 .055 1.00 33.54 C ATOM 8319 O LEU B 17 −70.550 −23.380 .195 1.00 33.77 O ATOM 8323 N LEU B 18 −68.481 −23.637 −.696 1.00 33.44 N ATOM 8324 CA LEU B 18 −68.476 −22.362 −1.454 1.00 33.07 C ATOM 8326 CB LEU B 18 −67.029 −21.960 −1.840 1.00 33.21 C ATOM 8329 CG LEU B 18 −66.065 −21.488 −.721 1.00 34.06 C ATOM 8331 CD1 LEU B 18 −64.607 −21.351 −1.235 1.00 34.51 C ATOM 8335 CD2 LEU B 18 −66.516 −20.164 −.061 1.00 33.43 C ATOM 8339 C LEU B 18 −69.379 −22.400 −2.714 1.00 32.37 C ATOM 8340 O LEU B 18 −69.710 −21.355 −3.274 1.00 32.29 O ATOM 8342 N SER B 19 −69.765 −23.597 −3.153 1.00 31.62 N ATOM 8343 CA SER B 19 −70.711 −23.749 −4.253 1.00 31.16 C ATOM 8345 CB SER B 19 −70.443 −25.067 −5.033 1.00 31.09 C ATOM 8348 OG SER B 19 −70.977 −26.243 −4.421 1.00 29.36 O ATOM 8350 C SER B 19 −72.168 −23.663 −3.759 1.00 31.45 C ATOM 8351 O SER B 19 −73.076 −23.432 −4.551 1.00 31.13 O ATOM 8353 N SER B 20 −72.386 −23.824 −2.451 1.00 31.91 N ATOM 8354 CA SER B 20 −73.749 −23.900 −1.879 1.00 32.34 C ATOM 8356 CB SER B 20 −73.706 −24.122 −.357 1.00 32.35 C ATOM 8359 OG SER B 20 −73.393 −25.473 −.055 1.00 32.34 O ATOM 8361 C SER B 20 −74.601 −22.670 −2.204 1.00 32.69 C ATOM 8362 O SER B 20 −74.072 −21.600 −2.487 1.00 32.89 O ATOM 8364 N ASP B 21 −75.921 −22.831 −2.119 1.00 33.13 N ATOM 8365 CA ASP B 21 −76.874 −21.901 −2.745 1.00 33.40 C ATOM 8367 CB ASP B 21 −78.179 −22.628 −3.045 1.00 33.64 C ATOM 8370 CG ASP B 21 −77.943 −23.883 −3.828 1.00 35.35 C ATOM 8371 OD1 ASP B 21 −77.031 −23.866 −4.684 1.00 38.26 O ATOM 8372 OD2 ASP B 21 −78.631 −24.890 −3.590 1.00 37.55 O ATOM 8373 C ASP B 21 −77.141 −20.649 −1.940 1.00 33.23 C ATOM 8374 O ASP B 21 −78.039 −20.616 −1.106 1.00 32.91 O ATOM 8376 N THR B 22 −76.348 −19.621 −2.229 1.00 33.46 N ATOM 8377 CA THR B 22 −76.443 −18.307 −1.593 1.00 33.79 C ATOM 8379 CB THR B 22 −76.460 −18.378 −.016 1.00 33.74 C ATOM 8381 OG1 THR B 22 −75.426 −19.250 .460 1.00 32.97 O ATOM 8383 CG2 THR B 22 −77.805 −18.838 .535 1.00 33.55 C ATOM 8387 C THR B 22 −75.217 −17.479 −2.018 1.00 34.24 C ATOM 8388 O THR B 22 −74.102 −17.988 −1.892 1.00 33.95 O ATOM 8390 N ASP B 23 −75.361 −16.248 −2.543 1.00 34.99 N ATOM 8391 CA ASP B 23 −76.603 −15.620 −3.103 1.00 35.61 C ATOM 8393 CB ASP B 23 −77.242 −16.538 −4.170 1.00 35.51 C ATOM 8396 CG ASP B 23 −76.196 −17.236 −5.034 1.00 36.08 C ATOM 8397 OD1 ASP B 23 −75.084 −16.685 −5.194 1.00 35.58 O ATOM 8398 OD2 ASP B 23 −76.473 −18.344 −5.541 1.00 37.65 O ATOM 8399 C ASP B 23 −77.662 −15.083 −2.097 1.00 36.10 C ATOM 8400 O ASP B 23 −78.644 −15.770 −1.799 1.00 36.13 O ATOM 8402 N GLU B 24 −77.487 −13.845 −1.616 1.00 36.74 N ATOM 8403 CA GLU B 24 −78.358 −13.316 −.543 1.00 37.59 C ATOM 8405 CB GLU B 24 −77.765 −13.666 .838 1.00 37.88 C ATOM 8408 CG GLU B 24 −77.624 −15.173 1.120 1.00 38.51 C ATOM 8411 CD GLU B 24 −77.314 −15.510 2.588 1.00 39.48 C ATOM 8412 OE1 GLU B 24 −77.171 −14.581 3.434 1.00 39.60 O ATOM 8413 OE2 GLU B 24 −77.221 −16.725 2.884 1.00 39.51 O ATOM 8414 C GLU B 24 −78.730 −11.809 −.559 1.00 38.11 C ATOM 8415 O GLU B 24 −79.840 −11.453 −.972 1.00 38.20 O ATOM 8417 N SER B 25 −77.825 −10.941 −.089 1.00 38.70 N ATOM 8418 CA SER B 25 −78.192 −9.560 .312 1.00 39.21 C ATOM 8420 CB SER B 25 −76.995 −8.783 .916 1.00 39.29 C ATOM 8423 OG SER B 25 −76.267 −8.037 −.056 1.00 39.40 O ATOM 8425 C SER B 25 −78.853 −8.738 −.802 1.00 39.69 C ATOM 8426 O SER B 25 −78.707 −9.050 −1.995 1.00 39.75 O ATOM 8428 N ILE B 26 −79.544 −7.670 −.378 1.00 40.21 N ATOM 8429 CA ILE B 26 −80.554 −6.962 −1.189 1.00 40.55 C ATOM 8431 CB ILE B 26 −79.925 −6.082 −2.319 1.00 40.66 C ATOM 8433 CG1 ILE B 26 −79.083 −4.951 −1.700 1.00 40.73 C ATOM 8436 CD1 ILE B 26 −78.596 −3.877 −2.698 1.00 40.68 C ATOM 8440 CG2 ILE B 26 −81.018 −5.475 −3.203 1.00 40.88 C ATOM 8444 C ILE B 26 −81.575 −7.999 −1.714 1.00 40.72 C ATOM 8445 O ILE B 26 −81.311 −8.710 −2.690 1.00 40.80 O ATOM 8447 N GLU B 27 −82.729 −8.070 −1.037 1.00 40.86 N ATOM 8448 CA GLU B 27 −83.694 −9.190 −1.160 1.00 40.88 C ATOM 8450 CB GLU B 27 −84.782 −9.060 −.061 1.00 40.95 C ATOM 8453 CG GLU B 27 −84.235 −9.257 1.379 1.00 41.28 C ATOM 8456 CD GLU B 27 −85.123 −8.657 2.484 1.00 41.74 C ATOM 8457 OE1 GLU B 27 −85.593 −7.504 2.344 1.00 41.14 O ATOM 8458 OE2 GLU B 27 −85.332 −9.337 3.514 1.00 42.36 O ATOM 8459 C GLU B 27 −84.290 −9.355 −2.587 1.00 40.75 C ATOM 8460 O GLU B 27 −83.664 −8.936 −3.569 1.00 40.88 O ATOM 8462 N VAL B 28 −85.461 −9.994 −2.712 1.00 40.40 N ATOM 8463 CA VAL B 28 −86.033 −10.361 −4.027 1.00 39.97 C ATOM 8465 CB VAL B 28 −86.034 −9.157 −5.053 1.00 40.03 C ATOM 8467 CG1 VAL B 28 −86.494 −9.600 −6.444 1.00 39.63 C ATOM 8471 CG2 VAL B 28 −86.900 −7.994 −4.525 1.00 39.86 C ATOM 8475 C VAL B 28 −85.335 −11.600 −4.625 1.00 39.63 C ATOM 8476 O VAL B 28 −85.858 −12.204 −5.567 1.00 39.63 O ATOM 8478 N HIS B 29 −84.175 −11.980 −4.069 1.00 39.21 N ATOM 8479 CA HIS B 29 −83.431 −13.177 −4.504 1.00 38.81 C ATOM 8481 CB HIS B 29 −81.914 −12.913 −4.665 1.00 38.97 C ATOM 8484 CG HIS B 29 −81.571 −11.721 −5.512 1.00 39.99 C ATOM 8485 ND1 HIS B 29 −81.181 −11.825 −6.834 1.00 40.79 N ATOM 8487 CE1 HIS B 29 −80.931 −10.615 −7.312 1.00 40.76 C ATOM 8489 NE2 HIS B 29 −81.134 −9.734 −6.346 1.00 40.27 N ATOM 8491 CD2 HIS B 29 −81.525 −10.400 −5.209 1.00 40.17 C ATOM 8493 C HIS B 29 −83.611 −14.340 −3.523 1.00 38.05 C ATOM 8494 O HIS B 29 −82.782 −15.259 −3.526 1.00 38.02 O ATOM 8496 N LYS B 30 −84.667 −14.321 −2.694 1.00 37.06 N ATOM 8497 CA LYS B 30 −85.107 −15.559 −2.022 1.00 36.33 C ATOM 8499 CB LYS B 30 −86.056 −15.286 −.836 1.00 36.27 C ATOM 8502 CG LYS B 30 −85.352 −14.818 .461 1.00 36.09 C ATOM 8505 CD LYS B 30 −86.355 −14.599 1.612 1.00 36.03 C ATOM 8508 CE LYS B 30 −85.811 −13.659 2.701 1.00 36.24 C ATOM 8511 NZ LYS B 30 −86.802 −13.356 3.789 1.00 35.65 N ATOM 8515 C LYS B 30 −85.710 −16.510 −3.094 1.00 35.69 C ATOM 8516 O LYS B 30 −86.706 −17.205 −2.879 1.00 35.35 O ATOM 8518 N ASP B 31 −85.075 −16.484 −4.268 1.00 35.13 N ATOM 8519 CA ASP B 31 −85.145 −17.519 −5.282 1.00 34.64 C ATOM 8521 CB ASP B 31 −84.592 −16.962 −6.623 1.00 34.60 C ATOM 8524 CG ASP B 31 −84.419 −18.032 −7.725 1.00 34.24 C ATOM 8525 OD1 ASP B 31 −84.914 −19.165 −7.570 1.00 34.58 O ATOM 8526 OD2 ASP B 31 −83.776 −17.732 −8.761 1.00 31.56 O ATOM 8527 C ASP B 31 −84.304 −18.675 −4.721 1.00 34.31 C ATOM 8528 O ASP B 31 −83.122 −18.838 −5.038 1.00 34.03 O ATOM 8530 N LYS B 32 −84.917 −19.429 −3.813 1.00 33.94 N ATOM 8531 CA LYS B 32 −84.380 −20.710 −3.369 1.00 33.36 C ATOM 8533 CB LYS B 32 −83.772 −20.607 −1.973 1.00 33.45 C ATOM 8536 CG LYS B 32 −82.540 −19.693 −1.951 1.00 33.56 C ATOM 8539 CD LYS B 32 −82.025 −19.455 −.532 1.00 34.17 C ATOM 8542 CE LYS B 32 −81.671 −17.987 −.283 1.00 34.16 C ATOM 8545 NZ LYS B 32 −80.746 −17.437 −1.311 1.00 34.07 N ATOM 8549 C LYS B 32 −85.490 −21.764 −3.499 1.00 32.57 C ATOM 8550 O LYS B 32 −85.908 −22.412 −2.538 1.00 32.10 O ATOM 8552 N ALA B 33 −85.976 −21.859 −4.738 1.00 31.66 N ATOM 8553 CA ALA B 33 −86.576 −23.055 −5.259 1.00 30.94 C ATOM 8555 CB ALA B 33 −87.247 −22.773 −6.597 1.00 30.47 C ATOM 8559 C ALA B 33 −85.442 −24.081 −5.403 1.00 30.55 C ATOM 8560 O ALA B 33 −85.684 −25.230 −5.751 1.00 31.12 O ATOM 8562 N LYS B 34 −84.200 −23.660 −5.161 1.00 29.73 N ATOM 8563 CA LYS B 34 −83.107 −24.585 −4.839 1.00 29.09 C ATOM 8565 CB LYS B 34 −81.776 −23.817 −4.865 1.00 29.30 C ATOM 8568 CG LYS B 34 −80.678 −24.474 −5.726 1.00 29.76 C ATOM 8571 CD LYS B 34 −79.633 −23.458 −6.283 1.00 28.74 C ATOM 8574 CE LYS B 34 −78.417 −24.186 −6.890 1.00 27.56 C ATOM 8577 NZ LYS B 34 −78.745 −25.174 −7.935 1.00 26.16 N ATOM 8581 C LYS B 34 −83.376 −25.320 −3.472 1.00 28.37 C ATOM 8582 O LYS B 34 −83.254 −24.755 −2.374 1.00 27.82 O ATOM 8584 N LYS B 35 −83.635 −26.620 −3.604 1.00 27.53 N ATOM 8585 CA LYS B 35 −84.629 −27.429 −2.851 1.00 26.77 C ATOM 8587 CB LYS B 35 −85.729 −26.602 −2.170 1.00 26.81 C ATOM 8590 CG LYS B 35 −87.089 −26.520 −2.907 1.00 27.05 C ATOM 8593 CD LYS B 35 −88.096 −27.604 −2.452 1.00 27.41 C ATOM 8596 CE LYS B 35 −89.394 −27.636 −3.300 1.00 27.21 C ATOM 8599 NZ LYS B 35 −90.501 −26.792 −2.762 1.00 26.28 N ATOM 8603 C LYS B 35 −85.257 −28.357 −3.920 1.00 26.03 C ATOM 8604 O LYS B 35 −85.853 −29.386 −3.626 1.00 26.00 O ATOM 8606 N LEU B 36 −85.171 −27.909 −5.168 1.00 24.98 N ATOM 8607 CA LEU B 36 −85.095 −28.783 −6.319 1.00 24.02 C ATOM 8609 CB LEU B 36 −85.004 −27.930 −7.594 1.00 23.83 C ATOM 8612 CG LEU B 36 −86.208 −27.103 −8.062 1.00 22.23 C ATOM 8614 CD1 LEU B 36 −85.762 −25.873 −8.802 1.00 19.93 C ATOM 8618 CD2 LEU B 36 −87.092 −27.930 −8.951 1.00 22.11 C ATOM 8622 C LEU B 36 −83.834 −29.659 −6.185 1.00 23.58 C ATOM 8623 O LEU B 36 −83.840 −30.842 −6.508 1.00 23.38 O ATOM 8625 N GLU B 37 −82.742 −29.046 −5.739 1.00 23.18 N ATOM 8626 CA GLU B 37 −81.510 −29.753 −5.396 1.00 22.88 C ATOM 8628 CB GLU B 37 −80.466 −28.766 −4.855 1.00 22.76 C ATOM 8631 CG GLU B 37 −79.038 −29.297 −4.874 1.00 22.24 C ATOM 8634 CD GLU B 37 −78.085 −28.505 −4.009 1.00 21.06 C ATOM 8635 OE1 GLU B 37 −78.368 −27.331 −3.737 1.00 19.65 O ATOM 8636 OE2 GLU B 37 −77.037 −29.059 −3.615 1.00 20.62 O ATOM 8637 C GLU B 37 −81.748 −30.856 −4.364 1.00 22.95 C ATOM 8638 O GLU B 37 −81.164 −31.933 −4.458 1.00 22.99 O ATOM 8640 N ALA B 38 −82.591 −30.575 −3.372 1.00 23.02 N ATOM 8641 CA ALA B 38 −82.973 −31.565 −2.364 1.00 22.93 C ATOM 8643 CB ALA B 38 −83.966 −30.959 −1.374 1.00 22.73 C ATOM 8647 C ALA B 38 −83.580 −32.778 −3.044 1.00 23.05 C ATOM 8648 O ALA B 38 −83.170 −33.909 −2.813 1.00 22.52 O ATOM 8650 N GLU B 39 −84.546 −32.506 −3.912 1.00 23.66 N ATOM 8651 CA GLU B 39 −85.273 −33.534 −4.642 1.00 24.08 C ATOM 8653 CB GLU B 39 −86.403 −32.891 −5.453 1.00 24.28 C ATOM 8656 CG GLU B 39 −87.405 −33.869 −6.075 1.00 25.14 C ATOM 8659 CD GLU B 39 −88.773 −33.227 −6.341 1.00 26.43 C ATOM 8660 OE1 GLU B 39 −89.232 −32.381 −5.519 1.00 25.90 O ATOM 8661 OE2 GLU B 39 −89.387 −33.584 −7.375 1.00 26.99 O ATOM 8662 C GLU B 39 −84.362 −34.359 −5.545 1.00 24.18 C ATOM 8663 O GLU B 39 −84.483 −35.579 −5.575 1.00 24.32 O ATOM 8665 N VAL B 40 −83.450 −33.710 −6.269 1.00 24.43 N ATOM 8666 CA VAL B 40 −82.533 −34.437 −7.153 1.00 24.59 C ATOM 8668 CB VAL B 40 −81.734 −33.496 −8.087 1.00 24.65 C ATOM 8670 CG1 VAL B 40 −80.611 −34.258 −8.792 1.00 24.14 C ATOM 8674 CG2 VAL B 40 −82.662 −32.852 −9.106 1.00 23.89 C ATOM 8678 C VAL B 40 −81.592 −35.304 −6.328 1.00 24.99 C ATOM 8679 O VAL B 40 −81.265 −36.407 −6.717 1.00 24.77 O ATOM 8681 N ARG B 41 −81.184 −34.811 −5.171 1.00 25.79 N ATOM 8682 CA ARG B 41 −80.387 −35.613 −4.248 1.00 26.75 C ATOM 8684 CB ARG B 41 −80.032 −34.823 −2.998 1.00 27.38 C ATOM 8687 CG ARG B 41 −78.568 −34.777 −2.757 1.00 30.18 C ATOM 8690 CD ARG B 41 −78.281 −34.610 −1.273 1.00 34.43 C ATOM 8693 NE ARG B 41 −76.896 −34.198 −1.016 1.00 37.07 N ATOM 8695 CZ ARG B 41 −76.350 −33.045 −1.416 1.00 38.54 C ATOM 8696 NH1 ARG B 41 −75.083 −32.797 −1.112 1.00 40.04 N ATOM 8699 NH2 ARG B 41 −77.037 −32.145 −2.128 1.00 38.45 N ATOM 8702 C ARG B 41 −81.081 −36.860 −3.762 1.00 26.60 C ATOM 8703 O ARG B 41 −80.446 −37.894 −3.627 1.00 26.89 O ATOM 8705 N ARG B 42 −82.363 −36.733 −3.423 1.00 26.41 N ATOM 8706 CA ARG B 42 −83.159 −37.870 −3.002 1.00 26.09 C ATOM 8708 CB ARG B 42 −84.588 −37.452 −2.674 1.00 25.99 C ATOM 8711 CG ARG B 42 −85.426 −38.562 −2.049 1.00 25.45 C ATOM 8714 CD ARG B 42 −86.783 −38.078 −1.645 1.00 24.26 C ATOM 8717 NE ARG B 42 −87.549 −37.602 −2.794 1.00 23.73 N ATOM 8719 CZ ARG B 42 −88.547 −36.722 −2.717 1.00 24.51 C ATOM 8720 NH1 ARG B 42 −88.912 −36.195 −1.545 1.00 24.99 N ATOM 8723 NH2 ARG B 42 −89.185 −36.354 −3.816 1.00 24.46 N ATOM 8726 C ARG B 42 −83.167 −38.894 −4.118 1.00 26.28 C ATOM 8727 O ARG B 42 −82.864 −40.054 −3.888 1.00 26.39 O ATOM 8729 N GLU B 43 −83.476 −38.460 −5.334 1.00 26.52 N ATOM 8730 CA GLU B 43 −83.476 −39.370 −6.479 1.00 27.00 C ATOM 8732 CB GLU B 43 −83.982 −38.676 −7.753 1.00 27.50 C ATOM 8735 CG GLU B 43 −85.469 −38.275 −7.699 1.00 29.78 C ATOM 8738 CD GLU B 43 −86.342 −39.301 −6.974 1.00 32.52 C ATOM 8739 OE1 GLU B 43 −86.388 −40.455 −7.445 1.00 35.06 O ATOM 8740 OE2 GLU B 43 −86.966 −38.963 −5.936 1.00 33.80 O ATOM 8741 C GLU B 43 −82.147 −40.059 −6.769 1.00 26.37 C ATOM 8742 O GLU B 43 −82.162 −41.126 −7.355 1.00 26.63 O ATOM 8744 N ILE B 44 −81.018 −39.472 −6.373 1.00 25.85 N ATOM 8745 CA ILE B 44 −79.717 −40.126 −6.555 1.00 25.55 C ATOM 8747 CB ILE B 44 −78.547 −39.121 −6.692 1.00 25.26 C ATOM 8749 CG1 ILE B 44 −78.706 −38.273 −7.953 1.00 24.47 C ATOM 8752 CD1 ILE B 44 −77.690 −37.163 −8.114 1.00 23.21 C ATOM 8756 CG2 ILE B 44 −77.207 −39.863 −6.778 1.00 25.35 C ATOM 8760 C ILE B 44 −79.404 −41.109 −5.428 1.00 25.84 C ATOM 8761 O ILE B 44 −78.925 −42.208 −5.698 1.00 25.97 O ATOM 8763 N ASN B 45 −79.663 −40.708 −4.177 1.00 26.25 N ATOM 8764 CA ASN B 45 −79.403 −41.542 −2.983 1.00 26.34 C ATOM 8766 CB ASN B 45 −79.284 −40.681 −1.719 1.00 26.01 C ATOM 8769 CG ASN B 45 −78.072 −39.789 −1.723 1.00 24.65 C ATOM 8770 OD1 ASN B 45 −76.957 −40.226 −1.434 1.00 22.47 O ATOM 8771 ND2 ASN B 45 −78.288 −38.516 −2.009 1.00 23.36 N ATOM 8774 C ASN B 45 −80.488 −42.586 −2.731 1.00 27.18 C ATOM 8775 O ASN B 45 −80.374 −43.390 −1.806 1.00 27.30 O ATOM 8777 N ASN B 46 −81.553 −42.541 −3.527 1.00 28.17 N ATOM 8778 CA ASN B 46 −82.619 −43.536 −3.489 1.00 29.02 C ATOM 8780 CB ASN B 46 −83.558 −43.289 −4.665 1.00 29.05 C ATOM 8783 CG ASN B 46 −84.615 −44.345 −4.806 1.00 28.82 C ATOM 8784 OD1 ASN B 46 −84.861 −45.132 −3.895 1.00 28.14 O ATOM 8785 ND2 ASN B 46 −85.255 −44.369 −5.968 1.00 29.67 N ATOM 8788 C ASN B 46 −82.076 −44.958 −3.549 1.00 30.14 C ATOM 8789 O ASN B 46 −81.566 −45.408 −4.581 1.00 30.30 O ATOM 8791 N GLU B 47 −82.218 −45.674 −2.446 1.00 31.36 N ATOM 8792 CA GLU B 47 −81.575 −46.968 −2.295 1.00 32.61 C ATOM 8794 CB GLU B 47 −81.617 −47.430 −.823 1.00 33.09 C ATOM 8797 CG GLU B 47 −80.974 −46.466 .218 1.00 34.19 C ATOM 8800 CD GLU B 47 −81.919 −45.337 .721 1.00 34.57 C ATOM 8801 OE1 GLU B 47 −82.911 −45.012 .029 1.00 34.53 O ATOM 8802 OE2 GLU B 47 −81.652 −44.762 1.805 1.00 34.30 O ATOM 8803 C GLU B 47 −82.205 −48.046 −3.172 1.00 33.18 C ATOM 8804 O GLU B 47 −81.604 −49.088 −3.370 1.00 33.44 O ATOM 8806 N LYS B 48 −83.408 −47.808 −3.692 1.00 34.11 N ATOM 8807 CA LYS B 48 −84.164 −48.853 −4.396 1.00 34.85 C ATOM 8809 CB LYS B 48 −85.379 −49.254 −3.542 1.00 35.09 C ATOM 8812 CG LYS B 48 −85.003 −49.723 −2.127 1.00 36.00 C ATOM 8815 CD LYS B 48 −86.174 −50.338 −1.350 1.00 37.13 C ATOM 8818 CE LYS B 48 −87.312 −49.340 −1.094 1.00 37.90 C ATOM 8821 NZ LYS B 48 −86.908 −48.161 −.272 1.00 38.31 N ATOM 8825 C LYS B 48 −84.586 −48.487 −5.835 1.00 35.13 C ATOM 8826 O LYS B 48 −85.544 −49.030 −6.361 1.00 34.60 O ATOM 8828 N ALA B 49 −83.858 −47.576 −6.474 1.00 36.09 N ATOM 8829 CA ALA B 49 −84.093 −47.261 −7.886 1.00 36.87 C ATOM 8831 CB ALA B 49 −83.550 −45.880 −8.238 1.00 36.73 C ATOM 8835 C ALA B 49 −83.406 −48.325 −8.714 1.00 37.56 C ATOM 8836 O ALA B 49 −82.315 −48.761 −8.363 1.00 37.62 O ATOM 8838 N GLU B 50 −84.028 −48.754 −9.807 1.00 38.54 N ATOM 8839 CA GLU B 50 −83.399 −49.772 −10.652 1.00 39.40 C ATOM 8841 CB GLU B 50 −84.380 −50.384 −11.673 1.00 39.71 C ATOM 8844 CG GLU B 50 −83.959 −51.808 −12.179 1.00 41.33 C ATOM 8847 CD GLU B 50 −83.733 −52.860 −11.039 1.00 42.88 C ATOM 8848 OE1 GLU B 50 −84.683 −53.628 −10.718 1.00 42.94 O ATOM 8849 OE2 GLU B 50 −82.603 −52.921 −10.472 1.00 42.96 O ATOM 8850 C GLU B 50 −82.171 −49.163 −11.330 1.00 39.43 C ATOM 8851 O GLU B 50 −82.211 −48.017 −11.791 1.00 39.66 O ATOM 8853 N PHE B 51 −81.084 −49.929 −11.376 1.00 39.32 N ATOM 8854 CA PHE B 51 −79.763 −49.360 −11.636 1.00 39.32 C ATOM 8856 CB PHE B 51 −78.675 −50.429 −11.476 1.00 39.62 C ATOM 8859 CG PHE B 51 −78.470 −50.889 −10.032 1.00 41.82 C ATOM 8860 CD1 PHE B 51 −78.093 −49.978 −9.032 1.00 42.93 C ATOM 8862 CE1 PHE B 51 −77.892 −50.391 −7.705 1.00 43.30 C ATOM 8864 CZ PHE B 51 −78.059 −51.729 −7.359 1.00 44.33 C ATOM 8866 CE2 PHE B 51 −78.430 −52.659 −8.341 1.00 44.75 C ATOM 8868 CD2 PHE B 51 −78.633 −52.234 −9.677 1.00 44.06 C ATOM 8870 C PHE B 51 −79.646 −48.625 −12.976 1.00 38.57 C ATOM 8871 O PHE B 51 −79.045 −47.564 −13.046 1.00 38.50 O ATOM 8873 N LEU B 52 −80.262 −49.155 −14.024 1.00 37.99 N ATOM 8874 CA LEU B 52 −80.176 −48.539 −15.351 1.00 37.42 C ATOM 8876 CB LEU B 52 −80.774 −49.476 −16.399 1.00 37.66 C ATOM 8879 CG LEU B 52 −80.502 −49.168 −17.876 1.00 38.39 C ATOM 8881 CD1 LEU B 52 −80.171 −50.452 −18.652 1.00 38.46 C ATOM 8885 CD2 LEU B 52 −81.703 −48.432 −18.500 1.00 39.23 C ATOM 8889 C LEU B 52 −80.824 −47.143 −15.431 1.00 36.69 C ATOM 8890 O LEU B 52 −80.383 −46.312 −16.224 1.00 36.59 O ATOM 8892 N THR B 53 −81.859 −46.879 −14.625 1.00 35.87 N ATOM 8893 CA THR B 53 −82.409 −45.510 −14.513 1.00 34.91 C ATOM 8895 CB THR B 53 −83.784 −45.421 −13.805 1.00 34.72 C ATOM 8897 OG1 THR B 53 −84.724 −46.269 −14.455 1.00 34.04 O ATOM 8899 CG2 THR B 53 −84.316 −43.981 −13.855 1.00 34.81 C ATOM 8903 C THR B 53 −81.454 −44.642 −13.722 1.00 34.05 C ATOM 8904 O THR B 53 −81.170 −43.513 −14.121 1.00 34.16 O ATOM 8906 N LEU B 54 −80.987 −45.167 −12.593 1.00 32.84 N ATOM 8907 CA LEU B 54 −80.027 −44.461 −11.772 1.00 32.16 C ATOM 8909 CB LEU B 54 −79.506 −45.354 −10.662 1.00 32.27 C ATOM 8912 CG LEU B 54 −78.521 −44.702 −9.698 1.00 32.56 C ATOM 8914 CD1 LEU B 54 −79.275 −43.760 −8.769 1.00 32.38 C ATOM 8918 CD2 LEU B 54 −77.755 −45.789 −8.917 1.00 33.29 C ATOM 8922 C LEU B 54 −78.870 −44.006 −12.634 1.00 31.50 C ATOM 8923 O LEU B 54 −78.509 −42.840 −12.607 1.00 31.98 O ATOM 8925 N LEU B 55 −78.297 −44.914 −13.418 1.00 30.43 N ATOM 8926 CA LEU B 55 −77.220 −44.540 −14.333 1.00 29.36 C ATOM 8928 CB LEU B 55 −76.765 −45.733 −15.173 1.00 29.23 C ATOM 8931 CG LEU B 55 −76.157 −46.902 −14.391 1.00 28.60 C ATOM 8933 CD1 LEU B 55 −75.697 −48.004 −15.348 1.00 27.60 C ATOM 8937 CD2 LEU B 55 −75.020 −46.440 −13.469 1.00 27.20 C ATOM 8941 C LEU B 55 −77.678 −43.406 −15.230 1.00 28.60 C ATOM 8942 O LEU B 55 −77.063 −42.365 −15.267 1.00 28.17 O ATOM 8944 N GLU B 56 −78.786 −43.594 −15.919 1.00 28.23 N ATOM 8945 CA GLU B 56 −79.326 −42.530 −16.759 1.00 28.64 C ATOM 8947 CB GLU B 56 −80.567 −43.031 −17.524 1.00 29.27 C ATOM 8950 CG GLU B 56 −80.229 −43.783 −18.829 1.00 31.73 C ATOM 8953 CD GLU B 56 −81.265 −44.860 −19.206 1.00 35.52 C ATOM 8954 OE1 GLU B 56 −82.474 −44.693 −18.889 1.00 36.97 O ATOM 8955 OE2 GLU B 56 −80.856 −45.877 −19.825 1.00 37.55 O ATOM 8956 C GLU B 56 −79.632 −41.203 −15.995 1.00 27.77 C ATOM 8957 O GLU B 56 −79.561 −40.103 −16.582 1.00 27.84 O ATOM 8959 N LEU B 57 −79.976 −41.303 −14.710 1.00 26.29 N ATOM 8960 CA LEU B 57 −80.158 −40.120 −13.895 1.00 25.06 C ATOM 8962 CB LEU B 57 −80.724 −40.462 −12.514 1.00 24.83 C ATOM 8965 CG LEU B 57 −80.952 −39.298 −11.544 1.00 23.72 C ATOM 8967 CD1 LEU B 57 −81.909 −38.278 −12.117 1.00 21.43 C ATOM 8971 CD2 LEU B 57 −81.477 −39.830 −10.227 1.00 22.41 C ATOM 8975 C LEU B 57 −78.801 −39.459 −13.780 1.00 24.40 C ATOM 8976 O LEU B 57 −78.591 −38.373 −14.306 1.00 24.70 O ATOM 8978 N ILE B 58 −77.855 −40.133 −13.144 1.00 23.56 N ATOM 8979 CA ILE B 58 −76.509 −39.574 −12.991 1.00 22.91 C ATOM 8981 CB ILE B 58 −75.454 −40.635 −12.599 1.00 22.49 C ATOM 8983 CG1 ILE B 58 −75.753 −41.251 −11.235 1.00 22.09 C ATOM 8986 CD1 ILE B 58 −74.936 −42.464 −10.926 1.00 20.88 C ATOM 8990 CG2 ILE B 58 −74.103 −39.992 −12.534 1.00 22.63 C ATOM 8994 C ILE B 58 −76.062 −38.927 −14.302 1.00 22.64 C ATOM 8995 O ILE B 58 −75.603 −37.796 −14.315 1.00 22.38 O ATOM 8997 N ASP B 59 −76.228 −39.646 −15.404 1.00 22.56 N ATOM 8998 CA ASP B 59 −75.715 −39.196 −16.684 1.00 22.76 C ATOM 9000 CB ASP B 59 −75.926 −40.269 −17.757 1.00 22.93 C ATOM 9003 CG ASP B 59 −75.274 −39.904 −19.088 1.00 24.58 C ATOM 9004 OD1 ASP B 59 −74.157 −39.322 −19.081 1.00 25.70 O ATOM 9005 OD2 ASP B 59 −75.897 −40.186 −20.142 1.00 27.51 O ATOM 9006 C ASP B 59 −76.343 −37.863 −17.104 1.00 22.40 C ATOM 9007 O ASP B 59 −75.634 −36.939 −17.520 1.00 22.40 O ATOM 9009 N ASN B 60 −77.662 −37.767 −16.991 1.00 21.91 N ATOM 9010 CA ASN B 60 −78.349 −36.500 −17.217 1.00 21.70 C ATOM 9012 CB ASN B 60 −79.867 −36.674 −17.088 1.00 22.12 C ATOM 9015 CG ASN B 60 −80.477 −37.390 −18.268 1.00 22.76 C ATOM 9016 OD1 ASN B 60 −80.027 −37.233 −19.393 1.00 24.28 O ATOM 9017 ND2 ASN B 60 −81.515 −38.172 −18.017 1.00 24.36 N ATOM 9020 C ASN B 60 −77.898 −35.427 −16.234 1.00 21.17 C ATOM 9021 O ASN B 60 −77.700 −34.273 −16.614 1.00 20.85 O ATOM 9023 N VAL B 61 −77.745 −35.805 −14.968 1.00 20.60 N ATOM 9024 CA VAL B 61 −77.382 −34.841 −13.942 1.00 20.48 C ATOM 9026 CB VAL B 61 −77.277 −35.490 −12.551 1.00 20.26 C ATOM 9028 CG1 VAL B 61 −76.585 −34.562 −11.565 1.00 19.92 C ATOM 9032 CG2 VAL B 61 −78.668 −35.857 −12.049 1.00 20.66 C ATOM 9036 C VAL B 61 −76.068 −34.208 −14.335 1.00 20.66 C ATOM 9037 O VAL B 61 −75.871 −32.998 −14.182 1.00 20.74 O ATOM 9039 N GLN B 62 −75.187 −35.048 −14.875 1.00 20.92 N ATOM 9040 CA GLN B 62 −73.854 −34.636 −15.285 1.00 20.69 C ATOM 9042 CB GLN B 62 −72.917 −35.847 −15.404 1.00 20.77 C ATOM 9045 CG GLN B 62 −72.456 −36.369 −14.035 1.00 20.91 C ATOM 9048 CD GLN B 62 −71.328 −37.383 −14.112 1.00 20.75 C ATOM 9049 OE1 GLN B 62 −70.512 −37.498 −13.192 1.00 20.93 O ATOM 9050 NE2 GLN B 62 −71.291 −38.135 −15.195 1.00 20.39 N ATOM 9053 C GLN B 62 −73.900 −33.834 −16.567 1.00 20.32 C ATOM 9054 O GLN B 62 −73.410 −32.712 −16.569 1.00 20.79 O ATOM 9056 N ARG B 63 −74.512 −34.373 −17.625 1.00 19.87 N ATOM 9057 CA ARG B 63 −74.520 −33.696 −18.940 1.00 19.81 C ATOM 9059 CB ARG B 63 −75.240 −34.536 −20.013 1.00 19.75 C ATOM 9062 CG ARG B 63 −74.492 −35.846 −20.345 1.00 21.69 C ATOM 9065 CD ARG B 63 −75.158 −36.786 −21.368 1.00 24.89 C ATOM 9068 NE ARG B 63 −74.674 −36.558 −22.741 1.00 29.32 N ATOM 9070 CZ ARG B 63 −75.323 −35.878 −23.702 1.00 33.71 C ATOM 9071 NH1 ARG B 63 −76.537 −35.345 −23.510 1.00 36.67 N ATOM 9074 NH2 ARG B 63 −74.761 −35.736 −24.894 1.00 34.58 N ATOM 9077 C ARG B 63 −75.099 −32.276 −18.822 1.00 19.39 C ATOM 9078 O ARG B 63 −74.553 −31.310 −19.395 1.00 19.63 O ATOM 9080 N LEU B 64 −76.155 −32.148 −18.017 1.00 18.62 N ATOM 9081 CA LEU B 64 −76.811 −30.856 −17.753 1.00 17.96 C ATOM 9083 CB LEU B 64 −78.136 −31.077 −17.008 1.00 17.97 C ATOM 9086 CG LEU B 64 −79.264 −31.737 −17.809 1.00 17.08 C ATOM 9088 CD1 LEU B 64 −80.276 −32.354 −16.879 1.00 15.15 C ATOM 9092 CD2 LEU B 64 −79.904 −30.734 −18.737 1.00 15.30 C ATOM 9096 C LEU B 64 −75.975 −29.847 −16.966 1.00 17.39 C ATOM 9097 O LEU B 64 −76.370 −28.685 −16.825 1.00 17.38 O ATOM 9099 N GLY B 65 −74.848 −30.286 −16.432 1.00 16.73 N ATOM 9100 CA GLY B 65 −73.917 −29.374 −15.818 1.00 16.65 C ATOM 9103 C GLY B 65 −74.077 −29.249 −14.319 1.00 16.68 C ATOM 9104 O GLY B 65 −73.565 −28.302 −13.718 1.00 16.79 O ATOM 9106 N LEU B 66 −74.758 −30.209 −13.702 1.00 16.60 N ATOM 9107 CA LEU B 66 −74.978 −30.177 −12.264 1.00 16.58 C ATOM 9109 CB LEU B 66 −76.465 −30.389 −11.957 1.00 16.35 C ATOM 9112 CG LEU B 66 −77.363 −29.187 −12.234 1.00 15.57 C ATOM 9114 CD1 LEU B 66 −78.828 −29.602 −12.163 1.00 15.26 C ATOM 9118 CD2 LEU B 66 −77.063 −28.051 −11.270 1.00 13.66 C ATOM 9122 C LEU B 66 −74.129 −31.203 −11.513 1.00 16.94 C ATOM 9123 O LEU B 66 −74.152 −31.251 −10.279 1.00 17.50 O ATOM 9125 N GLY B 67 −73.373 −32.017 −12.236 1.00 17.03 N ATOM 9126 CA GLY B 67 −72.541 −33.036 −11.602 1.00 17.13 C ATOM 9129 C GLY B 67 −71.642 −32.557 −10.461 1.00 17.08 C ATOM 9130 O GLY B 67 −71.378 −33.317 −9.522 1.00 17.33 O ATOM 9132 N TYR B 68 −71.159 −31.316 −10.541 1.00 16.83 N ATOM 9133 CA TYR B 68 −70.217 −30.804 −9.552 1.00 16.64 C ATOM 9135 CB TYR B 68 −69.654 −29.437 −9.951 1.00 16.25 C ATOM 9138 CG TYR B 68 −70.609 −28.273 −9.802 1.00 13.51 C ATOM 9139 CD1 TYR B 68 −70.521 −27.411 −8.738 1.00 10.49 C ATOM 9141 CE1 TYR B 68 −71.407 −26.342 −8.608 1.00 10.25 C ATOM 9143 CZ TYR B 68 −72.382 −26.135 −9.555 1.00 9.74 C ATOM 9144 OH TYR B 68 −73.253 −25.086 −9.450 1.00 7.62 O ATOM 9146 CE2 TYR B 68 −72.484 −26.978 −10.625 1.00 11.14 C ATOM 9148 CD2 TYR B 68 −71.603 −28.037 −10.748 1.00 12.56 C ATOM 9150 C TYR B 68 −70.828 −30.700 −8.172 1.00 17.79 C ATOM 9151 O TYR B 68 −70.107 −30.811 −7.182 1.00 18.00 O ATOM 9153 N ARG B 69 −72.146 −30.485 −8.090 1.00 18.85 N ATOM 9154 CA ARG B 69 −72.784 −30.269 −6.789 1.00 19.46 C ATOM 9156 CB ARG B 69 −73.708 −29.047 −6.819 1.00 19.23 C ATOM 9159 CG ARG B 69 −75.030 −29.219 −7.509 1.00 18.83 C ATOM 9162 CD ARG B 69 −76.053 −28.192 −6.985 1.00 17.73 C ATOM 9165 NE ARG B 69 −75.642 −26.830 −7.297 1.00 16.01 N ATOM 9167 CZ ARG B 69 −75.330 −25.889 −6.417 1.00 14.68 C ATOM 9168 NH1 ARG B 69 −75.400 −26.093 −5.112 1.00 14.99 N ATOM 9171 NH2 ARG B 69 −74.959 −24.707 −6.861 1.00 15.04 N ATOM 9174 C ARG B 69 −73.490 −31.489 −6.234 1.00 20.50 C ATOM 9175 O ARG B 69 −74.084 −31.418 −5.163 1.00 20.67 O ATOM 9177 N PHE B 70 −73.416 −32.607 −6.959 1.00 22.04 N ATOM 9178 CA PHE B 70 −73.853 −33.917 −6.450 1.00 23.03 C ATOM 9180 CB PHE B 70 −75.081 −34.428 −7.211 1.00 22.94 C ATOM 9183 CG PHE B 70 −76.236 −33.503 −7.157 1.00 21.78 C ATOM 9184 CD1 PHE B 70 −77.024 −33.441 −6.028 1.00 20.54 C ATOM 9186 CE1 PHE B 70 −78.076 −32.571 −5.959 1.00 20.32 C ATOM 9188 CZ PHE B 70 −78.353 −31.752 −7.025 1.00 20.73 C ATOM 9190 CE2 PHE B 70 −77.564 −31.796 −8.160 1.00 21.24 C ATOM 9192 CD2 PHE B 70 −76.511 −32.665 −8.220 1.00 21.22 C ATOM 9194 C PHE B 70 −72.765 −34.962 −6.570 1.00 24.33 C ATOM 9195 O PHE B 70 −73.069 −36.142 −6.614 1.00 24.56 O ATOM 9197 N GLU B 71 −71.500 −34.547 −6.624 1.00 26.01 N ATOM 9198 CA GLU B 71 −70.413 −35.506 −6.804 1.00 27.04 C ATOM 9200 CB GLU B 71 −69.042 −34.824 −6.885 1.00 27.48 C ATOM 9203 CG GLU B 71 −67.851 −35.816 −6.794 1.00 28.94 C ATOM 9206 CD GLU B 71 −66.491 −35.192 −7.081 1.00 30.38 C ATOM 9207 OE1 GLU B 71 −66.398 −34.192 −7.835 1.00 30.52 O ATOM 9208 OE2 GLU B 71 −65.501 −35.730 −6.544 1.00 32.16 O ATOM 9209 C GLU B 71 −70.436 −36.531 −5.680 1.00 27.46 C ATOM 9210 O GLU B 71 −70.449 −37.723 −5.937 1.00 27.67 O ATOM 9212 N SER B 72 −70.464 −36.087 −4.435 1.00 28.04 N ATOM 9213 CA SER B 72 −70.381 −37.044 −3.348 1.00 28.86 C ATOM 9215 CB SER B 72 −70.388 −36.340 −1.983 1.00 29.09 C ATOM 9218 OG SER B 72 −71.649 −35.751 −1.687 1.00 30.21 O ATOM 9220 C SER B 72 −71.519 −38.058 −3.481 1.00 29.30 C ATOM 9221 O SER B 72 −71.304 −39.265 −3.384 1.00 29.24 O ATOM 9223 N ASP B 73 −72.719 −37.560 −3.756 1.00 30.03 N ATOM 9224 CA ASP B 73 −73.897 −38.417 −3.874 1.00 30.63 C ATOM 9226 CB ASP B 73 −75.184 −37.598 −4.116 1.00 30.74 C ATOM 9229 CG ASP B 73 −75.419 −36.509 −3.052 1.00 31.84 C ATOM 9230 OD1 ASP B 73 −75.562 −36.830 −1.841 1.00 31.70 O ATOM 9231 OD2 ASP B 73 −75.473 −35.317 −3.443 1.00 33.81 O ATOM 9232 C ASP B 73 −73.722 −39.443 −4.994 1.00 30.81 C ATOM 9233 O ASP B 73 −74.130 −40.590 −4.835 1.00 31.39 O ATOM 9235 N ILE B 74 −73.122 −39.031 −6.112 1.00 30.96 N ATOM 9236 CA ILE B 74 −72.917 −39.912 −7.282 1.00 31.04 C ATOM 9238 CB ILE B 74 −72.461 −39.114 −8.524 1.00 30.88 C ATOM 9240 CG1 ILE B 74 −73.585 −38.213 −9.018 1.00 30.99 C ATOM 9243 CD1 ILE B 74 −73.105 −37.120 −9.923 1.00 31.54 C ATOM 9247 CG2 ILE B 74 −72.052 −40.035 −9.642 1.00 29.85 C ATOM 9251 C ILE B 74 −71.885 −41.005 −6.999 1.00 31.45 C ATOM 9252 O ILE B 74 −72.098 −42.165 −7.347 1.00 31.31 O ATOM 9254 N ARG B 75 −70.768 −40.628 −6.380 1.00 31.93 N ATOM 9255 CA ARG B 75 −69.778 −41.601 −5.947 1.00 32.38 C ATOM 9257 CB ARG B 75 −68.629 −40.959 −5.137 1.00 32.87 C ATOM 9260 CG ARG B 75 −67.310 −40.751 −5.915 1.00 35.01 C ATOM 9263 CD ARG B 75 −66.089 −40.489 −5.003 1.00 37.62 C ATOM 9266 NE ARG B 75 −65.260 −41.687 −4.783 1.00 41.03 N ATOM 9268 CZ ARG B 75 −64.461 −42.253 −5.700 1.00 44.29 C ATOM 9269 NH1 ARG B 75 −64.385 −41.751 −6.931 1.00 46.22 N ATOM 9272 NH2 ARG B 75 −63.741 −43.341 −5.404 1.00 44.30 N ATOM 9275 C ARG B 75 −70.478 −42.673 −5.126 1.00 32.18 C ATOM 9276 O ARG B 75 −70.307 −43.849 −5.398 1.00 32.19 O ATOM 9278 N ARG B 76 −71.280 −42.275 −4.143 1.00 32.21 N ATOM 9279 CA ARG B 76 −71.975 −43.256 −3.307 1.00 32.61 C ATOM 9281 CB ARG B 76 −72.737 −42.582 −2.162 1.00 32.75 C ATOM 9284 CG ARG B 76 −71.880 −42.320 −.929 1.00 33.44 C ATOM 9287 CD ARG B 76 −72.720 −42.046 .334 1.00 34.16 C ATOM 9290 NE ARG B 76 −73.797 −41.074 .124 1.00 34.53 N ATOM 9292 CZ ARG B 76 −73.627 −39.765 −.063 1.00 34.38 C ATOM 9293 NH1 ARG B 76 −72.414 −39.219 −.092 1.00 34.34 N ATOM 9296 NH2 ARG B 76 −74.689 −38.993 −.241 1.00 34.71 N ATOM 9299 C ARG B 76 −72.918 −44.159 −4.112 1.00 32.81 C ATOM 9300 O ARG B 76 −72.863 −45.379 −3.995 1.00 32.86 O ATOM 9302 N ALA B 77 −73.780 −43.559 −4.923 1.00 33.10 N ATOM 9303 CA ALA B 77 −74.655 −44.307 −5.813 1.00 33.27 C ATOM 9305 CB ALA B 77 −75.321 −43.366 −6.770 1.00 33.26 C ATOM 9309 C ALA B 77 −73.884 −45.370 −6.578 1.00 33.80 C ATOM 9310 O ALA B 77 −74.235 −46.542 −6.559 1.00 33.75 O ATOM 9312 N LEU B 78 −72.816 −44.952 −7.242 1.00 34.77 N ATOM 9313 CA LEU B 78 −71.987 −45.868 −8.019 1.00 35.41 C ATOM 9315 CB LEU B 78 −70.845 −45.109 −8.702 1.00 35.01 C ATOM 9318 CG LEU B 78 −71.220 −44.092 −9.782 1.00 34.37 C ATOM 9320 CD1 LEU B 78 −69.945 −43.502 −10.381 1.00 33.93 C ATOM 9324 CD2 LEU B 78 −72.109 −44.692 −10.873 1.00 32.94 C ATOM 9328 C LEU B 78 −71.409 −46.974 −7.142 1.00 36.50 C ATOM 9329 O LEU B 78 −71.336 −48.124 −7.552 1.00 36.87 O ATOM 9331 N ASP B 79 −71.005 −46.619 −5.931 1.00 37.74 N ATOM 9332 CA ASP B 79 −70.308 −47.545 −5.056 1.00 38.74 C ATOM 9334 CB ASP B 79 −69.787 −46.810 −3.819 1.00 38.99 C ATOM 9337 CG ASP B 79 −68.499 −47.386 −3.313 1.00 40.08 C ATOM 9338 OD1 ASP B 79 −68.494 −48.591 −2.976 1.00 42.32 O ATOM 9339 OD2 ASP B 79 −67.494 −46.638 −3.261 1.00 41.24 O ATOM 9340 C ASP B 79 −71.207 −48.705 −4.645 1.00 39.42 C ATOM 9341 O ASP B 79 −70.736 −49.835 −4.505 1.00 39.58 O ATOM 9343 N ARG B 80 −72.495 −48.424 −4.450 1.00 40.26 N ATOM 9344 CA ARG B 80 −73.471 −49.470 −4.143 1.00 40.92 C ATOM 9346 CB ARG B 80 −74.823 −48.881 −3.716 1.00 41.46 C ATOM 9349 CG ARG B 80 −74.871 −48.247 −2.308 1.00 42.87 C ATOM 9352 CD ARG B 80 −76.316 −47.826 −1.936 1.00 44.62 C ATOM 9355 NE ARG B 80 −76.946 −46.968 −2.949 1.00 45.87 N ATOM 9357 CZ ARG B 80 −76.741 −45.651 −3.089 1.00 46.82 C ATOM 9358 NH1 ARG B 80 −75.905 −44.989 −2.282 1.00 46.27 N ATOM 9361 NH2 ARG B 80 −77.378 −44.988 −4.059 1.00 47.22 N ATOM 9364 C ARG B 80 −73.667 −50.341 −5.371 1.00 40.77 C ATOM 9365 O ARG B 80 −73.642 −51.563 −5.275 1.00 41.06 O ATOM 9367 N PHE B 81 −73.863 −49.705 −6.520 1.00 40.56 N ATOM 9368 CA PHE B 81 −73.986 −50.418 −7.787 1.00 40.59 C ATOM 9370 CB PHE B 81 −73.984 −49.426 −8.956 1.00 40.73 C ATOM 9373 CG PHE B 81 −73.898 −50.063 −10.323 1.00 40.84 C ATOM 9374 CD1 PHE B 81 −75.000 −50.668 −10.893 1.00 41.39 C ATOM 9376 CE1 PHE B 81 −74.925 −51.236 −12.167 1.00 41.67 C ATOM 9378 CZ PHE B 81 −73.741 −51.191 −12.877 1.00 41.33 C ATOM 9380 CE2 PHE B 81 −72.638 −50.580 −12.326 1.00 41.19 C ATOM 9382 CD2 PHE B 81 −72.720 −50.012 −11.057 1.00 41.39 C ATOM 9384 C PHE B 81 −72.871 −51.441 −7.953 1.00 40.47 C ATOM 9385 O PHE B 81 −73.134 −52.583 −8.311 1.00 40.85 O ATOM 9387 N VAL B 82 −71.633 −51.051 −7.683 1.00 40.26 N ATOM 9388 CA VAL B 82 −70.522 −51.986 −7.821 1.00 40.24 C ATOM 9390 CB VAL B 82 −69.173 −51.386 −7.379 1.00 40.28 C ATOM 9392 CG1 VAL B 82 −68.164 −52.493 −7.063 1.00 39.98 C ATOM 9396 CG2 VAL B 82 −68.644 −50.462 −8.451 1.00 40.09 C ATOM 9400 C VAL B 82 −70.788 −53.230 −7.005 1.00 40.16 C ATOM 9401 O VAL B 82 −70.880 −54.313 −7.559 1.00 40.13 O ATOM 9403 N SER B 83 −70.953 −53.056 −5.698 1.00 40.26 N ATOM 9404 CA SER B 83 −71.070 −54.174 −4.749 1.00 40.43 C ATOM 9406 CB SER B 83 −70.797 −53.666 −3.331 1.00 40.54 C ATOM 9409 OG SER B 83 −71.256 −52.330 −3.191 1.00 40.89 O ATOM 9411 C SER B 83 −72.415 −54.912 −4.831 1.00 40.34 C ATOM 9412 O SER B 83 −73.137 −55.046 −3.845 1.00 39.99 O ATOM 9414 N SER B 84 −72.698 −55.400 −6.038 1.00 40.57 N ATOM 9415 CA SER B 84 −73.902 −56.154 −6.411 1.00 40.63 C ATOM 9417 CB SER B 84 −75.154 −55.679 −5.651 1.00 40.56 C ATOM 9420 OG SER B 84 −75.292 −54.268 −5.663 1.00 39.82 O ATOM 9422 C SER B 84 −74.104 −56.026 −7.940 1.00 40.85 C ATOM 9423 O SER B 84 −75.104 −55.462 −8.395 1.00 41.24 O ATOM 9425 N GLY B 85 −73.136 −56.524 −8.720 1.00 40.75 N ATOM 9426 CA GLY B 85 −73.201 −56.506 −10.191 1.00 40.64 C ATOM 9429 C GLY B 85 −73.225 −55.120 −10.815 1.00 40.64 C ATOM 9430 O GLY B 85 −74.133 −54.794 −11.590 1.00 40.32 O ATOM 9432 N THR B 93 −74.847 −57.360 −18.759 1.00 36.30 N ATOM 9433 CA THR B 93 −75.593 −58.129 −19.774 1.00 35.99 C ATOM 9435 CB THR B 93 −76.251 −59.379 −19.152 1.00 35.87 C ATOM 9437 OG1 THR B 93 −76.347 −60.389 −20.158 1.00 35.64 O ATOM 9439 CG2 THR B 93 −77.646 −59.062 −18.548 1.00 34.95 C ATOM 9443 C THR B 93 −76.625 −57.274 −20.583 1.00 35.90 C ATOM 9444 O THR B 93 −77.764 −57.688 −20.843 1.00 35.74 O ATOM 9446 N SER B 94 −76.175 −56.076 −20.963 1.00 35.58 N ATOM 9447 CA SER B 94 −76.874 −55.150 −21.866 1.00 34.97 C ATOM 9449 CB SER B 94 −78.074 −54.472 −21.190 1.00 35.06 C ATOM 9452 OG SER B 94 −77.702 −53.260 −20.541 1.00 34.37 O ATOM 9454 C SER B 94 −75.831 −54.097 −22.232 1.00 34.39 C ATOM 9455 O SER B 94 −75.212 −53.518 −21.341 1.00 34.11 O ATOM 9457 N LEU B 95 −75.619 −53.864 −23.522 1.00 33.77 N ATOM 9458 CA LEU B 95 −74.490 −53.045 −23.952 1.00 33.33 C ATOM 9460 CB LEU B 95 −74.373 −53.010 −25.475 1.00 33.30 C ATOM 9463 CG LEU B 95 −73.154 −52.246 −26.006 1.00 33.27 C ATOM 9465 CD1 LEU B 95 −71.909 −52.455 −25.137 1.00 32.89 C ATOM 9469 CD2 LEU B 95 −72.864 −52.649 −27.438 1.00 33.19 C ATOM 9473 C LEU B 95 −74.551 −51.623 −23.413 1.00 33.00 C ATOM 9474 O LEU B 95 −73.588 −51.151 −22.809 1.00 32.83 O ATOM 9476 N HIS B 96 −75.678 −50.949 −23.633 1.00 32.64 N ATOM 9477 CA HIS B 96 −75.853 −49.576 −23.171 1.00 32.39 C ATOM 9479 CB HIS B 96 −77.246 −49.069 −23.527 1.00 32.64 C ATOM 9482 CG HIS B 96 −77.528 −47.689 −23.025 1.00 34.16 C ATOM 9483 ND1 HIS B 96 −76.565 −46.703 −22.981 1.00 36.21 N ATOM 9485 CE1 HIS B 96 −77.096 −45.594 −22.496 1.00 36.92 C ATOM 9487 NE2 HIS B 96 −78.371 −45.827 −22.227 1.00 37.06 N ATOM 9489 CD2 HIS B 96 −78.664 −47.130 −22.548 1.00 35.43 C ATOM 9491 C HIS B 96 −75.612 −49.445 −21.665 1.00 31.78 C ATOM 9492 O HIS B 96 −74.936 −48.523 −21.215 1.00 31.95 O ATOM 9494 N GLY B 97 −76.156 −50.372 −20.887 1.00 31.10 N ATOM 9495 CA GLY B 97 −75.907 −50.396 −19.446 1.00 30.52 C ATOM 9498 C GLY B 97 −74.434 −50.532 −19.085 1.00 29.95 C ATOM 9499 O GLY B 97 −73.936 −49.797 −18.241 1.00 30.21 O ATOM 9501 N THR B 98 −73.740 −51.470 −19.726 1.00 29.15 N ATOM 9502 CA THR B 98 −72.314 −51.690 −19.490 1.00 28.55 C ATOM 9504 CB THR B 98 −71.803 −52.955 −20.248 1.00 28.48 C ATOM 9506 OG1 THR B 98 −72.678 −54.066 −19.997 1.00 28.41 O ATOM 9508 CG2 THR B 98 −70.405 −53.331 −19.816 1.00 27.74 C ATOM 9512 C THR B 98 −71.492 −50.452 −19.894 1.00 28.31 C ATOM 9513 O THR B 98 −70.658 −49.979 −19.127 1.00 28.13 O ATOM 9515 N ALA B 99 −71.750 −49.910 −21.080 1.00 28.04 N ATOM 9516 CA ALA B 99 −70.984 −48.758 −21.578 1.00 27.88 C ATOM 9518 CB ALA B 99 −71.387 −48.406 −23.014 1.00 27.78 C ATOM 9522 C ALA B 99 −71.127 −47.538 −20.684 1.00 27.62 C ATOM 9523 O ALA B 99 −70.135 −46.885 −20.361 1.00 27.84 O ATOM 9525 N LEU B 100 −72.357 −47.233 −20.290 1.00 27.20 N ATOM 9526 CA LEU B 100 −72.613 −46.088 −19.422 1.00 27.08 C ATOM 9528 CB LEU B 100 −74.122 −45.900 −19.230 1.00 26.95 C ATOM 9531 CG LEU B 100 −74.560 −44.715 −18.367 1.00 26.27 C ATOM 9533 CD1 LEU B 100 −73.753 −43.478 −18.734 1.00 26.19 C ATOM 9537 CD2 LEU B 100 −76.052 −44.445 −18.504 1.00 25.20 C ATOM 9541 C LEU B 100 −71.928 −46.221 −18.046 1.00 27.23 C ATOM 9542 O LEU B 100 −71.368 −45.243 −17.523 1.00 27.16 O ATOM 9544 N SER B 101 −71.980 −47.429 −17.472 1.00 27.00 N ATOM 9545 CA SER B 101 −71.475 −47.682 −16.117 1.00 26.63 C ATOM 9547 CB SER B 101 −72.039 −48.992 −15.568 1.00 26.49 C ATOM 9550 OG SER B 101 −71.758 −50.063 −16.442 1.00 26.38 O ATOM 9552 C SER B 101 −69.956 −47.740 −16.090 1.00 26.47 C ATOM 9553 O SER B 101 −69.326 −47.324 −15.121 1.00 26.35 O ATOM 9555 N PHE B 102 −69.381 −48.288 −17.154 1.00 26.29 N ATOM 9556 CA PHE B 102 −67.934 −48.332 −17.322 1.00 25.91 C ATOM 9558 CB PHE B 102 −67.588 −49.005 −18.652 1.00 25.96 C ATOM 9561 CG PHE B 102 −66.133 −49.020 −18.958 1.00 25.81 C ATOM 9562 CD1 PHE B 102 −65.360 −50.115 −18.633 1.00 25.96 C ATOM 9564 CE1 PHE B 102 −63.999 −50.122 −18.909 1.00 26.94 C ATOM 9566 CZ PHE B 102 −63.403 −49.026 −19.519 1.00 26.27 C ATOM 9568 CE2 PHE B 102 −64.174 −47.930 −19.848 1.00 26.19 C ATOM 9570 CD2 PHE B 102 −65.531 −47.933 −19.573 1.00 26.04 C ATOM 9572 C PHE B 102 −67.416 −46.911 −17.315 1.00 25.56 C ATOM 9573 O PHE B 102 −66.486 −46.564 −16.568 1.00 25.37 O ATOM 9575 N ARG B 103 −68.050 −46.095 −18.152 1.00 25.20 N ATOM 9576 CA ARG B 103 −67.663 −44.696 −18.322 1.00 25.09 C ATOM 9578 CB ARG B 103 −68.510 −44.026 −19.400 1.00 25.12 C ATOM 9581 CG ARG B 103 −68.194 −42.561 −19.572 1.00 25.41 C ATOM 9584 CD ARG B 103 −68.744 −42.035 −20.889 1.00 26.68 C ATOM 9587 NE ARG B 103 −70.197 −41.843 −20.877 1.00 27.49 N ATOM 9589 CZ ARG B 103 −70.826 −40.851 −20.246 1.00 26.56 C ATOM 9590 NH1 ARG B 103 −70.139 −39.963 −19.531 1.00 27.11 N ATOM 9593 NH2 ARG B 103 −72.148 −40.759 −20.310 1.00 25.20 N ATOM 9596 C ARG B 103 −67.785 −43.898 −17.033 1.00 24.61 C ATOM 9597 O ARG B 103 −66.865 −43.168 −16.659 1.00 24.67 O ATOM 9599 N LEU B 104 −68.927 −44.013 −16.371 1.00 23.79 N ATOM 9600 CA LEU B 104 −69.125 −43.263 −15.148 1.00 23.23 C ATOM 9602 CB LEU B 104 −70.591 −43.342 −14.693 1.00 23.01 C ATOM 9605 CG LEU B 104 −71.607 −42.620 −15.584 1.00 21.36 C ATOM 9607 CD1 LEU B 104 −73.002 −42.860 −15.067 1.00 19.31 C ATOM 9611 CD2 LEU B 104 −71.310 −41.157 −15.633 1.00 19.57 C ATOM 9615 C LEU B 104 −68.156 −43.781 −14.071 1.00 23.15 C ATOM 9616 O LEU B 104 −67.445 −43.007 −13.423 1.00 23.40 O ATOM 9618 N LEU B 105 −68.106 −45.091 −13.894 1.00 22.79 N ATOM 9619 CA LEU B 105 −67.203 −45.659 −12.916 1.00 22.40 C ATOM 9621 CB LEU B 105 −67.303 −47.178 −12.912 1.00 22.42 C ATOM 9624 CG LEU B 105 −68.505 −47.709 −12.163 1.00 21.82 C ATOM 9626 CD1 LEU B 105 −68.810 −49.120 −12.591 1.00 21.95 C ATOM 9630 CD2 LEU B 105 −68.201 −47.648 −10.692 1.00 22.14 C ATOM 9634 C LEU B 105 −65.767 −45.239 −13.196 1.00 22.33 C ATOM 9635 O LEU B 105 −65.049 −44.823 −12.275 1.00 22.13 O ATOM 9637 N ARG B 106 −65.331 −45.342 −14.451 1.00 22.08 N ATOM 9638 CA ARG B 106 −63.953 −44.973 −14.730 1.00 22.20 C ATOM 9640 CB ARG B 106 −63.521 −45.266 −16.151 1.00 22.33 C ATOM 9643 CG ARG B 106 −62.075 −44.827 −16.329 1.00 23.60 C ATOM 9646 CD ARG B 106 −61.383 −45.445 −17.513 1.00 24.71 C ATOM 9649 NE ARG B 106 −61.078 −46.852 −17.319 1.00 24.66 N ATOM 9651 CZ ARG B 106 −60.418 −47.582 −18.206 1.00 25.75 C ATOM 9652 NH1 ARG B 106 −59.995 −47.028 −19.337 1.00 26.41 N ATOM 9655 NH2 ARG B 106 −60.182 −48.866 −17.971 1.00 26.54 N ATOM 9658 C ARG B 106 −63.732 −43.504 −14.438 1.00 21.75 C ATOM 9659 O ARG B 106 −62.801 −43.145 −13.725 1.00 21.50 O ATOM 9661 N GLN B 107 −64.609 −42.680 −15.003 1.00 21.69 N ATOM 9662 CA GLN B 107 −64.630 −41.239 −14.794 1.00 21.64 C ATOM 9664 CB GLN B 107 −65.964 −40.664 −15.261 1.00 21.71 C ATOM 9667 CG GLN B 107 −66.169 −39.178 −14.929 1.00 21.97 C ATOM 9670 CD GLN B 107 −67.588 −38.723 −15.172 1.00 21.54 C ATOM 9671 OE1 GLN B 107 −68.355 −39.365 −15.906 1.00 20.08 O ATOM 9672 NE2 GLN B 107 −67.948 −37.600 −14.556 1.00 21.45 N ATOM 9675 C GLN B 107 −64.454 −40.850 −13.352 1.00 21.70 C ATOM 9676 O GLN B 107 −63.776 −39.865 −13.078 1.00 22.14 O ATOM 9678 N HIS B 108 −65.091 −41.599 −12.450 1.00 21.53 N ATOM 9679 CA HIS B 108 −65.049 −41.326 −11.019 1.00 21.63 C ATOM 9681 CB HIS B 108 −66.447 −41.535 −10.429 1.00 21.47 C ATOM 9684 CG HIS B 108 −67.416 −40.445 −10.752 1.00 20.91 C ATOM 9685 ND1 HIS B 108 −67.541 −39.315 −9.976 1.00 20.66 N ATOM 9687 CE1 HIS B 108 −68.476 −38.535 −10.490 1.00 20.90 C ATOM 9689 NE2 HIS B 108 −68.966 −39.118 −11.567 1.00 19.67 N ATOM 9691 CD2 HIS B 108 −68.326 −40.320 −11.747 1.00 20.76 C ATOM 9693 C HIS B 108 −64.024 −42.209 −10.269 1.00 22.22 C ATOM 9694 O HIS B 108 −64.220 −42.553 −9.104 1.00 22.17 O ATOM 9696 N GLY B 109 −62.950 −42.613 −10.933 1.00 22.91 N ATOM 9697 CA GLY B 109 −61.846 −43.288 −10.245 1.00 23.85 C ATOM 9700 C GLY B 109 −61.986 −44.748 −9.800 1.00 24.50 C ATOM 9701 O GLY B 109 −61.053 −45.306 −9.189 1.00 24.12 O ATOM 9703 N PHE B 110 −63.128 −45.371 −10.094 1.00 25.16 N ATOM 9704 CA PHE B 110 −63.309 −46.791 −9.800 1.00 25.67 C ATOM 9706 CB PHE B 110 −64.782 −47.187 −9.891 1.00 25.80 C ATOM 9709 CG PHE B 110 −65.625 −46.656 −8.772 1.00 26.12 C ATOM 9710 CD1 PHE B 110 −65.564 −47.230 −7.510 1.00 27.13 C ATOM 9712 CE1 PHE B 110 −66.353 −46.751 −6.468 1.00 27.42 C ATOM 9714 CZ PHE B 110 −67.215 −45.691 −6.692 1.00 26.93 C ATOM 9716 CE2 PHE B 110 −67.284 −45.119 −7.954 1.00 26.49 C ATOM 9718 CD2 PHE B 110 −66.494 −45.601 −8.981 1.00 25.96 C ATOM 9720 C PHE B 110 −62.505 −47.615 −10.793 1.00 25.92 C ATOM 9721 O PHE B 110 −62.232 −47.157 −11.898 1.00 26.41 O ATOM 9723 N GLU B 111 −62.134 −48.832 −10.406 1.00 26.06 N ATOM 9724 CA GLU B 111 −61.403 −49.724 −11.304 1.00 26.17 C ATOM 9726 CB GLU B 111 −60.444 −50.609 −10.511 1.00 26.50 C ATOM 9729 CG GLU B 111 −59.372 −51.272 −11.374 1.00 28.11 C ATOM 9732 CD GLU B 111 −58.607 −52.377 −10.646 1.00 30.70 C ATOM 9733 OE1 GLU B 111 −58.660 −52.436 −9.390 1.00 31.99 O ATOM 9734 OE2 GLU B 111 −57.948 −53.190 −11.338 1.00 32.09 O ATOM 9735 C GLU B 111 −62.355 −50.598 −12.130 1.00 25.60 C ATOM 9736 O GLU B 111 −63.116 −51.388 −11.585 1.00 25.48 O ATOM 9738 N VAL B 112 −62.314 −50.439 −13.447 1.00 25.24 N ATOM 9739 CA VAL B 112 −63.026 −51.331 −14.357 1.00 24.90 C ATOM 9741 CB VAL B 112 −64.308 −50.712 −14.908 1.00 24.92 C ATOM 9743 CG1 VAL B 112 −65.268 −50.437 −13.771 1.00 25.26 C ATOM 9747 CG2 VAL B 112 −63.999 −49.450 −15.706 1.00 24.77 C ATOM 9751 C VAL B 112 −62.144 −51.701 −15.522 1.00 24.66 C ATOM 9752 O VAL B 112 −61.217 −50.964 −15.862 1.00 23.80 O ATOM 9754 N SER B 113 −62.467 −52.842 −16.132 1.00 24.88 N ATOM 9755 CA SER B 113 −61.604 −53.494 −17.109 1.00 25.21 C ATOM 9757 CB SER B 113 −61.286 −54.913 −16.654 1.00 24.94 C ATOM 9760 OG SER B 113 −60.357 −55.523 −17.528 1.00 24.31 O ATOM 9762 C SER B 113 −62.233 −53.532 −18.492 1.00 25.88 C ATOM 9763 O SER B 113 −63.446 −53.651 −18.630 1.00 25.86 O ATOM 9765 N GLN B 114 −61.406 −53.438 −19.526 1.00 26.92 N ATOM 9766 CA GLN B 114 −61.928 −53.491 −20.880 1.00 27.83 C ATOM 9768 CB GLN B 114 −60.846 −53.194 −21.917 1.00 27.75 C ATOM 9771 CG GLN B 114 −59.559 −53.952 −21.726 1.00 28.05 C ATOM 9774 CD GLN B 114 −58.739 −54.077 −23.007 1.00 28.39 C ATOM 9775 OE1 GLN B 114 −59.086 −53.515 −24.051 1.00 29.05 O ATOM 9776 NE2 GLN B 114 −57.637 −54.808 −22.925 1.00 27.62 N ATOM 9779 C GLN B 114 −62.615 −54.827 −21.158 1.00 28.78 C ATOM 9780 O GLN B 114 −63.484 −54.905 −22.022 1.00 29.10 O ATOM 9782 N GLU B 115 −62.248 −55.861 −20.401 1.00 29.99 N ATOM 9783 CA GLU B 115 −62.888 −57.181 −20.505 1.00 30.89 C ATOM 9785 CB GLU B 115 −62.252 −58.202 −19.549 1.00 31.10 C ATOM 9788 CG GLU B 115 −60.740 −58.394 −19.697 1.00 32.35 C ATOM 9791 CD GLU B 115 −60.320 −58.796 −21.106 1.00 34.20 C ATOM 9792 OE1 GLU B 115 −60.965 −59.699 −21.688 1.00 34.94 O ATOM 9793 OE2 GLU B 115 −59.348 −58.201 −21.634 1.00 35.60 O ATOM 9794 C GLU B 115 −64.380 −57.120 −20.224 1.00 31.26 C ATOM 9795 O GLU B 115 −65.125 −57.971 −20.691 1.00 31.54 O ATOM 9797 N ALA B 116 −64.825 −56.127 −19.465 1.00 31.91 N ATOM 9798 CA ALA B 116 −66.255 −55.937 −19.259 1.00 32.69 C ATOM 9800 CB ALA B 116 −66.521 −54.648 −18.513 1.00 32.62 C ATOM 9804 C ALA B 116 −66.999 −55.950 −20.597 1.00 33.33 C ATOM 9805 O ALA B 116 −68.156 −56.364 −20.668 1.00 33.26 O ATOM 9807 N PHE B 117 −66.316 −55.521 −21.655 1.00 34.16 N ATOM 9808 CA PHE B 117 −66.889 −55.498 −22.996 1.00 34.98 C ATOM 9810 CB PHE B 117 −66.310 −54.314 −23.766 1.00 35.02 C ATOM 9813 CG PHE B 117 −66.868 −52.997 −23.345 1.00 35.06 C ATOM 9814 CD1 PHE B 117 −66.061 −52.046 −22.729 1.00 35.33 C ATOM 9816 CE1 PHE B 117 −66.576 −50.825 −22.342 1.00 35.16 C ATOM 9818 CZ PHE B 117 −67.907 −50.544 −22.570 1.00 35.37 C ATOM 9820 CE2 PHE B 117 −68.723 −51.488 −23.187 1.00 35.28 C ATOM 9822 CD2 PHE B 117 −68.201 −52.701 −23.571 1.00 34.68 C ATOM 9824 C PHE B 117 −66.676 −56.766 −23.830 1.00 35.86 C ATOM 9825 O PHE B 117 −66.934 −56.755 −25.037 1.00 35.91 O ATOM 9827 N SER B 118 −66.215 −57.853 −23.212 1.00 36.98 N ATOM 9828 CA SER B 118 −65.924 −59.086 −23.960 1.00 37.76 C ATOM 9830 CB SER B 118 −64.836 −59.907 −23.262 1.00 37.73 C ATOM 9833 OG SER B 118 −65.272 −60.346 −21.987 1.00 37.77 O ATOM 9835 C SER B 118 −67.178 −59.939 −24.215 1.00 38.48 C ATOM 9836 O SER B 118 −67.207 −60.724 −25.157 1.00 38.42 O ATOM 9838 N GLY B 119 −68.221 −59.765 −23.407 1.00 39.51 N ATOM 9839 CA GLY B 119 −69.481 −60.473 −23.629 1.00 40.51 C ATOM 9842 C GLY B 119 −70.287 −60.034 −24.848 1.00 41.51 C ATOM 9843 O GLY B 119 −71.444 −60.433 −25.002 1.00 41.53 O ATOM 9845 N PHE B 120 −69.688 −59.210 −25.709 1.00 42.79 N ATOM 9846 CA PHE B 120 −70.382 −58.621 −26.864 1.00 43.81 C ATOM 9848 CB PHE B 120 −70.643 −57.121 −26.601 1.00 43.76 C ATOM 9851 CG PHE B 120 −71.367 −56.853 −25.293 1.00 43.65 C ATOM 9852 CD1 PHE B 120 −72.762 −56.874 −25.230 1.00 43.48 C ATOM 9854 CE1 PHE B 120 −73.437 −56.650 −24.023 1.00 43.03 C ATOM 9856 CZ PHE B 120 −72.717 −56.413 −22.865 1.00 43.09 C ATOM 9858 CE2 PHE B 120 −71.323 −56.397 −22.909 1.00 43.38 C ATOM 9860 CD2 PHE B 120 −70.655 −56.619 −24.120 1.00 43.41 C ATOM 9862 C PHE B 120 −69.607 −58.832 −28.175 1.00 44.81 C ATOM 9863 O PHE B 120 −69.930 −58.238 −29.205 1.00 44.65 O ATOM 9865 N LYS B 121 −68.602 −59.705 −28.126 1.00 46.19 N ATOM 9866 CA LYS B 121 −67.757 −60.004 −29.272 1.00 47.31 C ATOM 9868 CB LYS B 121 −66.275 −59.928 −28.870 1.00 47.47 C ATOM 9871 CG LYS B 121 −65.743 −58.495 −28.637 1.00 48.13 C ATOM 9874 CD LYS B 121 −64.532 −58.439 −27.675 1.00 48.89 C ATOM 9877 CE LYS B 121 −63.261 −59.094 −28.241 1.00 49.20 C ATOM 9880 NZ LYS B 121 −62.541 −58.232 −29.218 1.00 49.04 N ATOM 9884 C LYS B 121 −68.096 −61.400 −29.810 1.00 48.15 C ATOM 9885 O LYS B 121 −68.199 −62.361 −29.043 1.00 48.36 O ATOM 9887 N ASP B 122 −68.270 −61.510 −31.126 1.00 49.04 N ATOM 9888 CA ASP B 122 −68.611 −62.788 −31.754 1.00 49.60 C ATOM 9890 CB ASP B 122 −69.070 −62.596 −33.217 1.00 49.52 C ATOM 9893 CG ASP B 122 −67.989 −62.015 −34.126 1.00 49.18 C ATOM 9894 OD1 ASP B 122 −66.792 −62.306 −33.938 1.00 48.96 O ATOM 9895 OD2 ASP B 122 −68.351 −61.268 −35.057 1.00 48.82 O ATOM 9896 C ASP B 122 −67.455 −63.785 −31.651 1.00 50.31 C ATOM 9897 O ASP B 122 −66.369 −63.441 −31.171 1.00 50.33 O ATOM 9899 N GLN B 123 −67.705 −65.014 −32.098 1.00 51.05 N ATOM 9900 CA GLN B 123 −66.716 −66.095 −32.057 1.00 51.61 C ATOM 9902 CB GLN B 123 −67.263 −67.330 −32.785 1.00 51.82 C ATOM 9905 CG GLN B 123 −68.483 −67.986 −32.117 1.00 52.32 C ATOM 9908 CD GLN B 123 −68.117 −69.137 −31.184 1.00 52.64 C ATOM 9909 OE1 GLN B 123 −67.146 −69.062 −30.432 1.00 53.02 O ATOM 9910 NE2 GLN B 123 −68.904 −70.207 −31.230 1.00 52.04 N ATOM 9913 C GLN B 123 −65.358 −65.694 −32.659 1.00 51.78 C ATOM 9914 O GLN B 123 −64.309 −66.000 −32.090 1.00 51.67 O ATOM 9916 N ASN B 124 −65.388 −65.004 −33.799 1.00 52.05 N ATOM 9917 CA ASN B 124 −64.166 −64.547 −34.473 1.00 52.25 C ATOM 9919 CB ASN B 124 −64.486 −64.042 −35.884 1.00 52.25 C ATOM 9922 CG ASN B 124 −64.911 −65.158 −36.819 1.00 51.88 C ATOM 9923 OD1 ASN B 124 −65.918 −65.825 −36.592 1.00 51.43 O ATOM 9924 ND2 ASN B 124 −64.144 −65.364 −37.880 1.00 51.23 N ATOM 9927 C ASN B 124 −63.382 −63.466 −33.716 1.00 52.43 C ATOM 9928 O ASN B 124 −62.189 −63.287 −33.959 1.00 52.33 O ATOM 9930 N GLY B 125 −64.051 −62.747 −32.815 1.00 52.66 N ATOM 9931 CA GLY B 125 −63.396 −61.745 −31.968 1.00 52.68 C ATOM 9934 C GLY B 125 −63.916 −60.329 −32.135 1.00 52.63 C ATOM 9935 O GLY B 125 −63.539 −59.447 −31.367 1.00 52.57 O ATOM 9937 N ASN B 126 −64.782 −60.117 −33.129 1.00 52.54 N ATOM 9938 CA ASN B 126 −65.343 −58.793 −33.443 1.00 52.41 C ATOM 9940 CB ASN B 126 −65.575 −58.671 −34.949 1.00 52.40 C ATOM 9943 CG ASN B 126 −64.322 −58.951 −35.751 1.00 52.64 C ATOM 9944 OD1 ASN B 126 −63.426 −59.665 −35.297 1.00 52.77 O ATOM 9945 ND2 ASN B 126 −64.249 −58.390 −36.952 1.00 53.00 N ATOM 9948 C ASN B 126 −66.656 −58.524 −32.712 1.00 52.10 C ATOM 9949 O ASN B 126 −67.253 −59.432 −32.153 1.00 52.27 O ATOM 9951 N PHE B 127 −67.111 −57.279 −32.724 1.00 51.61 N ATOM 9952 CA PHE B 127 −68.362 −56.936 −32.055 1.00 51.23 C ATOM 9954 CB PHE B 127 −68.506 −55.416 −31.905 1.00 51.21 C ATOM 9957 CG PHE B 127 −67.702 −54.848 −30.770 1.00 50.58 C ATOM 9958 CD1 PHE B 127 −66.513 −54.192 −31.003 1.00 50.15 C ATOM 9960 CE1 PHE B 127 −65.777 −53.686 −29.948 1.00 50.15 C ATOM 9962 CZ PHE B 127 −66.225 −53.839 −28.647 1.00 49.71 C ATOM 9964 CE2 PHE B 127 −67.399 −54.496 −28.405 1.00 49.50 C ATOM 9966 CD2 PHE B 127 −68.132 −54.999 −29.459 1.00 49.99 C ATOM 9968 C PHE B 127 −69.537 −57.505 −32.821 1.00 50.99 C ATOM 9969 O PHE B 127 −69.468 −57.641 −34.040 1.00 50.92 O ATOM 9971 N LEU B 128 −70.609 −57.840 −32.106 1.00 50.83 N ATOM 9972 CA LEU B 128 −71.799 −58.422 −32.731 1.00 50.76 C ATOM 9974 CB LEU B 128 −72.780 −58.953 −31.669 1.00 50.80 C ATOM 9977 CG LEU B 128 −72.341 −60.098 −30.734 1.00 50.91 C ATOM 9979 CD1 LEU B 128 −73.483 −60.532 −29.813 1.00 50.61 C ATOM 9983 CD2 LEU B 128 −71.818 −61.303 −31.497 1.00 50.79 C ATOM 9987 C LEU B 128 −72.500 −57.407 −33.646 1.00 50.55 C ATOM 9988 O LEU B 128 −73.105 −56.455 −33.171 1.00 50.34 O ATOM 9990 N GLU B 129 −72.402 −57.628 −34.957 1.00 50.50 N ATOM 9991 CA GLU B 129 −73.038 −56.783 −35.982 1.00 50.48 C ATOM 9993 CB GLU B 129 −73.150 −57.551 −37.310 1.00 50.68 C ATOM 9996 CG GLU B 129 −72.262 −57.024 −38.434 1.00 51.36 C ATOM 9999 CD GLU B 129 −72.799 −55.745 −39.060 1.00 51.88 C ATOM 10000 OE1 GLU B 129 −72.110 −54.707 −38.961 1.00 52.72 O ATOM 10001 OE2 GLU B 129 −73.906 −55.773 −39.643 1.00 51.58 O ATOM 10002 C GLU B 129 −74.428 −56.264 −35.629 1.00 50.25 C ATOM 10003 O GLU B 129 −74.737 −55.110 −35.899 1.00 50.18 O ATOM 10005 N ASN B 130 −75.263 −57.125 −35.047 1.00 50.06 N ATOM 10006 CA ASN B 130 −76.678 −56.806 −34.785 1.00 49.71 C ATOM 10008 CB ASN B 130 −77.477 −58.100 −34.550 1.00 49.69 C ATOM 10011 CG ASN B 130 −77.053 −58.837 −33.291 1.00 49.39 C ATOM 10012 OD1 ASN B 130 −76.357 −59.848 −33.361 1.00 48.74 O ATOM 10013 ND2 ASN B 130 −77.468 −58.329 −32.134 1.00 48.99 N ATOM 10016 C ASN B 130 −76.934 −55.800 −33.646 1.00 49.37 C ATOM 10017 O ASN B 130 −78.083 −55.456 −33.366 1.00 49.29 O ATOM 10019 N LEU B 131 −75.868 −55.336 −32.996 1.00 48.98 N ATOM 10020 CA LEU B 131 −75.957 −54.279 −31.988 1.00 48.56 C ATOM 10022 CB LEU B 131 −74.797 −54.392 −30.991 1.00 48.44 C ATOM 10025 CG LEU B 131 −74.759 −55.671 −30.148 1.00 48.19 C ATOM 10027 CD1 LEU B 131 −73.382 −55.852 −29.523 1.00 47.23 C ATOM 10031 CD2 LEU B 131 −75.861 −55.670 −29.083 1.00 47.77 C ATOM 10035 C LEU B 131 −75.968 −52.875 −32.604 1.00 48.29 C ATOM 10036 O LEU B 131 −76.022 −51.895 −31.874 1.00 48.44 O ATOM 10038 N LYS B 132 −75.927 −52.771 −33.934 1.00 47.95 N ATOM 10039 CA LYS B 132 −76.020 −51.471 −34.621 1.00 47.64 C ATOM 10041 CB LYS B 132 −75.548 −51.590 −36.080 1.00 47.63 C ATOM 10044 CG LYS B 132 −76.595 −52.235 −36.998 1.00 48.19 C ATOM 10047 CD LYS B 132 −76.111 −52.483 −38.429 1.00 48.16 C ATOM 10050 CE LYS B 132 −77.239 −53.040 −39.290 1.00 47.23 C ATOM 10053 NZ LYS B 132 −76.725 −53.936 −40.331 1.00 47.01 N ATOM 10057 C LYS B 132 −77.449 −50.907 −34.597 1.00 47.13 C ATOM 10058 O LYS B 132 −77.683 −49.772 −35.005 1.00 46.87 O ATOM 10060 N GLU B 133 −78.403 −51.716 −34.149 1.00 46.77 N ATOM 10061 CA GLU B 133 −79.806 −51.315 −34.107 1.00 46.49 C ATOM 10063 CB GLU B 133 −80.691 −52.458 −34.622 1.00 46.56 C ATOM 10066 CG GLU B 133 −80.732 −52.515 −36.155 1.00 47.01 C ATOM 10069 CD GLU B 133 −80.737 −53.926 −36.715 1.00 47.40 C ATOM 10070 OE1 GLU B 133 −81.500 −54.775 −36.206 1.00 47.97 O ATOM 10071 OE2 GLU B 133 −79.983 −54.177 −37.679 1.00 47.22 O ATOM 10072 C GLU B 133 −80.260 −50.830 −32.723 1.00 45.92 C ATOM 10073 O GLU B 133 −81.369 −50.308 −32.600 1.00 46.14 O ATOM 10075 N ASP B 134 −79.424 −51.002 −31.691 1.00 44.98 N ATOM 10076 CA ASP B 134 −79.611 −50.277 −30.428 1.00 44.14 C ATOM 10078 CB ASP B 134 −79.375 −51.162 −29.197 1.00 43.95 C ATOM 10081 CG ASP B 134 −79.646 −50.419 −27.883 1.00 43.57 C ATOM 10082 OD1 ASP B 134 −80.014 −49.230 −27.919 1.00 42.21 O ATOM 10083 OD2 ASP B 134 −79.488 −51.011 −26.802 1.00 43.69 O ATOM 10084 C ASP B 134 −78.662 −49.073 −30.426 1.00 43.47 C ATOM 10085 O ASP B 134 −77.478 −49.196 −30.104 1.00 43.55 O ATOM 10087 N ILE B 135 −79.198 −47.908 −30.776 1.00 42.47 N ATOM 10088 CA ILE B 135 −78.375 −46.739 −31.033 1.00 41.65 C ATOM 10090 CB ILE B 135 −79.080 −45.783 −32.012 1.00 41.45 C ATOM 10092 CG1 ILE B 135 −78.877 −46.313 −33.434 1.00 41.74 C ATOM 10095 CD1 ILE B 135 −79.174 −45.331 −34.540 1.00 42.77 C ATOM 10099 CG2 ILE B 135 −78.533 −44.391 −31.905 1.00 41.68 C ATOM 10103 C ILE B 135 −77.901 −46.059 −29.746 1.00 41.14 C ATOM 10104 O ILE B 135 −76.752 −45.624 −29.676 1.00 41.11 O ATOM 10106 N LYS B 136 −78.742 −45.998 −28.714 1.00 40.53 N ATOM 10107 CA LYS B 136 −78.281 −45.480 −27.409 1.00 40.10 C ATOM 10109 CB LYS B 136 −79.431 −45.361 −26.375 1.00 40.40 C ATOM 10112 CG LYS B 136 −79.910 −46.697 −25.786 1.00 42.49 C ATOM 10115 CD LYS B 136 −81.002 −46.574 −24.698 1.00 44.79 C ATOM 10118 CE LYS B 136 −81.599 −47.994 −24.363 1.00 46.03 C ATOM 10121 NZ LYS B 136 −82.231 −48.149 −22.994 1.00 46.23 N ATOM 10125 C LYS B 136 −77.104 −46.327 −26.863 1.00 38.85 C ATOM 10126 O LYS B 136 −76.246 −45.806 −26.143 1.00 38.91 O ATOM 10128 N ALA B 137 −77.062 −47.617 −27.219 1.00 37.27 N ATOM 10129 CA ALA B 137 −75.935 −48.486 −26.864 1.00 35.88 C ATOM 10131 CB ALA B 137 −76.255 −49.952 −27.116 1.00 35.69 C ATOM 10135 C ALA B 137 −74.708 −48.085 −27.645 1.00 34.63 C ATOM 10136 O ALA B 137 −73.647 −47.894 −27.055 1.00 34.70 O ATOM 10138 N ILE B 138 −74.845 −47.946 −28.965 1.00 33.12 N ATOM 10139 CA ILE B 138 −73.693 −47.597 −29.805 1.00 31.97 C ATOM 10141 CB ILE B 138 −74.020 −47.572 −31.296 1.00 31.50 C ATOM 10143 CG1 ILE B 138 −74.433 −48.955 −31.774 1.00 31.28 C ATOM 10146 CD1 ILE B 138 −73.460 −50.052 −31.417 1.00 30.86 C ATOM 10150 CG2 ILE B 138 −72.819 −47.138 −32.073 1.00 30.61 C ATOM 10154 C ILE B 138 −73.124 −46.245 −29.413 1.00 31.57 C ATOM 10155 O ILE B 138 −71.909 −46.090 −29.305 1.00 31.77 O ATOM 10157 N LEU B 139 −73.997 −45.268 −29.192 1.00 30.92 N ATOM 10158 CA LEU B 139 −73.555 −43.962 −28.713 1.00 30.29 C ATOM 10160 CB LEU B 139 −74.732 −43.000 −28.530 1.00 30.13 C ATOM 10163 CG LEU B 139 −74.778 −41.890 −29.574 1.00 29.96 C ATOM 10165 CD1 LEU B 139 −73.496 −41.060 −29.508 1.00 28.26 C ATOM 10169 CD2 LEU B 139 −76.022 −41.019 −29.397 1.00 29.48 C ATOM 10173 C LEU B 139 −72.835 −44.136 −27.397 1.00 29.95 C ATOM 10174 O LEU B 139 −71.709 −43.687 −27.232 1.00 30.45 O ATOM 10176 N SER B 140 −73.492 −44.807 −26.463 1.00 29.33 N ATOM 10177 CA SER B 140 −72.916 −45.061 −25.150 1.00 28.84 C ATOM 10179 CB SER B 140 −73.900 −45.878 −24.298 1.00 28.93 C ATOM 10182 OG SER B 140 −73.527 −45.870 −22.930 1.00 30.33 O ATOM 10184 C SER B 140 −71.555 −45.770 −25.243 1.00 27.78 C ATOM 10185 O SER B 140 −70.637 −45.454 −24.489 1.00 27.46 O ATOM 10187 N LEU B 141 −71.432 −46.719 −26.167 1.00 26.82 N ATOM 10188 CA LEU B 141 −70.178 −47.433 −26.348 1.00 26.34 C ATOM 10190 CB LEU B 141 −70.366 −48.658 −27.256 1.00 26.16 C ATOM 10193 CG LEU B 141 −69.098 −49.472 −27.584 1.00 26.09 C ATOM 10195 CD1 LEU B 141 −68.355 −49.960 −26.330 1.00 24.64 C ATOM 10199 CD2 LEU B 141 −69.455 −50.643 −28.481 1.00 25.94 C ATOM 10203 C LEU B 141 −69.124 −46.476 −26.914 1.00 25.89 C ATOM 10204 O LEU B 141 −68.025 −46.346 −26.366 1.00 25.77 O ATOM 10206 N TYR B 142 −69.471 −45.809 −28.008 1.00 25.41 N ATOM 10207 CA TYR B 142 −68.609 −44.804 −28.610 1.00 25.03 C ATOM 10209 CB TYR B 142 −69.399 −43.982 −29.617 1.00 24.80 C ATOM 10212 CG TYR B 142 −68.736 −42.695 −30.043 1.00 24.47 C ATOM 10213 CD1 TYR B 142 −67.761 −42.686 −31.029 1.00 24.18 C ATOM 10215 CE1 TYR B 142 −67.166 −41.516 −31.438 1.00 24.70 C ATOM 10217 CZ TYR B 142 −67.548 −40.315 −30.871 1.00 25.80 C ATOM 10218 OH TYR B 142 −66.940 −39.129 −31.279 1.00 27.63 O ATOM 10220 CE2 TYR B 142 −68.522 −40.299 −29.890 1.00 25.57 C ATOM 10222 CD2 TYR B 142 −69.110 −41.485 −29.485 1.00 24.73 C ATOM 10224 C TYR B 142 −68.095 −43.883 −27.537 1.00 25.17 C ATOM 10225 O TYR B 142 −66.886 −43.732 −27.360 1.00 25.40 O ATOM 10227 N GLU B 143 −69.038 −43.293 −26.807 1.00 25.12 N ATOM 10228 CA GLU B 143 −68.744 −42.256 −25.828 1.00 25.10 C ATOM 10230 CB GLU B 143 −70.046 −41.726 −25.226 1.00 25.33 C ATOM 10233 CG GLU B 143 −70.006 −40.244 −24.849 1.00 27.57 C ATOM 10236 CD GLU B 143 −70.321 −39.313 −26.023 1.00 30.43 C ATOM 10237 OE1 GLU B 143 −69.343 −38.764 −26.583 1.00 32.89 O ATOM 10238 OE2 GLU B 143 −71.526 −39.130 −26.377 1.00 30.86 O ATOM 10239 C GLU B 143 −67.794 −42.746 −24.729 1.00 24.43 C ATOM 10240 O GLU B 143 −67.026 −41.959 −24.179 1.00 24.06 O ATOM 10242 N ALA B 144 −67.840 −44.050 −24.449 1.00 24.01 N ATOM 10243 CA ALA B 144 −67.033 −44.681 −23.399 1.00 23.74 C ATOM 10245 CB ALA B 144 −67.726 −45.943 −22.883 1.00 23.48 C ATOM 10249 C ALA B 144 −65.631 −45.025 −23.864 1.00 23.57 C ATOM 10250 O ALA B 144 −64.720 −45.171 −23.060 1.00 23.69 O ATOM 10252 N SER B 145 −65.455 −45.168 −25.165 1.00 23.45 N ATOM 10253 CA SER B 145 −64.168 −45.568 −25.701 1.00 23.44 C ATOM 10255 CB SER B 145 −64.300 −45.856 −27.214 1.00 23.63 C ATOM 10258 OG SER B 145 −64.822 −44.748 −27.952 1.00 24.24 O ATOM 10260 C SER B 145 −63.065 −44.520 −25.416 1.00 23.24 C ATOM 10261 O SER B 145 −61.877 −44.848 −25.288 1.00 23.25 O ATOM 10263 N PHE B 146 −63.454 −43.257 −25.285 1.00 22.92 N ATOM 10264 CA PHE B 146 −62.464 −42.189 −25.170 1.00 22.35 C ATOM 10266 CB PHE B 146 −63.090 −40.837 −25.478 1.00 22.09 C ATOM 10269 CG PHE B 146 −63.505 −40.717 −26.911 1.00 22.40 C ATOM 10270 CD1 PHE B 146 −62.619 −40.229 −27.868 1.00 21.98 C ATOM 10272 CE1 PHE B 146 −62.985 −40.156 −29.201 1.00 21.80 C ATOM 10274 CZ PHE B 146 −64.241 −40.579 −29.594 1.00 21.91 C ATOM 10276 CE2 PHE B 146 −65.123 −41.098 −28.649 1.00 22.29 C ATOM 10278 CD2 PHE B 146 −64.751 −41.170 −27.323 1.00 22.34 C ATOM 10280 C PHE B 146 −61.762 −42.208 −23.837 1.00 21.91 C ATOM 10281 O PHE B 146 −60.669 −41.683 −23.733 1.00 22.30 O ATOM 10283 N LEU B 147 −62.361 −42.864 −22.841 1.00 21.27 N ATOM 10284 CA LEU B 147 −61.727 −43.050 −21.535 1.00 20.49 C ATOM 10286 CB LEU B 147 −62.791 −43.333 −20.478 1.00 20.14 C ATOM 10289 CG LEU B 147 −63.609 −42.109 −20.102 1.00 18.87 C ATOM 10291 CD1 LEU B 147 −64.813 −42.020 −20.959 1.00 15.94 C ATOM 10295 CD2 LEU B 147 −63.988 −42.189 −18.642 1.00 18.62 C ATOM 10299 C LEU B 147 −60.678 −44.163 −21.498 1.00 20.41 C ATOM 10300 O LEU B 147 −60.243 −44.552 −20.415 1.00 20.44 O ATOM 10302 N ALA B 148 −60.268 −44.664 −22.662 1.00 20.28 N ATOM 10303 CA ALA B 148 −59.330 −45.784 −22.745 1.00 20.33 C ATOM 10305 CB ALA B 148 −59.188 −46.231 −24.194 1.00 20.15 C ATOM 10309 C ALA B 148 −57.952 −45.462 −22.170 1.00 20.54 C ATOM 10310 O ALA B 148 −57.435 −44.366 −22.341 1.00 20.23 O ATOM 10312 N LEU B 149 −57.366 −46.435 −21.486 1.00 21.19 N ATOM 10313 CA LEU B 149 −55.969 −46.354 −21.067 1.00 22.02 C ATOM 10315 CB LEU B 149 −55.768 −47.073 −19.725 1.00 21.90 C ATOM 10318 CG LEU B 149 −56.541 −46.496 −18.523 1.00 21.50 C ATOM 10320 CD1 LEU B 149 −55.979 −47.006 −17.223 1.00 20.96 C ATOM 10324 CD2 LEU B 149 −56.520 −44.974 −18.505 1.00 20.95 C ATOM 10328 C LEU B 149 −55.054 −46.930 −22.159 1.00 22.84 C ATOM 10329 O LEU B 149 −55.507 −47.678 −23.017 1.00 22.91 O ATOM 10331 N GLU B 150 −53.781 −46.550 −22.163 1.00 23.93 N ATOM 10332 CA GLU B 150 −52.858 −47.071 −23.174 1.00 25.03 C ATOM 10334 CB GLU B 150 −51.472 −46.431 −23.012 1.00 25.41 C ATOM 10337 CG GLU B 150 −50.530 −46.608 −24.213 1.00 27.44 C ATOM 10340 CD GLU B 150 −49.132 −45.987 −23.992 1.00 30.04 C ATOM 10341 OE1 GLU B 150 −48.925 −45.330 −22.943 1.00 31.41 O ATOM 10342 OE2 GLU B 150 −48.242 −46.161 −24.867 1.00 30.34 O ATOM 10343 C GLU B 150 −52.787 −48.600 −23.024 1.00 25.36 C ATOM 10344 O GLU B 150 −52.613 −49.098 −21.911 1.00 25.58 O ATOM 10346 N GLY B 151 −52.968 −49.337 −24.122 1.00 25.79 N ATOM 10347 CA GLY B 151 −52.959 −50.816 −24.086 1.00 26.11 C ATOM 10350 C GLY B 151 −54.323 −51.522 −24.047 1.00 26.44 C ATOM 10351 O GLY B 151 −54.393 −52.747 −24.135 1.00 26.91 O ATOM 10353 N GLU B 152 −55.407 −50.768 −23.899 1.00 26.58 N ATOM 10354 CA GLU B 152 −56.757 −51.319 −23.971 1.00 26.57 C ATOM 10356 CB GLU B 152 −57.697 −50.531 −23.065 1.00 26.74 C ATOM 10359 CG GLU B 152 −57.291 −50.595 −21.596 1.00 27.63 C ATOM 10362 CD GLU B 152 −58.271 −49.893 −20.668 1.00 28.86 C ATOM 10363 OE1 GLU B 152 −58.239 −50.192 −19.449 1.00 28.80 O ATOM 10364 OE2 GLU B 152 −59.066 −49.044 −21.154 1.00 29.26 O ATOM 10365 C GLU B 152 −57.254 −51.303 −25.415 1.00 26.53 C ATOM 10366 O GLU B 152 −57.937 −50.381 −25.869 1.00 26.00 O ATOM 10368 N ASN B 153 −56.888 −52.354 −26.127 1.00 26.77 N ATOM 10369 CA ASN B 153 −57.189 −52.498 −27.545 1.00 27.05 C ATOM 10371 CB ASN B 153 −56.345 −53.640 −28.104 1.00 27.12 C ATOM 10374 CG ASN B 153 −56.770 −54.992 −27.549 1.00 27.81 C ATOM 10375 OD1 ASN B 153 −56.540 −55.307 −26.379 1.00 27.65 O ATOM 10376 ND2 ASN B 153 −57.426 −55.782 −28.382 1.00 29.43 N ATOM 10379 C ASN B 153 −58.659 −52.788 −27.873 1.00 27.09 C ATOM 10380 O ASN B 153 −59.053 −52.658 −29.029 1.00 27.11 O ATOM 10382 N ILE B 154 −59.448 −53.223 −26.884 1.00 27.17 N ATOM 10383 CA ILE B 154 −60.865 −53.544 −27.100 1.00 27.11 C ATOM 10385 CB ILE B 154 −61.454 −54.369 −25.956 1.00 26.99 C ATOM 10387 CG1 ILE B 154 −60.811 −55.750 −25.907 1.00 27.16 C ATOM 10390 CD1 ILE B 154 −61.309 −56.622 −24.746 1.00 27.41 C ATOM 10394 CG2 ILE B 154 −62.953 −54.519 −26.124 1.00 26.65 C ATOM 10398 C ILE B 154 −61.704 −52.284 −27.229 1.00 27.43 C ATOM 10399 O ILE B 154 −62.718 −52.279 −27.939 1.00 27.39 O ATOM 10401 N LEU B 155 −61.296 −51.226 −26.522 1.00 27.76 N ATOM 10402 CA LEU B 155 −61.964 −49.918 −26.609 1.00 27.75 C ATOM 10404 CB LEU B 155 −61.578 −49.024 −25.430 1.00 27.31 C ATOM 10407 CG LEU B 155 −61.968 −49.544 −24.052 1.00 26.64 C ATOM 10409 CD1 LEU B 155 −61.444 −48.631 −22.981 1.00 25.82 C ATOM 10413 CD2 LEU B 155 −63.465 −49.674 −23.944 1.00 26.45 C ATOM 10417 C LEU B 155 −61.620 −49.226 −27.924 1.00 28.32 C ATOM 10418 O LEU B 155 −62.499 −48.672 −28.583 1.00 28.72 O ATOM 10420 N ASP B 156 −60.348 −49.264 −28.309 1.00 28.84 N ATOM 10421 CA ASP B 156 −59.934 −48.737 −29.601 1.00 29.43 C ATOM 10423 CB ASP B 156 −58.423 −48.928 −29.823 1.00 29.92 C ATOM 10426 CG ASP B 156 −57.566 −47.912 −29.045 1.00 31.35 C ATOM 10427 OD1 ASP B 156 −57.803 −46.680 −29.162 1.00 33.23 O ATOM 10428 OD2 ASP B 156 −56.640 −48.351 −28.324 1.00 33.08 O ATOM 10429 C ASP B 156 −60.719 −49.411 −30.717 1.00 29.36 C ATOM 10430 O ASP B 156 −61.075 −48.768 −31.697 1.00 29.33 O ATOM 10432 N GLU B 157 −60.981 −50.705 −30.558 1.00 29.63 N ATOM 10433 CA GLU B 157 −61.845 −51.457 −31.479 1.00 29.98 C ATOM 10435 CB GLU B 157 −61.729 −52.971 −31.234 1.00 30.30 C ATOM 10438 CG GLU B 157 −60.664 −53.647 −32.087 1.00 31.79 C ATOM 10441 CD GLU B 157 −60.075 −54.901 −31.439 1.00 33.87 C ATOM 10442 OE1 GLU B 157 −60.793 −55.560 −30.640 1.00 35.07 O ATOM 10443 OE2 GLU B 157 −58.894 −55.223 −31.743 1.00 33.70 O ATOM 10444 C GLU B 157 −63.304 −51.030 −31.349 1.00 29.53 C ATOM 10445 O GLU B 157 −63.999 −50.878 −32.351 1.00 29.53 O ATOM 10447 N ALA B 158 −63.758 −50.853 −30.112 1.00 29.11 N ATOM 10448 CA ALA B 158 −65.104 −50.370 −29.840 1.00 28.87 C ATOM 10450 CB ALA B 158 −65.307 −50.195 −28.351 1.00 28.82 C ATOM 10454 C ALA B 158 −65.383 −49.065 −30.567 1.00 28.73 C ATOM 10455 O ALA B 158 −66.485 −48.857 −31.065 1.00 28.80 O ATOM 10457 N LYS B 159 −64.385 −48.197 −30.642 1.00 28.65 N ATOM 10458 CA LYS B 159 −64.553 −46.910 −31.296 1.00 28.98 C ATOM 10460 CB LYS B 159 −63.439 −45.950 −30.857 1.00 29.16 C ATOM 10463 CG LYS B 159 −63.558 −44.536 −31.426 1.00 29.82 C ATOM 10466 CD LYS B 159 −62.812 −43.493 −30.592 1.00 30.96 C ATOM 10469 CE LYS B 159 −61.295 −43.610 −30.691 1.00 31.57 C ATOM 10472 NZ LYS B 159 −60.630 −42.426 −30.079 1.00 31.49 N ATOM 10476 C LYS B 159 −64.594 −47.041 −32.826 1.00 29.08 C ATOM 10477 O LYS B 159 −65.385 −46.372 −33.486 1.00 28.73 O ATOM 10479 N VAL B 160 −63.736 −47.891 −33.386 1.00 29.53 N ATOM 10480 CA VAL B 160 −63.686 −48.087 −34.836 1.00 29.89 C ATOM 10482 CB VAL B 160 −62.466 −48.971 −35.282 1.00 29.93 C ATOM 10484 CG1 VAL B 160 −62.576 −49.375 −36.756 1.00 29.58 C ATOM 10488 CG2 VAL B 160 −61.152 −48.244 −35.040 1.00 29.41 C ATOM 10492 C VAL B 160 −65.001 −48.723 −35.263 1.00 30.32 C ATOM 10493 O VAL B 160 −65.507 −48.459 −36.362 1.00 30.41 O ATOM 10495 N PHE B 161 −65.558 −49.540 −34.371 1.00 30.83 N ATOM 10496 CA PHE B 161 −66.854 −50.178 −34.599 1.00 31.34 C ATOM 10498 CB PHE B 161 −67.090 −51.321 −33.599 1.00 31.34 C ATOM 10501 CG PHE B 161 −68.492 −51.834 −33.603 1.00 31.09 C ATOM 10502 CD1 PHE B 161 −68.940 −52.636 −34.633 1.00 31.61 C ATOM 10504 CE1 PHE B 161 −70.249 −53.098 −34.649 1.00 31.48 C ATOM 10506 CZ PHE B 161 −71.114 −52.748 −33.628 1.00 30.76 C ATOM 10508 CE2 PHE B 161 −70.677 −51.944 −32.606 1.00 30.19 C ATOM 10510 CD2 PHE B 161 −69.378 −51.486 −32.597 1.00 30.70 C ATOM 10512 C PHE B 161 −67.992 −49.173 −34.504 1.00 31.65 C ATOM 10513 O PHE B 161 −68.785 −49.038 −35.432 1.00 31.62 O ATOM 10515 N ALA B 162 −68.068 −48.483 −33.373 1.00 32.26 N ATOM 10516 CA ALA B 162 −69.135 −47.519 −33.129 1.00 32.84 C ATOM 10518 CB ALA B 162 −68.948 −46.854 −31.778 1.00 32.66 C ATOM 10522 C ALA B 162 −69.224 −46.474 −34.245 1.00 33.40 C ATOM 10523 O ALA B 162 −70.229 −46.408 −34.937 1.00 33.45 O ATOM 10525 N ILE B 163 −68.164 −45.697 −34.444 1.00 34.38 N ATOM 10526 CA ILE B 163 −68.166 −44.610 −35.439 1.00 35.23 C ATOM 10528 CB ILE B 163 −66.734 −44.062 −35.733 1.00 35.18 C ATOM 10530 CG1 ILE B 163 −66.092 −43.457 −34.488 1.00 35.21 C ATOM 10533 CD1 ILE B 163 −64.620 −43.171 −34.663 1.00 35.96 C ATOM 10537 CG2 ILE B 163 −66.778 −42.977 −36.799 1.00 34.72 C ATOM 10541 C ILE B 163 −68.778 −45.052 −36.766 1.00 36.18 C ATOM 10542 O ILE B 163 −69.588 −44.335 −37.360 1.00 35.87 O ATOM 10544 N SER B 164 −68.379 −46.240 −37.217 1.00 37.67 N ATOM 10545 CA SER B 164 −68.761 −46.752 −38.539 1.00 38.74 C ATOM 10547 CB SER B 164 −68.104 −48.117 −38.815 1.00 38.80 C ATOM 10550 OG SER B 164 −68.733 −49.158 −38.077 1.00 39.07 O ATOM 10552 C SER B 164 −70.277 −46.861 −38.699 1.00 39.51 C ATOM 10553 O SER B 164 −70.820 −46.494 −39.737 1.00 39.96 O ATOM 10555 N HIS B 165 −70.962 −47.363 −37.680 1.00 40.28 N ATOM 10556 CA HIS B 165 −72.410 −47.485 −37.767 1.00 41.07 C ATOM 10558 CB HIS B 165 −72.911 −48.686 −36.957 1.00 41.38 C ATOM 10561 CG HIS B 165 −72.571 −50.005 −37.587 1.00 42.65 C ATOM 10562 ND1 HIS B 165 −71.647 −50.875 −37.046 1.00 43.54 N ATOM 10564 CE1 HIS B 165 −71.535 −51.938 −37.825 1.00 43.54 C ATOM 10566 NE2 HIS B 165 −72.346 −51.785 −38.858 1.00 43.25 N ATOM 10568 CD2 HIS B 165 −73.001 −50.582 −38.737 1.00 43.31 C ATOM 10570 C HIS B 165 −73.125 −46.193 −37.380 1.00 41.21 C ATOM 10571 O HIS B 165 −74.257 −45.980 −37.805 1.00 41.53 O ATOM 10573 N LEU B 166 −72.459 −45.326 −36.614 1.00 41.32 N ATOM 10574 CA LEU B 166 −73.042 −44.039 −36.201 1.00 41.31 C ATOM 10576 CB LEU B 166 −72.317 −43.460 −34.973 1.00 41.14 C ATOM 10579 CG LEU B 166 −72.732 −43.975 −33.589 1.00 40.03 C ATOM 10581 CD1 LEU B 166 −71.673 −43.634 −32.579 1.00 38.86 C ATOM 10585 CD2 LEU B 166 −74.077 −43.421 −33.151 1.00 38.52 C ATOM 10589 C LEU B 166 −73.045 −42.992 −37.313 1.00 41.80 C ATOM 10590 O LEU B 166 −74.006 −42.230 −37.442 1.00 41.73 O ATOM 10592 N LYS B 167 −71.982 −42.947 −38.116 1.00 42.47 N ATOM 10593 CA LYS B 167 −71.847 −41.891 −39.137 1.00 43.00 C ATOM 10595 CB LYS B 167 −70.416 −41.822 −39.702 1.00 43.12 C ATOM 10598 CG LYS B 167 −69.937 −43.068 −40.450 1.00 44.12 C ATOM 10601 CD LYS B 167 −69.138 −42.725 −41.736 1.00 45.36 C ATOM 10604 CE LYS B 167 −67.898 −41.842 −41.483 1.00 45.65 C ATOM 10607 NZ LYS B 167 −67.267 −41.400 −42.762 1.00 44.94 N ATOM 10611 C LYS B 167 −72.873 −41.950 −40.283 1.00 42.99 C ATOM 10612 O LYS B 167 −72.826 −41.124 −41.182 1.00 42.95 O ATOM 10614 N GLU B 168 −73.791 −42.912 −40.244 1.00 43.23 N ATOM 10615 CA GLU B 168 −74.928 −42.940 −41.167 1.00 43.44 C ATOM 10617 CB GLU B 168 −74.652 −43.969 −42.272 1.00 43.58 C ATOM 10620 CG GLU B 168 −73.918 −43.363 −43.501 1.00 44.36 C ATOM 10623 CD GLU B 168 −72.618 −44.082 −43.895 1.00 44.53 C ATOM 10624 OE1 GLU B 168 −71.853 −44.494 −42.992 1.00 44.71 O ATOM 10625 OE2 GLU B 168 −72.351 −44.197 −45.115 1.00 43.31 O ATOM 10626 C GLU B 168 −76.263 −43.214 −40.442 1.00 43.24 C ATOM 10627 O GLU B 168 −76.932 −42.291 −39.942 1.00 42.54 O ATOM 10629 N GLY B 175 −83.548 −42.037 −36.239 1.00 49.43 N ATOM 10630 CA GLY B 175 −84.473 −41.266 −35.416 1.00 49.54 C ATOM 10633 C GLY B 175 −84.709 −39.884 −36.001 1.00 49.76 C ATOM 10634 O GLY B 175 −84.828 −39.741 −37.220 1.00 49.70 O ATOM 10636 N LYS B 176 −84.766 −38.870 −35.131 1.00 49.95 N ATOM 10637 CA LYS B 176 −85.014 −37.468 −35.534 1.00 50.05 C ATOM 10639 CB LYS B 176 −86.522 −37.225 −35.730 1.00 50.27 C ATOM 10642 CG LYS B 176 −87.301 −36.813 −34.460 1.00 51.33 C ATOM 10645 CD LYS B 176 −88.553 −37.658 −34.202 1.00 52.21 C ATOM 10648 CE LYS B 176 −88.841 −37.754 −32.695 1.00 52.36 C ATOM 10651 NZ LYS B 176 −90.029 −38.607 −32.422 1.00 52.15 N ATOM 10655 C LYS B 176 −84.427 −36.432 −34.554 1.00 49.75 C ATOM 10656 O LYS B 176 −83.990 −35.370 −34.972 1.00 49.88 O ATOM 10658 N GLU B 177 −84.473 −36.729 −33.254 1.00 49.46 N ATOM 10659 CA GLU B 177 −83.769 −35.959 −32.221 1.00 48.92 C ATOM 10661 CB GLU B 177 −84.628 −35.813 −30.946 1.00 49.03 C ATOM 10664 CG GLU B 177 −84.196 −36.691 −29.732 1.00 49.60 C ATOM 10667 CD GLU B 177 −85.278 −36.871 −28.662 1.00 50.10 C ATOM 10668 OE1 GLU B 177 −84.998 −37.576 −27.670 1.00 49.78 O ATOM 10669 OE2 GLU B 177 −86.401 −36.336 −28.808 1.00 50.78 O ATOM 10670 C GLU B 177 −82.469 −36.703 −31.924 1.00 48.19 C ATOM 10671 O GLU B 177 −81.421 −36.085 −31.721 1.00 48.68 O ATOM 10673 N LEU B 178 −82.557 −38.037 −31.900 1.00 46.98 N ATOM 10674 CA LEU B 178 −81.398 −38.924 −31.817 1.00 45.91 C ATOM 10676 CB LEU B 178 −81.838 −40.387 −31.945 1.00 45.70 C ATOM 10679 CG LEU B 178 −81.111 −41.408 −31.074 1.00 45.24 C ATOM 10681 CD1 LEU B 178 −81.498 −41.225 −29.609 1.00 44.88 C ATOM 10685 CD2 LEU B 178 −81.413 −42.826 −31.539 1.00 44.19 C ATOM 10689 C LEU B 178 −80.423 −38.571 −32.934 1.00 45.27 C ATOM 10690 O LEU B 178 −79.211 −38.624 −32.759 1.00 44.99 O ATOM 10692 N ALA B 179 −80.970 −38.203 −34.088 1.00 44.75 N ATOM 10693 CA ALA B 179 −80.174 −37.661 −35.181 1.00 44.24 C ATOM 10695 CB ALA B 179 −81.088 −37.069 −36.231 1.00 44.30 C ATOM 10699 C ALA B 179 −79.192 −36.602 −34.683 1.00 43.65 C ATOM 10700 O ALA B 179 −78.028 −36.604 −35.061 1.00 43.56 O ATOM 10702 N GLU B 180 −79.675 −35.707 −33.827 1.00 43.01 N ATOM 10703 CA GLU B 180 −78.863 −34.610 −33.311 1.00 42.49 C ATOM 10705 CB GLU B 180 −79.749 −33.477 −32.789 1.00 42.85 C ATOM 10708 CG GLU B 180 −80.574 −32.800 −33.881 1.00 44.23 C ATOM 10711 CD GLU B 180 −80.991 −31.382 −33.519 1.00 45.80 C ATOM 10712 OE1 GLU B 180 −80.098 −30.580 −33.156 1.00 46.69 O ATOM 10713 OE2 GLU B 180 −82.203 −31.065 −33.610 1.00 46.71 O ATOM 10714 C GLU B 180 −77.944 −35.075 −32.210 1.00 41.39 C ATOM 10715 O GLU B 180 −76.843 −34.562 −32.071 1.00 41.27 O ATOM 10717 N GLN B 181 −78.404 −36.035 −31.419 1.00 40.20 N ATOM 10718 CA GLN B 181 −77.570 −36.632 −30.394 1.00 39.45 C ATOM 10720 CB GLN B 181 −78.280 −37.809 −29.736 1.00 39.88 C ATOM 10723 CG GLN B 181 −78.005 −37.959 −28.249 1.00 41.64 C ATOM 10726 CD GLN B 181 −78.873 −37.036 −27.404 1.00 44.00 C ATOM 10727 OE1 GLN B 181 −80.109 −36.992 −27.581 1.00 45.65 O ATOM 10728 NE2 GLN B 181 −78.235 −36.291 −26.474 1.00 43.41 N ATOM 10731 C GLN B 181 −76.270 −37.120 −31.003 1.00 38.28 C ATOM 10732 O GLN B 181 −75.203 −36.767 −30.523 1.00 38.27 O ATOM 10734 N VAL B 182 −76.358 −37.911 −32.072 1.00 37.05 N ATOM 10735 CA VAL B 182 −75.160 −38.515 −32.675 1.00 36.20 C ATOM 10737 CB VAL B 182 −75.486 −39.661 −33.681 1.00 36.11 C ATOM 10739 CG1 VAL B 182 −76.493 −40.641 −33.080 1.00 36.13 C ATOM 10743 CG2 VAL B 182 −75.977 −39.106 −35.004 1.00 36.06 C ATOM 10747 C VAL B 182 −74.238 −37.495 −33.364 1.00 35.44 C ATOM 10748 O VAL B 182 −73.012 −37.682 −33.375 1.00 35.19 O ATOM 10750 N SER B 183 −74.811 −36.432 −33.936 1.00 34.41 N ATOM 10751 CA SER B 183 −73.998 −35.416 −34.630 1.00 33.74 C ATOM 10753 CB SER B 183 −74.858 −34.438 −35.422 1.00 33.58 C ATOM 10756 OG SER B 183 −76.003 −35.085 −35.925 1.00 34.52 O ATOM 10758 C SER B 183 −73.184 −34.644 −33.625 1.00 32.88 C ATOM 10759 O SER B 183 −72.055 −34.251 −33.906 1.00 33.25 O ATOM 10761 N HIS B 184 −73.788 −34.427 −32.461 1.00 31.83 N ATOM 10762 CA HIS B 184 −73.150 −33.787 −31.326 1.00 30.98 C ATOM 10764 CB HIS B 184 −74.188 −33.627 −30.212 1.00 31.14 C ATOM 10767 CG HIS B 184 −73.710 −32.849 −29.030 1.00 31.91 C ATOM 10768 ND1 HIS B 184 −73.326 −31.527 −29.114 1.00 33.18 N ATOM 10770 CE1 HIS B 184 −72.960 −31.107 −27.914 1.00 33.10 C ATOM 10772 NE2 HIS B 184 −73.106 −32.102 −27.056 1.00 31.85 N ATOM 10774 CD2 HIS B 184 −73.583 −33.200 −27.727 1.00 31.86 C ATOM 10776 C HIS B 184 −71.968 −34.632 −30.865 1.00 30.13 C ATOM 10777 O HIS B 184 −70.863 −34.122 −30.709 1.00 29.95 O ATOM 10779 N ALA B 185 −72.194 −35.931 −30.683 1.00 29.27 N ATOM 10780 CA ALA B 185 −71.123 −36.856 −30.281 1.00 28.64 C ATOM 10782 CB ALA B 185 −71.689 −38.233 −29.986 1.00 28.44 C ATOM 10786 C ALA B 185 −70.017 −36.965 −31.330 1.00 28.08 C ATOM 10787 O ALA B 185 −68.839 −37.043 −30.992 1.00 28.26 O ATOM 10789 N LEU B 186 −70.394 −36.984 −32.602 1.00 27.40 N ATOM 10790 CA LEU B 186 −69.412 −37.101 −33.674 1.00 26.84 C ATOM 10792 CB LEU B 186 −70.088 −37.481 −35.000 1.00 26.75 C ATOM 10795 CG LEU B 186 −70.085 −38.983 −35.320 1.00 26.70 C ATOM 10797 CD1 LEU B 186 −70.214 −39.868 −34.075 1.00 27.07 C ATOM 10801 CD2 LEU B 186 −71.179 −39.306 −36.303 1.00 26.29 C ATOM 10805 C LEU B 186 −68.594 −35.822 −33.815 1.00 26.45 C ATOM 10806 O LEU B 186 −67.449 −35.875 −34.237 1.00 26.48 O ATOM 10808 N GLU B 187 −69.186 −34.685 −33.454 1.00 25.93 N ATOM 10809 CA GLU B 187 −68.479 −33.406 −33.403 1.00 25.57 C ATOM 10811 CB GLU B 187 −69.447 −32.310 −32.962 1.00 25.61 C ATOM 10814 CG GLU B 187 −69.035 −30.899 −33.325 1.00 26.29 C ATOM 10817 CD GLU B 187 −69.930 −29.857 −32.671 1.00 27.10 C ATOM 10818 OE1 GLU B 187 −70.312 −30.057 −31.487 1.00 26.51 O ATOM 10819 OE2 GLU B 187 −70.251 −28.846 −33.344 1.00 27.54 O ATOM 10820 C GLU B 187 −67.307 −33.490 −32.418 1.00 25.13 C ATOM 10821 O GLU B 187 −66.155 −33.165 −32.749 1.00 24.85 O ATOM 10823 N LEU B 188 −67.625 −33.938 −31.204 1.00 24.58 N ATOM 10824 CA LEU B 188 −66.644 −34.137 −30.148 1.00 24.06 C ATOM 10826 CB LEU B 188 −66.343 −32.817 −29.451 1.00 24.12 C ATOM 10829 CG LEU B 188 −65.042 −32.714 −28.670 1.00 23.61 C ATOM 10831 CD1 LEU B 188 −63.895 −32.872 −29.629 1.00 23.12 C ATOM 10835 CD2 LEU B 188 −64.976 −31.368 −27.964 1.00 23.18 C ATOM 10839 C LEU B 188 −67.248 −35.087 −29.140 1.00 23.70 C ATOM 10840 O LEU B 188 −68.392 −34.901 −28.743 1.00 23.68 O ATOM 10842 N PRO B 189 −66.493 −36.106 −28.713 1.00 23.34 N ATOM 10843 CA PRO B 189 −67.031 −36.983 −27.692 1.00 23.08 C ATOM 10845 CB PRO B 189 −66.018 −38.115 −27.638 1.00 22.96 C ATOM 10848 CG PRO B 189 −64.743 −37.452 −27.940 1.00 23.22 C ATOM 10851 CD PRO B 189 −65.059 −36.350 −28.929 1.00 23.54 C ATOM 10854 C PRO B 189 −67.053 −36.229 −26.387 1.00 22.86 C ATOM 10855 O PRO B 189 −66.284 −35.285 −26.215 1.00 23.03 O ATOM 10856 N LEU B 190 −67.912 −36.628 −25.465 1.00 22.56 N ATOM 10857 CA LEU B 190 −68.152 −35.773 −24.323 1.00 22.41 C ATOM 10859 CB LEU B 190 −69.567 −35.970 −23.766 1.00 23.04 C ATOM 10862 CG LEU B 190 −69.853 −37.136 −22.848 1.00 23.41 C ATOM 10864 CD1 LEU B 190 −69.303 −36.733 −21.481 1.00 25.02 C ATOM 10868 CD2 LEU B 190 −71.342 −37.411 −22.820 1.00 21.69 C ATOM 10872 C LEU B 190 −67.065 −35.899 −23.266 1.00 21.56 C ATOM 10873 O LEU B 190 −66.860 −34.976 −22.477 1.00 21.67 O ATOM 10875 N HIS B 191 −66.320 −36.998 −23.283 1.00 20.39 N ATOM 10876 CA HIS B 191 −65.089 −37.037 −22.490 1.00 19.40 C ATOM 10878 CB HIS B 191 −64.399 −38.393 −22.597 1.00 19.19 C ATOM 10881 CG HIS B 191 −63.222 −38.530 −21.689 1.00 19.32 C ATOM 10882 ND1 HIS B 191 −63.347 −38.562 −20.317 1.00 20.95 N ATOM 10884 CE1 HIS B 191 −62.145 −38.659 −19.771 1.00 21.15 C ATOM 10886 NE2 HIS B 191 −61.245 −38.689 −20.741 1.00 19.36 N ATOM 10888 CD2 HIS B 191 −61.893 −38.604 −21.948 1.00 19.49 C ATOM 10890 C HIS B 191 −64.094 −35.913 −22.841 1.00 18.62 C ATOM 10891 O HIS B 191 −63.150 −35.677 −22.085 1.00 18.59 O ATOM 10893 N ARG B 192 −64.307 −35.216 −23.957 1.00 17.72 N ATOM 10894 CA ARG B 192 −63.394 −34.150 −24.394 1.00 17.57 C ATOM 10896 CB ARG B 192 −62.838 −34.504 −25.773 1.00 17.81 C ATOM 10899 CG ARG B 192 −61.971 −35.736 −25.781 1.00 18.59 C ATOM 10902 CD ARG B 192 −61.484 −36.067 −27.181 1.00 20.10 C ATOM 10905 NE ARG B 192 −60.462 −37.116 −27.165 1.00 21.62 N ATOM 10907 CZ ARG B 192 −59.919 −37.648 −28.254 1.00 22.77 C ATOM 10908 NH1 ARG B 192 −60.304 −37.248 −29.454 1.00 24.20 N ATOM 10911 NH2 ARG B 192 −58.987 −38.581 −28.149 1.00 23.37 N ATOM 10914 C ARG B 192 −63.983 −32.726 −24.440 1.00 17.01 C ATOM 10915 O ARG B 192 −63.242 −31.739 −24.526 1.00 15.78 O ATOM 10917 N ARG B 193 −65.309 −32.634 −24.392 1.00 17.01 N ATOM 10918 CA ARG B 193 −66.015 −31.350 −24.453 1.00 16.99 C ATOM 10920 CB ARG B 193 −67.476 −31.582 −24.892 1.00 17.29 C ATOM 10923 CG ARG B 193 −68.192 −30.318 −25.377 1.00 18.42 C ATOM 10926 CD ARG B 193 −69.664 −30.559 −25.646 1.00 19.63 C ATOM 10929 NE ARG B 193 −69.912 −31.592 −26.648 1.00 21.16 N ATOM 10931 CZ ARG B 193 −69.868 −31.398 −27.971 1.00 23.56 C ATOM 10932 NH1 ARG B 193 −69.575 −30.210 −28.496 1.00 23.37 N ATOM 10935 NH2 ARG B 193 −70.112 −32.413 −28.789 1.00 25.37 N ATOM 10938 C ARG B 193 −65.974 −30.658 −23.087 1.00 16.46 C ATOM 10939 O ARG B 193 −66.040 −31.323 −22.034 1.00 16.47 O ATOM 10941 N THR B 194 −65.864 −29.335 −23.078 1.00 15.84 N ATOM 10942 CA THR B 194 −65.886 −28.629 −21.799 1.00 15.67 C ATOM 10944 CB THR B 194 −65.354 −27.199 −21.884 1.00 15.48 C ATOM 10946 OG1 THR B 194 −66.077 −26.478 −22.882 1.00 15.55 O ATOM 10948 CG2 THR B 194 −63.877 −27.189 −22.211 1.00 14.65 C ATOM 10952 C THR B 194 −67.310 −28.613 −21.270 1.00 15.79 C ATOM 10953 O THR B 194 −68.264 −28.652 −22.030 1.00 15.73 O ATOM 10955 N GLN B 195 −67.444 −28.557 −19.957 1.00 16.20 N ATOM 10956 CA GLN B 195 −68.737 −28.711 −19.328 1.00 16.84 C ATOM 10958 CB GLN B 195 −68.601 −28.781 −17.816 1.00 17.07 C ATOM 10961 CG GLN B 195 −69.921 −28.440 −17.153 1.00 18.86 C ATOM 10964 CD GLN B 195 −69.999 −28.875 −15.746 1.00 20.95 C ATOM 10965 OE1 GLN B 195 −69.099 −29.511 −15.245 1.00 24.63 O ATOM 10966 NE2 GLN B 195 −71.071 −28.529 −15.082 1.00 22.36 N ATOM 10969 C GLN B 195 −69.757 −27.623 −19.669 1.00 16.93 C ATOM 10970 O GLN B 195 −70.858 −27.931 −20.136 1.00 16.98 O ATOM 10972 N ARG B 196 −69.430 −26.366 −19.386 1.00 16.92 N ATOM 10973 CA ARG B 196 −70.358 −25.301 −19.685 1.00 17.06 C ATOM 10975 CB ARG B 196 −69.719 −23.932 −19.459 1.00 17.00 C ATOM 10978 CG ARG B 196 −70.095 −23.289 −18.120 1.00 17.09 C ATOM 10981 CD ARG B 196 −70.283 −24.320 −16.995 1.00 17.56 C ATOM 10984 NE ARG B 196 −71.452 −24.043 −16.146 1.00 17.64 N ATOM 10986 CZ ARG B 196 −72.289 −24.965 −15.664 1.00 17.93 C ATOM 10987 NH1 ARG B 196 −72.136 −26.244 −15.966 1.00 17.72 N ATOM 10990 NH2 ARG B 196 −73.305 −24.611 −14.878 1.00 18.27 N ATOM 10993 C ARG B 196 −70.881 −25.481 −21.098 1.00 17.42 C ATOM 10994 O ARG B 196 −72.079 −25.519 −21.317 1.00 17.66 O ATOM 10996 N LEU B 197 −69.984 −25.676 −22.044 1.00 18.04 N ATOM 10997 CA LEU B 197 −70.379 −25.925 −23.425 1.00 18.51 C ATOM 10999 CB LEU B 197 −69.133 −26.085 −24.289 1.00 18.52 C ATOM 11002 CG LEU B 197 −68.998 −25.185 −25.508 1.00 18.06 C ATOM 11004 CD1 LEU B 197 −68.209 −23.932 −25.205 1.00 15.52 C ATOM 11008 CD2 LEU B 197 −68.293 −26.002 −26.574 1.00 20.21 C ATOM 11012 C LEU B 197 −71.290 −27.163 −23.580 1.00 19.14 C ATOM 11013 O LEU B 197 −72.226 −27.150 −24.372 1.00 19.52 O ATOM 11015 N GLU B 198 −71.030 −28.235 −22.842 1.00 19.72 N ATOM 11016 CA GLU B 198 −71.918 −29.396 −22.909 1.00 20.43 C ATOM 11018 CB GLU B 198 −71.272 −30.631 −22.270 1.00 20.65 C ATOM 11021 CG GLU B 198 −72.176 −31.880 −22.172 1.00 22.51 C ATOM 11024 CD GLU B 198 −72.635 −32.460 −23.522 1.00 25.57 C ATOM 11025 OE1 GLU B 198 −72.315 −31.896 −24.581 1.00 28.90 O ATOM 11026 OE2 GLU B 198 −73.326 −33.506 −23.540 1.00 28.09 O ATOM 11027 C GLU B 198 −73.271 −29.101 −22.259 1.00 20.72 C ATOM 11028 O GLU B 198 −74.281 −29.693 −22.644 1.00 20.82 O ATOM 11030 N ALA B 199 −73.282 −28.199 −21.270 1.00 20.86 N ATOM 11031 CA ALA B 199 −74.508 −27.814 −20.565 1.00 20.66 C ATOM 11033 CB ALA B 199 −74.176 −27.013 −19.326 1.00 20.36 C ATOM 11037 C ALA B 199 −75.472 −27.033 −21.461 1.00 20.84 C ATOM 11038 O ALA B 199 −76.644 −27.404 −21.590 1.00 20.84 O ATOM 11040 N VAL B 200 −75.002 −25.961 −22.092 1.00 21.12 N ATOM 11041 CA VAL B 200 −75.903 −25.177 −22.942 1.00 21.60 C ATOM 11043 CB VAL B 200 −75.215 −24.042 −23.701 1.00 21.30 C ATOM 11045 CG1 VAL B 200 −74.660 −23.055 −22.738 1.00 21.26 C ATOM 11049 CG2 VAL B 200 −74.135 −24.575 −24.626 1.00 21.28 C ATOM 11053 C VAL B 200 −76.603 −26.077 −23.944 1.00 22.32 C ATOM 11054 O VAL B 200 −77.791 −25.908 −24.218 1.00 22.32 O ATOM 11056 N TRP B 201 −75.872 −27.047 −24.472 1.00 23.16 N ATOM 11057 CA TRP B 201 −76.441 −27.946 −25.454 1.00 24.02 C ATOM 11059 CB TRP B 201 −75.348 −28.718 −26.195 1.00 24.36 C ATOM 11062 CG TRP B 201 −75.898 −29.510 −27.331 1.00 24.84 C ATOM 11063 CD1 TRP B 201 −76.060 −29.092 −28.613 1.00 25.41 C ATOM 11065 NE1 TRP B 201 −76.599 −30.094 −29.374 1.00 25.61 N ATOM 11067 CE2 TRP B 201 −76.807 −31.184 −28.579 1.00 25.34 C ATOM 11068 CD2 TRP B 201 −76.374 −30.847 −27.279 1.00 25.56 C ATOM 11069 CE3 TRP B 201 −76.466 −31.800 −26.264 1.00 27.13 C ATOM 11071 CZ3 TRP B 201 −76.989 −33.046 −26.574 1.00 28.66 C ATOM 11073 CH2 TRP B 201 −77.419 −33.347 −27.885 1.00 28.01 C ATOM 11075 CZ2 TRP B 201 −77.332 −32.425 −28.894 1.00 26.09 C ATOM 11077 C TRP B 201 −77.411 −28.938 −24.833 1.00 24.22 C ATOM 11078 O TRP B 201 −78.473 −29.172 −25.383 1.00 24.83 O ATOM 11080 N SER B 202 −77.034 −29.541 −23.715 1.00 24.39 N ATOM 11081 CA SER B 202 −77.818 −30.626 −23.144 1.00 24.50 C ATOM 11083 CB SER B 202 −76.968 −31.455 −22.184 1.00 24.42 C ATOM 11086 OG SER B 202 −75.848 −32.021 −22.848 1.00 23.80 O ATOM 11088 C SER B 202 −79.067 −30.099 −22.441 1.00 24.98 C ATOM 11089 O SER B 202 −80.057 −30.816 −22.324 1.00 24.73 O ATOM 11091 N ILE B 203 −79.032 −28.849 −21.982 1.00 25.60 N ATOM 11092 CA ILE B 203 −80.219 −28.255 −21.372 1.00 25.98 C ATOM 11094 CB ILE B 203 −79.908 −26.967 −20.591 1.00 25.85 C ATOM 11096 CG1 ILE B 203 −79.086 −27.326 −19.348 1.00 25.76 C ATOM 11099 CD1 ILE B 203 −78.779 −26.159 −18.431 1.00 26.28 C ATOM 11103 CG2 ILE B 203 −81.212 −26.253 −20.206 1.00 24.51 C ATOM 11107 C ILE B 203 −81.280 −28.016 −22.443 1.00 26.67 C ATOM 11108 O ILE B 203 −82.428 −28.398 −22.260 1.00 26.96 O ATOM 11110 N GLU B 204 −80.879 −27.412 −23.563 1.00 27.30 N ATOM 11111 CA GLU B 204 −81.758 −27.205 −24.720 1.00 27.49 C ATOM 11113 CB GLU B 204 −81.036 −26.384 −25.804 1.00 27.67 C ATOM 11116 CG GLU B 204 −81.849 −26.077 −27.073 1.00 28.50 C ATOM 11119 CD GLU B 204 −82.987 −25.072 −26.855 1.00 29.81 C ATOM 11120 OE1 GLU B 204 −83.158 −24.600 −25.711 1.00 31.40 O ATOM 11121 OE2 GLU B 204 −83.710 −24.750 −27.832 1.00 29.57 O ATOM 11122 C GLU B 204 −82.201 −28.542 −25.287 1.00 27.52 C ATOM 11123 O GLU B 204 −83.321 −28.667 −25.738 1.00 27.67 O ATOM 11125 N ALA B 205 −81.326 −29.539 −25.266 1.00 27.74 N ATOM 11126 CA ALA B 205 −81.684 −30.872 −25.728 1.00 28.09 C ATOM 11128 CB ALA B 205 −80.472 −31.789 −25.726 1.00 27.75 C ATOM 11132 C ALA B 205 −82.771 −31.448 −24.839 1.00 28.81 C ATOM 11133 O ALA B 205 −83.811 −31.877 −25.325 1.00 28.90 O ATOM 11135 N TYR B 206 −82.517 −31.433 −23.531 1.00 29.72 N ATOM 11136 CA TYR B 206 −83.408 −32.020 −22.527 1.00 30.30 C ATOM 11138 CB TYR B 206 −82.760 −31.915 −21.149 1.00 30.24 C ATOM 11141 CG TYR B 206 −83.276 −32.889 −20.127 1.00 29.79 C ATOM 11142 CD1 TYR B 206 −83.055 −34.245 −20.286 1.00 30.71 C ATOM 11144 CE1 TYR B 206 −83.498 −35.161 −19.360 1.00 30.78 C ATOM 11146 CZ TYR B 206 −84.159 −34.731 −18.238 1.00 30.03 C ATOM 11147 OH TYR B 206 −84.582 −35.684 −17.343 1.00 30.51 O ATOM 11149 CE2 TYR B 206 −84.394 −33.379 −18.042 1.00 29.42 C ATOM 11151 CD2 TYR B 206 −83.945 −32.463 −18.989 1.00 29.05 C ATOM 11153 C TYR B 206 −84.744 −31.308 −22.467 1.00 31.19 C ATOM 11154 O TYR B 206 −85.790 −31.930 −22.311 1.00 31.44 O ATOM 11156 N ARG B 207 −84.683 −29.988 −22.558 1.00 32.21 N ATOM 11157 CA ARG B 207 −85.853 −29.128 −22.521 1.00 33.04 C ATOM 11159 CB ARG B 207 −85.394 −27.700 −22.843 1.00 32.86 C ATOM 11162 CG ARG B 207 −86.441 −26.637 −22.846 1.00 32.82 C ATOM 11165 CD ARG B 207 −85.905 −25.360 −23.462 1.00 32.76 C ATOM 11168 NE ARG B 207 −85.148 −24.561 −22.504 1.00 32.80 N ATOM 11170 CZ ARG B 207 −85.676 −23.709 −21.628 1.00 33.40 C ATOM 11171 NH1 ARG B 207 −86.989 −23.526 −21.555 1.00 34.29 N ATOM 11174 NH2 ARG B 207 −84.884 −23.030 −20.808 1.00 33.89 N ATOM 11177 C ARG B 207 −86.971 −29.606 −23.478 1.00 34.14 C ATOM 11178 O ARG B 207 −88.144 −29.521 −23.128 1.00 34.34 O ATOM 11180 N LYS B 208 −86.607 −30.137 −24.652 1.00 35.32 N ATOM 11181 CA LYS B 208 −87.581 −30.535 −25.688 1.00 36.16 C ATOM 11183 CB LYS B 208 −86.960 −30.468 −27.090 1.00 36.01 C ATOM 11186 CG LYS B 208 −86.126 −29.234 −27.368 1.00 35.85 C ATOM 11189 CD LYS B 208 −85.934 −29.023 −28.861 1.00 35.98 C ATOM 11192 CE LYS B 208 −84.774 −28.086 −29.186 1.00 35.63 C ATOM 11195 NZ LYS B 208 −83.566 −28.843 −29.596 1.00 35.17 N ATOM 11199 C LYS B 208 −88.166 −31.937 −25.490 1.00 37.25 C ATOM 11200 O LYS B 208 −89.212 −32.250 −26.054 1.00 37.50 O ATOM 11202 N LYS B 209 −87.484 −32.788 −24.730 1.00 38.58 N ATOM 11203 CA LYS B 209 −88.026 −34.106 −24.383 1.00 39.89 C ATOM 11205 CB LYS B 209 −87.013 −34.923 −23.578 1.00 40.23 C ATOM 11208 CG LYS B 209 −85.914 −35.604 −24.373 1.00 41.47 C ATOM 11211 CD LYS B 209 −84.858 −36.178 −23.417 1.00 43.71 C ATOM 11214 CE LYS B 209 −84.448 −37.612 −23.764 1.00 45.15 C ATOM 11217 NZ LYS B 209 −85.390 −38.621 −23.163 1.00 45.73 N ATOM 11221 C LYS B 209 −89.288 −33.950 −23.530 1.00 40.51 C ATOM 11222 O LYS B 209 −89.230 −33.367 −22.441 1.00 40.84 O ATOM 11224 N GLU B 210 −90.418 −34.477 −24.000 1.00 40.92 N ATOM 11225 CA GLU B 210 −91.652 −34.386 −23.223 1.00 41.27 C ATOM 11227 CB GLU B 210 −92.855 −34.935 −23.998 1.00 41.77 C ATOM 11230 CG GLU B 210 −92.822 −36.446 −24.265 1.00 43.47 C ATOM 11233 CD GLU B 210 −94.049 −36.922 −25.032 1.00 45.23 C ATOM 11234 OE1 GLU B 210 −95.188 −36.590 −24.612 1.00 45.02 O ATOM 11235 OE2 GLU B 210 −93.863 −37.629 −26.053 1.00 46.74 O ATOM 11236 C GLU B 210 −91.494 −35.121 −21.895 1.00 40.71 C ATOM 11237 O GLU B 210 −91.996 −34.667 −20.864 1.00 40.99 O ATOM 11239 N ASP B 211 −90.773 −36.240 −21.924 1.00 39.76 N ATOM 11240 CA ASP B 211 −90.533 −37.050 −20.721 1.00 38.96 C ATOM 11242 CB ASP B 211 −90.151 −38.476 −21.123 1.00 39.10 C ATOM 11245 CG ASP B 211 −89.101 −38.499 −22.212 1.00 40.26 C ATOM 11246 OD1 ASP B 211 −89.327 −37.827 −23.254 1.00 41.25 O ATOM 11247 OD2 ASP B 211 −88.055 −39.160 −22.020 1.00 41.66 O ATOM 11248 C ASP B 211 −89.440 −36.468 −19.826 1.00 37.75 C ATOM 11249 O ASP B 211 −89.009 −37.131 −18.892 1.00 37.62 O ATOM 11251 N ALA B 212 −88.989 −35.245 −20.115 1.00 36.47 N ATOM 11252 CA ALA B 212 −87.941 −34.587 −19.335 1.00 35.36 C ATOM 11254 CB ALA B 212 −87.516 −33.294 −20.011 1.00 35.23 C ATOM 11258 C ALA B 212 −88.423 −34.307 −17.920 1.00 34.40 C ATOM 11259 O ALA B 212 −89.559 −33.870 −17.728 1.00 34.42 O ATOM 11261 N ASN B 213 −87.565 −34.574 −16.937 1.00 33.24 N ATOM 11262 CA ASN B 213 −87.890 −34.333 −15.533 1.00 32.67 C ATOM 11264 CB ASN B 213 −86.840 −34.986 −14.623 1.00 32.58 C ATOM 11267 CG ASN B 213 −87.204 −34.912 −13.152 1.00 32.67 C ATOM 11268 OD1 ASN B 213 −87.891 −33.994 −12.722 1.00 32.62 O ATOM 11269 ND2 ASN B 213 −86.734 −35.882 −12.371 1.00 33.18 N ATOM 11272 C ASN B 213 −87.990 −32.825 −15.266 1.00 32.19 C ATOM 11273 O ASN B 213 −87.010 −32.092 −15.376 1.00 32.38 O ATOM 11275 N GLN B 214 −89.182 −32.356 −14.923 1.00 31.48 N ATOM 11276 CA GLN B 214 −89.389 −30.924 −14.756 1.00 30.85 C ATOM 11278 CB GLN B 214 −90.889 −30.581 −14.693 1.00 30.82 C ATOM 11281 CG GLN B 214 −91.684 −30.869 −16.002 1.00 30.80 C ATOM 11284 CD GLN B 214 −90.990 −30.378 −17.291 1.00 29.69 C ATOM 11285 OE1 GLN B 214 −90.893 −29.174 −17.543 1.00 29.07 O ATOM 11286 NE2 GLN B 214 −90.526 −31.321 −18.113 1.00 27.71 N ATOM 11289 C GLN B 214 −88.638 −30.369 −13.543 1.00 30.37 C ATOM 11290 O GLN B 214 −88.263 −29.200 −13.533 1.00 30.80 O ATOM 11292 N VAL B 215 −88.393 −31.200 −12.532 1.00 29.54 N ATOM 11293 CA VAL B 215 −87.566 −30.779 −11.395 1.00 28.56 C ATOM 11295 CB VAL B 215 −87.564 −31.818 −10.260 1.00 28.64 C ATOM 11297 CG1 VAL B 215 −86.758 −31.299 −9.075 1.00 27.94 C ATOM 11301 CG2 VAL B 215 −88.999 −32.167 −9.856 1.00 28.26 C ATOM 11305 C VAL B 215 −86.124 −30.545 −11.845 1.00 27.63 C ATOM 11306 O VAL B 215 −85.566 −29.472 −11.615 1.00 27.58 O ATOM 11308 N LEU B 216 −85.546 −31.548 −12.504 1.00 26.37 N ATOM 11309 CA LEU B 216 −84.143 −31.509 −12.930 1.00 25.47 C ATOM 11311 CB LEU B 216 −83.714 −32.866 −13.490 1.00 25.46 C ATOM 11314 CG LEU B 216 −82.274 −32.995 −13.979 1.00 24.97 C ATOM 11316 CD1 LEU B 216 −81.289 −32.640 −12.883 1.00 24.62 C ATOM 11320 CD2 LEU B 216 −82.042 −34.407 −14.472 1.00 24.55 C ATOM 11324 C LEU B 216 −83.861 −30.447 −13.972 1.00 24.68 C ATOM 11325 O LEU B 216 −82.819 −29.820 −13.929 1.00 24.91 O ATOM 11327 N LEU B 217 −84.776 −30.269 −14.916 1.00 23.79 N ATOM 11328 CA LEU B 217 −84.625 −29.260 −15.960 1.00 23.13 C ATOM 11330 CB LEU B 217 −85.765 −29.384 −16.972 1.00 23.36 C ATOM 11333 CG LEU B 217 −85.808 −28.374 −18.123 1.00 23.18 C ATOM 11335 CD1 LEU B 217 −84.462 −28.268 −18.796 1.00 22.69 C ATOM 11339 CD2 LEU B 217 −86.861 −28.786 −19.126 1.00 23.38 C ATOM 11343 C LEU B 217 −84.631 −27.853 −15.383 1.00 22.51 C ATOM 11344 O LEU B 217 −83.903 −26.973 −15.855 1.00 22.08 O ATOM 11346 N GLU B 218 −85.481 −27.647 −14.375 1.00 21.84 N ATOM 11347 CA GLU B 218 −85.619 −26.339 −13.725 1.00 21.26 C ATOM 11349 CB GLU B 218 −86.813 −26.341 −12.768 1.00 21.27 C ATOM 11352 CG GLU B 218 −87.206 −24.956 −12.246 1.00 21.35 C ATOM 11355 CD GLU B 218 −88.501 −24.964 −11.441 1.00 20.89 C ATOM 11356 OE1 GLU B 218 −89.097 −26.052 −11.263 1.00 20.47 O ATOM 11357 OE2 GLU B 218 −88.915 −23.874 −10.986 1.00 20.15 O ATOM 11358 C GLU B 218 −84.348 −26.001 −12.969 1.00 20.58 C ATOM 11359 O GLU B 218 −83.877 −24.865 −12.982 1.00 20.31 O ATOM 11361 N LEU B 219 −83.802 −27.015 −12.312 1.00 19.87 N ATOM 11362 CA LEU B 219 −82.559 −26.885 −11.592 1.00 19.12 C ATOM 11364 CB LEU B 219 −82.310 −28.132 −10.746 1.00 18.58 C ATOM 11367 CG LEU B 219 −81.159 −28.054 −9.762 1.00 17.07 C ATOM 11369 CD1 LEU B 219 −81.321 −26.847 −8.872 1.00 16.10 C ATOM 11373 CD2 LEU B 219 −81.107 −29.311 −8.954 1.00 15.22 C ATOM 11377 C LEU B 219 −81.443 −26.675 −12.599 1.00 19.16 C ATOM 11378 O LEU B 219 −80.684 −25.721 −12.478 1.00 19.42 O ATOM 11380 N ALA B 220 −81.368 −27.546 −13.606 1.00 19.04 N ATOM 11381 CA ALA B 220 −80.356 −27.431 −14.669 1.00 19.04 C ATOM 11383 CB ALA B 220 −80.648 −28.398 −15.817 1.00 18.64 C ATOM 11387 C ALA B 220 −80.257 −26.004 −15.196 1.00 19.06 C ATOM 11388 O ALA B 220 −79.159 −25.472 −15.321 1.00 19.08 O ATOM 11390 N ILE B 221 −81.410 −25.393 −15.475 1.00 19.19 N ATOM 11391 CA ILE B 221 −81.473 −24.016 −15.963 1.00 19.22 C ATOM 11393 CB ILE B 221 −82.898 −23.638 −16.423 1.00 19.03 C ATOM 11395 CG1 ILE B 221 −83.229 −24.323 −17.755 1.00 18.52 C ATOM 11398 CD1 ILE B 221 −84.687 −24.645 −17.928 1.00 17.52 C ATOM 11402 CG2 ILE B 221 −83.024 −22.121 −16.564 1.00 18.03 C ATOM 11406 C ILE B 221 −81.030 −23.013 −14.906 1.00 19.62 C ATOM 11407 O ILE B 221 −80.137 −22.190 −15.136 1.00 19.53 O ATOM 11409 N LEU B 222 −81.666 −23.096 −13.745 1.00 20.27 N ATOM 11410 CA LEU B 222 −81.412 −22.161 −12.654 1.00 20.63 C ATOM 11412 CB LEU B 222 −82.203 −22.561 −11.412 1.00 20.50 C ATOM 11415 CG LEU B 222 −82.195 −21.523 −10.296 1.00 20.76 C ATOM 11417 CD1 LEU B 222 −83.439 −21.675 −9.431 1.00 21.02 C ATOM 11421 CD2 LEU B 222 −80.924 −21.625 −9.453 1.00 20.21 C ATOM 11425 C LEU B 222 −79.925 −22.089 −12.341 1.00 20.98 C ATOM 11426 O LEU B 222 −79.337 −21.011 −12.381 1.00 21.40 O ATOM 11428 N ASP B 223 −79.319 −23.240 −12.064 1.00 21.24 N ATOM 11429 CA ASP B 223 −77.907 −23.298 −11.709 1.00 21.48 C ATOM 11431 CB ASP B 223 −77.509 −24.724 −11.314 1.00 21.66 C ATOM 11434 CG ASP B 223 −76.168 −24.792 −10.589 1.00 22.70 C ATOM 11435 OD1 ASP B 223 −75.095 −24.775 −11.244 1.00 24.25 O ATOM 11436 OD2 ASP B 223 −76.190 −24.893 −9.349 1.00 24.85 O ATOM 11437 C ASP B 223 −77.017 −22.768 −12.835 1.00 21.64 C ATOM 11438 O ASP B 223 −76.035 −22.104 −12.548 1.00 21.66 O ATOM 11440 N TYR B 224 −77.361 −23.023 −14.100 1.00 22.07 N ATOM 11441 CA TYR B 224 −76.517 −22.561 −15.218 1.00 22.47 C ATOM 11443 CB TYR B 224 −76.980 −23.111 −16.589 1.00 22.35 C ATOM 11446 CG TYR B 224 −76.032 −22.733 −17.724 1.00 22.25 C ATOM 11447 CD1 TYR B 224 −75.002 −23.576 −18.116 1.00 21.46 C ATOM 11449 CE1 TYR B 224 −74.126 −23.216 −19.135 1.00 21.43 C ATOM 11451 CZ TYR B 224 −74.260 −21.991 −19.761 1.00 21.62 C ATOM 11452 OH TYR B 224 −73.387 −21.618 −20.760 1.00 20.46 O ATOM 11454 CE2 TYR B 224 −75.270 −21.132 −19.387 1.00 22.04 C ATOM 11456 CD2 TYR B 224 −76.144 −21.500 −18.373 1.00 22.73 C ATOM 11458 C TYR B 224 −76.414 −21.023 −15.262 1.00 23.06 C ATOM 11459 O TYR B 224 −75.323 −20.467 −15.507 1.00 22.89 O ATOM 11461 N ASN B 225 −77.543 −20.350 −15.027 1.00 23.66 N ATOM 11462 CA ASN B 225 −77.593 −18.884 −15.072 1.00 24.16 C ATOM 11464 CB ASN B 225 −79.040 −18.367 −15.107 1.00 24.12 C ATOM 11467 CG ASN B 225 −79.778 −18.761 −16.365 1.00 23.89 C ATOM 11468 OD1 ASN B 225 −79.182 −18.877 −17.437 1.00 24.33 O ATOM 11469 ND2 ASN B 225 −81.088 −18.965 −16.244 1.00 22.05 N ATOM 11472 C ASN B 225 −76.880 −18.265 −13.881 1.00 24.73 C ATOM 11473 O ASN B 225 −76.195 −17.247 −14.027 1.00 25.09 O ATOM 11475 N MET B 226 −77.067 −18.864 −12.703 1.00 25.15 N ATOM 11476 CA MET B 226 −76.423 −18.390 −11.479 1.00 25.53 C ATOM 11478 CB MET B 226 −76.806 −19.278 −10.282 1.00 26.11 C ATOM 11481 CG MET B 226 −75.905 −19.169 −9.023 1.00 27.59 C ATOM 11484 SD MET B 226 −75.676 −20.788 −8.214 1.00 30.67 S ATOM 11485 CE MET B 226 −77.308 −21.005 −7.476 1.00 29.78 C ATOM 11489 C MET B 226 −74.920 −18.380 −11.692 1.00 25.16 C ATOM 11490 O MET B 226 −74.258 −17.387 −11.391 1.00 25.10 O ATOM 11492 N ILE B 227 −74.388 −19.473 −12.239 1.00 24.88 N ATOM 11493 CA ILE B 227 −72.944 −19.564 −12.501 1.00 24.70 C ATOM 11495 CB ILE B 227 −72.476 −20.994 −12.882 1.00 24.45 C ATOM 11497 CG1 ILE B 227 −72.656 −21.947 −11.695 1.00 23.80 C ATOM 11500 CD1 ILE B 227 −72.094 −23.332 −11.885 1.00 21.97 C ATOM 11504 CG2 ILE B 227 −71.030 −20.969 −13.266 1.00 24.90 C ATOM 11508 C ILE B 227 −72.529 −18.550 −13.566 1.00 24.45 C ATOM 11509 O ILE B 227 −71.578 −17.810 −13.373 1.00 24.42 O ATOM 11511 N GLN B 228 −73.264 −18.484 −14.668 1.00 24.31 N ATOM 11512 CA GLN B 228 −73.038 −17.414 −15.639 1.00 24.19 C ATOM 11514 CB GLN B 228 −74.143 −17.363 −16.688 1.00 24.02 C ATOM 11517 CG GLN B 228 −73.788 −16.488 −17.864 1.00 23.42 C ATOM 11520 CD GLN B 228 −74.807 −16.567 −18.983 1.00 23.70 C ATOM 11521 OE1 GLN B 228 −75.790 −15.813 −19.015 1.00 24.07 O ATOM 11522 NE2 GLN B 228 −74.564 −17.465 −19.927 1.00 23.49 N ATOM 11525 C GLN B 228 −72.913 −16.037 −14.987 1.00 24.37 C ATOM 11526 O GLN B 228 −72.145 −15.210 −15.470 1.00 24.45 O ATOM 11528 N SER B 229 −73.653 −15.776 −13.909 1.00 24.45 N ATOM 11529 CA SER B 229 −73.578 −14.459 −13.264 1.00 24.76 C ATOM 11531 CB SER B 229 −74.815 −14.163 −12.397 1.00 24.84 C ATOM 11534 OG SER B 229 −74.711 −14.718 −11.096 1.00 25.81 O ATOM 11536 C SER B 229 −72.270 −14.279 −12.469 1.00 24.64 C ATOM 11537 O SER B 229 −71.726 −13.172 −12.408 1.00 24.95 O ATOM 11539 N VAL B 230 −71.751 −15.350 −11.878 1.00 24.20 N ATOM 11540 CA VAL B 230 −70.415 −15.277 −11.299 1.00 23.99 C ATOM 11542 CB VAL B 230 −70.006 −16.581 −10.574 1.00 23.92 C ATOM 11544 CG1 VAL B 230 −68.546 −16.510 −10.105 1.00 23.71 C ATOM 11548 CG2 VAL B 230 −70.923 −16.853 −9.409 1.00 23.52 C ATOM 11552 C VAL B 230 −69.386 −14.966 −12.400 1.00 24.12 C ATOM 11553 O VAL B 230 −68.397 −14.291 −12.136 1.00 24.01 O ATOM 11555 N TYR B 231 −69.612 −15.461 −13.621 1.00 24.30 N ATOM 11556 CA TYR B 231 −68.672 −15.235 −14.728 1.00 24.53 C ATOM 11558 CB TYR B 231 −68.997 −16.104 −15.946 1.00 24.08 C ATOM 11561 CG TYR B 231 −68.892 −17.605 −15.754 1.00 23.29 C ATOM 11562 CD1 TYR B 231 −68.173 −18.168 −14.706 1.00 23.08 C ATOM 11564 CE1 TYR B 231 −68.073 −19.547 −14.565 1.00 22.01 C ATOM 11566 CZ TYR B 231 −68.685 −20.369 −15.479 1.00 21.16 C ATOM 11567 OH TYR B 231 −68.607 −21.746 −15.353 1.00 20.18 O ATOM 11569 CE2 TYR B 231 −69.387 −19.825 −16.523 1.00 21.64 C ATOM 11571 CD2 TYR B 231 −69.476 −18.464 −16.662 1.00 22.15 C ATOM 11573 C TYR B 231 −68.658 −13.772 −15.166 1.00 25.37 C ATOM 11574 O TYR B 231 −67.602 −13.221 −15.528 1.00 25.25 O ATOM 11576 N GLN B 232 −69.832 −13.148 −15.129 1.00 26.11 N ATOM 11577 CA GLN B 232 −69.978 −11.797 −15.622 1.00 26.68 C ATOM 11579 CB GLN B 232 −71.430 −11.541 −15.995 1.00 26.45 C ATOM 11582 CG GLN B 232 −71.883 −12.385 −17.176 1.00 25.67 C ATOM 11585 CD GLN B 232 −73.388 −12.394 −17.381 1.00 24.91 C ATOM 11586 OE1 GLN B 232 −74.140 −11.761 −16.637 1.00 24.81 O ATOM 11587 NE2 GLN B 232 −73.834 −13.113 −18.407 1.00 23.39 N ATOM 11590 C GLN B 232 −69.445 −10.802 −14.593 1.00 27.90 C ATOM 11591 O GLN B 232 −68.909 −9.752 −14.958 1.00 27.96 O ATOM 11593 N ARG B 233 −69.572 −11.145 −13.312 1.00 29.35 N ATOM 11594 CA ARG B 233 −68.908 −10.396 −12.241 1.00 30.59 C ATOM 11596 CB ARG B 233 −69.490 −10.775 −10.867 1.00 30.99 C ATOM 11599 CG ARG B 233 −68.824 −10.114 −9.661 1.00 32.72 C ATOM 11602 CD ARG B 233 −69.695 −10.210 −8.391 1.00 35.70 C ATOM 11605 NE ARG B 233 −70.162 −11.578 −8.086 1.00 38.29 N ATOM 11607 CZ ARG B 233 −71.403 −12.053 −8.276 1.00 39.65 C ATOM 11608 NH1 ARG B 233 −72.367 −11.287 −8.787 1.00 40.23 N ATOM 11611 NH2 ARG B 233 −71.687 −13.320 −7.949 1.00 39.61 N ATOM 11614 C ARG B 233 −67.390 −10.632 −12.303 1.00 31.10 C ATOM 11615 O ARG B 233 −66.615 −9.693 −12.181 1.00 31.19 O ATOM 11617 N ASP B 234 −66.954 −11.868 −12.517 1.00 31.91 N ATOM 11618 CA ASP B 234 −65.530 −12.102 −12.750 1.00 32.63 C ATOM 11620 CB ASP B 234 −65.220 −13.566 −13.090 1.00 32.53 C ATOM 11623 CG ASP B 234 −65.336 −14.493 −11.894 1.00 32.90 C ATOM 11624 OD1 ASP B 234 −65.477 −14.028 −10.746 1.00 33.06 O ATOM 11625 OD2 ASP B 234 −65.293 −15.713 −12.107 1.00 34.22 O ATOM 11626 C ASP B 234 −65.058 −11.206 −13.886 1.00 33.10 C ATOM 11627 O ASP B 234 −64.097 −10.458 −13.723 1.00 33.55 O ATOM 11629 N LEU B 235 −65.753 −11.256 −15.017 1.00 33.49 N ATOM 11630 CA LEU B 235 −65.311 −10.550 −16.216 1.00 34.06 C ATOM 11632 CB LEU B 235 −66.139 −10.996 −17.422 1.00 33.80 C ATOM 11635 CG LEU B 235 −65.769 −10.403 −18.775 1.00 32.13 C ATOM 11637 CD1 LEU B 235 −64.303 −10.679 −19.050 1.00 30.94 C ATOM 11641 CD2 LEU B 235 −66.670 −10.959 −19.870 1.00 29.93 C ATOM 11645 C LEU B 235 −65.345 −9.023 −16.103 1.00 35.40 C ATOM 11646 O LEU B 235 −64.500 −8.352 −16.682 1.00 35.61 O ATOM 11648 N ARG B 236 −66.327 −8.473 −15.386 1.00 36.92 N ATOM 11649 CA ARG B 236 −66.380 −7.019 −15.137 1.00 38.06 C ATOM 11651 CB ARG B 236 −67.650 −6.607 −14.367 1.00 38.43 C ATOM 11654 CG ARG B 236 −68.882 −6.321 −15.230 1.00 39.58 C ATOM 11657 CD ARG B 236 −69.958 −5.520 −14.459 1.00 40.93 C ATOM 11660 NE ARG B 236 −70.383 −6.149 −13.199 1.00 41.74 N ATOM 11662 CZ ARG B 236 −71.208 −7.195 −13.095 1.00 42.20 C ATOM 11663 NH1 ARG B 236 −71.719 −7.784 −14.175 1.00 41.61 N ATOM 11666 NH2 ARG B 236 −71.517 −7.672 −11.892 1.00 42.99 N ATOM 11669 C ARG B 236 −65.170 −6.550 −14.343 1.00 38.57 C ATOM 11670 O ARG B 236 −64.593 −5.524 −14.665 1.00 38.61 O ATOM 11672 N GLU B 237 −64.822 −7.292 −13.291 1.00 39.42 N ATOM 11673 CA GLU B 237 −63.625 −7.017 −12.480 1.00 40.18 C ATOM 11675 CB GLU B 237 −63.471 −8.033 −11.317 1.00 40.67 C ATOM 11678 CG GLU B 237 −64.336 −7.750 −10.057 1.00 42.61 C ATOM 11681 CD GLU B 237 −64.258 −8.858 −8.961 1.00 45.07 C ATOM 11682 OE1 GLU B 237 −64.051 −10.066 −9.282 1.00 46.74 O ATOM 11683 OE2 GLU B 237 −64.436 −8.511 −7.764 1.00 45.87 O ATOM 11684 C GLU B 237 −62.352 −7.024 −13.344 1.00 39.93 C ATOM 11685 O GLU B 237 −61.593 −6.050 −13.332 1.00 39.96 O ATOM 11687 N THR B 238 −62.123 −8.104 −14.095 1.00 39.56 N ATOM 11688 CA THR B 238 −60.900 −8.200 −14.895 1.00 39.42 C ATOM 11690 CB THR B 238 −60.492 −9.666 −15.268 1.00 39.39 C ATOM 11692 OG1 THR B 238 −61.222 −10.123 −16.413 1.00 39.37 O ATOM 11694 CG2 THR B 238 −60.683 −10.612 −14.095 1.00 38.73 C ATOM 11698 C THR B 238 −60.961 −7.326 −16.156 1.00 39.48 C ATOM 11699 O THR B 238 −59.930 −7.062 −16.761 1.00 39.48 O ATOM 11701 N SER B 239 −62.149 −6.871 −16.549 1.00 39.62 N ATOM 11702 CA SER B 239 −62.264 −5.882 −17.631 1.00 39.63 C ATOM 11704 CB SER B 239 −63.689 −5.810 −18.172 1.00 39.56 C ATOM 11707 OG SER B 239 −63.945 −6.917 −19.010 1.00 38.96 O ATOM 11709 C SER B 239 −61.796 −4.496 −17.181 1.00 39.99 C ATOM 11710 O SER B 239 −61.108 −3.807 −17.933 1.00 40.10 O ATOM 11712 N ARG B 240 −62.168 −4.088 −15.965 1.00 40.35 N ATOM 11713 CA ARG B 240 −61.624 −2.864 −15.363 1.00 40.68 C ATOM 11715 CB ARG B 240 −62.025 −2.712 −13.881 1.00 41.26 C ATOM 11718 CG ARG B 240 −63.231 −1.782 −13.621 1.00 43.86 C ATOM 11721 CD ARG B 240 −63.334 −1.375 −12.130 1.00 47.07 C ATOM 11724 NE ARG B 240 −63.365 −2.537 −11.222 1.00 50.14 N ATOM 11726 CZ ARG B 240 −64.462 −3.077 −10.671 1.00 52.32 C ATOM 11727 NH1 ARG B 240 −64.342 −4.141 −9.875 1.00 53.16 N ATOM 11730 NH2 ARG B 240 −65.677 −2.577 −10.899 1.00 53.18 N ATOM 11733 C ARG B 240 −60.113 −2.914 −15.464 1.00 39.91 C ATOM 11734 O ARG B 240 −59.490 −2.000 −15.988 1.00 39.86 O ATOM 11736 N TRP B 241 −59.541 −4.002 −14.962 1.00 39.14 N ATOM 11737 CA TRP B 241 −58.105 −4.217 −15.004 1.00 38.37 C ATOM 11739 CB TRP B 241 −57.773 −5.635 −14.521 1.00 38.17 C ATOM 11742 CG TRP B 241 −56.373 −6.005 −14.773 1.00 36.58 C ATOM 11743 CD1 TRP B 241 −55.290 −5.668 −14.022 1.00 36.32 C ATOM 11745 NE1 TRP B 241 −54.152 −6.176 −14.587 1.00 35.63 N ATOM 11747 CE2 TRP B 241 −54.494 −6.846 −15.731 1.00 34.31 C ATOM 11748 CD2 TRP B 241 −55.883 −6.757 −15.874 1.00 33.99 C ATOM 11749 CE3 TRP B 241 −56.484 −7.357 −16.977 1.00 33.28 C ATOM 11751 CZ3 TRP B 241 −55.691 −8.034 −17.883 1.00 32.79 C ATOM 11753 CH2 TRP B 241 −54.313 −8.101 −17.720 1.00 33.06 C ATOM 11755 CZ2 TRP B 241 −53.697 −7.515 −16.648 1.00 34.16 C ATOM 11757 C TRP B 241 −57.561 −3.999 −16.409 1.00 38.25 C ATOM 11758 O TRP B 241 −56.607 −3.252 −16.603 1.00 38.13 O ATOM 11760 N TRP B 242 −58.186 −4.644 −17.386 1.00 38.21 N ATOM 11761 CA TRP B 242 −57.695 −4.628 −18.765 1.00 38.27 C ATOM 11763 CB TRP B 242 −58.479 −5.640 −19.609 1.00 38.31 C ATOM 11766 CG TRP B 242 −57.948 −5.872 −20.990 1.00 38.61 C ATOM 11767 CD1 TRP B 242 −58.642 −5.754 −22.156 1.00 39.11 C ATOM 11769 NE1 TRP B 242 −57.828 −6.046 −23.224 1.00 39.31 N ATOM 11771 CE2 TRP B 242 −56.582 −6.363 −22.759 1.00 38.95 C ATOM 11772 CD2 TRP B 242 −56.617 −6.263 −21.356 1.00 38.66 C ATOM 11773 CE3 TRP B 242 −55.454 −6.528 −20.637 1.00 38.98 C ATOM 11775 CZ3 TRP B 242 −54.314 −6.886 −21.326 1.00 39.20 C ATOM 11777 CH2 TRP B 242 −54.313 −6.985 −22.716 1.00 39.12 C ATOM 11779 CZ2 TRP B 242 −55.434 −6.724 −23.451 1.00 39.22 C ATOM 11781 C TRP B 242 −57.739 −3.241 −19.400 1.00 38.27 C ATOM 11782 O TRP B 242 −56.814 −2.873 −20.108 1.00 37.81 O ATOM 11784 N ARG B 243 −58.809 −2.489 −19.140 1.00 38.79 N ATOM 11785 CA ARG B 243 −58.936 −1.097 −19.607 1.00 39.37 C ATOM 11787 CB ARG B 243 −60.351 −.552 −19.346 1.00 39.66 C ATOM 11790 CG ARG B 243 −61.324 −.792 −20.520 1.00 41.96 C ATOM 11793 CD ARG B 243 −62.687 −1.338 −20.085 1.00 44.82 C ATOM 11796 NE ARG B 243 −63.461 −.380 −19.296 1.00 47.15 N ATOM 11798 CZ ARG B 243 −64.389 −.704 −18.386 1.00 49.26 C ATOM 11799 NH1 ARG B 243 −64.685 −1.976 −18.109 1.00 49.18 N ATOM 11802 NH2 ARG B 243 −65.028 .262 −17.729 1.00 50.40 N ATOM 11805 C ARG B 243 −57.890 −.183 −18.980 1.00 39.28 C ATOM 11806 O ARG B 243 −57.246 .577 −19.681 1.00 39.40 O ATOM 11808 N ARG B 244 −57.724 −.282 −17.665 1.00 39.52 N ATOM 11809 CA ARG B 244 −56.734 .489 −16.888 1.00 39.61 C ATOM 11811 CB ARG B 244 −56.774 .041 −15.409 1.00 40.25 C ATOM 11814 CG ARG B 244 −56.115 .971 −14.383 1.00 42.01 C ATOM 11817 CD ARG B 244 −57.029 2.154 −14.017 1.00 44.39 C ATOM 11820 NE ARG B 244 −56.391 3.115 −13.103 1.00 46.36 N ATOM 11822 CZ ARG B 244 −55.434 3.984 −13.441 1.00 48.06 C ATOM 11823 NH1 ARG B 244 −54.951 4.043 −14.686 1.00 48.90 N ATOM 11826 NH2 ARG B 244 −54.947 4.805 −12.519 1.00 48.82 N ATOM 11829 C ARG B 244 −55.323 .322 −17.437 1.00 38.83 C ATOM 11830 O ARG B 244 −54.594 1.300 −17.567 1.00 38.39 O ATOM 11832 N VAL B 245 −54.953 −.922 −17.738 1.00 38.52 N ATOM 11833 CA VAL B 245 −53.694 −1.241 −18.437 1.00 38.43 C ATOM 11835 CB VAL B 245 −53.491 −2.760 −18.614 1.00 38.31 C ATOM 11837 CG1 VAL B 245 −53.247 −3.426 −17.283 1.00 37.77 C ATOM 11841 CG2 VAL B 245 −52.344 −3.036 −19.561 1.00 37.66 C ATOM 11845 C VAL B 245 −53.650 −.638 −19.832 1.00 38.68 C ATOM 11846 O VAL B 245 −52.615 −.153 −20.247 1.00 38.57 O ATOM 11848 N GLY B 246 −54.765 −.724 −20.559 1.00 39.26 N ATOM 11849 CA GLY B 246 −54.974 −.012 −21.834 1.00 39.62 C ATOM 11852 C GLY B 246 −53.962 −.262 −22.942 1.00 40.08 C ATOM 11853 O GLY B 246 −53.617 .650 −23.700 1.00 39.89 O ATOM 11855 N LEU B 247 −53.502 −1.500 −23.062 1.00 40.75 N ATOM 11856 CA LEU B 247 −52.347 −1.778 −23.905 1.00 41.34 C ATOM 11858 CB LEU B 247 −51.655 −3.065 −23.459 1.00 41.15 C ATOM 11861 CG LEU B 247 −50.132 −3.026 −23.298 1.00 40.49 C ATOM 11863 CD1 LEU B 247 −49.622 −1.769 −22.605 1.00 39.50 C ATOM 11867 CD2 LEU B 247 −49.695 −4.242 −22.526 1.00 39.98 C ATOM 11871 C LEU B 247 −52.744 −1.836 −25.370 1.00 42.50 C ATOM 11872 O LEU B 247 −52.005 −1.358 −26.225 1.00 42.33 O ATOM 11874 N ALA B 248 −53.925 −2.390 −25.654 1.00 44.14 N ATOM 11875 CA ALA B 248 −54.439 −2.494 −27.041 1.00 45.16 C ATOM 11877 CB ALA B 248 −55.705 −3.347 −27.087 1.00 45.15 C ATOM 11881 C ALA B 248 −54.692 −1.140 −27.739 1.00 45.98 C ATOM 11882 O ALA B 248 −54.604 −1.053 −28.971 1.00 46.37 O ATOM 11884 N THR B 249 −55.004 −.095 −26.975 1.00 46.64 N ATOM 11885 CA THR B 249 −55.142 1.234 −27.570 1.00 47.25 C ATOM 11887 CB THR B 249 −55.905 2.253 −26.655 1.00 47.44 C ATOM 11889 OG1 THR B 249 −55.001 2.845 −25.706 1.00 47.52 O ATOM 11891 CG2 THR B 249 −57.104 1.592 −25.928 1.00 47.44 C ATOM 11895 C THR B 249 −53.756 1.793 −27.931 1.00 47.59 C ATOM 11896 O THR B 249 −53.553 2.279 −29.049 1.00 48.07 O ATOM 11898 N LYS B 250 −52.808 1.710 −26.995 1.00 47.67 N ATOM 11899 CA LYS B 250 −51.469 2.299 −27.185 1.00 47.68 C ATOM 11901 CB LYS B 250 −50.793 2.553 −25.833 1.00 47.68 C ATOM 11904 CG LYS B 250 −51.428 3.673 −24.999 1.00 47.77 C ATOM 11907 CD LYS B 250 −51.142 5.086 −25.552 1.00 47.59 C ATOM 11910 CE LYS B 250 −49.676 5.496 −25.441 1.00 46.75 C ATOM 11913 NZ LYS B 250 −49.479 6.878 −25.948 1.00 46.49 N ATOM 11917 C LYS B 250 −50.541 1.465 −28.082 1.00 47.72 C ATOM 11918 O LYS B 250 −49.591 1.988 −28.663 1.00 47.54 O ATOM 11920 N LEU B 251 −50.804 .169 −28.184 1.00 47.82 N ATOM 11921 CA LEU B 251 −50.072 −.675 −29.118 1.00 47.96 C ATOM 11923 CB LEU B 251 −49.584 −1.970 −28.447 1.00 48.04 C ATOM 11926 CG LEU B 251 −48.109 −2.064 −28.033 1.00 47.39 C ATOM 11928 CD1 LEU B 251 −47.659 −.881 −27.186 1.00 46.47 C ATOM 11932 CD2 LEU B 251 −47.894 −3.376 −27.304 1.00 46.78 C ATOM 11936 C LEU B 251 −50.985 −.964 −30.306 1.00 48.19 C ATOM 11937 O LEU B 251 −51.975 −1.693 −30.194 1.00 48.38 O ATOM 11939 N HIS B 252 −50.627 −.396 −31.449 1.00 48.42 N ATOM 11940 CA HIS B 252 −51.521 −.329 −32.601 1.00 48.62 C ATOM 11942 CB HIS B 252 −51.110 .850 −33.492 1.00 48.99 C ATOM 11945 CG HIS B 252 −51.000 2.145 −32.742 1.00 50.56 C ATOM 11946 ND1 HIS B 252 −52.095 2.935 −32.453 1.00 52.11 N ATOM 11948 CE1 HIS B 252 −51.704 3.993 −31.766 1.00 52.68 C ATOM 11950 NE2 HIS B 252 −50.397 3.912 −31.585 1.00 52.86 N ATOM 11952 CD2 HIS B 252 −49.932 2.764 −32.181 1.00 51.68 C ATOM 11954 C HIS B 252 −51.582 −1.636 −33.383 1.00 48.14 C ATOM 11955 O HIS B 252 −52.615 −1.975 −33.935 1.00 48.02 O ATOM 11957 N PHE B 253 −50.481 −2.372 −33.405 1.00 48.10 N ATOM 11958 CA PHE B 253 −50.422 −3.702 −34.044 1.00 48.18 C ATOM 11960 CB PHE B 253 −48.965 −4.070 −34.375 1.00 48.16 C ATOM 11963 CG PHE B 253 −48.119 −4.311 −33.163 1.00 47.85 C ATOM 11964 CD1 PHE B 253 −47.900 −5.596 −32.702 1.00 48.56 C ATOM 11966 CE1 PHE B 253 −47.140 −5.812 −31.576 1.00 48.98 C ATOM 11968 CZ PHE B 253 −46.602 −4.729 −30.895 1.00 48.50 C ATOM 11970 CE2 PHE B 253 −46.817 −3.454 −31.349 1.00 47.40 C ATOM 11972 CD2 PHE B 253 −47.569 −3.249 −32.465 1.00 47.22 C ATOM 11974 C PHE B 253 −51.038 −4.819 −33.185 1.00 48.30 C ATOM 11975 O PHE B 253 −51.344 −5.903 −33.691 1.00 47.63 O ATOM 11977 N ALA B 254 −51.204 −4.541 −31.888 1.00 48.86 N ATOM 11978 CA ALA B 254 −51.653 −5.531 −30.903 1.00 49.13 C ATOM 11980 CB ALA B 254 −51.290 −5.071 −29.494 1.00 49.02 C ATOM 11984 C ALA B 254 −53.153 −5.806 −30.982 1.00 49.46 C ATOM 11985 O ALA B 254 −53.967 −4.870 −31.011 1.00 49.50 O ATOM 11987 N ARG B 255 −53.501 −7.097 −31.006 1.00 49.75 N ATOM 11988 CA ARG B 255 −54.896 −7.549 −30.918 1.00 49.89 C ATOM 11990 CB ARG B 255 −55.028 −9.051 −31.245 1.00 49.94 C ATOM 11993 CG ARG B 255 −54.839 −9.439 −32.724 1.00 49.93 C ATOM 11996 CD ARG B 255 −54.709 −10.967 −32.904 1.00 49.79 C ATOM 11999 NE ARG B 255 −53.527 −11.505 −32.219 1.00 50.11 N ATOM 12001 CZ ARG B 255 −53.276 −12.801 −32.010 1.00 50.54 C ATOM 12002 NH1 ARG B 255 −54.117 −13.736 −32.439 1.00 51.36 N ATOM 12005 NH2 ARG B 255 −52.175 −13.172 −31.360 1.00 50.21 N ATOM 12008 C ARG B 255 −55.425 −7.308 −29.511 1.00 49.83 C ATOM 12009 O ARG B 255 −54.666 −6.975 −28.599 1.00 49.95 O ATOM 12011 N ASP B 256 −56.736 −7.463 −29.350 1.00 49.72 N ATOM 12012 CA ASP B 256 −57.360 −7.483 −28.034 1.00 49.55 C ATOM 12014 CB ASP B 256 −58.183 −6.222 −27.812 1.00 49.52 C ATOM 12017 CG ASP B 256 −59.134 −6.362 −26.654 1.00 50.30 C ATOM 12018 OD1 ASP B 256 −60.310 −5.944 −26.780 1.00 50.45 O ATOM 12019 OD2 ASP B 256 −58.702 −6.926 −25.622 1.00 51.68 O ATOM 12020 C ASP B 256 −58.254 −8.721 −27.931 1.00 49.15 C ATOM 12021 O ASP B 256 −59.159 −8.901 −28.737 1.00 49.28 O ATOM 12023 N ARG B 257 −57.998 −9.565 −26.937 1.00 48.61 N ATOM 12024 CA ARG B 257 −58.743 −10.809 −26.765 1.00 48.20 C ATOM 12026 CB ARG B 257 −57.949 −11.984 −27.373 1.00 48.41 C ATOM 12029 CG ARG B 257 −57.505 −11.799 −28.821 1.00 49.37 C ATOM 12032 CD ARG B 257 −58.693 −11.636 −29.784 1.00 50.80 C ATOM 12035 NE ARG B 257 −58.908 −12.814 −30.627 1.00 52.11 N ATOM 12037 CZ ARG B 257 −58.678 −12.876 −31.944 1.00 52.99 C ATOM 12038 NH1 ARG B 257 −58.214 −11.820 −32.623 1.00 52.37 N ATOM 12041 NH2 ARG B 257 −58.918 −14.016 −32.596 1.00 52.97 N ATOM 12044 C ARG B 257 −59.032 −11.089 −25.280 1.00 47.32 C ATOM 12045 O ARG B 257 −58.579 −12.101 −24.735 1.00 47.46 O ATOM 12047 N LEU B 258 −59.770 −10.201 −24.616 1.00 45.94 N ATOM 12048 CA LEU B 258 −60.108 −10.430 −23.205 1.00 44.67 C ATOM 12050 CB LEU B 258 −60.332 −9.130 −22.438 1.00 44.61 C ATOM 12053 CG LEU B 258 −60.422 −9.323 −20.920 1.00 43.83 C ATOM 12055 CD1 LEU B 258 −59.045 −9.552 −20.339 1.00 43.48 C ATOM 12059 CD2 LEU B 258 −61.073 −8.139 −20.262 1.00 43.85 C ATOM 12063 C LEU B 258 −61.347 −11.286 −23.090 1.00 43.49 C ATOM 12064 O LEU B 258 −61.375 −12.220 −22.295 1.00 43.84 O ATOM 12066 N ILE B 259 −62.364 −10.968 −23.883 1.00 41.92 N ATOM 12067 CA ILE B 259 −63.617 −11.711 −23.841 1.00 40.80 C ATOM 12069 CB ILE B 259 −64.718 −11.132 −24.783 1.00 41.05 C ATOM 12071 CG1 ILE B 259 −64.852 −9.598 −24.653 1.00 41.61 C ATOM 12074 CD1 ILE B 259 −65.200 −8.874 −25.985 1.00 42.16 C ATOM 12078 CG2 ILE B 259 −66.065 −11.816 −24.496 1.00 40.46 C ATOM 12082 C ILE B 259 −63.319 −13.151 −24.250 1.00 39.50 C ATOM 12083 O ILE B 259 −63.782 −14.082 −23.598 1.00 39.30 O ATOM 12085 N GLU B 260 −62.524 −13.318 −25.316 1.00 37.99 N ATOM 12086 CA GLU B 260 −62.120 −14.652 −25.812 1.00 36.60 C ATOM 12088 CB GLU B 260 −61.329 −14.574 −27.142 1.00 36.75 C ATOM 12091 CG GLU B 260 −62.167 −14.319 −28.425 1.00 37.79 C ATOM 12094 CD GLU B 260 −62.134 −12.851 −28.905 1.00 39.47 C ATOM 12095 OE1 GLU B 260 −62.207 −11.923 −28.055 1.00 39.97 O ATOM 12096 OE2 GLU B 260 −62.033 −12.628 −30.139 1.00 40.31 O ATOM 12097 C GLU B 260 −61.282 −15.381 −24.770 1.00 34.83 C ATOM 12098 O GLU B 260 −61.465 −16.568 −24.544 1.00 34.69 O ATOM 12100 N SER B 261 −60.365 −14.669 −24.131 1.00 32.89 N ATOM 12101 CA SER B 261 −59.508 −15.292 −23.139 1.00 31.48 C ATOM 12103 CB SER B 261 −58.341 −14.376 −22.768 1.00 31.55 C ATOM 12106 OG SER B 261 −57.298 −14.493 −23.728 1.00 31.75 O ATOM 12108 C SER B 261 −60.294 −15.716 −21.900 1.00 30.04 C ATOM 12109 O SER B 261 −59.921 −16.674 −21.208 1.00 29.70 O ATOM 12111 N PHE B 262 −61.389 −15.021 −21.618 1.00 28.25 N ATOM 12112 CA PHE B 262 −62.203 −15.404 −20.480 1.00 26.75 C ATOM 12114 CB PHE B 262 −63.111 −14.278 −20.009 1.00 26.36 C ATOM 12117 CG PHE B 262 −63.532 −14.453 −18.603 1.00 24.33 C ATOM 12118 CD1 PHE B 262 −62.697 −14.092 −17.584 1.00 22.66 C ATOM 12120 CE1 PHE B 262 −63.047 −14.283 −16.301 1.00 22.65 C ATOM 12122 CZ PHE B 262 −64.245 −14.873 −16.007 1.00 23.93 C ATOM 12124 CE2 PHE B 262 −65.076 −15.267 −17.010 1.00 24.08 C ATOM 12126 CD2 PHE B 262 −64.711 −15.067 −18.304 1.00 23.96 C ATOM 12128 C PHE B 262 −63.017 −16.660 −20.751 1.00 26.02 C ATOM 12129 O PHE B 262 −63.074 −17.546 −19.909 1.00 26.32 O ATOM 12131 N TYR B 263 −63.652 −16.732 −21.915 1.00 24.98 N ATOM 12132 CA TYR B 263 −64.299 −17.969 −22.396 1.00 24.14 C ATOM 12134 CB TYR B 263 −64.701 −17.756 −23.853 1.00 24.00 C ATOM 12137 CG TYR B 263 −65.080 −18.961 −24.667 1.00 24.32 C ATOM 12138 CD1 TYR B 263 −66.302 −19.604 −24.489 1.00 25.03 C ATOM 12140 CE1 TYR B 263 −66.666 −20.694 −25.285 1.00 25.81 C ATOM 12142 CZ TYR B 263 −65.798 −21.132 −26.287 1.00 27.06 C ATOM 12143 OH TYR B 263 −66.106 −22.191 −27.123 1.00 27.14 O ATOM 12145 CE2 TYR B 263 −64.590 −20.489 −26.479 1.00 26.80 C ATOM 12147 CD2 TYR B 263 −64.250 −19.404 −25.680 1.00 25.65 C ATOM 12149 C TYR B 263 −63.351 −19.162 −22.256 1.00 23.35 C ATOM 12150 O TYR B 263 −63.712 −20.219 −21.740 1.00 22.80 O ATOM 12152 N TRP B 264 −62.119 −18.955 −22.702 1.00 22.64 N ATOM 12153 CA TRP B 264 −61.047 −19.918 −22.523 1.00 21.95 C ATOM 12155 CB TRP B 264 −59.737 −19.334 −23.061 1.00 21.84 C ATOM 12158 CG TRP B 264 −58.603 −20.278 −22.964 1.00 22.90 C ATOM 12159 CD1 TRP B 264 −57.700 −20.387 −21.943 1.00 23.98 C ATOM 12161 NE1 TRP B 264 −56.800 −21.386 −22.214 1.00 23.95 N ATOM 12163 CE2 TRP B 264 −57.124 −21.949 −23.417 1.00 23.51 C ATOM 12164 CD2 TRP B 264 −58.252 −21.273 −23.915 1.00 23.40 C ATOM 12165 CE3 TRP B 264 −58.776 −21.652 −25.147 1.00 23.68 C ATOM 12167 CZ3 TRP B 264 −58.178 −22.669 −25.826 1.00 24.44 C ATOM 12169 CH2 TRP B 264 −57.060 −23.324 −25.310 1.00 24.97 C ATOM 12171 CZ2 TRP B 264 −56.521 −22.978 −24.103 1.00 24.44 C ATOM 12173 C TRP B 264 −60.897 −20.326 −21.050 1.00 21.11 C ATOM 12174 O TRP B 264 −60.768 −21.511 −20.748 1.00 20.98 O ATOM 12176 N ALA B 265 −60.916 −19.344 −20.147 1.00 20.17 N ATOM 12177 CA ALA B 265 −60.774 −19.602 −18.712 1.00 19.36 C ATOM 12179 CB ALA B 265 −60.621 −18.305 −17.944 1.00 19.30 C ATOM 12183 C ALA B 265 −61.947 −20.397 −18.171 1.00 18.63 C ATOM 12184 O ALA B 265 −61.763 −21.349 −17.434 1.00 18.64 O ATOM 12186 N VAL B 266 −63.159 −20.034 −18.557 1.00 18.11 N ATOM 12187 CA VAL B 266 −64.335 −20.758 −18.075 1.00 17.60 C ATOM 12189 CB VAL B 266 −65.652 −20.221 −18.675 1.00 17.38 C ATOM 12191 CG1 VAL B 266 −65.902 −18.803 −18.199 1.00 17.09 C ATOM 12195 CG2 VAL B 266 −66.817 −21.120 −18.312 1.00 15.40 C ATOM 12199 C VAL B 266 −64.221 −22.246 −18.376 1.00 17.67 C ATOM 12200 O VAL B 266 −64.766 −23.058 −17.647 1.00 18.27 O ATOM 12202 N GLY B 267 −63.516 −22.607 −19.444 1.00 17.43 N ATOM 12203 CA GLY B 267 −63.316 −24.013 −19.789 1.00 16.98 C ATOM 12206 C GLY B 267 −62.253 −24.683 −18.947 1.00 16.55 C ATOM 12207 O GLY B 267 −62.360 −25.859 −18.609 1.00 16.37 O ATOM 12209 N VAL B 268 −61.215 −23.939 −18.608 1.00 16.30 N ATOM 12210 CA VAL B 268 −60.160 −24.500 −17.794 1.00 16.23 C ATOM 12212 CB VAL B 268 −58.893 −23.651 −17.840 1.00 15.68 C ATOM 12214 CG1 VAL B 268 −57.857 −24.194 −16.894 1.00 15.01 C ATOM 12218 CG2 VAL B 268 −58.361 −23.674 −19.235 1.00 15.01 C ATOM 12222 C VAL B 268 −60.654 −24.718 −16.374 1.00 16.86 C ATOM 12223 O VAL B 268 −60.421 −25.784 −15.813 1.00 16.93 O ATOM 12225 N ALA B 269 −61.362 −23.733 −15.817 1.00 17.64 N ATOM 12226 CA ALA B 269 −61.911 −23.838 −14.461 1.00 18.46 C ATOM 12228 CB ALA B 269 −60.958 −23.215 −13.472 1.00 18.15 C ATOM 12232 C ALA B 269 −63.312 −23.213 −14.340 1.00 19.34 C ATOM 12233 O ALA B 269 −63.448 −22.030 −14.047 1.00 19.78 O ATOM 12235 N PHE B 270 −64.347 −24.028 −14.529 1.00 20.34 N ATOM 12236 CA PHE B 270 −65.724 −23.535 −14.631 1.00 21.21 C ATOM 12238 CB PHE B 270 −66.564 −24.483 −15.482 1.00 21.34 C ATOM 12241 CG PHE B 270 −67.083 −25.667 −14.718 1.00 22.46 C ATOM 12242 CD1 PHE B 270 −68.294 −25.596 −14.039 1.00 23.19 C ATOM 12244 CE1 PHE B 270 −68.756 −26.672 −13.315 1.00 23.27 C ATOM 12246 CZ PHE B 270 −68.003 −27.836 −13.258 1.00 23.35 C ATOM 12248 CE2 PHE B 270 −66.794 −27.918 −13.932 1.00 22.73 C ATOM 12250 CD2 PHE B 270 −66.340 −26.843 −14.646 1.00 22.88 C ATOM 12252 C PHE B 270 −66.464 −23.366 −13.316 1.00 21.98 C ATOM 12253 O PHE B 270 −67.408 −22.583 −13.268 1.00 21.93 O ATOM 12255 N GLU B 271 −66.102 −24.126 −12.275 1.00 23.01 N ATOM 12256 CA GLU B 271 −66.929 −24.142 −11.037 1.00 23.99 C ATOM 12258 CB GLU B 271 −66.679 −25.353 −10.113 1.00 24.25 C ATOM 12261 CG GLU B 271 −65.286 −25.877 −10.092 1.00 26.22 C ATOM 12264 CD GLU B 271 −65.013 −26.914 −11.183 1.00 29.01 C ATOM 12265 OE1 GLU B 271 −65.563 −28.032 −11.090 1.00 31.36 O ATOM 12266 OE2 GLU B 271 −64.232 −26.622 −12.121 1.00 30.98 O ATOM 12267 C GLU B 271 −66.795 −22.831 −10.281 1.00 23.90 C ATOM 12268 O GLU B 271 −65.702 −22.296 −10.181 1.00 24.29 O ATOM 12270 N PRO B 272 −67.913 −22.316 −9.745 1.00 24.09 N ATOM 12271 CA PRO B 272 −68.005 −20.885 −9.428 1.00 24.11 C ATOM 12273 CB PRO B 272 −69.380 −20.751 −8.751 1.00 24.03 C ATOM 12276 CG PRO B 272 −70.083 −22.069 −8.997 1.00 24.12 C ATOM 12279 CD PRO B 272 −69.013 −23.083 −9.132 1.00 23.99 C ATOM 12282 C PRO B 272 −66.900 −20.386 −8.501 1.00 24.28 C ATOM 12283 O PRO B 272 −66.421 −19.261 −8.676 1.00 24.40 O ATOM 12284 N GLN B 273 −66.480 −21.222 −7.547 1.00 24.20 N ATOM 12285 CA GLN B 273 −65.500 −20.809 −6.551 1.00 24.20 C ATOM 12287 CB GLN B 273 −65.437 −21.840 −5.426 1.00 24.42 C ATOM 12290 CG GLN B 273 −64.750 −23.176 −5.775 1.00 25.17 C ATOM 12293 CD GLN B 273 −65.717 −24.334 −6.007 1.00 26.13 C ATOM 12294 OE1 GLN B 273 −66.857 −24.141 −6.453 1.00 27.46 O ATOM 12295 NE2 GLN B 273 −65.251 −25.554 −5.721 1.00 25.05 N ATOM 12298 C GLN B 273 −64.086 −20.546 −7.088 1.00 24.27 C ATOM 12299 O GLN B 273 −63.221 −20.151 −6.329 1.00 24.32 O ATOM 12301 N TYR B 274 −63.842 −20.759 −8.380 1.00 24.59 N ATOM 12302 CA TYR B 274 −62.509 −20.551 −8.962 1.00 24.85 C ATOM 12304 CB TYR B 274 −62.129 −21.724 −9.880 1.00 24.62 C ATOM 12307 CG TYR B 274 −62.009 −23.054 −9.184 1.00 24.35 C ATOM 12308 CD1 TYR B 274 −61.395 −23.169 −7.946 1.00 24.62 C ATOM 12310 CE1 TYR B 274 −61.280 −24.391 −7.314 1.00 25.10 C ATOM 12312 CZ TYR B 274 −61.771 −25.525 −7.920 1.00 24.92 C ATOM 12313 OH TYR B 274 −61.661 −26.748 −7.299 1.00 24.73 O ATOM 12315 CE2 TYR B 274 −62.366 −25.437 −9.150 1.00 24.76 C ATOM 12317 CD2 TYR B 274 −62.477 −24.203 −9.779 1.00 24.70 C ATOM 12319 C TYR B 274 −62.409 −19.235 −9.745 1.00 25.27 C ATOM 12320 O TYR B 274 −61.956 −19.210 −10.895 1.00 25.42 O ATOM 12322 N SER B 275 −62.808 −18.134 −9.121 1.00 25.40 N ATOM 12323 CA SER B 275 −62.755 −16.849 −9.802 1.00 25.43 C ATOM 12325 CB SER B 275 −63.615 −15.814 −9.071 1.00 25.53 C ATOM 12328 OG SER B 275 −65.006 −16.068 −9.291 1.00 25.52 O ATOM 12330 C SER B 275 −61.300 −16.403 −9.948 1.00 25.36 C ATOM 12331 O SER B 275 −60.885 −15.903 −10.996 1.00 25.17 O ATOM 12333 N ASP B 276 −60.517 −16.617 −8.901 1.00 25.41 N ATOM 12334 CA ASP B 276 −59.095 −16.353 −8.979 1.00 25.42 C ATOM 12336 CB ASP B 276 −58.390 −16.794 −7.712 1.00 25.44 C ATOM 12339 CG ASP B 276 −58.728 −15.925 −6.558 1.00 26.32 C ATOM 12340 OD1 ASP B 276 −59.302 −14.857 −6.818 1.00 27.50 O ATOM 12341 OD2 ASP B 276 −58.442 −16.299 −5.398 1.00 30.16 O ATOM 12342 C ASP B 276 −58.495 −17.069 −10.157 1.00 25.20 C ATOM 12343 O ASP B 276 −57.745 −16.461 −10.929 1.00 25.66 O ATOM 12345 N CYS B 277 −58.814 −18.353 −10.305 1.00 24.60 N ATOM 12346 CA CYS B 277 −58.228 −19.110 −11.391 1.00 24.30 C ATOM 12348 CB CYS B 277 −58.684 −20.561 −11.392 1.00 24.28 C ATOM 12351 SG CYS B 277 −57.737 −21.574 −12.569 1.00 23.82 S ATOM 12353 C CYS B 277 −58.593 −18.448 −12.698 1.00 24.09 C ATOM 12354 O CYS B 277 −57.727 −18.013 −13.450 1.00 23.87 O ATOM 12356 N ARG B 278 −59.893 −18.329 −12.933 1.00 24.22 N ATOM 12357 CA ARG B 278 −60.400 −17.746 −14.171 1.00 23.98 C ATOM 12359 CB ARG B 278 −61.917 −17.556 −14.123 1.00 23.93 C ATOM 12362 CG ARG B 278 −62.662 −18.871 −14.283 1.00 24.07 C ATOM 12365 CD ARG B 278 −64.132 −18.670 −14.607 1.00 24.48 C ATOM 12368 NE ARG B 278 −64.874 −18.141 −13.472 1.00 23.75 N ATOM 12370 CZ ARG B 278 −65.254 −18.856 −12.419 1.00 23.72 C ATOM 12371 NH1 ARG B 278 −64.973 −20.149 −12.326 1.00 22.86 N ATOM 12374 NH2 ARG B 278 −65.927 −18.262 −11.443 1.00 25.08 N ATOM 12377 C ARG B 278 −59.701 −16.453 −14.491 1.00 23.56 C ATOM 12378 O ARG B 278 −59.296 −16.265 −15.628 1.00 23.87 O ATOM 12380 N ASN B 279 −59.512 −15.593 −13.495 1.00 23.24 N ATOM 12381 CA ASN B 279 −58.854 −14.301 −13.734 1.00 23.48 C ATOM 12383 CB ASN B 279 −59.055 −13.340 −12.574 1.00 24.05 C ATOM 12386 CG ASN B 279 −60.510 −13.017 −12.346 1.00 26.58 C ATOM 12387 OD1 ASN B 279 −61.378 −13.310 −13.189 1.00 28.96 O ATOM 12388 ND2 ASN B 279 −60.799 −12.416 −11.194 1.00 30.30 N ATOM 12391 C ASN B 279 −57.376 −14.404 −14.027 1.00 22.58 C ATOM 12392 O ASN B 279 −56.903 −13.749 −14.941 1.00 22.73 O ATOM 12394 N SER B 280 −56.648 −15.205 −13.251 1.00 21.62 N ATOM 12395 CA SER B 280 −55.243 −15.483 −13.550 1.00 20.73 C ATOM 12397 CB SER B 280 −54.696 −16.597 −12.659 1.00 20.85 C ATOM 12400 OG SER B 280 −53.805 −16.099 −11.683 1.00 21.55 O ATOM 12402 C SER B 280 −55.091 −15.896 −15.004 1.00 20.04 C ATOM 12403 O SER B 280 −54.293 −15.312 −15.738 1.00 19.87 O ATOM 12405 N VAL B 281 −55.875 −16.893 −15.413 1.00 19.24 N ATOM 12406 CA VAL B 281 −55.720 −17.491 −16.720 1.00 18.77 C ATOM 12408 CB VAL B 281 −56.482 −18.834 −16.815 1.00 18.74 C ATOM 12410 CG1 VAL B 281 −56.467 −19.404 −18.251 1.00 18.34 C ATOM 12414 CG2 VAL B 281 −55.863 −19.844 −15.848 1.00 18.13 C ATOM 12418 C VAL B 281 −56.142 −16.486 −17.787 1.00 18.89 C ATOM 12419 O VAL B 281 −55.483 −16.364 −18.832 1.00 18.75 O ATOM 12421 N ALA B 282 −57.210 −15.739 −17.505 1.00 18.85 N ATOM 12422 CA ALA B 282 −57.709 −14.723 −18.439 1.00 18.80 C ATOM 12424 CB ALA B 282 −59.051 −14.191 −17.991 1.00 18.32 C ATOM 12428 C ALA B 282 −56.718 −13.576 −18.615 1.00 18.94 C ATOM 12429 O ALA B 282 −56.582 −13.021 −19.700 1.00 19.16 O ATOM 12431 N LYS B 283 −56.022 −13.211 −17.553 1.00 19.24 N ATOM 12432 CA LYS B 283 −55.037 −12.145 −17.658 1.00 19.62 C ATOM 12434 CB LYS B 283 −54.649 −11.615 −16.276 1.00 19.68 C ATOM 12437 CG LYS B 283 −55.779 −10.923 −15.518 1.00 19.95 C ATOM 12440 CD LYS B 283 −55.265 −10.398 −14.196 1.00 21.72 C ATOM 12443 CE LYS B 283 −56.364 −10.236 −13.164 1.00 23.83 C ATOM 12446 NZ LYS B 283 −56.129 −9.003 −12.351 1.00 24.72 N ATOM 12450 C LYS B 283 −53.802 −12.643 −18.396 1.00 19.77 C ATOM 12451 O LYS B 283 −53.237 −11.929 −19.208 1.00 20.05 O ATOM 12453 N MET B 284 −53.387 −13.871 −18.117 1.00 19.88 N ATOM 12454 CA MET B 284 −52.136 −14.367 −18.652 1.00 19.90 C ATOM 12456 CB MET B 284 −51.719 −15.676 −17.960 1.00 20.08 C ATOM 12459 CG MET B 284 −51.125 −15.505 −16.560 1.00 20.62 C ATOM 12462 SD MET B 284 −49.782 −14.295 −16.485 1.00 23.69 S ATOM 12463 CE MET B 284 −50.600 −12.872 −15.754 1.00 23.82 C ATOM 12467 C MET B 284 −52.257 −14.572 −20.145 1.00 19.82 C ATOM 12468 O MET B 284 −51.326 −14.269 −20.889 1.00 20.21 O ATOM 12470 N PHE B 285 −53.401 −15.088 −20.579 1.00 19.72 N ATOM 12471 CA PHE B 285 −53.620 −15.428 −21.986 1.00 19.66 C ATOM 12473 CB PHE B 285 −54.863 −16.324 −22.114 1.00 20.09 C ATOM 12476 CG PHE B 285 −54.986 −17.077 −23.427 1.00 21.18 C ATOM 12477 CD1 PHE B 285 −53.877 −17.362 −24.232 1.00 22.86 C ATOM 12479 CE1 PHE B 285 −54.013 −18.070 −25.424 1.00 22.58 C ATOM 12481 CZ PHE B 285 −55.254 −18.518 −25.806 1.00 23.49 C ATOM 12483 CE2 PHE B 285 −56.365 −18.254 −25.002 1.00 23.36 C ATOM 12485 CD2 PHE B 285 −56.222 −17.551 −23.823 1.00 21.76 C ATOM 12487 C PHE B 285 −53.781 −14.148 −22.781 1.00 19.18 C ATOM 12488 O PHE B 285 −53.333 −14.046 −23.914 1.00 18.98 O ATOM 12490 N SER B 286 −54.410 −13.161 −22.164 1.00 18.92 N ATOM 12491 CA SER B 286 −54.488 −11.843 −22.753 1.00 19.15 C ATOM 12493 CB SER B 286 −55.292 −10.894 −21.863 1.00 19.38 C ATOM 12496 OG SER B 286 −56.684 −11.180 −21.957 1.00 20.24 O ATOM 12498 C SER B 286 −53.106 −11.267 −23.032 1.00 18.91 C ATOM 12499 O SER B 286 −52.894 −10.668 −24.087 1.00 19.48 O ATOM 12501 N PHE B 287 −52.172 −11.446 −22.102 1.00 18.48 N ATOM 12502 CA PHE B 287 −50.768 −11.065 −22.339 1.00 18.30 C ATOM 12504 CB PHE B 287 −49.958 −11.035 −21.044 1.00 18.27 C ATOM 12507 CG PHE B 287 −50.040 −9.740 −20.324 1.00 18.59 C ATOM 12508 CD1 PHE B 287 −49.375 −8.624 −20.813 1.00 20.02 C ATOM 12510 CE1 PHE B 287 −49.456 −7.410 −20.152 1.00 20.57 C ATOM 12512 CZ PHE B 287 −50.208 −7.308 −18.985 1.00 20.02 C ATOM 12514 CE2 PHE B 287 −50.869 −8.417 −18.503 1.00 19.78 C ATOM 12516 CD2 PHE B 287 −50.781 −9.623 −19.164 1.00 19.05 C ATOM 12518 C PHE B 287 −50.067 −11.978 −23.339 1.00 18.01 C ATOM 12519 O PHE B 287 −49.374 −11.498 −24.229 1.00 18.00 O ATOM 12521 N VAL B 288 −50.236 −13.286 −23.194 1.00 17.69 N ATOM 12522 CA VAL B 288 −49.720 −14.206 −24.197 1.00 17.66 C ATOM 12524 CB VAL B 288 −50.168 −15.649 −23.930 1.00 17.37 C ATOM 12526 CG1 VAL B 288 −49.937 −16.529 −25.134 1.00 16.24 C ATOM 12530 CG2 VAL B 288 −49.414 −16.185 −22.758 1.00 17.21 C ATOM 12534 C VAL B 288 −50.081 −13.761 −25.633 1.00 18.08 C ATOM 12535 O VAL B 288 −49.207 −13.710 −26.492 1.00 18.08 O ATOM 12537 N THR B 289 −51.327 −13.396 −25.895 1.00 18.42 N ATOM 12538 CA THR B 289 −51.683 −13.001 −27.256 1.00 19.33 C ATOM 12540 CB THR B 289 −53.171 −12.736 −27.401 1.00 19.35 C ATOM 12542 OG1 THR B 289 −53.573 −11.895 −26.321 1.00 21.59 O ATOM 12544 CG2 THR B 289 −53.973 −14.046 −27.350 1.00 19.09 C ATOM 12548 C THR B 289 −50.901 −11.766 −27.723 1.00 19.71 C ATOM 12549 O THR B 289 −50.469 −11.707 −28.891 1.00 19.88 O ATOM 12551 N ILE B 290 −50.689 −10.796 −26.829 1.00 19.94 N ATOM 12552 CA ILE B 290 −49.943 −9.585 −27.225 1.00 20.39 C ATOM 12554 CB ILE B 290 −50.069 −8.410 −26.221 1.00 20.50 C ATOM 12556 CG1 ILE B 290 −51.510 −8.137 −25.823 1.00 21.25 C ATOM 12559 CD1 ILE B 290 −51.650 −6.854 −25.002 1.00 21.58 C ATOM 12563 CG2 ILE B 290 −49.546 −7.134 −26.853 1.00 20.39 C ATOM 12567 C ILE B 290 −48.434 −9.840 −27.438 1.00 20.45 C ATOM 12568 O ILE B 290 −47.853 −9.317 −28.393 1.00 20.76 O ATOM 12570 N ILE B 291 −47.808 −10.616 −26.546 1.00 20.21 N ATOM 12571 CA ILE B 291 −46.375 −10.869 −26.618 1.00 19.87 C ATOM 12573 CB ILE B 291 −45.840 −11.603 −25.407 1.00 19.79 C ATOM 12575 CG1 ILE B 291 −46.205 −10.879 −24.102 1.00 19.71 C ATOM 12578 CD1 ILE B 291 −45.326 −9.734 −23.748 1.00 19.77 C ATOM 12582 CG2 ILE B 291 −44.336 −11.747 −25.516 1.00 18.91 C ATOM 12586 C ILE B 291 −46.134 −11.735 −27.825 1.00 20.44 C ATOM 12587 O ILE B 291 −45.233 −11.481 −28.600 1.00 20.35 O ATOM 12589 N ASP B 292 −46.965 −12.751 −28.005 1.00 21.33 N ATOM 12590 CA ASP B 292 −46.915 −13.563 −29.228 1.00 22.13 C ATOM 12592 CB ASP B 292 −48.120 −14.508 −29.316 1.00 22.40 C ATOM 12595 CG ASP B 292 −47.847 −15.741 −30.160 1.00 23.47 C ATOM 12596 OD1 ASP B 292 −46.852 −15.765 −30.923 1.00 24.83 O ATOM 12597 OD2 ASP B 292 −48.637 −16.707 −30.038 1.00 25.22 O ATOM 12598 C ASP B 292 −46.856 −12.716 −30.507 1.00 22.28 C ATOM 12599 O ASP B 292 −46.088 −13.033 −31.399 1.00 22.73 O ATOM 12601 N ASP B 293 −47.656 −11.658 −30.611 1.00 22.22 N ATOM 12602 CA ASP B 293 −47.630 −10.828 −31.822 1.00 22.43 C ATOM 12604 CB ASP B 293 −48.840 −9.894 −31.885 1.00 23.03 C ATOM 12607 CG ASP B 293 −50.157 −10.644 −31.959 1.00 24.69 C ATOM 12608 OD1 ASP B 293 −50.113 −11.900 −32.025 1.00 28.66 O ATOM 12609 OD2 ASP B 293 −51.231 −9.986 −31.930 1.00 23.57 O ATOM 12610 C ASP B 293 −46.354 −9.997 −31.921 1.00 21.94 C ATOM 12611 O ASP B 293 −45.898 −9.674 −33.019 1.00 22.31 O ATOM 12613 N ILE B 294 −45.783 −9.643 −30.780 1.00 21.05 N ATOM 12614 CA ILE B 294 −44.513 −8.941 −30.770 1.00 20.53 C ATOM 12616 CB ILE B 294 −44.166 −8.448 −29.344 1.00 20.42 C ATOM 12618 CG1 ILE B 294 −45.150 −7.349 −28.945 1.00 19.66 C ATOM 12621 CD1 ILE B 294 −45.057 −6.956 −27.536 1.00 18.81 C ATOM 12625 CG2 ILE B 294 −42.726 −7.924 −29.253 1.00 19.99 C ATOM 12629 C ILE B 294 −43.416 −9.845 −31.343 1.00 20.44 C ATOM 12630 O ILE B 294 −42.650 −9.431 −32.205 1.00 20.17 O ATOM 12632 N TYR B 295 −43.355 −11.088 −30.886 1.00 20.65 N ATOM 12633 CA TYR B 295 −42.313 −12.008 −31.353 1.00 20.76 C ATOM 12635 CB TYR B 295 −42.145 −13.198 −30.412 1.00 20.29 C ATOM 12638 CG TYR B 295 −41.393 −12.926 −29.129 1.00 17.92 C ATOM 12639 CD1 TYR B 295 −40.117 −13.409 −28.936 1.00 17.62 C ATOM 12641 CE1 TYR B 295 −39.427 −13.195 −27.747 1.00 17.12 C ATOM 12643 CZ TYR B 295 −40.022 −12.493 −26.730 1.00 16.61 C ATOM 12644 OH TYR B 295 −39.357 −12.281 −25.528 1.00 14.46 O ATOM 12646 CE2 TYR B 295 −41.296 −12.008 −26.911 1.00 16.82 C ATOM 12648 CD2 TYR B 295 −41.972 −12.235 −28.102 1.00 16.39 C ATOM 12650 C TYR B 295 −42.619 −12.519 −32.749 1.00 21.65 C ATOM 12651 O TYR B 295 −41.698 −12.751 −33.540 1.00 22.13 O ATOM 12653 N ASP B 296 −43.905 −12.677 −33.049 1.00 22.47 N ATOM 12654 CA ASP B 296 −44.327 −13.316 −34.285 1.00 23.52 C ATOM 12656 CB ASP B 296 −45.761 −13.851 −34.185 1.00 23.99 C ATOM 12659 CG ASP B 296 −46.134 −14.744 −35.369 1.00 26.22 C ATOM 12660 OD1 ASP B 296 −45.508 −15.832 −35.538 1.00 27.70 O ATOM 12661 OD2 ASP B 296 −47.052 −14.348 −36.128 1.00 28.78 O ATOM 12662 C ASP B 296 −44.228 −12.392 −35.478 1.00 23.68 C ATOM 12663 O ASP B 296 −43.673 −12.784 −36.502 1.00 24.01 O ATOM 12665 N VAL B 297 −44.765 −11.178 −35.364 1.00 23.90 N ATOM 12666 CA VAL B 297 −44.801 −10.273 −36.524 1.00 23.99 C ATOM 12668 CB VAL B 297 −46.251 −10.003 −36.973 1.00 23.87 C ATOM 12670 CG1 VAL B 297 −46.949 −11.310 −37.197 1.00 23.75 C ATOM 12674 CG2 VAL B 297 −47.002 −9.136 −35.966 1.00 23.05 C ATOM 12678 C VAL B 297 −44.060 −8.940 −36.383 1.00 24.27 C ATOM 12679 O VAL B 297 −43.485 −8.465 −37.342 1.00 23.84 O ATOM 12681 N TYR B 298 −44.058 −8.347 −35.199 1.00 24.87 N ATOM 12682 CA TYR B 298 −43.760 −6.926 −35.078 1.00 25.67 C ATOM 12684 CB TYR B 298 −44.656 −6.294 −34.010 1.00 26.06 C ATOM 12687 CG TYR B 298 −44.520 −4.789 −33.932 1.00 27.95 C ATOM 12688 CD1 TYR B 298 −45.097 −3.968 −34.901 1.00 29.74 C ATOM 12690 CE1 TYR B 298 −44.982 −2.574 −34.843 1.00 29.93 C ATOM 12692 CZ TYR B 298 −44.282 −1.991 −33.806 1.00 29.96 C ATOM 12693 OH TYR B 298 −44.165 −.631 −33.746 1.00 30.01 O ATOM 12695 CE2 TYR B 298 −43.697 −2.777 −32.829 1.00 30.39 C ATOM 12697 CD2 TYR B 298 −43.811 −4.181 −32.899 1.00 29.96 C ATOM 12699 C TYR B 298 −42.318 −6.592 −34.755 1.00 25.76 C ATOM 12700 O TYR B 298 −41.696 −5.830 −35.470 1.00 26.54 O ATOM 12702 N GLY B 299 −41.798 −7.111 −33.653 1.00 25.89 N ATOM 12703 CA GLY B 299 −40.473 −6.706 −33.167 1.00 25.78 C ATOM 12706 C GLY B 299 −39.346 −7.341 −33.951 1.00 25.52 C ATOM 12707 O GLY B 299 −39.513 −8.410 −34.525 1.00 26.04 O ATOM 12709 N THR B 300 −38.196 −6.685 −33.990 1.00 25.32 N ATOM 12710 CA THR B 300 −37.063 −7.237 −34.716 1.00 25.16 C ATOM 12712 CB THR B 300 −36.088 −6.164 −35.295 1.00 25.08 C ATOM 12714 OG1 THR B 300 −35.191 −5.710 −34.281 1.00 25.07 O ATOM 12716 CG2 THR B 300 −36.833 −4.978 −35.875 1.00 25.08 C ATOM 12720 C THR B 300 −36.324 −8.139 −33.771 1.00 25.13 C ATOM 12721 O THR B 300 −36.335 −7.950 −32.570 1.00 25.28 O ATOM 12723 N LEU B 301 −35.662 −9.129 −34.332 1.00 25.50 N ATOM 12724 CA LEU B 301 −34.918 −10.093 −33.538 1.00 25.42 C ATOM 12726 CB LEU B 301 −34.148 −11.020 −34.479 1.00 25.17 C ATOM 12729 CG LEU B 301 −33.624 −12.338 −33.941 1.00 24.95 C ATOM 12731 CD1 LEU B 301 −34.715 −13.233 −33.437 1.00 24.42 C ATOM 12735 CD2 LEU B 301 −32.900 −12.998 −35.080 1.00 26.50 C ATOM 12739 C LEU B 301 −33.995 −9.425 −32.485 1.00 25.54 C ATOM 12740 O LEU B 301 −33.843 −9.959 −31.394 1.00 25.35 O ATOM 12742 N ASP B 302 −33.417 −8.257 −32.782 1.00 25.68 N ATOM 12743 CA ASP B 302 −32.598 −7.550 −31.774 1.00 26.02 C ATOM 12745 CB ASP B 302 −31.800 −6.377 −32.378 1.00 26.37 C ATOM 12748 CG ASP B 302 −30.563 −6.833 −33.167 1.00 28.27 C ATOM 12749 OD1 ASP B 302 −29.508 −6.156 −33.048 1.00 29.05 O ATOM 12750 OD2 ASP B 302 −30.652 −7.852 −33.910 1.00 31.04 O ATOM 12751 C ASP B 302 −33.472 −7.037 −30.630 1.00 25.69 C ATOM 12752 O ASP B 302 −33.110 −7.142 −29.447 1.00 25.90 O ATOM 12754 N GLU B 303 −34.622 −6.473 −30.993 1.00 25.04 N ATOM 12755 CA GLU B 303 −35.600 −6.029 −30.011 1.00 24.33 C ATOM 12757 CB GLU B 303 −36.783 −5.346 −30.697 1.00 24.20 C ATOM 12760 CG GLU B 303 −36.399 −4.109 −31.466 1.00 24.23 C ATOM 12763 CD GLU B 303 −37.589 −3.382 −32.063 1.00 24.23 C ATOM 12764 OE1 GLU B 303 −38.496 −4.065 −32.604 1.00 22.66 O ATOM 12765 OE2 GLU B 303 −37.592 −2.121 −31.995 1.00 23.93 O ATOM 12766 C GLU B 303 −36.103 −7.212 −29.193 1.00 23.87 C ATOM 12767 O GLU B 303 −36.396 −7.058 −28.011 1.00 23.59 O ATOM 12769 N LEU B 304 −36.204 −8.383 −29.825 1.00 23.39 N ATOM 12770 CA LEU B 304 −36.766 −9.570 −29.166 1.00 23.23 C ATOM 12772 CB LEU B 304 −37.180 −10.624 −30.208 1.00 22.83 C ATOM 12775 CG LEU B 304 −38.381 −10.217 −31.074 1.00 22.06 C ATOM 12777 CD1 LEU B 304 −38.822 −11.321 −32.037 1.00 20.11 C ATOM 12781 CD2 LEU B 304 −39.551 −9.800 −30.163 1.00 21.94 C ATOM 12785 C LEU B 304 −35.810 −10.147 −28.106 1.00 23.37 C ATOM 12786 O LEU B 304 −36.248 −10.785 −27.141 1.00 23.22 O ATOM 12788 N GLU B 305 −34.514 −9.892 −28.283 1.00 23.30 N ATOM 12789 CA GLU B 305 −33.512 −10.308 −27.324 1.00 23.18 C ATOM 12791 CB GLU B 305 −32.114 −10.176 −27.899 1.00 23.58 C ATOM 12794 CG GLU B 305 −31.832 −11.142 −29.047 1.00 25.27 C ATOM 12797 CD GLU B 305 −31.306 −12.488 −28.585 1.00 27.91 C ATOM 12798 OE1 GLU B 305 −30.946 −13.303 −29.470 1.00 29.87 O ATOM 12799 OE2 GLU B 305 −31.244 −12.728 −27.351 1.00 29.28 O ATOM 12800 C GLU B 305 −33.633 −9.440 −26.104 1.00 22.52 C ATOM 12801 O GLU B 305 −33.793 −9.956 −25.005 1.00 23.39 O ATOM 12803 N LEU B 306 −33.576 −8.124 −26.274 1.00 21.51 N ATOM 12804 CA LEU B 306 −33.715 −7.224 −25.114 1.00 20.70 C ATOM 12806 CB LEU B 306 −33.899 −5.764 −25.544 1.00 20.59 C ATOM 12809 CG LEU B 306 −32.769 −5.065 −26.293 1.00 20.12 C ATOM 12811 CD1 LEU B 306 −32.992 −3.576 −26.203 1.00 19.89 C ATOM 12815 CD2 LEU B 306 −31.402 −5.437 −25.739 1.00 19.81 C ATOM 12819 C LEU B 306 −34.896 −7.645 −24.237 1.00 19.91 C ATOM 12820 O LEU B 306 −34.771 −7.778 −23.031 1.00 19.53 O ATOM 12822 N PHE B 307 −36.030 −7.883 −24.872 1.00 19.48 N ATOM 12823 CA PHE B 307 −37.231 −8.267 −24.170 1.00 19.36 C ATOM 12825 CB PHE B 307 −38.400 −8.406 −25.138 1.00 19.54 C ATOM 12828 CG PHE B 307 −39.729 −8.296 −24.482 1.00 19.66 C ATOM 12829 CD1 PHE B 307 −40.365 −7.079 −24.400 1.00 21.03 C ATOM 12831 CE1 PHE B 307 −41.590 −6.968 −23.787 1.00 21.62 C ATOM 12833 CZ PHE B 307 −42.182 −8.072 −23.248 1.00 20.25 C ATOM 12835 CE2 PHE B 307 −41.553 −9.292 −23.329 1.00 20.07 C ATOM 12837 CD2 PHE B 307 −40.338 −9.400 −23.939 1.00 19.62 C ATOM 12839 C PHE B 307 −37.039 −9.577 −23.443 1.00 19.22 C ATOM 12840 O PHE B 307 −37.354 −9.684 −22.260 1.00 19.50 O ATOM 12842 N THR B 308 −36.532 −10.583 −24.143 1.00 18.96 N ATOM 12843 CA THR B 308 −36.321 −11.874 −23.511 1.00 18.84 C ATOM 12845 CB THR B 308 −35.774 −12.879 −24.490 1.00 18.62 C ATOM 12847 OG1 THR B 308 −36.687 −12.988 −25.579 1.00 18.88 O ATOM 12849 CG2 THR B 308 −35.626 −14.228 −23.833 1.00 18.74 C ATOM 12853 C THR B 308 −35.384 −11.737 −22.317 1.00 19.04 C ATOM 12854 O THR B 308 −35.686 −12.244 −21.233 1.00 18.69 O ATOM 12856 N ASP B 309 −34.264 −11.031 −22.511 1.00 19.36 N ATOM 12857 CA ASP B 309 −33.335 −10.751 −21.421 1.00 19.65 C ATOM 12859 CB ASP B 309 −32.121 −9.983 −21.942 1.00 19.92 C ATOM 12862 CG ASP B 309 −31.171 −9.536 −20.814 1.00 23.51 C ATOM 12863 OD1 ASP B 309 −30.520 −10.412 −20.175 1.00 27.27 O ATOM 12864 OD2 ASP B 309 −31.076 −8.299 −20.561 1.00 27.40 O ATOM 12865 C ASP B 309 −34.048 −9.977 −20.295 1.00 19.08 C ATOM 12866 O ASP B 309 −33.912 −10.308 −19.124 1.00 18.55 O ATOM 12868 N ALA B 310 −34.836 −8.975 −20.665 1.00 18.93 N ATOM 12869 CA ALA B 310 −35.546 −8.151 −19.688 1.00 19.12 C ATOM 12871 CB ALA B 310 −36.346 −7.062 −20.380 1.00 18.79 C ATOM 12875 C ALA B 310 −36.462 −8.965 −18.784 1.00 19.36 C ATOM 12876 O ALA B 310 −36.560 −8.696 −17.577 1.00 19.58 O ATOM 12878 N VAL B 311 −37.143 −9.942 −19.370 1.00 19.61 N ATOM 12879 CA VAL B 311 −37.996 −10.845 −18.611 1.00 19.68 C ATOM 12881 CB VAL B 311 −38.867 −11.682 −19.555 1.00 19.46 C ATOM 12883 CG1 VAL B 311 −39.948 −10.825 −20.123 1.00 18.49 C ATOM 12887 CG2 VAL B 311 −39.469 −12.863 −18.843 1.00 19.31 C ATOM 12891 C VAL B 311 −37.161 −11.726 −17.673 1.00 20.46 C ATOM 12892 O VAL B 311 −37.479 −11.843 −16.494 1.00 20.25 O ATOM 12894 N GLU B 312 −36.085 −12.317 −18.189 1.00 21.67 N ATOM 12895 CA GLU B 312 −35.198 −13.168 −17.384 1.00 22.65 C ATOM 12897 CB GLU B 312 −34.056 −13.708 −18.239 1.00 23.03 C ATOM 12900 CG GLU B 312 −34.454 −14.764 −19.261 1.00 24.88 C ATOM 12903 CD GLU B 312 −33.335 −15.077 −20.267 1.00 27.34 C ATOM 12904 OE1 GLU B 312 −33.485 −16.057 −21.028 1.00 29.07 O ATOM 12905 OE2 GLU B 312 −32.316 −14.342 −20.313 1.00 28.63 O ATOM 12906 C GLU B 312 −34.598 −12.443 −16.167 1.00 23.09 C ATOM 12907 O GLU B 312 −34.506 −13.007 −15.082 1.00 23.04 O ATOM 12909 N ARG B 313 −34.186 −11.199 −16.335 1.00 23.67 N ATOM 12910 CA ARG B 313 −33.590 −10.486 −15.222 1.00 24.60 C ATOM 12912 CB ARG B 313 −32.609 −9.436 −15.735 1.00 25.26 C ATOM 12915 CG ARG B 313 −31.333 −10.030 −16.398 1.00 27.83 C ATOM 12918 CD ARG B 313 −30.289 −8.943 −16.754 1.00 31.87 C ATOM 12921 NE ARG B 313 −30.922 −7.793 −17.430 1.00 35.71 N ATOM 12923 CZ ARG B 313 −31.341 −6.661 −16.837 1.00 38.42 C ATOM 12924 NH1 ARG B 313 −31.189 −6.452 −15.522 1.00 39.15 N ATOM 12927 NH2 ARG B 313 −31.919 −5.711 −17.576 1.00 39.25 N ATOM 12930 C ARG B 313 −34.638 −9.879 −14.280 1.00 24.67 C ATOM 12931 O ARG B 313 −34.359 −9.645 −13.117 1.00 24.09 O ATOM 12933 N TRP B 314 −35.843 −9.635 −14.781 1.00 25.60 N ATOM 12934 CA TRP B 314 −36.971 −9.180 −13.951 1.00 26.20 C ATOM 12936 CB TRP B 314 −37.488 −10.339 −13.097 1.00 25.90 C ATOM 12939 CG TRP B 314 −38.912 −10.184 −12.662 1.00 23.93 C ATOM 12940 CD1 TRP B 314 −39.355 −9.854 −11.424 1.00 22.76 C ATOM 12942 NE1 TRP B 314 −40.727 −9.804 −11.412 1.00 21.93 N ATOM 12944 CE2 TRP B 314 −41.189 −10.107 −12.659 1.00 20.38 C ATOM 12945 CD2 TRP B 314 −40.074 −10.352 −13.473 1.00 21.17 C ATOM 12946 CE3 TRP B 314 −40.277 −10.684 −14.811 1.00 20.19 C ATOM 12948 CZ3 TRP B 314 −41.549 −10.766 −15.280 1.00 19.79 C ATOM 12950 CH2 TRP B 314 −42.640 −10.512 −14.445 1.00 21.00 C ATOM 12952 CZ2 TRP B 314 −42.474 −10.179 −13.130 1.00 20.60 C ATOM 12954 C TRP B 314 −36.620 −7.966 −13.076 1.00 27.57 C ATOM 12955 O TRP B 314 −36.890 −7.935 −11.870 1.00 27.56 O ATOM 12957 N ASP B 315 −36.039 −6.959 −13.718 1.00 29.12 N ATOM 12958 CA ASP B 315 −35.452 −5.822 −13.027 1.00 30.46 C ATOM 12960 CB ASP B 315 −33.935 −5.796 −13.315 1.00 30.84 C ATOM 12963 CG ASP B 315 −33.227 −4.551 −12.772 1.00 32.75 C ATOM 12964 OD1 ASP B 315 −33.747 −3.904 −11.830 1.00 35.67 O ATOM 12965 OD2 ASP B 315 −32.128 −4.222 −13.295 1.00 34.91 O ATOM 12966 C ASP B 315 −36.157 −4.592 −13.557 1.00 31.10 C ATOM 12967 O ASP B 315 −35.888 −4.157 −14.674 1.00 31.35 O ATOM 12969 N VAL B 316 −37.088 −4.044 −12.781 1.00 32.06 N ATOM 12970 CA VAL B 316 −37.864 −2.896 −13.262 1.00 32.65 C ATOM 12972 CB VAL B 316 −39.016 −2.510 −12.334 1.00 32.45 C ATOM 12974 CG1 VAL B 316 −39.911 −1.499 −13.012 1.00 32.15 C ATOM 12978 CG2 VAL B 316 −38.490 −1.960 −11.040 1.00 32.91 C ATOM 12982 C VAL B 316 −36.964 −1.692 −13.442 1.00 33.43 C ATOM 12983 O VAL B 316 −37.228 −.854 −14.294 1.00 33.74 O ATOM 12985 N ASN B 317 −35.881 −1.628 −12.663 1.00 34.29 N ATOM 12986 CA ASN B 317 −34.937 −.510 −12.730 1.00 34.63 C ATOM 12988 CB ASN B 317 −33.995 −.526 −11.505 1.00 34.50 C ATOM 12991 CG ASN B 317 −34.692 −.084 −10.201 1.00 34.08 C ATOM 12992 OD1 ASN B 317 −35.198 1.042 −10.104 1.00 33.72 O ATOM 12993 ND2 ASN B 317 −34.690 −.961 −9.193 1.00 31.22 N ATOM 12996 C ASN B 317 −34.124 −.481 −14.029 1.00 35.21 C ATOM 12997 O ASN B 317 −33.196 .296 −14.127 1.00 35.52 O ATOM 12999 N ALA B 318 −34.470 −1.318 −15.013 1.00 35.89 N ATOM 13000 CA ALA B 318 −33.757 −1.382 −16.299 1.00 36.48 C ATOM 13002 CB ALA B 318 −32.727 −2.508 −16.253 1.00 36.49 C ATOM 13006 C ALA B 318 −34.695 −1.525 −17.534 1.00 37.02 C ATOM 13007 O ALA B 318 −34.297 −1.984 −18.616 1.00 36.52 O ATOM 13009 N ILE B 319 −35.952 −1.137 −17.339 1.00 37.76 N ATOM 13010 CA ILE B 319 −36.848 −.733 −18.424 1.00 38.08 C ATOM 13012 CB ILE B 319 −37.926 .247 −17.893 1.00 38.11 C ATOM 13014 CG1 ILE B 319 −39.110 −.495 −17.293 1.00 38.08 C ATOM 13017 CD1 ILE B 319 −40.068 .451 −16.596 1.00 38.27 C ATOM 13021 CG2 ILE B 319 −38.408 1.189 −18.996 1.00 37.84 C ATOM 13025 C ILE B 319 −36.134 .053 −19.516 1.00 38.29 C ATOM 13026 O ILE B 319 −36.192 −.324 −20.677 1.00 38.68 O ATOM 13028 N ASN B 320 −35.460 1.141 −19.125 1.00 38.36 N ATOM 13029 CA ASN B 320 −34.977 2.168 −20.074 1.00 38.17 C ATOM 13031 CB ASN B 320 −34.278 3.331 −19.331 1.00 38.16 C ATOM 13034 CG ASN B 320 −35.258 4.207 −18.514 1.00 37.87 C ATOM 13035 OD1 ASN B 320 −36.366 4.542 −18.955 1.00 36.50 O ATOM 13036 ND2 ASN B 320 −34.827 4.589 −17.322 1.00 38.12 N ATOM 13039 C ASN B 320 −34.082 1.643 −21.206 1.00 37.78 C ATOM 13040 O ASN B 320 −33.856 2.332 −22.181 1.00 37.76 O ATOM 13042 N ASP B 321 −33.600 .416 −21.083 1.00 37.46 N ATOM 13043 CA ASP B 321 −32.852 −.224 −22.162 1.00 37.25 C ATOM 13045 CB ASP B 321 −32.091 −1.467 −21.629 1.00 37.83 C ATOM 13048 CG ASP B 321 −31.351 −1.207 −20.285 1.00 39.33 C ATOM 13049 OD1 ASP B 321 −31.247 −.021 −19.871 1.00 40.72 O ATOM 13050 OD2 ASP B 321 −30.887 −2.199 −19.648 1.00 39.62 O ATOM 13051 C ASP B 321 −33.764 −.636 −23.339 1.00 35.99 C ATOM 13052 O ASP B 321 −33.273 −.904 −24.436 1.00 35.87 O ATOM 13054 N LEU B 322 −35.076 −.674 −23.111 1.00 34.66 N ATOM 13055 CA LEU B 322 −36.024 −1.263 −24.061 1.00 33.77 C ATOM 13057 CB LEU B 322 −37.180 −1.961 −23.327 1.00 33.65 C ATOM 13060 CG LEU B 322 −36.994 −3.260 −22.544 1.00 32.41 C ATOM 13062 CD1 LEU B 322 −38.223 −3.482 −21.693 1.00 31.54 C ATOM 13066 CD2 LEU B 322 −36.769 −4.432 −23.460 1.00 30.73 C ATOM 13070 C LEU B 322 −36.670 −.243 −24.982 1.00 33.32 C ATOM 13071 O LEU B 322 −36.910 .893 −24.570 1.00 33.37 O ATOM 13073 N PRO B 323 −37.005 −.667 −26.218 1.00 32.72 N ATOM 13074 CA PRO B 323 −37.856 .068 −27.126 1.00 32.42 C ATOM 13076 CB PRO B 323 −38.239 −.985 −28.158 1.00 32.28 C ATOM 13079 CG PRO B 323 −37.098 −1.849 −28.231 1.00 32.46 C ATOM 13082 CD PRO B 323 −36.498 −1.891 −26.857 1.00 32.79 C ATOM 13085 C PRO B 323 −39.115 .576 −26.453 1.00 32.50 C ATOM 13086 O PRO B 323 −39.655 −.083 −25.550 1.00 32.46 O ATOM 13087 N ASP B 324 −39.590 1.725 −26.923 1.00 32.44 N ATOM 13088 CA ASP B 324 −40.729 2.387 −26.318 1.00 32.44 C ATOM 13090 CB ASP B 324 −41.059 3.678 −27.071 1.00 32.91 C ATOM 13093 CG ASP B 324 −40.241 4.873 −26.576 1.00 34.17 C ATOM 13094 OD1 ASP B 324 −39.507 4.728 −25.562 1.00 35.83 O ATOM 13095 OD2 ASP B 324 −40.351 5.960 −27.196 1.00 35.42 O ATOM 13096 C ASP B 324 −41.967 1.504 −26.186 1.00 31.78 C ATOM 13097 O ASP B 324 −42.546 1.440 −25.102 1.00 31.77 O ATOM 13099 N TYR B 325 −42.368 .821 −27.258 1.00 30.99 N ATOM 13100 CA TYR B 325 −43.519 −.086 −27.167 1.00 30.49 C ATOM 13102 CB TYR B 325 −43.941 −.640 −28.536 1.00 30.28 C ATOM 13105 CG TYR B 325 −43.027 −1.688 −29.134 1.00 30.25 C ATOM 13106 CD1 TYR B 325 −41.917 −1.332 −29.893 1.00 29.81 C ATOM 13108 CE1 TYR B 325 −41.089 −2.300 −30.449 1.00 29.74 C ATOM 13110 CZ TYR B 325 −41.371 −3.643 −30.258 1.00 30.22 C ATOM 13111 OH TYR B 325 −40.565 −4.625 −30.805 1.00 31.28 O ATOM 13113 CE2 TYR B 325 −42.466 −4.015 −29.519 1.00 30.23 C ATOM 13115 CD2 TYR B 325 −43.288 −3.038 −28.963 1.00 30.49 C ATOM 13117 C TYR B 325 −43.284 −1.221 −26.168 1.00 30.14 C ATOM 13118 O TYR B 325 −44.219 −1.638 −25.483 1.00 30.19 O ATOM 13120 N MET B 326 −42.048 −1.700 −26.060 1.00 29.74 N ATOM 13121 CA MET B 326 −41.755 −2.820 −25.155 1.00 29.82 C ATOM 13123 CB MET B 326 −40.461 −3.541 −25.549 1.00 29.69 C ATOM 13126 CG MET B 326 −40.650 −4.510 −26.686 1.00 28.83 C ATOM 13129 SD MET B 326 −39.123 −5.272 −27.204 1.00 26.99 S ATOM 13130 CE MET B 326 −39.761 −6.499 −28.328 1.00 29.13 C ATOM 13134 C MET B 326 −41.696 −2.402 −23.683 1.00 29.92 C ATOM 13135 O MET B 326 −42.032 −3.204 −22.801 1.00 29.75 O ATOM 13137 N LYS B 327 −41.251 −1.166 −23.429 1.00 29.68 N ATOM 13138 CA LYS B 327 −41.318 −.578 −22.088 1.00 29.46 C ATOM 13140 CB LYS B 327 −41.016 .921 −22.114 1.00 29.93 C ATOM 13143 CG LYS B 327 −39.572 1.305 −21.951 1.00 31.63 C ATOM 13146 CD LYS B 327 −39.410 2.803 −22.249 1.00 34.93 C ATOM 13149 CE LYS B 327 −37.986 3.291 −22.021 1.00 36.86 C ATOM 13152 NZ LYS B 327 −37.642 4.436 −22.917 1.00 37.83 N ATOM 13156 C LYS B 327 −42.708 −.752 −21.531 1.00 28.46 C ATOM 13157 O LYS B 327 −42.879 −1.314 −20.461 1.00 28.54 O ATOM 13159 N LEU B 328 −43.696 −.258 −22.268 1.00 27.39 N ATOM 13160 CA LEU B 328 −45.056 −.216 −21.785 1.00 26.79 C ATOM 13162 CB LEU B 328 −45.946 .519 −22.773 1.00 26.68 C ATOM 13165 CG LEU B 328 −47.265 1.034 −22.212 1.00 26.00 C ATOM 13167 CD1 LEU B 328 −47.010 1.964 −21.036 1.00 24.88 C ATOM 13171 CD2 LEU B 328 −48.051 1.740 −23.308 1.00 24.55 C ATOM 13175 C LEU B 328 −45.560 −1.628 −21.587 1.00 26.70 C ATOM 13176 O LEU B 328 −46.110 −1.983 −20.543 1.00 27.03 O ATOM 13178 N CYS B 329 −45.341 −2.453 −22.591 1.00 26.39 N ATOM 13179 CA CYS B 329 −45.750 −3.843 −22.524 1.00 26.12 C ATOM 13181 CB CYS B 329 −45.382 −4.526 −23.838 1.00 26.47 C ATOM 13184 SG CYS B 329 −45.857 −6.236 −23.880 1.00 30.60 S ATOM 13186 C CYS B 329 −45.124 −4.568 −21.319 1.00 24.45 C ATOM 13187 O CYS B 329 −45.829 −5.105 −20.486 1.00 23.93 O ATOM 13189 N PHE B 330 −43.801 −4.553 −21.228 1.00 23.30 N ATOM 13190 CA PHE B 330 −43.087 −5.220 −20.141 1.00 22.47 C ATOM 13192 CB PHE B 330 −41.575 −5.019 −20.267 1.00 22.42 C ATOM 13195 CG PHE B 330 −40.800 −5.518 −19.076 1.00 22.37 C ATOM 13196 CD1 PHE B 330 −40.502 −6.864 −18.940 1.00 22.47 C ATOM 13198 CE1 PHE B 330 −39.799 −7.339 −17.836 1.00 21.64 C ATOM 13200 CZ PHE B 330 −39.379 −6.472 −16.866 1.00 21.50 C ATOM 13202 CE2 PHE B 330 −39.659 −5.122 −16.983 1.00 21.92 C ATOM 13204 CD2 PHE B 330 −40.374 −4.648 −18.084 1.00 22.29 C ATOM 13206 C PHE B 330 −43.524 −4.739 −18.765 1.00 21.87 C ATOM 13207 O PHE B 330 −43.779 −5.552 −17.875 1.00 21.98 O ATOM 13209 N LEU B 331 −43.594 −3.427 −18.573 1.00 20.88 N ATOM 13210 CA LEU B 331 −43.997 −2.894 −17.276 1.00 20.25 C ATOM 13212 CB LEU B 331 −43.927 −1.354 −17.257 1.00 20.06 C ATOM 13215 CG LEU B 331 −44.124 −.628 −15.912 1.00 19.21 C ATOM 13217 CD1 LEU B 331 −43.542 −1.408 −14.737 1.00 18.78 C ATOM 13221 CD2 LEU B 331 −43.555 .770 −15.957 1.00 15.75 C ATOM 13225 C LEU B 331 −45.398 −3.408 −16.902 1.00 19.99 C ATOM 13226 O LEU B 331 −45.606 −3.860 −15.771 1.00 19.67 O ATOM 13228 N ALA B 332 −46.336 −3.373 −17.860 1.00 19.56 N ATOM 13229 CA ALA B 332 −47.695 −3.882 −17.629 1.00 19.24 C ATOM 13231 CB ALA B 332 −48.528 −3.802 −18.891 1.00 18.58 C ATOM 13235 C ALA B 332 −47.637 −5.321 −17.108 1.00 19.23 C ATOM 13236 O ALA B 332 −48.235 −5.650 −16.079 1.00 19.18 O ATOM 13238 N LEU B 333 −46.891 −6.162 −17.816 1.00 19.16 N ATOM 13239 CA LEU B 333 −46.727 −7.554 −17.438 1.00 19.08 C ATOM 13241 CB LEU B 333 −45.830 −8.260 −18.462 1.00 18.97 C ATOM 13244 CG LEU B 333 −45.511 −9.758 −18.307 1.00 19.18 C ATOM 13246 CD1 LEU B 333 −46.779 −10.611 −18.121 1.00 18.09 C ATOM 13250 CD2 LEU B 333 −44.676 −10.262 −19.499 1.00 17.17 C ATOM 13254 C LEU B 333 −46.111 −7.616 −16.042 1.00 19.16 C ATOM 13255 O LEU B 333 −46.629 −8.279 −15.137 1.00 18.97 O ATOM 13257 N TYR B 334 −45.013 −6.887 −15.884 1.00 19.23 N ATOM 13258 CA TYR B 334 −44.212 −6.906 −14.664 1.00 19.33 C ATOM 13260 CB TYR B 334 −43.092 −5.873 −14.785 1.00 19.43 C ATOM 13263 CG TYR B 334 −42.190 −5.748 −13.596 1.00 19.44 C ATOM 13264 CD1 TYR B 334 −41.006 −6.464 −13.524 1.00 20.60 C ATOM 13266 CE1 TYR B 334 −40.148 −6.347 −12.442 1.00 20.77 C ATOM 13268 CZ TYR B 334 −40.474 −5.503 −11.417 1.00 21.51 C ATOM 13269 OH TYR B 334 −39.628 −5.387 −10.353 1.00 21.42 O ATOM 13271 CE2 TYR B 334 −41.646 −4.768 −11.466 1.00 22.15 C ATOM 13273 CD2 TYR B 334 −42.495 −4.892 −12.565 1.00 20.55 C ATOM 13275 C TYR B 334 −45.065 −6.614 −13.443 1.00 19.37 C ATOM 13276 O TYR B 334 −44.980 −7.337 −12.441 1.00 19.94 O ATOM 13278 N ASN B 335 −45.888 −5.565 −13.527 1.00 18.83 N ATOM 13279 CA ASN B 335 −46.784 −5.236 −12.443 1.00 18.37 C ATOM 13281 CB ASN B 335 −47.452 −3.896 −12.675 1.00 18.52 C ATOM 13284 CG ASN B 335 −46.493 −2.742 −12.518 1.00 19.27 C ATOM 13285 OD1 ASN B 335 −45.421 −2.906 −11.953 1.00 21.25 O ATOM 13286 ND2 ASN B 335 −46.872 −1.566 −13.022 1.00 19.24 N ATOM 13289 C ASN B 335 −47.812 −6.333 −12.291 1.00 18.22 C ATOM 13290 O ASN B 335 −47.966 −6.891 −11.207 1.00 18.53 O ATOM 13292 N THR B 336 −48.481 −6.697 −13.379 1.00 17.95 N ATOM 13293 CA THR B 336 −49.525 −7.728 −13.301 1.00 17.61 C ATOM 13295 CB THR B 336 −49.980 −8.204 −14.676 1.00 17.36 C ATOM 13297 OG1 THR B 336 −50.249 −7.065 −15.500 1.00 17.02 O ATOM 13299 CG2 THR B 336 −51.228 −9.044 −14.551 1.00 16.07 C ATOM 13303 C THR B 336 −49.065 −8.941 −12.501 1.00 17.75 C ATOM 13304 O THR B 336 −49.788 −9.429 −11.621 1.00 18.09 O ATOM 13306 N ILE B 337 −47.859 −9.411 −12.785 1.00 17.69 N ATOM 13307 CA ILE B 337 −47.384 −10.630 −12.165 1.00 17.74 C ATOM 13309 CB ILE B 337 −46.228 −11.245 −12.949 1.00 17.40 C ATOM 13311 CG1 ILE B 337 −46.795 −11.865 −14.227 1.00 18.44 C ATOM 13314 CD1 ILE B 337 −45.767 −12.192 −15.300 1.00 19.26 C ATOM 13318 CG2 ILE B 337 −45.568 −12.320 −12.152 1.00 16.25 C ATOM 13322 C ILE B 337 −47.053 −10.395 −10.699 1.00 18.32 C ATOM 13323 O ILE B 337 −47.497 −11.175 −9.838 1.00 18.06 O ATOM 13325 N ASN B 338 −46.321 −9.311 −10.404 1.00 18.89 N ATOM 13326 CA ASN B 338 −45.985 −8.978 −9.007 1.00 19.49 C ATOM 13328 CB ASN B 338 −45.189 −7.690 −8.917 1.00 19.43 C ATOM 13331 CG ASN B 338 −43.789 −7.836 −9.444 1.00 20.83 C ATOM 13332 OD1 ASN B 338 −43.292 −8.954 −9.634 1.00 21.52 O ATOM 13333 ND2 ASN B 338 −43.124 −6.697 −9.676 1.00 22.32 N ATOM 13336 C ASN B 338 −47.229 −8.835 −8.146 1.00 20.05 C ATOM 13337 O ASN B 338 −47.182 −9.055 −6.953 1.00 19.81 O ATOM 13339 N GLU B 339 −48.337 −8.459 −8.770 1.00 20.81 N ATOM 13340 CA GLU B 339 −49.589 −8.347 −8.086 1.00 21.81 C ATOM 13342 CB GLU B 339 −50.563 −7.544 −8.933 1.00 22.69 C ATOM 13345 CG GLU B 339 −51.240 −6.422 −8.148 1.00 27.28 C ATOM 13348 CD GLU B 339 −52.571 −5.959 −8.768 1.00 32.79 C ATOM 13349 OE1 GLU B 339 −52.761 −4.713 −8.897 1.00 36.20 O ATOM 13350 OE2 GLU B 339 −53.416 −6.837 −9.114 1.00 34.35 O ATOM 13351 C GLU B 339 −50.170 −9.732 −7.762 1.00 21.59 C ATOM 13352 O GLU B 339 −50.690 −9.946 −6.666 1.00 21.38 O ATOM 13354 N ILE B 340 −50.094 −10.676 −8.700 1.00 21.48 N ATOM 13355 CA ILE B 340 −50.486 −12.049 −8.384 1.00 21.27 C ATOM 13357 CB ILE B 340 −50.437 −12.990 −9.603 1.00 21.17 C ATOM 13359 CG1 ILE B 340 −51.478 −12.589 −10.643 1.00 20.99 C ATOM 13362 CD1 ILE B 340 −51.245 −13.202 −12.017 1.00 19.72 C ATOM 13366 CG2 ILE B 340 −50.702 −14.444 −9.177 1.00 21.09 C ATOM 13370 C ILE B 340 −49.557 −12.585 −7.278 1.00 21.40 C ATOM 13371 O ILE B 340 −50.023 −13.238 −6.334 1.00 21.74 O ATOM 13373 N ALA B 341 −48.256 −12.301 −7.380 1.00 20.90 N ATOM 13374 CA ALA B 341 −47.312 −12.721 −6.349 1.00 20.62 C ATOM 13376 CB ALA B 341 −45.922 −12.260 −6.694 1.00 20.53 C ATOM 13380 C ALA B 341 −47.720 −12.195 −4.969 1.00 20.59 C ATOM 13381 O ALA B 341 −47.606 −12.901 −3.950 1.00 20.57 O ATOM 13383 N TYR B 342 −48.208 −10.958 −4.949 1.00 20.62 N ATOM 13384 CA TYR B 342 −48.600 −10.303 −3.707 1.00 20.59 C ATOM 13386 CB TYR B 342 −48.790 −8.792 −3.907 1.00 20.05 C ATOM 13389 CG TYR B 342 −49.309 −8.143 −2.674 1.00 18.29 C ATOM 13390 CD1 TYR B 342 −48.443 −7.683 −1.698 1.00 17.62 C ATOM 13392 CE1 TYR B 342 −48.914 −7.111 −.518 1.00 17.91 C ATOM 13394 CZ TYR B 342 −50.285 −7.005 −.298 1.00 18.18 C ATOM 13395 OH TYR B 342 −50.763 −6.433 .877 1.00 16.00 O ATOM 13397 CE2 TYR B 342 −51.169 −7.467 −1.275 1.00 18.10 C ATOM 13399 CD2 TYR B 342 −50.670 −8.037 −2.450 1.00 17.67 C ATOM 13401 C TYR B 342 −49.863 −10.928 −3.118 1.00 21.48 C ATOM 13402 O TYR B 342 −49.960 −11.089 −1.913 1.00 20.91 O ATOM 13404 N ASP B 343 −50.832 −11.273 −3.959 1.00 22.93 N ATOM 13405 CA ASP B 343 −52.048 −11.925 −3.470 1.00 24.30 C ATOM 13407 CB ASP B 343 −53.010 −12.282 −4.608 1.00 24.59 C ATOM 13410 CG ASP B 343 −53.577 −11.060 −5.334 1.00 26.66 C ATOM 13411 OD1 ASP B 343 −53.619 −9.936 −4.756 1.00 28.24 O ATOM 13412 OD2 ASP B 343 −54.004 −11.247 −6.506 1.00 29.56 O ATOM 13413 C ASP B 343 −51.660 −13.208 −2.761 1.00 24.97 C ATOM 13414 O ASP B 343 −52.128 −13.495 −1.658 1.00 24.95 O ATOM 13416 N ASN B 344 −50.792 −13.973 −3.413 1.00 25.90 N ATOM 13417 CA ASN B 344 −50.322 −15.252 −2.884 1.00 26.59 C ATOM 13419 CB ASN B 344 −49.623 −16.043 −3.978 1.00 26.74 C ATOM 13422 CG ASN B 344 −50.594 −16.639 −4.933 1.00 28.21 C ATOM 13423 OD1 ASN B 344 −51.080 −17.737 −4.688 1.00 32.10 O ATOM 13424 ND2 ASN B 344 −50.923 −15.916 −6.016 1.00 28.40 N ATOM 13427 C ASN B 344 −49.421 −15.146 −1.655 1.00 26.78 C ATOM 13428 O ASN B 344 −49.424 −16.053 −.821 1.00 27.06 O ATOM 13430 N LEU B 345 −48.647 −14.067 −1.533 1.00 26.74 N ATOM 13431 CA LEU B 345 −47.970 −13.793 −.261 1.00 26.59 C ATOM 13433 CB LEU B 345 −47.005 −12.618 −.396 1.00 26.25 C ATOM 13436 CG LEU B 345 −46.046 −12.376 .764 1.00 24.65 C ATOM 13438 CD1 LEU B 345 −45.258 −13.621 1.115 1.00 22.50 C ATOM 13442 CD2 LEU B 345 −45.119 −11.251 .387 1.00 23.54 C ATOM 13446 C LEU B 345 −49.004 −13.503 .840 1.00 27.00 C ATOM 13447 O LEU B 345 −48.903 −14.014 1.947 1.00 26.93 O ATOM 13449 N LYS B 346 −50.008 −12.697 .518 1.00 27.54 N ATOM 13450 CA LYS B 346 −51.012 −12.300 1.491 1.00 27.96 C ATOM 13452 CB LYS B 346 −51.998 −11.288 .889 1.00 28.13 C ATOM 13455 CG LYS B 346 −52.822 −10.527 1.926 1.00 28.70 C ATOM 13458 CD LYS B 346 −53.781 −9.526 1.281 1.00 29.73 C ATOM 13461 CE LYS B 346 −55.205 −10.063 1.133 1.00 31.17 C ATOM 13464 NZ LYS B 346 −55.839 −9.661 −.171 1.00 32.83 N ATOM 13468 C LYS B 346 −51.788 −13.498 1.984 1.00 28.31 C ATOM 13469 O LYS B 346 −52.074 −13.600 3.177 1.00 28.52 O ATOM 13471 N ASP B 347 −52.149 −14.396 1.075 1.00 28.56 N ATOM 13472 CA ASP B 347 −53.102 −15.441 1.427 1.00 29.11 C ATOM 13474 CB ASP B 347 −54.068 −15.736 .268 1.00 29.50 C ATOM 13477 CG ASP B 347 −54.902 −14.500 −.150 1.00 31.04 C ATOM 13478 OD1 ASP B 347 −54.961 −13.500 .616 1.00 31.35 O ATOM 13479 OD2 ASP B 347 −55.496 −14.534 −1.261 1.00 33.39 O ATOM 13480 C ASP B 347 −52.403 −16.699 1.891 1.00 28.79 C ATOM 13481 O ASP B 347 −52.824 −17.321 2.854 1.00 29.02 O ATOM 13483 N LYS B 348 −51.326 −17.068 1.222 1.00 28.74 N ATOM 13484 CA LYS B 348 −50.612 −18.293 1.564 1.00 28.84 C ATOM 13486 CB LYS B 348 −50.290 −19.101 .299 1.00 29.24 C ATOM 13489 CG LYS B 348 −51.513 −19.470 −.576 1.00 30.97 C ATOM 13492 CD LYS B 348 −51.051 −20.300 −1.803 1.00 33.66 C ATOM 13495 CE LYS B 348 −52.033 −20.244 −2.989 1.00 34.52 C ATOM 13498 NZ LYS B 348 −53.445 −20.542 −2.607 1.00 35.61 N ATOM 13502 C LYS B 348 −49.330 −18.029 2.358 1.00 27.97 C ATOM 13503 O LYS B 348 −48.763 −18.948 2.925 1.00 27.88 O ATOM 13505 N GLY B 349 −48.874 −16.785 2.403 1.00 27.21 N ATOM 13506 CA GLY B 349 −47.625 −16.473 3.075 1.00 26.87 C ATOM 13509 C GLY B 349 −46.437 −17.227 2.514 1.00 26.71 C ATOM 13510 O GLY B 349 −45.576 −17.669 3.271 1.00 26.65 O ATOM 13512 N GLU B 350 −46.409 −17.390 1.191 1.00 26.61 N ATOM 13513 CA GLU B 350 −45.263 −17.953 .470 1.00 26.43 C ATOM 13515 CB GLU B 350 −45.624 −19.310 −.128 1.00 26.85 C ATOM 13518 CG GLU B 350 −45.685 −20.453 .888 1.00 29.63 C ATOM 13521 CD GLU B 350 −44.304 −21.036 1.227 1.00 34.21 C ATOM 13522 OE1 GLU B 350 −43.417 −21.045 .328 1.00 36.93 O ATOM 13523 OE2 GLU B 350 −44.106 −21.498 2.384 1.00 35.89 O ATOM 13524 C GLU B 350 −44.900 −16.981 −.637 1.00 25.49 C ATOM 13525 O GLU B 350 −45.774 −16.312 −1.181 1.00 25.35 O ATOM 13527 N ASN B 351 −43.616 −16.866 −.955 1.00 24.74 N ATOM 13528 CA ASN B 351 −43.206 −16.046 −2.090 1.00 24.47 C ATOM 13530 CB ASN B 351 −41.851 −15.369 −1.867 1.00 24.94 C ATOM 13533 CG ASN B 351 −41.428 −14.489 −3.062 1.00 26.98 C ATOM 13534 OD1 ASN B 351 −41.976 −14.605 −4.170 1.00 28.96 O ATOM 13535 ND2 ASN B 351 −40.457 −13.601 −2.834 1.00 29.55 N ATOM 13538 C ASN B 351 −43.095 −16.918 −3.303 1.00 23.33 C ATOM 13539 O ASN B 351 −42.120 −17.641 −3.429 1.00 23.47 O ATOM 13541 N ILE B 352 −44.060 −16.823 −4.208 1.00 22.09 N ATOM 13542 CA ILE B 352 −44.048 −17.644 −5.410 1.00 21.22 C ATOM 13544 CB ILE B 352 −45.452 −18.213 −5.675 1.00 21.23 C ATOM 13546 CG1 ILE B 352 −46.464 −17.080 −5.913 1.00 21.11 C ATOM 13549 CD1 ILE B 352 −47.346 −17.305 −7.126 1.00 20.33 C ATOM 13553 CG2 ILE B 352 −45.875 −19.116 −4.519 1.00 19.79 C ATOM 13557 C ILE B 352 −43.508 −16.947 −6.689 1.00 20.88 C ATOM 13558 O ILE B 352 −43.486 −17.553 −7.758 1.00 20.76 O ATOM 13560 N LEU B 353 −43.030 −15.705 −6.574 1.00 20.44 N ATOM 13561 CA LEU B 353 −42.603 −14.907 −7.750 1.00 19.84 C ATOM 13563 CB LEU B 353 −42.055 −13.527 −7.325 1.00 19.67 C ATOM 13566 CG LEU B 353 −42.003 −12.339 −8.311 1.00 18.47 C ATOM 13568 CD1 LEU B 353 −43.306 −12.083 −9.008 1.00 17.03 C ATOM 13572 CD2 LEU B 353 −41.604 −11.064 −7.597 1.00 17.08 C ATOM 13576 C LEU B 353 −41.587 −15.628 −8.633 1.00 19.81 C ATOM 13577 O LEU B 353 −41.720 −15.596 −9.851 1.00 19.55 O ATOM 13579 N PRO B 354 −40.578 −16.299 −8.024 1.00 20.01 N ATOM 13580 CA PRO B 354 −39.571 −17.010 −8.822 1.00 19.73 C ATOM 13582 CB PRO B 354 −38.781 −17.796 −7.779 1.00 19.55 C ATOM 13585 CG PRO B 354 −38.928 −17.037 −6.542 1.00 19.61 C ATOM 13588 CD PRO B 354 −40.289 −16.413 −6.578 1.00 19.90 C ATOM 13591 C PRO B 354 −40.187 −17.971 −9.804 1.00 19.87 C ATOM 13592 O PRO B 354 −39.693 −18.103 −10.918 1.00 20.08 O ATOM 13593 N TYR B 355 −41.264 −18.636 −9.387 1.00 20.14 N ATOM 13594 CA TYR B 355 −41.909 −19.665 −10.216 1.00 20.24 C ATOM 13596 CB TYR B 355 −42.878 −20.520 −9.394 1.00 20.40 C ATOM 13599 CG TYR B 355 −42.189 −21.153 −8.214 1.00 21.82 C ATOM 13600 CD1 TYR B 355 −41.119 −21.999 −8.412 1.00 22.86 C ATOM 13602 CE1 TYR B 355 −40.457 −22.564 −7.353 1.00 25.07 C ATOM 13604 CZ TYR B 355 −40.850 −22.285 −6.053 1.00 25.58 C ATOM 13605 OH TYR B 355 −40.153 −22.887 −5.020 1.00 27.33 O ATOM 13607 CE2 TYR B 355 −41.918 −21.433 −5.815 1.00 23.93 C ATOM 13609 CD2 TYR B 355 −42.577 −20.867 −6.900 1.00 23.10 C ATOM 13611 C TYR B 355 −42.625 −19.001 −11.361 1.00 19.67 C ATOM 13612 O TYR B 355 −42.455 −19.405 −12.510 1.00 19.75 O ATOM 13614 N LEU B 356 −43.385 −17.954 −11.030 1.00 18.97 N ATOM 13615 CA LEU B 356 −44.180 −17.205 −12.004 1.00 18.26 C ATOM 13617 CB LEU B 356 −45.039 −16.157 −11.293 1.00 18.03 C ATOM 13620 CG LEU B 356 −46.056 −16.727 −10.312 1.00 18.13 C ATOM 13622 CD1 LEU B 356 −46.691 −15.613 −9.500 1.00 19.37 C ATOM 13626 CD2 LEU B 356 −47.106 −17.521 −11.046 1.00 17.93 C ATOM 13630 C LEU B 356 −43.298 −16.536 −13.056 1.00 17.76 C ATOM 13631 O LEU B 356 −43.598 −16.567 −14.259 1.00 16.93 O ATOM 13633 N THR B 357 −42.201 −15.949 −12.600 1.00 17.56 N ATOM 13634 CA THR B 357 −41.335 −15.215 −13.501 1.00 17.63 C ATOM 13636 CB THR B 357 −40.438 −14.236 −12.759 1.00 17.69 C ATOM 13638 OG1 THR B 357 −39.530 −14.974 −11.934 1.00 18.39 O ATOM 13640 CG2 THR B 357 −41.288 −13.242 −11.927 1.00 16.47 C ATOM 13644 C THR B 357 −40.477 −16.145 −14.356 1.00 17.55 C ATOM 13645 O THR B 357 −40.154 −15.793 −15.498 1.00 17.17 O ATOM 13647 N LYS B 358 −40.127 −17.321 −13.824 1.00 17.37 N ATOM 13648 CA LYS B 358 −39.462 −18.337 −14.649 1.00 17.55 C ATOM 13650 CB LYS B 358 −39.030 −19.542 −13.827 1.00 17.87 C ATOM 13653 CG LYS B 358 −38.450 −20.718 −14.640 1.00 18.75 C ATOM 13656 CD LYS B 358 −37.013 −20.497 −15.112 1.00 20.18 C ATOM 13659 CE LYS B 358 −36.361 −21.843 −15.457 1.00 21.49 C ATOM 13662 NZ LYS B 358 −35.189 −21.702 −16.361 1.00 22.89 N ATOM 13666 C LYS B 358 −40.403 −18.777 −15.754 1.00 17.43 C ATOM 13667 O LYS B 358 −40.031 −18.775 −16.926 1.00 17.52 O ATOM 13669 N ALA B 359 −41.633 −19.120 −15.384 1.00 17.42 N ATOM 13670 CA ALA B 359 −42.654 −19.471 −16.359 1.00 17.52 C ATOM 13672 CB ALA B 359 −44.011 −19.434 −15.738 1.00 17.16 C ATOM 13676 C ALA B 359 −42.585 −18.521 −17.531 1.00 18.18 C ATOM 13677 O ALA B 359 −42.513 −18.956 −18.675 1.00 18.50 O ATOM 13679 N TRP B 360 −42.556 −17.223 −17.245 1.00 19.14 N ATOM 13680 CA TRP B 360 −42.526 −16.206 −18.301 1.00 19.77 C ATOM 13682 CB TRP B 360 −42.922 −14.837 −17.746 1.00 20.15 C ATOM 13685 CG TRP B 360 −44.377 −14.653 −17.813 1.00 20.50 C ATOM 13686 CD1 TRP B 360 −45.259 −14.729 −16.788 1.00 22.15 C ATOM 13688 NE1 TRP B 360 −46.536 −14.533 −17.248 1.00 22.84 N ATOM 13690 CE2 TRP B 360 −46.487 −14.348 −18.603 1.00 21.68 C ATOM 13691 CD2 TRP B 360 −45.134 −14.418 −18.987 1.00 20.85 C ATOM 13692 CE3 TRP B 360 −44.802 −14.253 −20.334 1.00 21.21 C ATOM 13694 CZ3 TRP B 360 −45.821 −14.025 −21.245 1.00 20.75 C ATOM 13696 CH2 TRP B 360 −47.166 −13.961 −20.827 1.00 21.21 C ATOM 13698 CZ2 TRP B 360 −47.515 −14.123 −19.516 1.00 20.97 C ATOM 13700 C TRP B 360 −41.215 −16.110 −19.081 1.00 19.96 C ATOM 13701 O TRP B 360 −41.242 −15.791 −20.271 1.00 19.94 O ATOM 13703 N ALA B 361 −40.089 −16.368 −18.420 1.00 20.14 N ATOM 13704 CA ALA B 361 −38.790 −16.437 −19.102 1.00 20.41 C ATOM 13706 CB ALA B 361 −37.676 −16.581 −18.102 1.00 20.67 C ATOM 13710 C ALA B 361 −38.763 −17.618 −20.041 1.00 20.55 C ATOM 13711 O ALA B 361 −38.330 −17.510 −21.187 1.00 20.76 O ATOM 13713 N ASP B 362 −39.230 −18.749 −19.534 1.00 20.57 N ATOM 13714 CA ASP B 362 −39.360 −19.965 −20.326 1.00 20.97 C ATOM 13716 CB ASP B 362 −39.984 −21.082 −19.470 1.00 21.39 C ATOM 13719 CG ASP B 362 −38.938 −21.902 −18.693 1.00 22.80 C ATOM 13720 OD1 ASP B 362 −38.836 −23.109 −18.970 1.00 28.57 O ATOM 13721 OD2 ASP B 362 −38.210 −21.384 −17.825 1.00 22.78 O ATOM 13722 C ASP B 362 −40.179 −19.748 −21.618 1.00 20.66 C ATOM 13723 O ASP B 362 −39.740 −20.141 −22.701 1.00 20.69 O ATOM 13725 N LEU B 363 −41.346 −19.110 −21.501 1.00 20.22 N ATOM 13726 CA LEU B 363 −42.245 −18.885 −22.648 1.00 19.82 C ATOM 13728 CB LEU B 363 −43.592 −18.327 −22.164 1.00 19.11 C ATOM 13731 CG LEU B 363 −44.644 −17.945 −23.209 1.00 17.02 C ATOM 13733 CD1 LEU B 363 −44.829 −19.033 −24.214 1.00 16.20 C ATOM 13737 CD2 LEU B 363 −45.979 −17.618 −22.586 1.00 14.21 C ATOM 13741 C LEU B 363 −41.633 −17.950 −23.706 1.00 20.76 C ATOM 13742 O LEU B 363 −41.656 −18.235 −24.910 1.00 21.00 O ATOM 13744 N CYS B 364 −41.088 −16.826 −23.253 1.00 21.42 N ATOM 13745 CA CYS B 364 −40.427 −15.884 −24.147 1.00 21.67 C ATOM 13747 CB CYS B 364 −39.969 −14.639 −23.376 1.00 21.86 C ATOM 13750 SG CYS B 364 −41.327 −13.638 −22.722 1.00 23.36 S ATOM 13752 C CYS B 364 −39.229 −16.547 −24.835 1.00 21.52 C ATOM 13753 O CYS B 364 −39.010 −16.323 −26.037 1.00 21.67 O ATOM 13755 N ASN B 365 −38.454 −17.352 −24.095 1.00 20.83 N ATOM 13756 CA ASN B 365 −37.306 −18.025 −24.713 1.00 20.65 C ATOM 13758 CB ASN B 365 −36.425 −18.756 −23.691 1.00 20.74 C ATOM 13761 CG ASN B 365 −35.330 −17.865 −23.100 1.00 20.53 C ATOM 13762 OD1 ASN B 365 −34.553 −17.229 −23.830 1.00 18.26 O ATOM 13763 ND2 ASN B 365 −35.252 −17.841 −21.763 1.00 20.69 N ATOM 13766 C ASN B 365 −37.756 −18.987 −25.811 1.00 20.43 C ATOM 13767 O ASN B 365 −36.998 −19.253 −26.759 1.00 20.11 O ATOM 13769 N ALA B 366 −38.987 −19.492 −25.667 1.00 20.01 N ATOM 13770 CA ALA B 366 −39.618 −20.340 −26.665 1.00 19.70 C ATOM 13772 CB ALA B 366 −40.766 −21.113 −26.045 1.00 19.53 C ATOM 13776 C ALA B 366 −40.099 −19.494 −27.838 1.00 19.74 C ATOM 13777 O ALA B 366 −39.846 −19.824 −28.989 1.00 19.61 O ATOM 13779 N PHE B 367 −40.791 −18.399 −27.553 1.00 19.99 N ATOM 13780 CA PHE B 367 −41.138 −17.446 −28.606 1.00 20.36 C ATOM 13782 CB PHE B 367 −41.805 −16.194 −28.026 1.00 20.62 C ATOM 13785 CG PHE B 367 −43.200 −16.403 −27.537 1.00 21.75 C ATOM 13786 CD1 PHE B 367 −44.136 −17.071 −28.315 1.00 23.00 C ATOM 13788 CE1 PHE B 367 −45.435 −17.242 −27.874 1.00 23.60 C ATOM 13790 CZ PHE B 367 −45.819 −16.731 −26.648 1.00 23.64 C ATOM 13792 CE2 PHE B 367 −44.901 −16.049 −25.871 1.00 23.56 C ATOM 13794 CD2 PHE B 367 −43.599 −15.883 −26.316 1.00 22.91 C ATOM 13796 C PHE B 367 −39.906 −16.986 −29.393 1.00 20.19 C ATOM 13797 O PHE B 367 −39.934 −16.903 −30.615 1.00 19.98 O ATOM 13799 N LEU B 368 −38.839 −16.659 −28.675 1.00 20.24 N ATOM 13800 CA LEU B 368 −37.629 −16.161 −29.298 1.00 20.31 C ATOM 13802 CB LEU B 368 −36.569 −15.900 −28.232 1.00 20.27 C ATOM 13805 CG LEU B 368 −35.235 −15.313 −28.694 1.00 20.12 C ATOM 13807 CD1 LEU B 368 −35.417 −14.069 −29.592 1.00 20.05 C ATOM 13811 CD2 LEU B 368 −34.409 −14.987 −27.465 1.00 18.60 C ATOM 13815 C LEU B 368 −37.122 −17.179 −30.295 1.00 20.53 C ATOM 13816 O LEU B 368 −36.844 −16.844 −31.446 1.00 20.49 O ATOM 13818 N GLN B 369 −37.032 −18.426 −29.832 1.00 20.80 N ATOM 13819 CA GLN B 369 −36.565 −19.557 −30.638 1.00 20.90 C ATOM 13821 CB GLN B 369 −36.614 −20.857 −29.815 1.00 20.98 C ATOM 13824 CG GLN B 369 −36.343 −22.159 −30.576 1.00 20.75 C ATOM 13827 CD GLN B 369 −34.946 −22.238 −31.126 1.00 20.29 C ATOM 13828 OE1 GLN B 369 −34.718 −21.984 −32.305 1.00 20.17 O ATOM 13829 NE2 GLN B 369 −33.996 −22.581 −30.272 1.00 20.33 N ATOM 13832 C GLN B 369 −37.365 −19.718 −31.910 1.00 21.04 C ATOM 13833 O GLN B 369 −36.803 −20.097 −32.929 1.00 20.82 O ATOM 13835 N GLU B 370 −38.668 −19.453 −31.863 1.00 21.80 N ATOM 13836 CA GLU B 370 −39.480 −19.512 −33.087 1.00 22.73 C ATOM 13838 CB GLU B 370 −40.996 −19.518 −32.801 1.00 23.18 C ATOM 13841 CG GLU B 370 −41.449 −20.608 −31.809 1.00 25.92 C ATOM 13844 CD GLU B 370 −42.927 −21.064 −31.957 1.00 29.74 C ATOM 13845 OE1 GLU B 370 −43.840 −20.191 −32.101 1.00 30.13 O ATOM 13846 OE2 GLU B 370 −43.156 −22.316 −31.892 1.00 31.94 O ATOM 13847 C GLU B 370 −39.079 −18.358 −34.016 1.00 22.62 C ATOM 13848 O GLU B 370 −38.933 −18.565 −35.221 1.00 22.53 O ATOM 13850 N ALA B 371 −38.864 −17.166 −33.456 1.00 22.65 N ATOM 13851 CA ALA B 371 −38.427 −16.023 −34.254 1.00 22.95 C ATOM 13853 CB ALA B 371 −38.375 −14.753 −33.424 1.00 22.97 C ATOM 13857 C ALA B 371 −37.070 −16.296 −34.891 1.00 23.13 C ATOM 13858 O ALA B 371 −36.900 −16.063 −36.091 1.00 23.38 O ATOM 13860 N LYS B 372 −36.113 −16.804 −34.107 1.00 23.15 N ATOM 13861 CA LYS B 372 −34.776 −17.102 −34.640 1.00 23.10 C ATOM 13863 CB LYS B 372 −33.808 −17.633 −33.575 1.00 22.85 C ATOM 13866 CG LYS B 372 −33.414 −16.616 −32.514 1.00 24.28 C ATOM 13869 CD LYS B 372 −31.973 −16.806 −31.969 1.00 26.34 C ATOM 13872 CE LYS B 372 −31.919 −17.407 −30.544 1.00 27.84 C ATOM 13875 NZ LYS B 372 −31.673 −16.405 −29.458 1.00 27.93 N ATOM 13879 C LYS B 372 −34.887 −18.093 −35.790 1.00 23.16 C ATOM 13880 O LYS B 372 −34.231 −17.920 −36.804 1.00 23.73 O ATOM 13882 N TRP B 373 −35.720 −19.122 −35.658 1.00 23.11 N ATOM 13883 CA TRP B 373 −35.844 −20.094 −36.742 1.00 22.99 C ATOM 13885 CB TRP B 373 −36.746 −21.274 −36.370 1.00 22.71 C ATOM 13888 CG TRP B 373 −36.081 −22.343 −35.562 1.00 20.71 C ATOM 13889 CD1 TRP B 373 −34.770 −22.740 −35.623 1.00 19.89 C ATOM 13891 NE1 TRP B 373 −34.540 −23.757 −34.734 1.00 19.05 N ATOM 13893 CE2 TRP B 373 −35.715 −24.050 −34.090 1.00 18.91 C ATOM 13894 CD2 TRP B 373 −36.707 −23.184 −34.599 1.00 18.41 C ATOM 13895 CE3 TRP B 373 −38.007 −23.288 −34.105 1.00 15.66 C ATOM 13897 CZ3 TRP B 373 −38.271 −24.216 −33.130 1.00 15.41 C ATOM 13899 CH2 TRP B 373 −37.276 −25.069 −32.647 1.00 16.33 C ATOM 13901 CZ2 TRP B 373 −35.994 −25.005 −33.112 1.00 17.53 C ATOM 13903 C TRP B 373 −36.374 −19.416 −37.991 1.00 23.59 C ATOM 13904 O TRP B 373 −35.878 −19.653 −39.096 1.00 23.60 O ATOM 13906 N LEU B 374 −37.374 −18.559 −37.801 1.00 24.32 N ATOM 13907 CA LEU B 374 −38.008 −17.859 −38.915 1.00 24.66 C ATOM 13909 CB LEU B 374 −39.181 −17.019 −38.428 1.00 24.85 C ATOM 13912 CG LEU B 374 −40.112 −16.449 −39.496 1.00 25.45 C ATOM 13914 CD1 LEU B 374 −41.002 −17.535 −40.070 1.00 24.83 C ATOM 13918 CD2 LEU B 374 −40.959 −15.293 −38.885 1.00 26.92 C ATOM 13922 C LEU B 374 −37.009 −16.975 −39.618 1.00 24.64 C ATOM 13923 O LEU B 374 −36.934 −16.992 −40.830 1.00 24.33 O ATOM 13925 N TYR B 375 −36.232 −16.220 −38.850 1.00 25.09 N ATOM 13926 CA TYR B 375 −35.283 −15.274 −39.433 1.00 25.71 C ATOM 13928 CB TYR B 375 −34.534 −14.479 −38.349 1.00 25.91 C ATOM 13931 CG TYR B 375 −33.536 −13.468 −38.892 1.00 27.11 C ATOM 13932 CD1 TYR B 375 −33.950 −12.200 −39.305 1.00 27.98 C ATOM 13934 CE1 TYR B 375 −33.039 −11.271 −39.811 1.00 28.61 C ATOM 13936 CZ TYR B 375 −31.693 −11.605 −39.904 1.00 29.13 C ATOM 13937 OH TYR B 375 −30.790 −10.685 −40.397 1.00 29.83 O ATOM 13939 CE2 TYR B 375 −31.256 −12.863 −39.501 1.00 28.79 C ATOM 13941 CD2 TYR B 375 −32.177 −13.783 −38.995 1.00 28.03 C ATOM 13943 C TYR B 375 −34.305 −16.036 −40.301 1.00 25.64 C ATOM 13944 O TYR B 375 −34.201 −15.788 −41.503 1.00 25.74 O ATOM 13946 N ASN B 376 −33.635 −17.000 −39.685 1.00 25.73 N ATOM 13947 CA ASN B 376 −32.599 −17.777 −40.346 1.00 25.78 C ATOM 13949 CB ASN B 376 −31.739 −18.497 −39.303 1.00 25.73 C ATOM 13952 CG ASN B 376 −31.155 −17.565 −38.273 1.00 25.13 C ATOM 13953 OD1 ASN B 376 −30.491 −16.590 −38.601 1.00 25.53 O ATOM 13954 ND2 ASN B 376 −31.389 −17.874 −37.013 1.00 24.64 N ATOM 13957 C ASN B 376 −33.126 −18.824 −41.332 1.00 26.04 C ATOM 13958 O ASN B 376 −32.343 −19.644 −41.807 1.00 26.36 O ATOM 13960 N LYS B 377 −34.428 −18.824 −41.632 1.00 26.16 N ATOM 13961 CA LYS B 377 −35.012 −19.811 −42.552 1.00 26.27 C ATOM 13963 CB LYS B 377 −34.575 −19.538 −44.010 1.00 26.51 C ATOM 13966 CG LYS B 377 −35.470 −18.561 −44.802 1.00 28.01 C ATOM 13969 CD LYS B 377 −34.629 −17.592 −45.667 1.00 29.99 C ATOM 13972 CE LYS B 377 −35.493 −16.605 −46.465 1.00 31.02 C ATOM 13975 NZ LYS B 377 −36.420 −15.819 −45.589 1.00 32.17 N ATOM 13979 C LYS B 377 −34.647 −21.243 −42.150 1.00 25.93 C ATOM 13980 O LYS B 377 −34.380 −22.084 −43.003 1.00 25.82 O ATOM 13982 N SER B 378 −34.637 −21.522 −40.852 1.00 25.65 N ATOM 13983 CA SER B 378 −34.324 −22.860 −40.385 1.00 25.54 C ATOM 13985 CB SER B 378 −34.132 −22.877 −38.882 1.00 25.41 C ATOM 13988 OG SER B 378 −32.905 −22.269 −38.570 1.00 25.67 O ATOM 13990 C SER B 378 −35.412 −23.838 −40.790 1.00 25.62 C ATOM 13991 O SER B 378 −36.495 −23.435 −41.199 1.00 25.70 O ATOM 13993 N THR B 379 −35.108 −25.129 −40.690 1.00 25.66 N ATOM 13994 CA THR B 379 −36.038 −26.175 −41.097 1.00 25.55 C ATOM 13996 CB THR B 379 −35.788 −26.635 −42.546 1.00 25.59 C ATOM 13998 OG1 THR B 379 −34.391 −26.899 −42.736 1.00 25.46 O ATOM 14000 CG2 THR B 379 −36.255 −25.574 −43.528 1.00 25.88 C ATOM 14004 C THR B 379 −35.886 −27.348 −40.160 1.00 25.45 C ATOM 14005 O THR B 379 −35.372 −28.393 −40.548 1.00 25.70 O ATOM 14007 N PRO B 380 −36.335 −27.179 −38.915 1.00 25.37 N ATOM 14008 CA PRO B 380 −36.144 −28.182 −37.876 1.00 25.22 C ATOM 14010 CB PRO B 380 −36.500 −27.437 −36.583 1.00 25.19 C ATOM 14013 CG PRO B 380 −36.643 −26.021 −36.955 1.00 25.83 C ATOM 14016 CD PRO B 380 −37.025 −25.998 −38.390 1.00 25.71 C ATOM 14019 C PRO B 380 −37.052 −29.379 −38.009 1.00 24.82 C ATOM 14020 O PRO B 380 −38.143 −29.280 −38.575 1.00 24.84 O ATOM 14021 N THR B 381 −36.607 −30.493 −37.436 1.00 24.42 N ATOM 14022 CA THR B 381 −37.386 −31.712 −37.429 1.00 23.99 C ATOM 14024 CB THR B 381 −36.614 −32.873 −36.789 1.00 23.99 C ATOM 14026 OG1 THR B 381 −36.339 −32.575 −35.418 1.00 24.02 O ATOM 14028 CG2 THR B 381 −35.302 −33.117 −37.524 1.00 23.76 C ATOM 14032 C THR B 381 −38.649 −31.461 −36.636 1.00 23.78 C ATOM 14033 O THR B 381 −38.700 −30.548 −35.813 1.00 23.89 O ATOM 14035 N PHE B 382 −39.672 −32.267 −36.889 1.00 23.53 N ATOM 14036 CA PHE B 382 −40.905 −32.204 −36.105 1.00 22.97 C ATOM 14038 CB PHE B 382 −41.870 −33.305 −36.527 1.00 22.89 C ATOM 14041 CG PHE B 382 −43.079 −33.394 −35.655 1.00 22.26 C ATOM 14042 CD1 PHE B 382 −44.189 −32.601 −35.910 1.00 21.65 C ATOM 14044 CE1 PHE B 382 −45.300 −32.672 −35.099 1.00 20.87 C ATOM 14046 CZ PHE B 382 −45.310 −33.534 −34.016 1.00 20.36 C ATOM 14048 CE2 PHE B 382 −44.204 −34.317 −33.744 1.00 20.52 C ATOM 14050 CD2 PHE B 382 −43.098 −34.243 −34.556 1.00 21.17 C ATOM 14052 C PHE B 382 −40.677 −32.329 −34.605 1.00 22.69 C ATOM 14053 O PHE B 382 −41.341 −31.657 −33.834 1.00 22.44 O ATOM 14055 N ASP B 383 −39.764 −33.205 −34.191 1.00 22.52 N ATOM 14056 CA ASP B 383 −39.491 −33.375 −32.765 1.00 22.50 C ATOM 14058 CB ASP B 383 −38.531 −34.525 −32.527 1.00 22.43 C ATOM 14061 CG ASP B 383 −39.174 −35.863 −32.711 1.00 22.71 C ATOM 14062 OD1 ASP B 383 −40.359 −35.945 −33.074 1.00 22.89 O ATOM 14063 OD2 ASP B 383 −38.470 −36.856 −32.492 1.00 25.17 O ATOM 14064 C ASP B 383 −38.954 −32.116 −32.091 1.00 22.43 C ATOM 14065 O ASP B 383 −39.438 −31.758 −31.014 1.00 22.40 O ATOM 14067 N ASP B 384 −37.966 −31.464 −32.713 1.00 22.37 N ATOM 14068 CA ASP B 384 −37.422 −30.191 −32.213 1.00 22.61 C ATOM 14070 CB ASP B 384 −36.317 −29.648 −33.124 1.00 22.82 C ATOM 14073 CG ASP B 384 −34.963 −30.208 −32.807 1.00 23.40 C ATOM 14074 OD1 ASP B 384 −34.847 −30.973 −31.832 1.00 25.33 O ATOM 14075 OD2 ASP B 384 −34.009 −29.891 −33.545 1.00 24.26 O ATOM 14076 C ASP B 384 −38.482 −29.113 −32.130 1.00 22.56 C ATOM 14077 O ASP B 384 −38.598 −28.429 −31.108 1.00 22.48 O ATOM 14079 N TYR B 385 −39.227 −28.963 −33.227 1.00 22.36 N ATOM 14080 CA TYR B 385 −40.170 −27.870 −33.402 1.00 22.18 C ATOM 14082 CB TYR B 385 −40.738 −27.867 −34.812 1.00 22.05 C ATOM 14085 CG TYR B 385 −41.818 −26.834 −35.019 1.00 22.60 C ATOM 14086 CD1 TYR B 385 −41.493 −25.553 −35.437 1.00 23.64 C ATOM 14088 CE1 TYR B 385 −42.462 −24.580 −35.630 1.00 25.00 C ATOM 14090 CZ TYR B 385 −43.788 −24.882 −35.410 1.00 26.86 C ATOM 14091 OH TYR B 385 −44.734 −23.883 −35.622 1.00 28.48 O ATOM 14093 CE2 TYR B 385 −44.149 −26.171 −34.980 1.00 25.95 C ATOM 14095 CD2 TYR B 385 −43.158 −27.133 −34.790 1.00 23.94 C ATOM 14097 C TYR B 385 −41.319 −27.986 −32.446 1.00 22.13 C ATOM 14098 O TYR B 385 −41.703 −27.017 −31.808 1.00 22.95 O ATOM 14100 N PHE B 386 −41.899 −29.169 −32.380 1.00 21.80 N ATOM 14101 CA PHE B 386 −43.048 −29.394 −31.525 1.00 21.62 C ATOM 14103 CB PHE B 386 −43.624 −30.795 −31.768 1.00 21.73 C ATOM 14106 CG PHE B 386 −44.834 −31.104 −30.952 1.00 21.27 C ATOM 14107 CD1 PHE B 386 −46.034 −30.447 −31.196 1.00 22.55 C ATOM 14109 CE1 PHE B 386 −47.164 −30.732 −30.448 1.00 23.14 C ATOM 14111 CZ PHE B 386 −47.095 −31.699 −29.446 1.00 23.20 C ATOM 14113 CE2 PHE B 386 −45.896 −32.358 −29.208 1.00 21.57 C ATOM 14115 CD2 PHE B 386 −44.781 −32.057 −29.959 1.00 20.29 C ATOM 14117 C PHE B 386 −42.630 −29.226 −30.073 1.00 21.34 C ATOM 14118 O PHE B 386 −43.353 −28.639 −29.284 1.00 21.44 O ATOM 14120 N GLY B 387 −41.447 −29.725 −29.736 1.00 20.84 N ATOM 14121 CA GLY B 387 −40.935 −29.618 −28.387 1.00 20.57 C ATOM 14124 C GLY B 387 −40.854 −28.186 −27.916 1.00 20.26 C ATOM 14125 O GLY B 387 −40.930 −27.908 −26.724 1.00 20.86 O ATOM 14127 N ASN B 388 −40.691 −27.268 −28.852 1.00 19.81 N ATOM 14128 CA ASN B 388 −40.758 −25.853 −28.536 1.00 19.51 C ATOM 14130 CB ASN B 388 −39.877 −25.086 −29.508 1.00 19.42 C ATOM 14133 CG ASN B 388 −39.593 −23.700 −29.045 1.00 19.26 C ATOM 14134 OD1 ASN B 388 −38.916 −23.513 −28.038 1.00 18.93 O ATOM 14135 ND2 ASN B 388 −40.105 −22.709 −29.774 1.00 17.99 N ATOM 14138 C ASN B 388 −42.200 −25.320 −28.604 1.00 19.41 C ATOM 14139 O ASN B 388 −42.591 −24.447 −27.833 1.00 19.58 O ATOM 14141 N ALA B 389 −42.989 −25.848 −29.532 1.00 19.11 N ATOM 14142 CA ALA B 389 −44.313 −25.307 −29.808 1.00 18.87 C ATOM 14144 CB ALA B 389 −44.897 −25.949 −31.060 1.00 18.87 C ATOM 14148 C ALA B 389 −45.264 −25.460 −28.634 1.00 18.51 C ATOM 14149 O ALA B 389 −45.916 −24.511 −28.262 1.00 18.33 O ATOM 14151 N TRP B 390 −45.344 −26.652 −28.054 1.00 18.73 N ATOM 14152 CA TRP B 390 −46.258 −26.887 −26.935 1.00 18.74 C ATOM 14154 CB TRP B 390 −46.389 −28.377 −26.569 1.00 18.75 C ATOM 14157 CG TRP B 390 −45.166 −29.122 −26.019 1.00 18.46 C ATOM 14158 CD1 TRP B 390 −44.390 −30.001 −26.705 1.00 18.75 C ATOM 14160 NE1 TRP B 390 −43.417 −30.519 −25.897 1.00 17.56 N ATOM 14162 CE2 TRP B 390 −43.559 −30.005 −24.642 1.00 16.67 C ATOM 14163 CD2 TRP B 390 −44.661 −29.124 −24.674 1.00 17.50 C ATOM 14164 CE3 TRP B 390 −45.008 −28.448 −23.505 1.00 18.38 C ATOM 14166 CZ3 TRP B 390 −44.251 −28.685 −22.347 1.00 18.34 C ATOM 14168 CH2 TRP B 390 −43.164 −29.573 −22.361 1.00 16.75 C ATOM 14170 CZ2 TRP B 390 −42.805 −30.234 −23.495 1.00 15.75 C ATOM 14172 C TRP B 390 −45.861 −26.066 −25.727 1.00 18.91 C ATOM 14173 O TRP B 390 −46.707 −25.691 −24.919 1.00 19.02 O ATOM 14175 N LYS B 391 −44.570 −25.787 −25.612 1.00 18.95 N ATOM 14176 CA LYS B 391 −44.085 −24.810 −24.643 1.00 18.85 C ATOM 14178 CB LYS B 391 −42.544 −24.888 −24.508 1.00 19.52 C ATOM 14181 CG LYS B 391 −42.023 −25.373 −23.143 1.00 21.17 C ATOM 14184 CD LYS B 391 −40.516 −25.689 −23.191 1.00 22.87 C ATOM 14187 CE LYS B 391 −40.251 −27.159 −23.508 1.00 23.91 C ATOM 14190 NZ LYS B 391 −38.938 −27.354 −24.191 1.00 25.44 N ATOM 14194 C LYS B 391 −44.537 −23.400 −25.032 1.00 17.57 C ATOM 14195 O LYS B 391 −44.937 −22.629 −24.180 1.00 17.66 O ATOM 14197 N SER B 392 −44.490 −23.068 −26.314 1.00 16.65 N ATOM 14198 CA SER B 392 −44.879 −21.718 −26.764 1.00 16.27 C ATOM 14200 CB SER B 392 −44.241 −21.375 −28.119 1.00 16.22 C ATOM 14203 OG SER B 392 −44.937 −21.969 −29.207 1.00 15.94 O ATOM 14205 C SER B 392 −46.384 −21.504 −26.866 1.00 15.87 C ATOM 14206 O SER B 392 −46.825 −20.395 −27.093 1.00 15.56 O ATOM 14208 N SER B 393 −47.167 −22.568 −26.724 1.00 15.92 N ATOM 14209 CA SER B 393 −48.629 −22.474 −26.718 1.00 15.80 C ATOM 14211 CB SER B 393 −49.240 −23.867 −26.630 1.00 15.78 C ATOM 14214 OG SER B 393 −49.025 −24.426 −25.348 1.00 15.00 O ATOM 14216 C SER B 393 −49.097 −21.646 −25.533 1.00 15.94 C ATOM 14217 O SER B 393 −50.115 −20.948 −25.599 1.00 15.60 O ATOM 14219 N SER B 394 −48.296 −21.740 −24.471 1.00 16.14 N ATOM 14220 CA SER B 394 −48.487 −21.091 −23.177 1.00 16.31 C ATOM 14222 CB SER B 394 −49.062 −19.662 −23.271 1.00 16.18 C ATOM 14225 OG SER B 394 −50.472 −19.649 −23.358 1.00 16.57 O ATOM 14227 C SER B 394 −49.316 −22.006 −22.297 1.00 16.34 C ATOM 14228 O SER B 394 −49.822 −21.595 −21.261 1.00 16.47 O ATOM 14230 N GLY B 395 −49.403 −23.268 −22.702 1.00 16.55 N ATOM 14231 CA GLY B 395 −50.103 −24.282 −21.927 1.00 16.79 C ATOM 14234 C GLY B 395 −49.543 −24.391 −20.534 1.00 16.80 C ATOM 14235 O GLY B 395 −50.222 −24.083 −19.556 1.00 16.74 O ATOM 14237 N PRO B 396 −48.291 −24.824 −20.430 1.00 17.07 N ATOM 14238 CA PRO B 396 −47.698 −24.930 −19.103 1.00 17.18 C ATOM 14240 CB PRO B 396 −46.273 −25.399 −19.386 1.00 17.09 C ATOM 14243 CG PRO B 396 −46.087 −25.237 −20.874 1.00 17.77 C ATOM 14246 CD PRO B 396 −47.424 −25.390 −21.470 1.00 17.20 C ATOM 14249 C PRO B 396 −47.707 −23.615 −18.313 1.00 17.17 C ATOM 14250 O PRO B 396 −47.921 −23.644 −17.089 1.00 17.10 O ATOM 14251 N LEU B 397 −47.499 −22.475 −18.983 1.00 17.04 N ATOM 14252 CA LEU B 397 −47.513 −21.183 −18.261 1.00 16.77 C ATOM 14254 CB LEU B 397 −47.116 −19.969 −19.135 1.00 16.84 C ATOM 14257 CG LEU B 397 −47.145 −18.576 −18.458 1.00 16.91 C ATOM 14259 CD1 LEU B 397 −46.577 −18.641 −17.096 1.00 18.36 C ATOM 14263 CD2 LEU B 397 −46.373 −17.515 −19.196 1.00 16.88 C ATOM 14267 C LEU B 397 −48.894 −20.988 −17.682 1.00 16.24 C ATOM 14268 O LEU B 397 −49.051 −20.710 −16.494 1.00 16.09 O ATOM 14270 N GLN B 398 −49.902 −21.173 −18.515 1.00 15.72 N ATOM 14271 CA GLN B 398 −51.262 −21.093 −18.024 1.00 15.49 C ATOM 14273 CB GLN B 398 −52.267 −21.387 −19.120 1.00 15.51 C ATOM 14276 CG GLN B 398 −52.371 −20.275 −20.118 1.00 16.12 C ATOM 14279 CD GLN B 398 −53.436 −20.545 −21.114 1.00 17.86 C ATOM 14280 OE1 GLN B 398 −54.509 −21.028 −20.757 1.00 20.99 O ATOM 14281 NE2 GLN B 398 −53.170 −20.239 −22.374 1.00 18.31 N ATOM 14284 C GLN B 398 −51.471 −22.040 −16.873 1.00 15.03 C ATOM 14285 O GLN B 398 −51.974 −21.638 −15.843 1.00 15.21 O ATOM 14287 N LEU B 399 −51.065 −23.291 −17.022 1.00 14.72 N ATOM 14288 CA LEU B 399 −51.361 −24.254 −15.978 1.00 14.65 C ATOM 14290 CB LEU B 399 −51.201 −25.688 −16.475 1.00 14.44 C ATOM 14293 CG LEU B 399 −52.250 −26.191 −17.478 1.00 14.28 C ATOM 14295 CD1 LEU B 399 −51.907 −27.633 −17.846 1.00 15.50 C ATOM 14299 CD2 LEU B 399 −53.713 −26.077 −16.986 1.00 10.96 C ATOM 14303 C LEU B 399 −50.554 −23.995 −14.704 1.00 14.88 C ATOM 14304 O LEU B 399 −51.100 −24.161 −13.618 1.00 15.21 O ATOM 14306 N ILE B 400 −49.291 −23.562 −14.810 1.00 14.91 N ATOM 14307 CA ILE B 400 −48.532 −23.174 −13.607 1.00 14.89 C ATOM 14309 CB ILE B 400 −47.158 −22.574 −13.907 1.00 15.19 C ATOM 14311 CG1 ILE B 400 −46.189 −23.674 −14.353 1.00 16.76 C ATOM 14314 CD1 ILE B 400 −44.777 −23.162 −14.716 1.00 18.19 C ATOM 14318 CG2 ILE B 400 −46.603 −21.906 −12.665 1.00 13.65 C ATOM 14322 C ILE B 400 −49.288 −22.137 −12.819 1.00 14.77 C ATOM 14323 O ILE B 400 −49.485 −22.302 −11.632 1.00 15.36 O ATOM 14325 N PHE B 401 −49.717 −21.071 −13.486 1.00 14.59 N ATOM 14326 CA PHE B 401 −50.491 −20.001 −12.844 1.00 14.22 C ATOM 14328 CB PHE B 401 −50.825 −18.900 −13.845 1.00 14.12 C ATOM 14331 CG PHE B 401 −49.803 −17.790 −13.872 1.00 13.83 C ATOM 14332 CD1 PHE B 401 −50.012 −16.623 −13.173 1.00 12.77 C ATOM 14334 CE1 PHE B 401 −49.074 −15.629 −13.189 1.00 13.09 C ATOM 14336 CZ PHE B 401 −47.906 −15.781 −13.902 1.00 12.96 C ATOM 14338 CE2 PHE B 401 −47.684 −16.928 −14.592 1.00 12.86 C ATOM 14340 CD2 PHE B 401 −48.622 −17.932 −14.574 1.00 13.30 C ATOM 14342 C PHE B 401 −51.765 −20.478 −12.212 1.00 14.26 C ATOM 14343 O PHE B 401 −52.184 −19.944 −11.207 1.00 13.90 O ATOM 14345 N ALA B 402 −52.377 −21.480 −12.828 1.00 15.09 N ATOM 14346 CA ALA B 402 −53.641 −22.054 −12.364 1.00 15.76 C ATOM 14348 CB ALA B 402 −54.264 −22.899 −13.454 1.00 15.57 C ATOM 14352 C ALA B 402 −53.417 −22.896 −11.129 1.00 16.63 C ATOM 14353 O ALA B 402 −54.284 −22.970 −10.259 1.00 17.00 O ATOM 14355 N TYR B 403 −52.253 −23.544 −11.060 1.00 17.50 N ATOM 14356 CA TYR B 403 −51.885 −24.317 −9.894 1.00 17.86 C ATOM 14358 CB TYR B 403 −50.486 −24.911 −10.038 1.00 17.73 C ATOM 14361 CG TYR B 403 −50.006 −25.576 −8.764 1.00 18.24 C ATOM 14362 CD1 TYR B 403 −50.401 −26.867 −8.436 1.00 18.12 C ATOM 14364 CE1 TYR B 403 −49.971 −27.476 −7.273 1.00 18.07 C ATOM 14366 CZ TYR B 403 −49.145 −26.790 −6.409 1.00 18.62 C ATOM 14367 OH TYR B 403 −48.727 −27.383 −5.244 1.00 17.70 O ATOM 14369 CE2 TYR B 403 −48.748 −25.499 −6.703 1.00 18.93 C ATOM 14371 CD2 TYR B 403 −49.177 −24.901 −7.876 1.00 18.88 C ATOM 14373 C TYR B 403 −51.966 −23.461 −8.630 1.00 18.48 C ATOM 14374 O TYR B 403 −52.494 −23.908 −7.616 1.00 18.66 O ATOM 14376 N PHE B 404 −51.468 −22.232 −8.682 1.00 18.91 N ATOM 14377 CA PHE B 404 −51.400 −21.430 −7.468 1.00 19.53 C ATOM 14379 CB PHE B 404 −50.395 −20.325 −7.644 1.00 19.35 C ATOM 14382 CG PHE B 404 −49.014 −20.808 −7.799 1.00 18.79 C ATOM 14383 CD1 PHE B 404 −48.311 −21.246 −6.701 1.00 17.67 C ATOM 14385 CE1 PHE B 404 −47.001 −21.683 −6.832 1.00 18.44 C ATOM 14387 CZ PHE B 404 −46.384 −21.688 −8.078 1.00 18.44 C ATOM 14389 CE2 PHE B 404 −47.083 −21.245 −9.190 1.00 18.79 C ATOM 14391 CD2 PHE B 404 −48.396 −20.805 −9.047 1.00 18.90 C ATOM 14393 C PHE B 404 −52.733 −20.817 −7.072 1.00 20.49 C ATOM 14394 O PHE B 404 −52.925 −20.389 −5.924 1.00 19.95 O ATOM 14396 N ALA B 405 −53.636 −20.756 −8.043 1.00 21.92 N ATOM 14397 CA ALA B 405 −54.918 −20.106 −7.872 1.00 23.09 C ATOM 14399 CB ALA B 405 −55.333 −19.426 −9.167 1.00 23.15 C ATOM 14403 C ALA B 405 −55.959 −21.113 −7.446 1.00 24.23 C ATOM 14404 O ALA B 405 −57.003 −20.726 −6.925 1.00 24.33 O ATOM 14406 N VAL B 406 −55.657 −22.399 −7.662 1.00 25.80 N ATOM 14407 CA VAL B 406 −56.569 −23.511 −7.355 1.00 26.88 C ATOM 14409 CB VAL B 406 −56.640 −24.514 −8.512 1.00 26.64 C ATOM 14411 CG1 VAL B 406 −57.132 −25.854 −8.012 1.00 27.24 C ATOM 14415 CG2 VAL B 406 −57.547 −23.986 −9.593 1.00 26.45 C ATOM 14419 C VAL B 406 −56.161 −24.266 −6.094 1.00 27.91 C ATOM 14420 O VAL B 406 −56.932 −24.345 −5.155 1.00 28.28 O ATOM 14422 N VAL B 407 −54.954 −24.825 −6.087 1.00 29.25 N ATOM 14423 CA VAL B 407 −54.443 −25.573 −4.941 1.00 30.16 C ATOM 14425 CB VAL B 407 −53.128 −26.276 −5.279 1.00 30.04 C ATOM 14427 CG1 VAL B 407 −52.482 −26.831 −4.032 1.00 30.42 C ATOM 14431 CG2 VAL B 407 −53.378 −27.376 −6.280 1.00 30.14 C ATOM 14435 C VAL B 407 −54.208 −24.646 −3.755 1.00 31.34 C ATOM 14436 O VAL B 407 −53.535 −23.618 −3.876 1.00 31.46 O ATOM 14438 N GLN B 408 −54.753 −25.032 −2.604 1.00 32.63 N ATOM 14439 CA GLN B 408 −54.727 −24.191 −1.417 1.00 33.51 C ATOM 14441 CB GLN B 408 −55.891 −24.572 −.514 1.00 33.84 C ATOM 14444 CG GLN B 408 −56.161 −23.548 .577 1.00 35.49 C ATOM 14447 CD GLN B 408 −57.623 −23.161 .656 1.00 37.61 C ATOM 14448 OE1 GLN B 408 −58.519 −24.006 .501 1.00 38.23 O ATOM 14449 NE2 GLN B 408 −57.876 −21.874 .893 1.00 38.64 N ATOM 14452 C GLN B 408 −53.399 −24.274 −.647 1.00 33.72 C ATOM 14453 O GLN B 408 −52.852 −23.253 −.204 1.00 33.52 O ATOM 14455 N ASN B 409 −52.889 −25.491 −.490 1.00 33.95 N ATOM 14456 CA ASN B 409 −51.642 −25.707 .226 1.00 34.16 C ATOM 14458 CB ASN B 409 −51.865 −26.665 1.391 1.00 34.25 C ATOM 14461 CG ASN B 409 −52.756 −26.069 2.459 1.00 34.39 C ATOM 14462 OD1 ASN B 409 −52.269 −25.577 3.480 1.00 34.40 O ATOM 14463 ND2 ASN B 409 −54.070 −26.089 2.222 1.00 34.12 N ATOM 14466 C ASN B 409 −50.582 −26.244 −.709 1.00 34.12 C ATOM 14467 O ASN B 409 −50.578 −27.422 −1.046 1.00 34.41 O ATOM 14469 N ILE B 410 −49.681 −25.369 −1.127 1.00 34.07 N ATOM 14470 CA ILE B 410 −48.699 −25.718 −2.138 1.00 34.08 C ATOM 14472 CB ILE B 410 −48.138 −24.455 −2.840 1.00 34.15 C ATOM 14474 CG1 ILE B 410 −47.274 −23.610 −1.891 1.00 34.26 C ATOM 14477 CD1 ILE B 410 −47.216 −22.139 −2.249 1.00 34.10 C ATOM 14481 CG2 ILE B 410 −49.290 −23.634 −3.404 1.00 34.49 C ATOM 14485 C ILE B 410 −47.586 −26.553 −1.533 1.00 33.93 C ATOM 14486 O ILE B 410 −47.181 −26.317 −.405 1.00 33.80 O ATOM 14488 N LYS B 411 −47.123 −27.546 −2.285 1.00 34.12 N ATOM 14489 CA LYS B 411 −46.012 −28.395 −1.874 1.00 34.45 C ATOM 14491 CB LYS B 411 −46.414 −29.873 −1.907 1.00 34.67 C ATOM 14494 CG LYS B 411 −47.850 −30.130 −1.460 1.00 35.79 C ATOM 14497 CD LYS B 411 −48.102 −31.586 −1.052 1.00 37.60 C ATOM 14500 CE LYS B 411 −49.450 −31.728 −.309 1.00 38.80 C ATOM 14503 NZ LYS B 411 −49.568 −32.992 .488 1.00 39.20 N ATOM 14507 C LYS B 411 −44.843 −28.132 −2.810 1.00 34.33 C ATOM 14508 O LYS B 411 −45.038 −27.956 −4.006 1.00 34.14 O ATOM 14510 N LYS B 412 −43.631 −28.102 −2.265 1.00 34.50 N ATOM 14511 CA LYS B 412 −42.460 −27.688 −3.042 1.00 34.69 C ATOM 14513 CB LYS B 412 −41.242 −27.398 −2.154 1.00 35.13 C ATOM 14516 CG LYS B 412 −41.205 −25.960 −1.613 1.00 36.90 C ATOM 14519 CD LYS B 412 −40.079 −25.749 −.588 1.00 38.57 C ATOM 14522 CE LYS B 412 −40.546 −24.852 .555 1.00 39.55 C ATOM 14525 NZ LYS B 412 −39.491 −24.644 1.587 1.00 40.83 N ATOM 14529 C LYS B 412 −42.075 −28.687 −4.103 1.00 34.13 C ATOM 14530 O LYS B 412 −41.468 −28.308 −5.093 1.00 34.21 O ATOM 14532 N GLU B 413 −42.408 −29.958 −3.910 1.00 33.54 N ATOM 14533 CA GLU B 413 −42.095 −30.949 −4.933 1.00 33.19 C ATOM 14535 CB GLU B 413 −41.886 −32.335 −4.330 1.00 33.44 C ATOM 14538 CG GLU B 413 −43.127 −33.037 −3.807 1.00 34.37 C ATOM 14541 CD GLU B 413 −42.834 −34.490 −3.499 1.00 35.56 C ATOM 14542 OE1 GLU B 413 −42.662 −35.264 −4.471 1.00 35.30 O ATOM 14543 OE2 GLU B 413 −42.751 −34.847 −2.297 1.00 36.69 O ATOM 14544 C GLU B 413 −43.157 −30.965 −6.029 1.00 32.47 C ATOM 14545 O GLU B 413 −42.846 −31.232 −7.193 1.00 32.28 O ATOM 14547 N GLU B 414 −44.403 −30.676 −5.652 1.00 31.58 N ATOM 14548 CA GLU B 414 −45.482 −30.512 −6.614 1.00 30.99 C ATOM 14550 CB GLU B 414 −46.781 −30.101 −5.927 1.00 30.98 C ATOM 14553 CG GLU B 414 −47.732 −31.245 −5.642 1.00 31.82 C ATOM 14556 CD GLU B 414 −49.100 −30.774 −5.138 1.00 34.29 C ATOM 14557 OE1 GLU B 414 −49.258 −29.581 −4.777 1.00 35.53 O ATOM 14558 OE2 GLU B 414 −50.036 −31.603 −5.101 1.00 36.44 O ATOM 14559 C GLU B 414 −45.104 −29.455 −7.628 1.00 30.59 C ATOM 14560 O GLU B 414 −45.169 −29.687 −8.828 1.00 30.37 O ATOM 14562 N ILE B 415 −44.684 −28.295 −7.140 1.00 30.49 N ATOM 14563 CA ILE B 415 −44.367 −27.177 −8.028 1.00 30.40 C ATOM 14565 CB ILE B 415 −44.412 −25.797 −7.320 1.00 30.40 C ATOM 14567 CG1 ILE B 415 −43.235 −25.589 −6.388 1.00 30.36 C ATOM 14570 CD1 ILE B 415 −43.373 −24.313 −5.611 1.00 31.01 C ATOM 14574 CG2 ILE B 415 −45.686 −25.644 −6.523 1.00 30.85 C ATOM 14578 C ILE B 415 −43.037 −27.347 −8.730 1.00 30.12 C ATOM 14579 O ILE B 415 −42.870 −26.865 −9.840 1.00 30.42 O ATOM 14581 N GLU B 416 −42.095 −28.030 −8.099 1.00 29.75 N ATOM 14582 CA GLU B 416 −40.799 −28.249 −8.719 1.00 29.70 C ATOM 14584 CB GLU B 416 −39.825 −28.777 −7.690 1.00 30.02 C ATOM 14587 CG GLU B 416 −38.386 −28.426 −7.948 1.00 31.20 C ATOM 14590 CD GLU B 416 −37.523 −28.839 −6.776 1.00 32.91 C ATOM 14591 OE1 GLU B 416 −38.008 −28.723 −5.632 1.00 32.37 O ATOM 14592 OE2 GLU B 416 −36.377 −29.294 −6.994 1.00 35.31 O ATOM 14593 C GLU B 416 −40.917 −29.222 −9.890 1.00 29.24 C ATOM 14594 O GLU B 416 −40.121 −29.177 −10.835 1.00 28.86 O ATOM 14596 N ASN B 417 −41.915 −30.097 −9.819 1.00 28.81 N ATOM 14597 CA ASN B 417 −42.252 −30.960 −10.941 1.00 28.66 C ATOM 14599 CB ASN B 417 −43.165 −32.105 −10.503 1.00 28.72 C ATOM 14602 CG ASN B 417 −42.379 −33.285 −9.973 1.00 29.78 C ATOM 14603 OD1 ASN B 417 −41.887 −34.108 −10.744 1.00 30.39 O ATOM 14604 ND2 ASN B 417 −42.223 −33.358 −8.653 1.00 31.45 N ATOM 14607 C ASN B 417 −42.888 −30.183 −12.067 1.00 28.32 C ATOM 14608 O ASN B 417 −42.611 −30.456 −13.232 1.00 27.95 O ATOM 14610 N LEU B 418 −43.740 −29.217 −11.713 1.00 28.23 N ATOM 14611 CA LEU B 418 −44.349 −28.313 −12.697 1.00 27.92 C ATOM 14613 CB LEU B 418 −45.298 −27.320 −12.023 1.00 27.48 C ATOM 14616 CG LEU B 418 −46.636 −27.896 −11.553 1.00 27.02 C ATOM 14618 CD1 LEU B 418 −47.393 −26.882 −10.691 1.00 26.70 C ATOM 14622 CD2 LEU B 418 −47.499 −28.355 −12.720 1.00 25.90 C ATOM 14626 C LEU B 418 −43.275 −27.567 −13.491 1.00 28.20 C ATOM 14627 O LEU B 418 −43.310 −27.541 −14.733 1.00 27.90 O ATOM 14629 N GLN B 419 −42.308 −26.995 −12.770 1.00 28.43 N ATOM 14630 CA GLN B 419 −41.170 −26.315 −13.395 1.00 28.72 C ATOM 14632 CB GLN B 419 −40.223 −25.746 −12.347 1.00 28.81 C ATOM 14635 CG GLN B 419 −40.592 −24.332 −11.946 1.00 30.14 C ATOM 14638 CD GLN B 419 −39.535 −23.671 −11.092 1.00 32.05 C ATOM 14639 OE1 GLN B 419 −39.246 −22.477 −11.257 1.00 33.88 O ATOM 14640 NE2 GLN B 419 −38.948 −24.437 −10.170 1.00 31.84 N ATOM 14643 C GLN B 419 −40.390 −27.179 −14.370 1.00 28.83 C ATOM 14644 O GLN B 419 −39.922 −26.668 −15.386 1.00 28.72 O ATOM 14646 N LYS B 420 −40.265 −28.475 −14.067 1.00 29.21 N ATOM 14647 CA LYS B 420 −39.613 −29.451 −14.968 1.00 29.26 C ATOM 14649 CB LYS B 420 −38.924 −30.555 −14.143 1.00 29.42 C ATOM 14652 CG LYS B 420 −37.800 −30.052 −13.207 1.00 30.58 C ATOM 14655 CD LYS B 420 −37.373 −31.113 −12.151 1.00 32.35 C ATOM 14658 CE LYS B 420 −36.572 −30.506 −10.955 1.00 33.05 C ATOM 14661 NZ LYS B 420 −36.520 −31.368 −9.702 1.00 32.62 N ATOM 14665 C LYS B 420 −40.579 −30.057 −16.021 1.00 28.96 C ATOM 14666 O LYS B 420 −40.216 −30.965 −16.753 1.00 28.66 O ATOM 14668 N TYR B 421 −41.804 −29.543 −16.088 1.00 29.01 N ATOM 14669 CA TYR B 421 −42.777 −29.893 −17.134 1.00 29.16 C ATOM 14671 CB TYR B 421 −42.209 −29.602 −18.534 1.00 29.48 C ATOM 14674 CG TYR B 421 −41.968 −28.127 −18.773 1.00 31.04 C ATOM 14675 CD1 TYR B 421 −43.018 −27.219 −18.716 1.00 32.54 C ATOM 14677 CE1 TYR B 421 −42.815 −25.878 −18.914 1.00 33.35 C ATOM 14679 CZ TYR B 421 −41.556 −25.413 −19.193 1.00 34.56 C ATOM 14680 OH TYR B 421 −41.377 −24.066 −19.384 1.00 37.99 O ATOM 14838 CB ILE B 431 −54.400 −31.738 −26.375 1.00 16.53 C ATOM 14840 CG1 ILE B 431 −54.225 −33.123 −25.728 1.00 16.06 C ATOM 14843 CD1 ILE B 431 −54.069 −34.212 −26.698 1.00 16.05 C ATOM 14847 CG2 ILE B 431 −55.701 −31.666 −27.149 1.00 15.49 C ATOM 14851 C ILE B 431 −53.431 −29.949 −27.748 1.00 16.35 C ATOM 14852 O ILE B 431 −53.856 −29.712 −28.860 1.00 16.74 O ATOM 14854 N PHE B 432 −53.110 −29.003 −26.881 1.00 16.15 N ATOM 14855 CA PHE B 432 −53.353 −27.577 −27.145 1.00 16.19 C ATOM 14857 CB PHE B 432 −52.811 −26.776 −25.956 1.00 16.36 C ATOM 14860 CG PHE B 432 −53.007 −25.295 −26.043 1.00 16.54 C ATOM 14861 CD1 PHE B 432 −53.869 −24.708 −26.946 1.00 16.55 C ATOM 14863 CE1 PHE B 432 −54.007 −23.334 −26.974 1.00 17.89 C ATOM 14865 CZ PHE B 432 −53.305 −22.538 −26.080 1.00 17.96 C ATOM 14867 CE2 PHE B 432 −52.461 −23.114 −25.169 1.00 17.30 C ATOM 14869 CD2 PHE B 432 −52.323 −24.482 −25.151 1.00 17.54 C ATOM 14871 C PHE B 432 −52.726 −27.104 −28.452 1.00 15.93 C ATOM 14872 O PHE B 432 −53.398 −26.525 −29.303 1.00 15.63 O ATOM 14874 N ARG B 433 −51.438 −27.387 −28.594 1.00 15.79 N ATOM 14875 CA ARG B 433 −50.674 −27.044 −29.778 1.00 15.74 C ATOM 14877 CB ARG B 433 −49.196 −27.279 −29.470 1.00 15.68 C ATOM 14880 CG ARG B 433 −48.259 −27.218 −30.665 1.00 16.39 C ATOM 14883 CD ARG B 433 −48.348 −25.919 −31.388 1.00 16.27 C ATOM 14886 NE ARG B 433 −47.969 −24.850 −30.492 1.00 17.34 N ATOM 14888 CZ ARG B 433 −48.210 −23.565 −30.703 1.00 17.89 C ATOM 14889 NH1 ARG B 433 −48.834 −23.142 −31.803 1.00 16.79 N ATOM 14892 NH2 ARG B 433 −47.805 −22.701 −29.792 1.00 18.53 N ATOM 14895 C ARG B 433 −51.114 −27.852 −31.011 1.00 15.85 C ATOM 14896 O ARG B 433 −51.197 −27.328 −32.120 1.00 15.40 O ATOM 14898 N LEU B 434 −51.381 −29.134 −30.813 1.00 16.18 N ATOM 14899 CA LEU B 434 −51.794 −29.986 −31.902 1.00 16.58 C ATOM 14901 CB LEU B 434 −51.802 −31.453 −31.468 1.00 16.79 C ATOM 14904 CG LEU B 434 −50.408 −32.055 −31.232 1.00 17.49 C ATOM 14906 CD1 LEU B 434 −50.486 −33.548 −30.864 1.00 16.63 C ATOM 14910 CD2 LEU B 434 −49.511 −31.836 −32.467 1.00 18.00 C ATOM 14914 C LEU B 434 −53.158 −29.559 −32.423 1.00 17.07 C ATOM 14915 O LEU B 434 −53.333 −29.442 −33.633 1.00 17.44 O ATOM 14917 N CYS B 435 −54.118 −29.308 −31.532 1.00 17.23 N ATOM 14918 CA CYS B 435 −55.419 −28.778 −31.947 1.00 17.44 C ATOM 14920 CB CYS B 435 −56.301 −28.529 −30.746 1.00 17.38 C ATOM 14923 SG CYS B 435 −56.825 −29.993 −29.971 1.00 17.90 S ATOM 14925 C CYS B 435 −55.295 −27.460 −32.696 1.00 17.78 C ATOM 14926 O CYS B 435 −55.978 −27.232 −33.701 1.00 17.44 O ATOM 14928 N ASN B 436 −54.442 −26.585 −32.178 1.00 18.31 N ATOM 14929 CA ASN B 436 −54.248 −25.267 −32.769 1.00 19.14 C ATOM 14931 CB ASN B 436 −53.392 −24.394 −31.844 1.00 19.31 C ATOM 14934 CG ASN B 436 −52.984 −23.068 −32.478 1.00 20.07 C ATOM 14935 OD1 ASN B 436 −53.456 −22.686 −33.555 1.00 22.72 O ATOM 14936 ND2 ASN B 436 −52.099 −22.356 −31.800 1.00 20.90 N ATOM 14939 C ASN B 436 −53.615 −25.345 −34.157 1.00 19.51 C ATOM 14940 O ASN B 436 −54.173 −24.840 −35.131 1.00 19.79 O ATOM 14942 N ASP B 437 −52.446 −25.965 −34.245 1.00 19.85 N ATOM 14943 CA ASP B 437 −51.754 −26.058 −35.517 1.00 20.01 C ATOM 14945 CB ASP B 437 −50.340 −26.638 −35.331 1.00 20.00 C ATOM 14948 CG ASP B 437 −49.397 −25.675 −34.557 1.00 21.23 C ATOM 14949 OD1 ASP B 437 −49.902 −24.749 −33.877 1.00 22.90 O ATOM 14950 OD2 ASP B 437 −48.149 −25.821 −34.632 1.00 22.18 O ATOM 14951 C ASP B 437 −52.629 −26.838 −36.512 1.00 20.00 C ATOM 14952 O ASP B 437 −52.678 −26.491 −37.695 1.00 20.02 O ATOM 14954 N LEU B 438 −53.372 −27.836 −36.021 1.00 20.02 N ATOM 14955 CA LEU B 438 −54.352 −28.558 −36.858 1.00 20.18 C ATOM 14957 CB LEU B 438 −55.144 −29.593 −36.049 1.00 19.88 C ATOM 14960 CG LEU B 438 −54.699 −31.050 −36.142 1.00 18.97 C ATOM 14962 CD1 LEU B 438 −55.537 −31.869 −35.200 1.00 18.86 C ATOM 14966 CD2 LEU B 438 −54.818 −31.585 −37.550 1.00 16.23 C ATOM 14970 C LEU B 438 −55.358 −27.644 −37.564 1.00 20.60 C ATOM 14971 O LEU B 438 −55.717 −27.889 −38.712 1.00 20.30 O ATOM 14973 N ALA B 439 −55.825 −26.620 −36.853 1.00 21.39 N ATOM 14974 CA ALA B 439 −56.802 −25.654 −37.377 1.00 21.96 C ATOM 14976 CB ALA B 439 −57.306 −24.741 −36.242 1.00 21.77 C ATOM 14980 C ALA B 439 −56.214 −24.805 −38.494 1.00 22.47 C ATOM 14981 O ALA B 439 −56.850 −24.559 −39.517 1.00 22.13 O ATOM 14983 N SER B 440 −54.983 −24.370 −38.282 1.00 23.40 N ATOM 14984 CA SER B 440 −54.337 −23.428 −39.169 1.00 24.40 C ATOM 14986 CB SER B 440 −53.423 −22.529 −38.342 1.00 24.44 C ATOM 14989 OG SER B 440 −52.994 −23.206 −37.166 1.00 25.19 O ATOM 14991 C SER B 440 −53.544 −24.103 −40.289 1.00 25.15 C ATOM 14992 O SER B 440 −53.093 −23.424 −41.210 1.00 25.24 O ATOM 14994 N ALA B 441 −53.392 −25.428 −40.222 1.00 25.99 N ATOM 14995 CA ALA B 441 −52.488 −26.160 −41.119 1.00 26.53 C ATOM 14997 CB ALA B 441 −52.532 −27.655 −40.830 1.00 26.26 C ATOM 15001 C ALA B 441 −52.726 −25.903 −42.608 1.00 27.31 C ATOM 15002 O ALA B 441 −51.811 −25.489 −43.310 1.00 27.26 O ATOM 15004 N SER B 442 −53.940 −26.134 −43.098 1.00 28.45 N ATOM 15005 CA SER B 442 −54.138 −26.138 −44.545 1.00 29.47 C ATOM 15007 CB SER B 442 −55.477 −26.769 −44.936 1.00 29.40 C ATOM 15010 OG SER B 442 −56.454 −25.784 −45.181 1.00 30.36 O ATOM 15012 C SER B 442 −53.966 −24.731 −45.125 1.00 30.22 C ATOM 15013 O SER B 442 −53.304 −24.562 −46.139 1.00 30.26 O ATOM 15015 N ALA B 443 −54.537 −23.729 −44.467 1.00 31.38 N ATOM 15016 CA ALA B 443 −54.308 −22.333 −44.835 1.00 32.22 C ATOM 15018 CB ALA B 443 −55.057 −21.410 −43.893 1.00 32.28 C ATOM 15022 C ALA B 443 −52.820 −21.992 −44.818 1.00 33.12 C ATOM 15023 O ALA B 443 −52.302 −21.419 −45.766 1.00 33.24 O ATOM 15025 N GLU B 444 −52.136 −22.351 −43.736 1.00 34.43 N ATOM 15026 CA GLU B 444 −50.711 −22.033 −43.582 1.00 35.35 C ATOM 15028 CB GLU B 444 −50.237 −22.271 −42.134 1.00 35.46 C ATOM 15031 CG GLU B 444 −50.757 −21.227 −41.126 1.00 36.42 C ATOM 15034 CD GLU B 444 −50.178 −21.376 −39.708 1.00 37.82 C ATOM 15035 OE1 GLU B 444 −49.965 −22.506 −39.224 1.00 37.92 O ATOM 15036 OE2 GLU B 444 −49.955 −20.344 −39.049 1.00 40.09 O ATOM 15037 C GLU B 444 −49.840 −22.794 −44.594 1.00 35.87 C ATOM 15038 O GLU B 444 −48.870 −22.239 −45.107 1.00 35.85 O ATOM 15040 N ILE B 445 −50.193 −24.048 −44.883 1.00 36.63 N ATOM 15041 CA ILE B 445 −49.517 −24.837 −45.928 1.00 37.21 C ATOM 15043 CB ILE B 445 −49.854 −26.366 −45.832 1.00 37.15 C ATOM 15045 CG1 ILE B 445 −49.181 −26.991 −44.609 1.00 36.85 C ATOM 15048 CD1 ILE B 445 −49.867 −28.244 −44.102 1.00 36.62 C ATOM 15052 CG2 ILE B 445 −49.416 −27.120 −47.093 1.00 36.66 C ATOM 15056 C ILE B 445 −49.933 −24.289 −47.290 1.00 37.88 C ATOM 15057 O ILE B 445 −50.926 −24.733 −47.874 1.00 38.20 O ATOM 15059 N ALA B 446 −49.175 −23.314 −47.785 1.00 38.56 N ATOM 15060 CA ALA B 446 −49.544 −22.575 −48.992 1.00 39.03 C ATOM 15062 CB ALA B 446 −49.833 −23.522 −50.169 1.00 39.19 C ATOM 15066 C ALA B 446 −50.768 −21.740 −48.685 1.00 39.42 C ATOM 15067 O ALA B 446 −51.866 −22.288 −48.742 1.00 39.26 O ATOM 15069 N ARG B 447 −50.650 −20.443 −48.361 1.00 40.06 N ATOM 15070 CA ARG B 447 −49.426 −19.589 −48.361 1.00 40.54 C ATOM 15072 CB ARG B 447 −49.276 −18.901 −46.986 1.00 40.70 C ATOM 15075 CG ARG B 447 −50.121 −17.634 −46.836 1.00 41.82 C ATOM 15078 CD ARG B 447 −50.292 −17.234 −45.377 1.00 42.99 C ATOM 15081 NE ARG B 447 −51.628 −17.546 −44.864 1.00 44.22 N ATOM 15083 CZ ARG B 447 −51.924 −17.766 −43.580 1.00 46.00 C ATOM 15084 NH1 ARG B 447 −50.977 −17.730 −42.633 1.00 46.34 N ATOM 15087 NH2 ARG B 447 −53.184 −18.039 −43.236 1.00 46.39 N ATOM 15090 C ARG B 447 −48.095 −20.208 −48.837 1.00 40.35 C ATOM 15091 O ARG B 447 −47.897 −20.403 −50.038 1.00 40.95 O ATOM 15093 N GLY B 448 −47.170 −20.442 −47.918 1.00 39.87 N ATOM 15094 CA GLY B 448 −46.020 −21.306 −48.162 1.00 39.52 C ATOM 15097 C GLY B 448 −45.258 −21.517 −46.865 1.00 39.26 C ATOM 15098 O GLY B 448 −44.071 −21.842 −46.885 1.00 39.15 O ATOM 15100 N GLU B 449 −45.966 −21.344 −45.742 1.00 38.85 N ATOM 15101 CA GLU B 449 −45.365 −21.215 −44.426 1.00 38.45 C ATOM 15103 CB GLU B 449 −46.288 −20.472 −43.444 1.00 38.76 C ATOM 15106 CG GLU B 449 −46.346 −18.943 −43.636 1.00 40.34 C ATOM 15109 CD GLU B 449 −47.486 −18.257 −42.839 1.00 42.09 C ATOM 15110 OE1 GLU B 449 −47.897 −18.787 −41.780 1.00 43.23 O ATOM 15111 OE2 GLU B 449 −47.972 −17.184 −43.274 1.00 42.13 O ATOM 15112 C GLU B 449 −45.073 −22.600 −43.906 1.00 37.54 C ATOM 15113 O GLU B 449 −45.810 −23.553 −44.167 1.00 37.34 O ATOM 15115 N THR B 450 −43.986 −22.688 −43.159 1.00 36.47 N ATOM 15116 CA THR B 450 −43.459 −23.950 −42.702 1.00 35.65 C ATOM 15118 CB THR B 450 −42.017 −24.105 −43.245 1.00 35.81 C ATOM 15120 OG1 THR B 450 −41.593 −25.465 −43.109 1.00 37.67 O ATOM 15122 CG2 THR B 450 −41.029 −23.152 −42.538 1.00 36.21 C ATOM 15126 C THR B 450 −43.528 −24.084 −41.166 1.00 34.22 C ATOM 15127 O THR B 450 −43.165 −25.127 −40.619 1.00 34.00 O ATOM 15129 N ALA B 451 −44.024 −23.034 −40.495 1.00 32.69 N ATOM 15130 CA ALA B 451 −44.144 −22.974 −39.026 1.00 31.28 C ATOM 15132 CB ALA B 451 −43.952 −21.546 −38.545 1.00 31.06 C ATOM 15136 C ALA B 451 −45.495 −23.500 −38.547 1.00 29.97 C ATOM 15137 O ALA B 451 −46.337 −22.735 −38.082 1.00 30.08 O ATOM 15139 N ASN B 452 −45.690 −24.809 −38.656 1.00 28.19 N ATOM 15140 CA ASN B 452 −46.935 −25.444 −38.272 1.00 26.73 C ATOM 15142 CB ASN B 452 −47.929 −25.339 −39.422 1.00 26.45 C ATOM 15145 CG ASN B 452 −49.311 −25.832 −39.057 1.00 25.38 C ATOM 15146 OD1 ASN B 452 −49.608 −27.004 −39.195 1.00 24.57 O ATOM 15147 ND2 ASN B 452 −50.171 −24.928 −38.618 1.00 24.44 N ATOM 15150 C ASN B 452 −46.631 −26.889 −37.952 1.00 26.05 C ATOM 15151 O ASN B 452 −45.930 −27.544 −38.695 1.00 26.21 O ATOM 15153 N SER B 453 −47.131 −27.388 −36.834 1.00 25.30 N ATOM 15154 CA SER B 453 −46.843 −28.760 −36.432 1.00 24.72 C ATOM 15156 CB SER B 453 −47.638 −29.139 −35.174 1.00 24.81 C ATOM 15159 OG SER B 453 −47.143 −28.455 −34.031 1.00 24.36 O ATOM 15161 C SER B 453 −47.111 −29.770 −37.543 1.00 24.12 C ATOM 15162 O SER B 453 −46.325 −30.679 −37.743 1.00 24.33 O ATOM 15164 N VAL B 454 −48.202 −29.606 −38.272 1.00 23.57 N ATOM 15165 CA VAL B 454 −48.546 −30.541 −39.328 1.00 23.27 C ATOM 15167 CB VAL B 454 −50.001 −30.361 −39.795 1.00 23.06 C ATOM 15169 CG1 VAL B 454 −50.363 −31.385 −40.829 1.00 22.41 C ATOM 15173 CG2 VAL B 454 −50.946 −30.489 −38.622 1.00 22.80 C ATOM 15177 C VAL B 454 −47.581 −30.473 −40.521 1.00 23.83 C ATOM 15178 O VAL B 454 −47.370 −31.493 −41.175 1.00 24.48 O ATOM 15180 N SER B 455 −46.981 −29.309 −40.803 1.00 23.99 N ATOM 15181 CA SER B 455 −45.978 −29.198 −41.881 1.00 24.22 C ATOM 15183 CB SER B 455 −45.577 −27.767 −42.111 1.00 24.02 C ATOM 15186 OG SER B 455 −46.655 −27.098 −42.689 1.00 25.57 O ATOM 15188 C SER B 455 −44.708 −29.949 −41.582 1.00 24.65 C ATOM 15189 O SER B 455 −44.211 −30.700 −42.417 1.00 25.23 O ATOM 15191 N CYS B 456 −44.151 −29.700 −40.405 1.00 24.82 N ATOM 15192 CA CYS B 456 −43.024 −30.462 −39.935 1.00 24.81 C ATOM 15194 CB CYS B 456 −42.765 −30.170 −38.470 1.00 24.92 C ATOM 15197 SG CYS B 456 −42.139 −28.541 −38.190 1.00 25.18 S ATOM 15199 C CYS B 456 −43.304 −31.938 −40.124 1.00 24.84 C ATOM 15200 O CYS B 456 −42.507 −32.634 −40.728 1.00 25.34 O ATOM 15202 N TYR B 457 −44.442 −32.421 −39.644 1.00 24.75 N ATOM 15203 CA TYR B 457 −44.735 −33.838 −39.778 1.00 24.85 C ATOM 15205 CB TYR B 457 −46.069 −34.197 −39.142 1.00 24.64 C ATOM 15208 CG TYR B 457 −46.057 −35.537 −38.451 1.00 24.00 C ATOM 15209 CD1 TYR B 457 −45.846 −35.635 −37.083 1.00 24.19 C ATOM 15211 CE1 TYR B 457 −45.848 −36.873 −36.436 1.00 23.72 C ATOM 15213 CZ TYR B 457 −46.059 −38.025 −37.170 1.00 23.27 C ATOM 15214 OH TYR B 457 −46.063 −39.244 −36.554 1.00 22.94 O ATOM 15216 CE2 TYR B 457 −46.268 −37.961 −38.528 1.00 23.68 C ATOM 15218 CD2 TYR B 457 −46.265 −36.711 −39.163 1.00 24.16 C ATOM 15220 C TYR B 457 −44.676 −34.267 −41.251 1.00 25.30 C ATOM 15221 O TYR B 457 −43.965 −35.208 −41.584 1.00 24.94 O ATOM 15223 N MET B 458 −45.388 −33.569 −42.134 1.00 26.02 N ATOM 15224 CA MET B 458 −45.207 −33.775 −43.585 1.00 26.76 C ATOM 15226 CB MET B 458 −45.913 −32.685 −44.407 1.00 26.84 C ATOM 15229 CG MET B 458 −47.419 −32.720 −44.429 1.00 27.32 C ATOM 15232 SD MET B 458 −48.092 −31.238 −45.229 1.00 27.76 S ATOM 15233 CE MET B 458 −47.283 −31.311 −46.830 1.00 26.95 C ATOM 15237 C MET B 458 −43.723 −33.759 −43.996 1.00 27.06 C ATOM 15238 O MET B 458 −43.192 −34.746 −44.485 1.00 26.94 O ATOM 15240 N ARG B 459 −43.069 −32.624 −43.800 1.00 27.58 N ATOM 15241 CA ARG B 459 −41.720 −32.419 −44.289 1.00 28.38 C ATOM 15243 CB ARG B 459 −41.313 −30.965 −44.041 1.00 28.96 C ATOM 15246 CG ARG B 459 −39.862 −30.642 −44.328 1.00 31.93 C ATOM 15249 CD ARG B 459 −39.656 −29.139 −44.480 1.00 36.88 C ATOM 15252 NE ARG B 459 −40.318 −28.349 −43.427 1.00 41.70 N ATOM 15254 CZ ARG B 459 −39.890 −28.241 −42.161 1.00 45.68 C ATOM 15255 NH1 ARG B 459 −38.795 −28.899 −41.751 1.00 48.08 N ATOM 15258 NH2 ARG B 459 −40.566 −27.489 −41.284 1.00 45.92 N ATOM 15261 C ARG B 459 −40.717 −33.401 −43.672 1.00 28.03 C ATOM 15262 O ARG B 459 −39.829 −33.881 −44.356 1.00 28.13 O ATOM 15264 N THR B 460 −40.882 −33.711 −42.393 1.00 27.88 N ATOM 15265 CA THR B 460 −40.002 −34.635 −41.664 1.00 27.75 C ATOM 15267 CB THR B 460 −40.240 −34.502 −40.134 1.00 27.79 C ATOM 15269 OG1 THR B 460 −39.805 −33.209 −39.689 1.00 27.98 O ATOM 15271 CG2 THR B 460 −39.519 −35.589 −39.356 1.00 27.46 C ATOM 15275 C THR B 460 −40.171 −36.114 −42.045 1.00 27.72 C ATOM 15276 O THR B 460 −39.211 −36.857 −42.069 1.00 27.60 O ATOM 15278 N LYS B 461 −41.398 −36.538 −42.313 1.00 28.05 N ATOM 15279 CA LYS B 461 −41.701 −37.929 −42.649 1.00 28.25 C ATOM 15281 CB LYS B 461 −42.972 −38.381 −41.914 1.00 28.32 C ATOM 15284 CG LYS B 461 −42.767 −38.763 −40.453 1.00 28.57 C ATOM 15287 CD LYS B 461 −42.569 −40.271 −40.299 1.00 29.79 C ATOM 15290 CE LYS B 461 −41.913 −40.651 −38.970 1.00 30.32 C ATOM 15293 NZ LYS B 461 −42.651 −40.184 −37.749 1.00 30.60 N ATOM 15297 C LYS B 461 −41.876 −38.139 −44.155 1.00 28.50 C ATOM 15298 O LYS B 461 −42.071 −39.269 −44.598 1.00 28.58 O ATOM 15300 N GLY B 462 −41.818 −37.057 −44.933 1.00 28.79 N ATOM 15301 CA GLY B 462 −41.978 −37.114 −46.385 1.00 29.04 C ATOM 15304 C GLY B 462 −43.333 −37.610 −46.853 1.00 29.39 C ATOM 15305 O GLY B 462 −43.410 −38.452 −47.738 1.00 29.53 O ATOM 15307 N ILE B 463 −44.406 −37.081 −46.270 1.00 29.91 N ATOM 15308 CA ILE B 463 −45.764 −37.552 −46.572 1.00 30.27 C ATOM 15310 CB ILE B 463 −46.333 −38.444 −45.433 1.00 30.13 C ATOM 15312 CG1 ILE B 463 −46.308 −37.706 −44.092 1.00 30.22 C ATOM 15315 CD1 ILE B 463 −46.983 −38.462 −42.965 1.00 30.14 C ATOM 15319 CG2 ILE B 463 −45.558 −39.740 −45.340 1.00 29.85 C ATOM 15323 C ILE B 463 −46.775 −36.429 −46.881 1.00 30.75 C ATOM 15324 O ILE B 463 −46.595 −35.270 −46.495 1.00 30.52 O ATOM 15326 N SER B 464 −47.842 −36.822 −47.581 1.00 31.33 N ATOM 15327 CA SER B 464 −48.951 −35.944 −47.952 1.00 31.68 C ATOM 15329 CB SER B 464 −49.948 −36.709 −48.830 1.00 32.02 C ATOM 15332 OG SER B 464 −50.547 −37.793 −48.123 1.00 32.84 O ATOM 15334 C SER B 464 −49.705 −35.396 −46.747 1.00 31.62 C ATOM 15335 O SER B 464 −49.897 −36.097 −45.747 1.00 31.69 O ATOM 15337 N GLU B 465 −50.165 −34.153 −46.874 1.00 31.42 N ATOM 15338 CA GLU B 465 −50.881 −33.466 −45.803 1.00 31.20 C ATOM 15340 CB GLU B 465 −51.465 −32.141 −46.324 1.00 31.33 C ATOM 15343 CG GLU B 465 −52.441 −31.455 −45.359 1.00 31.42 C ATOM 15346 CD GLU B 465 −52.768 −30.006 −45.712 1.00 31.30 C ATOM 15347 OE1 GLU B 465 −52.325 −29.490 −46.765 1.00 30.56 O ATOM 15348 OE2 GLU B 465 −53.487 −29.380 −44.906 1.00 31.84 O ATOM 15349 C GLU B 465 −51.985 −34.325 −45.202 1.00 30.97 C ATOM 15350 O GLU B 465 −52.175 −34.327 −43.992 1.00 30.72 O ATOM 15352 N GLU B 466 −52.709 −35.052 −46.055 1.00 30.98 N ATOM 15353 CA GLU B 466 −53.865 −35.833 −45.618 1.00 30.65 C ATOM 15355 CB GLU B 466 −54.553 −36.541 −46.788 1.00 30.62 C ATOM 15358 CG GLU B 466 −55.733 −37.401 −46.336 1.00 31.50 C ATOM 15361 CD GLU B 466 −56.353 −38.240 −47.446 1.00 33.14 C ATOM 15362 OE1 GLU B 466 −56.512 −37.736 −48.581 1.00 34.40 O ATOM 15363 OE2 GLU B 466 −56.699 −39.413 −47.173 1.00 33.21 O ATOM 15364 C GLU B 466 −53.477 −36.851 −44.564 1.00 30.17 C ATOM 15365 O GLU B 466 −54.215 −37.049 −43.606 1.00 30.46 O ATOM 15367 N LEU B 467 −52.333 −37.506 −44.726 1.00 29.59 N ATOM 15368 CA LEU B 467 −51.953 −38.540 −43.769 1.00 29.19 C ATOM 15370 CB LEU B 467 −51.640 −39.869 −44.476 1.00 29.27 C ATOM 15373 CG LEU B 467 −50.356 −40.081 −45.268 1.00 29.84 C ATOM 15375 CD1 LEU B 467 −49.341 −40.761 −44.357 1.00 31.06 C ATOM 15379 CD2 LEU B 467 −50.589 −40.920 −46.523 1.00 29.47 C ATOM 15383 C LEU B 467 −50.865 −38.092 −42.794 1.00 28.54 C ATOM 15384 O LEU B 467 −50.490 −38.834 −41.894 1.00 28.28 O ATOM 15386 N ALA B 468 −50.388 −36.862 −42.962 1.00 28.04 N ATOM 15387 CA ALA B 468 −49.682 −36.158 −41.893 1.00 27.54 C ATOM 15389 CB ALA B 468 −48.922 −34.970 −42.435 1.00 27.34 C ATOM 15393 C ALA B 468 −50.711 −35.698 −40.865 1.00 27.17 C ATOM 15394 O ALA B 468 −50.482 −35.801 −39.662 1.00 27.40 O ATOM 15396 N THR B 469 −51.841 −35.182 −41.349 1.00 26.57 N ATOM 15397 CA THR B 469 −52.957 −34.795 −40.490 1.00 25.87 C ATOM 15399 CB THR B 469 −54.130 −34.297 −41.328 1.00 25.53 C ATOM 15401 OG1 THR B 469 −53.737 −33.111 −42.025 1.00 24.99 O ATOM 15403 CG2 THR B 469 −55.316 −33.993 −40.453 1.00 24.62 C ATOM 15407 C THR B 469 −53.412 −35.988 −39.669 1.00 25.95 C ATOM 15408 O THR B 469 −53.551 −35.925 −38.450 1.00 25.80 O ATOM 15410 N GLU B 470 −53.618 −37.091 −40.367 1.00 26.06 N ATOM 15411 CA GLU B 470 −54.043 −38.344 −39.756 1.00 26.10 C ATOM 15413 CB GLU B 470 −54.057 −39.436 −40.848 1.00 26.60 C ATOM 15416 CG GLU B 470 −55.038 −40.587 −40.646 1.00 28.01 C ATOM 15419 CD GLU B 470 −54.553 −41.897 −41.286 1.00 29.05 C ATOM 15420 OE1 GLU B 470 −54.298 −41.930 −42.515 1.00 27.96 O ATOM 15421 OE2 GLU B 470 −54.435 −42.892 −40.536 1.00 30.42 O ATOM 15422 C GLU B 470 −53.148 −38.746 −38.557 1.00 25.28 C ATOM 15423 O GLU B 470 −53.629 −39.266 −37.556 1.00 25.08 O ATOM 15425 N SER B 471 −51.850 −38.497 −38.654 1.00 24.70 N ATOM 15426 CA SER B 471 −50.930 −38.906 −37.599 1.00 24.26 C ATOM 15428 CB SER B 471 −49.494 −38.842 −38.085 1.00 24.11 C ATOM 15431 OG SER B 471 −49.315 −39.693 −39.186 1.00 23.98 O ATOM 15433 C SER B 471 −51.085 −38.029 −36.377 1.00 23.92 C ATOM 15434 O SER B 471 −51.240 −38.530 −35.270 1.00 24.09 O ATOM 15436 N VAL B 472 −51.032 −36.719 −36.582 1.00 23.48 N ATOM 15437 CA VAL B 472 −51.279 −35.774 −35.510 1.00 23.15 C ATOM 15439 CB VAL B 472 −51.377 −34.332 −36.045 1.00 23.03 C ATOM 15441 CG1 VAL B 472 −51.739 −33.347 −34.929 1.00 21.74 C ATOM 15445 CG2 VAL B 472 −50.067 −33.945 −36.728 1.00 22.27 C ATOM 15449 C VAL B 472 −52.572 −36.192 −34.830 1.00 23.49 C ATOM 15450 O VAL B 472 −52.663 −36.276 −33.614 1.00 23.29 O ATOM 15452 N MET B 473 −53.573 −36.508 −35.626 1.00 24.34 N ATOM 15453 CA MET B 473 −54.850 −36.901 −35.070 1.00 24.93 C ATOM 15455 CB MET B 473 −55.816 −37.266 −36.190 1.00 25.09 C ATOM 15458 CG MET B 473 −57.191 −36.788 −35.912 1.00 26.94 C ATOM 15461 SD MET B 473 −57.328 −35.035 −36.251 1.00 29.69 S ATOM 15462 CE MET B 473 −58.316 −35.080 −37.775 1.00 29.12 C ATOM 15466 C MET B 473 −54.668 −38.072 −34.100 1.00 25.00 C ATOM 15467 O MET B 473 −55.135 −38.018 −32.963 1.00 24.78 O ATOM 15469 N ASN B 474 −53.965 −39.110 −34.556 1.00 25.30 N ATOM 15470 CA ASN B 474 −53.681 −40.293 −33.738 1.00 25.55 C ATOM 15472 CB ASN B 474 −53.143 −41.439 −34.601 1.00 25.82 C ATOM 15475 CG ASN B 474 −54.243 −42.137 −35.402 1.00 27.62 C ATOM 15476 OD1 ASN B 474 −54.238 −42.102 −36.638 1.00 29.33 O ATOM 15477 ND2 ASN B 474 −55.196 −42.780 −34.697 1.00 28.58 N ATOM 15480 C ASN B 474 −52.711 −40.034 −32.592 1.00 25.20 C ATOM 15481 O ASN B 474 −52.711 −40.773 −31.621 1.00 25.71 O ATOM 15483 N LEU B 475 −51.883 −38.999 −32.704 1.00 24.65 N ATOM 15484 CA LEU B 475 −50.987 −38.595 −31.614 1.00 24.04 C ATOM 15486 CB LEU B 475 −49.939 −37.626 −32.142 1.00 23.88 C ATOM 15489 CG LEU B 475 −48.837 −37.285 −31.164 1.00 23.70 C ATOM 15491 CD1 LEU B 475 −47.936 −38.471 −31.004 1.00 23.97 C ATOM 15495 CD2 LEU B 475 −48.088 −36.104 −31.679 1.00 23.99 C ATOM 15499 C LEU B 475 −51.747 −37.940 −30.453 1.00 23.65 C ATOM 15500 O LEU B 475 −51.323 −38.014 −29.299 1.00 23.74 O ATOM 15502 N ILE B 476 −52.858 −37.282 −30.766 1.00 23.15 N ATOM 15503 CA ILE B 476 −53.728 −36.711 −29.742 1.00 22.50 C ATOM 15505 CB ILE B 476 −54.779 −35.755 −30.359 1.00 22.27 C ATOM 15507 CG1 ILE B 476 −54.099 −34.508 −30.910 1.00 20.55 C ATOM 15510 CD1 ILE B 476 −55.000 −33.671 −31.693 1.00 19.19 C ATOM 15514 CG2 ILE B 476 −55.817 −35.363 −29.336 1.00 22.15 C ATOM 15518 C ILE B 476 −54.398 −37.849 −28.985 1.00 22.40 C ATOM 15519 O ILE B 476 −54.316 −37.900 −27.767 1.00 22.32 O ATOM 15521 N ASP B 477 −55.023 −38.777 −29.708 1.00 22.37 N ATOM 15522 CA ASP B 477 −55.616 −39.975 −29.090 1.00 22.55 C ATOM 15524 CB ASP B 477 −55.996 −41.007 −30.151 1.00 22.67 C ATOM 15527 CG ASP B 477 −57.262 −40.636 −30.892 1.00 24.93 C ATOM 15528 OD1 ASP B 477 −57.690 −39.458 −30.818 1.00 28.87 O ATOM 15529 OD2 ASP B 477 −57.847 −41.523 −31.549 1.00 27.92 O ATOM 15530 C ASP B 477 −54.675 −40.622 −28.083 1.00 22.10 C ATOM 15531 O ASP B 477 −55.048 −40.877 −26.938 1.00 21.83 O ATOM 15533 N GLU B 478 −53.444 −40.867 −28.510 1.00 21.73 N ATOM 15534 CA GLU B 478 −52.472 −41.506 −27.645 1.00 21.69 C ATOM 15536 CB GLU B 478 −51.233 −41.920 −28.437 1.00 21.97 C ATOM 15539 CG GLU B 478 −50.786 −43.360 −28.150 1.00 24.18 C ATOM 15542 CD GLU B 478 −51.793 −44.429 −28.618 1.00 27.03 C ATOM 15543 OE1 GLU B 478 −51.599 −45.627 −28.285 1.00 29.15 O ATOM 15544 OE2 GLU B 478 −52.770 −44.080 −29.323 1.00 28.37 O ATOM 15545 C GLU B 478 −52.107 −40.608 −26.449 1.00 20.97 C ATOM 15546 O GLU B 478 −51.928 −41.110 −25.316 1.00 21.15 O ATOM 15548 N THR B 479 −52.031 −39.291 −26.687 1.00 19.82 N ATOM 15549 CA THR B 479 −51.787 −38.319 −25.604 1.00 18.59 C ATOM 15551 CB THR B 479 −51.587 −36.897 −26.129 1.00 17.95 C ATOM 15553 OG1 THR B 479 −50.291 −36.779 −26.712 1.00 17.43 O ATOM 15555 CG2 THR B 479 −51.654 −35.938 −25.009 1.00 17.90 C ATOM 15559 C THR B 479 −52.927 −38.342 −24.580 1.00 18.16 C ATOM 15560 O THR B 479 −52.695 −38.339 −23.383 1.00 18.06 O ATOM 15562 N TRP B 480 −54.160 −38.390 −25.057 1.00 17.77 N ATOM 15563 CA TRP B 480 −55.301 −38.493 −24.169 1.00 17.54 C ATOM 15565 CB TRP B 480 −56.605 −38.464 −24.970 1.00 17.49 C ATOM 15568 CG TRP B 480 −57.239 −37.099 −25.028 1.00 17.53 C ATOM 15569 CD1 TRP B 480 −57.150 −36.186 −26.041 1.00 17.04 C ATOM 15571 NE1 TRP B 480 −57.857 −35.067 −25.721 1.00 16.57 N ATOM 15573 CE2 TRP B 480 −58.423 −35.236 −24.484 1.00 16.41 C ATOM 15574 CD2 TRP B 480 −58.055 −36.498 −24.020 1.00 16.68 C ATOM 15575 CE3 TRP B 480 −58.507 −36.914 −22.765 1.00 16.92 C ATOM 15577 CZ3 TRP B 480 −59.300 −36.076 −22.039 1.00 16.97 C ATOM 15579 CH2 TRP B 480 −59.654 −34.823 −22.524 1.00 16.91 C ATOM 15581 CZ2 TRP B 480 −59.223 −34.383 −23.742 1.00 16.89 C ATOM 15583 C TRP B 480 −55.232 −39.760 −23.334 1.00 17.75 C ATOM 15584 O TRP B 480 −55.582 −39.747 −22.164 1.00 17.74 O ATOM 15586 N LYS B 481 −54.784 −40.861 −23.933 1.00 18.09 N ATOM 15587 CA LYS B 481 −54.721 −42.124 −23.210 1.00 18.10 C ATOM 15589 CB LYS B 481 −54.277 −43.282 −24.115 1.00 18.01 C ATOM 15592 CG LYS B 481 −55.311 −43.803 −25.114 1.00 16.89 C ATOM 15595 CD LYS B 481 −54.613 −44.663 −26.199 1.00 15.83 C ATOM 15598 CE LYS B 481 −55.587 −45.500 −27.025 1.00 14.74 C ATOM 15601 NZ LYS B 481 −55.119 −45.725 −28.413 1.00 12.34 N ATOM 15605 C LYS B 481 −53.750 −41.970 −22.054 1.00 18.46 C ATOM 15606 O LYS B 481 −53.976 −42.494 −20.969 1.00 18.44 O ATOM 15608 N LYS B 482 −52.662 −41.252 −22.279 1.00 18.80 N ATOM 15609 CA LYS B 482 −51.727 −41.019 −21.192 1.00 19.58 C ATOM 15611 CB LYS B 482 −50.425 −40.424 −21.727 1.00 20.03 C ATOM 15614 CG LYS B 482 −49.499 −41.500 −22.277 1.00 22.03 C ATOM 15617 CD LYS B 482 −48.706 −41.063 −23.506 1.00 24.87 C ATOM 15620 CE LYS B 482 −47.908 −42.268 −24.066 1.00 26.65 C ATOM 15623 NZ LYS B 482 −47.287 −41.996 −25.408 1.00 28.80 N ATOM 15627 C LYS B 482 −52.363 −40.156 −20.096 1.00 19.56 C ATOM 15628 O LYS B 482 −52.367 −40.537 −18.926 1.00 19.19 O ATOM 15630 N MET B 483 −52.922 −39.013 −20.483 1.00 20.00 N ATOM 15631 CA MET B 483 −53.677 −38.165 −19.552 1.00 20.37 C ATOM 15633 CB MET B 483 −54.426 −37.057 −20.295 1.00 20.25 C ATOM 15636 CG MET B 483 −53.529 −35.951 −20.807 1.00 20.52 C ATOM 15639 SD MET B 483 −54.461 −34.483 −21.225 1.00 20.47 S ATOM 15640 CE MET B 483 −55.361 −35.084 −22.649 1.00 22.07 C ATOM 15644 C MET B 483 −54.668 −38.981 −18.741 1.00 20.72 C ATOM 15645 O MET B 483 −54.809 −38.779 −17.543 1.00 20.37 O ATOM 15647 N ASN B 484 −55.345 −39.910 −19.403 1.00 21.57 N ATOM 15648 CA ASN B 484 −56.339 −40.731 −18.744 1.00 22.46 C ATOM 15650 CB ASN B 484 −57.042 −41.631 −19.765 1.00 22.23 C ATOM 15653 CG ASN B 484 −58.118 −40.900 −20.576 1.00 21.61 C ATOM 15654 OD1 ASN B 484 −58.412 −39.722 −20.362 1.00 20.25 O ATOM 15655 ND2 ASN B 484 −58.720 −41.622 −21.510 1.00 20.80 N ATOM 15658 C ASN B 484 −55.723 −41.555 −17.598 1.00 23.83 C ATOM 15659 O ASN B 484 −56.262 −41.591 −16.484 1.00 23.76 O ATOM 15661 N LYS B 485 −54.585 −42.190 −17.868 1.00 25.69 N ATOM 15662 CA LYS B 485 −53.854 −42.937 −16.843 1.00 27.11 C ATOM 15664 CB LYS B 485 −52.679 −43.712 −17.447 1.00 27.13 C ATOM 15667 CG LYS B 485 −52.073 −44.755 −16.489 1.00 28.85 C ATOM 15670 CD LYS B 485 −51.643 −46.082 −17.187 1.00 31.17 C ATOM 15673 CE LYS B 485 −50.150 −46.132 −17.555 1.00 32.11 C ATOM 15676 NZ LYS B 485 −49.291 −46.282 −16.344 1.00 33.08 N ATOM 15680 C LYS B 485 −53.370 −42.035 −15.701 1.00 28.37 C ATOM 15681 O LYS B 485 −53.288 −42.481 −14.563 1.00 28.59 O ATOM 15683 N GLU B 486 −53.083 −40.766 −15.980 1.00 29.89 N ATOM 15684 CA GLU B 486 −52.683 −39.849 −14.910 1.00 31.09 C ATOM 15686 CB GLU B 486 −52.174 −38.511 −15.470 1.00 31.55 C ATOM 15689 CG GLU B 486 −51.059 −37.851 −14.643 1.00 32.69 C ATOM 15692 CD GLU B 486 −49.785 −38.689 −14.605 1.00 34.51 C ATOM 15693 OE1 GLU B 486 −49.104 −38.682 −13.557 1.00 36.35 O ATOM 15694 OE2 GLU B 486 −49.476 −39.368 −15.611 1.00 34.55 O ATOM 15695 C GLU B 486 −53.836 −39.615 −13.939 1.00 31.70 C ATOM 15696 O GLU B 486 −53.684 −39.868 −12.750 1.00 31.90 O ATOM 15698 N LYS B 487 −54.983 −39.164 −14.453 1.00 32.71 N ATOM 15699 CA LYS B 487 −56.177 −38.856 −13.629 1.00 33.57 C ATOM 15701 CB LYS B 487 −57.343 −38.402 −14.519 1.00 33.54 C ATOM 15704 CG LYS B 487 −58.703 −38.196 −13.823 1.00 33.45 C ATOM 15707 CD LYS B 487 −58.686 −37.024 −12.866 1.00 33.71 C ATOM 15710 CE LYS B 487 −59.906 −36.996 −11.931 1.00 34.48 C ATOM 15713 NZ LYS B 487 −61.123 −36.378 −12.526 1.00 35.03 N ATOM 15717 C LYS B 487 −56.626 −40.046 −12.802 1.00 34.60 C ATOM 15718 O LYS B 487 −57.126 −39.892 −11.681 1.00 34.55 O ATOM 15720 N LEU B 488 −56.453 −41.233 −13.371 1.00 35.94 N ATOM 15721 CA LEU B 488 −56.878 −42.451 −12.723 1.00 37.00 C ATOM 15723 CB LEU B 488 −57.280 −43.489 −13.778 1.00 36.90 C ATOM 15726 CG LEU B 488 −58.081 −44.714 −13.312 1.00 37.52 C ATOM 15728 CD1 LEU B 488 −58.758 −44.536 −11.946 1.00 38.76 C ATOM 15732 CD2 LEU B 488 −59.121 −45.084 −14.346 1.00 38.42 C ATOM 15736 C LEU B 488 −55.786 −42.980 −11.803 1.00 38.02 C ATOM 15737 O LEU B 488 −56.063 −43.315 −10.653 1.00 38.19 O ATOM 15739 N GLY B 489 −54.550 −43.016 −12.298 1.00 39.44 N ATOM 15740 CA GLY B 489 −53.441 −43.710 −11.621 1.00 40.62 C ATOM 15743 C GLY B 489 −52.563 −42.837 −10.740 1.00 41.76 C ATOM 15744 O GLY B 489 −51.357 −42.703 −10.988 1.00 41.83 O ATOM 15746 N GLY B 490 −53.183 −42.230 −9.726 1.00 43.10 N ATOM 15747 CA GLY B 490 −52.481 −41.538 −8.636 1.00 43.82 C ATOM 15750 C GLY B 490 −51.131 −40.924 −8.967 1.00 44.31 C ATOM 15751 O GLY B 490 −50.084 −41.560 −8.831 1.00 44.25 O ATOM 15753 N SER B 491 −51.161 −39.672 −9.396 1.00 44.87 N ATOM 15754 CA SER B 491 −49.939 −38.892 −9.575 1.00 45.22 C ATOM 15756 CB SER B 491 −50.224 −37.723 −10.537 1.00 45.34 C ATOM 15759 OG SER B 491 −51.411 −37.032 −10.166 1.00 45.38 O ATOM 15761 C SER B 491 −49.419 −38.389 −8.203 1.00 45.14 C ATOM 15762 O SER B 491 −49.896 −38.824 −7.140 1.00 45.11 O ATOM 15764 N LEU B 492 −48.429 −37.491 −8.227 1.00 44.77 N ATOM 15765 CA LEU B 492 −48.046 −36.752 −7.018 1.00 44.31 C ATOM 15767 CB LEU B 492 −46.726 −35.971 −7.188 1.00 44.55 C ATOM 15770 CG LEU B 492 −45.530 −36.546 −7.972 1.00 45.73 C ATOM 15772 CD1 LEU B 492 −44.373 −35.556 −7.859 1.00 46.25 C ATOM 15776 CD2 LEU B 492 −45.084 −37.972 −7.530 1.00 46.14 C ATOM 15780 C LEU B 492 −49.151 −35.760 −6.703 1.00 43.30 C ATOM 15781 O LEU B 492 −49.315 −35.370 −5.555 1.00 43.49 O ATOM 15783 N PHE B 493 −49.903 −35.367 −7.735 1.00 42.05 N ATOM 15784 CA PHE B 493 −50.822 −34.239 −7.668 1.00 41.03 C ATOM 15786 CB PHE B 493 −50.913 −33.549 −9.028 1.00 40.81 C ATOM 15789 CG PHE B 493 −49.696 −32.771 −9.408 1.00 38.96 C ATOM 15790 CD1 PHE B 493 −49.651 −31.408 −9.233 1.00 37.06 C ATOM 15792 CE1 PHE B 493 −48.543 −30.697 −9.603 1.00 36.41 C ATOM 15794 CZ PHE B 493 −47.471 −31.341 −10.158 1.00 35.87 C ATOM 15796 CE2 PHE B 493 −47.507 −32.690 −10.343 1.00 36.39 C ATOM 15798 CD2 PHE B 493 −48.612 −33.400 −9.977 1.00 37.36 C ATOM 15800 C PHE B 493 −52.240 −34.603 −7.268 1.00 40.76 C ATOM 15801 O PHE B 493 −52.686 −35.733 −7.419 1.00 40.35 O ATOM 15803 N ALA B 494 −52.943 −33.584 −6.790 1.00 40.72 N ATOM 15804 CA ALA B 494 −54.355 −33.658 −6.471 1.00 40.68 C ATOM 15806 CB ALA B 494 −54.786 −32.362 −5.770 1.00 40.70 C ATOM 15810 C ALA B 494 −55.175 −33.851 −7.744 1.00 40.59 C ATOM 15811 O ALA B 494 −55.013 −33.099 −8.716 1.00 40.95 O ATOM 15813 N LYS B 495 −56.071 −34.835 −7.733 1.00 40.12 N ATOM 15814 CA LYS B 495 −57.000 −35.047 −8.854 1.00 39.67 C ATOM 15816 CB LYS B 495 −58.008 −36.166 −8.520 1.00 39.98 C ATOM 15819 CG LYS B 495 −57.388 −37.590 −8.496 1.00 40.57 C ATOM 15822 CD LYS B 495 −58.468 −38.688 −8.419 1.00 41.18 C ATOM 15825 CE LYS B 495 −57.878 −40.065 −8.132 1.00 41.28 C ATOM 15828 NZ LYS B 495 −58.736 −41.159 −8.671 1.00 41.39 N ATOM 15832 C LYS B 495 −57.717 −33.752 −9.333 1.00 38.82 C ATOM 15833 O LYS B 495 −57.847 −33.535 −10.537 1.00 38.70 O ATOM 15835 N PRO B 496 −58.169 −32.890 −8.397 1.00 37.71 N ATOM 15836 CA PRO B 496 −58.701 −31.551 −8.687 1.00 36.80 C ATOM 15838 CB PRO B 496 −58.820 −30.937 −7.304 1.00 36.94 C ATOM 15841 CG PRO B 496 −59.255 −32.073 −6.483 1.00 37.90 C ATOM 15844 CD PRO B 496 −58.534 −33.294 −7.030 1.00 37.86 C ATOM 15847 C PRO B 496 −57.845 −30.625 −9.536 1.00 35.57 C ATOM 15848 O PRO B 496 −58.389 −29.693 −10.139 1.00 35.93 O ATOM 15849 N PHE B 497 −56.527 −30.836 −9.546 1.00 33.52 N ATOM 15850 CA PHE B 497 −55.654 −30.083 −10.439 1.00 31.34 C ATOM 15852 CB PHE B 497 −54.355 −29.710 −9.750 1.00 30.86 C ATOM 15855 CG PHE B 497 −53.394 −28.989 −10.634 1.00 29.04 C ATOM 15856 CD1 PHE B 497 −53.639 −27.700 −11.022 1.00 27.89 C ATOM 15858 CE1 PHE B 497 −52.752 −27.028 −11.834 1.00 27.39 C ATOM 15860 CZ PHE B 497 −51.599 −27.653 −12.259 1.00 27.40 C ATOM 15862 CE2 PHE B 497 −51.341 −28.941 −11.877 1.00 27.44 C ATOM 15864 CD2 PHE B 497 −52.236 −29.604 −11.074 1.00 28.18 C ATOM 15866 C PHE B 497 −55.390 −30.870 −11.714 1.00 30.24 C ATOM 15867 O PHE B 497 −55.301 −30.266 −12.786 1.00 30.39 O ATOM 15869 N VAL B 498 −55.295 −32.200 −11.630 1.00 28.50 N ATOM 15870 CA VAL B 498 −55.076 −32.983 −12.854 1.00 27.54 C ATOM 15872 CB VAL B 498 −54.778 −34.472 −12.611 1.00 27.34 C ATOM 15874 CG1 VAL B 498 −56.027 −35.194 −12.262 1.00 28.14 C ATOM 15878 CG2 VAL B 498 −53.731 −34.649 −11.530 1.00 27.04 C ATOM 15882 C VAL B 498 −56.277 −32.857 −13.784 1.00 26.60 C ATOM 15883 O VAL B 498 −56.129 −32.864 −14.995 1.00 26.33 O ATOM 15885 N GLU B 499 −57.468 −32.731 −13.214 1.00 25.87 N ATOM 15886 CA GLU B 499 −58.662 −32.484 −14.022 1.00 25.20 C ATOM 15888 CB GLU B 499 −59.975 −32.639 −13.206 1.00 25.26 C ATOM 15891 CG GLU B 499 −61.287 −32.694 −14.028 1.00 25.16 C ATOM 15894 CD GLU B 499 −61.422 −33.922 −14.973 1.00 26.79 C ATOM 15895 OE1 GLU B 499 −60.607 −34.880 −14.928 1.00 26.39 O ATOM 15896 OE2 GLU B 499 −62.379 −33.926 −15.785 1.00 27.83 O ATOM 15897 C GLU B 499 −58.542 −31.097 −14.641 1.00 24.27 C ATOM 15898 O GLU B 499 −58.819 −30.948 −15.832 1.00 24.32 O ATOM 15900 N THR B 500 −58.098 −30.093 −13.882 1.00 22.90 N ATOM 15901 CA THR B 500 −58.027 −28.764 −14.487 1.00 22.29 C ATOM 15903 CB THR B 500 −57.908 −27.592 −13.488 1.00 22.43 C ATOM 15905 OG1 THR B 500 −56.536 −27.259 −13.274 1.00 22.65 O ATOM 15907 CG2 THR B 500 −58.614 −27.899 −12.183 1.00 22.84 C ATOM 15911 C THR B 500 −56.940 −28.671 −15.565 1.00 21.20 C ATOM 15912 O THR B 500 −57.120 −27.939 −16.536 1.00 21.06 O ATOM 15914 N ALA B 501 −55.845 −29.414 −15.422 1.00 19.88 N ATOM 15915 CA ALA B 501 −54.906 −29.574 −16.537 1.00 19.24 C ATOM 15917 CB ALA B 501 −53.704 −30.393 −16.115 1.00 19.22 C ATOM 15921 C ALA B 501 −55.581 −30.226 −17.757 1.00 18.68 C ATOM 15922 O ALA B 501 −55.427 −29.768 −18.881 1.00 18.32 O ATOM 15924 N ILE B 502 −56.324 −31.300 −17.523 1.00 18.11 N ATOM 15925 CA ILE B 502 −57.023 −31.988 −18.591 1.00 17.68 C ATOM 15927 CB ILE B 502 −57.750 −33.251 −18.059 1.00 17.63 C ATOM 15929 CG1 ILE B 502 −56.713 −34.350 −17.769 1.00 18.16 C ATOM 15932 CD1 ILE B 502 −57.253 −35.645 −17.115 1.00 17.02 C ATOM 15936 CG2 ILE B 502 −58.756 −33.762 −19.063 1.00 16.93 C ATOM 15940 C ILE B 502 −57.990 −31.030 −19.289 1.00 17.50 C ATOM 15941 O ILE B 502 −58.153 −31.071 −20.512 1.00 17.62 O ATOM 15943 N ASN B 503 −58.604 −30.139 −18.524 1.00 17.23 N ATOM 15944 CA ASN B 503 −59.545 −29.184 −19.102 1.00 17.07 C ATOM 15946 CB ASN B 503 −60.184 −28.327 −18.016 1.00 17.21 C ATOM 15949 CG ASN B 503 −61.155 −29.094 −17.176 1.00 17.29 C ATOM 15950 OD1 ASN B 503 −61.721 −30.097 −17.609 1.00 16.66 O ATOM 15951 ND2 ASN B 503 −61.365 −28.621 −15.958 1.00 19.16 N ATOM 15954 C ASN B 503 −58.920 −28.270 −20.149 1.00 16.59 C ATOM 15955 O ASN B 503 −59.611 −27.811 −21.071 1.00 16.67 O ATOM 15957 N LEU B 504 −57.629 −27.992 −20.014 1.00 15.79 N ATOM 15958 CA LEU B 504 −56.948 −27.204 −21.031 1.00 15.44 C ATOM 15960 CB LEU B 504 −55.530 −26.865 −20.609 1.00 15.07 C ATOM 15963 CG LEU B 504 −54.933 −25.837 −21.552 1.00 14.21 C ATOM 15965 CD1 LEU B 504 −54.246 −24.726 −20.800 1.00 14.21 C ATOM 15969 CD2 LEU B 504 −54.000 −26.538 −22.462 1.00 14.27 C ATOM 15973 C LEU B 504 −56.954 −27.933 −22.375 1.00 15.59 C ATOM 15974 O LEU B 504 −57.177 −27.323 −23.414 1.00 15.30 O ATOM 15976 N ALA B 505 −56.732 −29.242 −22.341 1.00 15.89 N ATOM 15977 CA ALA B 505 −56.914 −30.073 −23.514 1.00 16.23 C ATOM 15979 CB ALA B 505 −56.608 −31.483 −23.188 1.00 16.05 C ATOM 15983 C ALA B 505 −58.352 −29.955 −24.010 1.00 16.69 C ATOM 15984 O ALA B 505 −58.598 −29.738 −25.204 1.00 16.88 O ATOM 15986 N ARG B 506 −59.300 −30.071 −23.090 1.00 16.88 N ATOM 15987 CA ARG B 506 −60.709 −29.972 −23.457 1.00 17.20 C ATOM 15989 CB ARG B 506 −61.630 −30.170 −22.248 1.00 17.34 C ATOM 15992 CG ARG B 506 −61.549 −31.537 −21.614 1.00 17.46 C ATOM 15995 CD ARG B 506 −62.837 −31.917 −20.962 1.00 17.48 C ATOM 15998 NE ARG B 506 −62.783 −33.280 −20.435 1.00 18.37 N ATOM 16000 CZ ARG B 506 −62.404 −33.613 −19.201 1.00 19.03 C ATOM 16001 NH1 ARG B 506 −62.008 −32.690 −18.324 1.00 18.83 N ATOM 16004 NH2 ARG B 506 −62.415 −34.892 −18.841 1.00 19.72 N ATOM 16007 C ARG B 506 −61.038 −28.646 −24.114 1.00 17.32 C ATOM 16008 O ARG B 506 −61.754 −28.622 −25.111 1.00 17.41 O ATOM 16010 N GLN B 507 −60.540 −27.543 −23.564 1.00 17.59 N ATOM 16011 CA GLN B 507 −60.864 −26.233 −24.139 1.00 18.05 C ATOM 16013 CB GLN B 507 −60.382 −25.090 −23.258 1.00 18.16 C ATOM 16016 CG GLN B 507 −60.798 −23.709 −23.764 1.00 17.57 C ATOM 16019 CD GLN B 507 −62.291 −23.508 −23.723 1.00 17.42 C ATOM 16020 OE1 GLN B 507 −62.953 −23.959 −22.800 1.00 17.55 O ATOM 16021 NE2 GLN B 507 −62.832 −22.823 −24.722 1.00 17.56 N ATOM 16024 C GLN B 507 −60.258 −26.060 −25.521 1.00 18.49 C ATOM 16025 O GLN B 507 −60.855 −25.413 −26.380 1.00 18.73 O ATOM 16027 N SER B 508 −59.066 −26.619 −25.724 1.00 18.85 N ATOM 16028 CA SER B 508 −58.427 −26.621 −27.037 1.00 19.07 C ATOM 16030 CB SER B 508 −57.108 −27.364 −26.969 1.00 19.04 C ATOM 16033 OG SER B 508 −56.304 −26.772 −25.979 1.00 20.10 O ATOM 16035 C SER B 508 −59.305 −27.296 −28.065 1.00 19.12 C ATOM 16036 O SER B 508 −59.438 −26.827 −29.187 1.00 19.00 O ATOM 16038 N HIS B 509 −59.905 −28.409 −27.674 1.00 19.26 N ATOM 16039 CA HIS B 509 −60.814 −29.095 −28.559 1.00 19.33 C ATOM 16041 CB HIS B 509 −61.275 −30.412 −27.959 1.00 19.30 C ATOM 16044 CG HIS B 509 −60.263 −31.501 −28.067 1.00 18.71 C ATOM 16045 ND1 HIS B 509 −59.941 −32.089 −29.267 1.00 18.57 N ATOM 16047 CE1 HIS B 509 −59.020 −33.012 −29.064 1.00 19.07 C ATOM 16049 NE2 HIS B 509 −58.738 −33.044 −27.774 1.00 18.52 N ATOM 16051 CD2 HIS B 509 −59.499 −32.105 −27.129 1.00 18.43 C ATOM 16053 C HIS B 509 −62.017 −28.251 −28.878 1.00 19.60 C ATOM 16054 O HIS B 509 −62.491 −28.286 −29.969 1.00 19.68 O ATOM 16056 N CYS B 510 −62.540 −27.502 −27.932 1.00 20.12 N ATOM 16057 CA CYS B 510 −63.748 −26.738 −28.216 1.00 20.63 C ATOM 16059 CB CYS B 510 −64.493 −26.492 −26.915 1.00 20.70 C ATOM 16062 SG CYS B 510 −64.856 −28.020 −26.065 1.00 22.93 S ATOM 16064 C CYS B 510 −63.465 −25.422 −28.950 1.00 20.55 C ATOM 16065 O CYS B 510 −64.338 −24.881 −29.622 1.00 20.16 O ATOM 16067 N THR B 511 −62.236 −24.933 −28.827 1.00 20.89 N ATOM 16068 CA THR B 511 −61.833 −23.654 −29.378 1.00 21.32 C ATOM 16070 CB THR B 511 −60.682 −23.107 −28.550 1.00 20.76 C ATOM 16072 OG1 THR B 511 −61.208 −22.619 −27.324 1.00 19.50 O ATOM 16074 CG2 THR B 511 −59.961 −21.994 −29.253 1.00 19.79 C ATOM 16078 C THR B 511 −61.417 −23.735 −30.851 1.00 23.11 C ATOM 16079 O THR B 511 −61.910 −22.992 −31.694 1.00 22.75 O ATOM 16081 N TYR B 512 −60.501 −24.646 −31.152 1.00 25.46 N ATOM 16082 CA TYR B 512 −59.867 −24.704 −32.462 1.00 27.09 C ATOM 16084 CB TYR B 512 −58.397 −25.107 −32.327 1.00 27.16 C ATOM 16087 CG TYR B 512 −57.598 −24.056 −31.582 1.00 27.26 C ATOM 16088 CD1 TYR B 512 −57.300 −22.834 −32.182 1.00 28.18 C ATOM 16090 CE1 TYR B 512 −56.583 −21.844 −31.511 1.00 27.98 C ATOM 16092 CZ TYR B 512 −56.164 −22.068 −30.226 1.00 27.72 C ATOM 16093 OH TYR B 512 −55.462 −21.072 −29.584 1.00 27.09 O ATOM 16095 CE2 TYR B 512 −56.453 −23.281 −29.602 1.00 27.52 C ATOM 16097 CD2 TYR B 512 −57.171 −24.262 −30.278 1.00 26.68 C ATOM 16099 C TYR B 512 −60.633 −25.623 −33.382 1.00 28.79 C ATOM 16100 O TYR B 512 −61.050 −25.179 −34.444 1.00 28.98 O ATOM 16102 N HIS B 513 −60.789 −26.893 −32.991 1.00 31.06 N ATOM 16103 CA HIS B 513 −61.865 −27.800 −33.492 1.00 33.07 C ATOM 16105 CB HIS B 513 −62.740 −28.208 −32.265 1.00 33.66 C ATOM 16108 CG HIS B 513 −64.181 −28.602 −32.535 1.00 34.73 C ATOM 16109 ND1 HIS B 513 −65.035 −27.903 −33.367 1.00 35.70 N ATOM 16111 CE1 HIS B 513 −66.234 −28.464 −33.343 1.00 35.40 C ATOM 16113 NE2 HIS B 513 −66.206 −29.469 −32.491 1.00 35.10 N ATOM 16115 CD2 HIS B 513 −64.943 −29.565 −31.956 1.00 35.07 C ATOM 16117 C HIS B 513 −62.692 −27.179 −34.623 1.00 34.03 C ATOM 16118 O HIS B 513 −63.003 −27.848 −35.627 1.00 34.55 O ATOM 16120 N ASN B 514 −63.047 −25.906 −34.444 1.00 34.65 N ATOM 16121 CA ASN B 514 −63.713 −25.123 −35.483 1.00 35.15 C ATOM 16123 CB ASN B 514 −63.845 −23.643 −35.070 1.00 35.01 C ATOM 16126 CG ASN B 514 −64.704 −23.456 −33.820 1.00 33.48 C ATOM 16127 OD1 ASN B 514 −64.787 −24.343 −32.968 1.00 30.92 O ATOM 16128 ND2 ASN B 514 −65.327 −22.295 −33.703 1.00 32.16 N ATOM 16131 C ASN B 514 −63.192 −25.274 −36.942 1.00 36.08 C ATOM 16132 O ASN B 514 −62.010 −25.051 −37.254 1.00 35.69 O ATOM 16134 N GLY B 515 −64.119 −25.765 −37.772 1.00 37.15 N ATOM 16135 CA GLY B 515 −64.224 −25.493 −39.177 1.00 37.94 C ATOM 16138 C GLY B 515 −65.269 −24.384 −39.284 1.00 39.01 C ATOM 16139 O GLY B 515 −64.904 −23.286 −39.702 1.00 39.58 O ATOM 16141 N ASP B 516 −66.550 −24.585 −38.909 1.00 39.95 N ATOM 16142 CA ASP B 516 −67.167 −25.810 −38.349 1.00 40.65 C ATOM 16144 CB ASP B 516 −67.296 −25.652 −36.836 1.00 41.09 C ATOM 16147 CG ASP B 516 −66.318 −26.511 −36.063 1.00 43.63 C ATOM 16148 OD1 ASP B 516 −65.697 −27.434 −36.662 1.00 45.83 O ATOM 16149 OD2 ASP B 516 −66.152 −26.246 −34.843 1.00 47.12 O ATOM 16150 C ASP B 516 −68.603 −26.067 −38.853 1.00 40.78 C ATOM 16151 O ASP B 516 −69.134 −25.301 −39.660 1.00 41.28 O ATOM 16153 N ALA B 517 −69.222 −27.141 −38.349 1.00 40.66 N ATOM 16154 CA ALA B 517 −70.675 −27.396 −38.468 1.00 40.60 C ATOM 16156 CB ALA B 517 −71.422 −26.622 −37.359 1.00 40.27 C ATOM 16160 C ALA B 517 −71.295 −27.106 −39.862 1.00 40.79 C ATOM 16161 O ALA B 517 −70.654 −27.296 −40.899 1.00 40.67 O ATOM 16163 N HIS B 518 −72.562 −26.696 −39.874 1.00 41.13 N ATOM 16164 CA HIS B 518 −73.162 −26.033 −41.039 1.00 41.60 C ATOM 16166 CB HIS B 518 −74.446 −26.756 −41.480 1.00 42.24 C ATOM 16169 CG HIS B 518 −74.207 −28.179 −41.910 1.00 45.54 C ATOM 16170 ND1 HIS B 518 −73.441 −28.509 −43.012 1.00 48.51 N ATOM 16172 CE1 HIS B 518 −73.392 −29.825 −43.140 1.00 48.79 C ATOM 16174 NE2 HIS B 518 −74.092 −30.364 −42.156 1.00 49.12 N ATOM 16176 CD2 HIS B 518 −74.608 −29.357 −41.369 1.00 48.28 C ATOM 16178 C HIS B 518 −73.377 −24.545 −40.686 1.00 40.84 C ATOM 16179 O HIS B 518 −74.487 −23.997 −40.769 1.00 40.60 O ATOM 16181 N THR B 519 −72.261 −23.932 −40.275 1.00 40.10 N ATOM 16182 CA THR B 519 −72.143 −22.521 −39.878 1.00 39.39 C ATOM 16184 CB THR B 519 −72.561 −22.263 −38.393 1.00 39.40 C ATOM 16186 OG1 THR B 519 −71.823 −23.131 −37.517 1.00 39.55 O ATOM 16188 CG2 THR B 519 −74.074 −22.460 −38.178 1.00 38.98 C ATOM 16192 C THR B 519 −70.654 −22.164 −40.059 1.00 38.81 C ATOM 16193 O THR B 519 −69.800 −23.050 −40.067 1.00 38.48 O ATOM 16195 N SER B 520 −70.338 −20.881 −40.199 1.00 38.19 N ATOM 16196 CA SER B 520 −68.959 −20.453 −40.521 1.00 37.77 C ATOM 16198 CB SER B 520 −68.983 −18.976 −40.960 1.00 37.76 C ATOM 16201 OG SER B 520 −68.760 −18.106 −39.870 1.00 38.49 O ATOM 16203 C SER B 520 −67.974 −20.724 −39.340 1.00 37.24 C ATOM 16204 O SER B 520 −68.394 −21.267 −38.320 1.00 36.89 O ATOM 16206 N PRO B 521 −66.671 −20.350 −39.472 1.00 36.96 N ATOM 16207 CA PRO B 521 −65.692 −20.638 −38.396 1.00 36.80 C ATOM 16209 CB PRO B 521 −64.320 −20.354 −39.041 1.00 36.68 C ATOM 16212 CG PRO B 521 −64.599 −19.593 −40.309 1.00 37.19 C ATOM 16215 CD PRO B 521 −66.091 −19.469 −40.507 1.00 37.10 C ATOM 16218 C PRO B 521 −65.915 −19.763 −37.168 1.00 36.68 C ATOM 16219 O PRO B 521 −66.233 −20.289 −36.105 1.00 36.90 O ATOM 16220 N ASP B 522 −65.744 −18.445 −37.298 1.00 36.61 N ATOM 16221 CA ASP B 522 −66.373 −17.528 −36.347 1.00 36.58 C ATOM 16223 CB ASP B 522 −65.938 −16.070 −36.543 1.00 36.82 C ATOM 16226 CG ASP B 522 −64.456 −15.846 −36.243 1.00 37.94 C ATOM 16227 OD1 ASP B 522 −63.848 −16.627 −35.473 1.00 39.62 O ATOM 16228 OD2 ASP B 522 −63.891 −14.876 −36.790 1.00 39.40 O ATOM 16229 C ASP B 522 −67.836 −17.718 −36.681 1.00 36.12 C ATOM 16230 O ASP B 522 −68.150 −18.306 −37.702 1.00 35.98 O ATOM 16232 N GLU B 523 −68.732 −17.249 −35.830 1.00 35.69 N ATOM 16233 CA GLU B 523 −70.152 −17.605 −35.927 1.00 35.46 C ATOM 16235 CB GLU B 523 −70.703 −17.560 −37.379 1.00 35.51 C ATOM 16238 CG GLU B 523 −70.535 −16.175 −38.061 1.00 36.11 C ATOM 16241 CD GLU B 523 −70.854 −16.136 −39.572 1.00 36.72 C ATOM 16242 OE1 GLU B 523 −71.848 −16.767 −40.013 1.00 37.20 O ATOM 16243 OE2 GLU B 523 −70.101 −15.452 −40.314 1.00 35.53 O ATOM 16244 C GLU B 523 −70.440 −18.943 −35.216 1.00 34.97 C ATOM 16245 O GLU B 523 −71.557 −19.148 −34.765 1.00 35.02 O ATOM 16247 N LEU B 524 −69.462 −19.846 −35.099 1.00 34.59 N ATOM 16248 CA LEU B 524 −69.503 −20.832 −34.004 1.00 34.45 C ATOM 16250 CB LEU B 524 −68.735 −22.136 −34.286 1.00 34.21 C ATOM 16253 CG LEU B 524 −69.530 −23.434 −34.508 1.00 33.92 C ATOM 16255 CD1 LEU B 524 −68.657 −24.627 −34.227 1.00 32.21 C ATOM 16259 CD2 LEU B 524 −70.794 −23.520 −33.641 1.00 34.06 C ATOM 16263 C LEU B 524 −68.901 −20.162 −32.791 1.00 34.38 C ATOM 16264 O LEU B 524 −69.535 −20.067 −31.741 1.00 34.49 O ATOM 16266 N THR B 525 −67.670 −19.688 −32.958 1.00 34.30 N ATOM 16267 CA THR B 525 −66.913 −19.073 −31.874 1.00 34.23 C ATOM 16269 CB THR B 525 −65.570 −18.524 −32.380 1.00 34.04 C ATOM 16271 OG1 THR B 525 −64.894 −19.549 −33.112 1.00 33.83 O ATOM 16273 CG2 THR B 525 −64.689 −18.087 −31.227 1.00 33.37 C ATOM 16277 C THR B 525 −67.702 −17.960 −31.184 1.00 34.46 C ATOM 16278 O THR B 525 −67.684 −17.858 −29.955 1.00 34.57 O ATOM 16280 N ARG B 526 −68.401 −17.144 −31.969 1.00 34.54 N ATOM 16281 CA ARG B 526 −69.200 −16.056 −31.418 1.00 34.60 C ATOM 16283 CB ARG B 526 −69.571 −15.059 −32.513 1.00 35.04 C ATOM 16286 CG ARG B 526 −70.256 −13.800 −32.013 1.00 37.13 C ATOM 16289 CD ARG B 526 −70.143 −12.656 −33.026 1.00 39.87 C ATOM 16292 NE ARG B 526 −70.353 −13.075 −34.420 1.00 42.28 N ATOM 16294 CZ ARG B 526 −71.543 −13.292 −35.000 1.00 44.26 C ATOM 16295 NH1 ARG B 526 −72.685 −13.159 −34.320 1.00 44.66 N ATOM 16298 NH2 ARG B 526 −71.593 −13.658 −36.279 1.00 44.49 N ATOM 16301 C ARG B 526 −70.448 −16.593 −30.735 1.00 33.91 C ATOM 16302 O ARG B 526 −70.848 −16.074 −29.704 1.00 33.74 O ATOM 16304 N LYS B 527 −71.048 −17.637 −31.306 1.00 33.39 N ATOM 16305 CA LYS B 527 −72.240 −18.252 −30.722 1.00 33.15 C ATOM 16307 CB LYS B 527 −72.837 −19.332 −31.639 1.00 33.42 C ATOM 16310 CG LYS B 527 −73.898 −18.804 −32.609 1.00 34.55 C ATOM 16313 CD LYS B 527 −74.643 −19.919 −33.358 1.00 35.43 C ATOM 16316 CE LYS B 527 −75.230 −19.383 −34.667 1.00 36.11 C ATOM 16319 NZ LYS B 527 −76.076 −20.372 −35.384 1.00 37.04 N ATOM 16323 C LYS B 527 −71.925 −18.865 −29.378 1.00 32.36 C ATOM 16324 O LYS B 527 −72.589 −18.584 −28.387 1.00 32.56 O ATOM 16326 N ARG B 528 −70.909 −19.713 −29.358 1.00 31.53 N ATOM 16327 CA ARG B 528 −70.502 −20.401 −28.138 1.00 30.77 C ATOM 16329 CB ARG B 528 −69.283 −21.286 −28.414 1.00 30.55 C ATOM 16332 CG ARG B 528 −69.624 −22.519 −29.252 1.00 29.48 C ATOM 16335 CD ARG B 528 −68.418 −23.417 −29.493 1.00 28.05 C ATOM 16338 NE ARG B 528 −68.811 −24.774 −29.880 1.00 26.55 N ATOM 16340 CZ ARG B 528 −67.968 −25.719 −30.288 1.00 25.87 C ATOM 16341 NH1 ARG B 528 −66.668 −25.472 −30.385 1.00 26.33 N ATOM 16344 NH2 ARG B 528 −68.424 −26.920 −30.615 1.00 25.49 N ATOM 16347 C ARG B 528 −70.225 −19.415 −27.004 1.00 30.42 C ATOM 16348 O ARG B 528 −70.721 −19.582 −25.885 1.00 30.30 O ATOM 16350 N VAL B 529 −69.455 −18.376 −27.307 1.00 29.96 N ATOM 16351 CA VAL B 529 −69.194 −17.312 −26.342 1.00 29.47 C ATOM 16353 CB VAL B 529 −68.261 −16.227 −26.932 1.00 29.40 C ATOM 16355 CG1 VAL B 529 −68.269 −14.968 −26.081 1.00 29.18 C ATOM 16359 CG2 VAL B 529 −66.845 −16.782 −27.062 1.00 28.90 C ATOM 16363 C VAL B 529 −70.516 −16.723 −25.841 1.00 28.98 C ATOM 16364 O VAL B 529 −70.759 −16.682 −24.641 1.00 28.97 O ATOM 16366 N LEU B 530 −71.384 −16.308 −26.752 1.00 28.54 N ATOM 16367 CA LEU B 530 −72.709 −15.824 −26.353 1.00 28.23 C ATOM 16369 CB LEU B 530 −73.631 −15.604 −27.559 1.00 28.09 C ATOM 16372 CG LEU B 530 −73.767 −14.150 −28.007 1.00 28.15 C ATOM 16374 CD1 LEU B 530 −72.412 −13.570 −28.406 1.00 27.99 C ATOM 16378 CD2 LEU B 530 −74.784 −14.034 −29.150 1.00 28.85 C ATOM 16382 C LEU B 530 −73.389 −16.767 −25.367 1.00 27.88 C ATOM 16383 O LEU B 530 −73.932 −16.319 −24.363 1.00 28.11 O ATOM 16385 N SER B 531 −73.352 −18.066 −25.652 1.00 27.28 N ATOM 16386 CA SER B 531 −74.081 −19.049 −24.849 1.00 26.68 C ATOM 16388 CB SER B 531 −74.209 −20.363 −25.612 1.00 26.68 C ATOM 16391 OG SER B 531 −72.970 −21.033 −25.681 1.00 26.67 O ATOM 16393 C SER B 531 −73.410 −19.312 −23.514 1.00 26.20 C ATOM 16394 O SER B 531 −74.076 −19.550 −22.511 1.00 25.86 O ATOM 16396 N VAL B 532 −72.085 −19.281 −23.512 1.00 25.86 N ATOM 16397 CA VAL B 532 −71.320 −19.562 −22.306 1.00 25.51 C ATOM 16399 CB VAL B 532 −69.891 −20.055 −22.651 1.00 25.34 C ATOM 16401 CG1 VAL B 532 −68.955 −19.932 −21.460 1.00 24.01 C ATOM 16405 CG2 VAL B 532 −69.950 −21.484 −23.158 1.00 24.95 C ATOM 16409 C VAL B 532 −71.271 −18.357 −21.373 1.00 25.52 C ATOM 16410 O VAL B 532 −71.377 −18.523 −20.164 1.00 25.82 O ATOM 16412 N ILE B 533 −71.137 −17.158 −21.935 1.00 25.39 N ATOM 16413 CA ILE B 533 −70.875 −15.954 −21.151 1.00 25.48 C ATOM 16415 CB ILE B 533 −69.666 −15.185 −21.732 1.00 25.30 C ATOM 16417 CG1 ILE B 533 −68.375 −15.928 −21.451 1.00 24.91 C ATOM 16420 CD1 ILE B 533 −68.118 −16.120 −19.989 1.00 25.00 C ATOM 16424 CG2 ILE B 533 −69.553 −13.797 −21.130 1.00 25.81 C ATOM 16428 C ILE B 533 −72.065 −14.983 −21.030 1.00 25.77 C ATOM 16429 O ILE B 533 −72.537 −14.707 −19.928 1.00 25.77 O ATOM 16431 N THR B 534 −72.541 −14.442 −22.142 1.00 25.98 N ATOM 16432 CA THR B 534 −73.446 −13.295 −22.064 1.00 26.31 C ATOM 16434 CB THR B 534 −73.094 −12.253 −23.143 1.00 26.21 C ATOM 16436 OG1 THR B 534 −72.914 −12.909 −24.397 1.00 26.72 O ATOM 16438 CG2 THR B 534 −71.795 −11.535 −22.781 1.00 25.97 C ATOM 16442 C THR B 534 −74.961 −13.621 −22.064 1.00 26.50 C ATOM 16443 O THR B 534 −75.713 −12.974 −21.344 1.00 26.67 O ATOM 16445 N GLU B 535 −75.410 −14.616 −22.829 1.00 26.55 N ATOM 16446 CA GLU B 535 −76.851 −14.892 −22.961 1.00 26.50 C ATOM 16448 CB GLU B 535 −77.197 −15.197 −24.426 1.00 26.68 C ATOM 16451 CG GLU B 535 −77.226 −13.936 −25.296 1.00 27.68 C ATOM 16454 CD GLU B 535 −78.193 −14.014 −26.475 1.00 28.75 C ATOM 16455 OE1 GLU B 535 −79.370 −13.588 −26.330 1.00 27.72 O ATOM 16456 OE2 GLU B 535 −77.762 −14.492 −27.549 1.00 30.06 O ATOM 16457 C GLU B 535 −77.355 −16.019 −22.056 1.00 26.19 C ATOM 16458 O GLU B 535 −77.021 −17.171 −22.279 1.00 26.15 O ATOM 16460 N PRO B 536 −78.186 −15.697 −21.047 1.00 26.05 N ATOM 16461 CA PRO B 536 −78.692 −16.763 −20.196 1.00 26.05 C ATOM 16463 CB PRO B 536 −79.495 −16.018 −19.118 1.00 25.87 C ATOM 16466 CG PRO B 536 −79.140 −14.621 −19.239 1.00 25.88 C ATOM 16469 CD PRO B 536 −78.760 −14.402 −20.660 1.00 26.21 C ATOM 16472 C PRO B 536 −79.608 −17.717 −20.943 1.00 26.14 C ATOM 16473 O PRO B 536 −80.173 −17.359 −21.973 1.00 25.99 O ATOM 16474 N ILE B 537 −79.746 −18.924 −20.411 1.00 26.38 N ATOM 16475 CA ILE B 537 −80.662 −19.905 −20.960 1.00 26.58 C ATOM 16477 CB ILE B 537 −80.443 −21.292 −20.333 1.00 26.47 C ATOM 16479 CG1 ILE B 537 −79.023 −21.789 −20.600 1.00 26.38 C ATOM 16482 CD1 ILE B 537 −78.709 −23.102 −19.907 1.00 26.40 C ATOM 16486 CG2 ILE B 537 −81.430 −22.300 −20.890 1.00 26.71 C ATOM 16490 C ILE B 537 −82.072 −19.420 −20.657 1.00 26.93 C ATOM 16491 O ILE B 537 −82.347 −18.965 −19.545 1.00 26.81 O ATOM 16493 N LEU B 538 −82.963 −19.491 −21.641 1.00 27.36 N ATOM 16494 CA LEU B 538 −84.309 −18.984 −21.439 1.00 27.68 C ATOM 16496 CB LEU B 538 −85.181 −19.094 −22.698 1.00 27.75 C ATOM 16499 CG LEU B 538 −84.782 −18.291 −23.949 1.00 27.47 C ATOM 16501 CD1 LEU B 538 −85.992 −18.109 −24.844 1.00 27.11 C ATOM 16505 CD2 LEU B 538 −84.164 −16.933 −23.621 1.00 26.99 C ATOM 16509 C LEU B 538 −84.919 −19.752 −20.288 1.00 28.01 C ATOM 16512 N PRO B 539 −85.645 −19.046 −19.421 1.00 28.69 N ATOM 16513 CA PRO B 539 −86.028 −19.631 −18.152 1.00 29.05 C ATOM 16515 CB PRO B 539 −86.640 −18.452 −17.397 1.00 29.08 C ATOM 16518 CG PRO B 539 −87.144 −17.548 −18.447 1.00 28.86 C ATOM 16521 CD PRO B 539 −86.298 −17.748 −19.660 1.00 28.62 C ATOM 16524 C PRO B 539 −87.035 −20.767 −18.259 1.00 29.51 C ATOM 16525 O PRO B 539 −87.665 −20.970 −19.297 1.00 29.23 O ATOM 16526 N PHE B 540 −87.164 −21.500 −17.159 1.00 30.25 N ATOM 16527 CA PHE B 540 −88.089 −22.613 −17.070 1.00 30.56 C ATOM 16529 CB PHE B 540 −87.971 −23.297 −15.708 1.00 30.73 C ATOM 16532 CG PHE B 540 −88.848 −24.499 −15.567 1.00 30.49 C ATOM 16533 CD1 PHE B 540 −89.910 −24.505 −14.683 1.00 30.32 C ATOM 16535 CE1 PHE B 540 −90.718 −25.614 −14.568 1.00 30.59 C ATOM 16537 CZ PHE B 540 −90.475 −26.722 −15.346 1.00 30.55 C ATOM 16539 CE2 PHE B 540 −89.420 −26.720 −16.234 1.00 30.68 C ATOM 16541 CD2 PHE B 540 −88.619 −25.617 −16.342 1.00 30.43 C ATOM 16543 C PHE B 540 −89.507 −22.120 −17.257 1.00 30.76 C ATOM 16544 O PHE B 540 −89.967 −21.257 −16.508 1.00 30.59 O ATOM 16546 N GLU B 541 −90.184 −22.677 −18.259 1.00 31.13 N ATOM 16547 CA GLU B 541 −91.553 −22.289 −18.608 1.00 31.45 C ATOM 16549 CB GLU B 541 −91.525 −21.186 −19.680 1.00 31.60 C ATOM 16552 CG GLU B 541 −92.860 −20.454 −19.911 1.00 32.56 C ATOM 16555 CD GLU B 541 −93.773 −21.133 −20.935 1.00 33.64 C ATOM 16556 OE1 GLU B 541 −93.261 −21.922 −21.771 1.00 35.06 O ATOM 16557 OE2 GLU B 541 −95.002 −20.868 −20.901 1.00 32.44 O ATOM 16558 C GLU B 541 −92.326 −23.510 −19.105 1.00 31.31 C ATOM 16559 O GLU B 541 −92.860 −24.286 −18.310 1.00 31.30 O ATOM 16562 MG MG C 1 −42.844 11.427 13.309 1.00 46.29 MG ATOM 16561 MG MG C 2 −46.615 −18.454 −33.231 1.00 48.45 MG ATOM 16563 O HOH E 1 −50.507 −5.408 −4.491 1.00 17.42 O ATOM 16566 O HOH E 2 −64.748 −36.007 −11.725 1.00 2.00 O ATOM 16569 O HOH E 3 −40.643 −2.220 −34.996 1.00 2.00 O ATOM 16572 O HOH E 4 −36.090 −9.757 −37.074 1.00 17.20 O ATOM 16575 O HOH E 5 −46.117 −37.662 −22.916 1.00 17.03 O ATOM 16578 O HOH E 6 −49.541 35.476 6.921 1.00 14.03 O ATOM 16581 O HOH E 7 −32.288 27.572 16.443 1.00 13.16 O ATOM 16584 O HOH E 8 −50.706 10.207 −15.061 1.00 18.73 O ATOM 16587 O HOH E 9 −77.188 36.767 −9.218 1.00 8.05 O ATOM 16590 O HOH E 10 −90.260 −31.248 −21.071 1.00 2.00 O ATOM 16593 O HOH E 11 −70.920 −33.414 −3.884 1.00 9.35 O ATOM 16596 O HOH E 12 −37.761 −21.294 −9.249 1.00 25.78 O ATOM 16599 O HOH E 13 −76.050 23.855 −18.293 1.00 2.00 O ATOM 16602 O HOH E 14 −76.876 −19.575 −22.856 1.00 19.25 O ATOM 16605 O HOH E 15 −40.936 11.629 −24.832 1.00 22.29 O ATOM 16608 O HOH E 16 −85.551 34.832 3.260 1.00 25.14 O ATOM 16611 O HOH E 17 −56.825 31.771 −7.464 1.00 17.27 O ATOM 16614 O HOH E 18 −76.222 39.261 −.613 1.00 25.47 O

Example 4 Three-Dimensional Structure of P. alba IspS

I. Expression of 6×His-Tagged IspS

N-terminally 6×His-tagged IspS was expressed and purified from strain MD09-167. Construction of MD09-167 is described in Example 2. The growth procedure is suitable for histidine tagged enzymes expressed in BL21(λDE3)pLysS cells. A 10 ml of overnight culture was prepared for each 1 L of planned growth. The appropriate antibiotics (50 mg/ml kanamycin, 50 mg/ml chloramphenicol, and/or 50 mg/ml Carbenecillin) was added to 10 ml of LB medium in a 25 ml flask and was inoculated with 1 colony from a fresh plate of cells or directly from glycerol frozen cell stock. Cultures were grown at 30° C. overnight with shaking at ˜220 rpm. Day cultures were prepared in 1 liter of LB medium with appropriate antibiotics for each culture. Each 1 L day culture was inoculated with 10 ml of overnight culture and grown at 30-37° C. with shaking at ˜220 rpm until the OD₆₀₀ reached ˜0.4-0.6. Day cultures were then induced with 400 μM IPTG and allowed to continue growing at 30° C. with shaking at 220 rpm for ˜5-6 hours. Cells were then harvested by centrifugation at 10,000×g for 10 min, 4° C. Following Harvest, cells were used directly or stored at −80° C. until ready to process

II. Purification of 6×His-Tagged IspS

For purification of histidine tagged enzymes from BL21(λDE3)pLysS cells, cells were gently resuspended in fresh Lysis buffer (Lysis buffer: Ni wash buffer+0.5 mM PMST, 0.01% Tween-20, 1 mg/ml lysozyme, 0.2 mg/ml DNaseI; Ni wash buffer: 50 mM NaH₂PO₄, 300 mM NaCl, 20 mM Imidazole, pH 8.0). Approximately 40-50 ml of lysis buffer was used per 1 L of cell pellet. Cells were then incubated on ice for approximately 30 min. The cell suspension was then lysed fully by passing 2-3 times through a french pressure cell (large french press cell at 1200 psi/High setting) until lysate started to look clear. A sample of the lysate was saved for activity assay and gel analysis (˜100 μl). The lysate was then clarified by centrifuging the lysate at 30,000×g for 30 min, 4° C. in a Sorvall Discovery 90SE ultracentrifuge. The supernatant was removed and retained. A sample of the “clarified lysate” was saved for activity assay and gel analysis (˜100 μl).

The clarified lysate was run over HisTrap HP columns (GE healthcare) using a gradient from 0-100% Ni buffer B. Following loading of the lysate on the column, the column was washed with Ni wash buffer (50 mM NaH₂PO₄, 300 mm NaCl, 20 mM imidazole, ph 8.0). The his-tagged IspS was then eluted from the column using a gradient from 0-100% Ni elution buffer (50 mM NaH₂PO₄, 300 mM NaCl, 500 mM imidazole, ph 8.0) and fractions containing the his-tagged IspS were collected. The column was then washed with Ni stripping buffer (20 mM NaH₂PO₄, 0.5 m NaCl, 50 mM EDTA, ph 7.4). Samples were then analyzed by SDS-PAGE gel (4-12% gel NUPAGE, Invitrogen) according to manufacturer's directions. Desired fractions were concentrated on spin filters (Vivaspin-20, Sartoris,) and then desalted over a Hi Prep 26/10 Desalting column (GE healthcare) packed with Sephadex G25 resin. The G-25 buffer consisted of 50 mM HEPES, 50 mM NaCl, and 1 mM DTT, pH 7.4. The desired sample was then chromatographed on Hi Trap Q HP column (GE) (Q seph buffer A was 50 mM Tris, 0.05 M NaCl, 1 mM DTT, pH 7.6. Q seph buffer B was 50 mM Tris, 1.0 M NaCl, 1 mM DTT, pH 7.6) and concentrated if necessary. Sample buffer was then exchanged by passing sample over a Hi Prep 26/10 Desalting column (GE healthcare) packed with Sephadex G25 resin. A final polishing step of Gel filtration is used as necessary. Pass the sample over a Hi Load 26/60 Superdex 200 prep grade (GE) in gel filtration buffer: (50 mM HEPES, 150 mM NaCl, 1 mM DTT, pH 7.4). Fractions were then analyzed and concentrated. The samples were then stored at −80° C.

TEV Cleavage (IspS from Strains MD09-165 and MD09-167)

For digestion, enzymes were purified through a Ni charged sepharose (GE Healthcare) and desalted into 50 mM HEPES, 50 mM NaCl pH 7.4 buffer containing 1 mM DTT. Digestion was performed with TurboTEV Protease from Eton Bioscience Inc. One unit of TurboTEV per 10 μg of purified protein was used. The digest was performed at 4° C. overnight. Samples were passed through another Ni column equilibrated in the Ni buffer to remove uncleaved enzyme, tag, TurboTEV protease (which is also tagged), and impurities. The Ni column pass though and washes were analyzed using SDS-PAGE gel (NUPAGE, Invitrogen) and DMAPP activity assays. Samples containing pure enzyme were pooled and desalted into 50 mM NaCl pH 7.4 buffer containing 1 mM DTT and stored at −80° C.

III. Crystal Structure Determination

The enzyme expressed from MD09-167 was purified and a concentrated protein solution was then prepared for surveying possible crystallization conditions. The protein was purified independently and surveyed as described below. All in-house crystallization screens were set up using the hanging drop vapor diffusion method. At a minimum, the protein was surveyed using the following commercial screens: the Crystal Screen from Hampton Research (Aliso Viejo, Calif.) and the JCSG+Suite from Qiagen (Valencia, Calif.).

A truncated P. alba IspS construct featuring two additional residues before the twin-arginine motif was generated (MD09-167). This construct contains a C-terminal histidine-tag, and crystallization experiments were set up with the tag either cleaved or not cleaved, at varying protein concentrations, and with or without sodium pyrophosphate. Initial crystallization screens were setup using the Crystal Screen from Hampton Research and the JCSG+Suite from Qiagen. Crystals of protein derived from MD09-167 were observed in numerous conditions; optimization included 528 variations of pH, precipitating agents, concentrations, and inhibitors. From the optimization experiments, twenty different MD09-167 crystals were screened in-house for diffraction. In an effort to improve the resolution, various crystal freezing conditions were tested, with the effect of improving the diffraction limits from 10 Å to 6.5 Å. Upon further optimization of both crystallization and freezing conditions, a crystal composed of non-cleaved histidine-tagged protein was obtained that diffracted to 2.7 Å in house. The large, rod-shaped crystals belong to the tetragonal space group P4₃2₁2, and have unit cell dimensions a=156.8, b=156.8, c=142.5. The crystals were grown by mixing 2 μL of protein (9 mg/ml protein) with 2 μL of precipitant solution (0.2 M NaMalonate, pH 7.0 and 18% (wt/vol) polyethylene glycol 3350) and equilibrated against 500 μL of precipitant. Prior to flash-freezing the crystal in liquid nitrogen, the crystals were cryoprotected by swishing through 0.2 M NaMalonate, pH 7.0, 18% (wt/vol) polyethylene glycol 3350, and 25% (wt/vol) ethylene glycol.

An identical crystal was prepared and sent to Stanford Synchrotron Radiation Laboratory, and data were collected at Beamline 11-1. Data were integrated using Mosflm (Leslie, A. (1998) J. of Appl. Crystallography 30, 1036-1040) and scaled using SCALA (Collaborative Computational Project, N. (1994) Acta Crystallographica Section D 50, 760-763). The data were phased with MOLREP (Vagin, A., and Teplyakov, A. (1997) J. of Appl. Crystallography 30, 1022-1025), using the IspS from P. tremuloides (Example 3) as the starting model. The crystal contains one dimer in the asymmetric unit with a solvent content of 64%. Data collection and refinement statistics are given in Table 4-1.

Refinement with Refmac5 (Collaborative Computational Project, N. (1994) Acta Crystallographica Section D 50, 760-763) was used with iterative manual rebuilding steps using the visualization program Coot (Emsley, P., and Cowtan, K. (2004) Acta Crystallographica Section D 60, 2126-2132). During refinement, the geometry of the protein was checked using Molprobity (Davis, I. W., et al. (2007) Nucl. Acids Res., 35:W375-W383). The coordinates are provided in Table 4-2.

TABLE 4-1 Data Collection and Refinement Statistics Data Collection Space Group P4₃2₁2 Cell dimensions A, b, c (Å) 156.8, 156.8, 142.5 α, β, γ, (°) 90.0, 90.0, 90.0 Resolution (Å) 45.5-2.30 R_(merge)   8.2 (60.6)^(a) <I/σI> 10.0 (2.2)  Completeness (%) 99.1 (96.2) Redundancy 4.7 (4.3) Refinement Resolution (Å) 38.0-2.30 No. measured reflections 366320 No. Unique reflections 74242 R_(work) 20.7 R_(free) 24.2 rmsd bonds, (Å) 0.012 rmsd angles, (°) 1.206 No. of Atoms Protein 8689 Water 205 ^(a)Values in parenthesis refer to highest resolution shell.

TABLE 4-2 Coordinates of P. alba IspS HEADER ----  XX-XXX-9- xxxx COMPND --- REMARK 3 REMARK 3 REFINEMENT. REMARK 3 PROGRAM   : REFMAC 5.5.0088 REMARK 3 AUTHORS  : MURSHUDOV, VAGIN, DODSON REMARK 3 REMARK 3 REFINEMENT TARGET: MAXIMUM LIKELIHOOD REMARK 3 REMARK 3 DATA USED IN REFINEMENT. REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS): 2.30 REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS): 43.66 REMARK 3 DATA CUTOFF (SIGMA(F)): NONE REMARK 3 COMPLETENESS FOR RANGE  (%): 98.90 REMARK 3 NUMBER OF REFLECTIONS  : 74242 REMARK 3 REMARK 3 FIT TO DATA USED IN REFINEMENT. REMARK 3 CROSS-VALIDATION METHOD  : THROUGHOUT REMARK 3 FREE R VALUE TEST SET SELECTION : RANDOM  p REMARK 3 R VALUE (WORKING + TEST SET): 0.20949 REMARK 3 R VALUE (WORKING SET): 0.20777 REMARK 3 FREE R VALUE : 0.24192 REMARK 3 FREE R VALUE TEST SET SIZE (%): 5.1 REMARK 3 FREE R VALUE TEST SET COUNT : 3968 REMARK 3 REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN. REMARK 3 TOTAL NUMBER OF BINS USED  : 20 REMARK 3 BIN RESOLUTION RANGE HIGH  : 2.300 REMARK 3 BIN RESOLUTION RANGE LOW  : 2.360 REMARK 3 REFLECTION IN BIN (WORKING SET): 5205 REMARK 3 BIN COMPLETENESS (WORKING + TEST) (%): 95.11 REMARK 3 BIN R VALUE (WORKING SET): 0.350 REMARK 3 BIN FREE R VALUE SET COUNT : 257 REMARK 3 BIN FREE R VALUE : 0.364 REMARK 3 REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT. REMARK 3 ALL ATOMS  : 8894 REMARK 3 REMARK 3 B VALUES. REMARK 3 FROM WILSON PLOT  (A**2): NULL REMARK 3 MEAN B VALUE (OVERALL, A**2):  28.532 REMARK 3 OVERALL ANISOTROPIC B VALUE. REMARK 3 B11 (A**2):  0.19 REMARK 3 B22 (A**2):  0.19 REMARK 3 B33 (A**2):  −0.39 REMARK 3 B12 (A**2):  −0.00 REMARK 3 B13 (A**2):  −0.00 REMARK 3 B23 (A**2):  0.00 REMARK 3 REMARK 3 ESTIMATED OVERALL COORDINATE ERROR. REMARK 3 ESU BASED ON R VALUE  (A): 0.234 REMARK 3 ESU BASED ON FREE R VALUE  (A): 0.197 REMARK 3 ESU BASED ON MAXIMUM LIKELIHOOD  (A): 0.132 REMARK 3 ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A**2): 12.016 REMARK 3 REMARK 3 CORRELATION COEFFICIENTS. REMARK 3 CORRELATION COEFFICIENT FO-FC  : 0.949 REMARK 3 CORRELATION COEFFICIENT FO-FC FREE: 0.932 REMARK 3 REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES  COUNT  RMS WEIGHT REMARK 3 BOND LENGTHS REFINED ATOMS  (A): 8874 ; 0.012; 0.022 REMARK 3 BOND LENGTHS OTHERS  (A): 6064 ; 0.001 ;0.020 REMARK 3 BOND ANGLES REFINED ATOMS (DEGREES): 12007 ; 1.206 ; 1.952 REMARK 3 BOND ANGLES OTHERS (DEGREES): 14720 ; 0.851 ; 3.000 REMARK 3 TORSION ANGLES, PERIOD 1  (DEGREES): 1070 ; 5.228; 5.000 REMARK 3 TORSION ANGLES, PERIOD 2 (DEGREES): 460 ;35.290 ;24.304 REMARK 3 TORSION ANGLES, PERIOD 3 (DEGREES): 1582 ;14.921 ;15.000 REMARK 3 TORSION ANGLES, PERIOD 4 (DEGREES):  61 ;16.584 ;15.000 REMARK 3 CHIRAL-CENTER RESTRAINTS (A**3):  1314 ; 0.072 ; 0.200 REMARK 3 GENERAL PLANES REFINED ATOMS (A):  9879 ; 0.005 ; 0.020 REMARK 3 GENERAL PLANES OTHERS  (A): 1878 ; 0.001 ;0.020 REMARK 3 REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS.  COUNT RMS WEIGHT REMARK 3 MAIN-CHAIN BOND REFINED ATOMS (A**2): 5310; 1.592; 3.000 REMARK 3 MAIN-CHAIN BOND OTHER ATOMS (A**2): 2148 ; 0.457 ; 3.000 REMARK 3 MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 8546 ; 3.009 ; 5.000 REMARK 3 SIDE-CHAIN BOND REFINED ATOMS (A**2): 3564 ;4.694 ; 8.000 REMARK 3 SIDE-CHAIN ANGLE REFINED ATOMS (A**2): 3455; 7.036 ;11.000 REMARK 3 REMARK 3 NCS RESTRAINTS STATISTICS REMARK 3 NUMBER OF DIFFERENT NCS GROUPS :  1 REMARK 3 REMARK 3 NCS GROUP NUMBER : 1 REMARK 3 CHAIN NAMES : A B REMARK 3 NUMBER OF COMPONENTS NCS GROUP:  1 REMARK 3 COMPONENT C SSSEQI TO C SSSEQI CODE REMARK 3 1 A 1 A 560 4 REMARK 3 1  B  1  B  560  4 REMARK 3  GROUP CHAIN  COUNT RMS WEIGHT REMARK 3 MEDIUM POSITIONAL  1  1  (A): 7275 ; 0.30 ; 0.50 REMARK 3 MEDIUM THERMAL  1  1  (A**2): 7275 ; 0.78 ; 2.00 REMARK 3 REMARK 3 TWIN DETAILS REMARK 3 NUMBER OF TWIN DOMAINS  : NULL REMARK 3 REMARK 3 REMARK 3 TLS DETAILS REMARK 3 NUMBER OF TLS GROUPS : 2 REMARK 3 ATOM RECORD CONTAINS RESIDUAL B FACTORS ONLY REMARK 3 REMARK 3 TLS GROUP :  1 REMARK 3 NUMBER OF COMPONENTS GROUP:  1 REMARK 3 COMPONENTS C SSSEQI TO C SSSEQI REMARK 3 RESIDUE RANGE: A −10  A 9999 REMARK 3 ORIGIN FOR THE GROUP (A): 55.1340 −22.7990 1.5640 REMARK 3 T TENSOR REMARK 3 T11: 0.1012 T22: 0.0842 REMARK 3 T33: 0.0487 T12: −0.0797 REMARK 3 T13: −0.0129 T23: −0.0050 REMARK 3 L TENSOR REMARK 3 L11: 0.4547 L22: 1.7223 REMARK 3 L33: 0.4716 L12: −0.3910 REMARK 3 L13: 0.0096 L23: 0.1512 REMARK 3 S TENSOR REMARK 3 S11: 0.0834 S12: −0.1118 S13: 0.0428 REMARK 3 S21: −0.0018 S22: −0.0458 S23: −0.0748 REMARK 3 S31: −0.0352 S32: 0.0105 S33: −0.0376 REMARK 3 REMARK 3 TLS GROUP : 2 REMARK 3 NUMBER OF COMPONENTS GROUP : 1 REMARK 3 COMPONENTS C SSSEQI TO C SSSEQI REMARK 3 RESIDUE RANGE: B −10  B 9999 REMARK 3 ORIGIN FOR THE GROUP (A): 61.5680 28.1500 −20.5740 REMARK 3 T TENSOR REMARK 3 T11: 0.1284 T22: 0.1262 REMARK 3 T33: 0.1080 T12: 0.0397 REMARK 3 T13: −0.0366 T23: 0.0120 REMARK 3 L TENSOR REMARK 3 L11: 1.1443 L22: 0.6715 REMARK 3 L33: 0.8680 L12: 0.4490 REMARK 3 L13: 0.6089 L23: 0.2346 REMARK 3 S TENSOR REMARK 3 S11: 0.0652 S12: 0.1638 S13: 0.0430 REMARK 3 S21: 0.0628 S22: −0.0956 S23: −0.0492 REMARK 3 S31: −0.0269 S32: 0.2044 S33: 0.0305 REMARK 3 REMARK 3 REMARK 3 BULK SOLVENT MODELLING. REMARK 3 METHOD USED: MASK REMARK 3 PARAMETERS FOR MASK CALCULATION REMARK 3 VDW PROBE RADIUS : 1.40 REMARK 3 ION PROBE RADIUS : 0.80 REMARK 3 SHRINKAGE RADIUS : 0.80 REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: REMARK 3 HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS REMARK 3 U VALUES: RESIDUAL ONLY REMARK 3 REMARK 3 OTHER REFINEMENT REMARKS: 1. RESIDUES A39, A539, A541 ARE REMARK 3 RAMACHANDRAN OUTLIERS AND ARE LOCATED IN POOR DENSITY. LINKR ASN A 512  THR A 517  gap LINKR  SER  B  18  ILE B 24  gap LINKR ASN B 512  THR B 517  gap CRYST1 156.800 156.800 142.480 90.00 90.00 90.00 P 43 21 2 SCALE1 0.006378 0.000000 0.000000 0.00000 SCALE2 −0.000000 0.006378 0.000000 0.00000 SCALE3 0.000000 −0.000000 0.007019 0.00000 ATOM 1 N ALA A 23 59.766 −33.590 −29.936 1.00 64.60 A N ATOM 2 CA ALA A 23 60.006 −32.892 −28.637 1.00 65.14 A C ATOM 4 CB ALA A 23 60.361 −33.912 −27.536 1.00 65.26 A C ATOM 8 C ALA A 23 61.108 −31.833 −28.796 1.00 64.48 A C ATOM 9 O ALA A 23 62.101 −32.081 −29.489 1.00 64.58 A O ATOM 13 N ASN A 24 60.937 −30.692 −28.111 1.00 63.60 A N ATOM 14 CA ASN A 24 61.661 −29.425 −28.393 1.00 63.75 A C ATOM 16 CB ASN A 24 60.620 −28.275 −28.535 1.00 65.26 A C ATOM 19 CG ASN A 24 61.091 −27.095 −29.448 1.00 66.51 A C ATOM 20 OD1 ASN A 24 62.282 −26.926 −29.744 1.00 66.15 A O ATOM 21 ND2 ASN A 24 60.132 −26.265 −29.865 1.00 65.85 A N ATOM 24 C ASN A 24 62.780 −29.018 −27.379 1.00 61.71 A C ATOM 25 O ASN A 24 62.970 −29.635 −26.325 1.00 60.31 A O ATOM 27 N TYR A 25 63.472 −27.935 −27.748 1.00 59.76 A N ATOM 28 CA TYR A 25 64.743 −27.478 −27.188 1.00 57.41 A C ATOM 30 CB TYR A 25 65.795 −27.490 −28.311 1.00 56.05 A C ATOM 33 CG TYR A 25 65.932 −28.808 −29.027 1.00 47.11 A C ATOM 34 CD1 TYR A 25 66.574 −29.878 −28.415 1.00 37.57 A C ATOM 36 CE1 TYR A 25 66.711 −31.092 −29.059 1.00 36.77 A C ATOM 38 CZ TYR A 25 66.203 −31.268 −30.344 1.00 28.44 A C ATOM 39 OH TYR A 25 66.356 −32.509 −30.967 1.00 27.40 A O ATOM 41 CE2 TYR A 25 65.558 −30.217 −30.979 1.00 25.06 A C ATOM 43 CD2 TYR A 25 65.426 −28.988 −30.317 1.00 37.00 A C ATOM 45 C TYR A 25 64.687 −26.036 −26.661 1.00 57.89 A C ATOM 46 O TYR A 25 65.729 −25.384 −26.543 1.00 56.82 A O ATOM 48 N GLU A 26 63.490 −25.529 −26.363 1.00 59.48 A N ATOM 49 CA GLU A 26 63.341 −24.135 −25.907 1.00 60.53 A C ATOM 51 CB GLU A 26 61.868 −23.677 −25.947 1.00 61.98 A C ATOM 54 CG GLU A 26 61.348 −23.344 −27.364 1.00 67.81 A C ATOM 57 CD GLU A 26 61.904 −22.027 −27.939 1.00 76.35 A C ATOM 58 OE1 GLU A 26 61.559 −20.940 −27.414 1.00 79.99 A O ATOM 59 OE2 GLU A 26 62.671 −22.083 −28.931 1.00 78.41 A O ATOM 60 C GLU A 26 63.936 −23.968 −24.504 1.00 57.46 A C ATOM 61 O GLU A 26 63.895 −24.895 −23.710 1.00 55.07 A O ATOM 63 N PRO A 27 64.507 −22.787 −24.210 1.00 56.78 A N ATOM 64 CA PRO A 27 65.154 −22.598 −22.915 1.00 56.84 A C ATOM 66 CB PRO A 27 65.814 −21.217 −23.045 1.00 57.69 A C ATOM 69 CG PRO A 27 65.016 −20.504 −24.075 1.00 58.63 A C ATOM 72 CD PRO A 27 64.502 −21.552 −25.017 1.00 57.02 A C ATOM 75 C PRO A 27 64.169 −22.625 −21.736 1.00 55.20 A C ATOM 76 O PRO A 27 62.977 −22.370 −21.913 1.00 54.56 A O ATOM 77 N ASN A 28 64.673 −22.977 −20.560 1.00 53.26 A N ATOM 78 CA ASN A 28 63.936 −22.792 −19.328 1.00 53.80 A C ATOM 80 CB ASN A 28 64.226 −23.922 −18.345 1.00 55.37 A C ATOM 83 CG ASN A 28 63.955 −25.285 −18.938 1.00 57.15 A C ATOM 84 OD1 ASN A 28 62.803 −25.708 −19.041 1.00 59.44 A O ATOM 85 ND2 ASN A 28 65.019 −25.984 −19.329 1.00 56.57 A N ATOM 88 C ASN A 28 64.302 −21.453 −18.702 1.00 52.53 A C ATOM 89 O ASN A 28 65.445 −20.999 −18.790 1.00 51.17 A O ATOM 91 N SER A 29 63.318 −20.836 −18.057 1.00 52.53 A N ATOM 92 CA SER A 29 63.497 −19.563 −17.340 1.00 52.63 A C ATOM 94 CB SER A 29 62.153 −19.136 −16.735 1.00 53.29 A C ATOM 97 OG SER A 29 61.572 −20.222 −16.014 1.00 52.43 A O ATOM 99 C SER A 29 64.545 −19.616 −16.215 1.00 51.47 A C ATOM 100 O SER A 29 64.999 −18.576 −15.746 1.00 51.59 A O ATOM 102 N TRP A 30 64.891 −20.826 −15.774 1.00 50.43 A N ATOM 103 CA TRP A 30 65.901 −21.041 −14.731 1.00 50.20 A C ATOM 105 CB TRP A 30 65.343 −21.978 −13.637 1.00 50.36 A C ATOM 108 CG TRP A 30 64.573 −23.177 −14.155 1.00 51.86 A C ATOM 109 CD1 TRP A 30 63.214 −23.313 −14.211 1.00 56.08 A C ATOM 111 NE1 TRP A 30 62.880 −24.533 −14.750 1.00 60.74 A N ATOM 113 CE2 TRP A 30 64.029 −25.215 −15.051 1.00 54.80 A C ATOM 114 CD2 TRP A 30 65.119 −24.392 −14.688 1.00 51.20 A C ATOM 115 CE3 TRP A 30 66.419 −24.862 −14.894 1.00 57.41 A C ATOM 117 CZ3 TRP A 30 66.591 −26.131 −15.460 1.00 60.80 A C ATOM 119 CH2 TRP A 30 65.483 −26.925 −15.807 1.00 61.30 A C ATOM 121 CZ2 TRP A 30 64.199 −26.484 −15.611 1.00 60.79 A C ATOM 123 C TRP A 30 67.266 −21.562 −15.250 1.00 49.62 A C ATOM 124 O TRP A 30 68.187 −21.761 −14.454 1.00 48.73 A O ATOM 126 N ASP A 31 67.411 −21.778 −16.561 1.00 49.12 A N ATOM 127 CA ASP A 31 68.692 −22.273 −17.113 1.00 48.38 A C ATOM 129 CB ASP A 31 68.649 −22.407 −18.638 1.00 48.56 A C ATOM 132 CG ASP A 31 67.723 −23.505 −19.108 1.00 47.65 A C ATOM 133 OD1 ASP A 31 67.602 −24.547 −18.429 1.00 50.40 A O ATOM 134 OD2 ASP A 31 67.117 −23.313 −20.175 1.00 49.25 A O ATOM 135 C ASP A 31 69.801 −21.307 −16.760 1.00 47.85 A C ATOM 136 O ASP A 31 69.563 −20.102 −16.691 1.00 47.37 A O ATOM 138 N TYR A 32 71.010 −21.821 −16.546 1.00 46.83 A N ATOM 139 CA TYR A 32 72.126 −20.945 −16.201 1.00 47.06 A C ATOM 141 CB TYR A 32 73.335 −21.742 −15.707 1.00 44.99 A C ATOM 144 CG TYR A 32 73.105 −22.461 −14.388 1.00 41.43 A C ATOM 145 CD1 TYR A 32 72.786 −21.755 −13.213 1.00 36.43 A C ATOM 147 CE1 TYR A 32 72.587 −22.428 −12.008 1.00 26.59 A C ATOM 149 CZ TYR A 32 72.708 −23.786 −11.980 1.00 28.34 A C ATOM 150 OH TYR A 32 72.521 −24.456 −10.829 1.00 27.28 A O ATOM 152 CE2 TYR A 32 73.043 −24.506 −13.113 1.00 33.62 A C ATOM 154 CD2 TYR A 32 73.241 −23.843 −14.302 1.00 36.99 A C ATOM 156 C TYR A 32 72.520 −19.999 −17.343 1.00 49.23 A C ATOM 157 O TYR A 32 73.087 −18.945 −17.081 1.00 46.64 A O ATOM 159 N ASP A 33 72.229 −20.380 −18.591 1.00 53.18 A N ATOM 160 CA ASP A 33 72.441 −19.503 −19.758 1.00 56.33 A C ATOM 162 CB ASP A 33 72.191 −20.264 −21.080 1.00 56.22 A C ATOM 165 CG ASP A 33 73.311 −21.266 −21.435 1.00 55.52 A C ATOM 166 OD1 ASP A 33 74.495 −21.027 −21.103 1.00 50.09 A O ATOM 167 OD2 ASP A 33 73.004 −22.293 −22.087 1.00 54.49 A O ATOM 168 C ASP A 33 71.539 −18.250 −19.701 1.00 60.14 A C ATOM 169 O ASP A 33 71.973 −17.150 −20.064 1.00 59.09 A O ATOM 171 N TYR A 34 70.298 −18.429 −19.241 1.00 64.30 A N ATOM 172 CA TYR A 34 69.300 −17.346 −19.158 1.00 68.93 A C ATOM 174 CB TYR A 34 67.880 −17.942 −19.169 1.00 69.88 A C ATOM 177 CG TYR A 34 66.754 −16.929 −19.206 1.00 79.07 A C ATOM 178 CD1 TYR A 34 66.346 −16.345 −20.411 1.00 87.57 A C ATOM 180 CE1 TYR A 34 65.300 −15.405 −20.444 1.00 90.15 A C ATOM 182 CZ TYR A 34 64.653 −15.057 −19.261 1.00 92.74 A C ATOM 183 OH TYR A 34 63.620 −14.141 −19.270 1.00 95.62 A O ATOM 185 CE2 TYR A 34 65.041 −15.631 −18.056 1.00 89.91 A C ATOM 187 CD2 TYR A 34 66.084 −16.561 −18.034 1.00 85.72 A C ATOM 189 C TYR A 34 69.529 −16.449 −17.926 1.00 70.23 A C ATOM 190 O TYR A 34 69.797 −15.260 −18.063 1.00 70.32 A O ATOM 192 N LEU A 35 69.427 −17.020 −16.727 1.00 73.06 A N ATOM 193 CA LEU A 35 69.867 −16.341 −15.501 1.00 75.25 A C ATOM 195 CB LEU A 35 69.506 −17.156 −14.250 1.00 74.64 A C ATOM 198 CG LEU A 35 68.069 −17.615 −13.995 1.00 71.74 A C ATOM 200 CD1 LEU A 35 68.046 −18.584 −12.822 1.00 67.99 A C ATOM 204 CD2 LEU A 35 67.150 −16.432 −13.741 1.00 67.75 A C ATOM 208 C LEU A 35 71.379 −16.252 −15.592 1.00 78.42 A C ATOM 209 O LEU A 35 71.962 −16.873 −16.472 1.00 80.06 A O ATOM 211 N LEU A 36 72.028 −15.505 −14.705 1.00 81.43 A N ATOM 212 CA LEU A 36 73.494 −15.583 −14.598 1.00 84.46 A C ATOM 214 CB LEU A 36 73.881 −16.978 −14.068 1.00 84.18 A C ATOM 217 CG LEU A 36 75.259 −17.216 −13.442 1.00 84.76 A C ATOM 219 CD1 LEU A 36 75.421 −16.414 −12.157 1.00 87.18 A C ATOM 223 CD2 LEU A 36 75.470 −18.700 −13.189 1.00 83.02 A C ATOM 227 C LEU A 36 74.237 −15.311 −15.928 1.00 86.75 A C ATOM 228 O LEU A 36 75.330 −15.834 −16.156 1.00 86.15 A O ATOM 230 N SER A 37 73.644 −14.503 −16.805 1.00 90.20 A N ATOM 231 CA SER A 37 74.279 −14.168 −18.080 1.00 92.56 A C ATOM 233 CB SER A 37 73.237 −14.010 −19.189 1.00 92.69 A C ATOM 236 OG SER A 37 73.808 −14.292 −20.454 1.00 92.23 A O ATOM 238 C SER A 37 75.107 −12.893 −17.907 1.00 94.60 A C ATOM 239 O SER A 37 74.881 −12.121 −16.964 1.00 94.48 A O ATOM 241 N SER A 38 76.056 −12.684 −18.822 1.00 96.76 A N ATOM 242 CA SER A 38 77.120 −11.683 −18.643 1.00 98.37 A C ATOM 244 CB SER A 38 78.236 −11.866 −19.687 1.00 98.25 A C ATOM 247 OG SER A 38 77.731 −11.924 −21.008 1.00 97.84 A O ATOM 249 C SER A 38 76.642 −10.232 −18.666 1.00 99.95 A C ATOM 250 O SER A 38 76.185 −9.731 −19.698 1.00 100.18 A O ATOM 252 N ASP A 39 76.771 −9.569 −17.517 1.00 101.78 A N ATOM 253 CA ASP A 39 76.622 −8.115 −17.417 1.00 103.16 A C ATOM 255 CB ASP A 39 76.312 −7.727 −15.956 1.00 103.31 A C ATOM 258 CG ASP A 39 75.475 −6.452 −15.835 1.00 103.40 A C ATOM 259 OD1 ASP A 39 75.487 −5.615 −16.765 1.00 100.38 A O ATOM 260 OD2 ASP A 39 74.804 −6.290 −14.792 1.00 103.82 A O ATOM 261 C ASP A 39 77.945 −7.505 −17.942 1.00 104.15 A C ATOM 262 O ASP A 39 78.518 −8.032 −18.904 1.00 104.67 A O ATOM 264 N THR A 40 78.436 −6.414 −17.343 1.00 104.86 A N ATOM 265 CA THR A 40 79.818 −5.955 −17.599 1.00 105.03 A C ATOM 267 CB THR A 40 79.942 −4.397 −17.544 1.00 105.17 A C ATOM 269 OG1 THR A 40 78.774 −3.789 −18.111 1.00 104.08 A O ATOM 271 CG2 THR A 40 81.187 −3.917 −18.306 1.00 103.97 A C ATOM 275 C THR A 40 80.802 −6.605 −16.594 1.00 105.16 A C ATOM 276 O THR A 40 81.804 −5.992 −16.206 1.00 105.14 A O ATOM 278 N ASP A 41 80.509 −7.851 −16.198 1.00 104.87 A N ATOM 279 CA ASP A 41 81.285 −8.600 −15.198 1.00 104.03 A C ATOM 281 CB ASP A 41 80.400 −8.951 −13.991 1.00 103.68 A C ATOM 284 CG ASP A 41 80.063 −7.737 −13.126 1.00 103.58 A C ATOM 285 OD1 ASP A 41 80.402 −6.594 −13.506 1.00 101.01 A O ATOM 286 OD2 ASP A 41 79.455 −7.929 −12.053 1.00 103.04 A O ATOM 287 C ASP A 41 81.884 −9.883 −15.807 1.00 103.35 A C ATOM 288 O ASP A 41 81.159 −10.738 −16.329 1.00 102.89 A O ATOM 290 N GLU A 42 83.210 −10.005 −15.715 1.00 102.70 A N ATOM 291 CA GLU A 42 83.965 −11.067 −16.392 1.00 102.05 A C ATOM 293 CB GLU A 42 85.477 −10.775 −16.342 1.00 101.98 A C ATOM 296 CG GLU A 42 85.924 −9.517 −17.102 1.00 101.14 A C ATOM 299 CD GLU A 42 87.445 −9.357 −17.170 1.00 99.92 A C ATOM 300 OE1 GLU A 42 88.174 −10.198 −16.603 1.00 99.06 A O ATOM 301 OE2 GLU A 42 87.916 −8.384 −17.797 1.00 96.85 A O ATOM 302 C GLU A 42 83.700 −12.466 −15.820 1.00 101.77 A C ATOM 303 O GLU A 42 83.463 −13.410 −16.582 1.00 102.06 A O ATOM 305 N SER A 43 83.748 −12.599 −14.491 1.00 100.69 A N ATOM 306 CA SER A 43 83.632 −13.915 −13.829 1.00 99.39 A C ATOM 308 CB SER A 43 84.695 −14.072 −12.721 1.00 99.42 A C ATOM 311 OG SER A 43 84.503 −13.160 −11.657 1.00 98.04 A O ATOM 313 C SER A 43 82.213 −14.252 −13.308 1.00 97.81 A C ATOM 314 O SER A 43 82.054 −15.108 −12.424 1.00 96.95 A O ATOM 316 N ILE A 44 81.195 −13.579 −13.859 1.00 95.85 A N ATOM 317 CA ILE A 44 79.816 −14.092 −13.827 1.00 94.49 A C ATOM 319 CB ILE A 44 78.734 −12.989 −14.132 1.00 94.92 A C ATOM 321 CG1 ILE A 44 78.344 −12.217 −12.858 1.00 95.86 A C ATOM 324 CD1 ILE A 44 77.084 −11.338 −13.006 1.00 93.80 A C ATOM 328 CG2 ILE A 44 77.467 −13.603 −14.731 1.00 94.41 A C ATOM 332 C ILE A 44 79.704 −15.251 −14.832 1.00 92.51 A C ATOM 333 O ILE A 44 78.815 −16.099 −14.698 1.00 91.97 A O ATOM 335 N GLU A 45 80.615 −15.284 −15.817 1.00 90.17 A N ATOM 336 CA GLU A 45 80.662 −16.342 −16.845 1.00 88.08 A C ATOM 338 CB GLU A 45 81.071 −15.768 −18.205 1.00 88.74 A C ATOM 341 CG GLU A 45 79.979 −14.922 −18.864 1.00 91.64 A C ATOM 344 CD GLU A 45 79.561 −15.416 −20.250 1.00 94.30 A C ATOM 345 OE1 GLU A 45 80.265 −16.268 −20.839 1.00 95.27 A O ATOM 346 OE2 GLU A 45 78.513 −14.946 −20.746 1.00 92.80 A O ATOM 347 C GLU A 45 81.570 −17.536 −16.521 1.00 85.08 A C ATOM 348 O GLU A 45 81.331 −18.638 −17.021 1.00 84.95 A O ATOM 350 N VAL A 46 82.620 −17.323 −15.727 1.00 81.35 A N ATOM 351 CA VAL A 46 83.420 −18.442 −15.202 1.00 78.09 A C ATOM 353 CB VAL A 46 84.741 −17.959 −14.548 1.00 78.08 A C ATOM 355 CG1 VAL A 46 85.516 −19.136 −13.944 1.00 78.15 A C ATOM 359 CG2 VAL A 46 85.603 −17.213 −15.570 1.00 79.62 A C ATOM 363 C VAL A 46 82.583 −19.247 −14.187 1.00 74.06 A C ATOM 364 O VAL A 46 82.718 −20.472 −14.090 1.00 73.88 A O ATOM 366 N TYR A 47 81.728 −18.528 −13.451 1.00 68.93 A N ATOM 367 CA TYR A 47 80.741 −19.086 −12.512 1.00 65.54 A C ATOM 369 CB TYR A 47 80.142 −17.905 −11.718 1.00 65.84 A C ATOM 372 CG TYR A 47 79.247 −18.192 −10.516 1.00 68.89 A C ATOM 373 CD1 TYR A 47 79.776 −18.352 −9.229 1.00 72.76 A C ATOM 375 CE1 TYR A 47 78.930 −18.585 −8.113 1.00 72.95 A C ATOM 377 CZ TYR A 47 77.542 −18.631 −8.291 1.00 72.91 A C ATOM 378 OH TYR A 47 76.679 −18.853 −7.222 1.00 53.89 A O ATOM 380 CE2 TYR A 47 77.008 −18.448 −9.560 1.00 71.64 A C ATOM 382 CD2 TYR A 47 77.859 −18.216 −10.655 1.00 72.02 A C ATOM 384 C TYR A 47 79.658 −19.899 −13.280 1.00 61.30 A C ATOM 385 O TYR A 47 79.353 −21.044 −12.929 1.00 59.34 A O ATOM 387 N LYS A 48 79.109 −19.287 −14.333 1.00 56.43 A N ATOM 388 CA LYS A 48 78.171 −19.918 −15.284 1.00 52.55 A C ATOM 390 CB LYS A 48 77.920 −18.945 −16.451 1.00 53.28 A C ATOM 393 CG LYS A 48 76.989 −19.391 −17.592 1.00 55.50 A C ATOM 396 CD LYS A 48 77.428 −18.712 −18.913 1.00 61.02 A C ATOM 399 CE LYS A 48 76.323 −18.612 −19.970 1.00 65.42 A C ATOM 402 NZ LYS A 48 75.608 −17.279 −19.985 1.00 66.42 A N ATOM 406 C LYS A 48 78.673 −21.255 −15.828 1.00 47.94 A C ATOM 407 O LYS A 48 78.023 −22.273 −15.643 1.00 47.33 A O ATOM 409 N ASP A 49 79.822 −21.250 −16.496 1.00 44.41 A N ATOM 410 CA ASP A 49 80.382 −22.471 −17.087 1.00 43.52 A C ATOM 412 CB ASP A 49 81.659 −22.188 −17.915 1.00 44.86 A C ATOM 415 CG ASP A 49 81.387 −21.342 −19.179 1.00 48.93 A C ATOM 416 OD1 ASP A 49 80.230 −21.330 −19.679 1.00 53.55 A O ATOM 417 OD2 ASP A 49 82.339 −20.689 −19.670 1.00 47.52 A O ATOM 418 C ASP A 49 80.680 −23.512 −16.011 1.00 41.34 A C ATOM 419 O ASP A 49 80.564 −24.715 −16.263 1.00 39.75 A O ATOM 421 N LYS A 50 81.052 −23.055 −14.813 1.00 39.19 A N ATOM 422 CA LYS A 50 81.252 −23.967 −13.693 1.00 37.19 A C ATOM 424 CB LYS A 50 81.870 −23.260 −12.480 1.00 39.17 A C ATOM 427 CG LYS A 50 82.291 −24.204 −11.330 1.00 44.35 A C ATOM 430 CD LYS A 50 82.896 −23.401 −10.166 1.00 55.34 A C ATOM 433 CE LYS A 50 84.411 −23.260 −10.273 1.00 59.44 A C ATOM 436 NZ LYS A 50 84.866 −21.942 −9.757 1.00 57.35 A N ATOM 440 C LYS A 50 79.920 −24.617 −13.344 1.00 33.13 A C ATOM 441 O LYS A 50 79.846 −25.845 −13.254 1.00 31.70 A O ATOM 443 N ALA A 51 78.862 −23.813 −13.195 1.00 28.95 A N ATOM 444 CA ALA A 51 77.540 −24.361 −12.872 1.00 27.76 A C ATOM 446 CB ALA A 51 76.523 −23.233 −12.640 1.00 27.51 A C ATOM 450 C ALA A 51 77.030 −25.359 −13.942 1.00 26.48 A C ATOM 451 O ALA A 51 76.596 −26.462 −13.615 1.00 28.45 A O ATOM 453 N LYS A 52 77.104 −24.980 −15.212 1.00 25.84 A N ATOM 454 CA LYS A 52 76.704 −25.867 −16.319 1.00 25.55 A C ATOM 456 CB LYS A 52 77.062 −25.228 −17.679 1.00 25.87 A C ATOM 459 CG LYS A 52 76.061 −24.158 −18.106 1.00 30.35 A C ATOM 462 CD LYS A 52 76.635 −23.079 −19.007 1.00 29.72 A C ATOM 465 CE LYS A 52 76.636 −23.486 −20.493 1.00 39.59 A C ATOM 468 NZ LYS A 52 77.217 −22.424 −21.416 1.00 37.70 A N ATOM 472 C LYS A 52 77.345 −27.247 −16.217 1.00 25.06 A C ATOM 473 O LYS A 52 76.678 −28.266 −16.388 1.00 24.13 A O ATOM 475 N LYS A 53 78.647 −27.270 −15.941 1.00 25.32 A N ATOM 476 CA LYS A 53 79.407 −28.529 −15.862 1.00 26.67 A C ATOM 478 CB LYS A 53 80.915 −28.230 −15.729 1.00 28.91 A C ATOM 481 CG LYS A 53 81.781 −29.479 −15.584 1.00 38.89 A C ATOM 484 CD LYS A 53 83.274 −29.214 −15.866 1.00 51.52 A C ATOM 487 CE LYS A 53 84.101 −30.510 −15.696 1.00 55.41 A C ATOM 490 NZ LYS A 53 85.467 −30.399 −16.280 1.00 56.50 A N ATOM 494 C LYS A 53 78.940 −29.439 −14.705 1.00 23.90 A C ATOM 495 O LYS A 53 78.751 −30.648 −14.893 1.00 21.50 A O ATOM 497 N LEU A 54 78.770 −28.847 −13.523 1.00 20.73 A N ATOM 498 CA LEU A 54 78.317 −29.568 −12.343 1.00 21.72 A C ATOM 500 CB LEU A 54 78.280 −28.637 −11.120 1.00 21.06 A C ATOM 503 CG LEU A 54 79.601 −27.919 −10.778 1.00 26.70 A C ATOM 505 CD1 LEU A 54 79.389 −26.832 −9.753 1.00 21.18 A C ATOM 509 CD2 LEU A 54 80.674 −28.909 −10.299 1.00 27.08 A C ATOM 513 C LEU A 54 76.927 −30.132 −12.611 1.00 21.21 A C ATOM 514 O LEU A 54 76.642 −31.304 −12.353 1.00 21.09 A O ATOM 516 N GLU A 55 76.073 −29.270 −13.144 1.00 21.62 A N ATOM 517 CA GLU A 55 74.692 −29.602 −13.409 1.00 20.09 A C ATOM 519 CB GLU A 55 73.961 −28.375 −13.955 1.00 20.04 A C ATOM 522 CG GLU A 55 72.497 −28.639 −14.395 1.00 25.33 A C ATOM 525 CD GLU A 55 71.880 −27.437 −15.100 1.00 25.76 A C ATOM 526 OE1 GLU A 55 72.558 −26.836 −15.953 1.00 27.45 A O ATOM 527 OE2 GLU A 55 70.731 −27.095 −14.790 1.00 28.92 A O ATOM 528 C GLU A 55 74.614 −30.736 −14.410 1.00 19.08 A C ATOM 529 O GLU A 55 73.764 −31.614 −14.286 1.00 17.95 A O ATOM 531 N ALA A 56 75.505 −30.721 −15.396 1.00 18.58 A N ATOM 532 CA ALA A 56 75.516 −31.770 −16.419 1.00 18.68 A C ATOM 534 CB ALA A 56 76.589 −31.476 −17.477 1.00 17.67 A C ATOM 538 C ALA A 56 75.782 −33.105 −15.784 1.00 18.70 A C ATOM 539 O ALA A 56 75.164 −34.107 −16.140 1.00 21.50 A O ATOM 541 N GLU A 57 76.717 −33.118 −14.840 1.00 19.66 A N ATOM 542 CA GLU A 57 77.138 −34.352 −14.191 1.00 19.60 A C ATOM 544 CB GLU A 57 78.451 −34.147 −13.404 1.00 21.64 A C ATOM 547 CG GLU A 57 78.990 −35.425 −12.709 1.00 27.13 A C ATOM 550 CD GLU A 57 80.415 −35.275 −12.139 1.00 28.89 A C ATOM 551 OE1 GLU A 57 81.165 −34.363 −12.546 1.00 30.32 A O ATOM 552 OE2 GLU A 57 80.781 −36.104 −11.276 1.00 36.69 A O ATOM 553 C GLU A 57 76.009 −34.867 −13.316 1.00 18.61 A C ATOM 554 O GLU A 57 75.731 −36.037 −13.348 1.00 19.99 A O ATOM 556 N VAL A 58 75.313 −33.996 −12.580 1.00 19.50 A N ATOM 557 CA VAL A 58 74.171 −34.452 −11.772 1.00 18.20 A C ATOM 559 CB VAL A 58 73.603 −33.329 −10.893 1.00 21.45 A C ATOM 561 CG1 VAL A 58 72.374 −33.841 −10.141 1.00 16.09 A C ATOM 565 CG2 VAL A 58 74.659 −32.800 −9.918 1.00 17.59 A C ATOM 569 C VAL A 58 73.062 −35.007 −12.676 1.00 18.18 A C ATOM 570 O VAL A 58 72.461 −36.063 −12.402 1.00 17.53 A O ATOM 572 N ARG A 59 72.841 −34.337 −13.802 1.00 20.36 A N ATOM 573 CA ARG A 59 71.896 −34.833 −14.819 1.00 19.83 A C ATOM 575 CB ARG A 59 71.891 −33.923 −16.049 1.00 20.72 A C ATOM 578 CG ARG A 59 70.959 −34.357 −17.180 1.00 21.44 A C ATOM 581 CD ARG A 59 71.656 −35.311 −18.172 1.00 26.88 A C ATOM 584 NE ARG A 59 70.756 −35.765 −19.235 1.00 26.75 A N ATOM 586 CZ ARG A 59 70.980 −36.808 −20.035 1.00 27.29 A C ATOM 587 NH1 ARG A 59 70.079 −37.128 −20.948 1.00 26.52 A N ATOM 590 NH2 ARG A 59 72.106 −37.527 −19.954 1.00 26.33 A N ATOM 593 C ARG A 59 72.271 −36.239 −15.210 1.00 20.53 A C ATOM 594 O ARG A 59 71.435 −37.137 −15.233 1.00 21.41 A O ATOM 596 N ARG A 60 73.546 −36.445 −15.495 1.00 21.14 A N ATOM 597 CA ARG A 60 73.988 −37.755 −15.936 1.00 19.56 A C ATOM 599 CB ARG A 60 75.477 −37.765 −16.209 1.00 19.04 A C ATOM 602 CG ARG A 60 75.986 −39.109 −16.690 1.00 21.95 A C ATOM 605 CD ARG A 60 77.465 −39.067 −16.905 1.00 21.61 A C ATOM 608 NE ARG A 60 78.162 −38.960 −15.637 1.00 25.86 A N ATOM 610 CZ ARG A 60 79.450 −38.659 −15.502 1.00 27.72 A C ATOM 611 NH1 ARG A 60 79.957 −38.595 −14.288 1.00 27.66 A N ATOM 614 NH2 ARG A 60 80.239 −38.429 −16.561 1.00 24.85 A N ATOM 617 C ARG A 60 73.680 −38.834 −14.910 1.00 20.09 A C ATOM 618 O ARG A 60 73.184 −39.907 −15.260 1.00 19.04 A O ATOM 620 N GLU A 61 73.987 −38.556 −13.652 1.00 21.36 A N ATOM 621 CA GLU A 61 73.834 −39.565 −12.586 1.00 21.08 A C ATOM 623 CB GLU A 61 74.503 −39.095 −11.291 1.00 20.78 A C ATOM 626 CG GLU A 61 76.019 −38.914 −11.424 1.00 29.32 A C ATOM 629 CD GLU A 61 76.700 −40.205 −11.825 1.00 33.44 A C ATOM 630 OE1 GLU A 61 76.614 −41.174 −11.038 1.00 32.69 A O ATOM 631 OE2 GLU A 61 77.297 −40.251 −12.930 1.00 36.93 A O ATOM 632 C GLU A 61 72.376 −39.954 −12.308 1.00 19.59 A C ATOM 633 O GLU A 61 72.124 −41.076 −11.938 1.00 21.54 A O ATOM 635 N ILE A 62 71.443 −39.024 −12.485 1.00 20.46 A N ATOM 636 CA ILE A 62 70.019 −39.298 −12.290 1.00 20.63 A C ATOM 638 CB ILE A 62 69.195 −38.010 −12.148 1.00 20.75 A C ATOM 640 CG1 ILE A 62 69.651 −37.184 −10.937 1.00 20.34 A C ATOM 643 CD1 ILE A 62 69.052 −35.781 −10.885 1.00 17.82 A C ATOM 647 CG2 ILE A 62 67.708 −38.363 −12.000 1.00 21.70 A C ATOM 651 C ILE A 62 69.462 −40.108 −13.462 1.00 22.58 A C ATOM 652 O ILE A 62 68.548 −40.895 −13.298 1.00 23.12 A O ATOM 654 N ASN A 63 70.008 −39.899 −14.656 1.00 24.14 A N ATOM 655 CA ASN A 63 69.567 −40.628 −15.840 1.00 22.08 A C ATOM 657 CB ASN A 63 69.839 −39.776 −17.071 1.00 20.09 A C ATOM 660 CG ASN A 63 68.812 −38.693 −17.256 1.00 24.05 A C ATOM 661 OD1 ASN A 63 67.809 −38.925 −17.893 1.00 28.24 A O ATOM 662 ND2 ASN A 63 69.063 −37.493 −16.717 1.00 22.91 A N ATOM 665 C ASN A 63 70.232 −41.999 −15.980 1.00 23.43 A C ATOM 666 O ASN A 63 69.809 −42.829 −16.783 1.00 25.36 A O ATOM 668 N ASN A 64 71.277 −42.226 −15.194 1.00 25.57 A N ATOM 669 CA ASN A 64 72.064 −43.451 −15.242 1.00 27.94 A C ATOM 671 CB ASN A 64 73.151 −43.357 −14.165 1.00 27.54 A C ATOM 674 CG ASN A 64 74.104 −44.557 −14.138 1.00 30.25 A C ATOM 675 OD1 ASN A 64 74.164 −45.350 −15.074 1.00 24.98 A O ATOM 676 ND2 ASN A 64 74.876 −44.666 −13.054 1.00 20.45 A N ATOM 679 C ASN A 64 71.185 −44.656 −14.992 1.00 30.41 A C ATOM 680 O ASN A 64 70.691 −44.821 −13.892 1.00 32.21 A O ATOM 682 N GLU A 65 71.004 −45.516 −15.989 1.00 33.50 A N ATOM 683 CA GLU A 65 70.150 −46.701 −15.800 1.00 35.73 A C ATOM 685 CB GLU A 65 69.578 −47.175 −17.129 1.00 36.73 A C ATOM 688 CG GLU A 65 68.675 −46.102 −17.762 1.00 41.17 A C ATOM 691 CD GLU A 65 67.803 −46.596 −18.908 1.00 48.22 A C ATOM 692 OE1 GLU A 65 67.712 −47.831 −19.150 1.00 47.55 A O ATOM 693 OE2 GLU A 65 67.194 −45.716 −19.562 1.00 48.75 A O ATOM 694 C GLU A 65 70.871 −47.836 −15.094 1.00 36.68 A C ATOM 695 O GLU A 65 70.240 −48.776 −14.634 1.00 37.20 A O ATOM 697 N LYS A 66 72.189 −47.730 −14.984 1.00 36.43 A N ATOM 698 CA LYS A 66 72.999 −48.790 −14.404 1.00 37.11 A C ATOM 700 CB LYS A 66 74.383 −48.828 −15.084 1.00 38.18 A C ATOM 703 CG LYS A 66 74.340 −48.999 −16.621 1.00 41.19 A C ATOM 706 CD LYS A 66 75.757 −48.982 −17.252 1.00 47.45 A C ATOM 709 CE LYS A 66 75.731 −49.109 −18.801 1.00 47.41 A C ATOM 712 NZ LYS A 66 74.829 −50.210 −19.287 1.00 47.24 A N ATOM 716 C LYS A 66 73.166 −48.635 −12.890 1.00 35.98 A C ATOM 717 O LYS A 66 73.803 −49.470 −12.252 1.00 36.59 A O ATOM 719 N ALA A 67 72.594 −47.585 −12.309 1.00 35.32 A N ATOM 720 CA ALA A 67 72.761 −47.334 −10.869 1.00 35.29 A C ATOM 722 CB ALA A 67 72.338 −45.929 −10.522 1.00 34.33 A C ATOM 726 C ALA A 67 71.970 −48.331 −10.027 1.00 35.67 A C ATOM 727 O ALA A 67 70.907 −48.823 −10.436 1.00 34.29 A O ATOM 729 N GLU A 68 72.502 −48.627 −8.850 1.00 36.18 A N ATOM 730 CA GLU A 68 71.759 −49.403 −7.869 1.00 38.84 A C ATOM 732 CB GLU A 68 72.619 −49.725 −6.645 1.00 40.31 A C ATOM 735 CG GLU A 68 72.545 −51.178 −6.224 1.00 51.58 A C ATOM 738 CD GLU A 68 73.198 −52.108 −7.240 1.00 62.21 A C ATOM 739 OE1 GLU A 68 74.352 −51.827 −7.646 1.00 67.12 A O ATOM 740 OE2 GLU A 68 72.558 −53.114 −7.632 1.00 64.39 A O ATOM 741 C GLU A 68 70.558 −48.554 −7.476 1.00 38.64 A C ATOM 742 O GLU A 68 70.672 −47.332 −7.342 1.00 37.36 A O ATOM 744 N PHE A 69 69.407 −49.194 −7.315 1.00 39.25 A N ATOM 745 CA PHE A 69 68.163 −48.453 −7.180 1.00 41.61 A C ATOM 747 CB PHE A 69 66.925 −49.361 −7.351 1.00 43.96 A C ATOM 750 CG PHE A 69 66.460 −49.487 −8.795 1.00 54.44 A C ATOM 751 CD1 PHE A 69 66.310 −48.336 −9.610 1.00 61.05 A C ATOM 753 CE1 PHE A 69 65.882 −48.429 −10.943 1.00 61.96 A C ATOM 755 CZ PHE A 69 65.586 −49.684 −11.483 1.00 65.52 A C ATOM 757 CE2 PHE A 69 65.728 −50.846 −10.681 1.00 65.07 A C ATOM 759 CD2 PHE A 69 66.161 −50.739 −9.344 1.00 62.25 A C ATOM 761 C PHE A 69 68.094 −47.639 −5.889 1.00 39.35 A C ATOM 762 O PHE A 69 67.620 −46.506 −5.906 1.00 34.88 A O ATOM 764 N LEU A 70 68.605 −48.185 −4.793 1.00 38.05 A N ATOM 765 CA LEU A 70 68.642 −47.417 −3.547 1.00 37.39 A C ATOM 767 CB LEU A 70 68.989 −48.320 −2.367 1.00 38.91 A C ATOM 770 CG LEU A 70 68.749 −47.727 −0.970 1.00 45.09 A C ATOM 772 CD1 LEU A 70 67.365 −47.093 −0.854 1.00 42.32 A C ATOM 776 CD2 LEU A 70 68.950 −48.819 0.092 1.00 48.11 A C ATOM 780 C LEU A 70 69.585 −46.208 −3.616 1.00 35.24 A C ATOM 781 O LEU A 70 69.273 −45.134 −3.076 1.00 33.59 A O ATOM 783 N THR A 71 70.715 −46.351 −4.308 1.00 32.18 A N ATOM 784 CA THR A 71 71.664 −45.232 −4.462 1.00 30.26 A C ATOM 786 CB THR A 71 72.975 −45.686 −5.151 1.00 31.18 A C ATOM 788 OG1 THR A 71 73.583 −46.737 −4.380 1.00 35.88 A O ATOM 790 CG2 THR A 71 73.957 −44.539 −5.269 1.00 32.21 A C ATOM 794 C THR A 71 71.023 −44.120 −5.277 1.00 27.98 A C ATOM 795 O THR A 71 71.215 −42.940 −5.011 1.00 29.70 A O ATOM 797 N LEU A 72 70.235 −44.508 −6.258 1.00 25.13 A N ATOM 798 CA LEU A 72 69.560 −43.566 −7.120 1.00 25.64 A C ATOM 800 CB LEU A 72 68.879 −44.315 −8.262 1.00 24.76 A C ATOM 803 CG LEU A 72 68.348 −43.417 −9.367 1.00 33.13 A C ATOM 805 CD1 LEU A 72 69.500 −42.625 −9.999 1.00 34.90 A C ATOM 809 CD2 LEU A 72 67.635 −44.244 −10.419 1.00 33.87 A C ATOM 813 C LEU A 72 68.515 −42.792 −6.344 1.00 25.13 A C ATOM 814 O LEU A 72 68.442 −41.559 −6.423 1.00 24.06 A O ATOM 816 N LEU A 73 67.705 −43.530 −5.593 1.00 24.72 A N ATOM 817 CA LEU A 73 66.685 −42.926 −4.767 1.00 24.94 A C ATOM 819 CB LEU A 73 65.863 −43.986 −4.053 1.00 25.13 A C ATOM 822 CG LEU A 73 65.002 −44.831 −4.983 1.00 24.35 A C ATOM 824 CD1 LEU A 73 64.535 −46.087 −4.255 1.00 25.41 A C ATOM 828 CD2 LEU A 73 63.853 −44.027 −5.559 1.00 20.54 A C ATOM 832 C LEU A 73 67.279 −41.941 −3.776 1.00 24.82 A C ATOM 833 O LEU A 73 66.697 −40.868 −3.534 1.00 24.80 A O ATOM 835 N GLU A 74 68.432 −42.287 −3.213 1.00 23.25 A N ATOM 836 CA GLU A 74 69.094 −41.412 −2.258 1.00 23.34 A C ATOM 838 CB GLU A 74 70.095 −42.214 −1.406 1.00 24.35 A C ATOM 841 CG GLU A 74 69.391 −43.188 −0.427 1.00 32.72 A C ATOM 844 CD GLU A 74 70.321 −43.919 0.537 1.00 43.15 A C ATOM 845 OE1 GLU A 74 71.558 −43.826 0.407 1.00 44.90 A O ATOM 846 OE2 GLU A 74 69.799 −44.603 1.438 1.00 48.93 A O ATOM 847 C GLU A 74 69.729 −40.186 −2.941 1.00 22.43 A C ATOM 848 O GLU A 74 69.785 −39.096 −2.362 1.00 24.16 A O ATOM 850 N LEU A 75 70.183 −40.335 −4.177 1.00 22.16 A N ATOM 851 CA LEU A 75 70.613 −39.180 −4.959 1.00 20.37 A C ATOM 853 CB LEU A 75 71.150 −39.622 −6.304 1.00 22.89 A C ATOM 856 CG LEU A 75 71.569 −38.495 −7.268 1.00 22.68 A C ATOM 858 CD1 LEU A 75 72.741 −37.711 −6.687 1.00 15.06 A C ATOM 862 CD2 LEU A 75 71.934 −39.153 −8.602 1.00 25.81 A C ATOM 866 C LEU A 75 69.465 −38.220 −5.224 1.00 20.23 A C ATOM 867 O LEU A 75 69.629 −37.017 −5.137 1.00 23.40 A O ATOM 869 N ILE A 76 68.307 −38.754 −5.582 1.00 21.55 A N ATOM 870 CA ILE A 76 67.174 −37.912 −5.923 1.00 23.06 A C ATOM 872 CB ILE A 76 65.974 −38.746 −6.401 1.00 22.62 A C ATOM 874 CG1 ILE A 76 66.259 −39.323 −7.790 1.00 24.94 A C ATOM 877 CD1 ILE A 76 65.388 −40.527 −8.171 1.00 19.96 A C ATOM 881 CG2 ILE A 76 64.717 −37.881 −6.400 1.00 19.22 A C ATOM 885 C ILE A 76 66.755 −37.093 −4.711 1.00 24.28 A C ATOM 886 O ILE A 76 66.472 −35.896 −4.821 1.00 26.54 A O ATOM 888 N ASP A 77 66.717 −37.761 −3.563 1.00 23.78 A N ATOM 889 CA ASP A 77 66.327 −37.154 −2.298 1.00 24.77 A C ATOM 891 CB ASP A 77 66.306 −38.227 −1.200 1.00 23.52 A C ATOM 894 CG ASP A 77 65.627 −37.769 0.071 1.00 30.63 A C ATOM 895 OD1 ASP A 77 64.773 −36.826 0.038 1.00 30.60 A O ATOM 896 OD2 ASP A 77 65.941 −38.387 1.119 1.00 33.55 A O ATOM 897 C ASP A 77 67.308 −36.068 −1.909 1.00 25.16 A C ATOM 898 O ASP A 77 66.907 −34.999 −1.440 1.00 24.30 A O ATOM 900 N ASN A 78 68.602 −36.348 −2.093 1.00 25.18 A N ATOM 901 CA ASN A 78 69.643 −35.372 −1.765 1.00 23.87 A C ATOM 903 CB ASN A 78 71.032 −36.003 −1.918 1.00 27.24 A C ATOM 906 CG ASN A 78 71.448 −36.844 −0.701 1.00 29.01 A C ATOM 907 OD1 ASN A 78 71.108 −36.503 0.421 1.00 29.64 A O ATOM 908 ND2 ASN A 78 72.208 −37.933 −0.928 1.00 22.29 A N ATOM 911 C ASN A 78 69.482 −34.154 −2.679 1.00 23.28 A C ATOM 912 O ASN A 78 69.488 −32.988 −2.235 1.00 22.07 A O ATOM 914 N VAL A 79 69.293 −34.431 −3.962 1.00 21.38 A N ATOM 915 CA VAL A 79 69.097 −33.364 −4.947 1.00 22.16 A C ATOM 917 CB VAL A 79 68.883 −33.961 −6.357 1.00 23.08 A C ATOM 919 CG1 VAL A 79 68.336 −32.907 −7.305 1.00 19.92 A C ATOM 923 CG2 VAL A 79 70.195 −34.593 −6.876 1.00 18.18 A C ATOM 927 C VAL A 79 67.892 −32.487 −4.573 1.00 21.06 A C ATOM 928 O VAL A 79 67.950 −31.257 −4.642 1.00 22.39 A O ATOM 930 N GLN A 80 66.805 −33.109 −4.155 1.00 20.41 A N ATOM 931 CA GLN A 80 65.613 −32.315 −3.760 1.00 21.13 A C ATOM 933 CB GLN A 80 64.376 −33.203 −3.656 1.00 19.81 A C ATOM 936 CG GLN A 80 64.025 −33.857 −5.004 1.00 16.22 A C ATOM 939 CD GLN A 80 62.628 −34.460 −5.034 1.00 23.03 A C ATOM 940 OE1 GLN A 80 61.984 −34.492 −6.087 1.00 19.49 A O ATOM 941 NE2 GLN A 80 62.146 −34.930 −3.873 1.00 19.16 A N ATOM 944 C GLN A 80 65.829 −31.542 −2.465 1.00 22.00 A C ATOM 945 O GLN A 80 65.497 −30.360 −2.366 1.00 25.58 A O ATOM 947 N ARG A 81 66.399 −32.200 −1.475 1.00 20.76 A N ATOM 948 CA ARG A 81 66.557 −31.579 −0.171 1.00 22.60 A C ATOM 950 CB ARG A 81 67.004 −32.619 0.840 1.00 22.73 A C ATOM 953 CG ARG A 81 65.896 −33.644 1.107 1.00 27.58 A C ATOM 956 CD ARG A 81 66.200 −34.449 2.360 1.00 26.39 A C ATOM 959 NE ARG A 81 66.352 −33.563 3.508 1.00 33.93 A N ATOM 961 CZ ARG A 81 66.523 −33.991 4.754 1.00 44.75 A C ATOM 962 NH1 ARG A 81 66.529 −35.296 5.011 1.00 46.21 A N ATOM 965 NH2 ARG A 81 66.665 −33.114 5.747 1.00 38.64 A N ATOM 968 C ARG A 81 67.534 −30.418 −0.225 1.00 21.64 A C ATOM 969 O ARG A 81 67.329 −29.389 0.424 1.00 22.17 A O ATOM 971 N LEU A 82 68.575 −30.578 −1.032 1.00 18.90 A N ATOM 972 CA LEU A 82 69.556 −29.522 −1.230 1.00 16.62 A C ATOM 974 CB LEU A 82 70.796 −30.076 −1.937 1.00 15.07 A C ATOM 977 CG LEU A 82 71.610 −31.097 −1.137 1.00 19.59 A C ATOM 979 CD1 LEU A 82 72.585 −31.806 −2.061 1.00 19.94 A C ATOM 983 CD2 LEU A 82 72.325 −30.424 0.043 1.00 16.09 A C ATOM 987 C LEU A 82 68.998 −28.356 −2.013 1.00 17.05 A C ATOM 988 O LEU A 82 69.691 −27.374 −2.197 1.00 18.11 A O ATOM 990 N GLY A 83 67.759 −28.470 −2.490 1.00 19.79 A N ATOM 991 CA GLY A 83 67.064 −27.359 −3.130 1.00 20.72 A C ATOM 994 C GLY A 83 67.100 −27.353 −4.651 1.00 21.28 A C ATOM 995 O GLY A 83 66.622 −26.412 −5.277 1.00 21.81 A O ATOM 997 N LEU A 84 67.620 −28.418 −5.254 1.00 22.14 A N ATOM 998 CA LEU A 84 67.836 −28.450 −6.704 1.00 22.65 A C ATOM 1000 CB LEU A 84 69.193 −29.092 −6.998 1.00 20.71 A C ATOM 1003 CG LEU A 84 70.398 −28.272 −6.564 1.00 21.65 A C ATOM 1005 CD1 LEU A 84 71.625 −29.158 −6.493 1.00 18.26 A C ATOM 1009 CD2 LEU A 84 70.634 −27.090 −7.483 1.00 14.55 A C ATOM 1013 C LEU A 84 66.744 −29.200 −7.505 1.00 24.69 A C ATOM 1014 O LEU A 84 66.853 −29.305 −8.734 1.00 24.25 A O ATOM 1016 N GLY A 85 65.718 −29.718 −6.826 1.00 23.20 A N ATOM 1017 CA GLY A 85 64.646 −30.512 −7.476 1.00 24.92 A C ATOM 1020 C GLY A 85 63.962 −29.846 −8.659 1.00 24.61 A C ATOM 1021 O GLY A 85 63.792 −30.465 −9.714 1.00 26.70 A O ATOM 1023 N TYR A 86 63.625 −28.570 −8.511 1.00 26.13 A N ATOM 1024 CA TYR A 86 63.032 −27.765 −9.616 1.00 27.13 A C ATOM 1026 CB TYR A 86 62.880 −26.295 −9.195 1.00 25.38 A C ATOM 1029 CG TYR A 86 64.180 −25.458 −9.276 1.00 21.72 A C ATOM 1030 CD1 TYR A 86 64.428 −24.637 −10.362 1.00 19.43 A C ATOM 1032 CE1 TYR A 86 65.582 −23.874 −10.435 1.00 24.50 A C ATOM 1034 CZ TYR A 86 66.513 −23.916 −9.398 1.00 20.21 A C ATOM 1035 OH TYR A 86 67.655 −23.164 −9.489 1.00 16.34 A O ATOM 1037 CE2 TYR A 86 66.287 −24.695 −8.297 1.00 15.09 A C ATOM 1039 CD2 TYR A 86 65.123 −25.470 −8.235 1.00 20.89 A C ATOM 1041 C TYR A 86 63.861 −27.803 −10.904 1.00 28.47 A C ATOM 1042 O TYR A 86 63.369 −27.573 −12.003 1.00 33.02 A O ATOM 1044 N ARG A 87 65.140 −28.075 −10.752 1.00 28.58 A N ATOM 1045 CA ARG A 87 66.067 −28.023 −11.854 1.00 28.18 A C ATOM 1047 CB ARG A 87 67.395 −27.694 −11.215 1.00 29.83 A C ATOM 1050 CG ARG A 87 68.405 −27.210 −12.098 1.00 31.31 A C ATOM 1053 CD ARG A 87 69.334 −26.189 −11.405 1.00 29.77 A C ATOM 1056 NE ARG A 87 69.857 −25.501 −12.548 1.00 28.60 A N ATOM 1058 CZ ARG A 87 69.522 −24.301 −12.934 1.00 21.90 A C ATOM 1059 NH1 ARG A 87 70.033 −23.874 −14.064 1.00 36.21 A N ATOM 1062 NH2 ARG A 87 68.772 −23.510 −12.182 1.00 22.93 A N ATOM 1065 C ARG A 87 66.115 −29.349 −12.639 1.00 27.31 A C ATOM 1066 O ARG A 87 66.425 −29.375 −13.824 1.00 27.32 A O ATOM 1068 N PHE A 88 65.773 −30.448 −11.982 1.00 26.33 A N ATOM 1069 CA PHE A 88 65.973 −31.773 −12.557 1.00 26.77 A C ATOM 1071 CB PHE A 88 66.993 −32.547 −11.717 1.00 24.89 A C ATOM 1074 CG PHE A 88 68.349 −31.933 −11.722 1.00 24.57 A C ATOM 1075 CD1 PHE A 88 69.151 −32.027 −12.851 1.00 22.34 A C ATOM 1077 CE1 PHE A 88 70.407 −31.449 −12.879 1.00 24.25 A C ATOM 1079 CZ PHE A 88 70.870 −30.733 −11.773 1.00 24.17 A C ATOM 1081 CE2 PHE A 88 70.069 −30.614 −10.653 1.00 22.88 A C ATOM 1083 CD2 PHE A 88 68.808 −31.217 −10.629 1.00 21.57 A C ATOM 1085 C PHE A 88 64.687 −32.558 −12.629 1.00 27.69 A C ATOM 1086 O PHE A 88 64.708 −33.773 −12.532 1.00 28.94 A O ATOM 1088 N GLU A 89 63.571 −31.870 −12.834 1.00 29.75 A N ATOM 1089 CA GLU A 89 62.274 −32.508 −12.692 1.00 32.99 A C ATOM 1091 CB GLU A 89 61.102 −31.513 −12.765 1.00 33.37 A C ATOM 1094 CG GLU A 89 59.763 −32.231 −12.470 1.00 46.55 A C ATOM 1097 CD GLU A 89 58.580 −31.316 −12.217 1.00 57.05 A C ATOM 1098 OE1 GLU A 89 58.729 −30.328 −11.448 1.00 60.68 A O ATOM 1099 OE2 GLU A 89 57.496 −31.622 −12.775 1.00 57.95 A O ATOM 1100 C GLU A 89 62.042 −33.637 −13.678 1.00 32.53 A C ATOM 1101 O GLU A 89 61.662 −34.736 −13.269 1.00 32.44 A O ATOM 1103 N SER A 90 62.244 −33.379 −14.965 1.00 31.61 A N ATOM 1104 CA SER A 90 62.011 −34.420 −15.965 1.00 32.03 A C ATOM 1106 CB SER A 90 62.136 −33.884 −17.397 1.00 32.86 A C ATOM 1109 OG SER A 90 63.207 −32.968 −17.531 1.00 41.77 A O ATOM 1111 C SER A 90 62.947 −35.591 −15.756 1.00 29.81 A C ATOM 1112 O SER A 90 62.586 −36.718 −16.032 1.00 31.36 A O ATOM 1114 N ASP A 91 64.154 −35.326 −15.256 1.00 28.19 A N ATOM 1115 CA ASP A 91 65.126 −36.396 −15.014 1.00 24.23 A C ATOM 1117 CB ASP A 91 66.521 −35.807 −14.750 1.00 23.78 A C ATOM 1120 CG ASP A 91 66.966 −34.819 −15.851 1.00 27.08 A C ATOM 1121 OD1 ASP A 91 67.311 −35.261 −16.954 1.00 33.39 A O ATOM 1122 OD2 ASP A 91 66.968 −33.601 −15.619 1.00 36.51 A O ATOM 1123 C ASP A 91 64.657 −37.237 −13.820 1.00 25.06 A C ATOM 1124 O ASP A 91 64.691 −38.467 −13.864 1.00 22.54 A O ATOM 1126 N ILE A 92 64.213 −36.573 −12.749 1.00 22.98 A N ATOM 1127 CA ILE A 92 63.739 −37.290 −11.568 1.00 23.78 A C ATOM 1129 CB ILE A 92 63.401 −36.337 −10.446 1.00 22.94 A C ATOM 1131 CG1 ILE A 92 64.687 −35.861 −9.804 1.00 19.21 A C ATOM 1134 CD1 ILE A 92 64.563 −34.555 −9.062 1.00 17.83 A C ATOM 1138 CG2 ILE A 92 62.526 −37.040 −9.414 1.00 23.71 A C ATOM 1142 C ILE A 92 62.509 −38.135 −11.919 1.00 24.89 A C ATOM 1143 O ILE A 92 62.486 −39.327 −11.669 1.00 23.25 A O ATOM 1145 N ARG A 93 61.513 −37.524 −12.542 1.00 26.25 A N ATOM 1146 CA ARG A 93 60.331 −38.275 −12.964 1.00 28.67 A C ATOM 1148 CB ARG A 93 59.345 −37.394 −13.747 1.00 30.12 A C ATOM 1151 CG ARG A 93 58.786 −36.167 −13.040 1.00 34.31 A C ATOM 1154 CD ARG A 93 57.781 −35.434 −14.024 1.00 38.26 A C ATOM 1157 NE ARG A 93 56.850 −36.429 −14.548 1.00 40.69 A N ATOM 1159 CZ ARG A 93 55.847 −36.955 −13.847 1.00 45.91 A C ATOM 1160 NH1 ARG A 93 55.602 −36.551 −12.602 1.00 47.58 A N ATOM 1163 NH2 ARG A 93 55.059 −37.874 −14.392 1.00 49.96 A N ATOM 1166 C ARG A 93 60.712 −39.443 −13.877 1.00 28.48 A C ATOM 1167 O ARG A 93 60.134 −40.512 −13.783 1.00 28.33 A O ATOM 1169 N GLY A 94 61.655 −39.219 −14.790 1.00 27.77 A N ATOM 1170 CA GLY A 94 62.097 −40.281 −15.692 1.00 26.95 A C ATOM 1173 C GLY A 94 62.607 −41.477 −14.914 1.00 28.30 A C ATOM 1174 O GLY A 94 62.298 −42.631 −15.231 1.00 30.24 A O ATOM 1176 N ALA A 95 63.390 −41.203 −13.882 1.00 25.47 A N ATOM 1177 CA ALA A 95 64.045 −42.254 −13.123 1.00 25.65 A C ATOM 1179 CB ALA A 95 65.183 −41.658 −12.263 1.00 23.46 A C ATOM 1183 C ALA A 95 63.044 −42.991 −12.250 1.00 25.68 A C ATOM 1184 O ALA A 95 63.149 −44.208 −12.070 1.00 27.08 A O ATOM 1186 N LEU A 96 62.073 −42.266 −11.711 1.00 24.42 A N ATOM 1187 CA LEU A 96 61.032 −42.899 −10.893 1.00 25.56 A C ATOM 1189 CB LEU A 96 60.201 −41.851 −10.150 1.00 24.25 A C ATOM 1192 CG LEU A 96 60.979 −41.085 −9.090 1.00 26.81 A C ATOM 1194 CD1 LEU A 96 60.175 −39.926 −8.563 1.00 21.85 A C ATOM 1198 CD2 LEU A 96 61.365 −42.017 −7.974 1.00 23.10 A C ATOM 1202 C LEU A 96 60.121 −43.764 −11.755 1.00 27.28 A C ATOM 1203 O LEU A 96 59.707 −44.848 −11.352 1.00 24.29 A O ATOM 1205 N ASP A 97 59.805 −43.278 −12.952 1.00 31.37 A N ATOM 1206 CA ASP A 97 59.040 −44.080 −13.895 1.00 34.30 A C ATOM 1208 CB ASP A 97 58.875 −43.351 −15.205 1.00 34.30 A C ATOM 1211 CG ASP A 97 57.901 −44.050 −16.125 1.00 47.50 A C ATOM 1212 OD1 ASP A 97 58.360 −44.783 −17.041 1.00 55.79 A O ATOM 1213 OD2 ASP A 97 56.676 −43.884 −15.908 1.00 54.69 A O ATOM 1214 C ASP A 97 59.735 −45.428 −14.131 1.00 35.14 A C ATOM 1215 O ASP A 97 59.110 −46.485 −14.136 1.00 34.56 A O ATOM 1217 N ARG A 98 61.043 −45.376 −14.299 1.00 36.78 A N ATOM 1218 CA ARG A 98 61.813 −46.568 −14.600 1.00 38.34 A C ATOM 1220 CB ARG A 98 63.232 −46.187 −15.013 1.00 38.88 A C ATOM 1223 CG ARG A 98 63.620 −46.641 −16.400 1.00 43.64 A C ATOM 1226 CD ARG A 98 64.485 −45.611 −17.145 1.00 43.57 A C ATOM 1229 NE ARG A 98 65.396 −44.847 −16.278 1.00 39.48 A N ATOM 1231 CZ ARG A 98 65.577 −43.522 −16.340 1.00 34.93 A C ATOM 1232 NH1 ARG A 98 64.927 −42.778 −17.238 1.00 36.94 A N ATOM 1235 NH2 ARG A 98 66.431 −42.932 −15.512 1.00 36.51 A N ATOM 1238 C ARG A 98 61.842 −47.475 −13.379 1.00 37.58 A C ATOM 1239 O ARG A 98 61.787 −48.692 −13.519 1.00 38.96 A O ATOM 1241 N PHE A 99 61.928 −46.879 −12.192 1.00 35.87 A N ATOM 1242 CA PHE A 99 61.924 −47.629 −10.948 1.00 36.10 A C ATOM 1244 CB PHE A 99 62.170 −46.693 −9.756 1.00 37.12 A C ATOM 1247 CG PHE A 99 62.224 −47.401 −8.427 1.00 34.31 A C ATOM 1248 CD1 PHE A 99 63.223 −48.307 −8.162 1.00 37.07 A C ATOM 1250 CE1 PHE A 99 63.275 −48.973 −6.943 1.00 37.15 A C ATOM 1252 CZ PHE A 99 62.322 −48.714 −5.970 1.00 35.62 A C ATOM 1254 CE2 PHE A 99 61.329 −47.799 −6.221 1.00 30.23 A C ATOM 1256 CD2 PHE A 99 61.271 −47.153 −7.444 1.00 34.40 A C ATOM 1258 C PHE A 99 60.614 −48.406 −10.759 1.00 36.72 A C ATOM 1259 O PHE A 99 60.617 −49.513 −10.213 1.00 37.39 A O ATOM 1261 N VAL A 100 59.502 −47.838 −11.202 1.00 35.36 A N ATOM 1262 CA VAL A 100 58.258 −48.570 −11.191 1.00 38.56 A C ATOM 1264 CB VAL A 100 57.054 −47.635 −11.263 1.00 40.72 A C ATOM 1266 CG1 VAL A 100 55.755 −48.457 −11.465 1.00 37.62 A C ATOM 1270 CG2 VAL A 100 56.985 −46.787 −9.999 1.00 33.69 A C ATOM 1274 C VAL A 100 58.202 −49.563 −12.367 1.00 41.18 A C ATOM 1275 O VAL A 100 57.974 −50.760 −12.164 1.00 40.05 A O ATOM 1277 N SER A 101 58.437 −49.072 −13.585 1.00 42.95 A N ATOM 1278 CA SER A 101 58.207 −49.880 −14.799 1.00 45.08 A C ATOM 1280 CB SER A 101 58.507 −49.087 −16.079 1.00 46.29 A C ATOM 1283 OG SER A 101 59.856 −49.282 −16.492 1.00 50.51 A O ATOM 1285 C SER A 101 59.010 −51.169 −14.802 1.00 44.71 A C ATOM 1286 O SER A 101 58.550 −52.167 −15.313 1.00 46.34 A O ATOM 1288 N SER A 102 60.200 −51.136 −14.218 1.00 44.39 A N ATOM 1289 CA SER A 102 61.053 −52.306 −14.113 1.00 45.16 A C ATOM 1291 CB SER A 102 62.506 −51.847 −13.944 1.00 46.36 A C ATOM 1294 OG SER A 102 62.747 −51.406 −12.615 1.00 47.55 A O ATOM 1296 C SER A 102 60.712 −53.225 −12.925 1.00 45.37 A C ATOM 1297 O SER A 102 61.418 −54.185 −12.672 1.00 44.04 A O ATOM 1299 N GLY A 103 59.669 −52.904 −12.167 1.00 46.21 A N ATOM 1300 CA GLY A 103 59.343 −53.663 −10.955 1.00 46.61 A C ATOM 1303 C GLY A 103 60.241 −53.437 −9.745 1.00 45.81 A C ATOM 1304 O GLY A 103 60.133 −54.155 −8.747 1.00 46.61 A O ATOM 1306 N GLY A 104 61.123 −52.444 −9.817 1.00 45.47 A N ATOM 1307 CA GLY A 104 62.011 −52.136 −8.702 1.00 44.33 A C ATOM 1310 C GLY A 104 61.271 −51.766 −7.434 1.00 42.90 A C ATOM 1311 O GLY A 104 61.640 −52.210 −6.339 1.00 43.32 A O ATOM 1313 N PHE A 105 60.228 −50.955 −7.574 1.00 41.44 A N ATOM 1314 CA PHE A 105 59.401 −50.578 −6.426 1.00 42.25 A C ATOM 1316 CB PHE A 105 58.309 −49.569 −6.800 1.00 40.65 A C ATOM 1319 CG PHE A 105 57.434 −49.159 −5.634 1.00 39.69 A C ATOM 1320 CD1 PHE A 105 57.991 −48.615 −4.485 1.00 35.48 A C ATOM 1322 CE1 PHE A 105 57.189 −48.232 −3.411 1.00 38.34 A C ATOM 1324 CZ PHE A 105 55.816 −48.397 −3.486 1.00 41.55 A C ATOM 1326 CE2 PHE A 105 55.253 −48.938 −4.612 1.00 38.70 A C ATOM 1328 CD2 PHE A 105 56.058 −49.308 −5.687 1.00 42.66 A C ATOM 1330 C PHE A 105 58.765 −51.800 −5.799 1.00 43.53 A C ATOM 1331 O PHE A 105 58.700 −51.904 −4.584 1.00 42.87 A O ATOM 1333 N ASP A 106 58.297 −52.729 −6.623 1.00 46.74 A N ATOM 1334 CA ASP A 106 57.714 −53.948 −6.093 1.00 49.25 A C ATOM 1336 CB ASP A 106 57.058 −54.776 −7.199 1.00 52.47 A C ATOM 1339 CG ASP A 106 55.671 −55.256 −6.807 1.00 60.96 A C ATOM 1340 OD1 ASP A 106 54.826 −54.386 −6.468 1.00 69.59 A O ATOM 1341 OD2 ASP A 106 55.436 −56.486 −6.828 1.00 66.22 A O ATOM 1342 C ASP A 106 58.775 −54.756 −5.354 1.00 48.33 A C ATOM 1343 O ASP A 106 58.521 −55.290 −4.271 1.00 48.27 A O ATOM 1345 N ALA A 107 59.971 −54.821 −5.927 1.00 46.84 A N ATOM 1346 CA ALA A 107 61.096 −55.440 −5.246 1.00 45.49 A C ATOM 1348 CB ALA A 107 62.380 −55.283 −6.070 1.00 46.29 A C ATOM 1352 C ALA A 107 61.285 −54.846 −3.853 1.00 44.32 A C ATOM 1353 O ALA A 107 61.248 −55.581 −2.861 1.00 45.24 A O ATOM 1355 N VAL A 108 61.468 −53.527 −3.752 1.00 42.93 A N ATOM 1356 CA VAL A 108 61.877 −52.954 −2.458 1.00 40.66 A C ATOM 1358 CB VAL A 108 62.288 −51.469 −2.511 1.00 41.66 A C ATOM 1360 CG1 VAL A 108 63.411 −51.263 −3.531 1.00 48.84 A C ATOM 1364 CG2 VAL A 108 61.078 −50.566 −2.778 1.00 34.77 A C ATOM 1368 C VAL A 108 60.835 −53.130 −1.373 1.00 39.03 A C ATOM 1369 O VAL A 108 61.198 −53.207 −0.210 1.00 38.61 A O ATOM 1371 N THR A 109 59.558 −53.220 −1.739 1.00 39.24 A N ATOM 1372 CA THR A 109 58.504 −53.460 −0.747 1.00 40.61 A C ATOM 1374 CB THR A 109 57.078 −53.384 −1.330 1.00 40.51 A C ATOM 1376 OG1 THR A 109 56.840 −54.523 −2.162 1.00 40.09 A O ATOM 1378 CG2 THR A 109 56.853 −52.075 −2.115 1.00 38.58 A C ATOM 1382 C THR A 109 58.656 −54.815 −0.042 1.00 42.53 A C ATOM 1383 O THR A 109 58.130 −54.999 1.061 1.00 42.34 A O ATOM 1385 N LYS A 110 59.365 −55.751 −0.673 1.00 44.78 A N ATOM 1386 CA LYS A 110 59.616 −57.080 −0.082 1.00 47.15 A C ATOM 1388 CB LYS A 110 59.788 −58.164 −1.164 1.00 48.00 A C ATOM 1391 CG LYS A 110 58.761 −58.189 −2.295 1.00 52.11 A C ATOM 1394 CD LYS A 110 57.351 −58.484 −1.819 1.00 60.28 A C ATOM 1397 CE LYS A 110 56.382 −58.578 −3.010 1.00 65.15 A C ATOM 1400 NZ LYS A 110 55.021 −58.046 −2.683 1.00 64.69 A N ATOM 1404 C LYS A 110 60.873 −57.096 0.778 1.00 46.28 A C ATOM 1405 O LYS A 110 61.028 −57.984 1.603 1.00 47.54 A O ATOM 1407 N THR A 111 61.770 −56.131 0.570 1.00 46.36 A N ATOM 1408 CA THR A 111 63.123 −56.191 1.133 1.00 45.50 A C ATOM 1410 CB THR A 111 64.197 −56.315 0.003 1.00 47.36 A C ATOM 1412 OG1 THR A 111 64.312 −55.076 −0.711 1.00 50.35 A O ATOM 1414 CG2 THR A 111 63.837 −57.451 −1.000 1.00 47.26 A C ATOM 1418 C THR A 111 63.530 −55.041 2.061 1.00 44.00 A C ATOM 1419 O THR A 111 64.272 −55.284 3.019 1.00 44.86 A O ATOM 1421 N SER A 112 63.078 −53.806 1.798 1.00 40.92 A N ATOM 1422 CA SER A 112 63.645 −52.611 2.480 1.00 37.38 A C ATOM 1424 CB SER A 112 64.723 −51.988 1.578 1.00 38.61 A C ATOM 1427 OG SER A 112 65.350 −50.861 2.173 1.00 42.50 A O ATOM 1429 C SER A 112 62.600 −51.542 2.889 1.00 33.43 A C ATOM 1430 O SER A 112 61.986 −50.896 2.037 1.00 31.07 A O ATOM 1432 N LEU A 113 62.399 −51.372 4.194 1.00 29.38 A N ATOM 1433 CA LEU A 113 61.529 −50.323 4.709 1.00 29.45 A C ATOM 1435 CB LEU A 113 61.443 −50.353 6.241 1.00 29.86 A C ATOM 1438 CG LEU A 113 60.553 −49.263 6.868 1.00 31.38 A C ATOM 1440 CD1 LEU A 113 59.109 −49.437 6.427 1.00 29.65 A C ATOM 1444 CD2 LEU A 113 60.631 −49.299 8.378 1.00 33.60 A C ATOM 1448 C LEU A 113 62.017 −48.954 4.268 1.00 28.16 A C ATOM 1449 O LEU A 113 61.237 −48.138 3.810 1.00 29.40 A O ATOM 1451 N HIS A 114 63.308 −48.706 4.417 1.00 27.25 A N ATOM 1452 CA HIS A 114 63.902 −47.461 3.960 1.00 28.38 A C ATOM 1454 CB HIS A 114 65.418 −47.448 4.175 1.00 29.85 A C ATOM 1457 CG HIS A 114 66.073 −46.214 3.663 1.00 29.52 A C ATOM 1458 ND1 HIS A 114 65.529 −44.961 3.846 1.00 36.46 A N ATOM 1460 CE1 HIS A 114 66.310 −44.057 3.281 1.00 35.11 A C ATOM 1462 NE2 HIS A 114 67.322 −44.682 2.711 1.00 36.38 A N ATOM 1464 CD2 HIS A 114 67.197 −46.033 2.937 1.00 36.40 A C ATOM 1466 C HIS A 114 63.595 −47.220 2.493 1.00 27.08 A C ATOM 1467 O HIS A 114 63.089 −46.166 2.127 1.00 25.36 A O ATOM 1469 N GLY A 115 63.884 −48.214 1.665 1.00 27.32 A N ATOM 1470 CA GLY A 115 63.647 −48.120 0.234 1.00 25.75 A C ATOM 1473 C GLY A 115 62.184 −47.904 −0.102 1.00 26.39 A C ATOM 1474 O GLY A 115 61.858 −47.150 −1.041 1.00 26.71 A O ATOM 1476 N THR A 116 61.306 −48.567 0.657 1.00 24.29 A N ATOM 1477 CA THR A 116 59.865 −48.470 0.431 1.00 24.57 A C ATOM 1479 CB THR A 116 59.111 −49.555 1.168 1.00 25.44 A C ATOM 1481 OG1 THR A 116 59.620 −50.825 0.738 1.00 27.83 A O ATOM 1483 CG2 THR A 116 57.589 −49.476 0.868 1.00 20.09 A C ATOM 1487 C THR A 116 59.307 −47.113 0.832 1.00 25.48 A C ATOM 1488 O THR A 116 58.594 −46.491 0.046 1.00 25.53 A O ATOM 1490 N ALA A 117 59.659 −46.647 2.028 1.00 23.44 A N ATOM 1491 CA ALA A 117 59.194 −45.356 2.505 1.00 24.19 A C ATOM 1493 CB ALA A 117 59.478 −45.193 4.016 1.00 23.46 A C ATOM 1497 C ALA A 117 59.791 −44.201 1.699 1.00 24.21 A C ATOM 1498 O ALA A 117 59.112 −43.225 1.436 1.00 23.16 A O ATOM 1500 N LEU A 118 61.048 −44.301 1.286 1.00 24.65 A N ATOM 1501 CA LEU A 118 61.631 −43.222 0.443 1.00 25.43 A C ATOM 1503 CB LEU A 118 63.157 −43.356 0.339 1.00 24.64 A C ATOM 1506 CG LEU A 118 63.924 −42.343 −0.519 1.00 29.58 A C ATOM 1508 CD1 LEU A 118 63.697 −40.923 −0.069 1.00 22.30 A C ATOM 1512 CD2 LEU A 118 65.403 −42.690 −0.477 1.00 24.34 A C ATOM 1516 C LEU A 118 60.986 −43.203 −0.936 1.00 24.40 A C ATOM 1517 O LEU A 118 60.497 −42.172 −1.409 1.00 24.21 A O ATOM 1519 N SER A 119 60.943 −44.362 −1.580 1.00 25.13 A N ATOM 1520 CA SER A 119 60.368 −44.416 −2.916 1.00 23.95 A C ATOM 1522 CB SER A 119 60.589 −45.779 −3.563 1.00 25.32 A C ATOM 1525 OG SER A 119 59.934 −46.812 −2.867 1.00 26.72 A O ATOM 1527 C SER A 119 58.892 −44.054 −2.902 1.00 23.29 A C ATOM 1528 O SER A 119 58.429 −43.326 −3.770 1.00 23.89 A O ATOM 1530 N PHE A 120 58.162 −44.537 −1.903 1.00 22.65 A N ATOM 1531 CA PHE A 120 56.760 −44.152 −1.715 1.00 22.34 A C ATOM 1533 CB PHE A 120 56.202 −44.766 −0.422 1.00 22.44 A C ATOM 1536 CG PHE A 120 54.758 −44.427 −0.154 1.00 23.67 A C ATOM 1537 CD1 PHE A 120 53.752 −45.312 −0.480 1.00 26.16 A C ATOM 1539 CE1 PHE A 120 52.413 −45.001 −0.220 1.00 26.81 A C ATOM 1541 CZ PHE A 120 52.092 −43.791 0.378 1.00 23.94 A C ATOM 1543 CE2 PHE A 120 53.089 −42.932 0.722 1.00 23.73 A C ATOM 1545 CD2 PHE A 120 54.414 −43.240 0.454 1.00 25.92 A C ATOM 1547 C PHE A 120 56.606 −42.630 −1.669 1.00 20.61 A C ATOM 1548 O PHE A 120 55.759 −42.066 −2.345 1.00 19.01 A O ATOM 1550 N ARG A 121 57.410 −41.966 −0.850 1.00 19.18 A N ATOM 1551 CA ARG A 121 57.326 −40.506 −0.775 1.00 20.59 A C ATOM 1553 CB ARG A 121 58.263 −39.962 0.293 1.00 20.27 A C ATOM 1556 CG ARG A 121 58.293 −38.443 0.373 1.00 20.89 A C ATOM 1559 CD ARG A 121 58.902 −37.979 1.690 1.00 25.20 A C ATOM 1562 NE ARG A 121 60.315 −38.344 1.819 1.00 23.57 A N ATOM 1564 CZ ARG A 121 61.313 −37.708 1.209 1.00 23.54 A C ATOM 1565 NH1 ARG A 121 61.068 −36.674 0.414 1.00 25.58 A N ATOM 1568 NH2 ARG A 121 62.566 −38.101 1.399 1.00 26.88 A N ATOM 1571 C ARG A 121 57.648 −39.851 −2.127 1.00 19.48 A C ATOM 1572 O ARG A 121 56.909 −38.997 −2.609 1.00 19.29 A O ATOM 1574 N LEU A 122 58.759 −40.238 −2.730 1.00 18.56 A N ATOM 1575 CA LEU A 122 59.159 −39.613 −4.017 1.00 20.57 A C ATOM 1577 CB LEU A 122 60.537 −40.098 −4.452 1.00 18.26 A C ATOM 1580 CG LEU A 122 61.666 −39.788 −3.466 1.00 21.60 A C ATOM 1582 CD1 LEU A 122 62.946 −40.470 −3.896 1.00 21.70 A C ATOM 1586 CD2 LEU A 122 61.855 −38.314 −3.393 1.00 16.48 A C ATOM 1590 C LEU A 122 58.121 −39.881 −5.129 1.00 20.63 A C ATOM 1591 O LEU A 122 57.780 −39.002 −5.914 1.00 21.52 A O ATOM 1593 N LEU A 123 57.594 −41.088 −5.167 1.00 20.62 A N ATOM 1594 CA LEU A 123 56.623 −41.439 −6.195 1.00 20.75 A C ATOM 1596 CB LEU A 123 56.330 −42.919 −6.128 1.00 20.28 A C ATOM 1599 CG LEU A 123 57.412 −43.829 −6.735 1.00 22.58 A C ATOM 1601 CD1 LEU A 123 57.134 −45.289 −6.354 1.00 20.41 A C ATOM 1605 CD2 LEU A 123 57.468 −43.716 −8.242 1.00 19.56 A C ATOM 1609 C LEU A 123 55.345 −40.604 −6.046 1.00 21.54 A C ATOM 1610 O LEU A 123 54.858 −39.995 −7.011 1.00 20.27 A O ATOM 1612 N ARG A 124 54.820 −40.534 −4.829 1.00 22.21 A N ATOM 1613 CA ARG A 124 53.585 −39.797 −4.615 1.00 20.97 A C ATOM 1615 CB ARG A 124 52.987 −40.096 −3.246 1.00 19.35 A C ATOM 1618 CG ARG A 124 51.792 −39.228 −2.932 1.00 23.37 A C ATOM 1621 CD ARG A 124 51.015 −39.762 −1.753 1.00 23.81 A C ATOM 1624 NE ARG A 124 50.298 −41.008 −2.048 1.00 20.90 A N ATOM 1626 CZ ARG A 124 49.550 −41.652 −1.158 1.00 23.68 A C ATOM 1627 NH1 ARG A 124 49.450 −41.192 0.085 1.00 19.23 A N ATOM 1630 NH2 ARG A 124 48.900 −42.746 −1.502 1.00 20.41 A N ATOM 1633 C ARG A 124 53.831 −38.321 −4.814 1.00 18.12 A C ATOM 1634 O ARG A 124 53.021 −37.627 −5.402 1.00 21.48 A O ATOM 1636 N GLN A 125 54.959 −37.831 −4.343 1.00 20.20 A N ATOM 1637 CA GLN A 125 55.321 −36.430 −4.584 1.00 21.03 A C ATOM 1639 CB GLN A 125 56.744 −36.147 −4.080 1.00 21.65 A C ATOM 1642 CG GLN A 125 57.280 −34.765 −4.498 1.00 20.36 A C ATOM 1645 CD GLN A 125 58.726 −34.527 −4.121 1.00 26.60 A C ATOM 1646 OE1 GLN A 125 59.381 −35.390 −3.526 1.00 21.64 A O ATOM 1647 NE2 GLN A 125 59.247 −33.352 −4.492 1.00 18.29 A N ATOM 1650 C GLN A 125 55.266 −36.089 −6.080 1.00 21.86 A C ATOM 1651 O GLN A 125 54.826 −34.999 −6.477 1.00 23.50 A O ATOM 1653 N HIS A 126 55.739 −37.011 −6.912 1.00 22.17 A N ATOM 1654 CA HIS A 126 55.787 −36.760 −8.350 1.00 23.23 A C ATOM 1656 CB HIS A 126 57.100 −37.293 −8.904 1.00 23.41 A C ATOM 1659 CG HIS A 126 58.250 −36.415 −8.563 1.00 20.04 A C ATOM 1660 ND1 HIS A 126 58.516 −35.260 −9.256 1.00 26.32 A N ATOM 1662 CE1 HIS A 126 59.541 −34.646 −8.700 1.00 22.03 A C ATOM 1664 NE2 HIS A 126 59.942 −35.359 −7.667 1.00 19.54 A N ATOM 1666 CD2 HIS A 126 59.139 −36.463 −7.548 1.00 18.20 A C ATOM 1668 C HIS A 126 54.568 −37.274 −9.096 1.00 25.26 A C ATOM 1669 O HIS A 126 54.602 −37.438 −10.311 1.00 26.07 A O ATOM 1671 N GLY A 127 53.479 −37.528 −8.371 1.00 25.78 A N ATOM 1672 CA GLY A 127 52.198 −37.783 −9.033 1.00 24.01 A C ATOM 1675 C GLY A 127 51.898 −39.232 −9.348 1.00 23.73 A C ATOM 1676 O GLY A 127 50.879 −39.513 −9.937 1.00 28.90 A O ATOM 1678 N PHE A 128 52.763 −40.163 −8.977 1.00 23.33 A N ATOM 1679 CA PHE A 128 52.490 −41.563 −9.251 1.00 25.32 A C ATOM 1681 CB PHE A 128 53.775 −42.381 −9.271 1.00 23.93 A C ATOM 1684 CG PHE A 128 54.725 −42.003 −10.366 1.00 26.62 A C ATOM 1685 CD1 PHE A 128 54.739 −42.698 −11.555 1.00 27.05 A C ATOM 1687 CE1 PHE A 128 55.633 −42.369 −12.551 1.00 30.59 A C ATOM 1689 CZ PHE A 128 56.513 −41.321 −12.368 1.00 33.45 A C ATOM 1691 CE2 PHE A 128 56.500 −40.627 −11.187 1.00 30.11 A C ATOM 1693 CD2 PHE A 128 55.629 −40.979 −10.194 1.00 25.68 A C ATOM 1695 C PHE A 128 51.535 −42.136 −8.193 1.00 28.35 A C ATOM 1696 O PHE A 128 51.473 −41.657 −7.062 1.00 28.35 A O ATOM 1698 N GLU A 129 50.828 −43.178 −8.584 1.00 30.58 A N ATOM 1699 CA GLU A 129 49.896 −43.880 −7.739 1.00 33.23 A C ATOM 1701 CB GLU A 129 48.816 −44.578 −8.589 1.00 34.45 A C ATOM 1704 CG GLU A 129 47.751 −43.588 −9.137 1.00 47.35 A C ATOM 1707 CD GLU A 129 46.460 −44.250 −9.690 1.00 59.81 A C ATOM 1708 OE1 GLU A 129 45.701 −43.545 −10.403 1.00 60.68 A O ATOM 1709 OE2 GLU A 129 46.191 −45.448 −9.409 1.00 66.05 A O ATOM 1710 C GLU A 129 50.630 −44.910 −6.913 1.00 30.73 A C ATOM 1711 O GLU A 129 51.213 −45.846 −7.455 1.00 30.68 A O ATOM 1713 N VAL A 130 50.610 −44.735 −5.601 1.00 27.24 A N ATOM 1714 CA VAL A 130 51.116 −45.775 −4.718 1.00 26.66 A C ATOM 1716 CB VAL A 130 52.486 −45.414 −4.131 1.00 26.82 A C ATOM 1718 CG1 VAL A 130 53.534 −45.415 −5.233 1.00 26.47 A C ATOM 1722 CG2 VAL A 130 52.439 −44.045 −3.428 1.00 22.87 A C ATOM 1726 C VAL A 130 50.101 −45.976 −3.618 1.00 25.49 A C ATOM 1727 O VAL A 130 49.328 −45.069 −3.314 1.00 23.94 A O ATOM 1729 N SER A 131 50.094 −47.168 −3.035 1.00 25.58 A N ATOM 1730 CA SER A 131 49.112 −47.518 −2.021 1.00 25.94 A C ATOM 1732 CB SER A 131 48.356 −48.780 −2.443 1.00 29.50 A C ATOM 1735 OG SER A 131 47.847 −49.475 −1.304 1.00 28.83 A O ATOM 1737 C SER A 131 49.764 −47.783 −0.707 1.00 23.83 A C ATOM 1738 O SER A 131 50.909 −48.214 −0.668 1.00 24.97 A O ATOM 1740 N GLN A 132 49.015 −47.581 0.375 1.00 24.32 A N ATOM 1741 CA GLN A 132 49.526 −47.858 1.733 1.00 25.61 A C ATOM 1743 CB GLN A 132 48.516 −47.393 2.800 1.00 24.08 A C ATOM 1746 CG GLN A 132 47.161 −48.125 2.806 1.00 27.85 A C ATOM 1749 CD GLN A 132 46.283 −47.760 4.011 1.00 25.79 A C ATOM 1750 OE1 GLN A 132 46.644 −46.918 4.824 1.00 26.01 A O ATOM 1751 NE2 GLN A 132 45.129 −48.398 4.118 1.00 27.24 A N ATOM 1754 C GLN A 132 49.904 −49.353 1.924 1.00 26.55 A C ATOM 1755 O GLN A 132 50.751 −49.702 2.742 1.00 23.45 A O ATOM 1757 N GLU A 133 49.299 −50.236 1.147 1.00 26.74 A N ATOM 1758 CA GLU A 133 49.661 −51.643 1.243 1.00 30.43 A C ATOM 1760 CB GLU A 133 48.627 −52.582 0.584 1.00 31.92 A C ATOM 1763 CG GLU A 133 48.242 −52.326 −0.834 1.00 41.00 A C ATOM 1766 CD GLU A 133 46.890 −52.992 −1.251 1.00 47.38 A C ATOM 1767 OE1 GLU A 133 45.793 −52.388 −1.115 1.00 48.99 A O ATOM 1768 OE2 GLU A 133 46.944 −54.114 −1.767 1.00 48.11 A O ATOM 1769 C GLU A 133 51.104 −51.920 0.816 1.00 30.03 A C ATOM 1770 O GLU A 133 51.634 −52.980 1.099 1.00 30.56 A O ATOM 1772 N ALA A 134 51.779 −50.944 0.220 1.00 30.33 A N ATOM 1773 CA ALA A 134 53.229 −51.050 0.026 1.00 29.74 A C ATOM 1775 CB ALA A 134 53.759 −49.793 −0.603 1.00 28.04 A C ATOM 1779 C ALA A 134 53.976 −51.319 1.333 1.00 30.69 A C ATOM 1780 O ALA A 134 55.073 −51.845 1.323 1.00 31.48 A O ATOM 1782 N PHE A 135 53.377 −50.946 2.454 1.00 31.85 A N ATOM 1783 CA PHE A 135 53.987 −51.134 3.762 1.00 31.97 A C ATOM 1785 CB PHE A 135 53.673 −49.906 4.633 1.00 29.56 A C ATOM 1788 CG PHE A 135 54.296 −48.619 4.122 1.00 28.98 A C ATOM 1789 CD1 PHE A 135 53.549 −47.697 3.402 1.00 24.38 A C ATOM 1791 CE1 PHE A 135 54.120 −46.519 2.916 1.00 21.90 A C ATOM 1793 CZ PHE A 135 55.450 −46.254 3.153 1.00 24.74 A C ATOM 1795 CE2 PHE A 135 56.215 −47.169 3.850 1.00 26.09 A C ATOM 1797 CD2 PHE A 135 55.635 −48.350 4.336 1.00 28.54 A C ATOM 1799 C PHE A 135 53.522 −52.442 4.470 1.00 34.24 A C ATOM 1800 O PHE A 135 53.953 −52.727 5.590 1.00 33.24 A O ATOM 1802 N SER A 136 52.667 −53.235 3.825 1.00 35.02 A N ATOM 1803 CA SER A 136 52.050 −54.394 4.506 1.00 37.80 A C ATOM 1805 CB SER A 136 50.943 −55.039 3.654 1.00 37.47 A C ATOM 1808 OG SER A 136 51.480 −55.711 2.531 1.00 37.80 A O ATOM 1810 C SER A 136 53.065 −55.448 4.966 1.00 38.21 A C ATOM 1811 O SER A 136 52.917 −56.015 6.045 1.00 40.62 A O ATOM 1813 N GLY A 137 54.120 −55.662 4.188 1.00 38.95 A N ATOM 1814 CA GLY A 137 55.167 −56.606 4.562 1.00 38.95 A C ATOM 1817 C GLY A 137 56.057 −56.211 5.738 1.00 39.26 A C ATOM 1818 O GLY A 137 57.001 −56.924 6.045 1.00 39.28 A O ATOM 1820 N PHE A 138 55.770 −55.096 6.405 1.00 39.21 A N ATOM 1821 CA PHE A 138 56.593 −54.643 7.532 1.00 40.53 A C ATOM 1823 CB PHE A 138 57.131 −53.223 7.260 1.00 38.00 A C ATOM 1826 CG PHE A 138 57.991 −53.154 6.039 1.00 34.18 A C ATOM 1827 CD1 PHE A 138 59.251 −53.731 6.040 1.00 34.73 A C ATOM 1829 CE1 PHE A 138 60.049 −53.705 4.893 1.00 34.21 A C ATOM 1831 CZ PHE A 138 59.572 −53.132 3.736 1.00 30.84 A C ATOM 1833 CE2 PHE A 138 58.307 −52.565 3.720 1.00 32.61 A C ATOM 1835 CD2 PHE A 138 57.522 −52.590 4.867 1.00 33.77 A C ATOM 1837 C PHE A 138 55.837 −54.727 8.856 1.00 43.36 A C ATOM 1838 O PHE A 138 56.261 −54.163 9.862 1.00 43.05 A O ATOM 1840 N LYS A 139 54.727 −55.455 8.852 1.00 47.23 A N ATOM 1841 CA LYS A 139 53.884 −55.562 10.029 1.00 51.13 A C ATOM 1843 CB LYS A 139 52.457 −55.086 9.696 1.00 51.78 A C ATOM 1846 CG LYS A 139 52.392 −53.546 9.534 1.00 54.28 A C ATOM 1849 CD LYS A 139 51.184 −53.029 8.748 1.00 61.08 A C ATOM 1852 CE LYS A 139 49.951 −52.824 9.631 1.00 64.23 A C ATOM 1855 NZ LYS A 139 50.121 −51.700 10.603 1.00 59.56 A N ATOM 1859 C LYS A 139 53.964 −56.984 10.582 1.00 53.19 A C ATOM 1860 O LYS A 139 54.306 −57.915 9.856 1.00 54.52 A O ATOM 1862 N ASP A 140 53.715 −57.124 11.886 1.00 55.49 A N ATOM 1863 CA ASP A 140 53.821 −58.410 12.591 1.00 56.32 A C ATOM 1865 CB ASP A 140 54.282 −58.194 14.050 1.00 56.20 A C ATOM 1868 CG ASP A 140 53.262 −57.437 14.902 1.00 53.48 A C ATOM 1869 OD1 ASP A 140 52.109 −57.244 14.468 1.00 47.36 A O ATOM 1870 OD2 ASP A 140 53.627 −57.019 16.016 1.00 50.19 A O ATOM 1871 C ASP A 140 52.503 −59.184 12.535 1.00 58.61 A C ATOM 1872 O ASP A 140 51.591 −58.814 11.787 1.00 57.83 A O ATOM 1874 N GLN A 141 52.409 −60.260 13.321 1.00 61.75 A N ATOM 1875 CA GLN A 141 51.191 −61.083 13.382 1.00 63.46 A C ATOM 1877 CB GLN A 141 51.350 −62.206 14.419 1.00 64.54 A C ATOM 1880 CG GLN A 141 52.401 −63.260 14.080 1.00 67.62 A C ATOM 1883 CD GLN A 141 52.236 −64.534 14.912 1.00 71.72 A C ATOM 1884 OE1 GLN A 141 51.201 −65.200 14.845 1.00 71.94 A O ATOM 1885 NE2 GLN A 141 53.256 −64.873 15.698 1.00 69.09 A N ATOM 1888 C GLN A 141 49.927 −60.264 13.708 1.00 63.18 A C ATOM 1889 O GLN A 141 48.854 −60.539 13.161 1.00 63.42 A O ATOM 1891 N ASN A 142 50.071 −59.265 14.585 1.00 62.04 A N ATOM 1892 CA ASN A 142 48.948 −58.447 15.067 1.00 61.76 A C ATOM 1894 CB ASN A 142 49.211 −58.041 16.521 1.00 62.74 A C ATOM 1897 CG ASN A 142 49.124 −59.216 17.476 1.00 64.28 A C ATOM 1898 OD1 ASN A 142 48.147 −59.967 17.461 1.00 65.28 A O ATOM 1899 ND2 ASN A 142 50.143 −59.379 18.314 1.00 61.18 A N ATOM 1902 C ASN A 142 48.609 −57.182 14.259 1.00 60.73 A C ATOM 1903 O ASN A 142 47.790 −56.374 14.696 1.00 60.76 A O ATOM 1905 N GLY A 143 49.223 −57.006 13.094 1.00 58.94 A N ATOM 1906 CA GLY A 143 48.969 −55.823 12.273 1.00 58.11 A C ATOM 1909 C GLY A 143 49.577 −54.533 12.818 1.00 56.81 A C ATOM 1910 O GLY A 143 49.040 −53.451 12.596 1.00 56.75 A O ATOM 1912 N ASN A 144 50.684 −54.658 13.551 1.00 54.34 A N ATOM 1913 CA ASN A 144 51.452 −53.517 14.036 1.00 51.31 A C ATOM 1915 CB ASN A 144 51.523 −53.532 15.561 1.00 50.99 A C ATOM 1918 CG ASN A 144 50.156 −53.394 16.203 1.00 54.98 A C ATOM 1919 OD1 ASN A 144 49.390 −52.496 15.861 1.00 57.50 A O ATOM 1920 ND2 ASN A 144 49.836 −54.291 17.129 1.00 54.41 A N ATOM 1923 C ASN A 144 52.842 −53.594 13.421 1.00 47.91 A C ATOM 1924 O ASN A 144 53.314 −54.678 13.096 1.00 45.74 A O ATOM 1926 N PHE A 145 53.487 −52.450 13.225 1.00 45.60 A N ATOM 1927 CA PHE A 145 54.827 −52.432 12.636 1.00 42.79 A C ATOM 1929 CB PHE A 145 55.315 −50.995 12.429 1.00 41.21 A C ATOM 1932 CG PHE A 145 54.767 −50.342 11.190 1.00 34.59 A C ATOM 1933 CD1 PHE A 145 53.612 −49.583 11.241 1.00 28.50 A C ATOM 1935 CE1 PHE A 145 53.097 −48.999 10.107 1.00 33.37 A C ATOM 1937 CZ PHE A 145 53.749 −49.159 8.890 1.00 34.40 A C ATOM 1939 CE2 PHE A 145 54.909 −49.912 8.827 1.00 36.36 A C ATOM 1941 CD2 PHE A 145 55.403 −50.508 9.971 1.00 33.35 A C ATOM 1943 C PHE A 145 55.811 −53.220 13.509 1.00 43.43 A C ATOM 1944 O PHE A 145 55.739 −53.168 14.740 1.00 39.77 A O ATOM 1946 N LEU A 146 56.719 −53.949 12.862 1.00 45.03 A N ATOM 1947 CA LEU A 146 57.658 −54.811 13.574 1.00 47.52 A C ATOM 1949 CB LEU A 146 58.571 −55.562 12.600 1.00 48.77 A C ATOM 1952 CG LEU A 146 57.939 −56.744 11.854 1.00 51.30 A C ATOM 1954 CD1 LEU A 146 58.802 −57.157 10.656 1.00 53.93 A C ATOM 1958 CD2 LEU A 146 57.724 −57.920 12.803 1.00 50.78 A C ATOM 1962 C LEU A 146 58.503 −53.994 14.521 1.00 47.29 A C ATOM 1963 O LEU A 146 59.085 −53.004 14.122 1.00 46.58 A O ATOM 1965 N GLU A 147 58.546 −54.418 15.778 1.00 48.15 A N ATOM 1966 CA GLU A 147 59.333 −53.766 16.818 1.00 49.25 A C ATOM 1968 CB GLU A 147 59.243 −54.591 18.121 1.00 51.28 A C ATOM 1971 CG GLU A 147 59.923 −53.979 19.359 1.00 56.00 A C ATOM 1974 CD GLU A 147 59.228 −52.725 19.877 1.00 63.07 A C ATOM 1975 OE1 GLU A 147 58.125 −52.395 19.387 1.00 66.00 A O ATOM 1976 OE2 GLU A 147 59.788 −52.068 20.785 1.00 66.72 A O ATOM 1977 C GLU A 147 60.791 −53.608 16.404 1.00 47.26 A C ATOM 1978 O GLU A 147 61.365 −52.554 16.584 1.00 46.13 A O ATOM 1980 N ASN A 148 61.383 −54.649 15.830 1.00 47.30 A N ATOM 1981 CA ASN A 148 62.824 −54.639 15.564 1.00 48.47 A C ATOM 1983 CB ASN A 148 63.333 −56.046 15.259 1.00 49.35 A C ATOM 1986 CG ASN A 148 62.710 −56.636 14.014 1.00 55.86 A C ATOM 1987 OD1 ASN A 148 62.358 −55.913 13.075 1.00 62.15 A O ATOM 1988 ND2 ASN A 148 62.566 −57.959 13.994 1.00 57.68 A N ATOM 1991 C ASN A 148 63.268 −53.665 14.470 1.00 48.40 A C ATOM 1992 O ASN A 148 64.470 −53.493 14.255 1.00 48.76 A O ATOM 1994 N LEU A 149 62.308 −53.037 13.781 1.00 47.17 A N ATOM 1995 CA LEU A 149 62.612 −52.012 12.775 1.00 45.22 A C ATOM 1997 CB LEU A 149 61.391 −51.719 11.883 1.00 44.21 A C ATOM 2000 CG LEU A 149 60.901 −52.874 10.985 1.00 45.00 A C ATOM 2002 CD1 LEU A 149 59.457 −52.641 10.487 1.00 35.64 A C ATOM 2006 CD2 LEU A 149 61.859 −53.134 9.818 1.00 40.71 A C ATOM 2010 C LEU A 149 63.119 −50.719 13.427 1.00 44.14 A C ATOM 2011 O LEU A 149 63.767 −49.915 12.767 1.00 43.38 A O ATOM 2013 N LYS A 150 62.848 −50.535 14.723 1.00 43.89 A N ATOM 2014 CA LYS A 150 63.299 −49.345 15.459 1.00 43.64 A C ATOM 2016 CB LYS A 150 62.834 −49.395 16.921 1.00 44.18 A C ATOM 2019 CG LYS A 150 63.567 −50.438 17.776 1.00 45.80 A C ATOM 2022 CD LYS A 150 62.990 −50.566 19.179 1.00 46.45 A C ATOM 2025 CE LYS A 150 63.602 −51.772 19.932 1.00 46.45 A C ATOM 2028 NZ LYS A 150 63.600 −51.578 21.410 1.00 44.46 A N ATOM 2032 C LYS A 150 64.816 −49.166 15.418 1.00 43.28 A C ATOM 2033 O LYS A 150 65.307 −48.058 15.547 1.00 43.46 A O ATOM 2035 N GLU A 151 65.548 −50.262 15.231 1.00 43.96 A N ATOM 2036 CA GLU A 151 67.016 −50.229 15.193 1.00 44.86 A C ATOM 2038 CB GLU A 151 67.590 −51.660 15.231 1.00 46.17 A C ATOM 2041 CG GLU A 151 67.109 −52.575 16.391 1.00 48.12 A C ATOM 2044 CD GLU A 151 67.468 −52.062 17.783 1.00 57.25 A C ATOM 2045 OE1 GLU A 151 68.205 −51.057 17.895 1.00 58.32 A O ATOM 2046 OE2 GLU A 151 67.010 −52.679 18.776 1.00 64.54 A O ATOM 2047 C GLU A 151 67.568 −49.510 13.960 1.00 44.01 A C ATOM 2048 O GLU A 151 68.687 −49.009 13.987 1.00 45.27 A O ATOM 2050 N ASP A 152 66.778 −49.481 12.887 1.00 43.54 A N ATOM 2051 CA ASP A 152 67.182 −48.939 11.586 1.00 42.81 A C ATOM 2053 CB ASP A 152 66.628 −49.846 10.469 1.00 42.48 A C ATOM 2056 CG ASP A 152 67.076 −49.431 9.065 1.00 44.12 A C ATOM 2057 OD1 ASP A 152 67.707 −48.356 8.890 1.00 44.74 A O ATOM 2058 OD2 ASP A 152 66.785 −50.208 8.122 1.00 43.55 A O ATOM 2059 C ASP A 152 66.619 −47.524 11.481 1.00 41.46 A C ATOM 2060 O ASP A 152 65.557 −47.307 10.902 1.00 41.35 A O ATOM 2062 N ILE A 153 67.345 −46.569 12.045 1.00 39.78 A N ATOM 2063 CA ILE A 153 66.816 −45.228 12.270 1.00 39.72 A C ATOM 2065 CB ILE A 153 67.695 −44.468 13.244 1.00 40.91 A C ATOM 2067 CG1 ILE A 153 67.578 −45.131 14.627 1.00 43.16 A C ATOM 2070 CD1 ILE A 153 68.849 −45.081 15.411 1.00 50.21 A C ATOM 2074 CG2 ILE A 153 67.288 −42.997 13.309 1.00 36.49 A C ATOM 2078 C ILE A 153 66.625 −44.422 10.992 1.00 39.38 A C ATOM 2079 O ILE A 153 65.718 −43.606 10.902 1.00 38.41 A O ATOM 2081 N LYS A 154 67.483 −44.667 10.011 1.00 38.77 A N ATOM 2082 CA LYS A 154 67.316 −44.131 8.675 1.00 38.08 A C ATOM 2084 CB LYS A 154 68.439 −44.657 7.771 1.00 39.94 A C ATOM 2087 CG LYS A 154 69.030 −43.679 6.791 1.00 46.34 A C ATOM 2090 CD LYS A 154 69.998 −44.418 5.833 1.00 57.75 A C ATOM 2093 CE LYS A 154 71.163 −43.526 5.362 1.00 63.86 A C ATOM 2096 NZ LYS A 154 72.090 −43.113 6.477 1.00 66.28 A N ATOM 2100 C LYS A 154 65.966 −44.582 8.123 1.00 34.45 A C ATOM 2101 O LYS A 154 65.265 −43.806 7.491 1.00 34.91 A O ATOM 2103 N ALA A 155 65.602 −45.841 8.360 1.00 31.65 A N ATOM 2104 CA ALA A 155 64.367 −46.382 7.796 1.00 29.70 A C ATOM 2106 CB ALA A 155 64.349 −47.881 7.905 1.00 28.03 A C ATOM 2110 C ALA A 155 63.147 −45.772 8.484 1.00 29.53 A C ATOM 2111 O ALA A 155 62.118 −45.546 7.862 1.00 28.76 A O ATOM 2113 N ILE A 156 63.291 −45.483 9.769 1.00 28.30 A N ATOM 2114 CA ILE A 156 62.218 −44.941 10.574 1.00 29.28 A C ATOM 2116 CB ILE A 156 62.573 −45.035 12.062 1.00 30.53 A C ATOM 2118 CG1 ILE A 156 62.606 −46.500 12.498 1.00 32.30 A C ATOM 2121 CD1 ILE A 156 61.294 −47.182 12.411 1.00 34.89 A C ATOM 2125 CG2 ILE A 156 61.599 −44.209 12.894 1.00 35.42 A C ATOM 2129 C ILE A 156 61.957 −43.486 10.232 1.00 26.18 A C ATOM 2130 O ILE A 156 60.816 −43.061 10.146 1.00 25.91 A O ATOM 2132 N LEU A 157 63.026 −42.738 10.049 1.00 25.45 A N ATOM 2133 CA LEU A 157 62.941 −41.363 9.595 1.00 27.66 A C ATOM 2135 CB LEU A 157 64.320 −40.773 9.381 1.00 28.15 A C ATOM 2138 CG LEU A 157 64.937 −39.982 10.520 1.00 34.36 A C ATOM 2140 CD1 LEU A 157 66.210 −39.356 9.983 1.00 31.72 A C ATOM 2144 CD2 LEU A 157 63.996 −38.917 11.050 1.00 32.16 A C ATOM 2148 C LEU A 157 62.215 −41.330 8.271 1.00 27.68 A C ATOM 2149 O LEU A 157 61.279 −40.551 8.073 1.00 26.10 A O ATOM 2151 N SER A 158 62.658 −42.199 7.371 1.00 26.74 A N ATOM 2152 CA SER A 158 62.074 −42.255 6.064 1.00 27.94 A C ATOM 2154 CB SER A 158 62.861 −43.219 5.198 1.00 27.98 A C ATOM 2157 OG SER A 158 62.518 −43.042 3.845 1.00 44.57 A O ATOM 2159 C SER A 158 60.573 −42.600 6.186 1.00 25.94 A C ATOM 2160 O SER A 158 59.730 −41.938 5.574 1.00 23.44 A O ATOM 2162 N LEU A 159 60.227 −43.568 7.034 1.00 24.38 A N ATOM 2163 CA LEU A 159 58.807 −43.865 7.292 1.00 23.67 A C ATOM 2165 CB LEU A 159 58.667 −45.082 8.206 1.00 23.04 A C ATOM 2168 CG LEU A 159 57.261 −45.601 8.496 1.00 23.72 A C ATOM 2170 CD1 LEU A 159 56.577 −46.056 7.202 1.00 19.76 A C ATOM 2174 CD2 LEU A 159 57.295 −46.735 9.527 1.00 24.23 A C ATOM 2178 C LEU A 159 58.065 −42.651 7.881 1.00 22.73 A C ATOM 2179 O LEU A 159 56.955 −42.353 7.468 1.00 25.33 A O ATOM 2181 N TYR A 160 58.676 −41.950 8.834 1.00 21.28 A N ATOM 2182 CA TYR A 160 58.069 −40.740 9.406 1.00 19.99 A C ATOM 2184 CB TYR A 160 58.966 −40.158 10.499 1.00 16.21 A C ATOM 2187 CG TYR A 160 58.612 −38.765 11.028 1.00 15.97 A C ATOM 2188 CD1 TYR A 160 57.726 −38.581 12.074 1.00 20.63 A C ATOM 2190 CE1 TYR A 160 57.431 −37.309 12.550 1.00 23.21 A C ATOM 2192 CZ TYR A 160 58.069 −36.229 12.008 1.00 24.75 A C ATOM 2193 OH TYR A 160 57.813 −34.949 12.441 1.00 37.71 A O ATOM 2195 CE2 TYR A 160 58.962 −36.401 10.988 1.00 27.54 A C ATOM 2197 CD2 TYR A 160 59.228 −37.648 10.513 1.00 27.04 A C ATOM 2199 C TYR A 160 57.758 −39.715 8.301 1.00 20.86 A C ATOM 2200 O TYR A 160 56.670 −39.148 8.261 1.00 19.44 A O ATOM 2202 N GLU A 161 58.691 −39.529 7.376 1.00 22.74 A N ATOM 2203 CA GLU A 161 58.562 −38.479 6.366 1.00 22.29 A C ATOM 2205 CB GLU A 161 59.869 −38.239 5.586 1.00 22.32 A C ATOM 2208 CG GLU A 161 61.065 −37.781 6.403 1.00 25.25 A C ATOM 2211 CD GLU A 161 60.985 −36.329 6.883 1.00 29.78 A C ATOM 2212 OE1 GLU A 161 59.985 −35.612 6.600 1.00 30.17 A O ATOM 2213 OE2 GLU A 161 61.934 −35.925 7.588 1.00 23.68 A O ATOM 2214 C GLU A 161 57.477 −38.855 5.384 1.00 23.03 A C ATOM 2215 O GLU A 161 56.726 −37.983 4.954 1.00 23.28 A O ATOM 2217 N ALA A 162 57.404 −40.139 5.031 1.00 19.57 A N ATOM 2218 CA ALA A 162 56.377 −40.621 4.113 1.00 20.19 A C ATOM 2220 CB ALA A 162 56.619 −42.067 3.743 1.00 17.81 A C ATOM 2224 C ALA A 162 54.968 −40.459 4.674 1.00 20.85 A C ATOM 2225 O ALA A 162 54.042 −40.179 3.921 1.00 20.56 A O ATOM 2227 N SER A 163 54.795 −40.651 5.983 1.00 21.00 A N ATOM 2228 CA SER A 163 53.453 −40.617 6.584 1.00 20.15 A C ATOM 2230 CB SER A 163 53.512 −40.917 8.077 1.00 20.26 A C ATOM 2233 OG SER A 163 54.223 −39.914 8.772 1.00 22.70 A O ATOM 2235 C SER A 163 52.758 −39.276 6.398 1.00 20.14 A C ATOM 2236 O SER A 163 51.553 −39.212 6.412 1.00 21.29 A O ATOM 2238 N PHE A 164 53.505 −38.194 6.207 1.00 21.91 A N ATOM 2239 CA PHE A 164 52.852 −36.893 6.012 1.00 21.51 A C ATOM 2241 CB PHE A 164 53.783 −35.742 6.353 1.00 21.26 A C ATOM 2244 CG PHE A 164 54.107 −35.680 7.823 1.00 20.56 A C ATOM 2245 CD1 PHE A 164 53.300 −34.984 8.692 1.00 19.82 A C ATOM 2247 CE1 PHE A 164 53.593 −34.950 10.044 1.00 20.99 A C ATOM 2249 CZ PHE A 164 54.694 −35.621 10.537 1.00 19.87 A C ATOM 2251 CE2 PHE A 164 55.491 −36.343 9.683 1.00 22.05 A C ATOM 2253 CD2 PHE A 164 55.178 −36.390 8.335 1.00 19.04 A C ATOM 2255 C PHE A 164 52.235 −36.724 4.651 1.00 20.83 A C ATOM 2256 O PHE A 164 51.564 −35.732 4.420 1.00 20.53 A O ATOM 2258 N LEU A 165 52.434 −37.694 3.759 1.00 21.43 A N ATOM 2259 CA LEU A 165 51.817 −37.634 2.443 1.00 21.34 A C ATOM 2261 CB LEU A 165 52.808 −38.064 1.356 1.00 21.77 A C ATOM 2264 CG LEU A 165 53.927 −37.066 0.985 1.00 24.00 A C ATOM 2266 CD1 LEU A 165 55.125 −37.119 1.950 1.00 24.11 A C ATOM 2270 CD2 LEU A 165 54.414 −37.300 −0.424 1.00 21.22 A C ATOM 2274 C LEU A 165 50.496 −38.420 2.372 1.00 21.79 A C ATOM 2275 O LEU A 165 49.967 −38.657 1.306 1.00 24.21 A O ATOM 2277 N ALA A 166 49.957 −38.775 3.523 1.00 21.05 A N ATOM 2278 CA ALA A 166 48.760 −39.562 3.627 1.00 21.13 A C ATOM 2280 CB ALA A 166 48.449 −39.848 5.112 1.00 16.14 A C ATOM 2284 C ALA A 166 47.564 −38.887 2.998 1.00 22.34 A C ATOM 2285 O ALA A 166 47.448 −37.664 3.031 1.00 23.04 A O ATOM 2287 N LEU A 167 46.670 −39.710 2.446 1.00 22.65 A N ATOM 2288 CA LEU A 167 45.315 −39.299 2.123 1.00 22.73 A C ATOM 2290 CB LEU A 167 44.903 −39.929 0.805 1.00 22.79 A C ATOM 2293 CG LEU A 167 45.870 −39.733 −0.367 1.00 29.42 A C ATOM 2295 CD1 LEU A 167 45.269 −40.327 −1.669 1.00 17.64 A C ATOM 2299 CD2 LEU A 167 46.250 −38.249 −0.540 1.00 18.14 A C ATOM 2303 C LEU A 167 44.351 −39.758 3.235 1.00 23.82 A C ATOM 2304 O LEU A 167 44.694 −40.592 4.059 1.00 22.47 A O ATOM 2306 N GLU A 168 43.139 −39.228 3.239 1.00 24.07 A N ATOM 2307 CA GLU A 168 42.132 −39.692 4.157 1.00 25.29 A C ATOM 2309 CB GLU A 168 40.818 −38.931 3.943 1.00 27.27 A C ATOM 2312 CG GLU A 168 40.738 −37.525 4.576 1.00 30.92 A C ATOM 2315 CD GLU A 168 39.356 −36.894 4.371 1.00 38.89 A C ATOM 2316 OE1 GLU A 168 38.996 −36.617 3.199 1.00 36.18 A O ATOM 2317 OE2 GLU A 168 38.626 −36.700 5.379 1.00 42.80 A O ATOM 2318 C GLU A 168 41.902 −41.186 3.935 1.00 25.25 A C ATOM 2319 O GLU A 168 41.855 −41.652 2.798 1.00 22.24 A O ATOM 2321 N GLY A 169 41.748 −41.928 5.034 1.00 24.73 A N ATOM 2322 CA GLY A 169 41.540 −43.370 4.977 1.00 21.86 A C ATOM 2325 C GLY A 169 42.785 −44.213 5.048 1.00 21.58 A C ATOM 2326 O GLY A 169 42.692 −45.426 5.190 1.00 24.46 A O ATOM 2328 N GLU A 170 43.956 −43.598 4.967 1.00 20.95 A N ATOM 2329 CA GLU A 170 45.179 −44.378 4.872 1.00 21.33 A C ATOM 2331 CB GLU A 170 46.219 −43.717 3.960 1.00 16.76 A C ATOM 2334 CG GLU A 170 45.778 −43.588 2.518 1.00 22.22 A C ATOM 2337 CD GLU A 170 46.915 −43.209 1.542 1.00 28.05 A C ATOM 2338 OE1 GLU A 170 47.070 −43.885 0.497 1.00 32.07 A O ATOM 2339 OE2 GLU A 170 47.654 −42.242 1.822 1.00 24.57 A O ATOM 2340 C GLU A 170 45.699 −44.577 6.271 1.00 21.42 A C ATOM 2341 O GLU A 170 46.699 −43.979 6.686 1.00 21.14 A O ATOM 2343 N ASN A 171 45.000 −45.435 6.992 1.00 21.46 A N ATOM 2344 CA ASN A 171 45.247 −45.636 8.406 1.00 23.53 A C ATOM 2346 CB ASN A 171 44.197 −46.587 8.999 1.00 24.69 A C ATOM 2349 CG ASN A 171 44.256 −47.982 8.375 1.00 28.66 A C ATOM 2350 OD1 ASN A 171 43.992 −48.155 7.177 1.00 21.35 A O ATOM 2351 ND2 ASN A 171 44.645 −48.972 9.178 1.00 19.68 A N ATOM 2354 C ASN A 171 46.648 −46.164 8.692 1.00 24.20 A C ATOM 2355 O ASN A 171 47.193 −45.894 9.753 1.00 24.52 A O ATOM 2357 N ILE A 172 47.217 −46.909 7.745 1.00 25.20 A N ATOM 2358 CA ILE A 172 48.549 −47.478 7.893 1.00 27.16 A C ATOM 2360 CB ILE A 172 48.898 −48.455 6.738 1.00 27.07 A C ATOM 2362 CG1 ILE A 172 47.981 −49.677 6.764 1.00 30.96 A C ATOM 2365 CD1 ILE A 172 48.252 −50.653 5.616 1.00 34.90 A C ATOM 2369 CG2 ILE A 172 50.354 −48.935 6.825 1.00 23.91 A C ATOM 2373 C ILE A 172 49.595 −46.348 8.004 1.00 28.36 A C ATOM 2374 O ILE A 172 50.534 −46.443 8.787 1.00 29.81 A O ATOM 2376 N LEU A 173 49.393 −45.268 7.264 1.00 27.42 A N ATOM 2377 CA LEU A 173 50.326 −44.141 7.300 1.00 27.76 A C ATOM 2379 CB LEU A 173 50.138 −43.217 6.096 1.00 27.01 A C ATOM 2382 CG LEU A 173 50.933 −43.554 4.842 1.00 27.25 A C ATOM 2384 CD1 LEU A 173 50.747 −44.951 4.446 1.00 27.88 A C ATOM 2388 CD2 LEU A 173 50.482 −42.633 3.687 1.00 29.35 A C ATOM 2392 C LEU A 173 50.197 −43.362 8.605 1.00 26.43 A C ATOM 2393 O LEU A 173 51.201 −42.925 9.141 1.00 25.15 A O ATOM 2395 N ASP A 174 48.981 −43.205 9.121 1.00 24.34 A N ATOM 2396 CA ASP A 174 48.792 −42.610 10.443 1.00 26.66 A C ATOM 2398 CB ASP A 174 47.310 −42.444 10.771 1.00 27.51 A C ATOM 2401 CG ASP A 174 46.649 −41.327 9.959 1.00 34.04 A C ATOM 2402 OD1 ASP A 174 47.363 −40.551 9.305 1.00 40.90 A O ATOM 2403 OD2 ASP A 174 45.406 −41.228 9.980 1.00 42.95 A O ATOM 2404 C ASP A 174 49.438 −43.451 11.539 1.00 27.18 A C ATOM 2405 O ASP A 174 50.099 −42.926 12.432 1.00 28.53 A O ATOM 2407 N GLU A 175 49.228 −44.756 11.480 1.00 28.79 A N ATOM 2408 CA GLU A 175 49.843 −45.659 12.431 1.00 29.42 A C ATOM 2410 CB GLU A 175 49.321 −47.083 12.237 1.00 29.10 A C ATOM 2413 CG GLU A 175 47.835 −47.244 12.560 1.00 36.91 A C ATOM 2416 CD GLU A 175 47.189 −48.421 11.819 1.00 41.63 A C ATOM 2417 OE1 GLU A 175 47.928 −49.311 11.327 1.00 42.73 A O ATOM 2418 OE2 GLU A 175 45.946 −48.436 11.719 1.00 39.01 A O ATOM 2419 C GLU A 175 51.356 −45.616 12.230 1.00 27.89 A C ATOM 2420 O GLU A 175 52.100 −45.726 13.180 1.00 27.43 A O ATOM 2422 N ALA A 176 51.797 −45.473 10.982 1.00 27.66 A N ATOM 2423 CA ALA A 176 53.225 −45.370 10.668 1.00 28.24 A C ATOM 2425 CB ALA A 176 53.428 −45.280 9.153 1.00 26.14 A C ATOM 2429 C ALA A 176 53.872 −44.173 11.387 1.00 27.46 A C ATOM 2430 O ALA A 176 54.970 −44.276 11.929 1.00 27.53 A O ATOM 2432 N LYS A 177 53.155 −43.055 11.418 1.00 26.90 A N ATOM 2433 CA LYS A 177 53.626 −41.840 12.060 1.00 27.36 A C ATOM 2435 CB LYS A 177 52.670 −40.666 11.775 1.00 26.52 A C ATOM 2438 CG LYS A 177 53.138 −39.310 12.294 1.00 26.21 A C ATOM 2441 CD LYS A 177 52.073 −38.200 12.199 1.00 27.44 A C ATOM 2444 CE LYS A 177 51.689 −37.893 10.754 1.00 28.20 A C ATOM 2447 NZ LYS A 177 50.565 −36.898 10.663 1.00 27.57 A N ATOM 2451 C LYS A 177 53.783 −42.067 13.558 1.00 28.77 A C ATOM 2452 O LYS A 177 54.830 −41.743 14.117 1.00 28.26 A O ATOM 2454 N VAL A 178 52.749 −42.617 14.196 1.00 29.28 A N ATOM 2455 CA VAL A 178 52.737 −42.855 15.654 1.00 27.74 A C ATOM 2457 CB VAL A 178 51.409 −43.524 16.103 1.00 28.79 A C ATOM 2459 CG1 VAL A 178 51.481 −44.089 17.585 1.00 22.40 A C ATOM 2463 CG2 VAL A 178 50.228 −42.565 15.919 1.00 23.47 A C ATOM 2467 C VAL A 178 53.907 −43.758 16.025 1.00 29.18 A C ATOM 2468 O VAL A 178 54.651 −43.485 16.955 1.00 30.11 A O ATOM 2470 N PHE A 179 54.058 −44.838 15.273 1.00 28.49 A N ATOM 2471 CA PHE A 179 55.168 −45.759 15.448 1.00 28.24 A C ATOM 2473 CB PHE A 179 54.990 −46.915 14.466 1.00 28.43 A C ATOM 2476 CG PHE A 179 56.115 −47.880 14.457 1.00 29.30 A C ATOM 2477 CD1 PHE A 179 56.233 −48.824 15.453 1.00 30.81 A C ATOM 2479 CE1 PHE A 179 57.278 −49.725 15.441 1.00 28.19 A C ATOM 2481 CZ PHE A 179 58.208 −49.687 14.431 1.00 30.08 A C ATOM 2483 CE2 PHE A 179 58.089 −48.755 13.424 1.00 30.12 A C ATOM 2485 CD2 PHE A 179 57.051 −47.860 13.444 1.00 29.06 A C ATOM 2487 C PHE A 179 56.555 −45.097 15.276 1.00 28.33 A C ATOM 2488 O PHE A 179 57.435 −45.283 16.104 1.00 25.10 A O ATOM 2490 N ALA A 180 56.757 −44.332 14.204 1.00 28.10 A N ATOM 2491 CA ALA A 180 58.054 −43.728 13.971 1.00 26.76 A C ATOM 2493 CB ALA A 180 58.150 −43.168 12.577 1.00 24.69 A C ATOM 2497 C ALA A 180 58.382 −42.652 15.034 1.00 29.09 A C ATOM 2498 O ALA A 180 59.485 −42.646 15.586 1.00 27.52 A O ATOM 2500 N ILE A 181 57.420 −41.775 15.319 1.00 28.79 A N ATOM 2501 CA ILE A 181 57.591 −40.717 16.285 1.00 30.81 A C ATOM 2503 CB ILE A 181 56.310 −39.865 16.483 1.00 31.36 A C ATOM 2505 CG1 ILE A 181 56.105 −38.909 15.302 1.00 38.18 A C ATOM 2508 CD1 ILE A 181 54.765 −38.081 15.352 1.00 37.32 A C ATOM 2512 CG2 ILE A 181 56.415 −39.000 17.738 1.00 34.50 A C ATOM 2516 C ILE A 181 58.002 −41.293 17.629 1.00 33.92 A C ATOM 2517 O ILE A 181 58.908 −40.757 18.270 1.00 32.34 A O ATOM 2519 N SER A 182 57.359 −42.383 18.045 1.00 34.21 A N ATOM 2520 CA SER A 182 57.608 −42.923 19.361 1.00 37.21 A C ATOM 2522 CB SER A 182 56.573 −43.991 19.721 1.00 37.94 A C ATOM 2525 OG SER A 182 56.744 −45.180 18.958 1.00 41.64 A O ATOM 2527 C SER A 182 59.030 −43.474 19.473 1.00 38.60 A C ATOM 2528 O SER A 182 59.618 −43.437 20.553 1.00 40.23 A O ATOM 2530 N HIS A 183 59.570 −43.982 18.366 1.00 38.90 A N ATOM 2531 CA HIS A 183 60.933 −44.519 18.342 1.00 40.39 A C ATOM 2533 CB HIS A 183 61.054 −45.715 17.401 1.00 39.71 A C ATOM 2536 CG HIS A 183 60.270 −46.913 17.839 1.00 46.09 A C ATOM 2537 ND1 HIS A 183 60.409 −47.479 19.089 1.00 52.45 A N ATOM 2539 CE1 HIS A 183 59.597 −48.516 19.192 1.00 55.12 A C ATOM 2541 NE2 HIS A 183 58.945 −48.648 18.051 1.00 54.77 A N ATOM 2543 CD2 HIS A 183 59.349 −47.660 17.188 1.00 47.51 A C ATOM 2545 C HIS A 183 61.972 −43.469 17.945 1.00 41.16 A C ATOM 2546 O HIS A 183 63.162 −43.724 18.087 1.00 44.04 A O ATOM 2548 N LEU A 184 61.536 −42.314 17.439 1.00 38.00 A N ATOM 2549 CA LEU A 184 62.448 −41.207 17.193 1.00 37.65 A C ATOM 2551 CB LEU A 184 62.018 −40.400 15.968 1.00 34.76 A C ATOM 2554 CG LEU A 184 62.130 −41.133 14.624 1.00 35.32 A C ATOM 2556 CD1 LEU A 184 61.311 −40.390 13.576 1.00 22.44 A C ATOM 2560 CD2 LEU A 184 63.579 −41.297 14.167 1.00 24.78 A C ATOM 2564 C LEU A 184 62.591 −40.267 18.400 1.00 37.45 A C ATOM 2565 O LEU A 184 63.620 −39.647 18.551 1.00 33.63 A O ATOM 2567 N LYS A 185 61.558 −40.165 19.231 1.00 40.96 A N ATOM 2568 CA LYS A 185 61.490 −39.158 20.286 1.00 46.25 A C ATOM 2570 CB LYS A 185 60.062 −39.043 20.825 1.00 47.18 A C ATOM 2573 CG LYS A 185 59.568 −37.619 20.940 1.00 54.79 A C ATOM 2576 CD LYS A 185 58.037 −37.534 21.071 1.00 62.29 A C ATOM 2579 CE LYS A 185 57.489 −36.307 20.328 1.00 65.20 A C ATOM 2582 NZ LYS A 185 56.019 −36.110 20.508 1.00 64.22 A N ATOM 2586 C LYS A 185 62.412 −39.502 21.447 1.00 50.17 A C ATOM 2587 O LYS A 185 62.835 −38.626 22.190 1.00 50.48 A O ATOM 2589 N GLU A 186 62.695 −40.786 21.608 1.00 54.79 A N ATOM 2590 CA GLU A 186 63.492 −41.268 22.714 1.00 59.57 A C ATOM 2592 CB GLU A 186 62.748 −42.417 23.422 1.00 61.31 A C ATOM 2595 CG GLU A 186 61.324 −42.053 23.918 1.00 65.37 A C ATOM 2598 CD GLU A 186 61.289 −40.817 24.837 1.00 71.20 A C ATOM 2599 OE1 GLU A 186 62.279 −40.570 25.570 1.00 72.40 A O ATOM 2600 OE2 GLU A 186 60.266 −40.090 24.826 1.00 69.58 A O ATOM 2601 C GLU A 186 64.859 −41.715 22.199 1.00 61.26 A C ATOM 2602 O GLU A 186 65.344 −42.800 22.545 1.00 61.31 A O ATOM 2604 N LEU A 187 65.474 −40.871 21.368 1.00 61.95 A N ATOM 2605 CA LEU A 187 66.803 −41.144 20.832 1.00 62.48 A C ATOM 2607 CB LEU A 187 66.795 −41.069 19.309 1.00 61.46 A C ATOM 2610 CG LEU A 187 66.046 −42.207 18.622 1.00 60.67 A C ATOM 2612 CD1 LEU A 187 66.159 −42.112 17.107 1.00 54.64 A C ATOM 2616 CD2 LEU A 187 66.571 −43.549 19.105 1.00 60.19 A C ATOM 2620 C LEU A 187 67.848 −40.185 21.403 1.00 64.11 A C ATOM 2621 O LEU A 187 67.646 −38.964 21.436 1.00 63.36 A O ATOM 2623 N SER A 188 68.968 −40.764 21.842 1.00 66.14 A N ATOM 2624 CA SER A 188 70.064 −40.014 22.460 1.00 66.96 A C ATOM 2626 CB SER A 188 70.591 −40.762 23.685 1.00 67.57 A C ATOM 2629 OG SER A 188 69.575 −40.923 24.660 1.00 70.39 A O ATOM 2631 C SER A 188 71.203 −39.809 21.472 1.00 66.59 A C ATOM 2632 O SER A 188 71.607 −40.744 20.766 1.00 64.52 A O ATOM 2634 N GLU A 189 71.720 −38.583 21.438 1.00 67.77 A N ATOM 2635 CA GLU A 189 72.847 −38.231 20.578 1.00 69.56 A C ATOM 2637 CB GLU A 189 73.248 −36.765 20.791 1.00 70.17 A C ATOM 2640 CG GLU A 189 74.339 −36.266 19.841 1.00 73.91 A C ATOM 2643 CD GLU A 189 74.480 −34.742 19.820 1.00 79.04 A C ATOM 2644 OE1 GLU A 189 73.752 −34.043 20.565 1.00 78.69 A O ATOM 2645 OE2 GLU A 189 75.329 −34.244 19.044 1.00 81.94 A O ATOM 2646 C GLU A 189 74.039 −39.156 20.818 1.00 70.07 A C ATOM 2647 O GLU A 189 74.733 −39.517 19.875 1.00 68.55 A O ATOM 2649 N GLU A 190 74.260 −39.536 22.078 1.00 71.69 A N ATOM 2650 CA GLU A 190 75.327 −40.477 22.448 1.00 72.75 A C ATOM 2652 CB GLU A 190 75.285 −40.796 23.952 1.00 73.95 A C ATOM 2655 CG GLU A 190 76.108 −39.856 24.832 1.00 77.12 A C ATOM 2658 CD GLU A 190 75.626 −38.415 24.801 1.00 81.42 A C ATOM 2659 OE1 GLU A 190 74.514 −38.146 24.284 1.00 82.03 A O ATOM 2660 OE2 GLU A 190 76.372 −37.546 25.303 1.00 83.94 A O ATOM 2661 C GLU A 190 75.242 −41.777 21.654 1.00 72.09 A C ATOM 2662 O GLU A 190 76.225 −42.207 21.051 1.00 72.00 A O ATOM 2664 N LYS A 191 74.058 −42.384 21.648 1.00 71.50 A N ATOM 2665 CA LYS A 191 73.837 −43.669 20.977 1.00 71.87 A C ATOM 2667 CB LYS A 191 72.406 −44.167 21.222 1.00 72.85 A C ATOM 2670 CG LYS A 191 71.999 −44.262 22.685 1.00 77.73 A C ATOM 2673 CD LYS A 191 72.705 −45.417 23.395 1.00 84.01 A C ATOM 2676 CE LYS A 191 72.961 −45.117 24.873 1.00 85.51 A C ATOM 2679 NZ LYS A 191 74.197 −45.799 25.352 1.00 86.45 A N ATOM 2683 C LYS A 191 74.081 −43.581 19.467 1.00 70.30 A C ATOM 2684 O LYS A 191 74.929 −44.293 18.923 1.00 70.06 A O ATOM 2686 N ILE A 192 73.337 −42.700 18.803 1.00 68.27 A N ATOM 2687 CA ILE A 192 73.412 −42.559 17.344 1.00 67.41 A C ATOM 2689 CB ILE A 192 72.021 −42.259 16.721 1.00 66.84 A C ATOM 2691 CG1 ILE A 192 71.413 −40.959 17.266 1.00 66.08 A C ATOM 2694 CD1 ILE A 192 70.180 −40.498 16.516 1.00 61.79 A C ATOM 2698 CG2 ILE A 192 71.079 −43.397 17.011 1.00 66.67 A C ATOM 2702 C ILE A 192 74.418 −41.476 16.984 1.00 66.49 A C ATOM 2703 O ILE A 192 75.005 −40.860 17.864 1.00 65.60 A O ATOM 2705 N GLY A 193 74.623 −41.241 15.694 1.00 66.38 A N ATOM 2706 CA GLY A 193 75.553 −40.195 15.259 1.00 66.52 A C ATOM 2709 C GLY A 193 75.264 −38.810 15.831 1.00 65.05 A C ATOM 2710 O GLY A 193 74.192 −38.557 16.396 1.00 64.86 A O ATOM 2712 N LYS A 194 76.235 −37.910 15.701 1.00 62.68 A N ATOM 2713 CA LYS A 194 75.958 −36.492 15.879 1.00 61.11 A C ATOM 2715 CB LYS A 194 77.243 −35.657 15.953 1.00 62.09 A C ATOM 2718 CG LYS A 194 78.355 −36.254 16.839 1.00 69.49 A C ATOM 2721 CD LYS A 194 79.386 −35.198 17.291 1.00 73.25 A C ATOM 2724 CE LYS A 194 80.488 −35.828 18.136 1.00 73.20 A C ATOM 2727 NZ LYS A 194 81.352 −34.809 18.783 1.00 72.29 A N ATOM 2731 C LYS A 194 75.096 −36.058 14.680 1.00 58.07 A C ATOM 2732 O LYS A 194 74.119 −35.337 14.842 1.00 56.95 A O ATOM 2734 N GLU A 195 75.447 −36.528 13.484 1.00 54.22 A N ATOM 2735 CA GLU A 195 74.722 −36.140 12.287 1.00 53.49 A C ATOM 2737 CB GLU A 195 75.507 −36.489 11.005 1.00 53.97 A C ATOM 2740 CG GLU A 195 75.487 −37.950 10.549 1.00 60.23 A C ATOM 2743 CD GLU A 195 76.394 −38.208 9.329 1.00 66.28 A C ATOM 2744 OE1 GLU A 195 76.046 −39.079 8.500 1.00 68.96 A O ATOM 2745 OE2 GLU A 195 77.450 −37.544 9.194 1.00 62.48 A O ATOM 2746 C GLU A 195 73.296 −36.714 12.261 1.00 50.83 A C ATOM 2747 O GLU A 195 72.363 −36.050 11.773 1.00 48.97 A O ATOM 2749 N LEU A 196 73.125 −37.925 12.792 1.00 46.53 A N ATOM 2750 CA LEU A 196 71.808 −38.556 12.821 1.00 43.53 A C ATOM 2752 CB LEU A 196 71.892 −40.048 13.130 1.00 43.43 A C ATOM 2755 CG LEU A 196 71.893 −40.894 11.870 1.00 43.50 A C ATOM 2757 CD1 LEU A 196 72.472 −42.286 12.143 1.00 46.58 A C ATOM 2761 CD2 LEU A 196 70.472 −40.959 11.279 1.00 43.97 A C ATOM 2765 C LEU A 196 70.881 −37.857 13.799 1.00 40.68 A C ATOM 2766 O LEU A 196 69.731 −37.587 13.461 1.00 40.50 A O ATOM 2768 N ALA A 197 71.383 −37.531 14.983 1.00 36.99 A N ATOM 2769 CA ALA A 197 70.584 −36.804 15.961 1.00 35.57 A C ATOM 2771 CB ALA A 197 71.364 −36.595 17.246 1.00 33.51 A C ATOM 2775 C ALA A 197 70.119 −35.460 15.406 1.00 35.11 A C ATOM 2776 O ALA A 197 68.995 −35.042 15.677 1.00 35.72 A O ATOM 2778 N GLU A 198 70.986 −34.778 14.653 1.00 33.60 A N ATOM 2779 CA GLU A 198 70.605 −33.513 14.002 1.00 35.29 A C ATOM 2781 CB GLU A 198 71.836 −32.795 13.432 1.00 36.22 A C ATOM 2784 CG GLU A 198 72.762 −32.235 14.540 1.00 50.06 A C ATOM 2787 CD GLU A 198 74.148 −31.764 14.057 1.00 60.04 A C ATOM 2788 OE1 GLU A 198 74.806 −32.492 13.272 1.00 66.90 A O ATOM 2789 OE2 GLU A 198 74.585 −30.667 14.491 1.00 63.26 A O ATOM 2790 C GLU A 198 69.534 −33.754 12.916 1.00 31.70 A C ATOM 2791 O GLU A 198 68.608 −32.969 12.768 1.00 33.74 A O ATOM 2793 N GLN A 199 69.647 −34.857 12.201 1.00 28.08 A N ATOM 2794 CA GLN A 199 68.694 −35.215 11.158 1.00 29.52 A C ATOM 2796 CB GLN A 199 69.315 −36.342 10.323 1.00 30.33 A C ATOM 2799 CG GLN A 199 68.764 −36.594 8.954 1.00 42.18 A C ATOM 2802 CD GLN A 199 69.077 −35.489 7.927 1.00 53.91 A C ATOM 2803 OE1 GLN A 199 68.161 −34.927 7.316 1.00 54.02 A O ATOM 2804 NE2 GLN A 199 70.359 −35.211 7.705 1.00 47.12 A N ATOM 2807 C GLN A 199 67.326 −35.566 11.828 1.00 27.82 A C ATOM 2808 O GLN A 199 66.277 −35.071 11.419 1.00 24.92 A O ATOM 2810 N VAL A 200 67.361 −36.329 12.922 1.00 27.96 A N ATOM 2811 CA VAL A 200 66.162 −36.642 13.712 1.00 26.88 A C ATOM 2813 CB VAL A 200 66.485 −37.637 14.821 1.00 28.23 A C ATOM 2815 CG1 VAL A 200 66.795 −39.011 14.204 1.00 29.92 A C ATOM 2819 CG2 VAL A 200 65.342 −37.736 15.839 1.00 23.69 A C ATOM 2823 C VAL A 200 65.496 −35.422 14.336 1.00 27.44 A C ATOM 2824 O VAL A 200 64.277 −35.274 14.235 1.00 26.51 A O ATOM 2826 N ASN A 201 66.288 −34.536 14.946 1.00 27.44 A N ATOM 2827 CA ASN A 201 65.754 −33.319 15.554 1.00 29.08 A C ATOM 2829 CB ASN A 201 66.835 −32.603 16.398 1.00 30.46 A C ATOM 2832 CG ASN A 201 67.362 −33.468 17.575 1.00 34.58 A C ATOM 2833 OD1 ASN A 201 66.665 −34.330 18.124 1.00 43.42 A O ATOM 2834 ND2 ASN A 201 68.604 −33.231 17.947 1.00 39.12 A N ATOM 2837 C ASN A 201 65.140 −32.337 14.530 1.00 28.73 A C ATOM 2838 O ASN A 201 64.107 −31.710 14.783 1.00 27.87 A O ATOM 2840 N HIS A 202 65.784 −32.192 13.382 1.00 27.02 A N ATOM 2841 CA HIS A 202 65.237 −31.386 12.299 1.00 26.81 A C ATOM 2843 CB HIS A 202 66.303 −31.281 11.211 1.00 27.94 A C ATOM 2846 CG HIS A 202 65.862 −30.625 9.942 1.00 26.52 A C ATOM 2847 ND1 HIS A 202 65.804 −29.258 9.788 1.00 29.59 A N ATOM 2849 CE1 HIS A 202 65.435 −28.970 8.554 1.00 28.13 A C ATOM 2851 NE2 HIS A 202 65.288 −30.102 7.890 1.00 26.07 A N ATOM 2853 CD2 HIS A 202 65.564 −31.150 8.733 1.00 26.24 A C ATOM 2855 C HIS A 202 63.901 −32.018 11.785 1.00 25.69 A C ATOM 2856 O HIS A 202 62.890 −31.339 11.667 1.00 21.65 A O ATOM 2858 N ALA A 203 63.867 −33.315 11.553 1.00 25.23 A N ATOM 2859 CA ALA A 203 62.598 −33.931 11.112 1.00 25.49 A C ATOM 2861 CB ALA A 203 62.812 −35.337 10.748 1.00 24.59 A C ATOM 2865 C ALA A 203 61.489 −33.824 12.173 1.00 27.25 A C ATOM 2866 O ALA A 203 60.321 −33.627 11.837 1.00 29.18 A O ATOM 2868 N LEU A 204 61.839 −33.928 13.451 1.00 26.81 A N ATOM 2869 CA LEU A 204 60.807 −33.831 14.517 1.00 26.42 A C ATOM 2871 CB LEU A 204 61.317 −34.405 15.850 1.00 24.88 A C ATOM 2874 CG LEU A 204 61.517 −35.936 15.832 1.00 26.48 A C ATOM 2876 CD1 LEU A 204 62.119 −36.465 17.114 1.00 26.30 A C ATOM 2880 CD2 LEU A 204 60.203 −36.639 15.557 1.00 23.97 A C ATOM 2884 C LEU A 204 60.305 −32.392 14.672 1.00 27.71 A C ATOM 2885 O LEU A 204 59.148 −32.160 15.001 1.00 27.30 A O ATOM 2887 N GLU A 205 61.183 −31.430 14.415 1.00 27.31 A N ATOM 2888 CA GLU A 205 60.805 −30.037 14.394 1.00 27.78 A C ATOM 2890 CB GLU A 205 62.015 −29.143 14.068 1.00 27.71 A C ATOM 2893 CG GLU A 205 61.697 −27.658 14.056 1.00 29.29 A C ATOM 2896 CD GLU A 205 62.860 −26.816 13.541 1.00 37.90 A C ATOM 2897 OE1 GLU A 205 63.289 −27.047 12.395 1.00 32.00 A O ATOM 2898 OE2 GLU A 205 63.349 −25.930 14.288 1.00 44.77 A O ATOM 2899 C GLU A 205 59.729 −29.859 13.348 1.00 27.03 A C ATOM 2900 O GLU A 205 58.699 −29.270 13.627 1.00 27.56 A O ATOM 2902 N LEU A 206 59.982 −30.359 12.144 1.00 25.59 A N ATOM 2903 CA LEU A 206 59.004 −30.289 11.062 1.00 25.22 A C ATOM 2905 CB LEU A 206 58.886 −28.840 10.561 1.00 24.64 A C ATOM 2908 CG LEU A 206 57.694 −28.433 9.711 1.00 24.27 A C ATOM 2910 CD1 LEU A 206 56.411 −28.371 10.529 1.00 17.46 A C ATOM 2914 CD2 LEU A 206 57.955 −27.063 9.063 1.00 21.01 A C ATOM 2918 C LEU A 206 59.416 −31.196 9.917 1.00 24.56 A C ATOM 2919 O LEU A 206 60.540 −31.118 9.444 1.00 25.68 A O ATOM 2921 N PRO A 207 58.492 −32.045 9.437 1.00 24.29 A N ATOM 2922 CA PRO A 207 58.784 −32.963 8.354 1.00 23.07 A C ATOM 2924 CB PRO A 207 57.522 −33.795 8.289 1.00 25.30 A C ATOM 2927 CG PRO A 207 56.469 −32.830 8.679 1.00 25.11 A C ATOM 2930 CD PRO A 207 57.058 −32.039 9.765 1.00 23.79 A C ATOM 2933 C PRO A 207 59.003 −32.256 7.014 1.00 21.55 A C ATOM 2934 O PRO A 207 58.522 −31.166 6.819 1.00 22.11 A O ATOM 2935 N LEU A 208 59.694 −32.924 6.102 1.00 22.41 A N ATOM 2936 CA LEU A 208 60.022 −32.401 4.805 1.00 22.23 A C ATOM 2938 CB LEU A 208 60.690 −33.496 3.997 1.00 26.10 A C ATOM 2941 CG LEU A 208 62.061 −33.942 4.475 1.00 32.53 A C ATOM 2943 CD1 LEU A 208 62.395 −35.348 3.945 1.00 35.78 A C ATOM 2947 CD2 LEU A 208 63.091 −32.897 4.009 1.00 35.33 A C ATOM 2951 C LEU A 208 58.814 −31.930 4.019 1.00 23.30 A C ATOM 2952 O LEU A 208 58.865 −30.914 3.333 1.00 27.80 A O ATOM 2954 N HIS A 209 57.733 −32.688 4.081 1.00 21.48 A N ATOM 2955 CA HIS A 209 56.531 −32.356 3.333 1.00 20.94 A C ATOM 2957 CB HIS A 209 55.497 −33.453 3.521 1.00 20.23 A C ATOM 2960 CG HIS A 209 54.347 −33.380 2.571 1.00 21.97 A C ATOM 2961 ND1 HIS A 209 54.509 −33.408 1.200 1.00 19.00 A N ATOM 2963 CE1 HIS A 209 53.316 −33.366 0.621 1.00 17.86 A C ATOM 2965 NE2 HIS A 209 52.392 −33.319 1.568 1.00 20.62 A N ATOM 2967 CD2 HIS A 209 53.011 −33.333 2.797 1.00 17.40 A C ATOM 2969 C HIS A 209 55.890 −31.039 3.769 1.00 20.60 A C ATOM 2970 O HIS A 209 55.095 −30.479 3.030 1.00 22.10 A O ATOM 2972 N ARG A 210 56.182 −30.578 4.970 1.00 19.06 A N ATOM 2973 CA ARG A 210 55.590 −29.330 5.442 1.00 21.68 A C ATOM 2975 CB ARG A 210 54.984 −29.513 6.825 1.00 21.62 A C ATOM 2978 CG ARG A 210 53.868 −30.527 6.845 1.00 21.69 A C ATOM 2981 CD ARG A 210 53.157 −30.548 8.198 1.00 21.87 A C ATOM 2984 NE ARG A 210 52.032 −31.469 8.145 1.00 28.50 A N ATOM 2986 CZ ARG A 210 51.306 −31.867 9.185 1.00 27.73 A C ATOM 2987 NH1 ARG A 210 51.565 −31.422 10.396 1.00 25.20 A N ATOM 2990 NH2 ARG A 210 50.306 −32.732 9.001 1.00 22.65 A N ATOM 2993 C ARG A 210 56.554 −28.162 5.510 1.00 23.56 A C ATOM 2994 O ARG A 210 56.098 −27.052 5.712 1.00 25.20 A O ATOM 2996 N ARG A 211 57.861 −28.390 5.317 1.00 22.15 A N ATOM 2997 CA ARG A 211 58.824 −27.328 5.454 1.00 22.08 A C ATOM 2999 CB ARG A 211 60.164 −27.898 5.911 1.00 21.53 A C ATOM 3002 CG ARG A 211 61.184 −26.803 6.252 1.00 25.30 A C ATOM 3005 CD ARG A 211 62.498 −27.377 6.683 1.00 23.90 A C ATOM 3008 NE ARG A 211 62.394 −28.298 7.815 1.00 20.68 A N ATOM 3010 CZ ARG A 211 62.577 −27.968 9.097 1.00 29.21 A C ATOM 3011 NH1 ARG A 211 62.842 −26.723 9.458 1.00 31.64 A N ATOM 3014 NH2 ARG A 211 62.482 −28.895 10.040 1.00 33.26 A N ATOM 3017 C ARG A 211 58.995 −26.636 4.124 1.00 22.87 A C ATOM 3018 O ARG A 211 58.943 −27.308 3.080 1.00 23.69 A O ATOM 3020 N THR A 212 59.225 −25.313 4.131 1.00 21.93 A N ATOM 3021 CA THR A 212 59.457 −24.587 2.846 1.00 22.40 A C ATOM 3023 CB THR A 212 59.553 −23.073 3.006 1.00 21.65 A C ATOM 3025 OG1 THR A 212 60.391 −22.782 4.111 1.00 28.79 A O ATOM 3027 CG2 THR A 212 58.204 −22.457 3.215 1.00 21.41 A C ATOM 3031 C THR A 212 60.748 −25.035 2.161 1.00 24.44 A C ATOM 3032 O THR A 212 61.667 −25.593 2.790 1.00 22.73 A O ATOM 3034 N GLN A 213 60.831 −24.769 0.862 1.00 24.88 A N ATOM 3035 CA GLN A 213 61.890 −25.361 0.042 1.00 23.30 A C ATOM 3037 CB GLN A 213 61.510 −25.230 −1.431 1.00 22.38 A C ATOM 3040 CG GLN A 213 62.232 −26.167 −2.392 1.00 26.87 A C ATOM 3043 CD GLN A 213 63.551 −25.606 −2.913 1.00 30.03 A C ATOM 3044 OE1 GLN A 213 64.199 −24.764 −2.277 1.00 31.33 A O ATOM 3045 NE2 GLN A 213 63.969 −26.095 −4.062 1.00 27.33 A N ATOM 3048 C GLN A 213 63.238 −24.674 0.385 1.00 23.77 A C ATOM 3049 O GLN A 213 64.269 −25.339 0.641 1.00 23.11 A O ATOM 3051 N ARG A 214 63.242 −23.348 0.444 1.00 22.75 A N ATOM 3052 CA ARG A 214 64.496 −22.646 0.771 1.00 22.94 A C ATOM 3054 CB ARG A 214 64.351 −21.150 0.591 1.00 21.67 A C ATOM 3057 CG ARG A 214 64.105 −20.728 −0.863 1.00 25.36 A C ATOM 3060 CD ARG A 214 65.370 −20.851 −1.745 1.00 25.37 A C ATOM 3063 NE ARG A 214 65.517 −22.198 −2.265 1.00 19.85 A N ATOM 3065 CZ ARG A 214 66.500 −22.609 −3.067 1.00 22.24 A C ATOM 3066 NH1 ARG A 214 67.440 −21.780 −3.482 1.00 23.25 A N ATOM 3069 NH2 ARG A 214 66.530 −23.870 −3.478 1.00 21.78 A N ATOM 3072 C ARG A 214 65.045 −22.987 2.163 1.00 22.57 A C ATOM 3073 O ARG A 214 66.276 −23.153 2.325 1.00 22.67 A O ATOM 3075 N LEU A 215 64.168 −23.142 3.156 1.00 21.88 A N ATOM 3076 CA LEU A 215 64.640 −23.425 4.534 1.00 22.10 A C ATOM 3078 CB LEU A 215 63.530 −23.342 5.574 1.00 23.69 A C ATOM 3081 CG LEU A 215 63.166 −22.064 6.320 1.00 34.74 A C ATOM 3083 CD1 LEU A 215 64.377 −21.478 7.038 1.00 30.99 A C ATOM 3087 CD2 LEU A 215 62.022 −22.394 7.334 1.00 34.69 A C ATOM 3091 C LEU A 215 65.225 −24.807 4.601 1.00 21.97 A C ATOM 3092 O LEU A 215 66.251 −25.033 5.243 1.00 23.04 A O ATOM 3094 N GLU A 216 64.563 −25.759 3.964 1.00 22.38 A N ATOM 3095 CA GLU A 216 65.143 −27.091 3.849 1.00 23.79 A C ATOM 3097 CB GLU A 216 64.203 −28.054 3.092 1.00 24.11 A C ATOM 3100 CG GLU A 216 64.735 −29.469 3.009 1.00 23.98 A C ATOM 3103 CD GLU A 216 65.092 −30.054 4.372 1.00 30.09 A C ATOM 3104 OE1 GLU A 216 64.489 −29.635 5.368 1.00 38.31 A O ATOM 3105 OE2 GLU A 216 65.963 −30.950 4.462 1.00 31.71 A O ATOM 3106 C GLU A 216 66.495 −27.043 3.151 1.00 22.00 A C ATOM 3107 O GLU A 216 67.417 −27.725 3.566 1.00 25.42 A O ATOM 3109 N ALA A 217 66.609 −26.265 2.075 1.00 21.69 A N ATOM 3110 CA ALA A 217 67.860 −26.207 1.307 1.00 21.04 A C ATOM 3112 CB ALA A 217 67.713 −25.322 0.057 1.00 16.62 A C ATOM 3116 C ALA A 217 68.997 −25.695 2.170 1.00 22.50 A C ATOM 3117 O ALA A 217 70.086 −26.294 2.207 1.00 24.32 A O ATOM 3119 N VAL A 218 68.754 −24.598 2.880 1.00 22.51 A N ATOM 3120 CA VAL A 218 69.841 −23.970 3.638 1.00 23.74 A C ATOM 3122 CB VAL A 218 69.501 −22.546 4.127 1.00 24.58 A C ATOM 3124 CG1 VAL A 218 68.630 −22.593 5.350 1.00 23.58 A C ATOM 3128 CG2 VAL A 218 70.816 −21.738 4.397 1.00 28.37 A C ATOM 3132 C VAL A 218 70.244 −24.871 4.785 1.00 23.83 A C ATOM 3133 O VAL A 218 71.408 −24.959 5.120 1.00 28.06 A O ATOM 3135 N TRP A 219 69.292 −25.582 5.366 1.00 25.17 A N ATOM 3136 CA TRP A 219 69.614 −26.553 6.384 1.00 24.87 A C ATOM 3138 CB TRP A 219 68.353 −27.038 7.105 1.00 25.79 A C ATOM 3141 CG TRP A 219 68.684 −27.877 8.273 1.00 25.24 A C ATOM 3142 CD1 TRP A 219 68.904 −27.444 9.559 1.00 26.80 A C ATOM 3144 NE1 TRP A 219 69.218 −28.508 10.361 1.00 24.26 A N ATOM 3146 CE2 TRP A 219 69.240 −29.648 9.604 1.00 28.74 A C ATOM 3147 CD2 TRP A 219 68.921 −29.281 8.274 1.00 20.92 A C ATOM 3148 CE3 TRP A 219 68.869 −30.273 7.291 1.00 28.67 A C ATOM 3150 CZ3 TRP A 219 69.133 −31.587 7.659 1.00 31.01 A C ATOM 3152 CH2 TRP A 219 69.464 −31.920 8.991 1.00 31.59 A C ATOM 3154 CZ2 TRP A 219 69.524 −30.968 9.974 1.00 31.18 A C ATOM 3156 C TRP A 219 70.368 −27.756 5.817 1.00 23.79 A C ATOM 3157 O TRP A 219 71.341 −28.186 6.403 1.00 26.06 A O ATOM 3159 N SER A 220 69.912 −28.314 4.700 1.00 23.59 A N ATOM 3160 CA SER A 220 70.515 −29.556 4.168 1.00 23.50 A C ATOM 3162 CB SER A 220 69.604 −30.197 3.104 1.00 23.55 A C ATOM 3165 OG SER A 220 68.632 −31.034 3.711 1.00 29.70 A O ATOM 3167 C SER A 220 71.909 −29.365 3.572 1.00 23.39 A C ATOM 3168 O SER A 220 72.739 −30.270 3.630 1.00 25.12 A O ATOM 3170 N ILE A 221 72.141 −28.206 2.976 1.00 23.77 A N ATOM 3171 CA ILE A 221 73.448 −27.844 2.429 1.00 27.11 A C ATOM 3173 CB ILE A 221 73.397 −26.472 1.704 1.00 26.36 A C ATOM 3175 CG1 ILE A 221 72.680 −26.608 0.360 1.00 22.83 A C ATOM 3178 CD1 ILE A 221 72.358 −25.299 −0.336 1.00 15.93 A C ATOM 3182 CG2 ILE A 221 74.804 −25.940 1.473 1.00 28.45 A C ATOM 3186 C ILE A 221 74.509 −27.769 3.525 1.00 28.33 A C ATOM 3187 O ILE A 221 75.621 −28.265 3.366 1.00 28.37 A O ATOM 3189 N GLU A 222 74.165 −27.148 4.640 1.00 29.36 A N ATOM 3190 CA GLU A 222 75.089 −27.078 5.770 1.00 29.36 A C ATOM 3192 CB GLU A 222 74.540 −26.124 6.842 1.00 29.54 A C ATOM 3195 CG GLU A 222 75.301 −26.042 8.170 1.00 37.23 A C ATOM 3198 CD GLU A 222 76.756 −25.564 8.041 1.00 40.53 A C ATOM 3199 OE1 GLU A 222 77.153 −25.010 6.984 1.00 44.11 A O ATOM 3200 OE2 GLU A 222 77.499 −25.737 9.030 1.00 46.46 A O ATOM 3201 C GLU A 222 75.311 −28.503 6.286 1.00 29.13 A C ATOM 3202 O GLU A 222 76.438 −28.891 6.532 1.00 28.56 A O ATOM 3204 N ALA A 223 74.246 −29.305 6.379 1.00 28.23 A N ATOM 3205 CA ALA A 223 74.377 −30.670 6.882 1.00 27.59 A C ATOM 3207 CB ALA A 223 73.003 −31.344 7.026 1.00 29.69 A C ATOM 3211 C ALA A 223 75.255 −31.497 5.959 1.00 28.61 A C ATOM 3212 O ALA A 223 76.131 −32.225 6.420 1.00 28.90 A O ATOM 3214 N TYR A 224 74.995 −31.386 4.657 1.00 27.73 A N ATOM 3215 CA TYR A 224 75.677 −32.186 3.652 1.00 28.06 A C ATOM 3217 CB TYR A 224 75.020 −31.964 2.284 1.00 26.68 A C ATOM 3220 CG TYR A 224 75.272 −33.036 1.247 1.00 23.01 A C ATOM 3221 CD1 TYR A 224 74.715 −34.296 1.372 1.00 24.54 A C ATOM 3223 CE1 TYR A 224 74.929 −35.278 0.410 1.00 28.25 A C ATOM 3225 CZ TYR A 224 75.687 −34.995 −0.710 1.00 26.14 A C ATOM 3226 OH TYR A 224 75.902 −35.965 −1.669 1.00 30.14 A O ATOM 3228 CE2 TYR A 224 76.244 −33.755 −0.859 1.00 24.49 A C ATOM 3230 CD2 TYR A 224 76.030 −32.772 0.112 1.00 25.46 A C ATOM 3232 C TYR A 224 77.166 −31.809 3.607 1.00 28.75 A C ATOM 3233 O TYR A 224 78.029 −32.671 3.448 1.00 27.95 A O ATOM 3235 N ARG A 225 77.452 −30.525 3.769 1.00 29.70 A N ATOM 3236 CA ARG A 225 78.833 −30.042 3.733 1.00 34.37 A C ATOM 3238 CB ARG A 225 78.874 −28.525 3.945 1.00 34.39 A C ATOM 3241 CG ARG A 225 80.182 −27.914 3.518 1.00 42.08 A C ATOM 3244 CD ARG A 225 80.440 −26.599 4.201 1.00 44.17 A C ATOM 3247 NE ARG A 225 79.492 −25.587 3.768 1.00 33.41 A N ATOM 3249 CZ ARG A 225 79.757 −24.598 2.921 1.00 31.84 A C ATOM 3250 NH1 ARG A 225 80.969 −24.440 2.360 1.00 26.16 A N ATOM 3253 NH2 ARG A 225 78.789 −23.732 2.647 1.00 28.39 A N ATOM 3256 C ARG A 225 79.731 −30.720 4.782 1.00 34.95 A C ATOM 3257 O ARG A 225 80.924 −30.847 4.571 1.00 33.72 A O ATOM 3259 N LYS A 226 79.148 −31.153 5.897 1.00 38.87 A N ATOM 3260 CA LYS A 226 79.895 −31.805 6.980 1.00 41.98 A C ATOM 3262 CB LYS A 226 79.195 −31.585 8.323 1.00 41.81 A C ATOM 3265 CG LYS A 226 79.118 −30.139 8.760 1.00 43.92 A C ATOM 3268 CD LYS A 226 78.200 −30.008 9.967 1.00 48.86 A C ATOM 3271 CE LYS A 226 77.814 −28.571 10.214 1.00 50.51 A C ATOM 3274 NZ LYS A 226 76.638 −28.436 11.125 1.00 50.92 A N ATOM 3278 C LYS A 226 80.099 −33.305 6.780 1.00 43.06 A C ATOM 3279 O LYS A 226 80.952 −33.885 7.435 1.00 43.06 A O ATOM 3281 N LYS A 227 79.322 −33.938 5.905 1.00 44.99 A N ATOM 3282 CA LYS A 227 79.499 −35.372 5.641 1.00 46.76 A C ATOM 3284 CB LYS A 227 78.334 −35.933 4.840 1.00 46.98 A C ATOM 3287 CG LYS A 227 76.994 −35.858 5.523 1.00 51.16 A C ATOM 3290 CD LYS A 227 76.018 −36.864 4.900 1.00 58.14 A C ATOM 3293 CE LYS A 227 74.634 −36.793 5.566 1.00 65.96 A C ATOM 3296 NZ LYS A 227 74.529 −37.575 6.846 1.00 67.08 A N ATOM 3300 C LYS A 227 80.786 −35.607 4.854 1.00 48.34 A C ATOM 3301 O LYS A 227 80.992 −34.995 3.799 1.00 48.62 A O ATOM 3303 N GLU A 228 81.638 −36.503 5.359 1.00 49.33 A N ATOM 3304 CA GLU A 228 82.956 −36.761 4.757 1.00 49.51 A C ATOM 3306 CB GLU A 228 83.814 −37.641 5.689 1.00 50.88 A C ATOM 3309 CG GLU A 228 85.196 −38.038 5.113 1.00 58.59 A C ATOM 3312 CD GLU A 228 86.120 −38.742 6.127 1.00 63.27 A C ATOM 3313 OE1 GLU A 228 86.715 −38.048 6.986 1.00 63.25 A O ATOM 3314 OE2 GLU A 228 86.269 −39.985 6.040 1.00 60.49 A O ATOM 3315 C GLU A 228 82.839 −37.401 3.370 1.00 47.39 A C ATOM 3316 O GLU A 228 83.681 −37.153 2.503 1.00 48.29 A O ATOM 3318 N ASP A 229 81.792 −38.204 3.173 1.00 43.95 A N ATOM 3319 CA ASP A 229 81.528 −38.887 1.903 1.00 42.40 A C ATOM 3321 CB ASP A 229 81.004 −40.301 2.198 1.00 44.51 A C ATOM 3324 CG ASP A 229 79.635 −40.288 2.889 1.00 48.08 A C ATOM 3325 OD1 ASP A 229 79.412 −39.414 3.764 1.00 52.32 A O ATOM 3326 OD2 ASP A 229 78.791 −41.154 2.563 1.00 55.55 A O ATOM 3327 C ASP A 229 80.505 −38.161 1.001 1.00 39.47 A C ATOM 3328 O ASP A 229 79.905 −38.774 0.111 1.00 38.26 A O ATOM 3330 N ALA A 230 80.287 −36.871 1.232 1.00 35.85 A N ATOM 3331 CA ALA A 230 79.406 −36.089 0.360 1.00 34.54 A C ATOM 3333 CB ALA A 230 79.252 −34.654 0.911 1.00 34.43 A C ATOM 3337 C ALA A 230 79.943 −36.039 −1.075 1.00 31.71 A C ATOM 3338 O ALA A 230 81.139 −35.893 −1.293 1.00 31.71 A O ATOM 3340 N ASN A 231 79.052 −36.149 −2.048 1.00 30.30 A N ATOM 3341 CA ASN A 231 79.405 −35.899 −3.445 1.00 29.41 A C ATOM 3343 CB ASN A 231 78.209 −36.246 −4.341 1.00 28.84 A C ATOM 3346 CG ASN A 231 78.477 −36.010 −5.831 1.00 33.88 A C ATOM 3347 OD1 ASN A 231 79.040 −34.979 −6.245 1.00 29.21 A O ATOM 3348 ND2 ASN A 231 78.034 −36.955 −6.647 1.00 39.93 A N ATOM 3351 C ASN A 231 79.790 −34.424 −3.610 1.00 28.30 A C ATOM 3352 O ASN A 231 78.954 −33.553 −3.407 1.00 29.80 A O ATOM 3354 N GLN A 232 81.032 −34.144 −3.987 1.00 26.07 A N ATOM 3355 CA GLN A 232 81.501 −32.758 −4.080 1.00 26.86 A C ATOM 3357 CB GLN A 232 83.033 −32.713 −4.132 1.00 28.05 A C ATOM 3360 CG GLN A 232 83.748 −33.343 −2.907 1.00 32.80 A C ATOM 3363 CD GLN A 232 83.312 −32.742 −1.576 1.00 33.27 A C ATOM 3364 OE1 GLN A 232 83.561 −31.573 −1.287 1.00 32.93 A O ATOM 3365 NE2 GLN A 232 82.657 −33.550 −0.762 1.00 34.64 A N ATOM 3368 C GLN A 232 80.914 −31.962 −5.265 1.00 26.08 A C ATOM 3369 O GLN A 232 80.757 −30.731 −5.179 1.00 26.37 A O ATOM 3371 N VAL A 233 80.598 −32.647 −6.363 1.00 23.92 A N ATOM 3372 CA VAL A 233 79.939 −32.005 −7.513 1.00 23.21 A C ATOM 3374 CB VAL A 233 79.852 −32.957 −8.737 1.00 24.28 A C ATOM 3376 CG1 VAL A 233 78.831 −32.450 −9.732 1.00 19.74 A C ATOM 3380 CG2 VAL A 233 81.256 −33.115 −9.399 1.00 23.81 A C ATOM 3384 C VAL A 233 78.535 −31.501 −7.127 1.00 23.21 A C ATOM 3385 O VAL A 233 78.180 −30.351 −7.391 1.00 21.93 A O ATOM 3387 N LEU A 234 77.774 −32.344 −6.435 1.00 22.20 A N ATOM 3388 CA LEU A 234 76.438 −31.982 −5.981 1.00 22.67 A C ATOM 3390 CB LEU A 234 75.746 −33.221 −5.425 1.00 24.22 A C ATOM 3393 CG LEU A 234 74.276 −33.151 −4.995 1.00 25.50 A C ATOM 3395 CD1 LEU A 234 73.370 −32.553 −6.102 1.00 18.15 A C ATOM 3399 CD2 LEU A 234 73.833 −34.547 −4.622 1.00 18.42 A C ATOM 3403 C LEU A 234 76.469 −30.846 −4.941 1.00 23.82 A C ATOM 3404 O LEU A 234 75.701 −29.896 −5.041 1.00 24.91 A O ATOM 3406 N LEU A 235 77.374 −30.930 −3.966 1.00 23.57 A N ATOM 3407 CA LEU A 235 77.510 −29.892 −2.946 1.00 22.98 A C ATOM 3409 CB LEU A 235 78.597 −30.259 −1.944 1.00 24.41 A C ATOM 3412 CG LEU A 235 78.878 −29.265 −0.815 1.00 26.92 A C ATOM 3414 CD1 LEU A 235 77.604 −29.078 0.019 1.00 15.89 A C ATOM 3418 CD2 LEU A 235 80.061 −29.754 0.038 1.00 18.04 A C ATOM 3422 C LEU A 235 77.842 −28.566 −3.580 1.00 20.58 A C ATOM 3423 O LEU A 235 77.236 −27.545 −3.277 1.00 19.83 A O ATOM 3425 N GLU A 236 78.801 −28.572 −4.482 1.00 22.61 A N ATOM 3426 CA GLU A 236 79.170 −27.327 −5.122 1.00 22.75 A C ATOM 3428 CB GLU A 236 80.383 −27.502 −6.026 1.00 22.70 A C ATOM 3431 CG GLU A 236 80.871 −26.189 −6.606 1.00 23.04 A C ATOM 3434 CD GLU A 236 82.258 −26.245 −7.215 1.00 27.07 A C ATOM 3435 OE1 GLU A 236 82.771 −27.340 −7.541 1.00 33.98 A O ATOM 3436 OE2 GLU A 236 82.838 −25.154 −7.363 1.00 30.70 A O ATOM 3437 C GLU A 236 77.973 −26.757 −5.875 1.00 21.06 A C ATOM 3438 O GLU A 236 77.621 −25.602 −5.693 1.00 23.31 A O ATOM 3440 N LEU A 237 77.318 −27.567 −6.691 1.00 22.06 A N ATOM 3441 CA LEU A 237 76.183 −27.054 −7.480 1.00 19.57 A C ATOM 3443 CB LEU A 237 75.566 −28.155 −8.336 1.00 15.98 A C ATOM 3446 CG LEU A 237 74.366 −27.737 −9.187 1.00 15.57 A C ATOM 3448 CD1 LEU A 237 74.786 −26.710 −10.243 1.00 14.06 A C ATOM 3452 CD2 LEU A 237 73.740 −28.975 −9.837 1.00 15.04 A C ATOM 3456 C LEU A 237 75.133 −26.460 −6.562 1.00 19.31 A C ATOM 3457 O LEU A 237 74.608 −25.393 −6.820 1.00 20.86 A O ATOM 3459 N ALA A 238 74.846 −27.161 −5.474 1.00 19.04 A N ATOM 3460 CA ALA A 238 73.834 −26.739 −4.531 1.00 18.52 A C ATOM 3462 CB ALA A 238 73.675 −27.811 −3.413 1.00 18.25 A C ATOM 3466 C ALA A 238 74.193 −25.392 −3.927 1.00 19.60 A C ATOM 3467 O ALA A 238 73.350 −24.489 −3.794 1.00 21.50 A O ATOM 3469 N ILE A 239 75.448 −25.233 −3.539 1.00 19.28 A N ATOM 3470 CA ILE A 239 75.849 −23.943 −2.994 1.00 19.80 A C ATOM 3472 CB ILE A 239 77.274 −23.988 −2.476 1.00 20.00 A C ATOM 3474 CG1 ILE A 239 77.319 −24.875 −1.218 1.00 17.31 A C ATOM 3477 CD1 ILE A 239 78.704 −25.050 −0.668 1.00 21.36 A C ATOM 3481 CG2 ILE A 239 77.786 −22.592 −2.202 1.00 17.51 A C ATOM 3485 C ILE A 239 75.665 −22.871 −4.062 1.00 20.41 A C ATOM 3486 O ILE A 239 75.042 −21.848 −3.806 1.00 19.36 A O ATOM 3488 N LEU A 240 76.198 −23.118 −5.258 1.00 21.30 A N ATOM 3489 CA LEU A 240 76.149 −22.135 −6.356 1.00 21.36 A C ATOM 3491 CB LEU A 240 76.776 −22.696 −7.645 1.00 22.81 A C ATOM 3494 CG LEU A 240 78.227 −22.426 −7.967 1.00 30.14 A C ATOM 3496 CD1 LEU A 240 78.568 −23.128 −9.255 1.00 32.64 A C ATOM 3500 CD2 LEU A 240 79.131 −22.906 −6.840 1.00 37.35 A C ATOM 3504 C LEU A 240 74.719 −21.794 −6.687 1.00 20.26 A C ATOM 3505 O LEU A 240 74.394 −20.648 −6.875 1.00 21.20 A O ATOM 3507 N ASP A 241 73.864 −22.806 −6.784 1.00 19.89 A N ATOM 3508 CA ASP A 241 72.482 −22.569 −7.156 1.00 20.98 A C ATOM 3510 CB ASP A 241 71.727 −23.866 −7.456 1.00 20.86 A C ATOM 3513 CG ASP A 241 70.487 −23.614 −8.317 1.00 26.59 A C ATOM 3514 OD1 ASP A 241 69.370 −23.431 −7.778 1.00 23.99 A O ATOM 3515 OD2 ASP A 241 70.638 −23.525 −9.538 1.00 24.62 A O ATOM 3516 C ASP A 241 71.741 −21.775 −6.091 1.00 21.28 A C ATOM 3517 O ASP A 241 70.980 −20.872 −6.411 1.00 22.40 A O ATOM 3519 N TYR A 242 71.967 −22.089 −4.828 1.00 20.15 A N ATOM 3520 CA TYR A 242 71.259 −21.393 −3.771 1.00 20.85 A C ATOM 3522 CB TYR A 242 71.568 −22.050 −2.438 1.00 22.45 A C ATOM 3525 CG TYR A 242 70.857 −21.437 −1.265 1.00 23.33 A C ATOM 3526 CD1 TYR A 242 69.691 −21.998 −0.761 1.00 18.55 A C ATOM 3528 CE1 TYR A 242 69.041 −21.418 0.330 1.00 24.47 A C ATOM 3530 CZ TYR A 242 69.569 −20.276 0.908 1.00 18.54 A C ATOM 3531 OH TYR A 242 68.956 −19.675 1.972 1.00 25.94 A O ATOM 3533 CE2 TYR A 242 70.713 −19.709 0.406 1.00 21.27 A C ATOM 3535 CD2 TYR A 242 71.346 −20.283 −0.666 1.00 19.29 A C ATOM 3537 C TYR A 242 71.620 −19.907 −3.718 1.00 22.79 A C ATOM 3538 O TYR A 242 70.727 −19.047 −3.526 1.00 22.49 A O ATOM 3540 N ASN A 243 72.912 −19.603 −3.864 1.00 20.76 A N ATOM 3541 CA ASN A 243 73.375 −18.205 −3.845 1.00 22.06 A C ATOM 3543 CB ASN A 243 74.906 −18.124 −3.672 1.00 20.78 A C ATOM 3546 CG ASN A 243 75.349 −18.533 −2.275 1.00 25.87 A C ATOM 3547 OD1 ASN A 243 74.529 −18.590 −1.347 1.00 27.54 A O ATOM 3548 ND2 ASN A 243 76.639 −18.815 −2.110 1.00 19.91 A N ATOM 3551 C ASN A 243 72.933 −17.409 −5.066 1.00 21.72 A C ATOM 3552 O ASN A 243 72.662 −16.203 −4.983 1.00 22.95 A O ATOM 3554 N MET A 244 72.846 −18.070 −6.205 1.00 21.84 A N ATOM 3555 CA MET A 244 72.301 −17.412 −7.384 1.00 23.63 A C ATOM 3557 CB MET A 244 72.478 −18.316 −8.582 1.00 23.14 A C ATOM 3560 CG MET A 244 71.729 −17.885 −9.801 1.00 25.17 A C ATOM 3563 SD MET A 244 71.520 −19.311 −10.849 1.00 37.78 A S ATOM 3564 CE MET A 244 70.066 −20.130 −10.156 1.00 36.34 A C ATOM 3568 C MET A 244 70.810 −17.060 −7.194 1.00 24.55 A C ATOM 3569 O MET A 244 70.367 −15.958 −7.524 1.00 27.20 A O ATOM 3571 N ILE A 245 70.029 −17.988 −6.665 1.00 23.34 A N ATOM 3572 CA ILE A 245 68.612 −17.708 −6.487 1.00 23.03 A C ATOM 3574 CB ILE A 245 67.828 −18.961 −6.067 1.00 23.79 A C ATOM 3576 CG1 ILE A 245 67.753 −19.935 −7.251 1.00 24.90 A C ATOM 3579 CD1 ILE A 245 67.053 −21.262 −6.934 1.00 20.17 A C ATOM 3583 CG2 ILE A 245 66.428 −18.579 −5.537 1.00 18.88 A C ATOM 3587 C ILE A 245 68.452 −16.565 −5.475 1.00 22.27 A C ATOM 3588 O ILE A 245 67.673 −15.646 −5.689 1.00 23.18 A O ATOM 3590 N GLN A 246 69.222 −16.618 −4.400 1.00 21.78 A N ATOM 3591 CA GLN A 246 69.201 −15.585 −3.385 1.00 22.32 A C ATOM 3593 CB GLN A 246 70.192 −15.913 −2.267 1.00 22.29 A C ATOM 3596 CG GLN A 246 70.105 −14.977 −1.079 1.00 22.47 A C ATOM 3599 CD GLN A 246 71.193 −15.238 −0.086 1.00 23.64 A C ATOM 3600 OE1 GLN A 246 72.333 −14.876 −0.330 1.00 30.86 A O ATOM 3601 NE2 GLN A 246 70.855 −15.897 1.046 1.00 27.00 A N ATOM 3604 C GLN A 246 69.519 −14.220 −3.969 1.00 25.79 A C ATOM 3605 O GLN A 246 68.906 −13.227 −3.574 1.00 28.66 A O ATOM 3607 N SER A 247 70.448 −14.156 −4.918 1.00 24.24 A N ATOM 3608 CA SER A 247 70.741 −12.881 −5.566 1.00 25.76 A C ATOM 3610 CB SER A 247 71.984 −12.957 −6.460 1.00 25.65 A C ATOM 3613 OG SER A 247 71.670 −13.655 −7.661 1.00 32.02 A O ATOM 3615 C SER A 247 69.557 −12.390 −6.377 1.00 24.68 A C ATOM 3616 O SER A 247 69.434 −11.184 −6.615 1.00 26.69 A O ATOM 3618 N VAL A 248 68.700 −13.295 −6.833 1.00 23.54 A N ATOM 3619 CA VAL A 248 67.456 −12.855 −7.466 1.00 23.71 A C ATOM 3621 CB VAL A 248 66.766 −13.966 −8.265 1.00 26.06 A C ATOM 3623 CG1 VAL A 248 65.435 −13.455 −8.867 1.00 19.39 A C ATOM 3627 CG2 VAL A 248 67.716 −14.472 −9.386 1.00 23.18 A C ATOM 3631 C VAL A 248 66.521 −12.281 −6.398 1.00 25.20 A C ATOM 3632 O VAL A 248 65.871 −11.268 −6.617 1.00 28.02 A O ATOM 3634 N TYR A 249 66.482 −12.898 −5.231 1.00 23.81 A N ATOM 3635 CA TYR A 249 65.652 −12.372 −4.165 1.00 27.09 A C ATOM 3637 CB TYR A 249 65.642 −13.297 −2.919 1.00 27.78 A C ATOM 3640 CG TYR A 249 65.127 −14.716 −3.122 1.00 22.87 A C ATOM 3641 CD1 TYR A 249 64.358 −15.066 −4.225 1.00 20.29 A C ATOM 3643 CE1 TYR A 249 63.892 −16.351 −4.383 1.00 20.19 A C ATOM 3645 CZ TYR A 249 64.185 −17.292 −3.431 1.00 24.01 A C ATOM 3646 OH TYR A 249 63.731 −18.576 −3.586 1.00 21.28 A O ATOM 3648 CE2 TYR A 249 64.938 −16.969 −2.329 1.00 17.32 A C ATOM 3650 CD2 TYR A 249 65.402 −15.698 −2.185 1.00 22.81 A C ATOM 3652 C TYR A 249 66.152 −10.995 −3.752 1.00 28.26 A C ATOM 3653 O TYR A 249 65.361 −10.086 −3.502 1.00 28.96 A O ATOM 3655 N GLN A 250 67.470 −10.835 −3.655 1.00 30.13 A N ATOM 3656 CA GLN A 250 68.017 −9.558 −3.209 1.00 29.19 A C ATOM 3658 CB GLN A 250 69.523 −9.646 −2.980 1.00 29.25 A C ATOM 3661 CG GLN A 250 69.842 −10.420 −1.714 1.00 27.79 A C ATOM 3664 CD GLN A 250 71.234 −11.016 −1.662 1.00 32.54 A C ATOM 3665 OE1 GLN A 250 72.048 −10.868 −2.584 1.00 30.29 A O ATOM 3666 NE2 GLN A 250 71.510 −11.717 −0.573 1.00 28.97 A N ATOM 3669 C GLN A 250 67.616 −8.450 −4.174 1.00 29.47 A C ATOM 3670 O GLN A 250 67.253 −7.356 −3.727 1.00 30.74 A O ATOM 3672 N ARG A 251 67.600 −8.748 −5.471 1.00 29.60 A N ATOM 3673 CA ARG A 251 67.112 −7.789 −6.465 1.00 30.89 A C ATOM 3675 CB ARG A 251 67.463 −8.185 −7.905 1.00 32.50 A C ATOM 3678 CG ARG A 251 67.113 −7.073 −8.936 1.00 40.34 A C ATOM 3681 CD ARG A 251 67.748 −7.272 −10.319 1.00 50.67 A C ATOM 3684 NE ARG A 251 67.564 −8.647 −10.781 1.00 60.70 A N ATOM 3686 CZ ARG A 251 68.526 −9.565 −10.909 1.00 68.22 A C ATOM 3687 NH1 ARG A 251 69.808 −9.281 −10.650 1.00 66.48 A N ATOM 3690 NH2 ARG A 251 68.200 −10.793 −11.318 1.00 67.68 A N ATOM 3693 C ARG A 251 65.621 −7.568 −6.373 1.00 30.00 A C ATOM 3694 O ARG A 251 65.156 −6.438 −6.483 1.00 31.03 A O ATOM 3696 N ASP A 252 64.855 −8.637 −6.197 1.00 29.66 A N ATOM 3697 CA ASP A 252 63.422 −8.487 −6.004 1.00 27.76 A C ATOM 3699 CB ASP A 252 62.766 −9.838 −5.688 1.00 28.05 A C ATOM 3702 CG ASP A 252 62.734 −10.802 −6.881 1.00 31.72 A C ATOM 3703 OD1 ASP A 252 62.980 −10.396 −8.039 1.00 32.65 A O ATOM 3704 OD2 ASP A 252 62.453 −11.998 −6.635 1.00 31.73 A O ATOM 3705 C ASP A 252 63.149 −7.507 −4.849 1.00 27.28 A C ATOM 3706 O ASP A 252 62.343 −6.590 −4.965 1.00 28.15 A O ATOM 3708 N LEU A 253 63.831 −7.709 −3.738 1.00 28.14 A N ATOM 3709 CA LEU A 253 63.621 −6.912 −2.539 1.00 29.87 A C ATOM 3711 CB LEU A 253 64.347 −7.566 −1.372 1.00 29.41 A C ATOM 3714 CG LEU A 253 64.118 −6.971 −0.001 1.00 34.75 A C ATOM 3716 CD1 LEU A 253 62.630 −6.934 0.321 1.00 26.24 A C ATOM 3720 CD2 LEU A 253 64.893 −7.766 1.038 1.00 36.83 A C ATOM 3724 C LEU A 253 64.071 −5.451 −2.681 1.00 31.45 A C ATOM 3725 O LEU A 253 63.406 −4.547 −2.168 1.00 32.50 A O ATOM 3727 N ARG A 254 65.180 −5.203 −3.364 1.00 33.17 A N ATOM 3728 CA ARG A 254 65.632 −3.810 −3.557 1.00 34.97 A C ATOM 3730 CB ARG A 254 66.973 −3.726 −4.297 1.00 35.48 A C ATOM 3733 CG ARG A 254 68.190 −3.919 −3.399 1.00 40.57 A C ATOM 3736 CD ARG A 254 69.493 −3.551 −4.113 1.00 42.70 A C ATOM 3739 NE ARG A 254 69.666 −4.290 −5.366 1.00 42.33 A N ATOM 3741 CZ ARG A 254 70.190 −5.516 −5.483 1.00 43.80 A C ATOM 3742 NH1 ARG A 254 70.619 −6.197 −4.422 1.00 40.69 A N ATOM 3745 NH2 ARG A 254 70.293 −6.067 −6.689 1.00 45.83 A N ATOM 3748 C ARG A 254 64.563 −3.054 −4.316 1.00 34.14 A C ATOM 3749 O ARG A 254 64.154 −1.977 −3.915 1.00 35.76 A O ATOM 3751 N GLU A 255 64.096 −3.667 −5.390 1.00 34.42 A N ATOM 3752 CA GLU A 255 63.024 −3.139 −6.221 1.00 36.63 A C ATOM 3754 CB GLU A 255 62.724 −4.179 −7.296 1.00 38.74 A C ATOM 3757 CG GLU A 255 61.825 −3.773 −8.455 1.00 50.85 A C ATOM 3760 CD GLU A 255 61.681 −4.909 −9.497 1.00 60.07 A C ATOM 3761 OE1 GLU A 255 62.720 −5.463 −9.957 1.00 60.17 A O ATOM 3762 OE2 GLU A 255 60.523 −5.246 −9.844 1.00 63.55 A O ATOM 3763 C GLU A 255 61.756 −2.831 −5.420 1.00 36.27 A C ATOM 3764 O GLU A 255 61.129 −1.794 −5.593 1.00 39.35 A O ATOM 3766 N THR A 256 61.383 −3.739 −4.539 1.00 33.73 A N ATOM 3767 CA THR A 256 60.151 −3.622 −3.790 1.00 31.80 A C ATOM 3769 CB THR A 256 59.703 −5.018 −3.323 1.00 30.64 A C ATOM 3771 OG1 THR A 256 59.309 −5.757 −4.469 1.00 33.76 A O ATOM 3773 CG2 THR A 256 58.537 −4.966 −2.325 1.00 32.44 A C ATOM 3777 C THR A 256 60.360 −2.667 −2.618 1.00 30.31 A C ATOM 3778 O THR A 256 59.460 −1.916 −2.260 1.00 29.39 A O ATOM 3780 N SER A 257 61.544 −2.705 −2.022 1.00 30.11 A N ATOM 3781 CA SER A 257 61.920 −1.693 −1.036 1.00 33.18 A C ATOM 3783 CB SER A 257 63.327 −1.943 −0.475 1.00 32.22 A C ATOM 3786 OG SER A 257 63.336 −3.128 0.297 1.00 33.34 A O ATOM 3788 C SER A 257 61.834 −0.281 −1.621 1.00 33.22 A C ATOM 3789 O SER A 257 61.449 0.638 −0.907 1.00 33.37 A O ATOM 3791 N ARG A 258 62.173 −0.111 −2.901 1.00 32.43 A N ATOM 3792 CA ARG A 258 62.019 1.204 −3.565 1.00 35.63 A C ATOM 3794 CB ARG A 258 62.525 1.207 −5.024 1.00 38.19 A C ATOM 3797 CG ARG A 258 63.974 1.629 −5.235 1.00 43.51 A C ATOM 3800 CD ARG A 258 64.204 2.128 −6.670 1.00 49.21 A C ATOM 3803 NE ARG A 258 63.874 1.127 −7.692 1.00 50.92 A N ATOM 3805 CZ ARG A 258 64.697 0.173 −8.133 1.00 57.27 A C ATOM 3806 NH1 ARG A 258 64.275 −0.679 −9.060 1.00 57.78 A N ATOM 3809 NH2 ARG A 258 65.935 0.050 −7.653 1.00 60.74 A N ATOM 3812 C ARG A 258 60.571 1.623 −3.602 1.00 33.91 A C ATOM 3813 O ARG A 258 60.254 2.753 −3.318 1.00 33.23 A O ATOM 3815 N TRP A 259 59.697 0.714 −4.015 1.00 33.11 A N ATOM 3816 CA TRP A 259 58.266 1.003 −4.026 1.00 32.00 A C ATOM 3818 CB TRP A 259 57.487 −0.183 −4.587 1.00 31.64 A C ATOM 3821 CG TRP A 259 56.053 −0.155 −4.267 1.00 27.92 A C ATOM 3822 CD1 TRP A 259 55.084 0.569 −4.900 1.00 32.00 A C ATOM 3824 NE1 TRP A 259 53.861 0.357 −4.299 1.00 30.37 A N ATOM 3826 CE2 TRP A 259 54.033 −0.523 −3.264 1.00 26.02 A C ATOM 3827 CD2 TRP A 259 55.400 −0.861 −3.211 1.00 28.92 A C ATOM 3828 CE3 TRP A 259 55.839 −1.732 −2.212 1.00 24.22 A C ATOM 3830 CZ3 TRP A 259 54.932 −2.229 −1.337 1.00 28.49 A C ATOM 3832 CH2 TRP A 259 53.584 −1.882 −1.425 1.00 32.67 A C ATOM 3834 CZ2 TRP A 259 53.125 −1.025 −2.382 1.00 22.99 A C ATOM 3836 C TRP A 259 57.753 1.358 −2.623 1.00 31.98 A C ATOM 3837 O TRP A 259 56.957 2.274 −2.465 1.00 34.30 A O ATOM 3839 N TRP A 260 58.224 0.639 −1.611 1.00 30.69 A N ATOM 3840 CA TRP A 260 57.676 0.755 −0.270 1.00 29.45 A C ATOM 3842 CB TRP A 260 58.190 −0.399 0.578 1.00 29.19 A C ATOM 3845 CG TRP A 260 57.621 −0.512 1.985 1.00 32.70 A C ATOM 3846 CD1 TRP A 260 58.333 −0.569 3.137 1.00 31.86 A C ATOM 3848 NE1 TRP A 260 57.489 −0.698 4.209 1.00 33.52 A N ATOM 3850 CE2 TRP A 260 56.202 −0.741 3.762 1.00 27.99 A C ATOM 3851 CD2 TRP A 260 56.240 −0.627 2.364 1.00 25.33 A C ATOM 3852 CE3 TRP A 260 55.038 −0.632 1.658 1.00 28.45 A C ATOM 3854 CZ3 TRP A 260 53.863 −0.755 2.356 1.00 24.24 A C ATOM 3856 CH2 TRP A 260 53.859 −0.875 3.741 1.00 29.24 A C ATOM 3858 CZ2 TRP A 260 55.017 −0.858 4.466 1.00 31.81 A C ATOM 3860 C TRP A 260 58.052 2.102 0.332 1.00 29.67 A C ATOM 3861 O TRP A 260 57.218 2.763 0.934 1.00 26.76 A O ATOM 3863 N ARG A 261 59.288 2.528 0.111 1.00 32.87 A N ATOM 3864 CA AARG A 261 59.778 3.810 0.630 0.50 35.92 A C ATOM 3865 CA BARG A 261 59.768 3.809 0.649 0.50 35.98 A C ATOM 3868 CB AARG A 261 61.299 3.917 0.447 0.50 36.14 A C ATOM 3869 CB BARG A 261 61.293 3.938 0.514 0.50 36.20 A C ATOM 3874 CG AARG A 261 62.081 3.255 1.576 0.50 40.00 A C ATOM 3875 CG BARG A 261 61.962 4.656 1.691 0.50 40.66 A C ATOM 3880 CD AARG A 261 63.347 2.553 1.086 0.50 45.53 A C ATOM 3881 CD BARG A 261 61.787 3.877 3.002 0.50 44.00 A C ATOM 3886 NE AARG A 261 63.970 3.229 −0.049 0.50 45.59 A N ATOM 3887 NE BARG A 261 62.789 4.234 4.005 0.50 45.46 A N ATOM 3890 CZ AARG A 261 64.845 2.643 −0.856 0.50 42.15 A C ATOM 3891 CZ BARG A 261 62.660 5.236 4.869 0.50 50.02 A C ATOM 3892 NH1 AARG A 261 65.188 1.382 −0.637 0.50 33.28 A N ATOM 3893 NH1 BARG A 261 61.567 5.987 4.861 0.50 49.40 A N ATOM 3898 NH2 AARG A 261 65.370 3.311 −1.874 0.50 42.47 A N ATOM 3899 NH2 BARG A 261 63.625 5.484 5.745 0.50 49.02 A N ATOM 3904 C ARG A 261 59.061 4.997 −0.024 1.00 37.61 A C ATOM 3905 O ARG A 261 58.729 5.981 0.642 1.00 38.28 A O ATOM 3907 N ARG A 262 58.808 4.897 −1.327 1.00 38.01 A N ATOM 3908 CA ARG A 262 58.026 5.922 −2.019 1.00 39.29 A C ATOM 3910 CB ARG A 262 57.878 5.607 −3.516 1.00 42.22 A C ATOM 3913 CG ARG A 262 59.136 5.898 −4.350 1.00 52.27 A C ATOM 3916 CD ARG A 262 58.787 6.242 −5.811 1.00 62.63 A C ATOM 3919 NE ARG A 262 57.884 5.261 −6.428 1.00 67.61 A N ATOM 3921 CZ ARG A 262 58.273 4.146 −7.054 1.00 71.86 A C ATOM 3922 NH1 ARG A 262 59.567 3.837 −7.171 1.00 69.63 A N ATOM 3925 NH2 ARG A 262 57.354 3.328 −7.566 1.00 71.10 A N ATOM 3928 C ARG A 262 56.646 6.038 −1.398 1.00 35.13 A C ATOM 3929 O ARG A 262 56.192 7.127 −1.072 1.00 39.41 A O ATOM 3931 N VAL A 263 55.978 4.913 −1.229 1.00 31.29 A N ATOM 3932 CA VAL A 263 54.684 4.899 −0.577 1.00 28.48 A C ATOM 3934 CB VAL A 263 54.116 3.501 −0.518 1.00 26.56 A C ATOM 3936 CG1 VAL A 263 53.801 3.029 −1.925 1.00 30.17 A C ATOM 3940 CG2 VAL A 263 52.879 3.480 0.354 1.00 27.85 A C ATOM 3944 C VAL A 263 54.745 5.479 0.844 1.00 28.20 A C ATOM 3945 O VAL A 263 53.801 6.150 1.259 1.00 26.93 A O ATOM 3947 N GLY A 264 55.847 5.199 1.559 1.00 28.31 A N ATOM 3948 CA GLY A 264 56.160 5.750 2.871 1.00 27.54 A C ATOM 3951 C GLY A 264 55.063 5.691 3.909 1.00 29.80 A C ATOM 3952 O GLY A 264 54.978 6.560 4.760 1.00 32.57 A O ATOM 3954 N LEU A 265 54.219 4.673 3.842 1.00 32.96 A N ATOM 3955 CA LEU A 265 53.026 4.593 4.679 1.00 36.19 A C ATOM 3957 CB LEU A 265 52.050 3.553 4.111 1.00 34.50 A C ATOM 3960 CG LEU A 265 50.568 3.516 4.505 1.00 36.39 A C ATOM 3962 CD1 LEU A 265 49.833 4.834 4.299 1.00 27.01 A C ATOM 3966 CD2 LEU A 265 49.858 2.406 3.721 1.00 31.32 A C ATOM 3970 C LEU A 265 53.376 4.316 6.151 1.00 40.47 A C ATOM 3971 O LEU A 265 52.828 4.964 7.046 1.00 41.90 A O ATOM 3973 N ALA A 266 54.306 3.402 6.413 1.00 45.05 A N ATOM 3974 CA ALA A 266 54.692 3.097 7.803 1.00 48.60 A C ATOM 3976 CB ALA A 266 55.536 1.834 7.871 1.00 49.61 A C ATOM 3980 C ALA A 266 55.414 4.263 8.486 1.00 50.25 A C ATOM 3981 O ALA A 266 55.437 4.354 9.709 1.00 53.50 A O ATOM 3983 N THR A 267 55.989 5.161 7.693 1.00 51.71 A N ATOM 3984 CA THR A 267 56.599 6.383 8.220 1.00 50.87 A C ATOM 3986 CB THR A 267 57.494 7.042 7.158 1.00 50.67 A C ATOM 3988 OG1 THR A 267 58.268 6.030 6.501 1.00 54.33 A O ATOM 3990 CG2 THR A 267 58.420 8.057 7.783 1.00 53.96 A C ATOM 3994 C THR A 267 55.537 7.383 8.678 1.00 49.72 A C ATOM 3995 O THR A 267 55.657 7.966 9.753 1.00 51.35 A O ATOM 3997 N LYS A 268 54.494 7.567 7.870 1.00 47.73 A N ATOM 3998 CA LYS A 268 53.515 8.655 8.074 1.00 45.94 A C ATOM 4000 CB LYS A 268 52.935 9.113 6.720 1.00 46.30 A C ATOM 4003 CG LYS A 268 53.986 9.658 5.725 1.00 47.05 A C ATOM 4006 CD LYS A 268 54.376 11.104 6.011 1.00 49.29 A C ATOM 4009 CE LYS A 268 55.573 11.543 5.161 1.00 52.85 A C ATOM 4012 NZ LYS A 268 55.780 13.020 5.207 1.00 54.81 A N ATOM 4016 C LYS A 268 52.378 8.275 9.024 1.00 44.32 A C ATOM 4017 O LYS A 268 51.749 9.148 9.610 1.00 44.98 A O ATOM 4019 N LEU A 269 52.095 6.980 9.138 1.00 43.49 A N ATOM 4020 CA LEU A 269 51.151 6.457 10.122 1.00 43.04 A C ATOM 4022 CB LEU A 269 50.429 5.222 9.561 1.00 42.92 A C ATOM 4025 CG LEU A 269 49.100 5.381 8.814 1.00 42.16 A C ATOM 4027 CD1 LEU A 269 49.147 6.491 7.813 1.00 38.88 A C ATOM 4031 CD2 LEU A 269 48.721 4.062 8.144 1.00 40.39 A C ATOM 4035 C LEU A 269 51.943 6.068 11.380 1.00 43.46 A C ATOM 4036 O LEU A 269 52.741 5.132 11.344 1.00 45.75 A O ATOM 4038 N HIS A 270 51.718 6.762 12.489 1.00 42.57 A N ATOM 4039 CA HIS A 270 52.559 6.585 13.689 1.00 42.20 A C ATOM 4041 CB HIS A 270 52.334 7.730 14.706 1.00 43.68 A C ATOM 4044 CG HIS A 270 52.315 9.101 14.088 1.00 55.54 A C ATOM 4045 ND1 HIS A 270 53.195 9.489 13.097 1.00 59.69 A N ATOM 4047 CE1 HIS A 270 52.936 10.737 12.746 1.00 62.20 A C ATOM 4049 NE2 HIS A 270 51.925 11.177 13.475 1.00 61.94 A N ATOM 4051 CD2 HIS A 270 51.515 10.173 14.321 1.00 61.38 A C ATOM 4053 C HIS A 270 52.340 5.224 14.372 1.00 37.82 A C ATOM 4054 O HIS A 270 53.221 4.720 15.063 1.00 35.89 A O ATOM 4056 N PHE A 271 51.160 4.649 14.178 1.00 34.74 A N ATOM 4057 CA PHE A 271 50.818 3.349 14.756 1.00 35.98 A C ATOM 4059 CB PHE A 271 49.297 3.246 14.975 1.00 36.24 A C ATOM 4062 CG PHE A 271 48.513 3.176 13.700 1.00 32.72 A C ATOM 4063 CD1 PHE A 271 48.245 1.962 13.107 1.00 36.61 A C ATOM 4065 CE1 PHE A 271 47.542 1.895 11.905 1.00 41.78 A C ATOM 4067 CZ PHE A 271 47.106 3.050 11.293 1.00 39.23 A C ATOM 4069 CE2 PHE A 271 47.370 4.267 11.868 1.00 40.49 A C ATOM 4071 CD2 PHE A 271 48.081 4.330 13.072 1.00 36.58 A C ATOM 4073 C PHE A 271 51.277 2.144 13.928 1.00 36.24 A C ATOM 4074 O PHE A 271 51.232 1.028 14.425 1.00 36.55 A O ATOM 4076 N ALA A 272 51.705 2.352 12.681 1.00 36.36 A N ATOM 4077 CA ALA A 272 51.905 1.217 11.753 1.00 38.44 A C ATOM 4079 CB ALA A 272 51.767 1.683 10.299 1.00 37.11 A C ATOM 4083 C ALA A 272 53.235 0.493 11.939 1.00 37.87 A C ATOM 4084 O ALA A 272 54.260 1.128 12.126 1.00 38.46 A O ATOM 4086 N ARG A 273 53.199 −0.838 11.895 1.00 39.95 A N ATOM 4087 CA ARG A 273 54.415 −1.651 11.843 1.00 42.71 A C ATOM 4089 CB ARG A 273 54.161 −3.077 12.354 1.00 44.71 A C ATOM 4092 CG ARG A 273 53.612 −3.232 13.785 1.00 52.26 A C ATOM 4095 CD ARG A 273 53.137 −4.699 14.060 1.00 58.75 A C ATOM 4098 NE ARG A 273 51.872 −5.018 13.384 1.00 59.61 A N ATOM 4100 CZ ARG A 273 51.440 −6.241 13.062 1.00 65.74 A C ATOM 4101 NH1 ARG A 273 52.168 −7.320 13.327 1.00 72.19 A N ATOM 4104 NH2 ARG A 273 50.268 −6.390 12.441 1.00 62.91 A N ATOM 4107 C ARG A 273 54.886 −1.731 10.387 1.00 41.28 A C ATOM 4108 O ARG A 273 54.067 −1.896 9.486 1.00 42.18 A O ATOM 4110 N ASP A 274 56.195 −1.605 10.171 1.00 40.00 A N ATOM 4111 CA ASP A 274 56.819 −1.798 8.854 1.00 38.76 A C ATOM 4113 CB ASP A 274 57.983 −0.808 8.684 1.00 38.55 A C ATOM 4116 CG ASP A 274 58.733 −0.993 7.370 1.00 42.03 A C ATOM 4117 OD1 ASP A 274 58.666 −2.086 6.781 1.00 39.25 A O ATOM 4118 OD2 ASP A 274 59.404 −0.044 6.918 1.00 46.81 A O ATOM 4119 C ASP A 274 57.306 −3.260 8.725 1.00 37.31 A C ATOM 4120 O ASP A 274 58.281 −3.644 9.349 1.00 36.99 A O ATOM 4122 N ARG A 275 56.612 −4.069 7.925 1.00 37.37 A N ATOM 4123 CA ARG A 275 56.889 −5.498 7.826 1.00 37.69 A C ATOM 4125 CB ARG A 275 55.702 −6.299 8.391 1.00 39.25 A C ATOM 4128 CG ARG A 275 55.490 −6.180 9.913 1.00 47.84 A C ATOM 4131 CD ARG A 275 56.044 −7.381 10.697 1.00 59.27 A C ATOM 4134 NE ARG A 275 55.924 −7.187 12.150 1.00 68.25 A N ATOM 4136 CZ ARG A 275 56.679 −6.355 12.886 1.00 74.47 A C ATOM 4137 NH1 ARG A 275 57.641 −5.618 12.324 1.00 74.61 A N ATOM 4140 NH2 ARG A 275 56.473 −6.252 14.204 1.00 72.98 A N ATOM 4143 C ARG A 275 57.168 −5.943 6.388 1.00 36.06 A C ATOM 4144 O ARG A 275 56.729 −7.017 5.973 1.00 35.65 A O ATOM 4146 N LEU A 276 57.898 −5.137 5.623 1.00 35.38 A N ATOM 4147 CA LEU A 276 58.209 −5.505 4.231 1.00 34.05 A C ATOM 4149 CB LEU A 276 58.824 −4.340 3.438 1.00 35.05 A C ATOM 4152 CG LEU A 276 59.320 −4.741 2.049 1.00 34.24 A C ATOM 4154 CD1 LEU A 276 58.157 −5.203 1.208 1.00 37.51 A C ATOM 4158 CD2 LEU A 276 60.030 −3.629 1.374 1.00 37.66 A C ATOM 4162 C LEU A 276 59.147 −6.698 4.170 1.00 31.37 A C ATOM 4163 O LEU A 276 58.890 −7.636 3.443 1.00 30.37 A O ATOM 4165 N ILE A 277 60.221 −6.664 4.950 1.00 30.01 A N ATOM 4166 CA ILE A 277 61.242 −7.701 4.870 1.00 29.44 A C ATOM 4168 CB ILE A 277 62.459 −7.360 5.755 1.00 30.70 A C ATOM 4170 CG1 ILE A 277 63.124 −6.061 5.253 1.00 35.07 A C ATOM 4173 CD1 ILE A 277 64.038 −5.345 6.291 1.00 36.73 A C ATOM 4177 CG2 ILE A 277 63.463 −8.487 5.705 1.00 27.89 A C ATOM 4181 C ILE A 277 60.654 −9.045 5.267 1.00 28.92 A C ATOM 4182 O ILE A 277 60.847 −10.054 4.583 1.00 28.83 A O ATOM 4184 N GLU A 278 59.905 −9.048 6.359 1.00 27.84 A N ATOM 4185 CA GLU A 278 59.220 −10.244 6.818 1.00 29.71 A C ATOM 4187 CB GLU A 278 58.538 −9.966 8.161 1.00 30.64 A C ATOM 4190 CG GLU A 278 59.515 −9.600 9.291 1.00 41.88 A C ATOM 4193 CD GLU A 278 59.736 −8.097 9.493 1.00 50.18 A C ATOM 4194 OE1 GLU A 278 59.920 −7.333 8.508 1.00 48.05 A O ATOM 4195 OE2 GLU A 278 59.742 −7.686 10.673 1.00 59.82 A O ATOM 4196 C GLU A 278 58.197 −10.733 5.761 1.00 28.62 A C ATOM 4197 O GLU A 278 58.066 −11.929 5.519 1.00 28.77 A O ATOM 4199 N SER A 279 57.509 −9.791 5.114 1.00 25.67 A N ATOM 4200 CA SER A 279 56.510 −10.111 4.115 1.00 25.01 A C ATOM 4202 CB SER A 279 55.694 −8.869 3.762 1.00 26.35 A C ATOM 4205 OG SER A 279 54.839 −8.541 4.839 1.00 32.90 A O ATOM 4207 C SER A 279 57.152 −10.682 2.875 1.00 24.05 A C ATOM 4208 O SER A 279 56.560 −11.514 2.223 1.00 23.50 A O ATOM 4210 N PHE A 280 58.365 −10.237 2.551 1.00 21.71 A N ATOM 4211 CA PHE A 280 59.091 −10.801 1.419 1.00 23.37 A C ATOM 4213 CB PHE A 280 60.266 −9.902 1.017 1.00 25.01 A C ATOM 4216 CG PHE A 280 60.841 −10.261 −0.298 1.00 22.72 A C ATOM 4217 CD1 PHE A 280 60.259 −9.812 −1.466 1.00 26.45 A C ATOM 4219 CE1 PHE A 280 60.747 −10.180 −2.677 1.00 25.95 A C ATOM 4221 CZ PHE A 280 61.836 −11.022 −2.737 1.00 25.35 A C ATOM 4223 CE2 PHE A 280 62.415 −11.486 −1.584 1.00 24.77 A C ATOM 4225 CD2 PHE A 280 61.917 −11.108 −0.370 1.00 26.82 A C ATOM 4227 C PHE A 280 59.599 −12.226 1.709 1.00 23.03 A C ATOM 4228 O PHE A 280 59.491 −13.103 0.863 1.00 25.85 A O ATOM 4230 N TYR A 281 60.156 −12.429 2.896 1.00 23.11 A N ATOM 4231 CA TYR A 281 60.546 −13.751 3.392 1.00 24.07 A C ATOM 4233 CB TYR A 281 61.140 −13.640 4.806 1.00 24.19 A C ATOM 4236 CG TYR A 281 61.313 −14.958 5.545 1.00 26.46 A C ATOM 4237 CD1 TYR A 281 62.469 −15.728 5.401 1.00 28.95 A C ATOM 4239 CE1 TYR A 281 62.607 −16.960 6.070 1.00 32.82 A C ATOM 4241 CZ TYR A 281 61.584 −17.403 6.899 1.00 23.73 A C ATOM 4242 OH TYR A 281 61.699 −18.572 7.602 1.00 37.06 A O ATOM 4244 CE2 TYR A 281 60.463 −16.627 7.091 1.00 27.38 A C ATOM 4246 CD2 TYR A 281 60.336 −15.409 6.424 1.00 28.38 A C ATOM 4248 C TYR A 281 59.327 −14.681 3.339 1.00 23.90 A C ATOM 4249 O TYR A 281 59.407 −15.778 2.841 1.00 22.03 A O ATOM 4251 N TRP A 282 58.178 −14.190 3.769 1.00 24.19 A N ATOM 4252 CA TRP A 282 56.946 −14.940 3.645 1.00 23.89 A C ATOM 4254 CB TRP A 282 55.772 −14.098 4.127 1.00 24.11 A C ATOM 4257 CG TRP A 282 54.466 −14.809 4.037 1.00 24.19 A C ATOM 4258 CD1 TRP A 282 53.597 −14.786 2.998 1.00 22.17 A C ATOM 4260 NE1 TRP A 282 52.491 −15.562 3.279 1.00 24.03 A N ATOM 4262 CE2 TRP A 282 52.657 −16.120 4.518 1.00 27.44 A C ATOM 4263 CD2 TRP A 282 53.888 −15.656 5.029 1.00 23.48 A C ATOM 4264 CE3 TRP A 282 54.291 −16.075 6.296 1.00 29.21 A C ATOM 4266 CZ3 TRP A 282 53.470 −16.930 7.001 1.00 30.47 A C ATOM 4268 CH2 TRP A 282 52.255 −17.363 6.468 1.00 29.72 A C ATOM 4270 CZ2 TRP A 282 51.830 −16.962 5.233 1.00 25.51 A C ATOM 4272 C TRP A 282 56.717 −15.400 2.195 1.00 24.21 A C ATOM 4273 O TRP A 282 56.504 −16.587 1.947 1.00 22.03 A O ATOM 4275 N ALA A 283 56.806 −14.455 1.259 1.00 22.23 A N ATOM 4276 CA ALA A 283 56.573 −14.706 −0.165 1.00 20.96 A C ATOM 4278 CB ALA A 283 56.663 −13.402 −0.961 1.00 18.60 A C ATOM 4282 C ALA A 283 57.522 −15.728 −0.781 1.00 21.39 A C ATOM 4283 O ALA A 283 57.118 −16.474 −1.679 1.00 20.52 A O ATOM 4285 N VAL A 284 58.769 −15.754 −0.318 1.00 22.30 A N ATOM 4286 CA VAL A 284 59.758 −16.758 −0.764 1.00 23.58 A C ATOM 4288 CB VAL A 284 61.144 −16.478 −0.111 1.00 24.57 A C ATOM 4290 CG1 VAL A 284 61.727 −15.180 −0.672 1.00 19.22 A C ATOM 4294 CG2 VAL A 284 62.095 −17.641 −0.320 1.00 19.35 A C ATOM 4298 C VAL A 284 59.302 −18.202 −0.456 1.00 24.32 A C ATOM 4299 O VAL A 284 59.566 −19.151 −1.208 1.00 23.82 A O ATOM 4301 N GLY A 285 58.599 −18.369 0.649 1.00 24.47 A N ATOM 4302 CA GLY A 285 57.973 −19.648 0.958 1.00 21.25 A C ATOM 4305 C GLY A 285 56.907 −20.048 −0.031 1.00 20.54 A C ATOM 4306 O GLY A 285 56.745 −21.226 −0.300 1.00 22.10 A O ATOM 4308 N VAL A 286 56.162 −19.078 −0.547 1.00 22.33 A N ATOM 4309 CA VAL A 286 55.029 −19.347 −1.441 1.00 20.31 A C ATOM 4311 CB VAL A 286 54.045 −18.169 −1.463 1.00 23.35 A C ATOM 4313 CG1 VAL A 286 52.961 −18.408 −2.468 1.00 22.65 A C ATOM 4317 CG2 VAL A 286 53.388 −17.973 −0.051 1.00 22.60 A C ATOM 4321 C VAL A 286 55.529 −19.659 −2.834 1.00 22.01 A C ATOM 4322 O VAL A 286 55.056 −20.605 −3.472 1.00 22.74 A O ATOM 4324 N ALA A 287 56.540 −18.915 −3.279 1.00 21.32 A N ATOM 4325 CA ALA A 287 57.034 −19.003 −4.629 1.00 20.30 A C ATOM 4327 CB ALA A 287 56.297 −17.991 −5.503 1.00 21.67 A C ATOM 4331 C ALA A 287 58.540 −18.779 −4.678 1.00 23.56 A C ATOM 4332 O ALA A 287 59.038 −17.632 −4.868 1.00 25.80 A O ATOM 4334 N PHE A 288 59.286 −19.860 −4.502 1.00 21.24 A N ATOM 4335 CA PHE A 288 60.720 −19.748 −4.348 1.00 22.02 A C ATOM 4337 CB PHE A 288 61.254 −20.872 −3.493 1.00 22.68 A C ATOM 4340 CG PHE A 288 61.372 −22.180 −4.225 1.00 26.97 A C ATOM 4341 CD1 PHE A 288 62.541 −22.512 −4.885 1.00 31.37 A C ATOM 4343 CE1 PHE A 288 62.649 −23.713 −5.570 1.00 35.11 A C ATOM 4345 CZ PHE A 288 61.587 −24.584 −5.596 1.00 29.46 A C ATOM 4347 CE2 PHE A 288 60.415 −24.273 −4.937 1.00 33.40 A C ATOM 4349 CD2 PHE A 288 60.310 −23.067 −4.255 1.00 33.76 A C ATOM 4351 C PHE A 288 61.451 −19.743 −5.697 1.00 26.03 A C ATOM 4352 O PHE A 288 62.568 −19.226 −5.784 1.00 25.19 A O ATOM 4354 N GLU A 289 60.836 −20.322 −6.734 1.00 27.65 A N ATOM 4355 CA GLU A 289 61.515 −20.489 −8.023 1.00 30.57 A C ATOM 4357 CB GLU A 289 60.643 −21.265 −9.023 1.00 32.76 A C ATOM 4360 CG GLU A 289 60.270 −22.716 −8.620 1.00 35.64 A C ATOM 4363 CD GLU A 289 58.926 −22.861 −7.872 1.00 42.73 A C ATOM 4364 OE1 GLU A 289 58.488 −21.920 −7.160 1.00 37.11 A O ATOM 4365 OE2 GLU A 289 58.306 −23.949 −8.008 1.00 42.82 A O ATOM 4366 C GLU A 289 61.916 −19.123 −8.599 1.00 30.30 A C ATOM 4367 O GLU A 289 61.153 −18.141 −8.491 1.00 29.03 A O ATOM 4369 N PRO A 290 63.115 −19.049 −9.204 1.00 28.09 A N ATOM 4370 CA PRO A 290 63.664 −17.754 −9.554 1.00 29.01 A C ATOM 4372 CB PRO A 290 65.013 −18.089 −10.205 1.00 29.11 A C ATOM 4375 CG PRO A 290 64.972 −19.515 −10.485 1.00 29.92 A C ATOM 4378 CD PRO A 290 64.059 −20.129 −9.491 1.00 29.29 A C ATOM 4381 C PRO A 290 62.789 −16.958 −10.500 1.00 28.51 A C ATOM 4382 O PRO A 290 62.732 −15.737 −10.385 1.00 28.65 A O ATOM 4383 N GLN A 291 62.099 −17.650 −11.397 1.00 27.75 A N ATOM 4384 CA GLN A 291 61.250 −16.998 −12.382 1.00 28.53 A C ATOM 4386 CB GLN A 291 60.845 −17.961 −13.519 1.00 27.02 A C ATOM 4389 CG GLN A 291 59.893 −19.074 −13.155 1.00 31.90 A C ATOM 4392 CD GLN A 291 60.583 −20.284 −12.532 1.00 38.40 A C ATOM 4393 OE1 GLN A 291 61.709 −20.183 −12.037 1.00 39.73 A O ATOM 4394 NE2 GLN A 291 59.911 −21.449 −12.576 1.00 32.16 A N ATOM 4397 C GLN A 291 59.993 −16.369 −11.795 1.00 29.44 A C ATOM 4398 O GLN A 291 59.343 −15.592 −12.496 1.00 31.07 A O ATOM 4400 N TYR A 292 59.633 −16.690 −10.547 1.00 28.42 A N ATOM 4401 CA TYR A 292 58.398 −16.147 −9.951 1.00 27.91 A C ATOM 4403 CB TYR A 292 57.733 −17.182 −9.046 1.00 30.21 A C ATOM 4406 CG TYR A 292 57.131 −18.402 −9.740 1.00 31.70 A C ATOM 4407 CD1 TYR A 292 56.502 −18.299 −10.975 1.00 31.99 A C ATOM 4409 CE1 TYR A 292 55.951 −19.407 −11.591 1.00 39.31 A C ATOM 4411 CZ TYR A 292 55.999 −20.641 −10.970 1.00 38.20 A C ATOM 4412 OH TYR A 292 55.441 −21.716 −11.596 1.00 45.03 A O ATOM 4414 CE2 TYR A 292 56.601 −20.781 −9.735 1.00 42.05 A C ATOM 4416 CD2 TYR A 292 57.166 −19.663 −9.126 1.00 39.69 A C ATOM 4418 C TYR A 292 58.594 −14.816 −9.182 1.00 28.53 A C ATOM 4419 O TYR A 292 57.989 −14.590 −8.118 1.00 25.90 A O ATOM 4421 N SER A 293 59.398 −13.916 −9.747 1.00 28.30 A N ATOM 4422 CA SER A 293 59.641 −12.601 −9.135 1.00 28.09 A C ATOM 4424 CB SER A 293 60.602 −11.763 −10.009 1.00 29.47 A C ATOM 4427 OG SER A 293 61.965 −11.924 −9.592 1.00 29.79 A O ATOM 4429 C SER A 293 58.352 −11.808 −8.874 1.00 28.45 A C ATOM 4430 O SER A 293 58.189 −11.199 −7.805 1.00 28.09 A O ATOM 4432 N ASP A 294 57.449 −11.808 −9.855 1.00 26.88 A N ATOM 4433 CA ASP A 294 56.223 −11.048 −9.784 1.00 25.77 A C ATOM 4435 CB ASP A 294 55.461 −11.124 −11.117 1.00 28.17 A C ATOM 4438 CG ASP A 294 56.157 −10.395 −12.248 1.00 34.74 A C ATOM 4439 OD1 ASP A 294 56.956 −9.462 −12.000 1.00 36.83 A O ATOM 4440 OD2 ASP A 294 55.888 −10.765 −13.412 1.00 45.26 A O ATOM 4441 C ASP A 294 55.313 −11.591 −8.684 1.00 28.84 A C ATOM 4442 O ASP A 294 54.585 −10.823 −8.009 1.00 29.14 A O ATOM 4444 N CYS A 295 55.322 −12.912 −8.517 1.00 26.55 A N ATOM 4445 CA CYS A 295 54.540 −13.511 −7.464 1.00 27.07 A C ATOM 4447 CB CYS A 295 54.524 −15.043 −7.567 1.00 28.06 A C ATOM 4450 SG CYS A 295 53.328 −15.810 −6.436 1.00 26.81 A S ATOM 4452 C CYS A 295 55.044 −13.060 −6.100 1.00 25.39 A C ATOM 4453 O CYS A 295 54.254 −12.597 −5.284 1.00 26.37 A O ATOM 4455 N ARG A 296 56.345 −13.169 −5.861 1.00 24.67 A N ATOM 4456 CA ARG A 296 56.923 −12.732 −4.592 1.00 24.65 A C ATOM 4458 CB ARG A 296 58.437 −12.963 −4.543 1.00 25.23 A C ATOM 4461 CG ARG A 296 58.835 −14.418 −4.502 1.00 22.91 A C ATOM 4464 CD ARG A 296 60.318 −14.618 −4.304 1.00 19.82 A C ATOM 4467 NE ARG A 296 61.076 −14.305 −5.507 1.00 19.18 A N ATOM 4469 CZ ARG A 296 61.223 −15.096 −6.561 1.00 22.17 A C ATOM 4470 NH1 ARG A 296 60.647 −16.274 −6.620 1.00 26.97 A N ATOM 4473 NH2 ARG A 296 61.933 −14.676 −7.592 1.00 26.83 A N ATOM 4476 C ARG A 296 56.651 −11.249 −4.321 1.00 24.07 A C ATOM 4477 O ARG A 296 56.264 −10.893 −3.221 1.00 24.88 A O ATOM 4479 N ASN A 297 56.849 −10.408 −5.325 1.00 23.19 A N ATOM 4480 CA ASN A 297 56.624 −8.982 −5.192 1.00 24.62 A C ATOM 4482 CB ASN A 297 57.063 −8.215 −6.463 1.00 25.20 A C ATOM 4485 CG ASN A 297 58.598 −8.235 −6.676 1.00 30.05 A C ATOM 4486 OD1 ASN A 297 59.359 −8.502 −5.753 1.00 36.93 A O ATOM 4487 ND2 ASN A 297 59.039 −7.959 −7.903 1.00 25.92 A N ATOM 4490 C ASN A 297 55.152 −8.696 −4.866 1.00 24.78 A C ATOM 4491 O ASN A 297 54.871 −7.960 −3.926 1.00 22.91 A O ATOM 4493 N SER A 298 54.236 −9.305 −5.613 1.00 23.57 A N ATOM 4494 CA SER A 298 52.813 −9.173 −5.338 1.00 25.11 A C ATOM 4496 CB SER A 298 51.968 −10.060 −6.272 1.00 24.10 A C ATOM 4499 OG SER A 298 51.678 −9.429 −7.493 1.00 32.64 A O ATOM 4501 C SER A 298 52.475 −9.579 −3.916 1.00 22.38 A C ATOM 4502 O SER A 298 51.809 −8.846 −3.192 1.00 24.02 A O ATOM 4504 N VAL A 299 52.857 −10.791 −3.552 1.00 21.05 A N ATOM 4505 CA VAL A 299 52.520 −11.321 −2.237 1.00 20.22 A C ATOM 4507 CB VAL A 299 52.949 −12.794 −2.091 1.00 20.34 A C ATOM 4509 CG1 VAL A 299 52.838 −13.258 −0.650 1.00 22.69 A C ATOM 4513 CG2 VAL A 299 52.089 −13.647 −2.954 1.00 18.14 A C ATOM 4517 C VAL A 299 53.124 −10.468 −1.133 1.00 19.72 A C ATOM 4518 O VAL A 299 52.466 −10.220 −0.122 1.00 21.66 A O ATOM 4520 N ALA A 300 54.342 −9.970 −1.342 1.00 19.58 A N ATOM 4521 CA ALA A 300 55.011 −9.150 −0.320 1.00 21.43 A C ATOM 4523 CB ALA A 300 56.486 −8.987 −0.667 1.00 19.80 A C ATOM 4527 C ALA A 300 54.339 −7.779 −0.181 1.00 21.64 A C ATOM 4528 O ALA A 300 54.232 −7.202 0.922 1.00 21.71 A O ATOM 4530 N LYS A 301 53.872 −7.255 −1.303 1.00 22.14 A N ATOM 4531 CA LYS A 301 53.204 −5.964 −1.281 1.00 21.36 A C ATOM 4533 CB LYS A 301 52.984 −5.439 −2.690 1.00 20.86 A C ATOM 4536 CG LYS A 301 54.236 −4.921 −3.366 1.00 19.27 A C ATOM 4539 CD LYS A 301 53.965 −4.388 −4.792 1.00 19.50 A C ATOM 4542 CE LYS A 301 55.276 −3.879 −5.400 1.00 29.29 A C ATOM 4545 NZ LYS A 301 55.116 −3.235 −6.741 1.00 34.09 A N ATOM 4549 C LYS A 301 51.879 −6.131 −0.548 1.00 21.48 A C ATOM 4550 O LYS A 301 51.540 −5.352 0.338 1.00 22.68 A O ATOM 4552 N MET A 302 51.160 −7.192 −0.878 1.00 20.39 A N ATOM 4553 CA MET A 302 49.849 −7.409 −0.282 1.00 20.92 A C ATOM 4555 CB MET A 302 49.133 −8.583 −0.969 1.00 20.09 A C ATOM 4558 CG MET A 302 48.712 −8.266 −2.405 1.00 19.65 A C ATOM 4561 SD MET A 302 47.843 −6.709 −2.587 1.00 28.88 A S ATOM 4562 CE MET A 302 49.185 −5.629 −3.034 1.00 23.45 A C ATOM 4566 C MET A 302 49.937 −7.677 1.199 1.00 22.54 A C ATOM 4567 O MET A 302 49.185 −7.097 1.998 1.00 24.84 A O ATOM 4569 N PHE A 303 50.861 −8.551 1.579 1.00 22.29 A N ATOM 4570 CA PHE A 303 51.019 −8.862 2.982 1.00 22.99 A C ATOM 4572 CB PHE A 303 51.984 −10.050 3.159 1.00 25.28 A C ATOM 4575 CG PHE A 303 51.716 −10.891 4.387 1.00 30.30 A C ATOM 4576 CD1 PHE A 303 50.589 −10.683 5.192 1.00 34.42 A C ATOM 4578 CE1 PHE A 303 50.371 −11.460 6.324 1.00 42.97 A C ATOM 4580 CZ PHE A 303 51.274 −12.459 6.657 1.00 41.14 A C ATOM 4582 CE2 PHE A 303 52.381 −12.678 5.871 1.00 34.43 A C ATOM 4584 CD2 PHE A 303 52.599 −11.899 4.741 1.00 36.11 A C ATOM 4586 C PHE A 303 51.455 −7.625 3.816 1.00 21.77 A C ATOM 4587 O PHE A 303 51.033 −7.464 4.938 1.00 23.38 A O ATOM 4589 N SER A 304 52.270 −6.755 3.244 1.00 20.77 A N ATOM 4590 CA SER A 304 52.648 −5.517 3.876 1.00 21.72 A C ATOM 4592 CB SER A 304 53.638 −4.750 2.997 1.00 24.31 A C ATOM 4595 OG SER A 304 54.847 −5.480 2.795 1.00 28.25 A O ATOM 4597 C SER A 304 51.440 −4.622 4.150 1.00 23.63 A C ATOM 4598 O SER A 304 51.387 −4.005 5.212 1.00 24.50 A O ATOM 4600 N PHE A 305 50.497 −4.541 3.205 1.00 23.27 A N ATOM 4601 CA PHE A 305 49.230 −3.804 3.424 1.00 21.89 A C ATOM 4603 CB PHE A 305 48.466 −3.560 2.113 1.00 22.71 A C ATOM 4606 CG PHE A 305 48.938 −2.345 1.368 1.00 20.52 A C ATOM 4607 CD1 PHE A 305 48.659 −1.073 1.850 1.00 24.16 A C ATOM 4609 CE1 PHE A 305 49.097 0.050 1.181 1.00 23.31 A C ATOM 4611 CZ PHE A 305 49.826 −0.078 0.013 1.00 23.43 A C ATOM 4613 CE2 PHE A 305 50.120 −1.337 −0.478 1.00 29.03 A C ATOM 4615 CD2 PHE A 305 49.682 −2.469 0.219 1.00 22.45 A C ATOM 4617 C PHE A 305 48.313 −4.499 4.393 1.00 20.95 A C ATOM 4618 O PHE A 305 47.674 −3.849 5.226 1.00 20.99 A O ATOM 4620 N VAL A 306 48.255 −5.821 4.309 1.00 20.76 A N ATOM 4621 CA VAL A 306 47.434 −6.575 5.229 1.00 19.75 A C ATOM 4623 CB VAL A 306 47.506 −8.080 4.963 1.00 22.66 A C ATOM 4625 CG1 VAL A 306 46.885 −8.886 6.091 1.00 16.37 A C ATOM 4629 CG2 VAL A 306 46.790 −8.388 3.645 1.00 21.60 A C ATOM 4633 C VAL A 306 47.823 −6.224 6.636 1.00 22.33 A C ATOM 4634 O VAL A 306 46.962 −5.861 7.435 1.00 24.20 A O ATOM 4636 N THR A 307 49.108 −6.225 6.945 1.00 24.63 A N ATOM 4637 CA THR A 307 49.502 −6.040 8.344 1.00 26.20 A C ATOM 4639 CB THR A 307 51.009 −6.313 8.570 1.00 26.67 A C ATOM 4641 OG1 THR A 307 51.771 −5.398 7.828 1.00 36.85 A O ATOM 4643 CG2 THR A 307 51.386 −7.698 8.106 1.00 31.58 A C ATOM 4647 C THR A 307 49.092 −4.669 8.895 1.00 25.04 A C ATOM 4648 O THR A 307 48.668 −4.547 10.049 1.00 26.45 A O ATOM 4650 N ILE A 308 49.172 −3.647 8.060 1.00 23.77 A N ATOM 4651 CA ILE A 308 48.761 −2.299 8.445 1.00 23.18 A C ATOM 4653 CB ILE A 308 49.219 −1.270 7.409 1.00 24.44 A C ATOM 4655 CG1 ILE A 308 50.742 −1.206 7.371 1.00 29.53 A C ATOM 4658 CD1 ILE A 308 51.267 −0.355 6.265 1.00 30.91 A C ATOM 4662 CG2 ILE A 308 48.639 0.078 7.714 1.00 23.42 A C ATOM 4666 C ILE A 308 47.252 −2.223 8.554 1.00 20.59 A C ATOM 4667 O ILE A 308 46.723 −1.650 9.506 1.00 20.09 A O ATOM 4669 N ILE A 309 46.551 −2.802 7.585 1.00 20.24 A N ATOM 4670 CA ILE A 309 45.093 −2.712 7.594 1.00 22.80 A C ATOM 4672 CB ILE A 309 44.466 −3.173 6.284 1.00 24.10 A C ATOM 4674 CG1 ILE A 309 44.927 −2.279 5.128 1.00 25.79 A C ATOM 4677 CD1 ILE A 309 44.234 −1.018 5.079 1.00 37.61 A C ATOM 4681 CG2 ILE A 309 42.941 −3.162 6.360 1.00 17.79 A C ATOM 4685 C ILE A 309 44.584 −3.521 8.777 1.00 23.44 A C ATOM 4686 O ILE A 309 43.626 −3.118 9.447 1.00 23.95 A O ATOM 4688 N ASP A 310 45.278 −4.617 9.076 1.00 24.85 A N ATOM 4689 CA ASP A 310 44.942 −5.453 10.226 1.00 25.67 A C ATOM 4691 CB ASP A 310 45.823 −6.716 10.278 1.00 29.93 A C ATOM 4694 CG ASP A 310 45.316 −7.775 11.294 1.00 34.30 A C ATOM 4695 OD1 ASP A 310 44.106 −7.830 11.573 1.00 46.69 A O ATOM 4696 OD2 ASP A 310 46.139 −8.566 11.790 1.00 50.27 A O ATOM 4697 C ASP A 310 45.084 −4.658 11.501 1.00 23.92 A C ATOM 4698 O ASP A 310 44.202 −4.696 12.344 1.00 23.74 A O ATOM 4700 N ASP A 311 46.167 −3.903 11.648 1.00 23.61 A N ATOM 4701 CA ASP A 311 46.302 −3.063 12.840 1.00 24.15 A C ATOM 4703 CB ASP A 311 47.653 −2.346 12.864 1.00 25.79 A C ATOM 4706 CG ASP A 311 48.811 −3.283 13.157 1.00 33.35 A C ATOM 4707 OD1 ASP A 311 48.578 −4.327 13.802 1.00 37.00 A O ATOM 4708 OD2 ASP A 311 49.951 −2.976 12.720 1.00 42.12 A O ATOM 4709 C ASP A 311 45.185 −2.013 12.963 1.00 22.01 A C ATOM 4710 O ASP A 311 44.750 −1.689 14.066 1.00 20.06 A O ATOM 4712 N ILE A 312 44.738 −1.486 11.827 1.00 20.61 A N ATOM 4713 CA ILE A 312 43.693 −0.467 11.814 1.00 20.98 A C ATOM 4715 CB ILE A 312 43.462 0.111 10.392 1.00 20.72 A C ATOM 4717 CG1 ILE A 312 44.605 1.043 10.000 1.00 19.24 A C ATOM 4720 CD1 ILE A 312 44.576 1.481 8.508 1.00 18.67 A C ATOM 4724 CG2 ILE A 312 42.163 0.844 10.337 1.00 17.52 A C ATOM 4728 C ILE A 312 42.403 −1.049 12.373 1.00 21.29 A C ATOM 4729 O ILE A 312 41.781 −0.462 13.259 1.00 22.89 A O ATOM 4731 N TYR A 313 42.036 −2.232 11.905 1.00 21.99 A N ATOM 4732 CA TYR A 313 40.816 −2.852 12.362 1.00 22.07 A C ATOM 4734 CB TYR A 313 40.395 −3.962 11.408 1.00 21.44 A C ATOM 4737 CG TYR A 313 39.668 −3.483 10.187 1.00 17.68 A C ATOM 4738 CD1 TYR A 313 38.273 −3.567 10.095 1.00 17.60 A C ATOM 4740 CE1 TYR A 313 37.601 −3.157 8.927 1.00 18.93 A C ATOM 4742 CZ TYR A 313 38.333 −2.642 7.866 1.00 20.93 A C ATOM 4743 OH TYR A 313 37.713 −2.225 6.703 1.00 21.19 A O ATOM 4745 CE2 TYR A 313 39.705 −2.556 7.953 1.00 21.64 A C ATOM 4747 CD2 TYR A 313 40.361 −2.958 9.111 1.00 20.65 A C ATOM 4749 C TYR A 313 40.929 −3.399 13.761 1.00 24.20 A C ATOM 4750 O TYR A 313 39.957 −3.362 14.526 1.00 25.90 A O ATOM 4752 N ASP A 314 42.119 −3.872 14.108 1.00 26.32 A N ATOM 4753 CA ASP A 314 42.339 −4.552 15.395 1.00 27.33 A C ATOM 4755 CB ASP A 314 43.622 −5.398 15.321 1.00 29.31 A C ATOM 4758 CG ASP A 314 43.891 −6.217 16.598 1.00 33.13 A C ATOM 4759 OD1 ASP A 314 42.985 −6.889 17.107 1.00 38.25 A O ATOM 4760 OD2 ASP A 314 45.038 −6.219 17.065 1.00 42.87 A O ATOM 4761 C ASP A 314 42.415 −3.565 16.560 1.00 25.83 A C ATOM 4762 O ASP A 314 41.786 −3.798 17.589 1.00 24.11 A O ATOM 4764 N VAL A 315 43.168 −2.469 16.419 1.00 25.13 A N ATOM 4765 CA VAL A 315 43.388 −1.571 17.581 1.00 23.81 A C ATOM 4767 CB VAL A 315 44.803 −1.707 18.175 1.00 24.08 A C ATOM 4769 CG1 VAL A 315 44.920 −3.047 18.917 1.00 27.01 A C ATOM 4773 CG2 VAL A 315 45.876 −1.542 17.111 1.00 18.89 A C ATOM 4777 C VAL A 315 43.121 −0.091 17.390 1.00 24.28 A C ATOM 4778 O VAL A 315 42.626 0.550 18.316 1.00 25.60 A O ATOM 4780 N TYR A 316 43.452 0.454 16.218 1.00 23.17 A N ATOM 4781 CA TYR A 316 43.463 1.888 16.012 1.00 22.03 A C ATOM 4783 CB TYR A 316 44.468 2.250 14.921 1.00 24.42 A C ATOM 4786 CG TYR A 316 44.780 3.741 14.847 1.00 24.19 A C ATOM 4787 CD1 TYR A 316 45.669 4.330 15.734 1.00 22.67 A C ATOM 4789 CE1 TYR A 316 45.956 5.710 15.664 1.00 26.80 A C ATOM 4791 CZ TYR A 316 45.343 6.487 14.689 1.00 23.98 A C ATOM 4792 OH TYR A 316 45.616 7.825 14.594 1.00 23.58 A O ATOM 4794 CE2 TYR A 316 44.462 5.915 13.802 1.00 27.54 A C ATOM 4796 CD2 TYR A 316 44.188 4.553 13.880 1.00 23.46 A C ATOM 4798 C TYR A 316 42.109 2.489 15.659 1.00 21.60 A C ATOM 4799 O TYR A 316 41.709 3.471 16.256 1.00 21.67 A O ATOM 4801 N GLY A 317 41.407 1.917 14.684 1.00 22.29 A N ATOM 4802 CA GLY A 317 40.150 2.510 14.186 1.00 21.66 A C ATOM 4805 C GLY A 317 38.877 2.302 15.016 1.00 22.48 A C ATOM 4806 O GLY A 317 38.613 1.212 15.566 1.00 20.21 A O ATOM 4808 N THR A 318 38.050 3.335 15.090 1.00 21.00 A N ATOM 4809 CA THR A 318 36.756 3.163 15.737 1.00 22.14 A C ATOM 4811 CB THR A 318 36.126 4.472 16.125 1.00 20.46 A C ATOM 4813 OG1 THR A 318 35.835 5.197 14.935 1.00 20.90 A O ATOM 4815 CG2 THR A 318 37.073 5.280 17.008 1.00 21.19 A C ATOM 4819 C THR A 318 35.844 2.436 14.759 1.00 21.63 A C ATOM 4820 O THR A 318 36.110 2.395 13.550 1.00 21.76 A O ATOM 4822 N LEU A 319 34.777 1.864 15.297 1.00 20.18 A N ATOM 4823 CA LEU A 319 33.830 1.067 14.514 1.00 22.24 A C ATOM 4825 CB LEU A 319 32.701 0.551 15.416 1.00 22.04 A C ATOM 4828 CG LEU A 319 32.239 −0.897 15.249 1.00 31.30 A C ATOM 4830 CD1 LEU A 319 33.410 −1.842 15.024 1.00 25.53 A C ATOM 4834 CD2 LEU A 319 31.421 −1.339 16.464 1.00 34.06 A C ATOM 4838 C LEU A 319 33.258 1.867 13.347 1.00 23.17 A C ATOM 4839 O LEU A 319 33.195 1.361 12.226 1.00 23.56 A O ATOM 4841 N ASP A 320 32.877 3.118 13.610 1.00 23.84 A N ATOM 4842 CA ASP A 320 32.388 4.035 12.580 1.00 26.41 A C ATOM 4844 CB ASP A 320 31.999 5.411 13.174 1.00 28.62 A C ATOM 4847 CG ASP A 320 30.753 5.370 14.089 1.00 34.92 A C ATOM 4848 OD1 ASP A 320 29.889 4.480 13.934 1.00 40.85 A O ATOM 4849 OD2 ASP A 320 30.633 6.273 14.960 1.00 45.71 A O ATOM 4850 C ASP A 320 33.454 4.260 11.490 1.00 25.67 A C ATOM 4851 O ASP A 320 33.133 4.313 10.319 1.00 26.46 A O ATOM 4853 N GLU A 321 34.713 4.420 11.879 1.00 24.15 A N ATOM 4854 CA GLU A 321 35.787 4.613 10.895 1.00 22.51 A C ATOM 4856 CB GLU A 321 37.102 4.984 11.579 1.00 21.98 A C ATOM 4859 CG GLU A 321 37.114 6.354 12.250 1.00 22.24 A C ATOM 4862 CD GLU A 321 38.425 6.622 13.009 1.00 26.20 A C ATOM 4863 OE1 GLU A 321 39.060 5.664 13.490 1.00 22.42 A O ATOM 4864 OE2 GLU A 321 38.823 7.795 13.126 1.00 26.34 A O ATOM 4865 C GLU A 321 35.997 3.346 10.075 1.00 22.83 A C ATOM 4866 O GLU A 321 36.239 3.410 8.869 1.00 20.72 A O ATOM 4868 N LEU A 322 35.902 2.191 10.735 1.00 21.58 A N ATOM 4869 CA LEU A 322 36.126 0.944 10.053 1.00 21.00 A C ATOM 4871 CB LEU A 322 36.303 −0.196 11.051 1.00 20.31 A C ATOM 4874 CG LEU A 322 37.454 −0.038 12.044 1.00 21.17 A C ATOM 4876 CD1 LEU A 322 37.523 −1.242 12.977 1.00 21.39 A C ATOM 4880 CD2 LEU A 322 38.778 0.167 11.355 1.00 21.53 A C ATOM 4884 C LEU A 322 34.998 0.636 9.065 1.00 22.33 A C ATOM 4885 O LEU A 322 35.233 −0.029 8.055 1.00 23.58 A O ATOM 4887 N GLU A 323 33.784 1.099 9.351 1.00 23.50 A N ATOM 4888 CA GLU A 323 32.687 0.991 8.396 1.00 23.70 A C ATOM 4890 CB GLU A 323 31.342 1.418 9.002 1.00 25.90 A C ATOM 4893 CG GLU A 323 30.728 0.464 10.031 1.00 31.83 A C ATOM 4896 CD GLU A 323 29.981 −0.734 9.421 1.00 38.05 A C ATOM 4897 OE1 GLU A 323 29.503 −1.575 10.218 1.00 40.48 A O ATOM 4898 OE2 GLU A 323 29.875 −0.839 8.170 1.00 39.62 A O ATOM 4899 C GLU A 323 32.991 1.873 7.193 1.00 23.25 A C ATOM 4900 O GLU A 323 32.756 1.466 6.043 1.00 20.74 A O ATOM 4902 N LEU A 324 33.507 3.082 7.434 1.00 22.29 A N ATOM 4903 CA LEU A 324 33.832 3.961 6.302 1.00 23.80 A C ATOM 4905 CB LEU A 324 34.286 5.340 6.768 1.00 25.06 A C ATOM 4908 CG LEU A 324 33.225 6.246 7.386 1.00 30.71 A C ATOM 4910 CD1 LEU A 324 33.874 7.501 8.031 1.00 27.53 A C ATOM 4914 CD2 LEU A 324 32.178 6.642 6.330 1.00 32.67 A C ATOM 4918 C LEU A 324 34.888 3.306 5.399 1.00 22.01 A C ATOM 4919 O LEU A 324 34.739 3.259 4.180 1.00 23.37 A O ATOM 4921 N PHE A 325 35.916 2.736 6.003 1.00 21.76 A N ATOM 4922 CA PHE A 325 36.998 2.111 5.239 1.00 21.09 A C ATOM 4924 CB PHE A 325 38.125 1.683 6.176 1.00 20.33 A C ATOM 4927 CG PHE A 325 39.389 1.362 5.465 1.00 18.41 A C ATOM 4928 CD1 PHE A 325 40.259 2.364 5.107 1.00 19.45 A C ATOM 4930 CE1 PHE A 325 41.431 2.078 4.437 1.00 17.94 A C ATOM 4932 CZ PHE A 325 41.746 0.809 4.112 1.00 18.28 A C ATOM 4934 CE2 PHE A 325 40.879 −0.223 4.450 1.00 27.60 A C ATOM 4936 CD2 PHE A 325 39.702 0.070 5.143 1.00 19.26 A C ATOM 4938 C PHE A 325 36.516 0.919 4.430 1.00 19.97 A C ATOM 4939 O PHE A 325 36.797 0.802 3.238 1.00 19.86 A O ATOM 4941 N THR A 326 35.785 0.036 5.094 1.00 21.26 A N ATOM 4942 CA THR A 326 35.189 −1.144 4.453 1.00 20.87 A C ATOM 4944 CB THR A 326 34.294 −1.897 5.435 1.00 21.86 A C ATOM 4946 OG1 THR A 326 35.065 −2.222 6.594 1.00 24.18 A O ATOM 4948 CG2 THR A 326 33.754 −3.180 4.828 1.00 15.64 A C ATOM 4952 C THR A 326 34.364 −0.770 3.234 1.00 21.47 A C ATOM 4953 O THR A 326 34.581 −1.306 2.146 1.00 20.27 A O ATOM 4955 N ASP A 327 33.454 0.183 3.422 1.00 23.46 A N ATOM 4956 CA ASP A 327 32.624 0.717 2.342 1.00 24.01 A C ATOM 4958 CB ASP A 327 31.644 1.747 2.914 1.00 24.35 A C ATOM 4961 CG ASP A 327 30.821 2.461 1.837 1.00 33.07 A C ATOM 4962 OD1 ASP A 327 29.907 1.827 1.249 1.00 35.22 A O ATOM 4963 OD2 ASP A 327 31.080 3.674 1.594 1.00 39.61 A O ATOM 4964 C ASP A 327 33.486 1.322 1.210 1.00 24.37 A C ATOM 4965 O ASP A 327 33.203 1.124 0.026 1.00 24.49 A O ATOM 4967 N ALA A 328 34.547 2.038 1.568 1.00 23.77 A N ATOM 4968 CA ALA A 328 35.410 2.652 0.559 1.00 21.98 A C ATOM 4970 CB ALA A 328 36.444 3.553 1.211 1.00 20.52 A C ATOM 4974 C ALA A 328 36.101 1.571 −0.290 1.00 20.95 A C ATOM 4975 O ALA A 328 36.252 1.727 −1.498 1.00 19.89 A O ATOM 4977 N VAL A 329 36.504 0.475 0.341 1.00 19.74 A N ATOM 4978 CA VAL A 329 37.136 −0.623 −0.385 1.00 18.98 A C ATOM 4980 CB VAL A 329 37.802 −1.638 0.563 1.00 18.57 A C ATOM 4982 CG1 VAL A 329 38.961 −0.957 1.330 1.00 15.41 A C ATOM 4986 CG2 VAL A 329 38.301 −2.860 −0.184 1.00 19.70 A C ATOM 4990 C VAL A 329 36.100 −1.269 −1.289 1.00 21.12 A C ATOM 4991 O VAL A 329 36.383 −1.524 −2.448 1.00 23.23 A O ATOM 4993 N GLU A 330 34.882 −1.455 −0.799 1.00 22.69 A N ATOM 4994 CA GLU A 330 33.828 −2.078 −1.610 1.00 24.26 A C ATOM 4996 CB GLU A 330 32.564 −2.299 −0.789 1.00 24.45 A C ATOM 4999 CG GLU A 330 32.659 −3.424 0.254 1.00 32.15 A C ATOM 5002 CD GLU A 330 31.415 −3.522 1.181 1.00 37.11 A C ATOM 5003 OE1 GLU A 330 31.335 −4.497 1.946 1.00 41.56 A O ATOM 5004 OE2 GLU A 330 30.536 −2.629 1.162 1.00 37.97 A O ATOM 5005 C GLU A 330 33.484 −1.252 −2.842 1.00 24.43 A C ATOM 5006 O GLU A 330 33.372 −1.785 −3.931 1.00 23.22 A O ATOM 5008 N ARG A 331 33.305 0.048 −2.659 1.00 24.59 A N ATOM 5009 CA AARG A 331 32.926 0.933 −3.762 0.50 25.42 A C ATOM 5010 CA BARG A 331 32.924 0.934 −3.762 0.50 25.53 A C ATOM 5013 CB AARG A 331 32.331 2.240 −3.217 0.50 25.39 A C ATOM 5014 CB BARG A 331 32.311 2.238 −3.215 0.50 25.60 A C ATOM 5019 CG AARG A 331 30.912 2.068 −2.616 0.50 29.35 A C ATOM 5020 CG BARG A 331 31.013 1.984 −2.402 0.50 30.09 A C ATOM 5025 CD AARG A 331 30.467 3.348 −1.936 0.50 31.41 A C ATOM 5026 CD BARG A 331 30.354 3.255 −1.877 0.50 32.13 A C ATOM 5031 NE AARG A 331 31.254 4.455 −2.460 0.50 36.48 A N ATOM 5032 NE BARG A 331 29.105 3.539 −2.578 0.50 39.36 A N ATOM 5035 CZ AARG A 331 32.146 5.140 −1.754 0.50 36.08 A C ATOM 5036 CZ BARG A 331 27.909 3.144 −2.156 0.50 40.76 A C ATOM 5037 NH1 AARG A 331 32.820 6.106 −2.332 0.50 37.83 A N ATOM 5038 NH1 BARG A 331 27.798 2.459 −1.027 0.50 40.70 A N ATOM 5043 NH2 AARG A 331 32.348 4.880 −0.471 0.50 33.30 A N ATOM 5044 NH2 BARG A 331 26.824 3.439 −2.854 0.50 39.88 A N ATOM 5049 C ARG A 331 34.092 1.210 −4.719 1.00 24.63 A C ATOM 5050 O ARG A 331 33.886 1.403 −5.905 1.00 25.83 A O ATOM 5052 N TRP A 332 35.315 1.224 −4.198 1.00 23.38 A N ATOM 5053 CA TRP A 332 36.540 1.354 −5.008 1.00 22.12 A C ATOM 5055 CB TRP A 332 36.827 0.035 −5.797 1.00 22.05 A C ATOM 5058 CG TRP A 332 38.233 −0.101 −6.263 1.00 19.00 A C ATOM 5059 CD1 TRP A 332 38.704 0.112 −7.524 1.00 20.39 A C ATOM 5061 NE1 TRP A 332 40.077 −0.096 −7.562 1.00 21.23 A N ATOM 5063 CE2 TRP A 332 40.509 −0.451 −6.312 1.00 14.45 A C ATOM 5064 CD2 TRP A 332 39.381 −0.461 −5.462 1.00 22.97 A C ATOM 5065 CE3 TRP A 332 39.558 −0.801 −4.120 1.00 19.44 A C ATOM 5067 CZ3 TRP A 332 40.841 −1.098 −3.666 1.00 21.88 A C ATOM 5069 CH2 TRP A 332 41.936 −1.073 −4.536 1.00 23.07 A C ATOM 5071 CZ2 TRP A 332 41.787 −0.751 −5.859 1.00 27.36 A C ATOM 5073 C TRP A 332 36.468 2.569 −5.923 1.00 21.31 A C ATOM 5074 O TRP A 332 36.673 2.481 −7.133 1.00 21.30 A O ATOM 5076 N ASP A 333 36.203 3.715 −5.311 1.00 23.84 A N ATOM 5077 CA ASP A 333 35.996 4.962 −6.028 1.00 25.51 A C ATOM 5079 CB ASP A 333 34.525 5.365 −5.884 1.00 28.49 A C ATOM 5082 CG ASP A 333 34.207 6.764 −6.429 1.00 31.34 A C ATOM 5083 OD1 ASP A 333 35.061 7.438 −7.055 1.00 37.88 A O ATOM 5084 OD2 ASP A 333 33.054 7.180 −6.224 1.00 35.04 A O ATOM 5085 C ASP A 333 36.901 6.000 −5.408 1.00 25.74 A C ATOM 5086 O ASP A 333 36.638 6.473 −4.315 1.00 27.33 A O ATOM 5088 N VAL A 334 37.950 6.377 −6.131 1.00 25.22 A N ATOM 5089 CA VAL A 334 38.913 7.315 −5.629 1.00 24.40 A C ATOM 5091 CB VAL A 334 40.154 7.336 −6.508 1.00 23.40 A C ATOM 5093 CG1 VAL A 334 41.277 8.090 −5.851 1.00 22.78 A C ATOM 5097 CG2 VAL A 334 39.839 7.911 −7.873 1.00 22.06 A C ATOM 5101 C VAL A 334 38.336 8.721 −5.512 1.00 28.91 A C ATOM 5102 O VAL A 334 38.857 9.535 −4.750 1.00 29.34 A O ATOM 5104 N ASN A 335 37.261 9.015 −6.246 1.00 30.93 A N ATOM 5105 CA ASN A 335 36.668 10.356 −6.204 1.00 32.90 A C ATOM 5107 CB ASN A 335 35.767 10.617 −7.430 1.00 33.01 A C ATOM 5110 CG ASN A 335 36.539 10.559 −8.768 1.00 35.09 A C ATOM 5111 OD1 ASN A 335 37.513 11.293 −8.972 1.00 31.46 A O ATOM 5112 ND2 ASN A 335 36.080 9.693 −9.690 1.00 29.46 A N ATOM 5115 C ASN A 335 35.889 10.616 −4.916 1.00 35.23 A C ATOM 5116 O ASN A 335 35.438 11.744 −4.718 1.00 37.55 A O ATOM 5118 N ALA A 336 35.737 9.588 −4.062 1.00 36.18 A N ATOM 5119 CA ALA A 336 35.107 9.702 −2.717 1.00 38.28 A C ATOM 5121 CB ALA A 336 33.972 8.678 −2.600 1.00 37.37 A O ATOM 5125 C ALA A 336 36.067 9.540 −1.501 1.00 38.39 A C ATOM 5126 O ALA A 336 35.632 9.516 −0.357 1.00 40.53 A O ATOM 5128 N ILE A 337 37.357 9.392 −1.766 1.00 39.34 A N ATOM 5129 CA ILE A 337 38.442 9.438 −0.767 1.00 39.49 A C ATOM 5131 CB ILE A 337 39.770 9.736 −1.552 1.00 41.71 A C ATOM 5133 CG1 ILE A 337 41.026 9.661 −0.714 1.00 45.87 A C ATOM 5136 CD1 ILE A 337 42.218 10.171 −1.518 1.00 45.13 A C ATOM 5140 CG2 ILE A 337 39.745 11.124 −2.199 1.00 40.01 A C ATOM 5144 C ILE A 337 38.231 10.470 0.388 1.00 41.00 A C ATOM 5145 O ILE A 337 38.497 10.165 1.550 1.00 41.18 A O ATOM 5147 N ASN A 338 37.726 11.667 0.070 1.00 39.57 A N ATOM 5148 CA ASN A 338 37.503 12.723 1.064 1.00 39.05 A C ATOM 5150 CB ASN A 338 37.154 14.057 0.369 1.00 38.88 A C ATOM 5153 CG ASN A 338 38.379 14.735 −0.240 1.00 38.68 A C ATOM 5154 OD1 ASN A 338 39.518 14.355 0.056 1.00 37.66 A O ATOM 5155 ND2 ASN A 338 38.154 15.740 −1.091 1.00 32.26 A N ATOM 5158 C ASN A 338 36.484 12.420 2.180 1.00 38.52 A C ATOM 5159 O ASN A 338 36.443 13.142 3.179 1.00 36.24 A O ATOM 5161 N ASP A 339 35.695 11.360 2.017 1.00 37.68 A N ATOM 5162 CA ASP A 339 34.804 10.866 3.080 1.00 38.81 A C ATOM 5164 CB ASP A 339 33.943 9.699 2.546 1.00 41.47 A C ATOM 5167 CG ASP A 339 32.967 10.110 1.435 1.00 45.43 A C ATOM 5168 OD1 ASP A 339 32.684 11.323 1.284 1.00 49.71 A O ATOM 5169 OD2 ASP A 339 32.466 9.191 0.738 1.00 42.53 A O ATOM 5170 C ASP A 339 35.566 10.336 4.319 1.00 36.47 A C ATOM 5171 O ASP A 339 35.045 10.344 5.440 1.00 37.33 A O ATOM 5173 N LEU A 340 36.777 9.835 4.088 1.00 31.99 A N ATOM 5174 CA LEU A 340 37.551 9.126 5.099 1.00 28.85 A C ATOM 5176 CB LEU A 340 38.562 8.206 4.419 1.00 26.83 A C ATOM 5179 CG LEU A 340 38.040 7.105 3.512 1.00 26.05 A C ATOM 5181 CD1 LEU A 340 39.177 6.481 2.697 1.00 19.73 A C ATOM 5185 CD2 LEU A 340 37.335 6.075 4.347 1.00 28.12 A C ATOM 5189 C LEU A 340 38.342 10.102 5.973 1.00 27.33 A C ATOM 5190 O LEU A 340 38.664 11.198 5.525 1.00 28.68 A O ATOM 5192 N PRO A 341 38.698 9.681 7.199 1.00 24.34 A N ATOM 5193 CA PRO A 341 39.596 10.458 8.061 1.00 24.84 A C ATOM 5195 CB PRO A 341 39.422 9.801 9.439 1.00 26.28 A C ATOM 5198 CG PRO A 341 38.974 8.411 9.152 1.00 25.66 A C ATOM 5201 CD PRO A 341 38.256 8.427 7.838 1.00 23.02 A C ATOM 5204 C PRO A 341 41.037 10.361 7.585 1.00 23.92 A C ATOM 5205 O PRO A 341 41.409 9.379 6.966 1.00 23.65 A O ATOM 5206 N ASP A 342 41.835 11.381 7.878 1.00 24.01 A N ATOM 5207 CA ASP A 342 43.159 11.568 7.257 1.00 24.20 A C ATOM 5209 CB ASP A 342 43.956 12.647 8.021 1.00 24.30 A C ATOM 5212 CG ASP A 342 43.410 14.066 7.807 1.00 32.75 A C ATOM 5213 OD1 ASP A 342 42.564 14.253 6.896 1.00 33.36 A O ATOM 5214 OD2 ASP A 342 43.842 14.998 8.548 1.00 38.90 A O ATOM 5215 C ASP A 342 44.009 10.276 7.125 1.00 23.76 A C ATOM 5216 O ASP A 342 44.523 9.958 6.030 1.00 23.73 A O ATOM 5218 N TYR A 343 44.148 9.524 8.216 1.00 21.13 A N ATOM 5219 CA TYR A 343 45.020 8.355 8.192 1.00 20.93 A C ATOM 5221 CB TYR A 343 45.222 7.786 9.584 1.00 20.26 A C ATOM 5224 CG TYR A 343 44.066 7.002 10.157 1.00 23.08 A C ATOM 5225 CD1 TYR A 343 43.048 7.626 10.855 1.00 18.13 A C ATOM 5227 CE1 TYR A 343 42.009 6.903 11.384 1.00 27.05 A C ATOM 5229 CZ TYR A 343 41.994 5.521 11.239 1.00 24.51 A C ATOM 5230 OH TYR A 343 40.978 4.744 11.763 1.00 27.02 A O ATOM 5232 CE2 TYR A 343 43.012 4.892 10.571 1.00 23.11 A C ATOM 5234 CD2 TYR A 343 44.034 5.625 10.048 1.00 21.57 A C ATOM 5236 C TYR A 343 44.515 7.299 7.210 1.00 21.42 A C ATOM 5237 O TYR A 343 45.303 6.590 6.572 1.00 20.42 A O ATOM 5239 N MET A 344 43.204 7.235 7.053 1.00 20.78 A N ATOM 5240 CA MET A 344 42.599 6.275 6.146 1.00 22.17 A C ATOM 5242 CB MET A 344 41.151 5.989 6.556 1.00 21.39 A C ATOM 5245 CG MET A 344 41.055 5.081 7.781 1.00 19.99 A C ATOM 5248 SD MET A 344 39.358 4.723 8.256 1.00 25.10 A S ATOM 5249 CE MET A 344 39.531 3.255 9.301 1.00 20.13 A C ATOM 5253 C MET A 344 42.676 6.742 4.696 1.00 22.77 A C ATOM 5254 O MET A 344 42.854 5.928 3.799 1.00 23.66 A O ATOM 5256 N LYS A 345 42.553 8.045 4.454 1.00 24.61 A N ATOM 5257 CA LYS A 345 42.676 8.561 3.080 1.00 23.37 A C ATOM 5259 CB LYS A 345 42.640 10.084 3.016 1.00 26.29 A C ATOM 5262 CG LYS A 345 41.362 10.721 3.574 1.00 35.34 A C ATOM 5265 CD LYS A 345 41.422 12.243 3.653 1.00 37.03 A C ATOM 5268 CE LYS A 345 41.242 12.907 2.298 1.00 40.90 A C ATOM 5271 NZ LYS A 345 40.766 14.317 2.466 1.00 40.33 A N ATOM 5275 C LYS A 345 43.996 8.084 2.536 1.00 20.93 A C ATOM 5276 O LYS A 345 44.055 7.542 1.448 1.00 20.13 A O ATOM 5278 N LEU A 346 45.051 8.262 3.317 1.00 19.43 A N ATOM 5279 CA LEU A 346 46.392 7.947 2.861 1.00 19.97 A C ATOM 5281 CB LEU A 346 47.424 8.456 3.868 1.00 20.42 A C ATOM 5284 CG LEU A 346 48.885 8.424 3.430 1.00 24.60 A C ATOM 5286 CD1 LEU A 346 49.118 9.356 2.220 1.00 17.76 A C ATOM 5290 CD2 LEU A 346 49.789 8.796 4.594 1.00 27.43 A C ATOM 5294 C LEU A 346 46.534 6.470 2.661 1.00 21.21 A C ATOM 5295 O LEU A 346 47.029 6.024 1.655 1.00 21.29 A O ATOM 5297 N CYS A 347 46.051 5.698 3.624 1.00 23.15 A N ATOM 5298 CA CYS A 347 46.178 4.259 3.575 1.00 23.21 A C ATOM 5300 CB CYS A 347 45.760 3.653 4.943 1.00 25.14 A C ATOM 5303 SG CYS A 347 45.888 1.868 4.961 1.00 38.60 A S ATOM 5305 C CYS A 347 45.353 3.712 2.408 1.00 20.58 A C ATOM 5306 O CYS A 347 45.825 2.883 1.599 1.00 19.70 A O ATOM 5308 N PHE A 348 44.134 4.214 2.287 1.00 19.65 A N ATOM 5309 CA PHE A 348 43.299 3.863 1.155 1.00 19.61 A C ATOM 5311 CB PHE A 348 41.965 4.567 1.206 1.00 19.08 A C ATOM 5314 CG PHE A 348 41.070 4.192 0.080 1.00 18.31 A C ATOM 5315 CD1 PHE A 348 40.420 2.990 0.083 1.00 22.66 A C ATOM 5317 CE1 PHE A 348 39.594 2.623 −0.973 1.00 23.56 A C ATOM 5319 CZ PHE A 348 39.444 3.455 −2.043 1.00 21.10 A C ATOM 5321 CE2 PHE A 348 40.096 4.662 −2.069 1.00 20.44 A C ATOM 5323 CD2 PHE A 348 40.907 5.031 −1.011 1.00 24.44 A C ATOM 5325 C PHE A 348 43.951 4.141 −0.197 1.00 19.37 A C ATOM 5326 O PHE A 348 44.056 3.244 −1.037 1.00 17.63 A O ATOM 5328 N LEU A 349 44.408 5.367 −0.413 1.00 16.49 A N ATOM 5329 CA LEU A 349 44.896 5.727 −1.740 1.00 17.38 A C ATOM 5331 CB LEU A 349 45.157 7.229 −1.849 1.00 18.66 A C ATOM 5334 CG LEU A 349 45.633 7.793 −3.200 1.00 18.16 A C ATOM 5336 CD1 LEU A 349 44.756 7.364 −4.359 1.00 16.21 A C ATOM 5340 CD2 LEU A 349 45.700 9.321 −3.091 1.00 13.49 A C ATOM 5344 C LEU A 349 46.147 4.936 −2.076 1.00 18.98 A C ATOM 5345 O LEU A 349 46.338 4.550 −3.229 1.00 18.83 A O ATOM 5347 N ALA A 350 46.988 4.663 −1.078 1.00 19.12 A N ATOM 5348 CA ALA A 350 48.147 3.791 −1.316 1.00 20.75 A C ATOM 5350 CB ALA A 350 49.056 3.651 −0.061 1.00 19.54 A C ATOM 5354 C ALA A 350 47.716 2.426 −1.805 1.00 18.92 A C ATOM 5355 O ALA A 350 48.254 1.953 −2.787 1.00 24.29 A O ATOM 5357 N LEU A 351 46.776 1.795 −1.118 1.00 19.04 A N ATOM 5358 CA LEU A 351 46.259 0.458 −1.506 1.00 19.56 A C ATOM 5360 CB LEU A 351 45.172 −0.018 −0.503 1.00 20.96 A C ATOM 5363 CG LEU A 351 44.558 −1.412 −0.691 1.00 24.54 A C ATOM 5365 CD1 LEU A 351 45.630 −2.485 −0.530 1.00 21.96 A C ATOM 5369 CD2 LEU A 351 43.419 −1.645 0.287 1.00 20.98 A C ATOM 5373 C LEU A 351 45.637 0.519 −2.884 1.00 19.78 A C ATOM 5374 O LEU A 351 45.941 −0.293 −3.762 1.00 20.30 A O ATOM 5376 N TYR A 352 44.744 1.496 −3.056 1.00 19.85 A N ATOM 5377 CA TYR A 352 44.057 1.755 −4.316 1.00 17.66 A C ATOM 5379 CB TYR A 352 43.296 3.075 −4.210 1.00 20.69 A C ATOM 5382 CG TYR A 352 42.369 3.409 −5.357 1.00 16.64 A C ATOM 5383 CD1 TYR A 352 41.126 2.831 −5.453 1.00 21.99 A C ATOM 5385 CE1 TYR A 352 40.246 3.146 −6.517 1.00 23.38 A C ATOM 5387 CZ TYR A 352 40.618 4.062 −7.458 1.00 18.80 A C ATOM 5388 OH TYR A 352 39.759 4.352 −8.509 1.00 23.84 A O ATOM 5390 CE2 TYR A 352 41.867 4.678 −7.364 1.00 18.76 A C ATOM 5392 CD2 TYR A 352 42.727 4.353 −6.316 1.00 18.81 A C ATOM 5394 C TYR A 352 45.036 1.781 −5.468 1.00 17.34 A C ATOM 5395 O TYR A 352 44.892 1.025 −6.435 1.00 17.23 A O ATOM 5397 N ASN A 353 46.046 2.633 −5.374 1.00 17.53 A N ATOM 5398 CA ASN A 353 47.037 2.724 −6.448 1.00 18.17 A C ATOM 5400 CB ASN A 353 48.000 3.874 −6.213 1.00 18.33 A C ATOM 5403 CG ASN A 353 47.348 5.216 −6.429 1.00 21.12 A C ATOM 5404 OD1 ASN A 353 46.297 5.299 −7.068 1.00 16.85 A O ATOM 5405 ND2 ASN A 353 47.972 6.277 −5.919 1.00 12.84 A N ATOM 5408 C ASN A 353 47.819 1.441 −6.640 1.00 20.04 A C ATOM 5409 O ASN A 353 48.074 1.037 −7.770 1.00 19.38 A O ATOM 5411 N THR A 354 48.201 0.790 −5.542 1.00 19.93 A N ATOM 5412 CA THR A 354 48.989 −0.408 −5.668 1.00 19.28 A C ATOM 5414 CB THR A 354 49.441 −0.944 −4.307 1.00 21.85 A C ATOM 5416 OG1 THR A 354 50.234 0.055 −3.636 1.00 18.52 A O ATOM 5418 CG2 THR A 354 50.267 −2.217 −4.509 1.00 20.83 A C ATOM 5422 C THR A 354 48.210 −1.475 −6.410 1.00 19.60 A C ATOM 5423 O THR A 354 48.749 −2.127 −7.287 1.00 21.37 A O ATOM 5425 N ILE A 355 46.939 −1.651 −6.065 1.00 19.20 A N ATOM 5426 CA ILE A 355 46.126 −2.677 −6.694 1.00 18.48 A C ATOM 5428 CB ILE A 355 44.795 −2.901 −5.921 1.00 18.37 A C ATOM 5430 CG1 ILE A 355 45.061 −3.350 −4.483 1.00 20.38 A C ATOM 5433 CD1 ILE A 355 46.192 −4.335 −4.324 1.00 29.16 A C ATOM 5437 CG2 ILE A 355 43.883 −3.902 −6.618 1.00 18.31 A C ATOM 5441 C ILE A 355 45.879 −2.313 −8.176 1.00 19.56 A C ATOM 5442 O ILE A 355 45.989 −3.176 −9.061 1.00 18.02 A O ATOM 5444 N ASN A 356 45.581 −1.042 −8.450 1.00 18.36 A N ATOM 5445 CA ASN A 356 45.340 −0.616 −9.819 1.00 18.34 A C ATOM 5447 CB ASN A 356 44.863 0.832 −9.900 1.00 17.65 A C ATOM 5450 CG ASN A 356 43.476 1.028 −9.334 1.00 16.23 A C ATOM 5451 OD1 ASN A 356 42.725 0.075 −9.138 1.00 19.91 A O ATOM 5452 ND2 ASN A 356 43.116 2.290 −9.083 1.00 20.98 A N ATOM 5455 C ASN A 356 46.564 −0.825 −10.703 1.00 19.43 A C ATOM 5456 O ASN A 356 46.422 −1.142 −11.887 1.00 20.70 A O ATOM 5458 N GLU A 357 47.753 −0.671 −10.132 1.00 20.68 A N ATOM 5459 CA AGLU A 357 48.994 −0.866 −10.888 0.50 21.52 A C ATOM 5460 CA BGLU A 357 49.010 −0.884 −10.874 0.50 20.35 A C ATOM 5463 CB AGLU A 357 50.194 −0.231 −10.148 0.50 22.00 A C ATOM 5464 CB BGLU A 357 50.217 −0.366 −10.079 0.50 20.11 A C ATOM 5469 CG AGLU A 357 50.380 1.275 −10.466 0.50 28.65 A C ATOM 5470 CG BGLU A 357 51.579 −0.813 −10.618 0.50 19.78 A C ATOM 5475 CD AGLU A 357 50.846 2.136 −9.291 0.50 33.37 A C ATOM 5476 CD BGLU A 357 52.743 −0.147 −9.918 0.50 23.84 A C ATOM 5477 OE1 AGLU A 357 51.301 1.583 −8.270 0.50 33.65 A O ATOM 5478 OE1 BGLU A 357 52.594 0.268 −8.744 0.50 29.12 A O ATOM 5479 OE2 AGLU A 357 50.754 3.387 −9.402 0.50 37.95 A O ATOM 5480 OE2 BGLU A 357 53.816 −0.051 −10.544 0.50 25.37 A O ATOM 5481 C GLU A 357 49.201 −2.360 −11.206 1.00 19.73 A C ATOM 5482 O GLU A 357 49.669 −2.716 −12.285 1.00 18.33 A O ATOM 5484 N ILE A 358 48.822 −3.231 −10.280 1.00 20.56 A N ATOM 5485 CA ILE A 358 48.876 −4.659 −10.536 1.00 20.75 A C ATOM 5487 CB ILE A 358 48.706 −5.508 −9.260 1.00 22.24 A C ATOM 5489 CG1 ILE A 358 49.953 −5.357 −8.385 1.00 23.28 A C ATOM 5492 CD1 ILE A 358 49.763 −5.808 −6.885 1.00 20.16 A C ATOM 5496 CG2 ILE A 358 48.505 −7.015 −9.623 1.00 19.35 A C ATOM 5500 C ILE A 358 47.841 −5.018 −11.601 1.00 21.23 A C ATOM 5501 O ILE A 358 48.119 −5.810 −12.489 1.00 22.96 A O ATOM 5503 N ALA A 359 46.665 −4.418 −11.544 1.00 21.80 A N ATOM 5504 CA ALA A 359 45.693 −4.608 −12.625 1.00 20.99 A C ATOM 5506 CB ALA A 359 44.394 −3.864 −12.316 1.00 19.18 A C ATOM 5510 C ALA A 359 46.272 −4.131 −13.952 1.00 20.71 A C ATOM 5511 O ALA A 359 46.094 −4.789 −14.991 1.00 19.81 A O ATOM 5513 N TYR A 360 46.943 −2.972 −13.948 1.00 20.31 A N ATOM 5514 CA TYR A 360 47.532 −2.470 −15.209 1.00 18.47 A C ATOM 5516 CB TYR A 360 48.199 −1.099 −15.038 1.00 18.10 A C ATOM 5519 CG TYR A 360 48.851 −0.625 −16.318 1.00 15.44 A C ATOM 5520 CD1 TYR A 360 48.097 −0.026 −17.321 1.00 12.29 A C ATOM 5522 CE1 TYR A 360 48.666 0.360 −18.518 1.00 9.88 A C ATOM 5524 CZ TYR A 360 50.010 0.118 −18.751 1.00 13.42 A C ATOM 5525 OH TYR A 360 50.565 0.520 −19.932 1.00 16.96 A O ATOM 5527 CE2 TYR A 360 50.790 −0.485 −17.786 1.00 8.89 A C ATOM 5529 CD2 TYR A 360 50.203 −0.861 −16.568 1.00 13.09 A C ATOM 5531 C TYR A 360 48.519 −3.512 −15.761 1.00 19.61 A C ATOM 5532 O TYR A 360 48.396 −3.939 −16.901 1.00 21.66 A O ATOM 5534 N ASP A 361 49.453 −3.976 −14.931 1.00 20.81 A N ATOM 5535 CA ASP A 361 50.465 −4.969 −15.377 1.00 22.44 A C ATOM 5537 CB ASP A 361 51.307 −5.501 −14.218 1.00 23.16 A C ATOM 5540 CG ASP A 361 52.175 −4.431 −13.551 1.00 29.65 A C ATOM 5541 OD1 ASP A 361 52.375 −3.309 −14.095 1.00 30.92 A O ATOM 5542 OD2 ASP A 361 52.684 −4.754 −12.462 1.00 39.54 A O ATOM 5543 C ASP A 361 49.828 −6.163 −16.063 1.00 21.86 A C ATOM 5544 O ASP A 361 50.296 −6.612 −17.095 1.00 20.13 A O ATOM 5546 N ASN A 362 48.751 −6.668 −15.482 1.00 22.54 A N ATOM 5547 CA ASN A 362 48.066 −7.813 −16.036 1.00 23.29 A C ATOM 5549 CB ASN A 362 47.121 −8.407 −15.005 1.00 26.74 A C ATOM 5552 CG ASN A 362 47.831 −9.340 −14.072 1.00 27.43 A C ATOM 5553 OD1 ASN A 362 47.917 −10.526 −14.337 1.00 26.92 A O ATOM 5554 ND2 ASN A 362 48.403 −8.797 −13.004 1.00 30.27 A N ATOM 5557 C ASN A 362 47.324 −7.491 −17.322 1.00 24.48 A C ATOM 5558 O ASN A 362 47.420 −8.243 −18.278 1.00 23.43 A O ATOM 5560 N LEU A 363 46.628 −6.354 −17.362 1.00 23.94 A N ATOM 5561 CA LEU A 363 45.966 −5.918 −18.581 1.00 22.60 A C ATOM 5563 CB LEU A 363 45.287 −4.570 −18.389 1.00 20.18 A C ATOM 5566 CG LEU A 363 44.590 −3.967 −19.601 1.00 23.96 A C ATOM 5568 CD1 LEU A 363 43.503 −4.907 −20.108 1.00 14.88 A C ATOM 5572 CD2 LEU A 363 44.030 −2.552 −19.279 1.00 17.49 A C ATOM 5576 C LEU A 363 46.985 −5.838 −19.707 1.00 23.16 A C ATOM 5577 O LEU A 363 46.734 −6.307 −20.800 1.00 24.96 A O ATOM 5579 N LYS A 364 48.143 −5.263 −19.432 1.00 24.48 A N ATOM 5580 CA LYS A 364 49.149 −5.054 −20.469 1.00 23.95 A C ATOM 5582 CB LYS A 364 50.288 −4.165 −19.964 1.00 23.52 A C ATOM 5585 CG LYS A 364 51.326 −3.846 −21.033 1.00 28.36 A C ATOM 5588 CD LYS A 364 52.416 −2.904 −20.568 1.00 33.18 A C ATOM 5591 CE LYS A 364 53.575 −3.616 −19.903 1.00 29.42 A C ATOM 5594 NZ LYS A 364 53.277 −3.791 −18.504 1.00 34.02 A N ATOM 5598 C LYS A 364 49.752 −6.361 −20.967 1.00 25.61 A C ATOM 5599 O LYS A 364 50.000 −6.488 −22.163 1.00 24.47 A O ATOM 5601 N ASP A 365 50.020 −7.304 −20.053 1.00 26.63 A N ATOM 5602 CA ASP A 365 50.760 −8.530 −20.395 1.00 29.60 A C ATOM 5604 CB ASP A 365 51.663 −8.970 −19.235 1.00 28.67 A C ATOM 5607 CG ASP A 365 52.733 −7.936 −18.896 1.00 38.74 A C ATOM 5608 OD1 ASP A 365 52.986 −7.008 −19.711 1.00 45.92 A O ATOM 5609 OD2 ASP A 365 53.314 −8.040 −17.799 1.00 47.56 A O ATOM 5610 C ASP A 365 49.867 −9.705 −20.793 1.00 30.41 A C ATOM 5611 O ASP A 365 50.295 −10.549 −21.574 1.00 30.84 A O ATOM 5613 N LYS A 366 48.655 −9.775 −20.238 1.00 29.91 A N ATOM 5614 CA LYS A 366 47.732 −10.890 −20.515 1.00 31.66 A C ATOM 5616 CB LYS A 366 47.282 −11.573 −19.222 1.00 31.27 A C ATOM 5619 CG LYS A 366 48.393 −12.030 −18.325 1.00 37.24 A C ATOM 5622 CD LYS A 366 47.831 −12.620 −17.023 1.00 51.74 A C ATOM 5625 CE LYS A 366 48.938 −13.013 −16.050 1.00 58.01 A C ATOM 5628 NZ LYS A 366 49.938 −13.909 −16.721 1.00 65.78 A N ATOM 5632 C LYS A 366 46.493 −10.433 −21.260 1.00 31.36 A C ATOM 5633 O LYS A 366 45.638 −11.244 −21.579 1.00 34.55 A O ATOM 5635 N GLY A 367 46.372 −9.139 −21.516 1.00 29.56 A N ATOM 5636 CA GLY A 367 45.215 −8.637 −22.233 1.00 28.57 A C ATOM 5639 C GLY A 367 43.893 −8.799 −21.503 1.00 28.83 A C ATOM 5640 O GLY A 367 42.846 −8.755 −22.145 1.00 29.71 A O ATOM 5642 N GLU A 368 43.921 −8.940 −20.174 1.00 27.22 A N ATOM 5643 CA GLU A 368 42.685 −9.147 −19.396 1.00 27.74 A C ATOM 5645 CB GLU A 368 42.648 −10.563 −18.784 1.00 28.93 A C ATOM 5648 CG GLU A 368 42.646 −11.732 −19.784 1.00 38.81 A C ATOM 5651 CD GLU A 368 41.343 −11.888 −20.567 1.00 47.54 A C ATOM 5652 OE1 GLU A 368 40.389 −11.104 −20.360 1.00 49.64 A O ATOM 5653 OE2 GLU A 368 41.284 −12.808 −21.410 1.00 54.32 A O ATOM 5654 C GLU A 368 42.543 −8.135 −18.268 1.00 24.49 A C ATOM 5655 O GLU A 368 43.499 −7.861 −17.565 1.00 25.04 A O ATOM 5657 N ASN A 369 41.345 −7.610 −18.068 1.00 23.64 A N ATOM 5658 CA ASN A 369 41.070 −6.743 −16.922 1.00 23.23 A C ATOM 5660 CB ASN A 369 39.965 −5.744 −17.246 1.00 23.47 A C ATOM 5663 CG ASN A 369 39.625 −4.846 −16.059 1.00 26.64 A C ATOM 5664 OD1 ASN A 369 40.103 −5.046 −14.935 1.00 27.47 A O ATOM 5665 ND2 ASN A 369 38.801 −3.848 −16.310 1.00 21.10 A N ATOM 5668 C ASN A 369 40.646 −7.564 −15.716 1.00 22.50 A C ATOM 5669 O ASN A 369 39.515 −8.037 −15.662 1.00 23.28 A O ATOM 5671 N ILE A 370 41.548 −7.697 −14.749 1.00 20.03 A N ATOM 5672 CA ILE A 370 41.339 −8.531 −13.587 1.00 20.96 A C ATOM 5674 CB ILE A 370 42.596 −9.422 −13.301 1.00 22.00 A C ATOM 5676 CG1 ILE A 370 43.822 −8.555 −12.918 1.00 22.25 A C ATOM 5679 CD1 ILE A 370 44.991 −9.307 −12.305 1.00 24.22 A C ATOM 5683 CG2 ILE A 370 42.925 −10.275 −14.521 1.00 22.49 A C ATOM 5687 C ILE A 370 41.038 −7.700 −12.345 1.00 22.36 A C ATOM 5688 O ILE A 370 40.934 −8.245 −11.246 1.00 23.94 A O ATOM 5690 N LEU A 371 40.927 −6.388 −12.500 1.00 21.80 A N ATOM 5691 CA LEU A 371 40.640 −5.508 −11.350 1.00 22.30 A C ATOM 5693 CB LEU A 371 40.420 −4.071 −11.808 1.00 20.64 A C ATOM 5696 CG LEU A 371 40.364 −3.036 −10.684 1.00 22.73 A C ATOM 5698 CD1 LEU A 371 41.588 −3.133 −9.844 1.00 17.10 A C ATOM 5702 CD2 LEU A 371 40.230 −1.641 −11.247 1.00 17.41 A C ATOM 5706 C LEU A 371 39.477 −5.941 −10.442 1.00 22.81 A C ATOM 5707 O LEU A 371 39.636 −5.947 −9.221 1.00 25.48 A O ATOM 5709 N PRO A 372 38.323 −6.322 −11.018 1.00 24.23 A N ATOM 5710 CA PRO A 372 37.194 −6.750 −10.172 1.00 24.59 A C ATOM 5712 CB PRO A 372 36.136 −7.207 −11.186 1.00 25.42 A C ATOM 5715 CG PRO A 372 36.502 −6.557 −12.470 1.00 27.16 A C ATOM 5718 CD PRO A 372 37.991 −6.388 −12.457 1.00 26.65 A C ATOM 5721 C PRO A 372 37.520 −7.921 −9.235 1.00 24.27 A C ATOM 5722 O PRO A 372 36.936 −8.036 −8.165 1.00 24.63 A O ATOM 5723 N TYR A 373 38.444 −8.778 −9.629 1.00 22.56 A N ATOM 5724 CA TYR A 373 38.785 −9.923 −8.804 1.00 23.41 A C ATOM 5726 CB TYR A 373 39.355 −11.030 −9.678 1.00 25.44 A C ATOM 5729 CG TYR A 373 38.520 −11.288 −10.950 1.00 28.81 A C ATOM 5730 CD1 TYR A 373 37.220 −11.783 −10.877 1.00 39.04 A C ATOM 5732 CE1 TYR A 373 36.452 −12.013 −12.040 1.00 38.13 A C ATOM 5734 CZ TYR A 373 36.999 −11.743 −13.272 1.00 39.16 A C ATOM 5735 OH TYR A 373 36.279 −11.950 −14.425 1.00 47.13 A O ATOM 5737 CE2 TYR A 373 38.284 −11.243 −13.361 1.00 40.64 A C ATOM 5739 CD2 TYR A 373 39.037 −11.025 −12.208 1.00 30.70 A C ATOM 5741 C TYR A 373 39.750 −9.516 −7.676 1.00 24.07 A C ATOM 5742 O TYR A 373 39.657 −10.021 −6.574 1.00 24.75 A O ATOM 5744 N LEU A 374 40.640 −8.562 −7.935 1.00 21.92 A N ATOM 5745 CA LEU A 374 41.543 −8.065 −6.904 1.00 20.05 A C ATOM 5747 CB LEU A 374 42.697 −7.268 −7.533 1.00 18.59 A C ATOM 5750 CG LEU A 374 43.440 −7.920 −8.708 1.00 21.18 A C ATOM 5752 CD1 LEU A 374 44.568 −7.012 −9.281 1.00 15.63 A C ATOM 5756 CD2 LEU A 374 44.002 −9.288 −8.329 1.00 21.62 A C ATOM 5760 C LEU A 374 40.748 −7.194 −5.916 1.00 19.90 A C ATOM 5761 O LEU A 374 40.908 −7.312 −4.711 1.00 21.65 A O ATOM 5763 N THR A 375 39.875 −6.324 −6.403 1.00 19.48 A N ATOM 5764 CA THR A 375 39.118 −5.465 −5.482 1.00 20.29 A C ATOM 5766 CB THR A 375 38.419 −4.297 −6.219 1.00 21.53 A C ATOM 5768 OG1 THR A 375 37.533 −4.818 −7.222 1.00 23.71 A O ATOM 5770 CG2 THR A 375 39.458 −3.379 −6.875 1.00 17.49 A C ATOM 5774 C THR A 375 38.093 −6.269 −4.665 1.00 20.82 A C ATOM 5775 O THR A 375 37.854 −5.989 −3.499 1.00 23.34 A O ATOM 5777 N LYS A 376 37.510 −7.299 −5.243 1.00 21.46 A N ATOM 5778 CA LYS A 376 36.592 −8.149 −4.476 1.00 22.11 A C ATOM 5780 CB LYS A 376 35.915 −9.162 −5.411 1.00 24.77 A C ATOM 5783 CG LYS A 376 35.075 −10.225 −4.732 1.00 30.99 A C ATOM 5786 CD LYS A 376 33.828 −9.640 −4.119 1.00 37.68 A C ATOM 5789 CE LYS A 376 32.933 −10.753 −3.552 1.00 43.15 A C ATOM 5792 NZ LYS A 376 32.101 −10.264 −2.422 1.00 47.30 A N ATOM 5796 C LYS A 376 37.324 −8.858 −3.345 1.00 20.58 A C ATOM 5797 O LYS A 376 36.805 −8.964 −2.259 1.00 22.25 A O ATOM 5799 N ALA A 377 38.522 −9.369 −3.612 1.00 20.81 A N ATOM 5800 CA ALA A 377 39.307 −10.072 −2.597 1.00 19.65 A C ATOM 5802 CB ALA A 377 40.581 −10.615 −3.187 1.00 20.54 A C ATOM 5806 C ALA A 377 39.635 −9.157 −1.438 1.00 22.21 A C ATOM 5807 O ALA A 377 39.599 −9.577 −0.265 1.00 24.06 A O ATOM 5809 N TRP A 378 39.918 −7.892 −1.748 1.00 20.95 A N ATOM 5810 CA TRP A 378 40.154 −6.899 −0.686 1.00 19.91 A C ATOM 5812 CB TRP A 378 40.823 −5.645 −1.240 1.00 19.12 A C ATOM 5815 CG TRP A 378 42.266 −5.807 −1.234 1.00 18.82 A C ATOM 5816 CD1 TRP A 378 43.045 −6.192 −2.261 1.00 17.16 A C ATOM 5818 NE1 TRP A 378 44.343 −6.281 −1.858 1.00 20.04 A N ATOM 5820 CE2 TRP A 378 44.416 −5.964 −0.528 1.00 15.91 A C ATOM 5821 CD2 TRP A 378 43.115 −5.692 −0.098 1.00 19.67 A C ATOM 5822 CE3 TRP A 378 42.903 −5.345 1.237 1.00 17.94 A C ATOM 5824 CZ3 TRP A 378 43.989 −5.290 2.080 1.00 22.51 A C ATOM 5826 CH2 TRP A 378 45.271 −5.571 1.624 1.00 15.95 A C ATOM 5828 CZ2 TRP A 378 45.510 −5.902 0.324 1.00 15.79 A C ATOM 5830 C TRP A 378 38.908 −6.516 0.109 1.00 19.57 A C ATOM 5831 O TRP A 378 38.994 −6.297 1.313 1.00 19.10 A O ATOM 5833 N ALA A 379 37.779 −6.386 −0.577 1.00 17.51 A N ATOM 5834 CA ALA A 379 36.511 −6.130 0.083 1.00 18.56 A C ATOM 5836 CB ALA A 379 35.377 −5.971 −0.957 1.00 19.21 A C ATOM 5840 C ALA A 379 36.179 −7.267 1.040 1.00 20.27 A C ATOM 5841 O ALA A 379 35.706 −7.046 2.155 1.00 22.16 A O ATOM 5843 N ASP A 380 36.405 −8.495 0.601 1.00 20.50 A N ATOM 5844 CA ASP A 380 36.081 −9.638 1.448 1.00 21.17 A C ATOM 5846 CB ASP A 380 36.238 −10.964 0.695 1.00 21.00 A C ATOM 5849 CG ASP A 380 35.187 −11.187 −0.412 1.00 21.43 A C ATOM 5850 OD1 ASP A 380 34.167 −10.468 −0.515 1.00 25.52 A O ATOM 5851 OD2 ASP A 380 35.379 −12.153 −1.177 1.00 29.89 A O ATOM 5852 C ASP A 380 37.009 −9.625 2.662 1.00 21.11 A C ATOM 5853 O ASP A 380 36.589 −9.925 3.778 1.00 25.31 A O ATOM 5855 N LEU A 381 38.273 −9.283 2.456 1.00 21.14 A N ATOM 5856 CA LEU A 381 39.216 −9.230 3.581 1.00 20.85 A C ATOM 5858 CB LEU A 381 40.641 −8.952 3.113 1.00 19.68 A C ATOM 5861 CG LEU A 381 41.690 −8.904 4.212 1.00 22.69 A C ATOM 5863 CD1 LEU A 381 41.645 −10.153 5.076 1.00 17.32 A C ATOM 5867 CD2 LEU A 381 43.038 −8.730 3.552 1.00 20.69 A C ATOM 5871 C LEU A 381 38.781 −8.183 4.584 1.00 18.62 A C ATOM 5872 O LEU A 381 38.690 −8.459 5.778 1.00 20.47 A O ATOM 5874 N CYS A 382 38.457 −6.990 4.102 1.00 21.03 A N ATOM 5875 CA CYS A 382 38.090 −5.891 5.023 1.00 20.56 A C ATOM 5877 CB CYS A 382 38.032 −4.551 4.283 1.00 21.31 A C ATOM 5880 SG CYS A 382 39.664 −3.962 3.712 1.00 24.85 A S ATOM 5882 C CYS A 382 36.799 −6.217 5.764 1.00 19.73 A C ATOM 5883 O CYS A 382 36.676 −5.968 6.959 1.00 23.50 A O ATOM 5885 N ASN A 383 35.850 −6.829 5.080 1.00 21.14 A N ATOM 5886 CA ASN A 383 34.646 −7.367 5.742 1.00 21.35 A C ATOM 5888 CB ASN A 383 33.630 −7.901 4.721 1.00 21.45 A C ATOM 5891 CG ASN A 383 32.701 −6.810 4.213 1.00 26.00 A C ATOM 5892 OD1 ASN A 383 31.849 −6.300 4.960 1.00 32.37 A O ATOM 5893 ND2 ASN A 383 32.875 −6.426 2.948 1.00 24.66 A N ATOM 5896 C ASN A 383 34.936 −8.458 6.753 1.00 21.61 A C ATOM 5897 O ASN A 383 34.282 −8.523 7.780 1.00 22.90 A O ATOM 5899 N ALA A 384 35.900 −9.328 6.486 1.00 21.49 A N ATOM 5900 CA ALA A 384 36.234 −10.330 7.505 1.00 19.41 A C ATOM 5902 CB ALA A 384 37.163 −11.414 6.934 1.00 15.55 A C ATOM 5906 C ALA A 384 36.851 −9.602 8.744 1.00 18.65 A C ATOM 5907 O ALA A 384 36.449 −9.851 9.886 1.00 18.75 A O ATOM 5909 N PHE A 385 37.785 −8.682 8.517 1.00 18.91 A N ATOM 5910 CA PHE A 385 38.319 −7.831 9.626 1.00 20.64 A C ATOM 5912 CB PHE A 385 39.311 −6.773 9.127 1.00 21.86 A C ATOM 5915 CG PHE A 385 40.647 −7.296 8.653 1.00 18.71 A C ATOM 5916 CD1 PHE A 385 41.305 −8.317 9.312 1.00 27.92 A C ATOM 5918 CE1 PHE A 385 42.566 −8.754 8.889 1.00 23.74 A C ATOM 5920 CZ PHE A 385 43.190 −8.126 7.810 1.00 25.70 A C ATOM 5922 CE2 PHE A 385 42.544 −7.058 7.171 1.00 24.54 A C ATOM 5924 CD2 PHE A 385 41.296 −6.652 7.608 1.00 22.39 A C ATOM 5926 C PHE A 385 37.199 −7.059 10.362 1.00 21.40 A C ATOM 5927 O PHE A 385 37.158 −7.013 11.590 1.00 24.82 A O ATOM 5929 N LEU A 386 36.293 −6.439 9.621 1.00 21.38 A N ATOM 5930 CA LEU A 386 35.174 −5.721 10.254 1.00 20.88 A C ATOM 5932 CB LEU A 386 34.226 −5.138 9.186 1.00 20.67 A C ATOM 5935 CG LEU A 386 33.068 −4.256 9.667 1.00 24.05 A C ATOM 5937 CD1 LEU A 386 33.624 −2.975 10.307 1.00 17.84 A C ATOM 5941 CD2 LEU A 386 32.096 −3.922 8.539 1.00 14.02 A C ATOM 5945 C LEU A 386 34.390 −6.629 11.200 1.00 20.84 A C ATOM 5946 O LEU A 386 34.093 −6.263 12.350 1.00 22.03 A O ATOM 5948 N GLN A 387 34.050 −7.816 10.725 1.00 21.21 A N ATOM 5949 CA GLN A 387 33.315 −8.754 11.561 1.00 22.62 A C ATOM 5951 CB GLN A 387 33.016 −10.052 10.816 1.00 23.54 A C ATOM 5954 CG GLN A 387 32.222 −11.067 11.634 1.00 23.83 A C ATOM 5957 CD GLN A 387 30.830 −10.587 11.951 1.00 23.98 A C ATOM 5958 OE1 GLN A 387 30.560 −10.108 13.050 1.00 26.91 A O ATOM 5959 NE2 GLN A 387 29.933 −10.715 10.987 1.00 30.18 A N ATOM 5962 C GLN A 387 34.082 −9.045 12.847 1.00 23.68 A C ATOM 5963 O GLN A 387 33.491 −9.080 13.933 1.00 21.96 A O ATOM 5965 N GLU A 388 35.393 −9.237 12.738 1.00 24.58 A N ATOM 5966 CA GLU A 388 36.209 −9.469 13.935 1.00 24.13 A C ATOM 5968 CB GLU A 388 37.684 −9.705 13.601 1.00 23.71 A C ATOM 5971 CG GLU A 388 37.932 −11.099 13.059 1.00 31.30 A C ATOM 5974 CD GLU A 388 39.385 −11.373 12.675 1.00 36.02 A C ATOM 5975 OE1 GLU A 388 40.209 −10.407 12.511 1.00 32.55 A O ATOM 5976 OE2 GLU A 388 39.674 −12.582 12.531 1.00 30.48 A O ATOM 5977 C GLU A 388 36.108 −8.308 14.885 1.00 21.29 A C ATOM 5978 O GLU A 388 35.996 −8.503 16.091 1.00 19.35 A O ATOM 5980 N ALA A 389 36.164 −7.098 14.343 1.00 20.43 A N ATOM 5981 CA ALA A 389 36.155 −5.918 15.196 1.00 19.95 A C ATOM 5983 CB ALA A 389 36.443 −4.670 14.404 1.00 17.61 A C ATOM 5987 C ALA A 389 34.797 −5.816 15.883 1.00 20.79 A C ATOM 5988 O ALA A 389 34.724 −5.453 17.045 1.00 22.39 A O ATOM 5990 N LYS A 390 33.729 −6.150 15.162 1.00 21.47 A N ATOM 5991 CA LYS A 390 32.387 −6.056 15.711 1.00 22.95 A C ATOM 5993 CB LYS A 390 31.347 −6.272 14.611 1.00 22.84 A C ATOM 5996 CG LYS A 390 31.150 −5.048 13.739 1.00 25.85 A C ATOM 5999 CD LYS A 390 30.033 −5.259 12.719 1.00 33.32 A C ATOM 6002 CE LYS A 390 29.796 −4.002 11.896 1.00 31.02 A C ATOM 6005 NZ LYS A 390 28.888 −4.249 10.737 1.00 29.50 A N ATOM 6009 C LYS A 390 32.187 −7.065 16.837 1.00 24.05 A C ATOM 6010 O LYS A 390 31.632 −6.753 17.885 1.00 24.65 A O ATOM 6012 N TRP A 391 32.641 −8.283 16.616 1.00 24.13 A N ATOM 6013 CA TRP A 391 32.563 −9.303 17.650 1.00 24.58 A C ATOM 6015 CB TRP A 391 33.143 −10.619 17.154 1.00 23.28 A C ATOM 6018 CG TRP A 391 32.225 −11.389 16.264 1.00 23.35 A C ATOM 6019 CD1 TRP A 391 30.864 −11.354 16.250 1.00 21.14 A C ATOM 6021 NE1 TRP A 391 30.373 −12.235 15.311 1.00 24.01 A N ATOM 6023 CE2 TRP A 391 31.428 −12.876 14.721 1.00 24.82 A C ATOM 6024 CD2 TRP A 391 32.610 −12.365 15.298 1.00 19.00 A C ATOM 6025 CE3 TRP A 391 33.838 −12.866 14.868 1.00 23.69 A C ATOM 6027 CZ3 TRP A 391 33.850 −13.832 13.882 1.00 17.43 A C ATOM 6029 CH2 TRP A 391 32.657 −14.317 13.325 1.00 20.76 A C ATOM 6031 CZ2 TRP A 391 31.444 −13.852 13.722 1.00 22.46 A C ATOM 6033 C TRP A 391 33.288 −8.885 18.920 1.00 25.69 A C ATOM 6034 O TRP A 391 32.775 −9.100 20.029 1.00 25.53 A O ATOM 6036 N LEU A 392 34.463 −8.286 18.764 1.00 25.73 A N ATOM 6037 CA LEU A 392 35.227 −7.805 19.918 1.00 28.86 A C ATOM 6039 CB LEU A 392 36.604 −7.319 19.470 1.00 30.60 A C ATOM 6042 CG LEU A 392 37.653 −7.119 20.559 1.00 36.67 A C ATOM 6044 CD1 LEU A 392 39.053 −7.245 19.946 1.00 40.63 A C ATOM 6048 CD2 LEU A 392 37.478 −5.762 21.262 1.00 44.84 A C ATOM 6052 C LEU A 392 34.491 −6.698 20.687 1.00 28.06 A C ATOM 6053 O LEU A 392 34.347 −6.775 21.910 1.00 28.35 A O ATOM 6055 N TYR A 393 34.014 −5.684 19.972 1.00 26.84 A N ATOM 6056 CA TYR A 393 33.328 −4.551 20.604 1.00 27.94 A C ATOM 6058 CB TYR A 393 32.933 −3.512 19.543 1.00 29.05 A C ATOM 6061 CG TYR A 393 32.189 −2.306 20.078 1.00 33.13 A C ATOM 6062 CD1 TYR A 393 32.877 −1.226 20.635 1.00 38.76 A C ATOM 6064 CE1 TYR A 393 32.198 −0.112 21.146 1.00 40.86 A C ATOM 6066 CZ TYR A 393 30.817 −0.066 21.085 1.00 42.91 A C ATOM 6067 OH TYR A 393 30.143 1.030 21.583 1.00 50.26 A O ATOM 6069 CE2 TYR A 393 30.107 −1.123 20.526 1.00 40.58 A C ATOM 6071 CD2 TYR A 393 30.801 −2.236 20.021 1.00 39.09 A C ATOM 6073 C TYR A 393 32.079 −4.996 21.374 1.00 27.58 A C ATOM 6074 O TYR A 393 31.853 −4.573 22.506 1.00 26.98 A O ATOM 6076 N ASN A 394 31.282 −5.851 20.738 1.00 27.69 A N ATOM 6077 CA ASN A 394 30.010 −6.312 21.272 1.00 27.80 A C ATOM 6079 CB ASN A 394 29.091 −6.716 20.120 1.00 26.84 A C ATOM 6082 CG ASN A 394 28.616 −5.521 19.324 1.00 28.06 A C ATOM 6083 OD1 ASN A 394 28.225 −4.498 19.890 1.00 31.10 A O ATOM 6084 ND2 ASN A 394 28.644 −5.636 18.010 1.00 32.05 A N ATOM 6087 C ASN A 394 30.156 −7.458 22.261 1.00 29.31 A C ATOM 6088 O ASN A 394 29.158 −7.944 22.801 1.00 29.60 A O ATOM 6090 N LYS A 395 31.402 −7.865 22.511 1.00 30.96 A N ATOM 6091 CA LYS A 395 31.706 −9.034 23.329 1.00 32.88 A C ATOM 6093 CB LYS A 395 31.443 −8.749 24.815 1.00 34.38 A C ATOM 6096 CG LYS A 395 32.374 −7.690 25.445 1.00 42.56 A C ATOM 6099 CD LYS A 395 31.603 −6.475 25.978 1.00 50.78 A C ATOM 6102 CE LYS A 395 32.434 −5.652 26.968 1.00 54.57 A C ATOM 6105 NZ LYS A 395 31.610 −4.582 27.621 1.00 55.82 A N ATOM 6109 C LYS A 395 30.923 −10.279 22.863 1.00 32.85 A C ATOM 6110 O LYS A 395 30.490 −11.090 23.686 1.00 34.23 A O ATOM 6112 N SER A 396 30.765 −10.431 21.546 1.00 31.79 A N ATOM 6113 CA SER A 396 30.034 −11.571 20.970 1.00 30.45 A C ATOM 6115 CB SER A 396 29.868 −11.402 19.464 1.00 29.95 A C ATOM 6118 OG SER A 396 29.007 −10.318 19.148 1.00 31.64 A O ATOM 6120 C SER A 396 30.730 −12.899 21.259 1.00 29.40 A C ATOM 6121 O SER A 396 31.933 −12.948 21.512 1.00 31.77 A O ATOM 6123 N THR A 397 29.948 −13.971 21.222 1.00 28.99 A N ATOM 6124 CA THR A 397 30.423 −15.315 21.529 1.00 27.69 A C ATOM 6126 CB THR A 397 29.822 −15.821 22.880 1.00 28.85 A C ATOM 6128 OG1 THR A 397 28.392 −15.908 22.774 1.00 29.53 A O ATOM 6130 CG2 THR A 397 30.183 −14.877 24.028 1.00 27.66 A C ATOM 6134 C THR A 397 30.017 −16.273 20.407 1.00 26.90 A C ATOM 6135 O THR A 397 29.316 −17.266 20.658 1.00 29.05 A O ATOM 6137 N PRO A 398 30.466 −16.003 19.168 1.00 23.74 A N ATOM 6138 CA PRO A 398 30.051 −16.849 18.046 1.00 23.94 A C ATOM 6140 CB PRO A 398 30.741 −16.196 16.855 1.00 23.33 A C ATOM 6143 CG PRO A 398 32.020 −15.684 17.456 1.00 24.23 A C ATOM 6146 CD PRO A 398 31.632 −15.176 18.816 1.00 23.86 A C ATOM 6149 C PRO A 398 30.558 −18.274 18.192 1.00 22.60 A C ATOM 6150 O PRO A 398 31.522 −18.516 18.905 1.00 23.64 A O ATOM 6151 N THR A 399 29.918 −19.210 17.511 1.00 22.40 A N ATOM 6152 CA THR A 399 30.354 −20.602 17.542 1.00 21.81 A C ATOM 6154 CB THR A 399 29.367 −21.499 16.770 1.00 23.98 A C ATOM 6156 OG1 THR A 399 29.377 −21.129 15.376 1.00 24.75 A O ATOM 6158 CG2 THR A 399 27.909 −21.381 17.366 1.00 14.91 A C ATOM 6162 C THR A 399 31.716 −20.718 16.882 1.00 22.61 A C ATOM 6163 O THR A 399 32.127 −19.807 16.181 1.00 26.36 A O ATOM 6165 N PHE A 400 32.411 −21.839 17.094 1.00 23.40 A N ATOM 6166 CA PHE A 400 33.704 −22.095 16.443 1.00 22.11 A C ATOM 6168 CB PHE A 400 34.252 −23.474 16.814 1.00 22.13 A C ATOM 6171 CG PHE A 400 35.471 −23.874 16.008 1.00 24.27 A C ATOM 6172 CD1 PHE A 400 36.709 −23.344 16.297 1.00 25.15 A C ATOM 6174 CE1 PHE A 400 37.825 −23.700 15.562 1.00 27.59 A C ATOM 6176 CZ PHE A 400 37.706 −24.594 14.508 1.00 24.77 A C ATOM 6178 CE2 PHE A 400 36.485 −25.112 14.212 1.00 26.28 A C ATOM 6180 CD2 PHE A 400 35.370 −24.765 14.961 1.00 27.15 A C ATOM 6182 C PHE A 400 33.607 −22.031 14.942 1.00 22.50 A C ATOM 6183 O PHE A 400 34.444 −21.431 14.291 1.00 24.88 A O ATOM 6185 N ASP A 401 32.592 −22.671 14.386 1.00 23.39 A N ATOM 6186 CA ASP A 401 32.403 −22.692 12.937 1.00 24.28 A C ATOM 6188 CB ASP A 401 31.188 −23.522 12.564 1.00 23.91 A C ATOM 6191 CG ASP A 401 31.358 −24.979 12.941 1.00 28.76 A C ATOM 6192 OD1 ASP A 401 32.437 −25.532 12.673 1.00 27.85 A O ATOM 6193 OD2 ASP A 401 30.423 −25.559 13.533 1.00 36.29 A O ATOM 6194 C ASP A 401 32.284 −21.294 12.338 1.00 25.29 A C ATOM 6195 O ASP A 401 32.891 −21.033 11.298 1.00 24.72 A O ATOM 6197 N ASP A 402 31.512 −20.417 12.991 1.00 25.45 A N ATOM 6198 CA ASP A 402 31.359 −19.016 12.557 1.00 25.75 A C ATOM 6200 CB ASP A 402 30.248 −18.298 13.337 1.00 24.45 A C ATOM 6203 CG ASP A 402 28.864 −18.808 13.005 1.00 31.45 A C ATOM 6204 OD1 ASP A 402 28.671 −19.403 11.913 1.00 37.61 A O ATOM 6205 OD2 ASP A 402 27.959 −18.589 13.847 1.00 37.38 A O ATOM 6206 C ASP A 402 32.664 −18.196 12.708 1.00 25.83 A C ATOM 6207 O ASP A 402 33.042 −17.481 11.782 1.00 26.75 A O ATOM 6209 N TYR A 403 33.329 −18.301 13.861 1.00 23.13 A N ATOM 6210 CA TYR A 403 34.579 −17.565 14.082 1.00 24.59 A C ATOM 6212 CB TYR A 403 35.098 −17.728 15.511 1.00 24.61 A C ATOM 6215 CG TYR A 403 36.334 −16.894 15.730 1.00 28.40 A C ATOM 6216 CD1 TYR A 403 36.236 −15.532 15.998 1.00 32.59 A C ATOM 6218 CE1 TYR A 403 37.367 −14.758 16.178 1.00 34.56 A C ATOM 6220 CZ TYR A 403 38.607 −15.340 16.074 1.00 33.11 A C ATOM 6221 OH TYR A 403 39.730 −14.586 16.261 1.00 39.07 A O ATOM 6223 CE2 TYR A 403 38.730 −16.683 15.799 1.00 36.49 A C ATOM 6225 CD2 TYR A 403 37.598 −17.450 15.621 1.00 29.76 A C ATOM 6227 C TYR A 403 35.694 −17.999 13.161 1.00 24.10 A C ATOM 6228 O TYR A 403 36.406 −17.162 12.585 1.00 24.93 A O ATOM 6230 N PHE A 404 35.873 −19.315 13.073 1.00 23.56 A N ATOM 6231 CA PHE A 404 36.904 −19.899 12.235 1.00 22.27 A C ATOM 6233 CB PHE A 404 37.024 −21.394 12.494 1.00 21.27 A C ATOM 6236 CG PHE A 404 38.023 −22.073 11.628 1.00 21.41 A C ATOM 6237 CD1 PHE A 404 39.364 −21.747 11.713 1.00 23.52 A C ATOM 6239 CE1 PHE A 404 40.280 −22.365 10.908 1.00 20.75 A C ATOM 6241 CZ PHE A 404 39.877 −23.310 10.012 1.00 19.51 A C ATOM 6243 CE2 PHE A 404 38.550 −23.641 9.903 1.00 24.73 A C ATOM 6245 CD2 PHE A 404 37.627 −23.022 10.701 1.00 25.71 A C ATOM 6247 C PHE A 404 36.611 −19.655 10.769 1.00 23.34 A C ATOM 6248 O PHE A 404 37.539 −19.400 9.990 1.00 24.39 A O ATOM 6250 N GLY A 405 35.338 −19.738 10.387 1.00 23.21 A N ATOM 6251 CA GLY A 405 34.937 −19.437 9.004 1.00 24.54 A C ATOM 6254 C GLY A 405 35.401 −18.050 8.580 1.00 24.99 A C ATOM 6255 O GLY A 405 35.994 −17.879 7.533 1.00 28.71 A O ATOM 6257 N ASN A 406 35.145 −17.062 9.423 1.00 24.64 A N ATOM 6258 CA ASN A 406 35.613 −15.697 9.202 1.00 23.03 A C ATOM 6260 CB ASN A 406 34.943 −14.761 10.193 1.00 22.91 A C ATOM 6263 CG ASN A 406 35.200 −13.294 9.881 1.00 22.65 A C ATOM 6264 OD1 ASN A 406 34.666 −12.755 8.927 1.00 21.35 A O ATOM 6265 ND2 ASN A 406 35.999 −12.646 10.709 1.00 10.69 A N ATOM 6268 C ASN A 406 37.137 −15.589 9.322 1.00 22.38 A C ATOM 6269 O ASN A 406 37.770 −14.927 8.512 1.00 22.73 A O ATOM 6271 N ALA A 407 37.717 −16.273 10.311 1.00 21.38 A N ATOM 6272 CA ALA A 407 39.138 −16.136 10.630 1.00 19.47 A C ATOM 6274 CB ALA A 407 39.437 −16.829 11.920 1.00 18.28 A C ATOM 6278 C ALA A 407 40.118 −16.626 9.546 1.00 21.80 A C ATOM 6279 O ALA A 407 41.210 −16.042 9.394 1.00 20.64 A O ATOM 6281 N TRP A 408 39.767 −17.691 8.817 1.00 20.25 A N ATOM 6282 CA TRP A 408 40.648 −18.153 7.738 1.00 21.62 A C ATOM 6284 CB TRP A 408 40.410 −19.619 7.303 1.00 20.05 A C ATOM 6287 CG TRP A 408 39.101 −20.016 6.707 1.00 20.37 A C ATOM 6288 CD1 TRP A 408 38.120 −20.717 7.331 1.00 22.39 A C ATOM 6290 NE1 TRP A 408 37.081 −20.959 6.468 1.00 22.00 A N ATOM 6292 CE2 TRP A 408 37.389 −20.445 5.242 1.00 25.44 A C ATOM 6293 CD2 TRP A 408 38.661 −19.852 5.342 1.00 24.30 A C ATOM 6294 CE3 TRP A 408 39.204 −19.239 4.215 1.00 21.11 A C ATOM 6296 CZ3 TRP A 408 38.484 −19.231 3.054 1.00 23.35 A C ATOM 6298 CH2 TRP A 408 37.218 −19.843 2.972 1.00 25.47 A C ATOM 6300 CZ2 TRP A 408 36.656 −20.454 4.058 1.00 28.32 A C ATOM 6302 C TRP A 408 40.645 −17.193 6.560 1.00 21.64 A C ATOM 6303 O TRP A 408 41.626 −17.105 5.835 1.00 25.03 A O ATOM 6305 N LYS A 409 39.555 −16.457 6.393 1.00 21.99 A N ATOM 6306 CA LYS A 409 39.512 −15.343 5.452 1.00 20.54 A C ATOM 6308 CB LYS A 409 38.064 −14.918 5.204 1.00 21.65 A C ATOM 6311 CG LYS A 409 37.258 −15.966 4.401 1.00 26.50 A C ATOM 6314 CD LYS A 409 35.889 −15.427 3.920 1.00 37.40 A C ATOM 6317 CE LYS A 409 34.998 −16.525 3.284 1.00 37.80 A C ATOM 6320 NZ LYS A 409 34.458 −17.478 4.334 1.00 45.51 A N ATOM 6324 C LYS A 409 40.336 −14.142 5.947 1.00 20.29 A C ATOM 6325 O LYS A 409 41.041 −13.522 5.166 1.00 19.77 A O ATOM 6327 N SER A 410 40.238 −13.822 7.240 1.00 20.14 A N ATOM 6328 CA SER A 410 40.942 −12.689 7.809 1.00 20.34 A C ATOM 6330 CB SER A 410 40.355 −12.306 9.171 1.00 21.88 A C ATOM 6333 OG SER A 410 40.776 −13.162 10.222 1.00 22.69 A O ATOM 6335 C SER A 410 42.444 −12.915 7.940 1.00 21.36 A C ATOM 6336 O SER A 410 43.181 −11.974 8.121 1.00 25.27 A O ATOM 6338 N SER A 411 42.894 −14.159 7.853 1.00 21.66 A N ATOM 6339 CA SER A 411 44.323 −14.472 7.749 1.00 19.61 A C ATOM 6341 CB SER A 411 44.498 −15.982 7.515 1.00 20.08 A C ATOM 6344 OG SER A 411 44.053 −16.360 6.210 1.00 16.88 A O ATOM 6346 C SER A 411 44.978 −13.744 6.578 1.00 19.91 A C ATOM 6347 O SER A 411 46.162 −13.450 6.635 1.00 21.95 A O ATOM 6349 N SER A 412 44.191 −13.545 5.514 1.00 21.23 A N ATOM 6350 CA SER A 412 44.583 −13.016 4.210 1.00 22.76 A C ATOM 6352 CB SER A 412 45.556 −11.838 4.292 1.00 23.35 A C ATOM 6355 OG SER A 412 46.887 −12.243 4.513 1.00 23.24 A O ATOM 6357 C SER A 412 45.145 −14.076 3.279 1.00 24.50 A C ATOM 6358 O SER A 412 45.498 −13.765 2.140 1.00 25.91 A O ATOM 6360 N GLY A 413 45.193 −15.324 3.726 1.00 21.84 A N ATOM 6361 CA GLY A 413 45.631 −16.399 2.840 1.00 21.18 A C ATOM 6364 C GLY A 413 44.883 −16.434 1.512 1.00 21.67 A C ATOM 6365 O GLY A 413 45.486 −16.563 0.421 1.00 23.81 A O ATOM 6367 N PRO A 414 43.563 −16.338 1.573 1.00 19.53 A N ATOM 6368 CA PRO A 414 42.874 −16.401 0.317 1.00 20.30 A C ATOM 6370 CB PRO A 414 41.403 −16.323 0.743 1.00 21.26 A C ATOM 6373 CG PRO A 414 41.405 −16.957 2.086 1.00 19.47 A C ATOM 6376 CD PRO A 414 42.621 −16.372 2.708 1.00 18.13 A C ATOM 6379 C PRO A 414 43.244 −15.251 −0.621 1.00 20.27 A C ATOM 6380 O PRO A 414 43.472 −15.460 −1.813 1.00 21.85 A O ATOM 6381 N LEU A 415 43.319 −14.047 −0.088 1.00 22.69 A N ATOM 6382 CA LEU A 415 43.651 −12.894 −0.914 1.00 21.21 A C ATOM 6384 CB LEU A 415 43.542 −11.617 −0.091 1.00 23.62 A C ATOM 6387 CG LEU A 415 44.014 −10.325 −0.761 1.00 25.57 A C ATOM 6389 CD1 LEU A 415 43.140 −9.131 −0.331 1.00 24.96 A C ATOM 6393 CD2 LEU A 415 45.473 −10.080 −0.413 1.00 23.56 A C ATOM 6397 C LEU A 415 45.037 −13.046 −1.495 1.00 20.90 A C ATOM 6398 O LEU A 415 45.251 −12.774 −2.673 1.00 20.89 A O ATOM 6400 N GLN A 416 45.991 −13.480 −0.682 1.00 20.64 A N ATOM 6401 CA GLN A 416 47.343 −13.694 −1.193 1.00 21.69 A C ATOM 6403 CB GLN A 416 48.251 −14.217 −0.111 1.00 22.06 A C ATOM 6406 CG GLN A 416 48.534 −13.218 0.973 1.00 22.59 A C ATOM 6409 CD GLN A 416 49.502 −13.765 1.993 1.00 26.11 A C ATOM 6410 OE1 GLN A 416 50.390 −14.547 1.671 1.00 29.66 A O ATOM 6411 NE2 GLN A 416 49.336 −13.354 3.230 1.00 25.39 A N ATOM 6414 C GLN A 416 47.377 −14.662 −2.355 1.00 22.17 A C ATOM 6415 O GLN A 416 48.115 −14.479 −3.326 1.00 23.08 A O ATOM 6417 N LEU A 417 46.557 −15.693 −2.258 1.00 22.31 A N ATOM 6418 CA LEU A 417 46.551 −16.738 −3.261 1.00 21.08 A C ATOM 6420 CB LEU A 417 45.990 −18.030 −2.654 1.00 21.91 A C ATOM 6423 CG LEU A 417 46.945 −18.669 −1.639 1.00 19.81 A C ATOM 6425 CD1 LEU A 417 46.344 −19.945 −1.113 1.00 14.21 A C ATOM 6429 CD2 LEU A 417 48.346 −18.927 −2.256 1.00 18.26 A C ATOM 6433 C LEU A 417 45.790 −16.309 −4.513 1.00 20.42 A C ATOM 6434 O LEU A 417 46.103 −16.788 −5.593 1.00 22.88 A O ATOM 6436 N VAL A 418 44.810 −15.411 −4.392 1.00 19.02 A N ATOM 6437 CA VAL A 418 44.225 −14.779 −5.577 1.00 18.67 A C ATOM 6439 CB VAL A 418 42.998 −13.900 −5.236 1.00 20.97 A C ATOM 6441 CG1 VAL A 418 41.818 −14.753 −4.788 1.00 18.15 A C ATOM 6445 CG2 VAL A 418 42.578 −13.054 −6.466 1.00 20.23 A C ATOM 6449 C VAL A 418 45.294 −13.951 −6.316 1.00 21.16 A C ATOM 6450 O VAL A 418 45.461 −14.083 −7.528 1.00 22.26 A O ATOM 6452 N PHE A 419 46.042 −13.109 −5.596 1.00 21.17 A N ATOM 6453 CA PHE A 419 47.119 −12.364 −6.258 1.00 21.54 A C ATOM 6455 CB PHE A 419 47.765 −11.331 −5.319 1.00 23.17 A C ATOM 6458 CG PHE A 419 46.958 −10.072 −5.184 1.00 21.42 A C ATOM 6459 CD1 PHE A 419 47.326 −8.931 −5.865 1.00 22.64 A C ATOM 6461 CE1 PHE A 419 46.556 −7.776 −5.772 1.00 25.28 A C ATOM 6463 CZ PHE A 419 45.400 −7.762 −5.000 1.00 19.63 A C ATOM 6465 CE2 PHE A 419 45.006 −8.907 −4.339 1.00 19.52 A C ATOM 6467 CD2 PHE A 419 45.780 −10.056 −4.431 1.00 16.56 A C ATOM 6469 C PHE A 419 48.170 −13.309 −6.836 1.00 23.38 A C ATOM 6470 O PHE A 419 48.675 −13.070 −7.931 1.00 25.01 A O ATOM 6472 N ALA A 420 48.485 −14.385 −6.112 1.00 23.32 A N ATOM 6473 CA ALA A 420 49.475 −15.361 −6.567 1.00 23.26 A C ATOM 6475 CB ALA A 420 49.690 −16.442 −5.494 1.00 23.21 A C ATOM 6479 C ALA A 420 49.055 −15.988 −7.887 1.00 23.77 A C ATOM 6480 O ALA A 420 49.844 −16.087 −8.828 1.00 25.95 A O ATOM 6482 N TYR A 421 47.794 −16.363 −7.978 1.00 23.54 A N ATOM 6483 CA TYR A 421 47.263 −16.960 −9.198 1.00 23.07 A C ATOM 6485 CB TYR A 421 45.749 −17.152 −9.089 1.00 21.91 A C ATOM 6488 CG TYR A 421 45.100 −17.619 −10.361 1.00 27.04 A C ATOM 6489 CD1 TYR A 421 44.986 −18.967 −10.667 1.00 27.50 A C ATOM 6491 CE1 TYR A 421 44.387 −19.382 −11.857 1.00 24.79 A C ATOM 6493 CZ TYR A 421 43.913 −18.448 −12.741 1.00 29.31 A C ATOM 6494 OH TYR A 421 43.313 −18.816 −13.933 1.00 31.42 A O ATOM 6496 CE2 TYR A 421 44.033 −17.116 −12.450 1.00 27.45 A C ATOM 6498 CD2 TYR A 421 44.619 −16.714 −11.274 1.00 28.49 A C ATOM 6500 C TYR A 421 47.595 −16.104 −10.417 1.00 24.43 A C ATOM 6501 O TYR A 421 48.121 −16.591 −11.394 1.00 24.22 A O ATOM 6503 N PHE A 422 47.276 −14.823 −10.369 1.00 26.68 A N ATOM 6504 CA PHE A 422 47.503 −13.956 −11.530 1.00 25.20 A C ATOM 6506 CB PHE A 422 46.767 −12.615 −11.366 1.00 24.18 A C ATOM 6509 CG PHE A 422 45.256 −12.751 −11.365 1.00 22.43 A C ATOM 6510 CD1 PHE A 422 44.575 −13.050 −12.530 1.00 24.26 A C ATOM 6512 CE1 PHE A 422 43.211 −13.195 −12.532 1.00 19.71 A C ATOM 6514 CZ PHE A 422 42.501 −13.018 −11.375 1.00 23.62 A C ATOM 6516 CE2 PHE A 422 43.173 −12.692 −10.206 1.00 23.66 A C ATOM 6518 CD2 PHE A 422 44.528 −12.584 −10.209 1.00 23.28 A C ATOM 6520 C PHE A 422 48.995 −13.758 −11.820 1.00 25.13 A C ATOM 6521 O PHE A 422 49.373 −13.524 −12.938 1.00 26.88 A O ATOM 6523 N ALA A 423 49.848 −13.890 −10.816 1.00 26.63 A N ATOM 6524 CA ALA A 423 51.276 −13.786 −11.044 1.00 25.44 A C ATOM 6526 CB ALA A 423 51.948 −13.230 −9.802 1.00 23.79 A C ATOM 6530 C ALA A 423 51.971 −15.094 −11.494 1.00 26.97 A C ATOM 6531 O ALA A 423 53.081 −15.036 −12.004 1.00 27.50 A O ATOM 6533 N VAL A 424 51.374 −16.264 −11.299 1.00 28.07 A N ATOM 6534 CA VAL A 424 52.066 −17.507 −11.685 1.00 29.42 A C ATOM 6536 CB VAL A 424 52.283 −18.495 −10.493 1.00 29.38 A C ATOM 6538 CG1 VAL A 424 52.977 −17.799 −9.333 1.00 25.33 A C ATOM 6542 CG2 VAL A 424 50.996 −19.113 −10.041 1.00 22.76 A C ATOM 6546 C VAL A 424 51.408 −18.251 −12.844 1.00 33.66 A C ATOM 6547 O VAL A 424 52.053 −19.079 −13.490 1.00 35.50 A O ATOM 6549 N VAL A 425 50.146 −17.965 −13.127 1.00 35.54 A N ATOM 6550 CA VAL A 425 49.462 −18.645 −14.216 1.00 39.97 A C ATOM 6552 CB VAL A 425 47.958 −18.802 −13.917 1.00 41.70 A C ATOM 6554 CG1 VAL A 425 47.191 −19.173 −15.166 1.00 40.48 A C ATOM 6558 CG2 VAL A 425 47.747 −19.848 −12.808 1.00 38.62 A C ATOM 6562 C VAL A 425 49.640 −17.919 −15.547 1.00 43.30 A C ATOM 6563 O VAL A 425 49.391 −16.728 −15.649 1.00 45.08 A O ATOM 6565 N GLN A 426 50.020 −18.681 −16.567 1.00 47.38 A N ATOM 6566 CA GLN A 426 50.299 −18.169 −17.911 1.00 50.63 A C ATOM 6568 CB GLN A 426 50.890 −19.311 −18.767 1.00 52.86 A C ATOM 6571 CG GLN A 426 51.846 −18.861 −19.889 1.00 62.22 A C ATOM 6574 CD GLN A 426 52.389 −20.034 −20.719 1.00 68.68 A C ATOM 6575 OE1 GLN A 426 52.756 −21.079 −20.174 1.00 74.04 A O ATOM 6576 NE2 GLN A 426 52.439 −19.857 −22.039 1.00 69.99 A N ATOM 6579 C GLN A 426 49.041 −17.602 −18.573 1.00 48.57 A C ATOM 6580 O GLN A 426 49.002 −16.441 −18.976 1.00 49.10 A O ATOM 6582 N ASN A 427 48.014 −18.437 −18.675 1.00 46.60 A N ATOM 6583 CA ASN A 427 46.748 −18.043 −19.265 1.00 44.60 A C ATOM 6585 CB ASN A 427 46.429 −18.906 −20.487 1.00 44.23 A C ATOM 6588 CG ASN A 427 47.362 −18.637 −21.657 1.00 46.94 A C ATOM 6589 OD1 ASN A 427 47.181 −17.674 −22.416 1.00 45.67 A O ATOM 6590 ND2 ASN A 427 48.363 −19.501 −21.818 1.00 41.48 A N ATOM 6593 C ASN A 427 45.649 −18.200 −18.231 1.00 42.84 A C ATOM 6594 O ASN A 427 45.421 −19.292 −17.709 1.00 42.87 A O ATOM 6596 N ILE A 428 44.957 −17.105 −17.973 1.00 40.25 A N ATOM 6597 CA ILE A 428 43.853 −17.067 −17.038 1.00 40.59 A C ATOM 6599 CB ILE A 428 43.459 −15.599 −16.777 1.00 41.62 A C ATOM 6601 CG1 ILE A 428 44.629 −14.848 −16.128 1.00 40.01 A C ATOM 6604 CD1 ILE A 428 44.658 −13.322 −16.465 1.00 35.27 A C ATOM 6608 CG2 ILE A 428 42.222 −15.507 −15.910 1.00 44.80 A C ATOM 6612 C ILE A 428 42.693 −17.839 −17.658 1.00 41.08 A C ATOM 6613 O ILE A 428 42.553 −17.846 −18.880 1.00 42.37 A O ATOM 6615 N LYS A 429 41.896 −18.518 −16.832 1.00 40.25 A N ATOM 6616 CA LYS A 429 40.658 −19.174 −17.289 1.00 39.88 A C ATOM 6618 CB LYS A 429 40.765 −20.701 −17.218 1.00 40.54 A C ATOM 6621 CG LYS A 429 41.990 −21.287 −17.914 1.00 44.77 A C ATOM 6624 CD LYS A 429 42.057 −22.807 −17.758 1.00 51.10 A C ATOM 6627 CE LYS A 429 43.171 −23.422 −18.624 1.00 55.81 A C ATOM 6630 NZ LYS A 429 43.150 −24.926 −18.619 1.00 55.50 A N ATOM 6634 C LYS A 429 39.503 −18.725 −16.422 1.00 38.57 A C ATOM 6635 O LYS A 429 39.622 −18.686 −15.203 1.00 37.64 A O ATOM 6637 N LYS A 430 38.387 −18.402 −17.057 1.00 39.36 A N ATOM 6638 CA LYS A 430 37.202 −17.914 −16.377 1.00 41.11 A C ATOM 6640 CB LYS A 430 36.047 −17.755 −17.374 1.00 42.76 A C ATOM 6643 CG LYS A 430 34.811 −17.033 −16.805 1.00 52.15 A C ATOM 6646 CD LYS A 430 33.595 −17.025 −17.779 1.00 62.30 A C ATOM 6649 CE LYS A 430 33.214 −18.434 −18.289 1.00 67.69 A C ATOM 6652 NZ LYS A 430 33.285 −19.518 −17.240 1.00 70.45 A N ATOM 6656 C LYS A 430 36.760 −18.829 −15.242 1.00 39.57 A C ATOM 6657 O LYS A 430 36.417 −18.359 −14.164 1.00 40.96 A O ATOM 6659 N GLU A 431 36.750 −20.128 −15.481 1.00 38.13 A N ATOM 6660 CA GLU A 431 36.268 −21.066 −14.481 1.00 38.67 A C ATOM 6662 CB GLU A 431 36.170 −22.473 −15.077 1.00 40.19 A C ATOM 6665 CG GLU A 431 35.497 −23.511 −14.161 1.00 48.81 A C ATOM 6668 CD GLU A 431 35.757 −24.965 −14.584 1.00 61.18 A C ATOM 6669 OE1 GLU A 431 36.689 −25.202 −15.394 1.00 63.32 A O ATOM 6670 OE2 GLU A 431 35.035 −25.871 −14.094 1.00 62.58 A O ATOM 6671 C GLU A 431 37.190 −21.073 −13.259 1.00 36.48 A C ATOM 6672 O GLU A 431 36.734 −21.199 −12.129 1.00 36.23 A O ATOM 6674 N GLU A 432 38.488 −20.954 −13.497 1.00 33.62 A N ATOM 6675 CA GLU A 432 39.445 −20.894 −12.420 1.00 32.85 A C ATOM 6677 CB GLU A 432 40.866 −20.914 −12.983 1.00 33.14 A C ATOM 6680 CG GLU A 432 41.222 −22.249 −13.661 1.00 32.44 A C ATOM 6683 CD GLU A 432 42.707 −22.372 −14.031 1.00 39.53 A C ATOM 6684 OE1 GLU A 432 43.375 −21.332 −14.238 1.00 36.98 A O ATOM 6685 OE2 GLU A 432 43.201 −23.522 −14.119 1.00 43.09 A O ATOM 6686 C GLU A 432 39.184 −19.665 −11.532 1.00 32.20 A C ATOM 6687 O GLU A 432 39.045 −19.781 −10.320 1.00 30.88 A O ATOM 6689 N ILE A 433 39.068 −18.493 −12.134 1.00 32.33 A N ATOM 6690 CA ILE A 433 38.908 −17.281 −11.335 1.00 34.37 A C ATOM 6692 CB ILE A 433 39.317 −15.983 −12.109 1.00 33.78 A C ATOM 6694 CG1 ILE A 433 38.480 −15.704 −13.327 1.00 38.66 A C ATOM 6697 CD1 ILE A 433 39.103 −14.565 −14.169 1.00 38.73 A C ATOM 6701 CG2 ILE A 433 40.739 −16.106 −12.614 1.00 35.34 A C ATOM 6705 C ILE A 433 37.524 −17.235 −10.645 1.00 33.31 A C ATOM 6706 O ILE A 433 37.414 −16.838 −9.485 1.00 33.97 A O ATOM 6708 N GLU A 434 36.501 −17.744 −11.305 1.00 30.95 A N ATOM 6709 CA GLU A 434 35.221 −17.944 −10.643 1.00 32.93 A C ATOM 6711 CB GLU A 434 34.242 −18.683 −11.551 1.00 33.75 A C ATOM 6714 CG GLU A 434 32.961 −17.939 −11.781 1.00 46.39 A C ATOM 6717 CD GLU A 434 33.044 −17.044 −12.995 1.00 58.82 A C ATOM 6718 OE1 GLU A 434 32.768 −17.555 −14.111 1.00 63.42 A O ATOM 6719 OE2 GLU A 434 33.383 −15.842 −12.828 1.00 62.69 A O ATOM 6720 C GLU A 434 35.349 −18.777 −9.367 1.00 31.62 A C ATOM 6721 O GLU A 434 34.681 −18.501 −8.378 1.00 30.48 A O ATOM 6723 N ASN A 435 36.149 −19.844 −9.428 1.00 29.51 A N ATOM 6724 CA ASN A 435 36.342 −20.710 −8.285 1.00 27.90 A C ATOM 6726 CB ASN A 435 36.878 −22.070 −8.714 1.00 28.27 A C ATOM 6729 CG ASN A 435 35.756 −23.015 −9.168 1.00 33.33 A C ATOM 6730 OD1 ASN A 435 35.103 −23.671 −8.354 1.00 37.87 A O ATOM 6731 ND2 ASN A 435 35.524 −23.063 −10.466 1.00 29.41 A N ATOM 6734 C ASN A 435 37.212 −20.060 −7.199 1.00 25.58 A C ATOM 6735 O ASN A 435 36.985 −20.285 −6.037 1.00 23.42 A O ATOM 6737 N LEU A 436 38.163 −19.221 −7.582 1.00 25.17 A N ATOM 6738 CA LEU A 436 38.861 −18.411 −6.597 1.00 27.41 A C ATOM 6740 CB LEU A 436 39.909 −17.535 −7.240 1.00 26.64 A C ATOM 6743 CG LEU A 436 41.090 −18.252 −7.868 1.00 26.99 A C ATOM 6745 CD1 LEU A 436 42.017 −17.177 −8.425 1.00 26.84 A C ATOM 6749 CD2 LEU A 436 41.819 −19.140 −6.861 1.00 23.22 A C ATOM 6753 C LEU A 436 37.892 −17.536 −5.800 1.00 28.45 A C ATOM 6754 O LEU A 436 37.991 −17.504 −4.587 1.00 29.36 A O ATOM 6756 N GLN A 437 36.936 −16.891 −6.465 1.00 30.08 A N ATOM 6757 CA GLN A 437 35.973 −16.014 −5.778 1.00 32.71 A C ATOM 6759 CB GLN A 437 35.120 −15.210 −6.760 1.00 34.60 A C ATOM 6762 CG GLN A 437 35.934 −14.322 −7.670 1.00 40.35 A C ATOM 6765 CD GLN A 437 35.165 −13.112 −8.186 1.00 41.37 A C ATOM 6766 OE1 GLN A 437 34.156 −13.238 −8.889 1.00 39.37 A O ATOM 6767 NE2 GLN A 437 35.667 −11.931 −7.865 1.00 36.34 A N ATOM 6770 C GLN A 437 35.034 −16.781 −4.887 1.00 32.09 A C ATOM 6771 O GLN A 437 34.485 −16.215 −3.930 1.00 31.31 A O ATOM 6773 N LYS A 438 34.824 −18.058 −5.192 1.00 31.99 A N ATOM 6774 CA LYS A 438 34.012 −18.893 −4.314 1.00 33.99 A C ATOM 6776 CB LYS A 438 33.202 −19.913 −5.124 1.00 35.73 A C ATOM 6779 CG LYS A 438 32.247 −19.275 −6.153 1.00 45.89 A C ATOM 6782 CD LYS A 438 31.513 −20.316 −7.024 1.00 55.14 A C ATOM 6785 CE LYS A 438 30.386 −19.644 −7.869 1.00 63.38 A C ATOM 6788 NZ LYS A 438 29.546 −20.589 −8.694 1.00 60.75 A N ATOM 6792 C LYS A 438 34.865 −19.586 −3.236 1.00 31.23 A C ATOM 6793 O LYS A 438 34.392 −20.495 −2.582 1.00 32.53 A O ATOM 6795 N TYR A 439 36.106 −19.154 −3.025 1.00 29.33 A N ATOM 6796 CA TYR A 439 36.987 −19.827 −2.037 1.00 30.37 A C ATOM 6798 CB TYR A 439 36.580 −19.469 −0.619 1.00 30.63 A C ATOM 6801 CG TYR A 439 36.618 −18.009 −0.425 1.00 34.45 A C ATOM 6802 CD1 TYR A 439 37.797 −17.379 −0.140 1.00 34.10 A C ATOM 6804 CE1 TYR A 439 37.843 −16.017 0.018 1.00 46.73 A C ATOM 6806 CZ TYR A 439 36.696 −15.271 −0.125 1.00 42.16 A C ATOM 6807 OH TYR A 439 36.764 −13.915 0.022 1.00 47.04 A O ATOM 6809 CE2 TYR A 439 35.511 −15.873 −0.425 1.00 40.10 A C ATOM 6811 CD2 TYR A 439 35.471 −17.237 −0.574 1.00 40.92 A C ATOM 6813 C TYR A 439 37.069 −21.348 −2.189 1.00 28.38 A C ATOM 6814 O TYR A 439 36.845 −22.103 −1.260 1.00 29.86 A O ATOM 6816 N HIS A 440 37.398 −21.772 −3.393 1.00 28.22 A N ATOM 6817 CA HIS A 440 37.588 −23.162 −3.706 1.00 27.43 A C ATOM 6819 CB HIS A 440 38.015 −23.245 −5.154 1.00 27.12 A C ATOM 6822 CG HIS A 440 38.138 −24.635 −5.681 1.00 32.93 A C ATOM 6823 ND1 HIS A 440 39.347 −25.286 −5.776 1.00 33.95 A N ATOM 6825 CE1 HIS A 440 39.159 −26.476 −6.317 1.00 37.85 A C ATOM 6827 NE2 HIS A 440 37.873 −26.615 −6.576 1.00 39.10 A N ATOM 6829 CD2 HIS A 440 37.213 −25.475 −6.197 1.00 32.98 A C ATOM 6831 C HIS A 440 38.672 −23.786 −2.837 1.00 28.12 A C ATOM 6832 O HIS A 440 39.654 −23.120 −2.456 1.00 28.00 A O ATOM 6834 N ASP A 441 38.503 −25.080 −2.588 1.00 26.13 A N ATOM 6835 CA ASP A 441 39.400 −25.896 −1.767 1.00 26.61 A C ATOM 6837 CB ASP A 441 39.147 −27.387 −2.031 1.00 27.37 A C ATOM 6840 CG ASP A 441 37.763 −27.853 −1.564 1.00 29.75 A C ATOM 6841 OD1 ASP A 441 37.167 −27.195 −0.690 1.00 33.53 A O ATOM 6842 OD2 ASP A 441 37.280 −28.881 −2.096 1.00 42.48 A O ATOM 6843 C ASP A 441 40.881 −25.637 −1.966 1.00 25.58 A C ATOM 6844 O ASP A 441 41.660 −25.729 −1.031 1.00 24.77 A O ATOM 6846 N THR A 442 41.277 −25.366 −3.193 1.00 24.56 A N ATOM 6847 CA THR A 442 42.673 −25.189 −3.491 1.00 25.67 A C ATOM 6849 CB THR A 442 42.868 −24.892 −4.992 1.00 27.90 A C ATOM 6851 OG1 THR A 442 42.233 −25.923 −5.760 1.00 35.85 A O ATOM 6853 CG2 THR A 442 44.321 −24.853 −5.349 1.00 30.00 A C ATOM 6857 C THR A 442 43.224 −24.046 −2.635 1.00 24.91 A C ATOM 6858 O THR A 442 44.337 −24.143 −2.151 1.00 25.25 A O ATOM 6860 N ILE A 443 42.444 −22.980 −2.426 1.00 22.84 A N ATOM 6861 CA ILE A 443 42.947 −21.824 −1.701 1.00 22.34 A C ATOM 6863 CB ILE A 443 42.756 −20.489 −2.471 1.00 22.85 A C ATOM 6865 CG1 ILE A 443 41.323 −20.006 −2.467 1.00 21.22 A C ATOM 6868 CD1 ILE A 443 41.213 −18.584 −3.057 1.00 21.90 A C ATOM 6872 CG2 ILE A 443 43.241 −20.606 −3.900 1.00 18.47 A C ATOM 6876 C ILE A 443 42.392 −21.728 −0.294 1.00 23.52 A C ATOM 6877 O ILE A 443 43.045 −21.179 0.600 1.00 24.12 A O ATOM 6879 N SER A 444 41.229 −22.322 −0.060 1.00 24.10 A N ATOM 6880 CA SER A 444 40.649 −22.275 1.259 1.00 23.55 A C ATOM 6882 CB SER A 444 39.190 −22.705 1.213 1.00 25.69 A C ATOM 6885 OG SER A 444 39.087 −24.090 0.993 1.00 26.17 A O ATOM 6887 C SER A 444 41.453 −23.163 2.210 1.00 24.88 A C ATOM 6888 O SER A 444 41.745 −22.766 3.322 1.00 26.85 A O ATOM 6890 N ARG A 445 41.866 −24.344 1.776 1.00 22.69 A N ATOM 6891 CA ARG A 445 42.481 −25.273 2.732 1.00 23.70 A C ATOM 6893 CB ARG A 445 42.542 −26.686 2.164 1.00 24.49 A C ATOM 6896 CG ARG A 445 41.178 −27.309 2.168 1.00 24.68 A C ATOM 6899 CD ARG A 445 41.233 −28.614 1.536 1.00 35.00 A C ATOM 6902 NE ARG A 445 39.915 −29.227 1.462 1.00 41.73 A N ATOM 6904 CZ ARG A 445 39.533 −30.015 0.465 1.00 40.99 A C ATOM 6905 NH1 ARG A 445 40.365 −30.263 −0.544 1.00 41.35 A N ATOM 6908 NH2 ARG A 445 38.333 −30.562 0.478 1.00 38.98 A N ATOM 6911 C ARG A 445 43.820 −24.835 3.305 1.00 23.32 A C ATOM 6912 O ARG A 445 44.022 −24.930 4.514 1.00 23.11 A O ATOM 6914 N PRO A 446 44.722 −24.325 2.458 1.00 23.47 A N ATOM 6915 CA PRO A 446 45.955 −23.766 2.988 1.00 21.78 A C ATOM 6917 CB PRO A 446 46.703 −23.284 1.751 1.00 21.26 A C ATOM 6920 CG PRO A 446 46.082 −23.962 0.618 1.00 26.11 A C ATOM 6923 CD PRO A 446 44.688 −24.299 0.985 1.00 25.66 A C ATOM 6926 C PRO A 446 45.677 −22.599 3.903 1.00 20.98 A C ATOM 6927 O PRO A 446 46.397 −22.418 4.875 1.00 22.87 A O ATOM 6928 N SER A 447 44.620 −21.845 3.619 1.00 21.42 A N ATOM 6929 CA SER A 447 44.230 −20.731 4.469 1.00 20.70 A C ATOM 6931 CB SER A 447 43.183 −19.827 3.806 1.00 21.82 A C ATOM 6934 OG SER A 447 43.690 −19.313 2.556 1.00 20.36 A O ATOM 6936 C SER A 447 43.777 −21.209 5.822 1.00 22.31 A C ATOM 6937 O SER A 447 44.075 −20.554 6.820 1.00 23.84 A O ATOM 6939 N HIS A 448 43.104 −22.358 5.876 1.00 21.04 A N ATOM 6940 CA HIS A 448 42.712 −22.952 7.144 1.00 20.19 A C ATOM 6942 CB HIS A 448 42.004 −24.317 6.968 1.00 21.41 A C ATOM 6945 CG HIS A 448 40.675 −24.253 6.277 1.00 21.38 A C ATOM 6946 ND1 HIS A 448 39.944 −25.382 5.969 1.00 29.82 A N ATOM 6948 CE1 HIS A 448 38.812 −25.025 5.382 1.00 29.77 A C ATOM 6950 NE2 HIS A 448 38.790 −23.705 5.289 1.00 24.12 A N ATOM 6952 CD2 HIS A 448 39.939 −23.202 5.844 1.00 24.45 A C ATOM 6954 C HIS A 448 43.959 −23.180 7.969 1.00 20.74 A C ATOM 6955 O HIS A 448 44.002 −22.864 9.156 1.00 21.08 A O ATOM 6957 N ILE A 449 44.979 −23.756 7.340 1.00 23.35 A N ATOM 6958 CA ILE A 449 46.212 −24.095 8.052 1.00 23.10 A C ATOM 6960 CB ILE A 449 47.188 −24.850 7.162 1.00 24.84 A C ATOM 6962 CG1 ILE A 449 46.563 −26.145 6.663 1.00 26.29 A C ATOM 6965 CD1 ILE A 449 46.302 −27.059 7.721 1.00 29.80 A C ATOM 6969 CG2 ILE A 449 48.490 −25.168 7.926 1.00 20.98 A C ATOM 6973 C ILE A 449 46.928 −22.848 8.571 1.00 22.77 A C ATOM 6974 O ILE A 449 47.479 −22.863 9.658 1.00 23.35 A O ATOM 6976 N PHE A 450 46.918 −21.796 7.764 1.00 22.40 A N ATOM 6977 CA PHE A 450 47.527 −20.514 8.097 1.00 23.32 A C ATOM 6979 CB PHE A 450 47.411 −19.599 6.857 1.00 25.81 A C ATOM 6982 CG PHE A 450 47.936 −18.168 7.029 1.00 26.15 A C ATOM 6983 CD1 PHE A 450 48.744 −17.792 8.083 1.00 29.10 A C ATOM 6985 CE1 PHE A 450 49.178 −16.483 8.205 1.00 27.29 A C ATOM 6987 CZ PHE A 450 48.850 −15.548 7.238 1.00 27.02 A C ATOM 6989 CE2 PHE A 450 48.056 −15.914 6.167 1.00 30.51 A C ATOM 6991 CD2 PHE A 450 47.625 −17.214 6.062 1.00 23.58 A C ATOM 6993 C PHE A 450 46.854 −19.966 9.342 1.00 22.59 A C ATOM 6994 O PHE A 450 47.505 −19.733 10.370 1.00 23.10 A O ATOM 6996 N ARG A 451 45.538 −19.856 9.327 1.00 22.00 A N ATOM 6997 CA ARG A 451 44.884 −19.370 10.531 1.00 22.22 A C ATOM 6999 CB ARG A 451 43.396 −19.215 10.307 1.00 20.08 A C ATOM 7002 CG ARG A 451 42.583 −18.918 11.559 1.00 20.62 A C ATOM 7005 CD ARG A 451 43.123 −17.713 12.310 1.00 20.48 A C ATOM 7008 NE ARG A 451 43.009 −16.489 11.536 1.00 22.29 A N ATOM 7010 CZ ARG A 451 43.506 −15.318 11.908 1.00 22.48 A C ATOM 7011 NH1 ARG A 451 44.207 −15.207 13.027 1.00 20.34 A N ATOM 7014 NH2 ARG A 451 43.317 −14.259 11.149 1.00 22.06 A N ATOM 7017 C ARG A 451 45.183 −20.281 11.740 1.00 22.94 A C ATOM 7018 O ARG A 451 45.522 −19.806 12.825 1.00 22.52 A O ATOM 7020 N LEU A 452 45.044 −21.587 11.561 1.00 23.09 A N ATOM 7021 CA LEU A 452 45.208 −22.500 12.700 1.00 22.53 A C ATOM 7023 CB LEU A 452 44.799 −23.931 12.332 1.00 19.50 A C ATOM 7026 CG LEU A 452 43.313 −24.152 12.034 1.00 22.38 A C ATOM 7028 CD1 LEU A 452 43.089 −25.564 11.548 1.00 17.99 A C ATOM 7032 CD2 LEU A 452 42.403 −23.854 13.257 1.00 20.44 A C ATOM 7036 C LEU A 452 46.632 −22.453 13.278 1.00 22.42 A C ATOM 7037 O LEU A 452 46.793 −22.522 14.485 1.00 24.48 A O ATOM 7039 N CYS A 453 47.656 −22.340 12.433 1.00 22.44 A N ATOM 7040 CA CYS A 453 49.031 −22.312 12.933 1.00 24.59 A C ATOM 7042 CB CYS A 453 50.051 −22.425 11.804 1.00 26.01 A C ATOM 7045 SG CYS A 453 50.255 −24.066 11.075 1.00 27.17 A S ATOM 7047 C CYS A 453 49.283 −21.015 13.709 1.00 28.20 A C ATOM 7048 O CYS A 453 49.935 −21.023 14.753 1.00 31.95 A O ATOM 7050 N ASN A 454 48.768 −19.901 13.184 1.00 28.25 A N ATOM 7051 CA ASN A 454 48.874 −18.600 13.832 1.00 25.74 A C ATOM 7053 CB ASN A 454 48.292 −17.509 12.914 1.00 25.90 A C ATOM 7056 CG ASN A 454 48.465 −16.083 13.470 1.00 26.47 A C ATOM 7057 OD1 ASN A 454 48.991 −15.875 14.552 1.00 40.48 A O ATOM 7058 ND2 ASN A 454 48.002 −15.108 12.715 1.00 31.43 A N ATOM 7061 C ASN A 454 48.183 −18.595 15.180 1.00 26.43 A C ATOM 7062 O ASN A 454 48.774 −18.191 16.180 1.00 28.40 A O ATOM 7064 N ASP A 455 46.927 −19.024 15.205 1.00 26.39 A N ATOM 7065 CA ASP A 455 46.154 −19.022 16.434 1.00 25.96 A C ATOM 7067 CB ASP A 455 44.695 −19.399 16.185 1.00 26.38 A C ATOM 7070 CG ASP A 455 43.848 −18.229 15.635 1.00 30.58 A C ATOM 7071 OD1 ASP A 455 44.407 −17.210 15.161 1.00 23.66 A O ATOM 7072 OD2 ASP A 455 42.597 −18.359 15.672 1.00 27.94 A O ATOM 7073 C ASP A 455 46.775 −19.977 17.451 1.00 28.81 A C ATOM 7074 O ASP A 455 46.716 −19.705 18.659 1.00 29.70 A O ATOM 7076 N LEU A 456 47.368 −21.081 16.982 1.00 28.29 A N ATOM 7077 CA LEU A 456 48.072 −21.997 17.886 1.00 29.09 A C ATOM 7079 CB LEU A 456 48.609 −23.237 17.180 1.00 28.53 A C ATOM 7082 CG LEU A 456 47.613 −24.345 16.893 1.00 30.92 A C ATOM 7084 CD1 LEU A 456 48.213 −25.380 15.920 1.00 27.62 A C ATOM 7088 CD2 LEU A 456 47.182 −24.972 18.197 1.00 26.10 A C ATOM 7092 C LEU A 456 49.240 −21.292 18.552 1.00 30.48 A C ATOM 7093 O LEU A 456 49.465 −21.492 19.733 1.00 30.20 A O ATOM 7095 N ALA A 457 49.965 −20.458 17.807 1.00 30.94 A N ATOM 7096 CA ALA A 457 51.170 −19.838 18.350 1.00 30.89 A C ATOM 7098 CB ALA A 457 51.906 −19.078 17.293 1.00 28.28 A C ATOM 7102 C ALA A 457 50.847 −18.917 19.515 1.00 32.02 A C ATOM 7103 O ALA A 457 51.601 −18.841 20.466 1.00 34.01 A O ATOM 7105 N SER A 458 49.728 −18.222 19.441 1.00 34.20 A N ATOM 7106 CA SER A 458 49.383 −17.264 20.468 1.00 35.38 A C ATOM 7108 CB SER A 458 48.963 −15.943 19.823 1.00 36.92 A C ATOM 7111 OG SER A 458 47.792 −16.106 19.042 1.00 42.95 A O ATOM 7113 C SER A 458 48.282 −17.746 21.385 1.00 34.92 A C ATOM 7114 O SER A 458 47.901 −17.026 22.295 1.00 37.00 A O ATOM 7116 N ALA A 459 47.772 −18.955 21.178 1.00 34.97 A N ATOM 7117 CA ALA A 459 46.608 −19.381 21.934 1.00 34.82 A C ATOM 7119 CB ALA A 459 46.246 −20.833 21.642 1.00 33.75 A C ATOM 7123 C ALA A 459 46.827 −19.195 23.424 1.00 36.34 A C ATOM 7124 O ALA A 459 46.042 −18.506 24.078 1.00 34.86 A O ATOM 7126 N SER A 460 47.892 −19.805 23.948 1.00 39.24 A N ATOM 7127 CA SER A 460 48.081 −19.909 25.403 1.00 42.73 A C ATOM 7129 CB SER A 460 49.266 −20.832 25.765 1.00 43.60 A C ATOM 7132 OG SER A 460 50.520 −20.221 25.514 1.00 50.63 A O ATOM 7134 C SER A 460 48.188 −18.543 26.093 1.00 42.82 A C ATOM 7135 O SER A 460 47.591 −18.342 27.150 1.00 45.33 A O ATOM 7137 N ALA A 461 48.894 −17.598 25.482 1.00 43.05 A N ATOM 7138 CA ALA A 461 49.000 −16.245 26.037 1.00 43.65 A C ATOM 7140 CB ALA A 461 50.032 −15.414 25.263 1.00 42.89 A C ATOM 7144 C ALA A 461 47.647 −15.539 26.035 1.00 44.95 A C ATOM 7145 O ALA A 461 47.237 −14.969 27.045 1.00 46.39 A O ATOM 7147 N GLU A 462 46.947 −15.588 24.905 1.00 45.01 A N ATOM 7148 CA GLU A 462 45.666 −14.906 24.787 1.00 43.89 A C ATOM 7150 CB GLU A 462 45.159 −14.966 23.346 1.00 44.36 A C ATOM 7153 CG GLU A 462 46.045 −14.140 22.394 1.00 46.73 A C ATOM 7156 CD GLU A 462 45.617 −14.211 20.936 1.00 48.39 A C ATOM 7157 OE1 GLU A 462 44.548 −14.792 20.655 1.00 52.33 A O ATOM 7158 OE2 GLU A 462 46.361 −13.686 20.071 1.00 51.40 A O ATOM 7159 C GLU A 462 44.653 −15.472 25.763 1.00 42.95 A C ATOM 7160 O GLU A 462 43.856 −14.731 26.336 1.00 43.58 A O ATOM 7162 N ILE A 463 44.710 −16.776 25.985 1.00 42.70 A N ATOM 7163 CA ILE A 463 43.782 −17.436 26.897 1.00 44.06 A C ATOM 7165 CB ILE A 463 43.862 −18.971 26.773 1.00 43.11 A C ATOM 7167 CG1 ILE A 463 43.216 −19.427 25.461 1.00 43.65 A C ATOM 7170 CD1 ILE A 463 43.585 −20.854 25.026 1.00 35.99 A C ATOM 7174 CG2 ILE A 463 43.180 −19.641 27.948 1.00 43.57 A C ATOM 7178 C ILE A 463 44.055 −17.028 28.344 1.00 46.68 A C ATOM 7179 O ILE A 463 43.119 −16.877 29.134 1.00 47.89 A O ATOM 7181 N ALA A 464 45.334 −16.854 28.678 1.00 47.67 A N ATOM 7182 CA ALA A 464 45.744 −16.469 30.028 1.00 48.52 A C ATOM 7184 CB ALA A 464 47.240 −16.690 30.214 1.00 47.57 A C ATOM 7188 C ALA A 464 45.365 −15.013 30.335 1.00 49.52 A C ATOM 7189 O ALA A 464 45.060 −14.690 31.477 1.00 49.39 A O ATOM 7191 N ARG A 465 45.362 −14.153 29.311 1.00 50.44 A N ATOM 7192 CA ARG A 465 44.869 −12.768 29.442 1.00 51.06 A C ATOM 7194 CB ARG A 465 45.373 −11.889 28.285 1.00 51.52 A C ATOM 7197 CG ARG A 465 46.878 −11.770 28.142 1.00 55.59 A C ATOM 7200 CD ARG A 465 47.250 −10.670 27.135 1.00 58.49 A C ATOM 7203 NE ARG A 465 48.351 −11.095 26.268 1.00 64.38 A N ATOM 7205 CZ ARG A 465 48.272 −11.296 24.947 1.00 68.81 A C ATOM 7206 NH1 ARG A 465 47.138 −11.087 24.269 1.00 68.12 A N ATOM 7209 NH2 ARG A 465 49.356 −11.696 24.282 1.00 69.02 A N ATOM 7212 C ARG A 465 43.330 −12.663 29.474 1.00 50.68 A C ATOM 7213 O ARG A 465 42.785 −11.559 29.542 1.00 50.12 A O ATOM 7215 N GLY A 466 42.635 −13.795 29.397 1.00 51.02 A N ATOM 7216 CA GLY A 466 41.175 −13.811 29.340 1.00 50.69 A C ATOM 7219 C GLY A 466 40.582 −13.347 28.015 1.00 49.88 A C ATOM 7220 O GLY A 466 39.478 −12.817 27.989 1.00 50.15 A O ATOM 7222 N GLU A 467 41.304 −13.545 26.914 1.00 49.42 A N ATOM 7223 CA GLU A 467 40.783 −13.204 25.591 1.00 48.91 A C ATOM 7225 CB GLU A 467 41.897 −12.706 24.677 1.00 49.79 A C ATOM 7228 CG GLU A 467 42.400 −11.308 25.017 1.00 54.31 A C ATOM 7231 CD GLU A 467 43.488 −10.836 24.059 1.00 62.07 A C ATOM 7232 OE1 GLU A 467 43.370 −11.106 22.831 1.00 58.12 A O ATOM 7233 OE2 GLU A 467 44.457 −10.198 24.543 1.00 65.78 A O ATOM 7234 C GLU A 467 40.046 −14.372 24.923 1.00 46.84 A C ATOM 7235 O GLU A 467 40.258 −15.543 25.245 1.00 46.20 A O ATOM 7237 N THR A 468 39.182 −14.009 23.983 1.00 44.02 A N ATOM 7238 CA THR A 468 38.326 −14.934 23.255 1.00 41.85 A C ATOM 7240 CB THR A 468 36.893 −14.390 23.234 1.00 41.87 A C ATOM 7242 OG1 THR A 468 36.268 −14.693 24.475 1.00 44.70 A O ATOM 7244 CG2 THR A 468 36.079 −14.983 22.064 1.00 43.08 A C ATOM 7248 C THR A 468 38.732 −15.112 21.793 1.00 39.84 A C ATOM 7249 O THR A 468 38.459 −16.149 21.206 1.00 40.48 A O ATOM 7251 N ALA A 469 39.366 −14.098 21.210 1.00 36.45 A N ATOM 7252 CA ALA A 469 39.501 −14.004 19.772 1.00 35.32 A C ATOM 7254 CB ALA A 469 39.721 −12.524 19.353 1.00 34.04 A C ATOM 7258 C ALA A 469 40.636 −14.890 19.278 1.00 32.68 A C ATOM 7259 O ALA A 469 41.677 −14.392 18.837 1.00 33.79 A O ATOM 7261 N ASN A 470 40.399 −16.201 19.338 1.00 29.47 A N ATOM 7262 CA ASN A 470 41.373 −17.233 18.951 1.00 27.64 A C ATOM 7264 CB ASN A 470 42.374 −17.461 20.088 1.00 27.10 A C ATOM 7267 CG ASN A 470 43.550 −18.304 19.660 1.00 28.28 A C ATOM 7268 OD1 ASN A 470 43.450 −19.524 19.605 1.00 34.80 A O ATOM 7269 ND2 ASN A 470 44.676 −17.657 19.346 1.00 30.77 A N ATOM 7272 C ASN A 470 40.651 −18.546 18.607 1.00 27.38 A C ATOM 7273 O ASN A 470 39.675 −18.909 19.274 1.00 28.84 A O ATOM 7275 N SER A 471 41.115 −19.259 17.580 1.00 25.73 A N ATOM 7276 CA SER A 471 40.413 −20.476 17.127 1.00 25.56 A C ATOM 7278 CB SER A 471 41.033 −21.026 15.831 1.00 24.86 A C ATOM 7281 OG SER A 471 40.941 −20.066 14.773 1.00 24.10 A O ATOM 7283 C SER A 471 40.387 −21.555 18.208 1.00 25.57 A C ATOM 7284 O SER A 471 39.370 −22.234 18.392 1.00 28.49 A O ATOM 7286 N VAL A 472 41.487 −21.689 18.940 1.00 24.63 A N ATOM 7287 CA VAL A 472 41.573 −22.638 20.058 1.00 24.83 A C ATOM 7289 CB VAL A 472 42.976 −22.647 20.681 1.00 24.78 A C ATOM 7291 CG1 VAL A 472 43.062 −23.699 21.804 1.00 24.97 A C ATOM 7295 CG2 VAL A 472 44.025 −22.919 19.612 1.00 24.81 A C ATOM 7299 C VAL A 472 40.585 −22.302 21.161 1.00 25.99 A C ATOM 7300 O VAL A 472 39.878 −23.166 21.682 1.00 27.14 A O ATOM 7302 N SER A 473 40.548 −21.027 21.517 1.00 28.17 A N ATOM 7303 CA SER A 473 39.639 −20.538 22.539 1.00 27.38 A C ATOM 7305 CB SER A 473 39.877 −19.048 22.775 1.00 28.17 A C ATOM 7308 OG SER A 473 38.904 −18.546 23.666 1.00 36.50 A O ATOM 7310 C SER A 473 38.199 −20.785 22.134 1.00 26.74 A C ATOM 7311 O SER A 473 37.391 −21.244 22.942 1.00 26.77 A O ATOM 7313 N CYS A 474 37.872 −20.526 20.874 1.00 26.84 A N ATOM 7314 CA CYS A 474 36.513 −20.796 20.410 1.00 27.97 A C ATOM 7316 CB CYS A 474 36.248 −20.181 19.037 1.00 28.57 A C ATOM 7319 SG CYS A 474 36.094 −18.392 19.116 1.00 37.03 A S ATOM 7321 C CYS A 474 36.219 −22.290 20.396 1.00 27.00 A C ATOM 7322 O CYS A 474 35.094 −22.698 20.680 1.00 27.66 A O ATOM 7324 N TYR A 475 37.221 −23.106 20.076 1.00 26.04 A N ATOM 7325 CA TYR A 475 37.015 −24.547 20.082 1.00 25.17 A C ATOM 7327 CB TYR A 475 38.209 −25.290 19.486 1.00 24.75 A C ATOM 7330 CG TYR A 475 37.853 −26.656 18.929 1.00 28.24 A C ATOM 7331 CD1 TYR A 475 37.516 −26.821 17.587 1.00 32.56 A C ATOM 7333 CE1 TYR A 475 37.192 −28.071 17.081 1.00 36.43 A C ATOM 7335 CZ TYR A 475 37.199 −29.178 17.923 1.00 34.35 A C ATOM 7336 OH TYR A 475 36.886 −30.419 17.441 1.00 43.05 A O ATOM 7338 CE2 TYR A 475 37.533 −29.045 19.246 1.00 34.85 A C ATOM 7340 CD2 TYR A 475 37.858 −27.783 19.747 1.00 34.43 A C ATOM 7342 C TYR A 475 36.749 −25.003 21.518 1.00 26.37 A C ATOM 7343 O TYR A 475 35.869 −25.833 21.752 1.00 27.21 A O ATOM 7345 N MET A 476 37.481 −24.438 22.479 1.00 26.99 A N ATOM 7346 CA MET A 476 37.252 −24.759 23.901 1.00 26.98 A C ATOM 7348 CB MET A 476 38.202 −23.971 24.789 1.00 26.60 A C ATOM 7351 CG MET A 476 39.652 −24.384 24.656 1.00 30.73 A C ATOM 7354 SD MET A 476 40.740 −23.174 25.392 1.00 36.77 A S ATOM 7355 CE MET A 476 39.937 −22.903 26.995 1.00 30.88 A C ATOM 7359 C MET A 476 35.826 −24.444 24.319 1.00 26.91 A C ATOM 7360 O MET A 476 35.137 −25.270 24.911 1.00 28.08 A O ATOM 7362 N ARG A 477 35.386 −23.237 24.009 1.00 28.18 A N ATOM 7363 CA ARG A 477 34.058 −22.797 24.398 1.00 29.26 A C ATOM 7365 CB ARG A 477 33.880 −21.314 24.079 1.00 28.98 A C ATOM 7368 CG ARG A 477 32.520 −20.733 24.449 1.00 32.12 A C ATOM 7371 CD ARG A 477 32.537 −19.223 24.275 1.00 40.29 A C ATOM 7374 NE ARG A 477 32.786 −18.815 22.888 1.00 44.21 A N ATOM 7376 CZ ARG A 477 33.290 −17.637 22.514 1.00 46.88 A C ATOM 7377 NH1 ARG A 477 33.619 −16.721 23.420 1.00 48.90 A N ATOM 7380 NH2 ARG A 477 33.469 −17.371 21.222 1.00 45.48 A N ATOM 7383 C ARG A 477 32.971 −23.620 23.702 1.00 29.87 A C ATOM 7384 O ARG A 477 32.006 −24.035 24.352 1.00 31.04 A O ATOM 7386 N THR A 478 33.110 −23.852 22.397 1.00 28.61 A N ATOM 7387 CA THR A 478 32.044 −24.539 21.657 1.00 28.83 A C ATOM 7389 CB THR A 478 32.216 −24.430 20.131 1.00 28.55 A C ATOM 7391 OG1 THR A 478 32.238 −23.056 19.746 1.00 26.42 A O ATOM 7393 CG2 THR A 478 31.034 −25.107 19.407 1.00 30.41 A C ATOM 7397 C THR A 478 31.911 −26.014 22.075 1.00 28.98 A C ATOM 7398 O THR A 478 30.822 −26.467 22.400 1.00 28.85 A O ATOM 7400 N LYS A 479 33.013 −26.758 22.074 1.00 29.87 A N ATOM 7401 CA LYS A 479 32.969 −28.157 22.516 1.00 30.10 A C ATOM 7403 CB LYS A 479 34.143 −28.960 21.938 1.00 30.29 A C ATOM 7406 CG LYS A 479 34.249 −28.964 20.406 1.00 33.64 A C ATOM 7409 CD LYS A 479 33.118 −29.688 19.695 1.00 42.31 A C ATOM 7412 CE LYS A 479 33.306 −29.581 18.174 1.00 47.79 A C ATOM 7415 NZ LYS A 479 32.463 −30.535 17.381 1.00 47.97 A N ATOM 7419 C LYS A 479 32.936 −28.290 24.057 1.00 30.88 A C ATOM 7420 O LYS A 479 32.660 −29.360 24.576 1.00 30.47 A O ATOM 7422 N GLY A 480 33.223 −27.207 24.781 1.00 31.72 A N ATOM 7423 CA GLY A 480 33.206 −27.231 26.248 1.00 31.97 A C ATOM 7426 C GLY A 480 34.311 −28.088 26.843 1.00 31.96 A C ATOM 7427 O GLY A 480 34.044 −28.932 27.722 1.00 31.49 A O ATOM 7429 N ILE A 481 35.544 −27.847 26.382 1.00 29.64 A N ATOM 7430 CA ILE A 481 36.702 −28.660 26.747 1.00 29.31 A C ATOM 7432 CB ILE A 481 37.044 −29.668 25.621 1.00 29.72 A C ATOM 7434 CG1 ILE A 481 37.398 −28.940 24.302 1.00 30.04 A C ATOM 7437 CD1 ILE A 481 37.581 −29.865 23.094 1.00 25.37 A C ATOM 7441 CG2 ILE A 481 35.865 −30.602 25.391 1.00 29.26 A C ATOM 7445 C ILE A 481 37.926 −27.807 27.052 1.00 31.21 A C ATOM 7446 O ILE A 481 37.964 −26.613 26.746 1.00 32.82 A O ATOM 7448 N SER A 482 38.939 −28.439 27.634 1.00 32.10 A N ATOM 7449 CA SER A 482 40.162 −27.756 28.052 1.00 31.77 A C ATOM 7451 CB SER A 482 41.010 −28.718 28.874 1.00 32.78 A C ATOM 7454 OG SER A 482 41.130 −29.963 28.191 1.00 34.52 A O ATOM 7456 C SER A 482 41.000 −27.281 26.883 1.00 32.56 A C ATOM 7457 O SER A 482 40.839 −27.765 25.763 1.00 35.17 A O ATOM 7459 N GLU A 483 41.931 −26.369 27.161 1.00 32.02 A N ATOM 7460 CA GLU A 483 42.928 −25.941 26.186 1.00 33.48 A C ATOM 7462 CB GLU A 483 43.916 −24.948 26.815 1.00 33.20 A C ATOM 7465 CG GLU A 483 45.047 −24.524 25.877 1.00 33.67 A C ATOM 7468 CD GLU A 483 45.858 −23.351 26.389 1.00 40.22 A C ATOM 7469 OE1 GLU A 483 45.594 −22.861 27.519 1.00 43.03 A O ATOM 7470 OE2 GLU A 483 46.774 −22.916 25.657 1.00 38.81 A O ATOM 7471 C GLU A 483 43.714 −27.102 25.558 1.00 35.98 A C ATOM 7472 O GLU A 483 43.954 −27.120 24.335 1.00 37.13 A O ATOM 7474 N GLU A 484 44.134 −28.045 26.393 1.00 36.43 A N ATOM 7475 CA GLU A 484 44.980 −29.149 25.948 1.00 37.19 A C ATOM 7477 CB GLU A 484 45.523 −29.932 27.153 1.00 39.57 A C ATOM 7480 CG GLU A 484 46.686 −30.866 26.813 1.00 49.47 A C ATOM 7483 CD GLU A 484 47.292 −31.543 28.041 1.00 62.43 A C ATOM 7484 OE1 GLU A 484 47.606 −30.824 29.026 1.00 66.87 A O ATOM 7485 OE2 GLU A 484 47.459 −32.791 28.014 1.00 63.06 A O ATOM 7486 C GLU A 484 44.226 −30.084 25.005 1.00 35.28 A C ATOM 7487 O GLU A 484 44.768 −30.493 23.976 1.00 33.82 A O ATOM 7489 N LEU A 485 42.989 −30.433 25.351 1.00 33.95 A N ATOM 7490 CA LEU A 485 42.175 −31.227 24.425 1.00 33.76 A C ATOM 7492 CB LEU A 485 40.886 −31.745 25.069 1.00 34.55 A C ATOM 7495 CG LEU A 485 40.968 −33.207 25.551 1.00 39.74 A C ATOM 7497 CD1 LEU A 485 42.126 −33.394 26.541 1.00 40.89 A C ATOM 7501 CD2 LEU A 485 39.647 −33.669 26.180 1.00 42.87 A C ATOM 7505 C LEU A 485 41.870 −30.436 23.155 1.00 32.05 A C ATOM 7506 O LEU A 485 41.963 −30.972 22.062 1.00 30.76 A O ATOM 7508 N ALA A 486 41.522 −29.164 23.308 1.00 30.65 A N ATOM 7509 CA ALA A 486 41.225 −28.305 22.164 1.00 29.72 A C ATOM 7511 CB ALA A 486 40.771 −26.933 22.648 1.00 28.94 A C ATOM 7515 C ALA A 486 42.435 −28.176 21.228 1.00 30.16 A C ATOM 7516 O ALA A 486 42.310 −28.256 19.998 1.00 32.78 A O ATOM 7518 N THR A 487 43.607 −27.990 21.816 1.00 29.51 A N ATOM 7519 CA THR A 487 44.836 −27.889 21.068 1.00 29.35 A C ATOM 7521 CB THR A 487 46.016 −27.585 22.018 1.00 31.65 A C ATOM 7523 OG1 THR A 487 45.866 −26.262 22.551 1.00 34.58 A O ATOM 7525 CG2 THR A 487 47.356 −27.676 21.303 1.00 29.45 A C ATOM 7529 C THR A 487 45.083 −29.179 20.293 1.00 30.58 A C ATOM 7530 O THR A 487 45.510 −29.148 19.136 1.00 30.56 A O ATOM 7532 N GLU A 488 44.778 −30.311 20.912 1.00 30.73 A N ATOM 7533 CA GLU A 488 44.909 −31.596 20.251 1.00 31.69 A C ATOM 7535 CB GLU A 488 44.559 −32.726 21.226 1.00 34.61 A C ATOM 7538 CG GLU A 488 44.929 −34.158 20.782 1.00 42.91 A C ATOM 7541 CD GLU A 488 44.468 −35.230 21.805 1.00 51.83 A C ATOM 7542 OE1 GLU A 488 45.312 −36.038 22.257 1.00 53.97 A O ATOM 7543 OE2 GLU A 488 43.263 −35.252 22.169 1.00 57.42 A O ATOM 7544 C GLU A 488 43.990 −31.653 19.039 1.00 30.86 A C ATOM 7545 O GLU A 488 44.406 −32.077 17.959 1.00 30.25 A O ATOM 7547 N SER A 489 42.742 −31.226 19.216 1.00 28.77 A N ATOM 7548 CA SER A 489 41.759 −31.338 18.153 1.00 29.03 A C ATOM 7550 CB SER A 489 40.361 −31.004 18.646 1.00 28.33 A C ATOM 7553 OG SER A 489 40.002 −31.853 19.725 1.00 37.93 A O ATOM 7555 C SER A 489 42.124 −30.416 17.000 1.00 28.35 A C ATOM 7556 O SER A 489 41.905 −30.761 15.842 1.00 29.09 A O ATOM 7558 N VAL A 490 42.683 −29.257 17.327 1.00 27.58 A N ATOM 7559 CA VAL A 490 43.156 −28.332 16.308 1.00 27.37 A C ATOM 7561 CB VAL A 490 43.492 −26.971 16.899 1.00 27.54 A C ATOM 7563 CG1 VAL A 490 44.224 −26.084 15.887 1.00 23.38 A C ATOM 7567 CG2 VAL A 490 42.186 −26.322 17.351 1.00 26.23 A C ATOM 7571 C VAL A 490 44.308 −28.940 15.538 1.00 27.62 A C ATOM 7572 O VAL A 490 44.316 −28.869 14.319 1.00 28.81 A O ATOM 7574 N MET A 491 45.242 −29.589 16.225 1.00 29.11 A N ATOM 7575 CA MET A 491 46.328 −30.317 15.530 1.00 28.74 A C ATOM 7577 CB MET A 491 47.254 −31.019 16.529 1.00 32.05 A C ATOM 7580 CG MET A 491 48.053 −30.105 17.437 1.00 34.71 A C ATOM 7583 SD MET A 491 49.345 −29.289 16.533 1.00 54.88 A S ATOM 7584 CE MET A 491 50.240 −28.583 17.932 1.00 61.26 A C ATOM 7588 C MET A 491 45.764 −31.376 14.592 1.00 27.27 A C ATOM 7589 O MET A 491 46.251 −31.544 13.480 1.00 29.18 A O ATOM 7591 N ASN A 492 44.742 −32.102 15.042 1.00 24.90 A N ATOM 7592 CA ASN A 492 44.112 −33.108 14.194 1.00 24.42 A C ATOM 7594 CB ASN A 492 43.117 −33.973 14.976 1.00 27.09 A C ATOM 7597 CG ASN A 492 43.790 −34.834 16.076 1.00 32.10 A C ATOM 7598 OD1 ASN A 492 45.011 −35.022 16.111 1.00 36.38 A O ATOM 7599 ND2 ASN A 492 42.971 −35.342 16.983 1.00 29.67 A N ATOM 7602 C ASN A 492 43.416 −32.509 12.971 1.00 21.31 A C ATOM 7603 O ASN A 492 43.365 −33.141 11.924 1.00 19.60 A O ATOM 7605 N LEU A 493 42.864 −31.312 13.119 1.00 19.85 A N ATOM 7606 CA LEU A 493 42.208 −30.609 12.026 1.00 21.49 A C ATOM 7608 CB LEU A 493 41.438 −29.402 12.570 1.00 22.55 A C ATOM 7611 CG LEU A 493 40.562 −28.537 11.637 1.00 30.39 A C ATOM 7613 CD1 LEU A 493 39.640 −29.355 10.718 1.00 30.23 A C ATOM 7617 CD2 LEU A 493 39.693 −27.559 12.479 1.00 23.06 A C ATOM 7621 C LEU A 493 43.253 −30.196 10.988 1.00 20.61 A C ATOM 7622 O LEU A 493 43.024 −30.298 9.781 1.00 21.55 A O ATOM 7624 N ILE A 494 44.427 −29.800 11.463 1.00 19.95 A N ATOM 7625 CA ILE A 494 45.529 −29.519 10.574 1.00 21.52 A C ATOM 7627 CB ILE A 494 46.739 −28.978 11.329 1.00 20.44 A C ATOM 7629 CG1 ILE A 494 46.492 −27.511 11.724 1.00 22.83 A C ATOM 7632 CD1 ILE A 494 47.454 −27.023 12.815 1.00 19.27 A C ATOM 7636 CG2 ILE A 494 47.989 −29.041 10.489 1.00 18.64 A C ATOM 7640 C ILE A 494 45.898 −30.764 9.762 1.00 22.01 A C ATOM 7641 O ILE A 494 46.021 −30.688 8.539 1.00 25.12 A O ATOM 7643 N ASP A 495 46.087 −31.885 10.437 1.00 20.80 A N ATOM 7644 CA ASP A 495 46.397 −33.138 9.773 1.00 21.60 A C ATOM 7646 CB ASP A 495 46.473 −34.281 10.791 1.00 22.75 A C ATOM 7649 CG ASP A 495 47.682 −34.161 11.731 1.00 24.78 A C ATOM 7650 OD1 ASP A 495 48.662 −33.458 11.379 1.00 31.93 A O ATOM 7651 OD2 ASP A 495 47.641 −34.762 12.831 1.00 35.25 A O ATOM 7652 C ASP A 495 45.346 −33.462 8.740 1.00 22.09 A C ATOM 7653 O ASP A 495 45.666 −33.770 7.596 1.00 22.13 A O ATOM 7655 N GLU A 496 44.087 −33.342 9.134 1.00 23.17 A N ATOM 7656 CA GLU A 496 42.972 −33.693 8.258 1.00 25.14 A C ATOM 7658 CB GLU A 496 41.643 −33.501 8.984 1.00 26.79 A C ATOM 7661 CG GLU A 496 40.397 −33.761 8.177 1.00 35.71 A C ATOM 7664 CD GLU A 496 39.117 −33.280 8.886 1.00 44.71 A C ATOM 7665 OE1 GLU A 496 38.810 −33.788 9.987 1.00 47.95 A O ATOM 7666 OE2 GLU A 496 38.416 −32.402 8.328 1.00 50.58 A O ATOM 7667 C GLU A 496 43.032 −32.834 7.024 1.00 24.17 A C ATOM 7668 O GLU A 496 42.890 −33.344 5.909 1.00 23.57 A O ATOM 7670 N THR A 497 43.271 −31.535 7.232 1.00 23.07 A N ATOM 7671 CA THR A 497 43.327 −30.575 6.143 1.00 21.41 A C ATOM 7673 CB THR A 497 43.465 −29.157 6.674 1.00 22.58 A C ATOM 7675 OG1 THR A 497 42.381 −28.887 7.575 1.00 25.05 A O ATOM 7677 CG2 THR A 497 43.436 −28.162 5.551 1.00 17.59 A C ATOM 7681 C THR A 497 44.481 −30.901 5.175 1.00 22.39 A C ATOM 7682 O THR A 497 44.304 −30.840 3.961 1.00 20.87 A O ATOM 7684 N TRP A 498 45.641 −31.275 5.718 1.00 20.20 A N ATOM 7685 CA TRP A 498 46.743 −31.748 4.888 1.00 21.37 A C ATOM 7687 CB TRP A 498 47.973 −32.065 5.760 1.00 18.97 A C ATOM 7690 CG TRP A 498 48.874 −30.887 5.894 1.00 21.52 A C ATOM 7691 CD1 TRP A 498 48.969 −30.038 6.953 1.00 13.13 A C ATOM 7693 NE1 TRP A 498 49.885 −29.084 6.704 1.00 21.91 A N ATOM 7695 CE2 TRP A 498 50.399 −29.277 5.454 1.00 19.92 A C ATOM 7696 CD2 TRP A 498 49.780 −30.409 4.920 1.00 17.93 A C ATOM 7697 CE3 TRP A 498 50.135 −30.832 3.646 1.00 23.82 A C ATOM 7699 CZ3 TRP A 498 51.097 −30.125 2.961 1.00 24.54 A C ATOM 7701 CH2 TRP A 498 51.705 −29.007 3.526 1.00 25.21 A C ATOM 7703 CZ2 TRP A 498 51.375 −28.572 4.775 1.00 24.04 A C ATOM 7705 C TRP A 498 46.387 −32.963 4.013 1.00 19.42 A C ATOM 7706 O TRP A 498 46.715 −33.008 2.836 1.00 20.26 A O ATOM 7708 N LYS A 499 45.727 −33.944 4.588 1.00 19.66 A N ATOM 7709 CA LYS A 499 45.320 −35.113 3.824 1.00 21.18 A C ATOM 7711 CB LYS A 499 44.554 −36.105 4.701 1.00 20.73 A C ATOM 7714 CG LYS A 499 45.406 −36.825 5.766 1.00 20.29 A C ATOM 7717 CD LYS A 499 44.547 −37.888 6.525 1.00 21.48 A C ATOM 7720 CE LYS A 499 45.126 −38.323 7.841 1.00 21.99 A C ATOM 7723 NZ LYS A 499 44.166 −39.231 8.565 1.00 24.95 A N ATOM 7727 C LYS A 499 44.451 −34.701 2.655 1.00 20.41 A C ATOM 7728 O LYS A 499 44.532 −35.278 1.598 1.00 23.27 A O ATOM 7730 N LYS A 500 43.628 −33.688 2.842 1.00 20.82 A N ATOM 7731 CA LYS A 500 42.761 −33.233 1.779 1.00 23.10 A C ATOM 7733 CB LYS A 500 41.613 −32.392 2.351 1.00 24.87 A C ATOM 7736 CG LYS A 500 40.575 −33.199 3.110 1.00 24.42 A C ATOM 7739 CD LYS A 500 39.505 −32.282 3.741 1.00 34.06 A C ATOM 7742 CE LYS A 500 38.487 −33.073 4.598 1.00 33.59 A C ATOM 7745 NZ LYS A 500 37.318 −32.261 5.058 1.00 39.36 A N ATOM 7749 C LYS A 500 43.529 −32.461 0.703 1.00 22.13 A C ATOM 7750 O LYS A 500 43.233 −32.586 −0.469 1.00 23.08 A O ATOM 7752 N MET A 501 44.516 −31.665 1.088 1.00 22.16 A N ATOM 7753 CA MET A 501 45.324 −30.960 0.101 1.00 19.81 A C ATOM 7755 CB MET A 501 46.228 −29.944 0.770 1.00 19.32 A C ATOM 7758 CG MET A 501 45.516 −28.822 1.490 1.00 21.43 A C ATOM 7761 SD MET A 501 46.681 −27.490 1.974 1.00 27.05 A S ATOM 7762 CE MET A 501 47.856 −28.310 3.053 1.00 23.38 A C ATOM 7766 C MET A 501 46.176 −31.946 −0.698 1.00 18.61 A C ATOM 7767 O MET A 501 46.410 −31.758 −1.888 1.00 18.54 A O ATOM 7769 N ASN A 502 46.658 −32.991 −0.037 1.00 19.21 A N ATOM 7770 CA ASN A 502 47.440 −34.013 −0.717 1.00 18.62 A C ATOM 7772 CB ASN A 502 47.922 −35.069 0.277 1.00 18.18 A C ATOM 7775 CG ASN A 502 48.980 −34.544 1.216 1.00 20.41 A C ATOM 7776 OD1 ASN A 502 49.635 −33.522 0.933 1.00 20.85 A O ATOM 7777 ND2 ASN A 502 49.167 −35.244 2.353 1.00 14.88 A N ATOM 7780 C ASN A 502 46.629 −34.674 −1.815 1.00 20.92 A C ATOM 7781 O ASN A 502 47.140 −34.963 −2.889 1.00 21.10 A O ATOM 7783 N LYS A 503 45.361 −34.902 −1.548 1.00 21.59 A N ATOM 7784 CA LYS A 503 44.492 −35.487 −2.543 1.00 26.84 A C ATOM 7786 CB LYS A 503 43.158 −35.894 −1.907 1.00 25.07 A C ATOM 7789 CG LYS A 503 42.272 −36.688 −2.832 1.00 31.50 A C ATOM 7792 CD LYS A 503 41.048 −37.279 −2.122 1.00 37.63 A C ATOM 7795 CE LYS A 503 40.180 −38.027 −3.135 1.00 42.50 A C ATOM 7798 NZ LYS A 503 38.799 −38.319 −2.637 1.00 39.80 A N ATOM 7802 C LYS A 503 44.265 −34.554 −3.751 1.00 26.24 A C ATOM 7803 O LYS A 503 44.388 −34.969 −4.896 1.00 24.15 A O ATOM 7805 N GLU A 504 43.937 −33.301 −3.477 1.00 28.57 A N ATOM 7806 CA GLU A 504 43.681 −32.298 −4.520 1.00 28.52 A C ATOM 7808 CB GLU A 504 43.343 −30.946 −3.865 1.00 30.61 A C ATOM 7811 CG GLU A 504 42.958 −29.790 −4.821 1.00 38.94 A C ATOM 7814 CD GLU A 504 41.566 −29.921 −5.427 1.00 46.58 A C ATOM 7815 OE1 GLU A 504 41.310 −29.262 −6.453 1.00 52.18 A O ATOM 7816 OE2 GLU A 504 40.723 −30.683 −4.896 1.00 53.41 A O ATOM 7817 C GLU A 504 44.920 −32.185 −5.412 1.00 27.76 A C ATOM 7818 O GLU A 504 44.814 −32.059 −6.628 1.00 26.82 A O ATOM 7820 N LYS A 505 46.101 −32.268 −4.805 1.00 25.80 A N ATOM 7821 CA LYS A 505 47.338 −32.166 −5.559 1.00 26.51 A C ATOM 7823 CB LYS A 505 48.533 −32.046 −4.617 1.00 23.37 A C ATOM 7826 CG LYS A 505 49.916 −32.048 −5.295 1.00 23.18 A C ATOM 7829 CD LYS A 505 50.165 −30.869 −6.209 1.00 27.18 A C ATOM 7832 CE LYS A 505 51.471 −31.033 −7.011 1.00 21.66 A C ATOM 7835 NZ LYS A 505 52.684 −30.936 −6.205 1.00 31.62 A N ATOM 7839 C LYS A 505 47.531 −33.360 −6.491 1.00 28.51 A C ATOM 7840 O LYS A 505 48.058 −33.230 −7.598 1.00 28.28 A O ATOM 7842 N LEU A 506 47.137 −34.520 −6.011 1.00 31.86 A N ATOM 7843 CA LEU A 506 47.448 −35.765 −6.663 1.00 36.04 A C ATOM 7845 CB LEU A 506 47.288 −36.918 −5.682 1.00 37.63 A C ATOM 7848 CG LEU A 506 48.038 −38.207 −5.980 1.00 42.29 A C ATOM 7850 CD1 LEU A 506 49.507 −37.926 −6.154 1.00 35.85 A C ATOM 7854 CD2 LEU A 506 47.800 −39.204 −4.820 1.00 46.05 A C ATOM 7858 C LEU A 506 46.558 −35.972 −7.872 1.00 37.67 A C ATOM 7859 O LEU A 506 47.003 −36.495 −8.875 1.00 38.71 A O ATOM 7861 N GLY A 507 45.309 −35.552 −7.797 1.00 39.52 A N ATOM 7862 CA GLY A 507 44.443 −35.753 −8.922 1.00 43.92 A C ATOM 7865 C GLY A 507 43.260 −34.842 −8.940 1.00 46.84 A C ATOM 7866 O GLY A 507 42.912 −34.221 −7.932 1.00 49.96 A O ATOM 7868 N GLY A 508 42.676 −34.743 −10.122 1.00 49.06 A N ATOM 7869 CA GLY A 508 41.363 −34.150 −10.302 1.00 50.99 A C ATOM 7872 C GLY A 508 41.194 −32.736 −9.777 1.00 50.71 A C ATOM 7873 O GLY A 508 40.122 −32.409 −9.241 1.00 52.36 A O ATOM 7875 N SER A 509 42.203 −31.880 −9.918 1.00 47.13 A N ATOM 7876 CA SER A 509 41.952 −30.484 −9.528 1.00 47.06 A C ATOM 7878 CB SER A 509 43.191 −29.736 −8.981 1.00 45.68 A C ATOM 7881 OG SER A 509 42.806 −28.477 −8.381 1.00 42.36 A O ATOM 7883 C SER A 509 41.382 −29.749 −10.715 1.00 44.82 A C ATOM 7884 O SER A 509 41.689 −30.070 −11.852 1.00 42.86 A O ATOM 7886 N LEU A 510 40.554 −28.756 −10.416 1.00 45.06 A N ATOM 7887 CA LEU A 510 40.113 −27.777 −11.399 1.00 45.40 A C ATOM 7889 CB LEU A 510 38.958 −26.930 −10.832 1.00 47.41 A C ATOM 7892 CG LEU A 510 37.786 −27.690 −10.165 1.00 55.26 A C ATOM 7894 CD1 LEU A 510 36.624 −26.741 −9.788 1.00 57.58 A C ATOM 7898 CD2 LEU A 510 37.270 −28.882 −11.042 1.00 61.12 A C ATOM 7902 C LEU A 510 41.286 −26.872 −11.801 1.00 42.51 A C ATOM 7903 O LEU A 510 41.294 −26.326 −12.901 1.00 44.42 A O ATOM 7905 N PHE A 511 42.267 −26.730 −10.908 1.00 37.23 A N ATOM 7906 CA PHE A 511 43.472 −25.953 −11.166 1.00 34.84 A C ATOM 7908 CB PHE A 511 43.886 −25.210 −9.902 1.00 34.34 A C ATOM 7911 CG PHE A 511 42.953 −24.144 −9.522 1.00 28.92 A C ATOM 7912 CD1 PHE A 511 43.120 −22.857 −10.008 1.00 29.05 A C ATOM 7914 CE1 PHE A 511 42.239 −21.868 −9.667 1.00 31.91 A C ATOM 7916 CZ PHE A 511 41.166 −22.149 −8.835 1.00 34.31 A C ATOM 7918 CE2 PHE A 511 40.987 −23.436 −8.353 1.00 31.94 A C ATOM 7920 CD2 PHE A 511 41.879 −24.420 −8.705 1.00 28.15 A C ATOM 7922 C PHE A 511 44.646 −26.806 −11.627 1.00 33.67 A C ATOM 7923 O PHE A 511 44.729 −27.979 −11.330 1.00 32.95 A O ATOM 7925 N ALA A 512 45.581 −26.186 −12.334 1.00 35.25 A N ATOM 7926 CA ALA A 512 46.800 −26.873 −12.750 1.00 35.70 A C ATOM 7928 CB ALA A 512 47.539 −26.051 −13.813 1.00 34.66 A C ATOM 7932 C ALA A 512 47.707 −27.148 −11.529 1.00 36.10 A C ATOM 7933 O ALA A 512 47.699 −26.406 −10.547 1.00 36.63 A O ATOM 7935 N LYS A 513 48.475 −28.225 −11.603 1.00 36.02 A N ATOM 7936 CA LYS A 513 49.284 −28.673 −10.484 1.00 37.34 A C ATOM 7938 CB LYS A 513 50.063 −29.942 −10.849 1.00 37.46 A C ATOM 7941 CG LYS A 513 49.162 −31.182 −10.883 1.00 43.80 A C ATOM 7944 CD LYS A 513 49.963 −32.482 −10.925 1.00 50.12 A C ATOM 7947 CE LYS A 513 49.023 −33.696 −10.922 1.00 56.16 A C ATOM 7950 NZ LYS A 513 49.717 −34.969 −10.585 1.00 55.05 A N ATOM 7954 C LYS A 513 50.214 −27.622 −9.884 1.00 35.55 A C ATOM 7955 O LYS A 513 50.337 −27.571 −8.679 1.00 34.97 A O ATOM 7957 N PRO A 514 50.850 −26.775 −10.715 1.00 33.86 A N ATOM 7958 CA PRO A 514 51.776 −25.809 −10.137 1.00 30.23 A C ATOM 7960 CB PRO A 514 52.402 −25.116 −11.359 1.00 30.51 A C ATOM 7963 CG PRO A 514 52.125 −26.036 −12.529 1.00 34.84 A C ATOM 7966 CD PRO A 514 50.855 −26.753 −12.197 1.00 35.73 A C ATOM 7969 C PRO A 514 51.082 −24.796 −9.233 1.00 27.77 A C ATOM 7970 O PRO A 514 51.627 −24.406 −8.205 1.00 30.05 A O ATOM 7971 N PHE A 515 49.886 −24.373 −9.587 1.00 25.77 A N ATOM 7972 CA PHE A 515 49.195 −23.428 −8.732 1.00 24.83 A C ATOM 7974 CB PHE A 515 48.074 −22.699 −9.462 1.00 23.92 A C ATOM 7977 CG PHE A 515 47.262 −21.818 −8.557 1.00 26.15 A C ATOM 7978 CD1 PHE A 515 47.779 −20.626 −8.087 1.00 25.26 A C ATOM 7980 CE1 PHE A 515 47.041 −19.832 −7.203 1.00 25.88 A C ATOM 7982 CZ PHE A 515 45.780 −20.227 −6.804 1.00 22.17 A C ATOM 7984 CE2 PHE A 515 45.266 −21.432 −7.253 1.00 23.27 A C ATOM 7986 CD2 PHE A 515 46.011 −22.225 −8.108 1.00 26.63 A C ATOM 7988 C PHE A 515 48.675 −24.143 −7.460 1.00 24.34 A C ATOM 7989 O PHE A 515 48.794 −23.599 −6.371 1.00 23.33 A O ATOM 7991 N VAL A 516 48.156 −25.369 −7.588 1.00 22.98 A N ATOM 7992 CA VAL A 516 47.815 −26.159 −6.401 1.00 22.66 A C ATOM 7994 CB VAL A 516 47.387 −27.605 −6.706 1.00 24.87 A C ATOM 7996 CG1 VAL A 516 46.149 −27.671 −7.666 1.00 22.01 A C ATOM 8000 CG2 VAL A 516 47.109 −28.387 −5.377 1.00 17.25 A C ATOM 8004 C VAL A 516 49.022 −26.187 −5.432 1.00 22.26 A C ATOM 8005 O VAL A 516 48.861 −25.964 −4.228 1.00 21.22 A O ATOM 8007 N GLU A 517 50.213 −26.411 −5.976 1.00 21.70 A N ATOM 8008 CA GLU A 517 51.456 −26.510 −5.188 1.00 22.29 A C ATOM 8010 CB GLU A 517 52.584 −27.047 −6.072 1.00 22.50 A C ATOM 8013 CG GLU A 517 53.939 −27.283 −5.376 1.00 19.35 A C ATOM 8016 CD GLU A 517 53.941 −28.451 −4.347 1.00 27.61 A C ATOM 8017 OE1 GLU A 517 52.962 −29.218 −4.228 1.00 23.47 A O ATOM 8018 OE2 GLU A 517 54.940 −28.605 −3.631 1.00 30.16 A O ATOM 8019 C GLU A 517 51.847 −25.157 −4.576 1.00 22.35 A C ATOM 8020 O GLU A 517 52.253 −25.096 −3.404 1.00 26.83 A O ATOM 8022 N THR A 518 51.709 −24.082 −5.354 1.00 21.58 A N ATOM 8023 CA THR A 518 51.902 −22.731 −4.836 1.00 24.40 A C ATOM 8025 CB THR A 518 51.689 −21.634 −5.925 1.00 26.67 A C ATOM 8027 OG1 THR A 518 52.642 −21.808 −6.973 1.00 23.81 A O ATOM 8029 CG2 THR A 518 51.876 −20.228 −5.351 1.00 24.26 A C ATOM 8033 C THR A 518 50.969 −22.518 −3.644 1.00 25.98 A C ATOM 8034 O THR A 518 51.400 −22.003 −2.596 1.00 25.54 A O ATOM 8036 N ALA A 519 49.717 −22.968 −3.774 1.00 23.55 A N ATOM 8037 CA ALA A 519 48.772 −22.859 −2.676 1.00 23.19 A C ATOM 8039 CB ALA A 519 47.375 −23.219 −3.096 1.00 20.70 A C ATOM 8043 C ALA A 519 49.182 −23.644 −1.436 1.00 23.29 A C ATOM 8044 O ALA A 519 49.096 −23.125 −0.286 1.00 24.26 A O ATOM 8046 N ILE A 520 49.673 −24.853 −1.639 1.00 21.17 A N ATOM 8047 CA ILE A 520 50.097 −25.677 −0.500 1.00 19.87 A C ATOM 8049 CB ILE A 520 50.425 −27.126 −0.957 1.00 20.77 A C ATOM 8051 CG1 ILE A 520 49.146 −27.857 −1.421 1.00 20.74 A C ATOM 8054 CD1 ILE A 520 49.421 −29.223 −2.184 1.00 19.45 A C ATOM 8058 CG2 ILE A 520 51.083 −27.909 0.152 1.00 16.11 A C ATOM 8062 C ILE A 520 51.288 −25.003 0.202 1.00 20.17 A C ATOM 8063 O ILE A 520 51.384 −25.018 1.437 1.00 19.37 A O ATOM 8065 N ASN A 521 52.166 −24.366 −0.574 1.00 21.54 A N ATOM 8066 CA ASN A 521 53.299 −23.620 0.014 1.00 20.54 A C ATOM 8068 CB ASN A 521 54.188 −22.992 −1.066 1.00 21.56 A C ATOM 8071 CG ASN A 521 54.966 −24.024 −1.867 1.00 24.44 A C ATOM 8072 OD1 ASN A 521 55.198 −25.124 −1.399 1.00 19.38 A O ATOM 8073 ND2 ASN A 521 55.365 −23.666 −3.084 1.00 18.91 A N ATOM 8076 C ASN A 521 52.892 −22.559 1.017 1.00 19.40 A C ATOM 8077 O ASN A 521 53.621 −22.274 1.946 1.00 20.79 A O ATOM 8079 N LEU A 522 51.724 −21.961 0.870 1.00 22.97 A N ATOM 8080 CA LEU A 522 51.287 −21.020 1.894 1.00 22.18 A C ATOM 8082 CB LEU A 522 49.999 −20.375 1.480 1.00 21.54 A C ATOM 8085 CG LEU A 522 49.371 −19.451 2.528 1.00 28.84 A C ATOM 8087 CD1 LEU A 522 49.451 −18.040 2.067 1.00 28.12 A C ATOM 8091 CD2 LEU A 522 47.923 −19.860 2.764 1.00 22.93 A C ATOM 8095 C LEU A 522 51.128 −21.739 3.258 1.00 23.98 A C ATOM 8096 O LEU A 522 51.440 −21.191 4.335 1.00 27.60 A O ATOM 8098 N ALA A 523 50.655 −22.966 3.219 1.00 20.93 A N ATOM 8099 CA ALA A 523 50.483 −23.745 4.435 1.00 20.65 A C ATOM 8101 CB ALA A 523 49.688 −25.053 4.123 1.00 18.52 A C ATOM 8105 C ALA A 523 51.858 −24.069 5.025 1.00 19.62 A C ATOM 8106 O ALA A 523 52.066 −23.988 6.225 1.00 19.29 A O ATOM 8108 N ARG A 524 52.790 −24.453 4.158 1.00 21.30 A N ATOM 8109 CA ARG A 524 54.160 −24.730 4.566 1.00 19.62 A C ATOM 8111 CB ARG A 524 54.994 −25.155 3.355 1.00 19.24 A C ATOM 8114 CG ARG A 524 54.604 −26.493 2.752 1.00 20.08 A C ATOM 8117 CD ARG A 524 55.572 −26.973 1.663 1.00 16.22 A C ATOM 8120 NE ARG A 524 55.254 −28.341 1.267 1.00 17.63 A N ATOM 8122 CZ ARG A 524 54.851 −28.736 0.065 1.00 22.37 A C ATOM 8123 NH1 ARG A 524 54.705 −27.877 −0.917 1.00 22.88 A N ATOM 8126 NH2 ARG A 524 54.577 −30.020 −0.153 1.00 22.48 A N ATOM 8129 C ARG A 524 54.783 −23.497 5.211 1.00 18.86 A C ATOM 8130 O ARG A 524 55.416 −23.587 6.243 1.00 20.03 A O ATOM 8132 N GLN A 525 54.627 −22.344 4.577 1.00 21.45 A N ATOM 8133 CA GLN A 525 55.227 −21.127 5.095 1.00 23.44 A C ATOM 8135 CB GLN A 525 55.050 −19.940 4.126 1.00 24.10 A C ATOM 8138 CG GLN A 525 55.702 −18.631 4.655 1.00 27.82 A C ATOM 8141 CD GLN A 525 57.200 −18.783 4.854 1.00 31.75 A C ATOM 8142 OE1 GLN A 525 57.858 −19.483 4.107 1.00 35.59 A O ATOM 8143 NE2 GLN A 525 57.741 −18.116 5.854 1.00 35.48 A N ATOM 8146 C GLN A 525 54.618 −20.823 6.442 1.00 21.93 A C ATOM 8147 O GLN A 525 55.301 −20.367 7.349 1.00 24.82 A O ATOM 8149 N SER A 526 53.335 −21.125 6.588 1.00 23.48 A N ATOM 8150 CA SER A 526 52.645 −20.951 7.865 1.00 21.99 A C ATOM 8152 CB SER A 526 51.157 −21.240 7.721 1.00 21.77 A C ATOM 8155 OG SER A 526 50.545 −20.385 6.756 1.00 27.32 A O ATOM 8157 C SER A 526 53.245 −21.829 8.945 1.00 24.68 A C ATOM 8158 O SER A 526 53.518 −21.362 10.061 1.00 24.00 A O ATOM 8160 N HIS A 527 53.480 −23.096 8.630 1.00 24.99 A N ATOM 8161 CA HIS A 527 54.171 −23.962 9.610 1.00 28.16 A C ATOM 8163 CB HIS A 527 54.357 −25.381 9.073 1.00 29.27 A C ATOM 8166 CG HIS A 527 53.101 −26.172 9.090 1.00 25.87 A C ATOM 8167 ND1 HIS A 527 52.548 −26.642 10.258 1.00 26.45 A N ATOM 8169 CE1 HIS A 527 51.424 −27.278 9.982 1.00 25.98 A C ATOM 8171 NE2 HIS A 527 51.211 −27.201 8.681 1.00 24.15 A N ATOM 8173 CD2 HIS A 527 52.241 −26.501 8.102 1.00 26.74 A C ATOM 8175 C HIS A 527 55.523 −23.428 10.010 1.00 28.59 A C ATOM 8176 O HIS A 527 55.911 −23.545 11.155 1.00 29.28 A O ATOM 8178 N CYS A 528 56.233 −22.863 9.042 1.00 29.41 A N ATOM 8179 CA CYS A 528 57.620 −22.452 9.236 1.00 32.72 A C ATOM 8181 CB CYS A 528 58.325 −22.320 7.884 1.00 30.69 A C ATOM 8184 SG CYS A 528 58.709 −23.947 7.199 1.00 30.00 A S ATOM 8186 C CYS A 528 57.731 −21.150 10.027 1.00 35.27 A C ATOM 8187 O CYS A 528 58.642 −20.983 10.799 1.00 35.65 A O ATOM 8189 N THR A 529 56.784 −20.249 9.814 1.00 39.06 A N ATOM 8190 CA THR A 529 56.751 −18.951 10.470 1.00 40.10 A C ATOM 8192 CB THR A 529 55.848 −18.006 9.689 1.00 40.17 A C ATOM 8194 OG1 THR A 529 56.529 −17.624 8.491 1.00 38.25 A O ATOM 8196 CG2 THR A 529 55.488 −16.770 10.521 1.00 39.82 A C ATOM 8200 C THR A 529 56.265 −19.016 11.911 1.00 42.32 A C ATOM 8201 O THR A 529 56.803 −18.308 12.775 1.00 43.34 A O ATOM 8203 N TYR A 530 55.263 −19.854 12.173 1.00 44.35 A N ATOM 8204 CA TYR A 530 54.693 −19.966 13.505 1.00 46.00 A C ATOM 8206 CB TYR A 530 53.166 −20.032 13.439 1.00 44.27 A C ATOM 8209 CG TYR A 530 52.609 −18.762 12.860 1.00 37.30 A C ATOM 8210 CD1 TYR A 530 52.537 −17.608 13.623 1.00 41.32 A C ATOM 8212 CE1 TYR A 530 52.068 −16.421 13.084 1.00 36.85 A C ATOM 8214 CZ TYR A 530 51.680 −16.379 11.772 1.00 34.37 A C ATOM 8215 OH TYR A 530 51.224 −15.203 11.239 1.00 42.34 A O ATOM 8217 CE2 TYR A 530 51.754 −17.510 10.987 1.00 37.02 A C ATOM 8219 CD2 TYR A 530 52.225 −18.687 11.535 1.00 33.51 A C ATOM 8221 C TYR A 530 55.343 −21.106 14.288 1.00 51.39 A C ATOM 8222 O TYR A 530 54.775 −22.175 14.481 1.00 52.31 A O ATOM 8224 N HIS A 531 56.561 −20.811 14.740 1.00 58.00 A N ATOM 8225 CA HIS A 531 57.399 −21.680 15.572 1.00 61.94 A C ATOM 8227 CB HIS A 531 58.753 −21.900 14.875 1.00 62.85 A C ATOM 8230 CG HIS A 531 59.575 −20.646 14.738 1.00 65.82 A C ATOM 8231 ND1 HIS A 531 59.608 −19.895 13.579 1.00 70.80 A N ATOM 8233 CE1 HIS A 531 60.404 −18.852 13.752 1.00 66.74 A C ATOM 8235 NE2 HIS A 531 60.883 −18.894 14.982 1.00 63.48 A N ATOM 8237 CD2 HIS A 531 60.381 −20.004 15.620 1.00 65.00 A C ATOM 8239 C HIS A 531 57.655 −20.986 16.920 1.00 64.85 A C ATOM 8240 O HIS A 531 57.504 −19.758 17.030 1.00 64.46 A O ATOM 8242 N ASN A 532 58.067 −21.766 17.926 1.00 67.27 A N ATOM 8243 CA ASN A 532 58.496 −21.224 19.224 1.00 68.94 A C ATOM 8245 CB ASN A 532 57.603 −21.755 20.366 1.00 70.24 A C ATOM 8248 CG ASN A 532 56.240 −21.039 20.445 1.00 75.92 A C ATOM 8249 OD1 ASN A 532 55.500 −20.950 19.452 1.00 78.73 A O ATOM 8250 ND2 ASN A 532 55.906 −20.536 21.638 1.00 74.91 A N ATOM 8253 C ASN A 532 59.981 −21.534 19.481 1.00 68.89 A C ATOM 8254 O ASN A 532 60.352 −22.156 20.484 1.00 68.53 A O ATOM 8256 N THR A 537 67.332 −21.795 21.607 1.00 92.68 A N ATOM 8257 CA THR A 537 66.924 −20.612 20.853 1.00 93.30 A C ATOM 8259 CB THR A 537 66.958 −20.873 19.320 1.00 93.55 A C ATOM 8261 OG1 THR A 537 68.054 −21.736 18.994 1.00 94.33 A O ATOM 8263 CG2 THR A 537 67.102 −19.564 18.539 1.00 93.26 A C ATOM 8267 C THR A 537 65.513 −20.160 21.260 1.00 93.42 A C ATOM 8268 O THR A 537 64.724 −20.952 21.790 1.00 93.83 A O ATOM 8270 N SER A 538 65.215 −18.883 21.009 1.00 92.90 A N ATOM 8271 CA SER A 538 63.908 −18.278 21.299 1.00 92.33 A C ATOM 8273 CB SER A 538 64.113 −17.011 22.137 1.00 92.35 A C ATOM 8276 OG SER A 538 64.875 −16.046 21.429 1.00 90.48 A O ATOM 8278 C SER A 538 63.159 −17.940 19.991 1.00 91.91 A C ATOM 8279 O SER A 538 63.751 −18.023 18.918 1.00 90.87 A O ATOM 8281 N PRO A 539 61.852 −17.583 20.077 1.00 92.14 A N ATOM 8282 CA PRO A 539 61.015 −17.108 18.952 1.00 91.90 A C ATOM 8284 CB PRO A 539 59.778 −16.550 19.670 1.00 92.24 A C ATOM 8287 CG PRO A 539 59.602 −17.482 20.811 1.00 93.29 A C ATOM 8290 CD PRO A 539 61.005 −17.907 21.244 1.00 92.54 A C ATOM 8293 C PRO A 539 61.663 −16.079 17.996 1.00 90.64 A C ATOM 8294 O PRO A 539 62.570 −16.453 17.254 1.00 90.97 A O ATOM 8295 N ASP A 540 61.200 −14.823 17.973 1.00 88.91 A N ATOM 8296 CA ASP A 540 61.764 −13.832 17.045 1.00 87.34 A C ATOM 8298 CB ASP A 540 60.995 −12.501 17.090 1.00 88.16 A C ATOM 8301 CG ASP A 540 61.064 −11.734 15.767 1.00 91.26 A C ATOM 8302 OD1 ASP A 540 62.082 −11.847 15.046 1.00 92.68 A O ATOM 8303 OD2 ASP A 540 60.095 −11.012 15.445 1.00 92.20 A O ATOM 8304 C ASP A 540 63.249 −13.623 17.357 1.00 83.97 A C ATOM 8305 O ASP A 540 63.608 −12.904 18.291 1.00 84.17 A O ATOM 8307 N GLU A 541 64.085 −14.261 16.542 1.00 80.01 A N ATOM 8308 CA GLU A 541 65.522 −14.464 16.780 1.00 77.67 A C ATOM 8310 CB GLU A 541 65.870 −14.669 18.260 1.00 78.10 A C ATOM 8313 CG GLU A 541 67.352 −14.486 18.565 1.00 81.78 A C ATOM 8316 CD GLU A 541 67.610 −13.838 19.922 1.00 88.80 A C ATOM 8317 OE1 GLU A 541 67.125 −12.702 20.144 1.00 90.81 A O ATOM 8318 OE2 GLU A 541 68.306 −14.453 20.761 1.00 88.82 A O ATOM 8319 C GLU A 541 65.937 −15.699 15.973 1.00 73.57 A C ATOM 8320 O GLU A 541 66.977 −15.711 15.311 1.00 73.68 A O ATOM 8322 N LEU A 542 65.116 −16.743 16.054 1.00 68.45 A N ATOM 8323 CA LEU A 542 65.113 −17.805 15.051 1.00 64.32 A C ATOM 8325 CB LEU A 542 64.264 −18.994 15.512 1.00 64.16 A C ATOM 8328 CG LEU A 542 64.082 −20.157 14.527 1.00 66.34 A C ATOM 8330 CD1 LEU A 542 63.430 −21.367 15.221 1.00 64.49 A C ATOM 8334 CD2 LEU A 542 65.418 −20.547 13.870 1.00 67.67 A C ATOM 8338 C LEU A 542 64.583 −17.236 13.731 1.00 59.26 A C ATOM 8339 O LEU A 542 65.135 −17.512 12.679 1.00 56.08 A O ATOM 8341 N THR A 543 63.525 −16.431 13.807 1.00 55.75 A N ATOM 8342 CA THR A 543 63.001 −15.694 12.652 1.00 53.99 A C ATOM 8344 CB THR A 543 61.827 −14.798 13.080 1.00 52.82 A C ATOM 8346 OG1 THR A 543 60.796 −15.613 13.647 1.00 55.45 A O ATOM 8348 CG2 THR A 543 61.266 −13.999 11.910 1.00 47.21 A C ATOM 8352 C THR A 543 64.055 −14.811 11.984 1.00 53.90 A C ATOM 8353 O THR A 543 64.132 −14.738 10.754 1.00 53.78 A O ATOM 8355 N ARG A 544 64.861 −14.141 12.807 1.00 53.78 A N ATOM 8356 CA ARG A 544 65.880 −13.214 12.320 1.00 53.00 A C ATOM 8358 CB ARG A 544 66.482 −12.402 13.487 1.00 54.30 A C ATOM 8361 CG ARG A 544 67.763 −11.600 13.148 1.00 58.88 A C ATOM 8364 CD ARG A 544 68.416 −10.977 14.395 1.00 68.64 A C ATOM 8367 NE ARG A 544 68.769 −11.968 15.421 1.00 75.29 A N ATOM 8369 CZ ARG A 544 69.815 −12.799 15.370 1.00 78.84 A C ATOM 8370 NH1 ARG A 544 70.654 −12.793 14.334 1.00 78.60 A N ATOM 8373 NH2 ARG A 544 70.023 −13.656 16.367 1.00 78.30 A N ATOM 8376 C ARG A 544 66.977 −13.965 11.591 1.00 50.00 A C ATOM 8377 O ARG A 544 67.503 −13.474 10.602 1.00 49.41 A O ATOM 8379 N LYS A 545 67.342 −15.131 12.113 1.00 47.99 A N ATOM 8380 CA LYS A 545 68.378 −15.955 11.497 1.00 48.74 A C ATOM 8382 CB LYS A 545 68.824 −17.088 12.442 1.00 50.27 A C ATOM 8385 CG LYS A 545 69.814 −16.611 13.534 1.00 59.32 A C ATOM 8388 CD LYS A 545 70.549 −17.761 14.252 1.00 64.78 A C ATOM 8391 CE LYS A 545 71.708 −17.208 15.089 1.00 70.21 A C ATOM 8394 NZ LYS A 545 72.591 −18.251 15.680 1.00 71.30 A N ATOM 8398 C LYS A 545 67.892 −16.520 10.167 1.00 44.99 A C ATOM 8399 O LYS A 545 68.642 −16.585 9.194 1.00 42.74 A O ATOM 8401 N ARG A 546 66.624 −16.911 10.141 1.00 43.75 A N ATOM 8402 CA ARG A 546 66.006 −17.452 8.934 1.00 42.43 A C ATOM 8404 CB ARG A 546 64.624 −18.006 9.244 1.00 41.43 A C ATOM 8407 CG ARG A 546 64.725 −19.301 10.007 1.00 34.91 A C ATOM 8410 CD ARG A 546 63.396 −19.926 10.297 1.00 35.83 A C ATOM 8413 NE ARG A 546 63.616 −21.251 10.863 1.00 35.94 A N ATOM 8415 CZ ARG A 546 62.659 −22.099 11.220 1.00 36.20 A C ATOM 8416 NH1 ARG A 546 61.380 −21.769 11.093 1.00 37.38 A N ATOM 8419 NH2 ARG A 546 62.992 −23.276 11.743 1.00 39.23 A N ATOM 8422 C ARG A 546 65.963 −16.413 7.826 1.00 42.22 A C ATOM 8423 O ARG A 546 66.372 −16.706 6.704 1.00 42.78 A O ATOM 8425 N VAL A 547 65.537 −15.192 8.153 1.00 40.65 A N ATOM 8426 CA VAL A 547 65.599 −14.085 7.193 1.00 40.43 A C ATOM 8428 CB VAL A 547 65.055 −12.771 7.810 1.00 41.44 A C ATOM 8430 CG1 VAL A 547 65.454 −11.568 6.974 1.00 43.77 A C ATOM 8434 CG2 VAL A 547 63.543 −12.847 7.984 1.00 37.89 A C ATOM 8438 C VAL A 547 67.028 −13.846 6.715 1.00 40.76 A C ATOM 8439 O VAL A 547 67.269 −13.551 5.547 1.00 41.64 A O ATOM 8441 N LEU A 548 67.978 −13.952 7.632 1.00 39.02 A N ATOM 8442 CA LEU A 548 69.369 −13.763 7.283 1.00 37.94 A C ATOM 8444 CB LEU A 548 70.239 −13.775 8.544 1.00 38.42 A C ATOM 8447 CG LEU A 548 71.184 −12.599 8.823 1.00 45.83 A C ATOM 8449 CD1 LEU A 548 70.487 −11.217 8.801 1.00 41.58 A C ATOM 8453 CD2 LEU A 548 71.866 −12.861 10.179 1.00 43.53 A C ATOM 8457 C LEU A 548 69.805 −14.866 6.305 1.00 36.31 A C ATOM 8458 O LEU A 548 70.419 −14.589 5.281 1.00 37.41 A O ATOM 8460 N SER A 549 69.471 −16.115 6.607 1.00 33.80 A N ATOM 8461 CA SER A 549 69.995 −17.230 5.830 1.00 32.40 A C ATOM 8463 CB SER A 549 69.914 −18.526 6.640 1.00 32.69 A C ATOM 8466 OG SER A 549 68.573 −18.865 6.912 1.00 33.82 A O ATOM 8468 C SER A 549 69.258 −17.374 4.497 1.00 29.96 A C ATOM 8469 O SER A 549 69.816 −17.884 3.525 1.00 28.51 A O ATOM 8471 N VAL A 550 68.017 −16.896 4.444 1.00 28.34 A N ATOM 8472 CA VAL A 550 67.218 −16.982 3.232 1.00 26.12 A C ATOM 8474 CB VAL A 550 65.754 −17.231 3.551 1.00 27.43 A C ATOM 8476 CG1 VAL A 550 64.912 −17.149 2.274 1.00 22.74 A C ATOM 8480 CG2 VAL A 550 65.603 −18.589 4.190 1.00 20.03 A C ATOM 8484 C VAL A 550 67.352 −15.777 2.320 1.00 27.26 A C ATOM 8485 O VAL A 550 67.466 −15.933 1.101 1.00 26.44 A O ATOM 8487 N ILE A 551 67.367 −14.575 2.877 1.00 28.59 A N ATOM 8488 CA ILE A 551 67.457 −13.380 2.037 1.00 30.46 A C ATOM 8490 CB ILE A 551 66.537 −12.274 2.537 1.00 31.18 A C ATOM 8492 CG1 ILE A 551 65.093 −12.747 2.553 1.00 29.53 A C ATOM 8495 CD1 ILE A 551 64.570 −13.145 1.191 1.00 40.54 A C ATOM 8499 CG2 ILE A 551 66.697 −11.023 1.653 1.00 29.98 A C ATOM 8503 C ILE A 551 68.841 −12.746 1.941 1.00 31.12 A C ATOM 8504 O ILE A 551 69.329 −12.460 0.843 1.00 30.57 A O ATOM 8506 N THR A 552 69.453 −12.486 3.090 1.00 33.43 A N ATOM 8507 CA THR A 552 70.551 −11.541 3.150 1.00 35.23 A C ATOM 8509 CB THR A 552 70.422 −10.661 4.419 1.00 38.85 A C ATOM 8511 OG1 THR A 552 70.734 −11.431 5.583 1.00 49.74 A O ATOM 8513 CG2 THR A 552 69.002 −10.115 4.567 1.00 34.09 A C ATOM 8517 C THR A 552 71.979 −12.148 3.020 1.00 35.34 A C ATOM 8518 O THR A 552 72.805 −11.623 2.259 1.00 34.57 A O ATOM 8520 N GLU A 553 72.273 −13.222 3.752 1.00 35.04 A N ATOM 8521 CA GLU A 553 73.628 −13.801 3.777 1.00 36.99 A C ATOM 8523 CB GLU A 553 74.020 −14.209 5.200 1.00 38.28 A C ATOM 8526 CG GLU A 553 74.412 −13.034 6.080 1.00 46.45 A C ATOM 8529 CD GLU A 553 75.002 −13.456 7.418 1.00 57.04 A C ATOM 8530 OE1 GLU A 553 75.499 −12.564 8.142 1.00 60.01 A O ATOM 8531 OE2 GLU A 553 74.972 −14.667 7.750 1.00 60.27 A O ATOM 8532 C GLU A 553 73.756 −15.027 2.879 1.00 35.15 A C ATOM 8533 O GLU A 553 73.085 −16.016 3.094 1.00 33.64 A O ATOM 8535 N PRO A 554 74.649 −14.979 1.890 1.00 35.47 A N ATOM 8536 CA PRO A 554 74.878 −16.177 1.087 1.00 33.93 A C ATOM 8538 CB PRO A 554 75.924 −15.722 0.056 1.00 35.05 A C ATOM 8541 CG PRO A 554 75.825 −14.234 0.044 1.00 35.89 A C ATOM 8544 CD PRO A 554 75.486 −13.854 1.441 1.00 36.23 A C ATOM 8547 C PRO A 554 75.426 −17.330 1.903 1.00 31.36 A C ATOM 8548 O PRO A 554 75.880 −17.153 3.018 1.00 31.42 A O ATOM 8549 N ILE A 555 75.349 −18.518 1.342 1.00 30.82 A N ATOM 8550 CA ILE A 555 75.946 −19.684 1.957 1.00 31.22 A C ATOM 8552 CB ILE A 555 75.349 −20.985 1.366 1.00 30.17 A C ATOM 8554 CG1 ILE A 555 73.862 −21.095 1.715 1.00 30.75 A C ATOM 8557 CD1 ILE A 555 73.166 −22.359 1.159 1.00 26.65 A C ATOM 8561 CG2 ILE A 555 76.096 −22.190 1.874 1.00 29.43 A C ATOM 8565 C ILE A 555 77.455 −19.589 1.694 1.00 30.28 A C ATOM 8566 O ILE A 555 77.853 −19.201 0.607 1.00 27.19 A O ATOM 8568 N LEU A 556 78.273 −19.924 2.693 1.00 31.81 A N ATOM 8569 CA LEU A 556 79.736 −19.843 2.571 1.00 33.19 A C ATOM 8571 CB LEU A 556 80.432 −20.311 3.857 1.00 33.04 A C ATOM 8574 CG LEU A 556 80.327 −19.370 5.071 1.00 40.15 A C ATOM 8576 CD1 LEU A 556 80.560 −20.126 6.367 1.00 44.82 A C ATOM 8580 CD2 LEU A 556 81.297 −18.182 4.960 1.00 40.79 A C ATOM 8584 C LEU A 556 80.195 −20.687 1.391 1.00 33.20 A C ATOM 8585 O LEU A 556 79.754 −21.814 1.234 1.00 34.64 A O ATOM 8587 N PRO A 557 81.093 −20.150 0.560 1.00 34.80 A N ATOM 8588 CA PRO A 557 81.389 −20.817 −0.707 1.00 34.59 A C ATOM 8590 CB PRO A 557 82.379 −19.878 −1.402 1.00 35.42 A C ATOM 8593 CG PRO A 557 82.956 −19.016 −0.316 1.00 37.04 A C ATOM 8596 CD PRO A 557 82.005 −19.023 0.846 1.00 35.67 A C ATOM 8599 C PRO A 557 82.003 −22.187 −0.532 1.00 34.31 A C ATOM 8600 O PRO A 557 82.598 −22.485 0.497 1.00 34.81 A O ATOM 8601 N PHE A 558 81.824 −23.015 −1.548 1.00 34.16 A N ATOM 8602 CA PHE A 558 82.422 −24.328 −1.595 1.00 34.90 A C ATOM 8604 CB PHE A 558 82.071 −24.950 −2.929 1.00 32.02 A C ATOM 8607 CG PHE A 558 82.786 −26.220 −3.210 1.00 33.45 A C ATOM 8608 CD1 PHE A 558 83.795 −26.268 −4.157 1.00 35.45 A C ATOM 8610 CE1 PHE A 558 84.443 −27.463 −4.429 1.00 39.71 A C ATOM 8612 CZ PHE A 558 84.082 −28.618 −3.750 1.00 40.59 A C ATOM 8614 CE2 PHE A 558 83.074 −28.575 −2.805 1.00 37.21 A C ATOM 8616 CD2 PHE A 558 82.440 −27.382 −2.536 1.00 34.24 A C ATOM 8618 C PHE A 558 83.950 −24.247 −1.466 1.00 37.69 A C ATOM 8619 O PHE A 558 84.563 −23.354 −2.050 1.00 35.80 A O ATOM 8621 N GLU A 559 84.547 −25.183 −0.726 1.00 42.77 A N ATOM 8622 CA GLU A 559 86.019 −25.260 −0.597 1.00 49.59 A C ATOM 8624 CB GLU A 559 86.454 −25.349 0.882 1.00 50.56 A C ATOM 8627 CG GLU A 559 86.515 −23.989 1.607 1.00 54.49 A C ATOM 8630 CD GLU A 559 87.615 −23.913 2.683 1.00 62.33 A C ATOM 8631 OE1 GLU A 559 88.034 −24.964 3.225 1.00 60.02 A O ATOM 8632 OE2 GLU A 559 88.065 −22.786 2.989 1.00 62.02 A O ATOM 8633 C GLU A 559 86.678 −26.368 −1.464 1.00 52.68 A C ATOM 8634 O GLU A 559 86.943 −26.123 −2.636 1.00 54.35 A O ATOM 8636 N ARG A 560 86.938 −27.551 −0.895 1.00 55.62 A N ATOM 8637 CA ARG A 560 87.722 −28.662 −1.529 1.00 58.23 A C ATOM 8639 CB ARG A 560 88.710 −28.199 −2.636 1.00 59.46 A C ATOM 8642 CG ARG A 560 88.211 −28.475 −4.084 1.00 65.26 A C ATOM 8645 CD ARG A 560 88.672 −27.426 −5.136 1.00 70.99 A C ATOM 8648 NE ARG A 560 87.572 −27.065 −6.051 1.00 76.26 A N ATOM 8650 CZ ARG A 560 87.471 −25.927 −6.754 1.00 78.60 A C ATOM 8651 NH1 ARG A 560 88.419 −24.990 −6.703 1.00 78.10 A N ATOM 8654 NH2 ARG A 560 86.402 −25.724 −7.529 1.00 77.34 A N ATOM 8657 C ARG A 560 88.497 −29.449 −0.470 1.00 57.56 A C ATOM 8658 O ARG A 560 89.485 −28.950 0.077 1.00 57.69 A O ATOM 8660 N ALA B 23 68.865 37.021 10.784 1.00 63.55 B N ATOM 8661 CA ALA B 23 69.934 36.293 10.034 1.00 63.42 B C ATOM 8663 CB ALA B 23 71.193 36.204 10.865 1.00 63.20 B C ATOM 8667 C ALA B 23 69.468 34.898 9.638 1.00 63.10 B C ATOM 8668 O ALA B 23 68.478 34.404 10.177 1.00 63.23 B O ATOM 8672 N ASN B 24 70.182 34.274 8.698 1.00 62.83 B N ATOM 8673 CA ASN B 24 69.852 32.919 8.208 1.00 62.89 B C ATOM 8675 CB ASN B 24 68.986 33.004 6.939 1.00 64.13 B C ATOM 8678 CG ASN B 24 68.555 31.630 6.414 1.00 66.01 B C ATOM 8679 OD1 ASN B 24 67.998 30.809 7.149 1.00 66.06 B O ATOM 8680 ND2 ASN B 24 68.801 31.389 5.132 1.00 66.01 B N ATOM 8683 C ASN B 24 71.083 32.041 7.929 1.00 60.68 B C ATOM 8684 O ASN B 24 71.878 32.334 7.029 1.00 60.33 B O ATOM 8686 N TYR B 25 71.215 30.959 8.699 1.00 58.42 B N ATOM 8687 CA TYR B 25 72.299 29.991 8.529 1.00 56.45 B C ATOM 8689 CB TYR B 25 73.034 29.771 9.854 1.00 54.20 B C ATOM 8692 CG TYR B 25 73.585 31.045 10.447 1.00 45.61 B C ATOM 8693 CD1 TYR B 25 74.573 31.785 9.789 1.00 37.42 B C ATOM 8695 CE1 TYR B 25 75.070 32.965 10.343 1.00 34.67 B C ATOM 8697 CZ TYR B 25 74.575 33.398 11.567 1.00 26.79 B C ATOM 8698 OH TYR B 25 75.031 34.555 12.166 1.00 22.69 B O ATOM 8700 CE2 TYR B 25 73.602 32.674 12.215 1.00 26.03 B C ATOM 8702 CD2 TYR B 25 73.112 31.521 11.660 1.00 34.02 B C ATOM 8704 C TYR B 25 71.835 28.640 7.990 1.00 57.64 B C ATOM 8705 O TYR B 25 72.641 27.717 7.901 1.00 57.97 B O ATOM 8707 N GLU B 26 70.560 28.511 7.620 1.00 59.08 B N ATOM 8708 CA GLU B 26 70.045 27.223 7.118 1.00 60.48 B C ATOM 8710 CB GLU B 26 68.510 27.159 7.198 1.00 61.50 B C ATOM 8713 CG GLU B 26 67.992 27.065 8.651 1.00 68.14 B C ATOM 8716 CD GLU B 26 66.579 26.483 8.775 1.00 76.80 B C ATOM 8717 OE1 GLU B 26 66.038 25.934 7.784 1.00 81.59 B O ATOM 8718 OE2 GLU B 26 66.008 26.568 9.885 1.00 80.08 B O ATOM 8719 C GLU B 26 70.551 26.918 5.694 1.00 58.35 B C ATOM 8720 O GLU B 26 70.748 27.837 4.898 1.00 55.74 B O ATOM 8722 N PRO B 27 70.785 25.623 5.389 1.00 58.14 B N ATOM 8723 CA PRO B 27 71.383 25.254 4.106 1.00 57.29 B C ATOM 8725 CB PRO B 27 71.677 23.759 4.265 1.00 58.74 B C ATOM 8728 CG PRO B 27 70.648 23.277 5.248 1.00 58.92 B C ATOM 8731 CD PRO B 27 70.460 24.434 6.207 1.00 58.03 B C ATOM 8734 C PRO B 27 70.427 25.464 2.951 1.00 56.06 B C ATOM 8735 O PRO B 27 69.206 25.463 3.137 1.00 56.00 B O ATOM 8736 N ASN B 28 70.993 25.657 1.768 1.00 54.96 B N ATOM 8737 CA ASN B 28 70.214 25.706 0.536 1.00 54.67 B C ATOM 8739 CB ASN B 28 70.821 26.721 −0.448 1.00 55.69 B C ATOM 8742 CG ASN B 28 71.032 28.083 0.184 1.00 56.97 B C ATOM 8743 OD1 ASN B 28 70.102 28.660 0.744 1.00 59.86 B O ATOM 8744 ND2 ASN B 28 72.262 28.593 0.118 1.00 57.20 B N ATOM 8747 C ASN B 28 70.152 24.318 −0.095 1.00 52.96 B C ATOM 8748 O ASN B 28 71.036 23.469 0.110 1.00 50.45 B O ATOM 8750 N SER B 29 69.092 24.090 −0.858 1.00 52.74 B N ATOM 8751 CA SER B 29 68.943 22.848 −1.620 1.00 53.12 B C ATOM 8753 CB SER B 29 67.530 22.783 −2.229 1.00 53.87 B C ATOM 8756 OG SER B 29 67.129 24.045 −2.769 1.00 50.23 B O ATOM 8758 C SER B 29 70.021 22.689 −2.717 1.00 52.24 B C ATOM 8759 O SER B 29 70.258 21.579 −3.202 1.00 53.74 B O ATOM 8761 N TRP B 30 70.662 23.796 −3.095 1.00 50.38 B N ATOM 8762 CA TRP B 30 71.696 23.793 −4.132 1.00 49.96 B C ATOM 8764 CB TRP B 30 71.494 24.969 −5.109 1.00 49.93 B C ATOM 8767 CG TRP B 30 71.028 26.273 −4.513 1.00 51.10 B C ATOM 8768 CD1 TRP B 30 69.736 26.720 −4.435 1.00 57.17 B C ATOM 8770 NE1 TRP B 30 69.700 27.965 −3.840 1.00 60.59 B N ATOM 8772 CE2 TRP B 30 70.981 28.348 −3.534 1.00 55.40 B C ATOM 8773 CD2 TRP B 30 71.846 27.311 −3.947 1.00 52.14 B C ATOM 8774 CE3 TRP B 30 73.224 27.459 −3.736 1.00 57.76 B C ATOM 8776 CZ3 TRP B 30 73.692 28.628 −3.134 1.00 59.65 B C ATOM 8778 CH2 TRP B 30 72.807 29.640 −2.735 1.00 60.19 B C ATOM 8780 CZ2 TRP B 30 71.450 29.517 −2.921 1.00 60.67 B C ATOM 8782 C TRP B 30 73.158 23.763 −3.617 1.00 48.98 B C ATOM 8783 O TRP B 30 74.074 23.547 −4.408 1.00 47.49 B O ATOM 8785 N ASP B 31 73.376 23.974 −2.317 1.00 47.96 B N ATOM 8786 CA ASP B 31 74.734 23.951 −1.732 1.00 47.91 B C ATOM 8788 CB ASP B 31 74.661 24.026 −0.202 1.00 47.75 B C ATOM 8791 CG ASP B 31 74.301 25.413 0.310 1.00 50.81 B C ATOM 8792 OD1 ASP B 31 74.399 26.417 −0.447 1.00 52.74 B O ATOM 8793 OD2 ASP B 31 73.939 25.489 1.505 1.00 54.84 B O ATOM 8794 C ASP B 31 75.545 22.705 −2.113 1.00 47.82 B C ATOM 8795 O ASP B 31 74.989 21.614 −2.241 1.00 46.75 B O ATOM 8797 N TYR B 32 76.861 22.863 −2.267 1.00 47.95 B N ATOM 8798 CA TYR B 32 77.729 21.724 −2.620 1.00 48.39 B C ATOM 8800 CB TYR B 32 79.107 22.187 −3.111 1.00 46.33 B C ATOM 8803 CG TYR B 32 79.061 22.966 −4.404 1.00 42.06 B C ATOM 8804 CD1 TYR B 32 78.597 22.375 −5.600 1.00 32.87 B C ATOM 8806 CE1 TYR B 32 78.565 23.094 −6.785 1.00 24.91 B C ATOM 8808 CZ TYR B 32 78.983 24.416 −6.780 1.00 29.67 B C ATOM 8809 OH TYR B 32 78.959 25.162 −7.917 1.00 28.02 B O ATOM 8811 CE2 TYR B 32 79.435 25.021 −5.609 1.00 33.06 B C ATOM 8813 CD2 TYR B 32 79.481 24.295 −4.442 1.00 38.13 B C ATOM 8815 C TYR B 32 77.912 20.694 −1.496 1.00 50.79 B C ATOM 8816 O TYR B 32 78.332 19.566 −1.774 1.00 49.23 B O ATOM 8818 N ASP B 33 77.621 21.082 −0.247 1.00 54.28 B N ATOM 8819 CA ASP B 33 77.619 20.140 0.897 1.00 56.96 B C ATOM 8821 CB ASP B 33 77.480 20.882 2.244 1.00 56.67 B C ATOM 8824 CG ASP B 33 78.786 21.540 2.715 1.00 54.94 B C ATOM 8825 OD1 ASP B 33 79.876 21.054 2.353 1.00 51.15 B O ATOM 8826 OD2 ASP B 33 78.720 22.540 3.471 1.00 53.38 B O ATOM 8827 C ASP B 33 76.479 19.130 0.751 1.00 60.30 B C ATOM 8828 O ASP B 33 76.675 17.922 0.940 1.00 59.85 B O ATOM 8830 N TYR B 34 75.299 19.650 0.402 1.00 64.90 B N ATOM 8831 CA TYR B 34 74.073 18.860 0.224 1.00 69.43 B C ATOM 8833 CB TYR B 34 72.841 19.789 0.239 1.00 70.86 B C ATOM 8836 CG TYR B 34 71.502 19.080 0.363 1.00 79.22 B C ATOM 8837 CD1 TYR B 34 70.964 18.781 1.617 1.00 87.20 B C ATOM 8839 CE1 TYR B 34 69.737 18.137 1.740 1.00 89.29 B C ATOM 8841 CZ TYR B 34 69.029 17.792 0.600 1.00 92.08 B C ATOM 8842 OH TYR B 34 67.812 17.157 0.722 1.00 95.47 B O ATOM 8844 CE2 TYR B 34 69.537 18.085 −0.659 1.00 89.29 B C ATOM 8846 CD2 TYR B 34 70.767 18.728 −0.770 1.00 85.21 B C ATOM 8848 C TYR B 34 74.118 18.028 −1.070 1.00 70.87 B C ATOM 8849 O TYR B 34 73.976 16.808 −1.022 1.00 71.02 B O ATOM 8851 N LEU B 35 74.306 18.686 −2.217 1.00 73.23 B N ATOM 8852 CA LEU B 35 74.646 17.990 −3.465 1.00 75.05 B C ATOM 8854 CB LEU B 35 74.518 18.928 −4.672 1.00 73.87 B C ATOM 8857 CG LEU B 35 73.181 19.646 −4.918 1.00 72.69 B C ATOM 8859 CD1 LEU B 35 73.321 20.646 −6.063 1.00 69.30 B C ATOM 8863 CD2 LEU B 35 72.033 18.678 −5.204 1.00 66.46 B C ATOM 8867 C LEU B 35 76.092 17.517 −3.304 1.00 78.50 B C ATOM 8868 O LEU B 35 76.785 17.996 −2.414 1.00 79.84 B O ATOM 8870 N LEU B 36 76.554 16.580 −4.126 1.00 81.41 B N ATOM 8871 CA LEU B 36 77.964 16.142 −4.067 1.00 84.34 B C ATOM 8873 CB LEU B 36 78.905 17.267 −4.546 1.00 84.18 B C ATOM 8876 CG LEU B 36 79.015 17.545 −6.043 1.00 85.03 B C ATOM 8878 CD1 LEU B 36 79.771 18.850 −6.269 1.00 85.63 B C ATOM 8882 CD2 LEU B 36 79.688 16.379 −6.768 1.00 84.74 B C ATOM 8886 C LEU B 36 78.429 15.663 −2.676 1.00 86.98 B C ATOM 8887 O LEU B 36 79.490 16.072 −2.193 1.00 87.19 B O ATOM 8889 N SER B 37 77.637 14.812 −2.029 1.00 90.52 B N ATOM 8890 CA SER B 37 78.077 14.126 −0.804 1.00 92.80 B C ATOM 8892 CB SER B 37 77.125 14.406 0.375 1.00 93.04 B C ATOM 8895 OG SER B 37 76.054 13.477 0.440 1.00 93.00 B O ATOM 8897 C SER B 37 78.202 12.623 −1.103 1.00 94.93 B C ATOM 8898 O SER B 37 77.529 12.105 −2.009 1.00 95.38 B O ATOM 8900 N SER B 38 79.068 11.936 −0.353 1.00 96.53 B N ATOM 8901 CA SER B 38 79.407 10.533 −0.635 1.00 97.64 B C ATOM 8903 CB SER B 38 80.710 10.135 0.070 1.00 97.75 B C ATOM 8906 OG SER B 38 80.469 9.681 1.391 1.00 98.14 B O ATOM 8908 C SER B 38 78.277 9.586 −0.222 1.00 98.41 B C ATOM 8909 O SER B 38 78.104 8.514 −0.802 1.00 98.59 B O ATOM 8911 N ILE B 44 83.839 12.635 −5.393 1.00 94.49 B N ATOM 8912 CA ILE B 44 82.761 13.547 −5.022 1.00 93.90 B C ATOM 8914 CB ILE B 44 81.411 12.780 −4.783 1.00 94.49 B C ATOM 8916 CG1 ILE B 44 81.066 11.873 −5.977 1.00 95.23 B C ATOM 8919 CD1 ILE B 44 79.671 11.239 −5.902 1.00 93.84 B C ATOM 8923 CG2 ILE B 44 80.260 13.748 −4.553 1.00 94.85 B C ATOM 8927 C ILE B 44 83.150 14.379 −3.786 1.00 92.23 B C ATOM 8928 O ILE B 44 82.375 15.230 −3.340 1.00 92.29 B O ATOM 8930 N GLU B 45 84.357 14.149 −3.257 1.00 89.93 B N ATOM 8931 CA GLU B 45 84.858 14.871 −2.079 1.00 88.17 B C ATOM 8933 CB GLU B 45 85.549 13.906 −1.114 1.00 88.70 B C ATOM 8936 CG GLU B 45 84.632 12.834 −0.533 1.00 91.80 B C ATOM 8939 CD GLU B 45 85.373 11.838 0.361 1.00 95.23 B C ATOM 8940 OE1 GLU B 45 86.408 12.215 0.962 1.00 95.84 B O ATOM 8941 OE2 GLU B 45 84.916 10.676 0.465 1.00 93.58 B O ATOM 8942 C GLU B 45 85.821 16.011 −2.435 1.00 85.13 B C ATOM 8943 O GLU B 45 85.588 17.159 −2.053 1.00 84.84 B O ATOM 8945 N VAL B 46 86.909 15.693 −3.139 1.00 81.48 B N ATOM 8946 CA VAL B 46 87.890 16.710 −3.562 1.00 78.17 B C ATOM 8948 CB VAL B 46 89.203 16.066 −4.107 1.00 78.25 B C ATOM 8950 CG1 VAL B 46 90.111 17.117 −4.756 1.00 77.80 B C ATOM 8954 CG2 VAL B 46 89.942 15.339 −2.989 1.00 78.65 B C ATOM 8958 C VAL B 46 87.271 17.647 −4.609 1.00 74.01 B C ATOM 8959 O VAL B 46 87.633 18.815 −4.691 1.00 74.42 B O ATOM 8961 N TYR B 47 86.343 17.111 −5.397 1.00 68.89 B N ATOM 8962 CA TYR B 47 85.530 17.877 −6.341 1.00 65.57 B C ATOM 8964 CB TYR B 47 84.662 16.884 −7.117 1.00 65.80 B C ATOM 8967 CG TYR B 47 83.812 17.399 −8.261 1.00 68.62 B C ATOM 8968 CD1 TYR B 47 84.261 17.333 −9.579 1.00 72.47 B C ATOM 8970 CE1 TYR B 47 83.452 17.766 −10.647 1.00 72.49 B C ATOM 8972 CZ TYR B 47 82.165 18.246 −10.397 1.00 73.07 B C ATOM 8973 OH TYR B 47 81.346 18.679 −11.437 1.00 56.23 B O ATOM 8975 CE2 TYR B 47 81.697 18.296 −9.090 1.00 72.24 B C ATOM 8977 CD2 TYR B 47 82.516 17.861 −8.036 1.00 72.42 B C ATOM 8979 C TYR B 47 84.670 18.905 −5.585 1.00 61.56 B C ATOM 8980 O TYR B 47 84.605 20.068 −5.981 1.00 60.03 B O ATOM 8982 N LYS B 48 84.041 18.471 −4.488 1.00 57.03 B N ATOM 8983 CA LYS B 48 83.250 19.350 −3.606 1.00 53.54 B C ATOM 8985 CB LYS B 48 82.637 18.549 −2.448 1.00 53.56 B C ATOM 8988 CG LYS B 48 81.822 19.383 −1.449 1.00 55.92 B C ATOM 8991 CD LYS B 48 81.250 18.518 −0.323 1.00 61.31 B C ATOM 8994 CE LYS B 48 82.258 18.292 0.806 1.00 65.33 B C ATOM 8997 NZ LYS B 48 81.669 17.565 1.968 1.00 65.45 B N ATOM 9001 C LYS B 48 84.064 20.505 −3.023 1.00 49.39 B C ATOM 9002 O LYS B 48 83.614 21.643 −3.014 1.00 48.79 B O ATOM 9004 N ASP B 49 85.252 20.197 −2.526 1.00 45.46 B N ATOM 9005 CA ASP B 49 86.102 21.189 −1.878 1.00 44.14 B C ATOM 9007 CB ASP B 49 87.217 20.505 −1.049 1.00 45.26 B C ATOM 9010 CG ASP B 49 86.675 19.718 0.166 1.00 48.58 B C ATOM 9011 OD1 ASP B 49 85.493 19.908 0.553 1.00 51.70 B O ATOM 9012 OD2 ASP B 49 87.447 18.916 0.745 1.00 47.26 B O ATOM 9013 C ASP B 49 86.707 22.135 −2.910 1.00 40.94 B C ATOM 9014 O ASP B 49 87.065 23.274 −2.581 1.00 38.32 B O ATOM 9016 N LYS B 50 86.830 21.655 −4.151 1.00 38.29 B N ATOM 9017 CA LYS B 50 87.259 22.502 −5.260 1.00 36.73 B C ATOM 9019 CB LYS B 50 87.580 21.669 −6.500 1.00 38.18 B C ATOM 9022 CG LYS B 50 88.431 22.387 −7.554 1.00 44.48 B C ATOM 9025 CD LYS B 50 89.936 22.153 −7.346 1.00 56.72 B C ATOM 9028 CE LYS B 50 90.744 22.329 −8.644 1.00 59.64 B C ATOM 9031 NZ LYS B 50 90.457 21.259 −9.654 1.00 56.87 B N ATOM 9035 C LYS B 50 86.141 23.497 −5.555 1.00 33.08 B C ATOM 9036 O LYS B 50 86.391 24.692 −5.665 1.00 32.79 B O ATOM 9038 N ALA B 51 84.905 23.011 −5.635 1.00 28.99 B N ATOM 9039 CA ALA B 51 83.779 23.878 −5.971 1.00 28.45 B C ATOM 9041 CB ALA B 51 82.493 23.070 −6.203 1.00 26.35 B C ATOM 9045 C ALA B 51 83.570 24.969 −4.908 1.00 25.62 B C ATOM 9046 O ALA B 51 83.382 26.125 −5.250 1.00 27.03 B O ATOM 9048 N LYS B 52 83.640 24.605 −3.639 1.00 23.23 B N ATOM 9049 CA LYS B 52 83.402 25.549 −2.558 1.00 25.12 B C ATOM 9051 CB LYS B 52 83.462 24.826 −1.222 1.00 26.00 B C ATOM 9054 CG LYS B 52 82.247 23.917 −0.950 1.00 32.90 B C ATOM 9057 CD LYS B 52 82.548 22.836 0.119 1.00 33.42 B C ATOM 9060 CE LYS B 52 82.519 23.382 1.545 1.00 38.08 B C ATOM 9063 NZ LYS B 52 83.221 22.478 2.543 1.00 41.70 B N ATOM 9067 C LYS B 52 84.382 26.734 −2.559 1.00 25.93 B C ATOM 9068 O LYS B 52 83.977 27.889 −2.356 1.00 25.95 B O ATOM 9070 N LYS B 53 85.659 26.441 −2.800 1.00 24.65 B N ATOM 9071 CA LYS B 53 86.713 27.468 −2.865 1.00 26.16 B C ATOM 9073 CB LYS B 53 88.072 26.795 −3.053 1.00 28.69 B C ATOM 9076 CG LYS B 53 89.272 27.687 −2.785 1.00 38.87 B C ATOM 9079 CD LYS B 53 90.559 26.848 −2.633 1.00 49.83 B C ATOM 9082 CE LYS B 53 91.819 27.730 −2.464 1.00 57.01 B C ATOM 9085 NZ LYS B 53 91.931 28.843 −3.484 1.00 55.43 B N ATOM 9089 C LYS B 53 86.476 28.458 −4.011 1.00 23.98 B C ATOM 9090 O LYS B 53 86.553 29.666 −3.818 1.00 22.54 B O ATOM 9092 N LEU B 54 86.180 27.918 −5.188 1.00 22.61 B N ATOM 9093 CA LEU B 54 85.881 28.705 −6.377 1.00 23.43 B C ATOM 9095 CB LEU B 54 85.746 27.787 −7.601 1.00 25.24 B C ATOM 9098 CG LEU B 54 86.885 26.810 −7.946 1.00 24.59 B C ATOM 9100 CD1 LEU B 54 86.382 25.820 −8.997 1.00 16.54 B C ATOM 9104 CD2 LEU B 54 88.140 27.524 −8.433 1.00 26.50 B C ATOM 9108 C LEU B 54 84.602 29.524 −6.185 1.00 22.18 B C ATOM 9109 O LEU B 54 84.580 30.696 −6.496 1.00 20.99 B O ATOM 9111 N GLU B 55 83.544 28.909 −5.656 1.00 21.18 B N ATOM 9112 CA GLU B 55 82.297 29.631 −5.346 1.00 19.85 B C ATOM 9114 CB GLU B 55 81.221 28.667 −4.811 1.00 19.93 B C ATOM 9117 CG GLU B 55 79.945 29.338 −4.252 1.00 21.78 B C ATOM 9120 CD GLU B 55 78.928 28.318 −3.683 1.00 25.47 B C ATOM 9121 OE1 GLU B 55 79.358 27.408 −2.970 1.00 25.89 B O ATOM 9122 OE2 GLU B 55 77.712 28.432 −3.943 1.00 30.12 B O ATOM 9123 C GLU B 55 82.507 30.751 −4.333 1.00 16.88 B C ATOM 9124 O GLU B 55 81.902 31.810 −4.444 1.00 18.42 B O ATOM 9126 N ALA B 56 83.331 30.498 −3.332 1.00 17.01 B N ATOM 9127 CA ALA B 56 83.662 31.512 −2.318 1.00 17.77 B C ATOM 9129 CB ALA B 56 84.639 30.933 −1.285 1.00 14.61 B C ATOM 9133 C ALA B 56 84.260 32.750 −2.974 1.00 16.65 B C ATOM 9134 O ALA B 56 83.866 33.892 −2.698 1.00 17.77 B O ATOM 9136 N GLU B 57 85.192 32.504 −3.881 1.00 17.66 B N ATOM 9137 CA GLU B 57 85.891 33.568 −4.576 1.00 19.52 B C ATOM 9139 CB GLU B 57 87.061 32.978 −5.370 1.00 20.51 B C ATOM 9142 CG GLU B 57 87.856 34.013 −6.123 1.00 28.03 B C ATOM 9145 CD GLU B 57 89.220 33.529 −6.584 1.00 29.71 B C ATOM 9146 OE1 GLU B 57 89.788 32.582 −5.980 1.00 32.81 B O ATOM 9147 OE2 GLU B 57 89.714 34.123 −7.558 1.00 32.47 B O ATOM 9148 C GLU B 57 84.926 34.373 −5.464 1.00 18.10 B C ATOM 9149 O GLU B 57 84.956 35.612 −5.451 1.00 17.86 B O ATOM 9151 N VAL B 58 84.052 33.683 −6.201 1.00 15.98 B N ATOM 9152 CA VAL B 58 83.038 34.371 −6.998 1.00 15.98 B C ATOM 9154 CB VAL B 58 82.222 33.394 −7.875 1.00 18.04 B C ATOM 9156 CG1 VAL B 58 81.131 34.128 −8.663 1.00 15.64 B C ATOM 9160 CG2 VAL B 58 83.138 32.696 −8.844 1.00 18.23 B C ATOM 9164 C VAL B 58 82.135 35.203 −6.089 1.00 14.38 B C ATOM 9165 O VAL B 58 81.813 36.330 −6.395 1.00 12.91 B O ATOM 9167 N ARG B 59 81.773 34.666 −4.935 1.00 18.23 B N ATOM 9168 CA ARG B 59 80.953 35.412 −3.976 1.00 19.65 B C ATOM 9170 CB ARG B 59 80.619 34.534 −2.741 1.00 22.03 B C ATOM 9173 CG ARG B 59 79.877 35.245 −1.579 1.00 22.47 B C ATOM 9176 CD ARG B 59 80.840 36.086 −0.641 1.00 25.58 B C ATOM 9179 NE ARG B 59 80.117 36.788 0.431 1.00 24.31 B N ATOM 9181 CZ ARG B 59 80.644 37.698 1.250 1.00 27.67 B C ATOM 9182 NH1 ARG B 59 79.881 38.260 2.182 1.00 25.80 B N ATOM 9185 NH2 ARG B 59 81.926 38.056 1.146 1.00 25.89 B N ATOM 9188 C ARG B 59 81.673 36.705 −3.578 1.00 19.80 B C ATOM 9189 O ARG B 59 81.077 37.780 −3.578 1.00 21.68 B O ATOM 9191 N ARG B 60 82.953 36.603 −3.241 1.00 20.03 B N ATOM 9192 CA ARG B 60 83.717 37.782 −2.820 1.00 18.94 B C ATOM 9194 CB ARG B 60 85.145 37.411 −2.468 1.00 19.04 B C ATOM 9197 CG ARG B 60 86.020 38.589 −2.002 1.00 22.87 B C ATOM 9200 CD ARG B 60 87.442 38.164 −1.777 1.00 19.95 B C ATOM 9203 NE ARG B 60 88.075 37.838 −3.049 1.00 25.88 B N ATOM 9205 CZ ARG B 60 89.176 37.106 −3.209 1.00 26.18 B C ATOM 9206 NH1 ARG B 60 89.836 36.578 −2.176 1.00 24.93 B N ATOM 9209 NH2 ARG B 60 89.620 36.904 −4.435 1.00 23.40 B N ATOM 9212 C ARG B 60 83.718 38.843 −3.915 1.00 18.30 B C ATOM 9213 O ARG B 60 83.427 40.007 −3.650 1.00 16.21 B O ATOM 9215 N GLU B 61 84.015 38.434 −5.140 1.00 18.15 B N ATOM 9216 CA GLU B 61 84.066 39.367 −6.264 1.00 18.45 B C ATOM 9218 CB GLU B 61 84.564 38.663 −7.523 1.00 18.70 B C ATOM 9221 CG GLU B 61 86.037 38.270 −7.425 1.00 25.62 B C ATOM 9224 CD GLU B 61 86.901 39.429 −6.970 1.00 31.59 B C ATOM 9225 OE1 GLU B 61 86.893 40.488 −7.648 1.00 33.81 B O ATOM 9226 OE2 GLU B 61 87.559 39.290 −5.918 1.00 30.53 B O ATOM 9227 C GLU B 61 82.734 40.062 −6.528 1.00 17.97 B C ATOM 9228 O GLU B 61 82.711 41.245 −6.761 1.00 19.38 B O ATOM 9230 N ILE B 62 81.617 39.356 −6.435 1.00 17.52 B N ATOM 9231 CA ILE B 62 80.341 40.023 −6.594 1.00 18.58 B C ATOM 9233 CB ILE B 62 79.169 39.006 −6.731 1.00 19.89 B C ATOM 9235 CG1 ILE B 62 79.343 38.137 −7.974 1.00 21.73 B C ATOM 9238 CD1 ILE B 62 78.456 36.881 −8.000 1.00 15.32 B C ATOM 9242 CG2 ILE B 62 77.810 39.738 −6.823 1.00 21.38 B C ATOM 9246 C ILE B 62 80.071 41.005 −5.433 1.00 19.09 B C ATOM 9247 O ILE B 62 79.379 41.984 −5.615 1.00 20.23 B O ATOM 9249 N ASN B 63 80.606 40.732 −4.244 1.00 20.89 B N ATOM 9250 CA ASN B 63 80.300 41.510 −3.024 1.00 21.02 B C ATOM 9252 CB ASN B 63 80.355 40.597 −1.783 1.00 20.11 B C ATOM 9255 CG ASN B 63 79.061 39.859 −1.543 1.00 25.79 B C ATOM 9256 OD1 ASN B 63 78.128 40.417 −0.976 1.00 29.46 B O ATOM 9257 ND2 ASN B 63 78.999 38.591 −1.957 1.00 22.36 B N ATOM 9260 C ASN B 63 81.262 42.671 −2.838 1.00 23.00 B C ATOM 9261 O ASN B 63 81.077 43.514 −1.968 1.00 22.33 B O ATOM 9263 N ASN B 64 82.292 42.697 −3.674 1.00 25.47 B N ATOM 9264 CA ASN B 64 83.322 43.708 −3.630 1.00 27.17 B C ATOM 9266 CB ASN B 64 84.400 43.341 −4.646 1.00 28.05 B C ATOM 9269 CG ASN B 64 85.562 44.319 −4.642 1.00 28.60 B C ATOM 9270 OD1 ASN B 64 85.793 45.052 −3.663 1.00 21.94 B O ATOM 9271 ND2 ASN B 64 86.299 44.331 −5.732 1.00 18.57 B N ATOM 9274 C ASN B 64 82.840 45.121 −3.922 1.00 29.58 B C ATOM 9275 O ASN B 64 82.518 45.441 −5.073 1.00 30.80 B O ATOM 9277 N GLU B 65 82.848 45.977 −2.901 1.00 31.46 B N ATOM 9278 CA GLU B 65 82.308 47.333 −3.039 1.00 34.52 B C ATOM 9280 CB GLU B 65 81.787 47.849 −1.680 1.00 36.07 B C ATOM 9283 CG GLU B 65 80.519 47.079 −1.202 1.00 40.76 B C ATOM 9286 CD GLU B 65 79.853 47.631 0.070 1.00 46.69 B C ATOM 9287 OE1 GLU B 65 79.267 46.807 0.819 1.00 45.52 B O ATOM 9288 OE2 GLU B 65 79.891 48.862 0.314 1.00 44.38 B O ATOM 9289 C GLU B 65 83.299 48.314 −3.700 1.00 34.91 B C ATOM 9290 O GLU B 65 82.903 49.396 −4.110 1.00 35.59 B O ATOM 9292 N LYS B 66 84.561 47.909 −3.843 1.00 34.28 B N ATOM 9293 CA LYS B 66 85.599 48.730 −4.488 1.00 35.18 B C ATOM 9295 CB LYS B 66 86.982 48.469 −3.863 1.00 35.99 B C ATOM 9298 CG LYS B 66 87.045 48.467 −2.339 1.00 38.17 B C ATOM 9301 CD LYS B 66 88.463 48.112 −1.873 1.00 44.44 B C ATOM 9304 CE LYS B 66 88.568 47.948 −0.356 1.00 45.69 B C ATOM 9307 NZ LYS B 66 87.722 48.925 0.382 1.00 46.38 B N ATOM 9311 C LYS B 66 85.706 48.474 −5.997 1.00 33.33 B C ATOM 9312 O LYS B 66 86.472 49.135 −6.685 1.00 31.57 B O ATOM 9314 N ALA B 67 84.959 47.506 −6.507 1.00 33.36 B N ATOM 9315 CA ALA B 67 85.026 47.165 −7.925 1.00 34.20 B C ATOM 9317 CB ALA B 67 84.218 45.897 −8.204 1.00 33.29 B C ATOM 9321 C ALA B 67 84.525 48.322 −8.800 1.00 33.66 B C ATOM 9322 O ALA B 67 83.650 49.084 −8.405 1.00 30.94 B O ATOM 9324 N GLU B 68 85.105 48.461 −9.983 1.00 35.83 B N ATOM 9325 CA GLU B 68 84.593 49.428 −10.952 1.00 38.70 B C ATOM 9327 CB GLU B 68 85.515 49.528 −12.176 1.00 40.06 B C ATOM 9330 CG GLU B 68 85.648 50.931 −12.771 1.00 49.30 B C ATOM 9333 CD GLU B 68 86.723 51.762 −12.087 1.00 60.51 B C ATOM 9334 OE1 GLU B 68 86.676 51.895 −10.839 1.00 64.15 B O ATOM 9335 OE2 GLU B 68 87.615 52.287 −12.800 1.00 64.74 B O ATOM 9336 C GLU B 68 83.188 48.938 −11.336 1.00 38.52 B C ATOM 9337 O GLU B 68 82.979 47.736 −11.557 1.00 35.34 B O ATOM 9339 N PHE B 69 82.231 49.862 −11.388 1.00 39.72 B N ATOM 9340 CA PHE B 69 80.824 49.499 −11.583 1.00 40.88 B C ATOM 9342 CB PHE B 69 79.890 50.704 −11.385 1.00 43.17 B C ATOM 9345 CG PHE B 69 79.457 50.916 −9.936 1.00 53.21 B C ATOM 9346 CD1 PHE B 69 78.868 49.875 −9.202 1.00 61.30 B C ATOM 9348 CE1 PHE B 69 78.463 50.062 −7.870 1.00 62.25 B C ATOM 9350 CZ PHE B 69 78.638 51.301 −7.260 1.00 64.99 B C ATOM 9352 CE2 PHE B 69 79.218 52.351 −7.978 1.00 65.67 B C ATOM 9354 CD2 PHE B 69 79.621 52.156 −9.312 1.00 63.60 B C ATOM 9356 C PHE B 69 80.540 48.786 −12.914 1.00 38.20 B C ATOM 9357 O PHE B 69 79.713 47.862 −12.946 1.00 35.79 B O ATOM 9359 N LEU B 70 81.237 49.159 −13.983 1.00 34.86 B N ATOM 9360 CA LEU B 70 81.085 48.435 −15.256 1.00 35.39 B C ATOM 9362 CB LEU B 70 81.786 49.157 −16.411 1.00 35.66 B C ATOM 9365 CG LEU B 70 81.573 48.513 −17.786 1.00 42.16 B C ATOM 9367 CD1 LEU B 70 80.104 48.554 −18.171 1.00 42.12 B C ATOM 9371 CD2 LEU B 70 82.425 49.189 −18.855 1.00 49.16 B C ATOM 9375 C LEU B 70 81.603 46.999 −15.160 1.00 32.47 B C ATOM 9376 O LEU B 70 80.945 46.071 −15.596 1.00 31.99 B O ATOM 9378 N THR B 71 82.790 46.834 −14.592 1.00 31.77 B N ATOM 9379 CA THR B 71 83.396 45.516 −14.366 1.00 30.39 B C ATOM 9381 CB THR B 71 84.794 45.678 −13.756 1.00 31.06 B C ATOM 9383 OG1 THR B 71 85.585 46.494 −14.633 1.00 34.93 B O ATOM 9385 CG2 THR B 71 85.476 44.322 −13.563 1.00 31.45 B C ATOM 9389 C THR B 71 82.533 44.619 −13.460 1.00 27.80 B C ATOM 9390 O THR B 71 82.450 43.412 −13.675 1.00 27.97 B O ATOM 9392 N LEU B 72 81.878 45.215 −12.467 1.00 25.13 B N ATOM 9393 CA LEU B 72 80.955 44.476 −11.614 1.00 24.98 B C ATOM 9395 CB LEU B 72 80.511 45.327 −10.443 1.00 24.24 B C ATOM 9398 CG LEU B 72 79.716 44.642 −9.339 1.00 33.31 B C ATOM 9400 CD1 LEU B 72 80.492 43.465 −8.715 1.00 32.42 B C ATOM 9404 CD2 LEU B 72 79.346 45.677 −8.266 1.00 35.81 B C ATOM 9408 C LEU B 72 79.736 44.026 −12.410 1.00 24.17 B C ATOM 9409 O LEU B 72 79.330 42.888 −12.318 1.00 21.92 B O ATOM 9411 N LEU B 73 79.158 44.928 −13.196 1.00 24.75 B N ATOM 9412 CA LEU B 73 78.018 44.568 −14.012 1.00 25.30 B C ATOM 9414 CB LEU B 73 77.467 45.786 −14.758 1.00 25.87 B C ATOM 9417 CG LEU B 73 76.666 46.820 −13.948 1.00 26.49 B C ATOM 9419 CD1 LEU B 73 76.237 47.980 −14.845 1.00 24.24 B C ATOM 9423 CD2 LEU B 73 75.462 46.210 −13.265 1.00 20.11 B C ATOM 9427 C LEU B 73 78.383 43.437 −14.996 1.00 24.80 B C ATOM 9428 O LEU B 73 77.630 42.492 −15.150 1.00 24.71 B O ATOM 9430 N GLU B 74 79.530 43.526 −15.650 1.00 23.04 B N ATOM 9431 CA GLU B 74 79.934 42.456 −16.561 1.00 24.32 B C ATOM 9433 CB GLU B 74 81.164 42.873 −17.383 1.00 24.31 B C ATOM 9436 CG GLU B 74 80.842 43.894 −18.492 1.00 35.06 B C ATOM 9439 CD GLU B 74 82.069 44.669 −19.044 1.00 42.57 B C ATOM 9440 OE1 GLU B 74 83.235 44.254 −18.819 1.00 41.46 B O ATOM 9441 OE2 GLU B 74 81.844 45.714 −19.713 1.00 49.19 B O ATOM 9442 C GLU B 74 80.187 41.124 −15.811 1.00 23.65 B C ATOM 9443 O GLU B 74 79.951 40.034 −16.343 1.00 24.23 B O ATOM 9445 N LEU B 75 80.667 41.208 −14.579 1.00 22.21 B N ATOM 9446 CA LEU B 75 80.888 40.012 −13.794 1.00 20.79 B C ATOM 9448 CB LEU B 75 81.548 40.334 −12.445 1.00 19.72 B C ATOM 9451 CG LEU B 75 81.715 39.168 −11.461 1.00 19.52 B C ATOM 9453 CD1 LEU B 75 82.486 38.032 −12.119 1.00 16.13 B C ATOM 9457 CD2 LEU B 75 82.437 39.647 −10.211 1.00 21.45 B C ATOM 9461 C LEU B 75 79.553 39.335 −13.576 1.00 19.44 B C ATOM 9462 O LEU B 75 79.445 38.130 −13.753 1.00 21.48 B O ATOM 9464 N ILE B 76 78.543 40.115 −13.197 1.00 19.42 B N ATOM 9465 CA ILE B 76 77.230 39.579 −12.907 1.00 21.46 B C ATOM 9467 CB ILE B 76 76.256 40.654 −12.379 1.00 23.58 B C ATOM 9469 CG1 ILE B 76 76.708 41.135 −10.996 1.00 24.75 B C ATOM 9472 CD1 ILE B 76 75.987 42.362 −10.509 1.00 22.54 B C ATOM 9476 CG2 ILE B 76 74.826 40.102 −12.297 1.00 15.99 B C ATOM 9480 C ILE B 76 76.632 38.972 −14.151 1.00 23.08 B C ATOM 9481 O ILE B 76 75.984 37.933 −14.081 1.00 24.81 B O ATOM 9483 N ASP B 77 76.854 39.610 −15.293 1.00 23.68 B N ATOM 9484 CA ASP B 77 76.279 39.122 −16.545 1.00 23.98 B C ATOM 9486 CB ASP B 77 76.545 40.109 −17.669 1.00 24.72 B C ATOM 9489 CG ASP B 77 75.708 39.838 −18.906 1.00 28.60 B C ATOM 9490 OD1 ASP B 77 74.657 39.176 −18.811 1.00 27.91 B O ATOM 9491 OD2 ASP B 77 76.095 40.332 −19.984 1.00 33.20 B O ATOM 9492 C ASP B 77 76.900 37.791 −16.896 1.00 22.93 B C ATOM 9493 O ASP B 77 76.206 36.855 −17.301 1.00 21.74 B O ATOM 9495 N ASN B 78 78.211 37.703 −16.733 1.00 21.06 B N ATOM 9496 CA ASN B 78 78.925 36.463 −17.029 1.00 22.27 B C ATOM 9498 CB ASN B 78 80.438 36.637 −16.866 1.00 25.30 B C ATOM 9501 CG ASN B 78 81.081 37.404 −18.019 1.00 26.72 B C ATOM 9502 OD1 ASN B 78 80.708 37.233 −19.156 1.00 23.36 B O ATOM 9503 ND2 ASN B 78 82.081 38.219 −17.714 1.00 21.70 B N ATOM 9506 C ASN B 78 78.458 35.353 −16.109 1.00 21.56 B C ATOM 9507 O ASN B 78 78.201 34.240 −16.549 1.00 20.19 B O ATOM 9509 N VAL B 79 78.340 35.664 −14.825 1.00 20.29 B N ATOM 9510 CA VAL B 79 77.917 34.672 −13.843 1.00 21.77 B C ATOM 9512 CB VAL B 79 77.857 35.306 −12.419 1.00 23.62 B C ATOM 9514 CG1 VAL B 79 77.001 34.467 −11.466 1.00 19.36 B C ATOM 9518 CG2 VAL B 79 79.265 35.515 −11.862 1.00 19.30 B C ATOM 9522 C VAL B 79 76.552 34.064 −14.217 1.00 22.02 B C ATOM 9523 O VAL B 79 76.349 32.862 −14.107 1.00 22.00 B O ATOM 9525 N GLN B 80 75.630 34.910 −14.672 1.00 21.01 B N ATOM 9526 CA GLN B 80 74.265 34.482 −15.024 1.00 19.29 B C ATOM 9528 CB GLN B 80 73.343 35.686 −15.126 1.00 15.00 B C ATOM 9531 CG GLN B 80 73.128 36.374 −13.771 1.00 17.76 B C ATOM 9534 CD GLN B 80 71.957 37.344 −13.766 1.00 21.46 B C ATOM 9535 OE1 GLN B 80 71.283 37.519 −12.744 1.00 24.61 B O ATOM 9536 NE2 GLN B 80 71.702 37.966 −14.903 1.00 18.12 B N ATOM 9539 C GLN B 80 74.244 33.713 −16.339 1.00 21.60 B C ATOM 9540 O GLN B 80 73.655 32.624 −16.426 1.00 23.34 B O ATOM 9542 N ARG B 81 74.930 34.258 −17.340 1.00 19.85 B N ATOM 9543 CA ARG B 81 75.018 33.618 −18.651 1.00 21.31 B C ATOM 9545 CB ARG B 81 75.744 34.528 −19.651 1.00 22.39 B C ATOM 9548 CG ARG B 81 74.902 35.779 −19.950 1.00 24.93 B C ATOM 9551 CD ARG B 81 75.364 36.514 −21.183 1.00 27.95 B C ATOM 9554 NE ARG B 81 75.370 35.628 −22.346 1.00 33.40 B N ATOM 9556 CZ ARG B 81 75.597 36.035 −23.594 1.00 44.92 B C ATOM 9557 NH1 ARG B 81 75.801 37.326 −23.849 1.00 43.90 B N ATOM 9560 NH2 ARG B 81 75.593 35.149 −24.597 1.00 41.12 B N ATOM 9563 C ARG B 81 75.669 32.256 −18.590 1.00 20.24 B C ATOM 9564 O ARG B 81 75.228 31.322 −19.268 1.00 23.90 B O ATOM 9566 N LEU B 82 76.683 32.119 −17.747 1.00 18.56 B N ATOM 9567 CA LEU B 82 77.374 30.837 −17.558 1.00 17.31 B C ATOM 9569 CB LEU B 82 78.723 31.056 −16.857 1.00 17.11 B C ATOM 9572 CG LEU B 82 79.810 31.804 −17.660 1.00 23.24 B C ATOM 9574 CD1 LEU B 82 80.870 32.349 −16.695 1.00 14.65 B C ATOM 9578 CD2 LEU B 82 80.450 30.919 −18.756 1.00 16.24 B C ATOM 9582 C LEU B 82 76.546 29.833 −16.757 1.00 16.56 B C ATOM 9583 O LEU B 82 76.966 28.708 −16.571 1.00 17.24 B O ATOM 9585 N GLY B 83 75.391 30.245 −16.253 1.00 19.51 B N ATOM 9586 CA GLY B 83 74.459 29.326 −15.600 1.00 20.32 B C ATOM 9589 C GLY B 83 74.479 29.334 −14.085 1.00 21.68 B C ATOM 9590 O GLY B 83 73.823 28.495 −13.459 1.00 24.50 B O ATOM 9592 N LEU B 84 75.188 30.288 −13.480 1.00 21.90 B N ATOM 9593 CA LEU B 84 75.440 30.252 −12.043 1.00 23.56 B C ATOM 9595 CB LEU B 84 76.918 30.462 −11.762 1.00 21.53 B C ATOM 9598 CG LEU B 84 77.914 29.392 −12.227 1.00 22.51 B C ATOM 9600 CD1 LEU B 84 79.332 30.012 −12.350 1.00 17.35 B C ATOM 9604 CD2 LEU B 84 77.936 28.211 −11.274 1.00 14.52 B C ATOM 9608 C LEU B 84 74.614 31.286 −11.267 1.00 24.75 B C ATOM 9609 O LEU B 84 74.793 31.464 −10.050 1.00 23.23 B O ATOM 9611 N GLY B 85 73.704 31.946 −11.957 1.00 20.07 B N ATOM 9612 CA GLY B 85 72.905 32.986 −11.331 1.00 23.42 B C ATOM 9615 C GLY B 85 72.103 32.548 −10.128 1.00 23.55 B C ATOM 9616 O GLY B 85 72.051 33.276 −9.129 1.00 24.14 B O ATOM 9618 N TYR B 86 71.493 31.358 −10.216 1.00 25.41 B N ATOM 9619 CA TYR B 86 70.653 30.780 −9.138 1.00 24.89 B C ATOM 9621 CB TYR B 86 70.088 29.405 −9.555 1.00 23.46 B C ATOM 9624 CG TYR B 86 71.098 28.272 −9.477 1.00 20.27 B C ATOM 9625 CD1 TYR B 86 71.113 27.378 −8.409 1.00 18.85 B C ATOM 9627 CE1 TYR B 86 72.051 26.334 −8.361 1.00 21.28 B C ATOM 9629 CZ TYR B 86 72.972 26.173 −9.391 1.00 21.08 B C ATOM 9630 OH TYR B 86 73.936 25.171 −9.372 1.00 14.76 B O ATOM 9632 CE2 TYR B 86 72.949 27.035 −10.447 1.00 15.78 B C ATOM 9634 CD2 TYR B 86 72.029 28.084 −10.477 1.00 18.71 B C ATOM 9636 C TYR B 86 71.418 30.580 −7.843 1.00 27.93 B C ATOM 9637 O TYR B 86 70.847 30.313 −6.788 1.00 29.61 B O ATOM 9639 N ARG B 87 72.730 30.655 −7.953 1.00 27.91 B N ATOM 9640 CA ARG B 87 73.620 30.275 −6.899 1.00 27.88 B C ATOM 9642 CB ARG B 87 74.812 29.611 −7.587 1.00 30.15 B C ATOM 9645 CG ARG B 87 75.709 28.864 −6.734 1.00 30.85 B C ATOM 9648 CD ARG B 87 76.316 27.640 −7.442 1.00 29.13 B C ATOM 9651 NE ARG B 87 76.612 26.804 −6.332 1.00 26.20 B N ATOM 9653 CZ ARG B 87 75.932 25.744 −5.944 1.00 24.61 B C ATOM 9654 NH1 ARG B 87 76.289 25.177 −4.803 1.00 36.76 B N ATOM 9657 NH2 ARG B 87 74.970 25.210 −6.680 1.00 26.43 B N ATOM 9660 C ARG B 87 74.038 31.512 −6.147 1.00 27.03 B C ATOM 9661 O ARG B 87 74.506 31.421 −5.028 1.00 25.59 B O ATOM 9663 N PHE B 88 73.855 32.679 −6.776 1.00 28.24 B N ATOM 9664 CA PHE B 88 74.438 33.940 −6.297 1.00 28.26 B C ATOM 9666 CB PHE B 88 75.605 34.341 −7.210 1.00 25.39 B C ATOM 9669 CG PHE B 88 76.807 33.456 −7.079 1.00 25.44 B C ATOM 9670 CD1 PHE B 88 77.569 33.468 −5.924 1.00 18.49 B C ATOM 9672 CE1 PHE B 88 78.678 32.671 −5.811 1.00 25.00 B C ATOM 9674 CZ PHE B 88 79.048 31.820 −6.862 1.00 22.42 B C ATOM 9676 CE2 PHE B 88 78.292 31.788 −8.000 1.00 19.97 B C ATOM 9678 CD2 PHE B 88 77.180 32.609 −8.112 1.00 21.12 B C ATOM 9680 C PHE B 88 73.404 35.074 −6.240 1.00 29.32 B C ATOM 9681 O PHE B 88 73.756 36.270 −6.250 1.00 29.34 B O ATOM 9683 N GLU B 89 72.140 34.695 −6.141 1.00 29.21 B N ATOM 9684 CA GLU B 89 71.049 35.650 −6.224 1.00 32.70 B C ATOM 9686 CB GLU B 89 69.701 34.937 −6.103 1.00 33.74 B C ATOM 9689 CG GLU B 89 68.512 35.887 −6.195 1.00 45.69 B C ATOM 9692 CD GLU B 89 67.208 35.206 −6.586 1.00 55.76 B C ATOM 9693 OE1 GLU B 89 67.250 34.124 −7.225 1.00 57.29 B O ATOM 9694 OE2 GLU B 89 66.142 35.787 −6.272 1.00 58.91 B O ATOM 9695 C GLU B 89 71.156 36.755 −5.186 1.00 31.50 B C ATOM 9696 O GLU B 89 71.011 37.913 −5.516 1.00 33.00 B O ATOM 9698 N SER B 90 71.421 36.425 −3.935 1.00 31.61 B N ATOM 9699 CA SER B 90 71.404 37.470 −2.907 1.00 31.80 B C ATOM 9701 CB SER B 90 71.315 36.860 −1.490 1.00 32.58 B C ATOM 9704 OG SER B 90 72.570 36.431 −0.986 1.00 41.51 B O ATOM 9706 C SER B 90 72.600 38.420 −3.061 1.00 29.63 B C ATOM 9707 O SER B 90 72.524 39.599 −2.730 1.00 30.79 B O ATOM 9709 N ASP B 91 73.707 37.902 −3.576 1.00 26.77 B N ATOM 9710 CA ASP B 91 74.889 38.721 −3.783 1.00 24.01 B C ATOM 9712 CB ASP B 91 76.103 37.821 −4.010 1.00 25.50 B C ATOM 9715 CG ASP B 91 76.251 36.765 −2.909 1.00 26.74 B C ATOM 9716 OD1 ASP B 91 76.655 37.118 −1.779 1.00 29.64 B O ATOM 9717 OD2 ASP B 91 75.922 35.587 −3.167 1.00 39.56 B O ATOM 9718 C ASP B 91 74.638 39.638 −4.962 1.00 22.71 B C ATOM 9719 O ASP B 91 74.987 40.816 −4.931 1.00 19.92 B O ATOM 9721 N ILE B 92 73.984 39.105 −5.989 1.00 22.65 B N ATOM 9722 CA ILE B 92 73.661 39.888 −7.185 1.00 22.89 B C ATOM 9724 CB ILE B 92 73.071 39.000 −8.272 1.00 22.20 B C ATOM 9726 CG1 ILE B 92 74.203 38.179 −8.899 1.00 22.79 B C ATOM 9729 CD1 ILE B 92 73.755 36.921 −9.639 1.00 17.50 B C ATOM 9733 CG2 ILE B 92 72.332 39.853 −9.316 1.00 20.85 B C ATOM 9737 C ILE B 92 72.710 41.049 −6.869 1.00 24.13 B C ATOM 9738 O ILE B 92 72.974 42.200 −7.246 1.00 22.72 B O ATOM 9740 N ARG B 93 71.624 40.744 −6.167 1.00 24.93 B N ATOM 9741 CA ARG B 93 70.659 41.766 −5.731 1.00 27.69 B C ATOM 9743 CB ARG B 93 69.522 41.150 −4.895 1.00 29.92 B C ATOM 9746 CG ARG B 93 68.573 40.217 −5.631 1.00 32.70 B C ATOM 9749 CD ARG B 93 67.427 39.746 −4.685 1.00 39.32 B C ATOM 9752 NE ARG B 93 66.650 40.894 −4.231 1.00 40.88 B N ATOM 9754 CZ ARG B 93 65.793 41.575 −4.993 1.00 47.67 B C ATOM 9755 NH1 ARG B 93 65.565 41.216 −6.262 1.00 47.75 B N ATOM 9758 NH2 ARG B 93 65.147 42.622 −4.484 1.00 51.17 B N ATOM 9761 C ARG B 93 71.322 42.797 −4.865 1.00 26.85 B C ATOM 9762 O ARG B 93 71.039 43.980 −4.983 1.00 28.19 B O ATOM 9764 N GLY B 94 72.186 42.340 −3.966 1.00 26.87 B N ATOM 9765 CA GLY B 94 72.934 43.248 −3.122 1.00 27.08 B C ATOM 9768 C GLY B 94 73.776 44.208 −3.939 1.00 27.51 B C ATOM 9769 O GLY B 94 73.809 45.401 −3.656 1.00 31.87 B O ATOM 9771 N ALA B 95 74.464 43.704 −4.957 1.00 25.26 B N ATOM 9772 CA ALA B 95 75.283 44.564 −5.793 1.00 23.60 B C ATOM 9774 CB ALA B 95 76.133 43.743 −6.728 1.00 21.73 B C ATOM 9778 C ALA B 95 74.397 45.521 −6.578 1.00 23.80 B C ATOM 9779 O ALA B 95 74.670 46.712 −6.666 1.00 23.61 B O ATOM 9781 N LEU B 96 73.322 45.005 −7.152 1.00 25.22 B N ATOM 9782 CA LEU B 96 72.452 45.858 −7.955 1.00 26.19 B C ATOM 9784 CB LEU B 96 71.359 45.040 −8.659 1.00 25.27 B C ATOM 9787 CG LEU B 96 71.931 44.096 −9.719 1.00 26.21 B C ATOM 9789 CD1 LEU B 96 70.839 43.152 −10.263 1.00 20.34 B C ATOM 9793 CD2 LEU B 96 72.591 44.898 −10.840 1.00 19.97 B C ATOM 9797 C LEU B 96 71.855 46.943 −7.070 1.00 27.60 B C ATOM 9798 O LEU B 96 71.741 48.080 −7.486 1.00 25.32 B O ATOM 9800 N ASP B 97 71.510 46.589 −5.834 1.00 30.71 B N ATOM 9801 CA ASP B 97 70.894 47.534 −4.922 1.00 34.41 B C ATOM 9803 CB ASP B 97 70.407 46.810 −3.668 1.00 36.18 B C ATOM 9806 CG ASP B 97 69.603 47.704 −2.770 1.00 46.19 B C ATOM 9807 OD1 ASP B 97 70.026 47.902 −1.611 1.00 56.68 B O ATOM 9808 OD2 ASP B 97 68.567 48.239 −3.235 1.00 53.71 B O ATOM 9809 C ASP B 97 71.855 48.672 −4.568 1.00 35.18 B C ATOM 9810 O ASP B 97 71.452 49.829 −4.438 1.00 35.44 B O ATOM 9812 N ARG B 98 73.128 48.328 −4.428 1.00 37.40 B N ATOM 9813 CA ARG B 98 74.183 49.305 −4.148 1.00 38.06 B C ATOM 9815 CB ARG B 98 75.536 48.601 −3.947 1.00 39.12 B C ATOM 9818 CG ARG B 98 76.260 48.876 −2.626 1.00 41.93 B C ATOM 9821 CD ARG B 98 76.328 47.616 −1.786 1.00 44.63 B C ATOM 9824 NE ARG B 98 77.027 46.541 −2.495 1.00 40.39 B N ATOM 9826 CZ ARG B 98 76.878 45.243 −2.248 1.00 33.84 B C ATOM 9827 NH1 ARG B 98 76.044 44.819 −1.303 1.00 38.65 B N ATOM 9830 NH2 ARG B 98 77.564 44.360 −2.963 1.00 35.04 B N ATOM 9833 C ARG B 98 74.298 50.240 −5.337 1.00 37.03 B C ATOM 9834 O ARG B 98 74.388 51.452 −5.189 1.00 35.80 B O ATOM 9836 N PHE B 99 74.289 49.641 −6.522 1.00 36.87 B N ATOM 9837 CA PHE B 99 74.457 50.365 −7.767 1.00 36.19 B C ATOM 9839 CB PHE B 99 74.402 49.380 −8.927 1.00 36.62 B C ATOM 9842 CG PHE B 99 74.636 49.997 −10.260 1.00 33.49 B C ATOM 9843 CD1 PHE B 99 75.826 50.641 −10.534 1.00 38.87 B C ATOM 9845 CE1 PHE B 99 76.054 51.211 −11.773 1.00 37.59 B C ATOM 9847 CZ PHE B 99 75.087 51.116 −12.749 1.00 36.98 B C ATOM 9849 CE2 PHE B 99 73.901 50.457 −12.486 1.00 29.58 B C ATOM 9851 CD2 PHE B 99 73.677 49.916 −11.252 1.00 33.52 B C ATOM 9853 C PHE B 99 73.396 51.431 −7.953 1.00 36.68 B C ATOM 9854 O PHE B 99 73.686 52.516 −8.465 1.00 37.64 B O ATOM 9856 N VAL B 100 72.170 51.134 −7.540 1.00 36.30 B N ATOM 9857 CA VAL B 100 71.102 52.123 −7.615 1.00 38.42 B C ATOM 9859 CB VAL B 100 69.704 51.479 −7.546 1.00 39.36 B C ATOM 9861 CG1 VAL B 100 68.625 52.555 −7.520 1.00 38.06 B C ATOM 9865 CG2 VAL B 100 69.486 50.541 −8.738 1.00 35.08 B C ATOM 9869 C VAL B 100 71.258 53.138 −6.489 1.00 40.92 B C ATOM 9870 O VAL B 100 71.400 54.336 −6.745 1.00 41.13 B O ATOM 9872 N SER B 101 71.261 52.643 −5.251 1.00 42.85 B N ATOM 9873 CA SER B 101 71.290 53.499 −4.056 1.00 44.85 B C ATOM 9875 CB SER B 101 71.364 52.641 −2.783 1.00 45.99 B C ATOM 9878 OG SER B 101 72.670 52.116 −2.592 1.00 48.88 B O ATOM 9880 C SER B 101 72.435 54.514 −4.026 1.00 44.67 B C ATOM 9881 O SER B 101 72.314 55.554 −3.390 1.00 45.09 B O ATOM 9883 N SER B 102 73.546 54.195 −4.685 1.00 44.99 B N ATOM 9884 CA SER B 102 74.709 55.078 −4.710 1.00 45.30 B C ATOM 9886 CB SER B 102 76.001 54.249 −4.754 1.00 45.54 B C ATOM 9889 OG SER B 102 76.305 53.829 −6.074 1.00 46.99 B O ATOM 9891 C SER B 102 74.680 56.051 −5.892 1.00 44.38 B C ATOM 9892 O SER B 102 75.651 56.748 −6.133 1.00 44.36 B O ATOM 9894 N GLY B 103 73.579 56.086 −6.632 1.00 45.09 B N ATOM 9895 CA GLY B 103 73.474 56.931 −7.820 1.00 46.00 B C ATOM 9898 C GLY B 103 74.299 56.453 −9.007 1.00 45.92 B C ATOM 9899 O GLY B 103 74.416 57.159 −10.016 1.00 45.89 B O ATOM 9901 N GLY B 104 74.861 55.251 −8.900 1.00 45.67 B N ATOM 9902 CA GLY B 104 75.678 54.681 −9.965 1.00 45.47 B C ATOM 9905 C GLY B 104 74.878 54.459 −11.234 1.00 45.06 B C ATOM 9906 O GLY B 104 75.402 54.617 −12.343 1.00 46.05 B O ATOM 9908 N PHE B 105 73.603 54.114 −11.074 1.00 43.92 B N ATOM 9909 CA PHE B 105 72.735 53.885 −12.220 1.00 44.36 B C ATOM 9911 CB PHE B 105 71.423 53.191 −11.814 1.00 42.94 B C ATOM 9914 CG PHE B 105 70.454 53.021 −12.957 1.00 42.37 B C ATOM 9915 CD1 PHE B 105 70.829 52.332 −14.103 1.00 36.91 B C ATOM 9917 CE1 PHE B 105 69.952 52.182 −15.166 1.00 37.47 B C ATOM 9919 CZ PHE B 105 68.680 52.719 −15.094 1.00 41.23 B C ATOM 9921 CE2 PHE B 105 68.291 53.412 −13.959 1.00 42.58 B C ATOM 9923 CD2 PHE B 105 69.178 53.564 −12.897 1.00 44.83 B C ATOM 9925 C PHE B 105 72.459 55.200 −12.938 1.00 45.55 B C ATOM 9926 O PHE B 105 72.515 55.272 −14.165 1.00 46.03 B O ATOM 9928 N ASP B 106 72.181 56.251 −12.184 1.00 48.32 B N ATOM 9929 CA ASP B 106 71.949 57.544 −12.816 1.00 50.02 B C ATOM 9931 CB ASP B 106 71.521 58.609 −11.799 1.00 51.66 B C ATOM 9934 CG ASP B 106 70.532 59.608 −12.389 1.00 59.23 B C ATOM 9935 OD1 ASP B 106 70.967 60.722 −12.764 1.00 68.92 B O ATOM 9936 OD2 ASP B 106 69.329 59.265 −12.503 1.00 64.95 B O ATOM 9937 C ASP B 106 73.202 57.974 −13.594 1.00 48.61 B C ATOM 9938 O ASP B 106 73.086 58.477 −14.710 1.00 49.31 B O ATOM 9940 N ALA B 107 74.384 57.740 −13.017 1.00 46.79 B N ATOM 9941 CA ALA B 107 75.666 58.062 −13.663 1.00 45.20 B C ATOM 9943 CB ALA B 107 76.843 57.556 −12.813 1.00 45.79 B C ATOM 9947 C ALA B 107 75.773 57.487 −15.070 1.00 44.20 B C ATOM 9948 O ALA B 107 76.122 58.209 −16.012 1.00 43.29 B O ATOM 9950 N VAL B 108 75.468 56.193 −15.214 1.00 42.78 B N ATOM 9951 CA VAL B 108 75.678 55.509 −16.490 1.00 41.56 B C ATOM 9953 CB VAL B 108 75.580 53.961 −16.398 1.00 42.67 B C ATOM 9955 CG1 VAL B 108 76.575 53.424 −15.362 1.00 47.74 B C ATOM 9959 CG2 VAL B 108 74.146 53.506 −16.103 1.00 37.79 B C ATOM 9963 C VAL B 108 74.736 56.019 −17.565 1.00 40.56 B C ATOM 9964 O VAL B 108 75.140 56.108 −18.716 1.00 41.01 B O ATOM 9966 N THR B 109 73.502 56.372 −17.201 1.00 40.25 B N ATOM 9967 CA THR B 109 72.547 56.895 −18.191 1.00 41.97 B C ATOM 9969 CB THR B 109 71.113 57.091 −17.604 1.00 41.78 B C ATOM 9971 OG1 THR B 109 71.096 58.187 −16.682 1.00 41.41 B O ATOM 9973 CG2 THR B 109 70.628 55.818 −16.897 1.00 40.99 B C ATOM 9977 C THR B 109 73.024 58.197 −18.874 1.00 43.11 B C ATOM 9978 O THR B 109 72.439 58.614 −19.887 1.00 42.41 B O ATOM 9980 N LYS B 110 74.077 58.819 −18.328 1.00 44.55 B N ATOM 9981 CA LYS B 110 74.712 60.008 −18.934 1.00 46.75 B C ATOM 9983 CB LYS B 110 75.089 61.044 −17.862 1.00 47.58 B C ATOM 9986 CG LYS B 110 74.109 61.209 −16.687 1.00 52.76 B C ATOM 9989 CD LYS B 110 72.754 61.764 −17.101 1.00 59.40 B C ATOM 9992 CE LYS B 110 71.958 62.222 −15.878 1.00 63.05 B C ATOM 9995 NZ LYS B 110 70.552 62.553 −16.225 1.00 62.78 B N ATOM 9999 C LYS B 110 75.976 59.657 −19.743 1.00 46.76 B C ATOM 10000 O LYS B 110 76.282 60.317 −20.748 1.00 47.35 B O ATOM 10002 N THR B 111 76.697 58.619 −19.304 1.00 46.07 B N ATOM 10003 CA THR B 111 77.998 58.251 −19.878 1.00 44.96 B C ATOM 10005 CB THR B 111 79.002 57.862 −18.753 1.00 46.02 B C ATOM 10007 OG1 THR B 111 78.445 56.851 −17.896 1.00 46.80 B O ATOM 10009 CG2 THR B 111 79.355 59.091 −17.907 1.00 48.57 B C ATOM 10013 C THR B 111 77.980 57.145 −20.961 1.00 43.55 B C ATOM 10014 O THR B 111 78.579 57.326 −22.031 1.00 43.45 B O ATOM 10016 N SER B 112 77.288 56.026 −20.695 1.00 40.85 B N ATOM 10017 CA SER B 112 77.475 54.771 −21.460 1.00 38.21 B C ATOM 10019 CB SER B 112 78.367 53.817 −20.654 1.00 38.70 B C ATOM 10022 OG SER B 112 78.963 52.840 −21.489 1.00 42.04 B O ATOM 10024 C SER B 112 76.191 54.013 −21.850 1.00 35.38 B C ATOM 10025 O SER B 112 75.380 53.635 −20.990 1.00 33.95 B O ATOM 10027 N LEU B 113 76.039 53.751 −23.146 1.00 32.47 B N ATOM 10028 CA LEU B 113 74.920 52.960 −23.647 1.00 30.72 B C ATOM 10030 CB LEU B 113 74.878 52.958 −25.174 1.00 30.16 B C ATOM 10033 CG LEU B 113 73.792 52.095 −25.831 1.00 29.63 B C ATOM 10035 CD1 LEU B 113 72.399 52.493 −25.368 1.00 27.97 B C ATOM 10039 CD2 LEU B 113 73.891 52.182 −27.341 1.00 34.38 B C ATOM 10043 C LEU B 113 75.025 51.529 −23.144 1.00 30.25 B C ATOM 10044 O LEU B 113 74.071 51.011 −22.567 1.00 29.96 B O ATOM 10046 N HIS B 114 76.182 50.901 −23.371 1.00 29.63 B N ATOM 10047 CA HIS B 114 76.423 49.536 −22.917 1.00 29.61 B C ATOM 10049 CB HIS B 114 77.874 49.098 −23.189 1.00 28.64 B C ATOM 10052 CG HIS B 114 78.237 47.786 −22.557 1.00 30.75 B C ATOM 10053 ND1 HIS B 114 77.483 46.642 −22.722 1.00 32.60 B N ATOM 10055 CE1 HIS B 114 78.039 45.648 −22.048 1.00 36.57 B C ATOM 10057 NE2 HIS B 114 79.126 46.105 −21.449 1.00 37.27 B N ATOM 10059 CD2 HIS B 114 79.271 47.439 −21.750 1.00 36.73 B C ATOM 10061 C HIS B 114 76.095 49.445 −21.426 1.00 28.21 B C ATOM 10062 O HIS B 114 75.330 48.587 −21.002 1.00 24.16 B O ATOM 10064 N GLY B 115 76.666 50.363 −20.651 1.00 26.67 B N ATOM 10065 CA GLY B 115 76.454 50.389 −19.215 1.00 25.56 B C ATOM 10068 C GLY B 115 74.993 50.506 −18.845 1.00 25.02 B C ATOM 10069 O GLY B 115 74.544 49.881 −17.891 1.00 25.22 B O ATOM 10071 N THR B 116 74.255 51.327 −19.585 1.00 24.92 B N ATOM 10072 CA THR B 116 72.854 51.580 −19.282 1.00 23.97 B C ATOM 10074 CB THR B 116 72.386 52.889 −19.917 1.00 24.60 B C ATOM 10076 OG1 THR B 116 73.118 53.974 −19.331 1.00 30.58 B O ATOM 10078 CG2 THR B 116 70.907 53.144 −19.699 1.00 21.02 B C ATOM 10082 C THR B 116 72.002 50.387 −19.711 1.00 26.00 B C ATOM 10083 O THR B 116 71.102 49.976 −18.967 1.00 27.03 B O ATOM 10085 N ALA B 117 72.304 49.799 −20.868 1.00 25.43 B N ATOM 10086 CA ALA B 117 71.505 48.662 −21.378 1.00 25.89 B C ATOM 10088 CB ALA B 117 71.933 48.268 −22.811 1.00 24.62 B C ATOM 10092 C ALA B 117 71.643 47.470 −20.448 1.00 24.68 B C ATOM 10093 O ALA B 117 70.652 46.837 −20.047 1.00 24.91 B O ATOM 10095 N LEU B 118 72.883 47.160 −20.117 1.00 23.09 B N ATOM 10096 CA LEU B 118 73.178 46.044 −19.230 1.00 23.36 B C ATOM 10098 CB LEU B 118 74.686 45.887 −19.068 1.00 23.58 B C ATOM 10101 CG LEU B 118 75.181 44.714 −18.231 1.00 26.99 B C ATOM 10103 CD1 LEU B 118 74.478 43.412 −18.671 1.00 21.92 B C ATOM 10107 CD2 LEU B 118 76.708 44.613 −18.322 1.00 19.81 B C ATOM 10111 C LEU B 118 72.521 46.257 −17.880 1.00 22.07 B C ATOM 10112 O LEU B 118 71.777 45.405 −17.412 1.00 21.86 B O ATOM 10114 N SER B 119 72.753 47.417 −17.273 1.00 23.56 B N ATOM 10115 CA SER B 119 72.214 47.677 −15.938 1.00 23.71 B C ATOM 10117 CB SER B 119 72.787 48.959 −15.318 1.00 25.08 B C ATOM 10120 OG SER B 119 72.384 50.147 −15.974 1.00 25.85 B O ATOM 10122 C SER B 119 70.697 47.691 −15.957 1.00 22.91 B C ATOM 10123 O SER B 119 70.050 47.212 −15.017 1.00 23.88 B O ATOM 10125 N PHE B 120 70.124 48.197 −17.036 1.00 21.99 B N ATOM 10126 CA PHE B 120 68.674 48.240 −17.144 1.00 22.07 B C ATOM 10128 CB PHE B 120 68.269 48.927 −18.441 1.00 22.76 B C ATOM 10131 CG PHE B 120 66.792 48.936 −18.703 1.00 23.93 B C ATOM 10132 CD1 PHE B 120 66.012 50.026 −18.329 1.00 24.72 B C ATOM 10134 CE1 PHE B 120 64.651 50.041 −18.588 1.00 21.87 B C ATOM 10136 CZ PHE B 120 64.064 48.965 −19.235 1.00 25.59 B C ATOM 10138 CE2 PHE B 120 64.831 47.875 −19.615 1.00 21.43 B C ATOM 10140 CD2 PHE B 120 66.187 47.870 −19.355 1.00 26.77 B C ATOM 10142 C PHE B 120 68.138 46.820 −17.108 1.00 22.44 B C ATOM 10143 O PHE B 120 67.232 46.510 −16.330 1.00 23.78 B O ATOM 10145 N ARG B 121 68.708 45.967 −17.954 1.00 20.63 B N ATOM 10146 CA ARG B 121 68.315 44.563 −18.023 1.00 22.16 B C ATOM 10148 CB ARG B 121 69.116 43.838 −19.109 1.00 20.34 B C ATOM 10151 CG ARG B 121 68.782 42.387 −19.214 1.00 22.78 B C ATOM 10154 CD ARG B 121 69.278 41.785 −20.511 1.00 23.57 B C ATOM 10157 NE ARG B 121 70.735 41.705 −20.574 1.00 22.85 B N ATOM 10159 CZ ARG B 121 71.486 40.804 −19.954 1.00 21.72 B C ATOM 10160 NH1 ARG B 121 70.943 39.879 −19.173 1.00 27.91 B N ATOM 10163 NH2 ARG B 121 72.797 40.835 −20.117 1.00 22.89 B N ATOM 10166 C ARG B 121 68.467 43.826 −16.691 1.00 20.89 B C ATOM 10167 O ARG B 121 67.536 43.185 −16.244 1.00 22.14 B O ATOM 10169 N LEU B 122 69.634 43.918 −16.075 1.00 19.65 B N ATOM 10170 CA LEU B 122 69.877 43.198 −14.829 1.00 21.62 B C ATOM 10172 CB LEU B 122 71.342 43.312 −14.409 1.00 19.60 B C ATOM 10175 CG LEU B 122 72.377 42.726 −15.362 1.00 20.38 B C ATOM 10177 CD1 LEU B 122 73.745 43.081 −14.843 1.00 20.38 B C ATOM 10181 CD2 LEU B 122 72.217 41.193 −15.508 1.00 15.76 B C ATOM 10185 C LEU B 122 68.947 43.705 −13.710 1.00 22.20 B C ATOM 10186 O LEU B 122 68.419 42.921 −12.921 1.00 22.69 B O ATOM 10188 N LEU B 123 68.712 45.009 −13.681 1.00 23.60 B N ATOM 10189 CA LEU B 123 67.893 45.608 −12.624 1.00 24.18 B C ATOM 10191 CB LEU B 123 67.931 47.130 −12.701 1.00 21.92 B C ATOM 10194 CG LEU B 123 69.156 47.757 −12.041 1.00 22.98 B C ATOM 10196 CD1 LEU B 123 69.363 49.223 −12.487 1.00 19.39 B C ATOM 10200 CD2 LEU B 123 68.981 47.662 −10.548 1.00 20.14 B C ATOM 10204 C LEU B 123 66.466 45.120 −12.738 1.00 23.74 B C ATOM 10205 O LEU B 123 65.855 44.696 −11.753 1.00 21.87 B O ATOM 10207 N ARG B 124 65.947 45.176 −13.951 1.00 23.61 B N ATOM 10208 CA ARG B 124 64.580 44.747 −14.194 1.00 22.51 B C ATOM 10210 CB ARG B 124 64.101 45.189 −15.566 1.00 21.92 B C ATOM 10213 CG ARG B 124 62.624 44.861 −15.768 1.00 23.90 B C ATOM 10216 CD ARG B 124 62.050 45.560 −16.965 1.00 23.86 B C ATOM 10219 NE ARG B 124 61.591 46.926 −16.676 1.00 24.72 B N ATOM 10221 CZ ARG B 124 61.083 47.743 −17.601 1.00 24.21 B C ATOM 10222 NH1 ARG B 124 60.998 47.363 −18.872 1.00 21.36 B N ATOM 10225 NH2 ARG B 124 60.671 48.955 −17.265 1.00 25.66 B N ATOM 10228 C ARG B 124 64.420 43.247 −14.052 1.00 22.28 B C ATOM 10229 O ARG B 124 63.435 42.768 −13.479 1.00 23.53 B O ATOM 10231 N GLN B 125 65.389 42.490 −14.549 1.00 23.20 B N ATOM 10232 CA GLN B 125 65.371 41.051 −14.344 1.00 20.98 B C ATOM 10234 CB GLN B 125 66.693 40.426 −14.832 1.00 22.19 B C ATOM 10237 CG GLN B 125 66.800 38.889 −14.619 1.00 17.52 B C ATOM 10240 CD GLN B 125 68.218 38.364 −14.797 1.00 23.28 B C ATOM 10241 OE1 GLN B 125 69.105 39.069 −15.273 1.00 19.79 B O ATOM 10242 NE2 GLN B 125 68.435 37.121 −14.405 1.00 17.64 B N ATOM 10245 C GLN B 125 65.164 40.777 −12.847 1.00 23.00 B C ATOM 10246 O GLN B 125 64.420 39.865 −12.453 1.00 24.90 B O ATOM 10248 N HIS B 126 65.828 41.561 −12.005 1.00 20.88 B N ATOM 10249 CA HIS B 126 65.780 41.310 −10.576 1.00 22.19 B C ATOM 10251 CB HIS B 126 67.179 41.491 −9.966 1.00 22.02 B C ATOM 10254 CG HIS B 126 68.109 40.381 −10.310 1.00 21.58 B C ATOM 10255 ND1 HIS B 126 68.196 39.230 −9.557 1.00 24.31 B N ATOM 10257 CE1 HIS B 126 69.090 38.425 −10.103 1.00 23.72 B C ATOM 10259 NE2 HIS B 126 69.560 38.997 −11.199 1.00 20.64 B N ATOM 10261 CD2 HIS B 126 68.960 40.218 −11.353 1.00 17.59 B C ATOM 10263 C HIS B 126 64.742 42.137 −9.829 1.00 23.10 B C ATOM 10264 O HIS B 126 64.850 42.311 −8.624 1.00 23.65 B O ATOM 10266 N GLY B 127 63.739 42.655 −10.529 1.00 25.00 B N ATOM 10267 CA GLY B 127 62.577 43.232 −9.849 1.00 24.96 B C ATOM 10270 C GLY B 127 62.665 44.712 −9.523 1.00 27.27 B C ATOM 10271 O GLY B 127 61.701 45.275 −9.007 1.00 31.01 B O ATOM 10273 N PHE B 128 63.798 45.353 −9.818 1.00 27.09 B N ATOM 10274 CA PHE B 128 63.946 46.787 −9.589 1.00 27.86 B C ATOM 10276 CB PHE B 128 65.418 47.218 −9.615 1.00 28.07 B C ATOM 10279 CG PHE B 128 66.208 46.655 −8.482 1.00 28.18 B C ATOM 10280 CD1 PHE B 128 66.303 47.336 −7.294 1.00 28.13 B C ATOM 10282 CE1 PHE B 128 67.003 46.811 −6.249 1.00 33.20 B C ATOM 10284 CZ PHE B 128 67.592 45.571 −6.362 1.00 34.73 B C ATOM 10286 CE2 PHE B 128 67.479 44.871 −7.535 1.00 30.35 B C ATOM 10288 CD2 PHE B 128 66.785 45.409 −8.580 1.00 26.88 B C ATOM 10290 C PHE B 128 63.150 47.567 −10.605 1.00 30.22 B C ATOM 10291 O PHE B 128 62.932 47.122 −11.725 1.00 30.38 B O ATOM 10293 N GLU B 129 62.703 48.739 −10.185 1.00 31.72 B N ATOM 10294 CA GLU B 129 61.883 49.589 −10.999 1.00 32.85 B C ATOM 10296 CB GLU B 129 60.995 50.460 −10.091 1.00 35.17 B C ATOM 10299 CG GLU B 129 59.781 51.091 −10.797 1.00 46.55 B C ATOM 10302 CD GLU B 129 59.293 52.392 −10.153 1.00 59.19 B C ATOM 10303 OE1 GLU B 129 59.590 52.647 −8.963 1.00 62.18 B O ATOM 10304 OE2 GLU B 129 58.598 53.169 −10.850 1.00 66.91 B O ATOM 10305 C GLU B 129 62.833 50.455 −11.828 1.00 30.85 B C ATOM 10306 O GLU B 129 63.634 51.200 −11.283 1.00 34.34 B O ATOM 10308 N VAL B 130 62.773 50.339 −13.140 1.00 28.74 B N ATOM 10309 CA VAL B 130 63.538 51.222 −14.013 1.00 27.95 B C ATOM 10311 CB VAL B 130 64.783 50.533 −14.591 1.00 28.89 B C ATOM 10313 CG1 VAL B 130 65.800 50.323 −13.491 1.00 29.52 B C ATOM 10317 CG2 VAL B 130 64.422 49.201 −15.242 1.00 25.33 B C ATOM 10321 C VAL B 130 62.647 51.707 −15.142 1.00 27.27 B C ATOM 10322 O VAL B 130 61.695 51.033 −15.506 1.00 26.56 B O ATOM 10324 N SER B 131 62.969 52.872 −15.692 1.00 27.05 B N ATOM 10325 CA SER B 131 62.140 53.510 −16.713 1.00 27.56 B C ATOM 10327 CB SER B 131 61.864 54.978 −16.339 1.00 29.10 B C ATOM 10330 OG SER B 131 61.318 55.713 −17.434 1.00 34.05 B O ATOM 10332 C SER B 131 62.871 53.470 −18.031 1.00 26.59 B C ATOM 10333 O SER B 131 64.091 53.530 −18.056 1.00 27.34 B O ATOM 10335 N GLN B 132 62.125 53.379 −19.127 1.00 26.19 B N ATOM 10336 CA GLN B 132 62.718 53.487 −20.450 1.00 26.48 B C ATOM 10338 CB GLN B 132 61.660 53.267 −21.528 1.00 26.03 B C ATOM 10341 CG GLN B 132 60.477 54.223 −21.463 1.00 26.99 B C ATOM 10344 CD GLN B 132 59.623 54.191 −22.711 1.00 29.29 B C ATOM 10345 OE1 GLN B 132 59.822 53.355 −23.602 1.00 27.92 B O ATOM 10346 NE2 GLN B 132 58.662 55.110 −22.787 1.00 28.13 B N ATOM 10349 C GLN B 132 63.404 54.840 −20.664 1.00 28.30 B C ATOM 10350 O GLN B 132 64.219 54.978 −21.568 1.00 29.48 B O ATOM 10352 N GLU B 133 63.073 55.840 −19.846 1.00 30.19 B N ATOM 10353 CA GLU B 133 63.686 57.179 −19.974 1.00 32.53 B C ATOM 10355 CB GLU B 133 62.976 58.238 −19.113 1.00 33.08 B C ATOM 10358 CG GLU B 133 61.500 58.466 −19.448 1.00 38.45 B C ATOM 10361 CD GLU B 133 61.264 59.001 −20.854 1.00 45.49 B C ATOM 10362 OE1 GLU B 133 62.178 59.632 −21.439 1.00 49.73 B O ATOM 10363 OE2 GLU B 133 60.144 58.798 −21.376 1.00 46.47 B O ATOM 10364 C GLU B 133 65.155 57.140 −19.609 1.00 31.46 B C ATOM 10365 O GLU B 133 65.884 58.069 −19.912 1.00 32.50 B O ATOM 10367 N ALA B 134 65.584 56.061 −18.964 1.00 30.90 B N ATOM 10368 CA ALA B 134 67.002 55.760 −18.824 1.00 30.86 B C ATOM 10370 CB ALA B 134 67.185 54.385 −18.224 1.00 28.22 B C ATOM 10374 C ALA B 134 67.723 55.849 −20.170 1.00 31.89 B C ATOM 10375 O ALA B 134 68.913 56.107 −20.222 1.00 34.24 B O ATOM 10377 N PHE B 135 66.997 55.657 −21.261 1.00 33.61 B N ATOM 10378 CA PHE B 135 67.597 55.727 −22.588 1.00 34.02 B C ATOM 10380 CB PHE B 135 67.014 54.608 −23.456 1.00 32.07 B C ATOM 10383 CG PHE B 135 67.399 53.261 −22.980 1.00 28.15 B C ATOM 10384 CD1 PHE B 135 66.564 52.535 −22.159 1.00 26.04 B C ATOM 10386 CE1 PHE B 135 66.955 51.280 −21.677 1.00 24.62 B C ATOM 10388 CZ PHE B 135 68.188 50.768 −22.013 1.00 27.19 B C ATOM 10390 CE2 PHE B 135 69.039 51.497 −22.821 1.00 28.77 B C ATOM 10392 CD2 PHE B 135 68.648 52.740 −23.294 1.00 30.81 B C ATOM 10394 C PHE B 135 67.454 57.082 −23.281 1.00 36.30 B C ATOM 10395 O PHE B 135 67.929 57.245 −24.414 1.00 37.39 B O ATOM 10397 N SER B 136 66.840 58.058 −22.611 1.00 37.55 B N ATOM 10398 CA SER B 136 66.566 59.356 −23.244 1.00 38.94 B C ATOM 10400 CB SER B 136 65.767 60.282 −22.305 1.00 39.41 B C ATOM 10403 OG SER B 136 66.461 60.527 −21.086 1.00 40.01 B O ATOM 10405 C SER B 136 67.848 60.047 −23.724 1.00 39.27 B C ATOM 10406 O SER B 136 67.839 60.721 −24.753 1.00 41.19 B O ATOM 10408 N GLY B 137 68.949 59.847 −23.010 1.00 38.96 B N ATOM 10409 CA GLY B 137 70.199 60.526 −23.333 1.00 39.72 B C ATOM 10412 C GLY B 137 70.897 60.111 −24.622 1.00 39.94 B C ATOM 10413 O GLY B 137 71.863 60.761 −25.027 1.00 40.11 B O ATOM 10415 N PHE B 138 70.432 59.038 −25.265 1.00 40.41 B N ATOM 10416 CA PHE B 138 71.074 58.516 −26.490 1.00 41.42 B C ATOM 10418 CB PHE B 138 71.367 57.019 −26.332 1.00 40.22 B C ATOM 10421 CG PHE B 138 72.080 56.695 −25.064 1.00 37.60 B C ATOM 10422 CD1 PHE B 138 73.441 56.898 −24.959 1.00 35.26 B C ATOM 10424 CE1 PHE B 138 74.103 56.628 −23.776 1.00 35.62 B C ATOM 10426 CZ PHE B 138 73.400 56.170 −22.682 1.00 34.61 B C ATOM 10428 CE2 PHE B 138 72.035 55.974 −22.773 1.00 32.75 B C ATOM 10430 CD2 PHE B 138 71.383 56.235 −23.955 1.00 35.81 B C ATOM 10432 C PHE B 138 70.254 58.760 −27.758 1.00 43.98 B C ATOM 10433 O PHE B 138 70.642 58.317 −28.843 1.00 43.19 B O ATOM 10435 N LYS B 139 69.128 59.460 −27.609 1.00 47.54 B N ATOM 10436 CA LYS B 139 68.279 59.824 −28.734 1.00 51.04 B C ATOM 10438 CB LYS B 139 66.799 59.812 −28.322 1.00 51.46 B C ATOM 10441 CG LYS B 139 66.192 58.391 −28.258 1.00 55.89 B C ATOM 10444 CD LYS B 139 64.883 58.314 −27.450 1.00 59.90 B C ATOM 10447 CE LYS B 139 63.667 58.845 −28.219 1.00 63.07 B C ATOM 10450 NZ LYS B 139 63.073 57.860 −29.172 1.00 58.78 B N ATOM 10454 C LYS B 139 68.699 61.198 −29.255 1.00 53.29 B C ATOM 10455 O LYS B 139 68.986 62.106 −28.470 1.00 54.74 B O ATOM 10457 N ASP B 140 68.743 61.339 −30.579 1.00 55.19 B N ATOM 10458 CA ASP B 140 69.183 62.580 −31.216 1.00 56.63 B C ATOM 10460 CB ASP B 140 69.663 62.312 −32.662 1.00 55.93 B C ATOM 10463 CG ASP B 140 68.528 61.932 −33.627 1.00 54.78 B C ATOM 10464 OD1 ASP B 140 67.331 62.035 −33.273 1.00 48.15 B O ATOM 10465 OD2 ASP B 140 68.847 61.518 −34.763 1.00 51.45 B O ATOM 10466 C ASP B 140 68.090 63.656 −31.172 1.00 59.23 B C ATOM 10467 O ASP B 140 67.021 63.456 −30.576 1.00 59.10 B O ATOM 10469 N GLN B 141 68.385 64.794 −31.803 1.00 62.19 B N ATOM 10470 CA GLN B 141 67.447 65.918 −31.951 1.00 63.69 B C ATOM 10472 CB GLN B 141 67.947 66.889 −33.034 1.00 64.14 B C ATOM 10475 CG GLN B 141 69.332 67.484 −32.792 1.00 67.32 B C ATOM 10478 CD GLN B 141 69.331 68.608 −31.775 1.00 70.44 B C ATOM 10479 OE1 GLN B 141 68.722 68.506 −30.710 1.00 70.76 B O ATOM 10480 NE2 GLN B 141 70.032 69.686 −32.097 1.00 68.92 B N ATOM 10483 C GLN B 141 66.032 65.451 −32.314 1.00 63.72 B C ATOM 10484 O GLN B 141 65.086 65.649 −31.544 1.00 63.99 B O ATOM 10486 N ASN B 142 65.912 64.804 −33.473 1.00 63.20 B N ATOM 10487 CA ASN B 142 64.622 64.348 −33.997 1.00 62.48 B C ATOM 10489 CB ASN B 142 64.795 63.752 −35.399 1.00 62.80 B C ATOM 10492 CG ASN B 142 65.133 64.801 −36.442 1.00 64.18 B C ATOM 10493 OD1 ASN B 142 64.277 65.195 −37.234 1.00 64.38 B O ATOM 10494 ND2 ASN B 142 66.381 65.261 −36.446 1.00 61.04 B N ATOM 10497 C ASN B 142 63.913 63.330 −33.100 1.00 61.50 B C ATOM 10498 O ASN B 142 62.686 63.236 −33.128 1.00 61.52 B O ATOM 10500 N GLY B 143 64.685 62.579 −32.311 1.00 59.99 B N ATOM 10501 CA GLY B 143 64.141 61.554 −31.415 1.00 58.60 B C ATOM 10504 C GLY B 143 64.432 60.122 −31.846 1.00 57.01 B C ATOM 10505 O GLY B 143 63.800 59.186 −31.353 1.00 57.12 B O ATOM 10507 N ASN B 144 65.374 59.963 −32.778 1.00 54.93 B N ATOM 10508 CA ASN B 144 65.892 58.658 −33.197 1.00 52.65 B C ATOM 10510 CB ASN B 144 66.171 58.636 −34.709 1.00 52.20 B C ATOM 10513 CG ASN B 144 64.960 59.056 −35.545 1.00 55.56 B C ATOM 10514 OD1 ASN B 144 64.720 60.251 −35.772 1.00 57.00 B O ATOM 10515 ND2 ASN B 144 64.208 58.073 −36.026 1.00 53.61 B N ATOM 10518 C ASN B 144 67.189 58.393 −32.442 1.00 49.76 B C ATOM 10519 O ASN B 144 67.842 59.331 −32.005 1.00 48.69 B O ATOM 10521 N PHE B 145 67.569 57.126 −32.281 1.00 47.64 B N ATOM 10522 CA PHE B 145 68.855 56.807 −31.638 1.00 44.61 B C ATOM 10524 CB PHE B 145 69.028 55.293 −31.433 1.00 43.24 B C ATOM 10527 CG PHE B 145 68.385 54.778 −30.171 1.00 37.63 B C ATOM 10528 CD1 PHE B 145 67.113 54.240 −30.192 1.00 30.84 B C ATOM 10530 CE1 PHE B 145 66.516 53.777 −29.038 1.00 32.98 B C ATOM 10532 CZ PHE B 145 67.188 53.849 −27.839 1.00 35.80 B C ATOM 10534 CE2 PHE B 145 68.462 54.383 −27.796 1.00 36.24 B C ATOM 10536 CD2 PHE B 145 69.052 54.851 −28.958 1.00 35.52 B C ATOM 10538 C PHE B 145 70.014 57.381 −32.452 1.00 44.54 B C ATOM 10539 O PHE B 145 69.957 57.418 −33.679 1.00 43.23 B O ATOM 10541 N LEU B 146 71.051 57.846 −31.761 1.00 45.81 B N ATOM 10542 CA LEU B 146 72.210 58.429 −32.429 1.00 47.80 B C ATOM 10544 CB LEU B 146 73.211 58.969 −31.402 1.00 48.75 B C ATOM 10547 CG LEU B 146 72.777 60.256 −30.682 1.00 50.65 B C ATOM 10549 CD1 LEU B 146 73.588 60.481 −29.409 1.00 52.76 B C ATOM 10553 CD2 LEU B 146 72.894 61.455 −31.605 1.00 50.35 B C ATOM 10557 C LEU B 146 72.860 57.390 −33.344 1.00 48.09 B C ATOM 10558 O LEU B 146 73.014 56.241 −32.960 1.00 47.53 B O ATOM 10560 N GLU B 147 73.217 57.803 −34.559 1.00 49.06 B N ATOM 10561 CA GLU B 147 73.758 56.896 −35.582 1.00 49.97 B C ATOM 10563 CB GLU B 147 73.868 57.627 −36.934 1.00 51.58 B C ATOM 10566 CG GLU B 147 74.260 56.747 −38.147 1.00 56.44 B C ATOM 10569 CD GLU B 147 73.083 55.980 −38.761 1.00 62.69 B C ATOM 10570 OE1 GLU B 147 71.979 56.554 −38.876 1.00 64.99 B O ATOM 10571 OE2 GLU B 147 73.267 54.806 −39.153 1.00 66.36 B O ATOM 10572 C GLU B 147 75.132 56.348 −35.201 1.00 49.04 B C ATOM 10573 O GLU B 147 75.434 55.185 −35.479 1.00 47.66 B O ATOM 10575 N ASN B 148 75.961 57.187 −34.579 1.00 48.87 B N ATOM 10576 CA ASN B 148 77.347 56.814 −34.262 1.00 49.90 B C ATOM 10578 CB ASN B 148 78.202 58.067 −33.992 1.00 51.02 B C ATOM 10581 CG ASN B 148 78.031 58.610 −32.576 1.00 56.07 B C ATOM 10582 OD1 ASN B 148 78.936 58.492 −31.742 1.00 61.26 B O ATOM 10583 ND2 ASN B 148 76.868 59.198 −32.297 1.00 58.99 B N ATOM 10586 C ASN B 148 77.497 55.801 −33.110 1.00 48.73 B C ATOM 10587 O ASN B 148 78.611 55.402 −32.776 1.00 49.75 B O ATOM 10589 N LEU B 149 76.382 55.390 −32.507 1.00 47.68 B N ATOM 10590 CA LEU B 149 76.389 54.305 −31.515 1.00 46.24 B C ATOM 10592 CB LEU B 149 75.105 54.326 −30.675 1.00 44.68 B C ATOM 10595 CG LEU B 149 74.933 55.554 −29.764 1.00 43.56 B C ATOM 10597 CD1 LEU B 149 73.479 55.709 −29.326 1.00 39.02 B C ATOM 10601 CD2 LEU B 149 75.853 55.508 −28.553 1.00 40.99 B C ATOM 10605 C LEU B 149 76.588 52.934 −32.184 1.00 45.14 B C ATOM 10606 O LEU B 149 77.087 52.003 −31.546 1.00 44.56 B O ATOM 10608 N LYS B 150 76.239 52.828 −33.470 1.00 43.79 B N ATOM 10609 CA LYS B 150 76.438 51.593 −34.246 1.00 43.54 B C ATOM 10611 CB LYS B 150 75.933 51.764 −35.682 1.00 43.61 B C ATOM 10614 CG LYS B 150 76.894 52.553 −36.587 1.00 46.08 B C ATOM 10617 CD LYS B 150 76.268 52.898 −37.924 1.00 46.55 B C ATOM 10620 CE LYS B 150 77.268 53.562 −38.861 1.00 44.81 B C ATOM 10623 NZ LYS B 150 76.697 53.648 −40.228 1.00 43.17 B N ATOM 10627 C LYS B 150 77.893 51.098 −34.291 1.00 43.90 B C ATOM 10628 O LYS B 150 78.127 49.952 −34.663 1.00 43.76 B O ATOM 10630 N GLU B 151 78.854 51.963 −33.953 1.00 44.36 B N ATOM 10631 CA AGLU B 151 80.275 51.600 −33.889 0.50 45.03 B C ATOM 10632 CA BGLU B 151 80.259 51.556 −33.922 0.50 44.55 B C ATOM 10635 CB AGLU B 151 81.158 52.860 −33.903 0.50 45.31 B C ATOM 10636 CB BGLU B 151 81.192 52.765 −34.101 0.50 44.49 B C ATOM 10641 CG AGLU B 151 81.067 53.700 −35.176 0.50 46.10 B C ATOM 10642 CG BGLU B 151 80.988 53.561 −35.408 0.50 42.68 B C ATOM 10647 CD AGLU B 151 81.927 54.953 −35.116 0.50 46.35 B C ATOM 10648 CD BGLU B 151 81.246 52.747 −36.675 0.50 39.43 B C ATOM 10649 OE1 AGLU B 151 82.923 54.965 −34.361 0.50 46.87 B O ATOM 10650 OE1 BGLU B 151 82.082 51.820 −36.641 0.50 33.96 B O ATOM 10651 OE2 AGLU B 151 81.610 55.927 −35.830 0.50 47.69 B O ATOM 10652 OE2 BGLU B 151 80.611 53.048 −37.711 0.50 33.24 B O ATOM 10653 C GLU B 151 80.593 50.796 −32.629 1.00 44.92 B C ATOM 10654 O GLU B 151 81.544 50.008 −32.603 1.00 45.51 B O ATOM 10656 N ASP B 152 79.806 51.022 −31.573 1.00 43.91 B N ATOM 10657 CA ASP B 152 79.998 50.341 −30.286 1.00 43.25 B C ATOM 10659 CB ASP B 152 79.682 51.305 −29.129 1.00 42.94 B C ATOM 10662 CG ASP B 152 80.049 50.733 −27.762 1.00 45.23 B C ATOM 10663 OD1 ASP B 152 80.532 49.581 −27.686 1.00 44.55 B O ATOM 10664 OD2 ASP B 152 79.861 51.449 −26.754 1.00 46.70 B O ATOM 10665 C ASP B 152 79.118 49.076 −30.217 1.00 42.56 B C ATOM 10666 O ASP B 152 78.040 49.079 −29.619 1.00 42.14 B O ATOM 10668 N ILE B 153 79.596 47.994 −30.826 1.00 41.74 B N ATOM 10669 CA ILE B 153 78.793 46.777 −31.016 1.00 40.19 B C ATOM 10671 CB ILE B 153 79.541 45.753 −31.887 1.00 41.10 B C ATOM 10673 CG1 ILE B 153 79.823 46.346 −33.276 1.00 43.65 B C ATOM 10676 CD1 ILE B 153 81.312 46.361 −33.649 1.00 51.03 B C ATOM 10680 CG2 ILE B 153 78.717 44.468 −32.025 1.00 37.99 B C ATOM 10684 C ILE B 153 78.407 46.112 −29.702 1.00 39.38 B C ATOM 10685 O ILE B 153 77.333 45.532 −29.578 1.00 39.13 B O ATOM 10687 N LYS B 154 79.306 46.185 −28.732 1.00 38.79 B N ATOM 10688 CA LYS B 154 79.039 45.739 −27.379 1.00 38.18 B C ATOM 10690 CB LYS B 154 80.232 46.100 −26.488 1.00 40.20 B C ATOM 10693 CG LYS B 154 80.401 45.276 −25.243 1.00 45.47 B C ATOM 10696 CD LYS B 154 81.444 45.920 −24.337 1.00 55.39 B C ATOM 10699 CE LYS B 154 82.112 44.908 −23.420 1.00 61.69 B C ATOM 10702 NZ LYS B 154 83.180 44.159 −24.141 1.00 65.48 B N ATOM 10706 C LYS B 154 77.772 46.418 −26.863 1.00 35.45 B C ATOM 10707 O LYS B 154 76.867 45.753 −26.351 1.00 34.35 B O ATOM 10709 N ALA B 155 77.702 47.740 −27.023 1.00 32.93 B N ATOM 10710 CA ALA B 155 76.556 48.512 −26.536 1.00 30.98 B C ATOM 10712 CB ALA B 155 76.862 50.001 −26.539 1.00 28.88 B C ATOM 10716 C ALA B 155 75.300 48.222 −27.344 1.00 30.46 B C ATOM 10717 O ALA B 155 74.190 48.256 −26.799 1.00 31.94 B O ATOM 10719 N ILE B 156 75.457 47.925 −28.632 1.00 29.25 B N ATOM 10720 CA ILE B 156 74.293 47.587 −29.471 1.00 29.09 B C ATOM 10722 CB ILE B 156 74.595 47.690 −30.966 1.00 28.51 B C ATOM 10724 CG1 ILE B 156 75.094 49.091 −31.310 1.00 31.99 B C ATOM 10727 CD1 ILE B 156 74.186 50.194 −30.831 1.00 34.35 B C ATOM 10731 CG2 ILE B 156 73.331 47.424 −31.791 1.00 32.40 B C ATOM 10735 C ILE B 156 73.710 46.207 −29.149 1.00 27.53 B C ATOM 10736 O ILE B 156 72.504 46.040 −29.207 1.00 26.96 B O ATOM 10738 N LEU B 157 74.557 45.234 −28.806 1.00 26.87 B N ATOM 10739 CA LEU B 157 74.082 43.932 −28.339 1.00 28.36 B C ATOM 10741 CB LEU B 157 75.228 42.972 −28.089 1.00 29.14 B C ATOM 10744 CG LEU B 157 75.829 42.284 −29.298 1.00 33.60 B C ATOM 10746 CD1 LEU B 157 77.039 41.499 −28.814 1.00 34.46 B C ATOM 10750 CD2 LEU B 157 74.802 41.359 −29.938 1.00 34.45 B C ATOM 10754 C LEU B 157 73.345 44.078 −27.029 1.00 27.60 B C ATOM 10755 O LEU B 157 72.273 43.506 −26.850 1.00 26.85 B O ATOM 10757 N SER B 158 73.944 44.835 −26.114 1.00 27.41 B N ATOM 10758 CA SER B 158 73.348 45.048 −24.804 1.00 28.54 B C ATOM 10760 CB SER B 158 74.277 45.838 −23.896 1.00 27.73 B C ATOM 10763 OG SER B 158 75.455 45.098 −23.664 1.00 38.76 B O ATOM 10765 C SER B 158 72.015 45.762 −24.937 1.00 26.50 B C ATOM 10766 O SER B 158 71.080 45.412 −24.253 1.00 24.81 B O ATOM 10768 N LEU B 159 71.927 46.739 −25.835 1.00 25.52 B N ATOM 10769 CA LEU B 159 70.659 47.441 −26.078 1.00 24.28 B C ATOM 10771 CB LEU B 159 70.858 48.603 −27.043 1.00 24.65 B C ATOM 10774 CG LEU B 159 69.626 49.433 −27.397 1.00 24.51 B C ATOM 10776 CD1 LEU B 159 68.956 49.970 −26.131 1.00 18.59 B C ATOM 10780 CD2 LEU B 159 70.046 50.557 −28.350 1.00 23.65 B C ATOM 10784 C LEU B 159 69.624 46.484 −26.647 1.00 23.61 B C ATOM 10785 O LEU B 159 68.469 46.488 −26.226 1.00 25.84 B O ATOM 10787 N TYR B 160 70.046 45.665 −27.602 1.00 21.32 B N ATOM 10788 CA TYR B 160 69.176 44.661 −28.182 1.00 19.66 B C ATOM 10790 CB TYR B 160 69.963 43.869 −29.209 1.00 18.24 B C ATOM 10793 CG TYR B 160 69.268 42.660 −29.777 1.00 17.21 B C ATOM 10794 CD1 TYR B 160 68.354 42.773 −30.807 1.00 23.20 B C ATOM 10796 CE1 TYR B 160 67.735 41.642 −31.345 1.00 27.22 B C ATOM 10798 CZ TYR B 160 68.049 40.398 −30.847 1.00 27.43 B C ATOM 10799 OH TYR B 160 67.454 39.267 −31.356 1.00 42.06 B O ATOM 10801 CE2 TYR B 160 68.952 40.273 −29.823 1.00 29.75 B C ATOM 10803 CD2 TYR B 160 69.558 41.398 −29.300 1.00 27.84 B C ATOM 10805 C TYR B 160 68.611 43.735 −27.102 1.00 21.10 B C ATOM 10806 O TYR B 160 67.392 43.479 −27.061 1.00 20.13 B O ATOM 10808 N GLU B 161 69.491 43.246 −26.223 1.00 22.83 B N ATOM 10809 CA GLU B 161 69.086 42.289 −25.195 1.00 22.44 B C ATOM 10811 CB GLU B 161 70.292 41.754 −24.422 1.00 22.12 B C ATOM 10814 CG GLU B 161 71.263 40.919 −25.261 1.00 25.71 B C ATOM 10817 CD GLU B 161 70.733 39.523 −25.628 1.00 27.66 B C ATOM 10818 OE1 GLU B 161 69.565 39.178 −25.328 1.00 34.19 B O ATOM 10819 OE2 GLU B 161 71.505 38.754 −26.223 1.00 23.37 B O ATOM 10820 C GLU B 161 68.120 42.947 −24.227 1.00 22.70 B C ATOM 10821 O GLU B 161 67.144 42.332 −23.790 1.00 23.48 B O ATOM 10823 N ALA B 162 68.396 44.199 −23.899 1.00 20.82 B N ATOM 10824 CA ALA B 162 67.568 44.936 −22.974 1.00 21.15 B C ATOM 10826 CB ALA B 162 68.202 46.260 −22.655 1.00 18.59 B C ATOM 10830 C ALA B 162 66.170 45.145 −23.528 1.00 22.41 B C ATOM 10831 O ALA B 162 65.197 45.161 −22.765 1.00 24.55 B O ATOM 10833 N SER B 163 66.063 45.300 −24.845 1.00 21.15 B N ATOM 10834 CA SER B 163 64.781 45.630 −25.451 1.00 22.45 B C ATOM 10836 CB SER B 163 64.925 45.885 −26.971 1.00 22.21 B C ATOM 10839 OG SER B 163 65.265 44.708 −27.695 1.00 22.00 B O ATOM 10841 C SER B 163 63.725 44.554 −25.191 1.00 22.67 B C ATOM 10842 O SER B 163 62.529 44.867 −25.088 1.00 22.75 B O ATOM 10844 N PHE B 164 64.149 43.297 −25.057 1.00 22.13 B N ATOM 10845 CA PHE B 164 63.175 42.225 −24.898 1.00 22.96 B C ATOM 10847 CB PHE B 164 63.789 40.856 −25.224 1.00 22.93 B C ATOM 10850 CG PHE B 164 64.027 40.683 −26.692 1.00 22.93 B C ATOM 10851 CD1 PHE B 164 63.027 40.169 −27.515 1.00 24.94 B C ATOM 10853 CE1 PHE B 164 63.205 40.072 −28.886 1.00 20.58 B C ATOM 10855 CZ PHE B 164 64.377 40.516 −29.455 1.00 20.41 B C ATOM 10857 CE2 PHE B 164 65.387 41.073 −28.633 1.00 24.66 B C ATOM 10859 CD2 PHE B 164 65.186 41.171 −27.271 1.00 19.04 B C ATOM 10861 C PHE B 164 62.492 42.257 −23.547 1.00 22.65 B C ATOM 10862 O PHE B 164 61.512 41.539 −23.338 1.00 23.15 B O ATOM 10864 N LEU B 165 62.952 43.122 −22.642 1.00 22.52 B N ATOM 10865 CA LEU B 165 62.341 43.187 −21.315 1.00 21.55 B C ATOM 10867 CB LEU B 165 63.392 43.432 −20.237 1.00 23.26 B C ATOM 10870 CG LEU B 165 64.195 42.197 −19.851 1.00 23.00 B C ATOM 10872 CD1 LEU B 165 65.339 41.953 −20.829 1.00 20.20 B C ATOM 10876 CD2 LEU B 165 64.728 42.347 −18.432 1.00 23.73 B C ATOM 10880 C LEU B 165 61.258 44.228 −21.256 1.00 22.76 B C ATOM 10881 O LEU B 165 60.804 44.591 −20.174 1.00 23.40 B O ATOM 10883 N ALA B 166 60.822 44.692 −22.426 1.00 22.61 B N ATOM 10884 CA ALA B 166 59.900 45.804 −22.517 1.00 23.27 B C ATOM 10886 CB ALA B 166 59.693 46.181 −23.973 1.00 21.35 B C ATOM 10890 C ALA B 166 58.565 45.464 −21.899 1.00 22.57 B C ATOM 10891 O ALA B 166 58.155 44.325 −21.932 1.00 24.73 B O ATOM 10893 N LEU B 167 57.906 46.463 −21.338 1.00 23.68 B N ATOM 10894 CA LEU B 167 56.489 46.397 −21.010 1.00 25.21 B C ATOM 10896 CB LEU B 167 56.234 47.072 −19.671 1.00 25.95 B C ATOM 10899 CG LEU B 167 57.098 46.586 −18.506 1.00 29.63 B C ATOM 10901 CD1 LEU B 167 56.644 47.255 −17.228 1.00 27.25 B C ATOM 10905 CD2 LEU B 167 57.012 45.081 −18.375 1.00 25.26 B C ATOM 10909 C LEU B 167 55.663 47.096 −22.097 1.00 26.22 B C ATOM 10910 O LEU B 167 56.203 47.772 −22.981 1.00 28.50 B O ATOM 10912 N GLU B 168 54.352 46.917 −22.039 1.00 26.78 B N ATOM 10913 CA GLU B 168 53.440 47.650 −22.919 1.00 27.31 B C ATOM 10915 CB GLU B 168 52.004 47.290 −22.578 1.00 28.21 B C ATOM 10918 CG GLU B 168 51.505 46.007 −23.166 1.00 35.50 B C ATOM 10921 CD GLU B 168 49.971 45.971 −23.198 1.00 43.15 B C ATOM 10922 OE1 GLU B 168 49.400 45.294 −22.314 1.00 41.77 B O ATOM 10923 OE2 GLU B 168 49.352 46.633 −24.084 1.00 44.65 B O ATOM 10924 C GLU B 168 53.584 49.172 −22.760 1.00 25.57 B C ATOM 10925 O GLU B 168 53.595 49.675 −21.638 1.00 25.79 B O ATOM 10927 N GLY B 169 53.657 49.887 −23.880 1.00 25.49 B N ATOM 10928 CA GLY B 169 53.772 51.356 −23.887 1.00 24.53 B C ATOM 10931 C GLY B 169 55.226 51.835 −23.860 1.00 25.77 B C ATOM 10932 O GLY B 169 55.504 53.029 −24.003 1.00 25.33 B O ATOM 10934 N GLU B 170 56.170 50.916 −23.681 1.00 24.26 B N ATOM 10935 CA GLU B 170 57.563 51.316 −23.691 1.00 24.47 B C ATOM 10937 CB GLU B 170 58.409 50.390 −22.809 1.00 23.98 B C ATOM 10940 CG GLU B 170 58.085 50.601 −21.322 1.00 27.09 B C ATOM 10943 CD GLU B 170 58.979 49.840 −20.370 1.00 32.50 B C ATOM 10944 OE1 GLU B 170 59.047 50.248 −19.187 1.00 33.97 B O ATOM 10945 OE2 GLU B 170 59.600 48.835 −20.791 1.00 33.76 B O ATOM 10946 C GLU B 170 58.057 51.391 −25.122 1.00 25.33 B C ATOM 10947 O GLU B 170 58.854 50.580 −25.562 1.00 25.77 B O ATOM 10949 N ASN B 171 57.583 52.405 −25.838 1.00 25.86 B N ATOM 10950 CA ASN B 171 57.942 52.584 −27.238 1.00 26.42 B C ATOM 10952 CB ASN B 171 57.206 53.793 −27.826 1.00 26.53 B C ATOM 10955 CG ASN B 171 57.401 55.060 −26.997 1.00 32.07 B C ATOM 10956 OD1 ASN B 171 56.890 55.173 −25.877 1.00 29.89 B O ATOM 10957 ND2 ASN B 171 58.153 56.012 −27.539 1.00 28.86 B N ATOM 10960 C ASN B 171 59.449 52.727 −27.472 1.00 27.85 B C ATOM 10961 O ASN B 171 59.962 52.316 −28.511 1.00 29.62 B O ATOM 10963 N ILE B 172 60.163 53.299 −26.512 1.00 28.75 B N ATOM 10964 CA ILE B 172 61.596 53.523 −26.679 1.00 29.05 B C ATOM 10966 CB ILE B 172 62.175 54.382 −25.549 1.00 29.12 B C ATOM 10968 CG1 ILE B 172 61.608 55.804 −25.644 1.00 31.03 B C ATOM 10971 CD1 ILE B 172 61.983 56.695 −24.488 1.00 32.54 B C ATOM 10975 CG2 ILE B 172 63.686 54.472 −25.651 1.00 28.63 B C ATOM 10979 C ILE B 172 62.337 52.200 −26.804 1.00 30.66 B C ATOM 10980 O ILE B 172 63.244 52.075 −27.629 1.00 32.83 B O ATOM 10982 N LEU B 173 61.922 51.200 −26.029 1.00 30.45 B N ATOM 10983 CA LEU B 173 62.542 49.875 −26.103 1.00 28.89 B C ATOM 10985 CB LEU B 173 62.098 49.006 −24.923 1.00 28.96 B C ATOM 10988 CG LEU B 173 62.869 49.210 −23.615 1.00 28.06 B C ATOM 10990 CD1 LEU B 173 63.107 50.664 −23.324 1.00 28.03 B C ATOM 10994 CD2 LEU B 173 62.101 48.562 −22.474 1.00 28.74 B C ATOM 10998 C LEU B 173 62.221 49.191 −27.433 1.00 28.15 B C ATOM 10999 O LEU B 173 63.094 48.582 −28.049 1.00 29.10 B O ATOM 11001 N ASP B 174 60.976 49.298 −27.878 1.00 27.45 B N ATOM 11002 CA ASP B 174 60.586 48.825 −29.222 1.00 28.78 B C ATOM 11004 CB ASP B 174 59.117 49.152 −29.509 1.00 29.66 B C ATOM 11007 CG ASP B 174 58.140 48.181 −28.843 1.00 36.16 B C ATOM 11008 OD1 ASP B 174 58.535 47.387 −27.960 1.00 45.20 B O ATOM 11009 OD2 ASP B 174 56.954 48.219 −29.219 1.00 44.48 B O ATOM 11010 C ASP B 174 61.439 49.465 −30.314 1.00 28.84 B C ATOM 11011 O ASP B 174 61.879 48.805 −31.254 1.00 30.79 B O ATOM 11013 N GLU B 175 61.660 50.760 −30.193 1.00 29.80 B N ATOM 11014 CA GLU B 175 62.492 51.469 −31.151 1.00 30.39 B C ATOM 11016 CB GLU B 175 62.349 52.977 −30.949 1.00 30.54 B C ATOM 11019 CG GLU B 175 60.948 53.528 −31.292 1.00 35.87 B C ATOM 11022 CD GLU B 175 60.612 54.872 −30.601 1.00 42.68 B C ATOM 11023 OE1 GLU B 175 61.530 55.551 −30.070 1.00 40.27 B O ATOM 11024 OE2 GLU B 175 59.413 55.246 −30.602 1.00 43.14 B O ATOM 11025 C GLU B 175 63.944 51.005 −30.982 1.00 30.18 B C ATOM 11026 O GLU B 175 64.660 50.798 −31.969 1.00 30.45 B O ATOM 11028 N ALA B 176 64.359 50.807 −29.732 1.00 28.90 B N ATOM 11029 CA ALA B 176 65.695 50.272 −29.433 1.00 27.90 B C ATOM 11031 CB ALA B 176 65.829 49.984 −27.974 1.00 26.60 B C ATOM 11035 C ALA B 176 65.973 49.011 −30.228 1.00 27.63 B C ATOM 11036 O ALA B 176 67.037 48.867 −30.823 1.00 27.16 B O ATOM 11038 N LYS B 177 64.992 48.118 −30.253 1.00 27.87 B N ATOM 11039 CA LYS B 177 65.143 46.821 −30.902 1.00 27.75 B C ATOM 11041 CB LYS B 177 63.983 45.879 −30.524 1.00 25.44 B C ATOM 11044 CG LYS B 177 63.931 44.587 −31.332 1.00 27.36 B C ATOM 11047 CD LYS B 177 63.211 43.426 −30.638 1.00 31.71 B C ATOM 11050 CE LYS B 177 61.774 43.731 −30.205 1.00 32.14 B C ATOM 11053 NZ LYS B 177 61.287 42.780 −29.169 1.00 25.79 B N ATOM 11057 C LYS B 177 65.251 46.964 −32.419 1.00 29.31 B C ATOM 11058 O LYS B 177 66.057 46.272 −33.042 1.00 30.76 B O ATOM 11060 N VAL B 178 64.420 47.828 −33.006 1.00 30.40 B N ATOM 11061 CA VAL B 178 64.425 48.056 −34.460 1.00 29.52 B C ATOM 11063 CB VAL B 178 63.367 49.122 −34.909 1.00 29.52 B C ATOM 11065 CG1 VAL B 178 63.644 49.609 −36.351 1.00 27.87 B C ATOM 11069 CG2 VAL B 178 61.941 48.598 −34.790 1.00 27.79 B C ATOM 11073 C VAL B 178 65.797 48.585 −34.819 1.00 30.34 B C ATOM 11074 O VAL B 178 66.452 48.101 −35.752 1.00 31.89 B O ATOM 11076 N PHE B 179 66.229 49.575 −34.047 1.00 30.22 B N ATOM 11077 CA PHE B 179 67.516 50.223 −34.258 1.00 29.99 B C ATOM 11079 CB PHE B 179 67.688 51.372 −33.260 1.00 29.89 B C ATOM 11082 CG PHE B 179 69.056 51.967 −33.262 1.00 29.85 B C ATOM 11083 CD1 PHE B 179 69.476 52.745 −34.322 1.00 30.02 B C ATOM 11085 CE1 PHE B 179 70.743 53.287 −34.335 1.00 30.08 B C ATOM 11087 CZ PHE B 179 71.607 53.063 −33.276 1.00 31.16 B C ATOM 11089 CE2 PHE B 179 71.207 52.288 −32.215 1.00 32.64 B C ATOM 11091 CD2 PHE B 179 69.929 51.735 −32.213 1.00 31.27 B C ATOM 11093 C PHE B 179 68.694 49.251 −34.147 1.00 30.91 B C ATOM 11094 O PHE B 179 69.531 49.183 −35.054 1.00 33.53 B O ATOM 11096 N ALA B 180 68.763 48.502 −33.049 1.00 29.27 B N ATOM 11097 CA ALA B 180 69.898 47.602 −32.831 1.00 28.27 B C ATOM 11099 CB ALA B 180 69.951 47.121 −31.393 1.00 26.03 B C ATOM 11103 C ALA B 180 69.886 46.429 −33.794 1.00 28.76 B C ATOM 11104 O ALA B 180 70.928 46.013 −34.264 1.00 30.14 B O ATOM 11106 N ILE B 181 68.713 45.903 −34.105 1.00 30.72 B N ATOM 11107 CA ILE B 181 68.621 44.841 −35.108 1.00 32.83 B C ATOM 11109 CB ILE B 181 67.160 44.382 −35.331 1.00 32.27 B C ATOM 11111 CG1 ILE B 181 66.724 43.407 −34.235 1.00 37.17 B C ATOM 11114 CD1 ILE B 181 65.238 42.897 −34.385 1.00 36.59 B C ATOM 11118 CG2 ILE B 181 66.995 43.703 −36.694 1.00 34.78 B C ATOM 11122 C ILE B 181 69.217 45.289 −36.452 1.00 34.90 B C ATOM 11123 O ILE B 181 69.973 44.539 −37.078 1.00 35.81 B O ATOM 11125 N SER B 182 68.885 46.501 −36.893 1.00 36.36 B N ATOM 11126 CA SER B 182 69.314 46.952 −38.229 1.00 38.78 B C ATOM 11128 CB SER B 182 68.701 48.315 −38.607 1.00 38.10 B C ATOM 11131 OG SER B 182 69.333 49.382 −37.919 1.00 41.06 B O ATOM 11133 C SER B 182 70.840 46.992 −38.350 1.00 39.40 B C ATOM 11134 O SER B 182 71.385 46.696 −39.407 1.00 40.69 B O ATOM 11136 N HIS B 183 71.532 47.334 −37.269 1.00 40.96 B N ATOM 11137 CA HIS B 183 72.998 47.410 −37.315 1.00 41.22 B C ATOM 11139 CB HIS B 183 73.503 48.563 −36.448 1.00 40.88 B C ATOM 11142 CG HIS B 183 73.160 49.899 −37.014 1.00 46.75 B C ATOM 11143 ND1 HIS B 183 72.264 50.757 −36.415 1.00 50.90 B N ATOM 11145 CE1 HIS B 183 72.134 51.840 −37.161 1.00 54.30 B C ATOM 11147 NE2 HIS B 183 72.896 51.704 −38.231 1.00 53.96 B N ATOM 11149 CD2 HIS B 183 73.543 50.495 −38.167 1.00 48.27 B C ATOM 11151 C HIS B 183 73.703 46.112 −36.955 1.00 40.72 B C ATOM 11152 O HIS B 183 74.900 46.003 −37.173 1.00 42.77 B O ATOM 11154 N LEU B 184 72.973 45.128 −36.432 1.00 39.36 B N ATOM 11155 CA LEU B 184 73.590 43.855 −36.043 1.00 38.20 B C ATOM 11157 CB LEU B 184 72.887 43.260 −34.811 1.00 36.21 B C ATOM 11160 CG LEU B 184 73.193 43.912 −33.457 1.00 33.67 B C ATOM 11162 CD1 LEU B 184 72.210 43.448 −32.429 1.00 23.99 B C ATOM 11166 CD2 LEU B 184 74.618 43.608 −33.002 1.00 27.65 B C ATOM 11170 C LEU B 184 73.628 42.823 −37.179 1.00 40.01 B C ATOM 11171 O LEU B 184 74.596 42.065 −37.301 1.00 37.78 B O ATOM 11173 N LYS B 185 72.590 42.763 −38.006 1.00 43.51 B N ATOM 11174 CA LYS B 185 72.541 41.685 −39.001 1.00 48.61 B C ATOM 11176 CB LYS B 185 71.099 41.321 −39.391 1.00 49.10 B C ATOM 11179 CG LYS B 185 70.449 42.148 −40.488 1.00 55.39 B C ATOM 11182 CD LYS B 185 68.962 41.760 −40.670 1.00 62.71 B C ATOM 11185 CE LYS B 185 68.785 40.320 −41.201 1.00 66.06 B C ATOM 11188 NZ LYS B 185 67.354 39.952 −41.448 1.00 65.27 B N ATOM 11192 C LYS B 185 73.431 41.961 −40.218 1.00 50.99 B C ATOM 11193 O LYS B 185 73.784 41.040 −40.944 1.00 51.11 B O ATOM 11195 N GLU B 186 73.828 43.213 −40.403 1.00 54.84 B N ATOM 11196 CA GLU B 186 74.706 43.569 −41.513 1.00 59.61 B C ATOM 11198 CB GLU B 186 74.519 45.052 −41.895 1.00 60.90 B C ATOM 11201 CG GLU B 186 73.110 45.425 −42.369 1.00 64.87 B C ATOM 11204 CD GLU B 186 72.750 44.835 −43.733 1.00 70.39 B C ATOM 11205 OE1 GLU B 186 73.310 45.292 −44.758 1.00 71.34 B O ATOM 11206 OE2 GLU B 186 71.889 43.925 −43.777 1.00 69.40 B O ATOM 11207 C GLU B 186 76.197 43.293 −41.233 1.00 60.98 B C ATOM 11208 O GLU B 186 77.017 43.423 −42.139 1.00 61.95 B O ATOM 11210 N LEU B 187 76.549 42.907 −40.004 1.00 62.28 B N ATOM 11211 CA LEU B 187 77.964 42.855 −39.581 1.00 62.62 B C ATOM 11213 CB LEU B 187 78.078 42.851 −38.054 1.00 61.51 B C ATOM 11216 CG LEU B 187 77.507 44.076 −37.343 1.00 60.53 B C ATOM 11218 CD1 LEU B 187 77.696 43.951 −35.843 1.00 56.66 B C ATOM 11222 CD2 LEU B 187 78.131 45.375 −37.861 1.00 60.27 B C ATOM 11226 C LEU B 187 78.736 41.662 −40.143 1.00 64.20 B C ATOM 11227 O LEU B 187 78.216 40.546 −40.198 1.00 64.08 B O ATOM 11229 N SER B 188 79.987 41.914 −40.533 1.00 65.99 B N ATOM 11230 CA SER B 188 80.843 40.903 −41.168 1.00 67.23 B C ATOM 11232 CB SER B 188 81.579 41.514 −42.370 1.00 67.61 B C ATOM 11235 OG SER B 188 82.193 40.517 −43.168 1.00 68.97 B O ATOM 11237 C SER B 188 81.862 40.357 −40.172 1.00 67.24 B C ATOM 11238 O SER B 188 82.548 41.136 −39.507 1.00 66.19 B O ATOM 11240 N GLU B 189 81.970 39.026 −40.093 1.00 68.52 B N ATOM 11241 CA GLU B 189 82.944 38.357 −39.206 1.00 70.09 B C ATOM 11243 CB GLU B 189 82.912 36.818 −39.372 1.00 70.61 B C ATOM 11246 CG GLU B 189 84.084 36.079 −38.655 1.00 74.42 B C ATOM 11249 CD GLU B 189 83.884 34.571 −38.451 1.00 78.48 B C ATOM 11250 OE1 GLU B 189 82.846 34.014 −38.868 1.00 78.02 B O ATOM 11251 OE2 GLU B 189 84.790 33.939 −37.857 1.00 81.03 B O ATOM 11252 C GLU B 189 84.366 38.869 −39.429 1.00 70.71 B C ATOM 11253 O GLU B 189 85.214 38.768 −38.538 1.00 69.61 B O ATOM 11255 N GLU B 190 84.619 39.412 −40.617 1.00 71.86 B N ATOM 11256 CA GLU B 190 85.936 39.921 −40.967 1.00 73.09 B C ATOM 11258 CB GLU B 190 86.081 39.953 −42.492 1.00 74.22 B C ATOM 11261 CG GLU B 190 85.947 38.559 −43.117 1.00 77.50 B C ATOM 11264 CD GLU B 190 85.806 38.582 −44.623 1.00 80.99 B C ATOM 11265 OE1 GLU B 190 86.833 38.752 −45.309 1.00 81.25 B O ATOM 11266 OE2 GLU B 190 84.674 38.400 −45.121 1.00 84.29 B O ATOM 11267 C GLU B 190 86.227 41.289 −40.324 1.00 72.73 B C ATOM 11268 O GLU B 190 87.328 41.505 −39.808 1.00 72.35 B O ATOM 11270 N LYS B 191 85.246 42.195 −40.334 1.00 72.21 B N ATOM 11271 CA LYS B 191 85.414 43.512 −39.697 1.00 72.24 B C ATOM 11273 CB LYS B 191 84.208 44.417 −39.967 1.00 73.12 B C ATOM 11276 CG LYS B 191 84.121 44.922 −41.378 1.00 78.07 B C ATOM 11279 CD LYS B 191 82.949 45.868 −41.546 1.00 83.68 B C ATOM 11282 CE LYS B 191 82.589 46.014 −43.012 1.00 85.64 B C ATOM 11285 NZ LYS B 191 81.322 46.764 −43.228 1.00 85.74 B N ATOM 11289 C LYS B 191 85.587 43.362 −38.192 1.00 70.52 B C ATOM 11290 O LYS B 191 86.656 43.635 −37.640 1.00 69.35 B O ATOM 11292 N ILE B 192 84.515 42.917 −37.546 1.00 68.76 B N ATOM 11293 CA ILE B 192 84.498 42.712 −36.102 1.00 67.68 B C ATOM 11295 CB ILE B 192 83.059 42.833 −35.544 1.00 67.45 B C ATOM 11297 CG1 ILE B 192 82.129 41.758 −36.137 1.00 66.91 B C ATOM 11300 CD1 ILE B 192 80.731 41.750 −35.544 1.00 62.95 B C ATOM 11304 CG2 ILE B 192 82.495 44.217 −35.848 1.00 67.23 B C ATOM 11308 C ILE B 192 85.101 41.346 −35.781 1.00 66.59 B C ATOM 11309 O ILE B 192 85.310 40.533 −36.678 1.00 65.89 B O ATOM 11311 N GLY B 193 85.381 41.092 −34.508 1.00 65.99 B N ATOM 11312 CA GLY B 193 85.987 39.820 −34.095 1.00 66.09 B C ATOM 11315 C GLY B 193 85.240 38.558 −34.522 1.00 65.01 B C ATOM 11316 O GLY B 193 84.047 38.599 −34.838 1.00 65.07 B O ATOM 11318 N LYS B 194 85.950 37.431 −34.522 1.00 63.20 B N ATOM 11319 CA LYS B 194 85.349 36.125 −34.810 1.00 61.59 B C ATOM 11321 CB LYS B 194 86.420 35.045 −35.024 1.00 62.81 B C ATOM 11324 CG LYS B 194 87.707 35.553 −35.719 1.00 69.11 B C ATOM 11327 CD LYS B 194 88.577 34.426 −36.265 1.00 73.14 B C ATOM 11330 CE LYS B 194 89.964 34.937 −36.630 1.00 73.97 B C ATOM 11333 NZ LYS B 194 90.701 33.974 −37.486 1.00 72.97 B N ATOM 11337 C LYS B 194 84.449 35.739 −33.642 1.00 58.97 B C ATOM 11338 O LYS B 194 83.352 35.227 −33.848 1.00 58.12 B O ATOM 11340 N GLU B 195 84.916 36.004 −32.419 1.00 56.35 B N ATOM 11341 CA GLU B 195 84.129 35.732 −31.211 1.00 54.87 B C ATOM 11343 CB GLU B 195 84.997 35.779 −29.942 1.00 55.37 B C ATOM 11346 CG GLU B 195 85.305 37.173 −29.405 1.00 59.74 B C ATOM 11349 CD GLU B 195 86.263 37.147 −28.214 1.00 65.81 B C ATOM 11350 OE1 GLU B 195 85.953 37.804 −27.195 1.00 68.11 B O ATOM 11351 OE2 GLU B 195 87.321 36.478 −28.292 1.00 62.87 B O ATOM 11352 C GLU B 195 82.938 36.687 −31.088 1.00 52.05 B C ATOM 11353 O GLU B 195 81.881 36.302 −30.569 1.00 51.42 B O ATOM 11355 N LEU B 196 83.104 37.917 −31.575 1.00 48.06 B N ATOM 11356 CA LEU B 196 82.024 38.902 −31.518 1.00 44.72 B C ATOM 11358 CB LEU B 196 82.556 40.327 −31.685 1.00 44.61 B C ATOM 11361 CG LEU B 196 81.759 41.396 −30.928 1.00 44.98 B C ATOM 11363 CD1 LEU B 196 81.934 41.257 −29.418 1.00 47.04 B C ATOM 11367 CD2 LEU B 196 82.168 42.798 −31.387 1.00 45.98 B C ATOM 11371 C LEU B 196 80.918 38.607 −32.538 1.00 41.82 B C ATOM 11372 O LEU B 196 79.750 38.849 −32.256 1.00 40.86 B O ATOM 11374 N ALA B 197 81.273 38.069 −33.705 1.00 39.07 B N ATOM 11375 CA ALA B 197 80.260 37.639 −34.679 1.00 37.43 B C ATOM 11377 CB ALA B 197 80.898 37.300 −36.021 1.00 36.56 B C ATOM 11381 C ALA B 197 79.487 36.437 −34.146 1.00 36.90 B C ATOM 11382 O ALA B 197 78.300 36.286 −34.411 1.00 39.21 B O ATOM 11384 N GLU B 198 80.166 35.574 −33.404 1.00 36.09 B N ATOM 11385 CA GLU B 198 79.496 34.465 −32.744 1.00 36.69 B C ATOM 11387 CB GLU B 198 80.519 33.469 −32.174 1.00 38.24 B C ATOM 11390 CG GLU B 198 81.044 32.504 −33.263 1.00 49.87 B C ATOM 11393 CD GLU B 198 82.379 31.814 −32.933 1.00 59.13 B C ATOM 11394 OE1 GLU B 198 82.981 32.093 −31.870 1.00 66.73 B O ATOM 11395 OE2 GLU B 198 82.824 30.983 −33.760 1.00 62.01 B O ATOM 11396 C GLU B 198 78.522 34.985 −31.677 1.00 32.99 B C ATOM 11397 O GLU B 198 77.413 34.491 −31.592 1.00 34.75 B O ATOM 11399 N GLN B 199 78.913 36.001 −30.908 1.00 29.51 B N ATOM 11400 CA GLN B 199 77.997 36.612 −29.945 1.00 29.35 B C ATOM 11402 CB GLN B 199 78.656 37.722 −29.115 1.00 30.73 B C ATOM 11405 CG GLN B 199 79.775 37.269 −28.142 1.00 39.02 B C ATOM 11408 CD GLN B 199 79.280 36.756 −26.781 1.00 51.63 B C ATOM 11409 OE1 GLN B 199 78.074 36.694 −26.513 1.00 54.70 B O ATOM 11410 NE2 GLN B 199 80.229 36.385 −25.912 1.00 48.54 B N ATOM 11413 C GLN B 199 76.783 37.171 −30.668 1.00 28.02 B C ATOM 11414 O GLN B 199 75.660 36.876 −30.286 1.00 26.21 B O ATOM 11416 N VAL B 200 77.008 37.933 −31.739 1.00 27.32 B N ATOM 11417 CA VAL B 200 75.911 38.572 −32.485 1.00 27.54 B C ATOM 11419 CB VAL B 200 76.453 39.523 −33.589 1.00 28.36 B C ATOM 11421 CG1 VAL B 200 77.351 40.596 −32.963 1.00 29.95 B C ATOM 11425 CG2 VAL B 200 75.324 40.190 −34.359 1.00 26.02 B C ATOM 11429 C VAL B 200 74.949 37.540 −33.088 1.00 27.67 B C ATOM 11430 O VAL B 200 73.738 37.684 −32.976 1.00 26.60 B O ATOM 11432 N ASN B 201 75.484 36.489 −33.705 1.00 28.51 B N ATOM 11433 CA ASN B 201 74.636 35.429 −34.266 1.00 29.14 B C ATOM 11435 CB ASN B 201 75.477 34.473 −35.110 1.00 29.87 B C ATOM 11438 CG ASN B 201 76.085 35.156 −36.340 1.00 35.29 B C ATOM 11439 OD1 ASN B 201 75.519 36.111 −36.876 1.00 40.73 B O ATOM 11440 ND2 ASN B 201 77.240 34.666 −36.786 1.00 36.68 B N ATOM 11443 C ASN B 201 73.866 34.654 −33.186 1.00 28.87 B C ATOM 11444 O ASN B 201 72.728 34.266 −33.380 1.00 30.14 B O ATOM 11446 N HIS B 202 74.488 34.432 −32.039 1.00 28.36 B N ATOM 11447 CA HIS B 202 73.802 33.791 −30.935 1.00 27.61 B C ATOM 11449 CB HIS B 202 74.777 33.640 −29.779 1.00 28.85 B C ATOM 11452 CG HIS B 202 74.225 32.906 −28.604 1.00 27.09 B C ATOM 11453 ND1 HIS B 202 73.851 31.583 −28.665 1.00 23.27 B N ATOM 11455 CE1 HIS B 202 73.430 31.198 −27.473 1.00 31.18 B C ATOM 11457 NE2 HIS B 202 73.510 32.228 −26.646 1.00 29.63 B N ATOM 11459 CD2 HIS B 202 74.018 33.304 −27.326 1.00 26.11 B C ATOM 11461 C HIS B 202 72.606 34.649 −30.537 1.00 26.71 B C ATOM 11462 O HIS B 202 71.478 34.167 −30.448 1.00 26.81 B O ATOM 11464 N ALA B 203 72.850 35.941 −30.355 1.00 27.12 B N ATOM 11465 CA ALA B 203 71.799 36.880 −29.978 1.00 26.93 B C ATOM 11467 CB ALA B 203 72.402 38.252 −29.671 1.00 25.40 B C ATOM 11471 C ALA B 203 70.689 37.000 −31.026 1.00 28.19 B C ATOM 11472 O ALA B 203 69.521 37.124 −30.667 1.00 32.01 B O ATOM 11474 N LEU B 204 71.041 36.991 −32.309 1.00 27.53 B N ATOM 11475 CA LEU B 204 70.039 37.155 −33.359 1.00 27.75 B C ATOM 11477 CB LEU B 204 70.657 37.643 −34.688 1.00 28.47 B C ATOM 11480 CG LEU B 204 71.244 39.070 −34.727 1.00 28.70 B C ATOM 11482 CD1 LEU B 204 71.765 39.386 −36.107 1.00 29.73 B C ATOM 11486 CD2 LEU B 204 70.227 40.118 −34.324 1.00 26.53 B C ATOM 11490 C LEU B 204 69.259 35.862 −33.570 1.00 28.30 B C ATOM 11491 O LEU B 204 68.130 35.899 −34.012 1.00 29.24 B O ATOM 11493 N GLU B 205 69.849 34.721 −33.240 1.00 28.21 B N ATOM 11494 CA GLU B 205 69.089 33.481 −33.215 1.00 27.87 B C ATOM 11496 CB GLU B 205 70.020 32.319 −32.906 1.00 27.30 B C ATOM 11499 CG GLU B 205 69.340 30.975 −32.757 1.00 31.98 B C ATOM 11502 CD GLU B 205 70.312 29.900 −32.313 1.00 38.53 B C ATOM 11503 OE1 GLU B 205 70.900 30.036 −31.211 1.00 37.57 B O ATOM 11504 OE2 GLU B 205 70.500 28.926 −33.072 1.00 44.27 B O ATOM 11505 C GLU B 205 67.953 33.579 −32.177 1.00 28.31 B C ATOM 11506 O GLU B 205 66.799 33.221 −32.455 1.00 28.82 B O ATOM 11508 N LEU B 206 68.288 34.069 −30.985 1.00 27.57 B N ATOM 11509 CA LEU B 206 67.320 34.184 −29.894 1.00 26.20 B C ATOM 11511 CB LEU B 206 66.913 32.791 −29.389 1.00 24.32 B C ATOM 11514 CG LEU B 206 65.658 32.728 −28.529 1.00 26.26 B C ATOM 11516 CD1 LEU B 206 64.389 33.063 −29.342 1.00 20.27 B C ATOM 11520 CD2 LEU B 206 65.519 31.347 −27.850 1.00 22.33 B C ATOM 11524 C LEU B 206 67.953 34.958 −28.753 1.00 24.67 B C ATOM 11525 O LEU B 206 69.042 34.609 −28.322 1.00 25.77 B O ATOM 11527 N PRO B 207 67.274 35.992 −28.247 1.00 22.87 B N ATOM 11528 CA PRO B 207 67.814 36.834 −27.206 1.00 22.69 B C ATOM 11530 CB PRO B 207 66.802 37.980 −27.138 1.00 24.47 B C ATOM 11533 CG PRO B 207 65.548 37.352 −27.566 1.00 22.66 B C ATOM 11536 CD PRO B 207 65.953 36.470 −28.679 1.00 24.94 B C ATOM 11539 C PRO B 207 67.835 36.135 −25.879 1.00 22.68 B C ATOM 11540 O PRO B 207 67.086 35.181 −25.683 1.00 21.77 B O ATOM 11541 N LEU B 208 68.661 36.645 −24.967 1.00 23.36 B N ATOM 11542 CA LEU B 208 68.863 36.031 −23.652 1.00 22.82 B C ATOM 11544 CB LEU B 208 69.783 36.906 −22.799 1.00 26.09 B C ATOM 11547 CG LEU B 208 71.296 36.760 −22.912 1.00 29.62 B C ATOM 11549 CD1 LEU B 208 71.965 37.877 −22.134 1.00 35.38 B C ATOM 11553 CD2 LEU B 208 71.688 35.403 −22.345 1.00 31.33 B C ATOM 11557 C LEU B 208 67.554 35.893 −22.915 1.00 22.27 B C ATOM 11558 O LEU B 208 67.304 34.901 −22.272 1.00 23.52 B O ATOM 11560 N HIS B 209 66.710 36.912 −23.010 1.00 19.79 B N ATOM 11561 CA HIS B 209 65.496 36.918 −22.232 1.00 19.81 B C ATOM 11563 CB HIS B 209 64.819 38.278 −22.387 1.00 18.57 B C ATOM 11566 CG HIS B 209 63.665 38.491 −21.464 1.00 20.89 B C ATOM 11567 ND1 HIS B 209 63.798 38.455 −20.095 1.00 18.30 B N ATOM 11569 CE1 HIS B 209 62.624 38.687 −19.537 1.00 19.90 B C ATOM 11571 NE2 HIS B 209 61.732 38.865 −20.497 1.00 24.74 B N ATOM 11573 CD2 HIS B 209 62.357 38.745 −21.713 1.00 19.23 B C ATOM 11575 C HIS B 209 64.550 35.775 −22.659 1.00 18.96 B C ATOM 11576 O HIS B 209 63.638 35.417 −21.928 1.00 20.40 B O ATOM 11578 N ARG B 210 64.771 35.214 −23.838 1.00 17.53 B N ATOM 11579 CA ARG B 210 63.921 34.159 −24.339 1.00 21.00 B C ATOM 11581 CB ARG B 210 63.417 34.519 −25.736 1.00 21.58 B C ATOM 11584 CG ARG B 210 62.558 35.776 −25.720 1.00 25.30 B C ATOM 11587 CD ARG B 210 61.972 36.079 −27.098 1.00 26.92 B C ATOM 11590 NE ARG B 210 61.038 37.199 −27.044 1.00 26.04 B N ATOM 11592 CZ ARG B 210 60.373 37.677 −28.089 1.00 25.39 B C ATOM 11593 NH1 ARG B 210 60.529 37.128 −29.286 1.00 28.28 B N ATOM 11596 NH2 ARG B 210 59.530 38.704 −27.933 1.00 26.88 B N ATOM 11599 C ARG B 210 64.564 32.786 −24.362 1.00 21.01 B C ATOM 11600 O ARG B 210 63.852 31.814 −24.500 1.00 22.57 B O ATOM 11602 N ARG B 211 65.881 32.694 −24.190 1.00 21.79 B N ATOM 11603 CA ARG B 211 66.560 31.387 −24.219 1.00 21.96 B C ATOM 11605 CB ARG B 211 68.017 31.568 −24.607 1.00 20.36 B C ATOM 11608 CG ARG B 211 68.659 30.320 −25.118 1.00 25.64 B C ATOM 11611 CD ARG B 211 70.125 30.557 −25.409 1.00 25.18 B C ATOM 11614 NE ARG B 211 70.339 31.518 −26.488 1.00 22.19 B N ATOM 11616 CZ ARG B 211 70.325 31.219 −27.789 1.00 31.36 B C ATOM 11617 NH1 ARG B 211 70.100 29.974 −28.203 1.00 32.36 B N ATOM 11620 NH2 ARG B 211 70.545 32.174 −28.692 1.00 31.10 B N ATOM 11623 C ARG B 211 66.482 30.715 −22.858 1.00 21.08 B C ATOM 11624 O ARG B 211 66.562 31.380 −21.829 1.00 23.84 B O ATOM 11626 N THR B 212 66.332 29.401 −22.841 1.00 21.62 B N ATOM 11627 CA THR B 212 66.258 28.663 −21.584 1.00 22.86 B C ATOM 11629 CB THR B 212 65.883 27.196 −21.796 1.00 24.07 B C ATOM 11631 OG1 THR B 212 66.761 26.625 −22.770 1.00 31.00 B O ATOM 11633 CG2 THR B 212 64.443 27.050 −22.274 1.00 19.45 B C ATOM 11637 C THR B 212 67.628 28.725 −20.923 1.00 23.79 B C ATOM 11638 O THR B 212 68.643 28.997 −21.580 1.00 23.93 B O ATOM 11640 N GLN B 213 67.656 28.454 −19.630 1.00 23.05 B N ATOM 11641 CA GLN B 213 68.850 28.713 −18.832 1.00 21.92 B C ATOM 11643 CB GLN B 213 68.513 28.620 −17.345 1.00 21.12 B C ATOM 11646 CG GLN B 213 69.466 29.407 −16.398 1.00 26.64 B C ATOM 11649 CD GLN B 213 70.578 28.551 −15.863 1.00 26.56 B C ATOM 11650 OE1 GLN B 213 70.991 27.565 −16.490 1.00 26.61 B O ATOM 11651 NE2 GLN B 213 71.079 28.915 −14.701 1.00 20.90 B N ATOM 11654 C GLN B 213 69.985 27.753 −19.202 1.00 20.81 B C ATOM 11655 O GLN B 213 71.121 28.187 −19.439 1.00 20.28 B O ATOM 11657 N ARG B 214 69.690 26.457 −19.252 1.00 20.19 B N ATOM 11658 CA ARG B 214 70.746 25.484 −19.544 1.00 21.47 B C ATOM 11660 CB ARG B 214 70.290 24.041 −19.386 1.00 21.13 B C ATOM 11663 CG ARG B 214 69.953 23.656 −17.970 1.00 21.84 B C ATOM 11666 CD ARG B 214 71.190 23.470 −17.110 1.00 24.31 B C ATOM 11669 NE ARG B 214 71.582 24.706 −16.457 1.00 25.78 B N ATOM 11671 CZ ARG B 214 72.655 24.854 −15.693 1.00 23.08 B C ATOM 11672 NH1 ARG B 214 73.481 23.834 −15.486 1.00 23.99 B N ATOM 11675 NH2 ARG B 214 72.915 26.046 −15.155 1.00 19.12 B N ATOM 11678 C ARG B 214 71.327 25.675 −20.919 1.00 20.24 B C ATOM 11679 O ARG B 214 72.531 25.534 −21.070 1.00 20.21 B O ATOM 11681 N LEU B 215 70.506 26.014 −21.910 1.00 19.38 B N ATOM 11682 CA LEU B 215 71.021 26.177 −23.278 1.00 21.93 B C ATOM 11684 CB LEU B 215 69.896 26.332 −24.294 1.00 23.52 B C ATOM 11687 CG LEU B 215 69.313 25.060 −24.892 1.00 32.95 B C ATOM 11689 CD1 LEU B 215 70.415 24.335 −25.695 1.00 29.05 B C ATOM 11693 CD2 LEU B 215 68.102 25.417 −25.789 1.00 29.82 B C ATOM 11697 C LEU B 215 71.983 27.354 −23.406 1.00 22.32 B C ATOM 11698 O LEU B 215 73.016 27.231 −24.041 1.00 22.96 B O ATOM 11700 N GLU B 216 71.631 28.488 −22.806 1.00 23.34 B N ATOM 11701 CA GLU B 216 72.543 29.621 −22.693 1.00 23.77 B C ATOM 11703 CB GLU B 216 71.860 30.793 −21.958 1.00 24.84 B C ATOM 11706 CG GLU B 216 72.711 32.044 −21.844 1.00 26.26 B C ATOM 11709 CD GLU B 216 73.313 32.494 −23.185 1.00 29.08 B C ATOM 11710 OE1 GLU B 216 72.657 32.349 −24.232 1.00 30.45 B O ATOM 11711 OE2 GLU B 216 74.452 33.006 −23.181 1.00 29.22 B O ATOM 11712 C GLU B 216 73.815 29.224 −21.940 1.00 23.03 B C ATOM 11713 O GLU B 216 74.910 29.595 −22.331 1.00 25.15 B O ATOM 11715 N ALA B 217 73.692 28.461 −20.865 1.00 21.75 B N ATOM 11716 CA ALA B 217 74.889 28.141 −20.110 1.00 21.54 B C ATOM 11718 CB ALA B 217 74.557 27.429 −18.817 1.00 18.56 B C ATOM 11722 C ALA B 217 75.880 27.336 −20.949 1.00 22.53 B C ATOM 11723 O ALA B 217 77.092 27.634 −20.954 1.00 24.18 B O ATOM 11725 N VAL B 218 75.380 26.356 −21.693 1.00 24.24 B N ATOM 11726 CA VAL B 218 76.264 25.447 −22.423 1.00 24.89 B C ATOM 11728 CB VAL B 218 75.544 24.155 −22.910 1.00 26.35 B C ATOM 11730 CG1 VAL B 218 74.605 24.436 −24.089 1.00 24.54 B C ATOM 11734 CG2 VAL B 218 76.595 23.062 −23.278 1.00 27.94 B C ATOM 11738 C VAL B 218 76.947 26.169 −23.569 1.00 24.67 B C ATOM 11739 O VAL B 218 78.083 25.880 −23.877 1.00 26.68 B O ATOM 11741 N TRP B 219 76.260 27.128 −24.179 1.00 25.65 B N ATOM 11742 CA TRP B 219 76.875 27.976 −25.199 1.00 24.72 B C ATOM 11744 CB TRP B 219 75.789 28.722 −25.996 1.00 26.46 B C ATOM 11747 CG TRP B 219 76.344 29.516 −27.131 1.00 27.34 B C ATOM 11748 CD1 TRP B 219 76.444 29.122 −28.431 1.00 29.10 B C ATOM 11750 NE1 TRP B 219 77.032 30.117 −29.184 1.00 26.04 B N ATOM 11752 CE2 TRP B 219 77.329 31.171 −28.366 1.00 26.96 B C ATOM 11753 CD2 TRP B 219 76.916 30.826 −27.063 1.00 22.98 B C ATOM 11754 CE3 TRP B 219 77.110 31.745 −26.030 1.00 29.02 B C ATOM 11756 CZ3 TRP B 219 77.708 32.965 −26.327 1.00 30.21 B C ATOM 11758 CH2 TRP B 219 78.117 33.273 −27.620 1.00 28.87 B C ATOM 11760 CZ2 TRP B 219 77.937 32.390 −28.657 1.00 32.64 B C ATOM 11762 C TRP B 219 77.855 28.978 −24.584 1.00 23.76 B C ATOM 11763 O TRP B 219 78.924 29.224 −25.124 1.00 27.15 B O ATOM 11765 N SER B 220 77.495 29.574 −23.456 1.00 23.73 B N ATOM 11766 CA SER B 220 78.330 30.616 −22.874 1.00 23.51 B C ATOM 11768 CB SER B 220 77.573 31.395 −21.803 1.00 22.98 B C ATOM 11771 OG SER B 220 76.786 32.384 −22.416 1.00 25.03 B O ATOM 11773 C SER B 220 79.606 30.054 −22.286 1.00 24.58 B C ATOM 11774 O SER B 220 80.623 30.723 −22.291 1.00 26.26 B O ATOM 11776 N ILE B 221 79.542 28.837 −21.755 1.00 24.53 B N ATOM 11777 CA ILE B 221 80.726 28.191 −21.221 1.00 25.43 B C ATOM 11779 CB ILE B 221 80.380 26.930 −20.433 1.00 24.62 B C ATOM 11781 CG1 ILE B 221 79.697 27.327 −19.128 1.00 21.02 B C ATOM 11784 CD1 ILE B 221 78.873 26.217 −18.505 1.00 18.22 B C ATOM 11788 CG2 ILE B 221 81.634 26.132 −20.129 1.00 24.19 B C ATOM 11792 C ILE B 221 81.711 27.866 −22.347 1.00 28.11 B C ATOM 11793 O ILE B 221 82.907 28.122 −22.224 1.00 25.44 B O ATOM 11795 N GLU B 222 81.208 27.331 −23.452 1.00 29.17 B N ATOM 11796 CA GLU B 222 82.064 27.117 −24.612 1.00 30.37 B C ATOM 11798 CB GLU B 222 81.305 26.393 −25.728 1.00 31.94 B C ATOM 11801 CG GLU B 222 82.195 25.909 −26.897 1.00 37.68 B C ATOM 11804 CD GLU B 222 83.413 25.100 −26.431 1.00 40.63 B C ATOM 11805 OE1 GLU B 222 83.347 24.445 −25.362 1.00 46.08 B O ATOM 11806 OE2 GLU B 222 84.437 25.133 −27.136 1.00 49.29 B O ATOM 11807 C GLU B 222 82.681 28.425 −25.139 1.00 29.60 B C ATOM 11808 O GLU B 222 83.845 28.445 −25.474 1.00 31.39 B O ATOM 11810 N ALA B 223 81.917 29.511 −25.198 1.00 29.46 B N ATOM 11811 CA ALA B 223 82.460 30.794 −25.669 1.00 27.98 B C ATOM 11813 CB ALA B 223 81.354 31.779 −25.924 1.00 27.66 B C ATOM 11817 C ALA B 223 83.446 31.378 −24.672 1.00 29.38 B C ATOM 11818 O ALA B 223 84.539 31.784 −25.049 1.00 30.35 B O ATOM 11820 N TYR B 224 83.073 31.405 −23.393 1.00 29.56 B N ATOM 11821 CA TYR B 224 83.948 31.970 −22.364 1.00 28.89 B C ATOM 11823 CB TYR B 224 83.281 31.910 −20.991 1.00 27.75 B C ATOM 11826 CG TYR B 224 83.845 32.869 −19.962 1.00 21.93 B C ATOM 11827 CD1 TYR B 224 83.706 34.246 −20.111 1.00 25.72 B C ATOM 11829 CE1 TYR B 224 84.200 35.134 −19.150 1.00 28.65 B C ATOM 11831 CZ TYR B 224 84.823 34.646 −18.019 1.00 26.53 B C ATOM 11832 OH TYR B 224 85.322 35.516 −17.065 1.00 31.14 B O ATOM 11834 CE2 TYR B 224 84.959 33.293 −17.849 1.00 24.43 B C ATOM 11836 CD2 TYR B 224 84.464 32.409 −18.827 1.00 24.32 B C ATOM 11838 C TYR B 224 85.280 31.227 −22.319 1.00 30.12 B C ATOM 11839 O TYR B 224 86.333 31.827 −22.135 1.00 30.99 B O ATOM 11841 N ARG B 225 85.220 29.915 −22.486 1.00 31.92 B N ATOM 11842 CA ARG B 225 86.409 29.069 −22.478 1.00 34.85 B C ATOM 11844 CB ARG B 225 85.991 27.615 −22.733 1.00 34.71 B C ATOM 11847 CG ARG B 225 87.030 26.604 −22.328 1.00 41.35 B C ATOM 11850 CD ARG B 225 86.910 25.349 −23.161 1.00 44.42 B C ATOM 11853 NE ARG B 225 85.793 24.534 −22.728 1.00 29.27 B N ATOM 11855 CZ ARG B 225 85.866 23.584 −21.803 1.00 26.94 B C ATOM 11856 NH1 ARG B 225 87.007 23.300 −21.189 1.00 22.41 B N ATOM 11859 NH2 ARG B 225 84.776 22.892 −21.496 1.00 24.98 B N ATOM 11862 C ARG B 225 87.452 29.515 −23.529 1.00 36.03 B C ATOM 11863 O ARG B 225 88.644 29.365 −23.320 1.00 34.54 B O ATOM 11865 N LYS B 226 86.986 30.054 −24.655 1.00 39.58 B N ATOM 11866 CA LYS B 226 87.860 30.507 −25.732 1.00 41.75 B C ATOM 11868 CB LYS B 226 87.114 30.457 −27.069 1.00 41.97 B C ATOM 11871 CG LYS B 226 86.581 29.085 −27.431 1.00 44.77 B C ATOM 11874 CD LYS B 226 86.073 29.053 −28.870 1.00 49.54 B C ATOM 11877 CE LYS B 226 85.298 27.780 −29.192 1.00 50.36 B C ATOM 11880 NZ LYS B 226 83.891 28.078 −29.559 1.00 51.17 B N ATOM 11884 C LYS B 226 88.421 31.919 −25.534 1.00 43.33 B C ATOM 11885 O LYS B 226 89.259 32.355 −26.324 1.00 43.89 B O ATOM 11887 N LYS B 227 87.962 32.642 −24.514 1.00 45.03 B N ATOM 11888 CA LYS B 227 88.498 33.981 −24.226 1.00 47.42 B C ATOM 11890 CB LYS B 227 87.508 34.828 −23.413 1.00 47.85 B C ATOM 11893 CG LYS B 227 86.288 35.318 −24.172 1.00 50.13 B C ATOM 11896 CD LYS B 227 85.580 36.442 −23.402 1.00 56.73 B C ATOM 11899 CE LYS B 227 84.102 36.545 −23.774 1.00 64.18 B C ATOM 11902 NZ LYS B 227 83.858 36.666 −25.249 1.00 66.49 B N ATOM 11906 C LYS B 227 89.814 33.870 −23.453 1.00 48.79 B C ATOM 11907 O LYS B 227 89.862 33.243 −22.382 1.00 49.31 B O ATOM 11909 N GLU B 228 90.873 34.484 −23.987 1.00 48.99 B N ATOM 11910 CA GLU B 228 92.184 34.472 −23.327 1.00 49.23 B C ATOM 11912 CB GLU B 228 93.265 35.098 −24.220 1.00 50.17 B C ATOM 11915 CG GLU B 228 94.651 35.139 −23.556 1.00 56.84 B C ATOM 11918 CD GLU B 228 95.805 35.113 −24.551 1.00 62.65 B C ATOM 11919 OE1 GLU B 228 95.772 35.883 −25.536 1.00 63.14 B O ATOM 11920 OE2 GLU B 228 96.753 34.324 −24.336 1.00 62.24 B O ATOM 11921 C GLU B 228 92.150 35.184 −21.972 1.00 46.82 B C ATOM 11922 O GLU B 228 92.875 34.808 −21.048 1.00 47.31 B O ATOM 11924 N ASP B 229 91.304 36.202 −21.859 1.00 43.57 B N ATOM 11925 CA ASP B 229 91.168 36.959 −20.621 1.00 42.02 B C ATOM 11927 CB ASP B 229 90.946 38.439 −20.943 1.00 43.47 B C ATOM 11930 CG ASP B 229 89.751 38.661 −21.854 1.00 47.72 B C ATOM 11931 OD1 ASP B 229 89.491 37.784 −22.704 1.00 51.55 B O ATOM 11932 OD2 ASP B 229 89.079 39.704 −21.726 1.00 55.81 B O ATOM 11933 C ASP B 229 90.035 36.448 −19.714 1.00 38.44 B C ATOM 11934 O ASP B 229 89.667 37.131 −18.769 1.00 37.66 B O ATOM 11936 N ALA B 230 89.489 35.261 −19.983 1.00 35.09 B N ATOM 11937 CA ALA B 230 88.432 34.696 −19.131 1.00 33.38 B C ATOM 11939 CB ALA B 230 87.915 33.392 −19.704 1.00 33.10 B C ATOM 11943 C ALA B 230 88.934 34.465 −17.711 1.00 32.12 B C ATOM 11944 O ALA B 230 90.070 34.048 −17.495 1.00 30.75 B O ATOM 11946 N ASN B 231 88.080 34.738 −16.736 1.00 30.68 B N ATOM 11947 CA ASN B 231 88.422 34.453 −15.359 1.00 29.53 B C ATOM 11949 CB ASN B 231 87.456 35.129 −14.388 1.00 29.88 B C ATOM 11952 CG ASN B 231 87.820 34.867 −12.947 1.00 33.58 B C ATOM 11953 OD1 ASN B 231 87.935 33.714 −12.520 1.00 31.88 B O ATOM 11954 ND2 ASN B 231 88.032 35.936 −12.189 1.00 42.97 B N ATOM 11957 C ASN B 231 88.388 32.960 −15.152 1.00 27.93 B C ATOM 11958 O ASN B 231 87.334 32.338 −15.276 1.00 26.52 B O ATOM 11960 N GLN B 232 89.539 32.398 −14.806 1.00 27.85 B N ATOM 11961 CA GLN B 232 89.696 30.945 −14.719 1.00 28.06 B C ATOM 11963 CB GLN B 232 91.178 30.574 −14.669 1.00 27.87 B C ATOM 11966 CG GLN B 232 91.958 30.978 −15.931 1.00 33.14 B C ATOM 11969 CD GLN B 232 91.460 30.284 −17.202 1.00 35.07 B C ATOM 11970 OE1 GLN B 232 91.496 29.059 −17.301 1.00 37.93 B O ATOM 11971 NE2 GLN B 232 91.003 31.069 −18.177 1.00 32.06 B N ATOM 11974 C GLN B 232 88.940 30.326 −13.538 1.00 27.32 B C ATOM 11975 O GLN B 232 88.472 29.175 −13.625 1.00 28.40 B O ATOM 11977 N VAL B 233 88.814 31.081 −12.449 1.00 23.84 B N ATOM 11978 CA VAL B 233 88.047 30.625 −11.305 1.00 23.03 B C ATOM 11980 CB VAL B 233 88.182 31.592 −10.105 1.00 23.26 B C ATOM 11982 CG1 VAL B 233 87.102 31.342 −9.096 1.00 19.84 B C ATOM 11986 CG2 VAL B 233 89.581 31.440 −9.438 1.00 25.03 B C ATOM 11990 C VAL B 233 86.583 30.457 −11.713 1.00 23.81 B C ATOM 11991 O VAL B 233 85.990 29.405 −11.492 1.00 23.11 B O ATOM 11993 N LEU B 234 86.014 31.491 −12.330 1.00 22.26 B N ATOM 11994 CA LEU B 234 84.630 31.454 −12.733 1.00 22.19 B C ATOM 11996 CB LEU B 234 84.219 32.814 −13.267 1.00 22.77 B C ATOM 11999 CG LEU B 234 82.774 33.046 −13.690 1.00 21.02 B C ATOM 12001 CD1 LEU B 234 81.821 32.913 −12.510 1.00 13.82 B C ATOM 12005 CD2 LEU B 234 82.673 34.433 −14.302 1.00 18.88 B C ATOM 12009 C LEU B 234 84.402 30.345 −13.776 1.00 22.30 B C ATOM 12010 O LEU B 234 83.411 29.637 −13.717 1.00 20.57 B O ATOM 12012 N LEU B 235 85.344 30.188 −14.702 1.00 22.73 B N ATOM 12013 CA LEU B 235 85.219 29.215 −15.783 1.00 22.64 B C ATOM 12015 CB LEU B 235 86.431 29.277 −16.707 1.00 23.38 B C ATOM 12018 CG LEU B 235 86.482 28.297 −17.885 1.00 26.34 B C ATOM 12020 CD1 LEU B 235 85.223 28.417 −18.756 1.00 16.79 B C ATOM 12024 CD2 LEU B 235 87.756 28.530 −18.717 1.00 19.46 B C ATOM 12028 C LEU B 235 85.121 27.835 −15.206 1.00 21.21 B C ATOM 12029 O LEU B 235 84.249 27.054 −15.565 1.00 20.49 B O ATOM 12031 N GLU B 236 86.038 27.550 −14.301 1.00 22.20 B N ATOM 12032 CA GLU B 236 86.112 26.249 −13.692 1.00 22.88 B C ATOM 12034 CB GLU B 236 87.348 26.114 −12.787 1.00 22.27 B C ATOM 12037 CG GLU B 236 87.471 24.721 −12.224 1.00 25.07 B C ATOM 12040 CD GLU B 236 88.782 24.458 −11.508 1.00 30.11 B C ATOM 12041 OE1 GLU B 236 89.489 25.432 −11.145 1.00 32.54 B O ATOM 12042 OE2 GLU B 236 89.081 23.254 −11.316 1.00 28.82 B O ATOM 12043 C GLU B 236 84.852 25.988 −12.902 1.00 21.39 B C ATOM 12044 O GLU B 236 84.299 24.885 −12.977 1.00 23.11 B O ATOM 12046 N LEU B 237 84.395 26.989 −12.154 1.00 19.15 B N ATOM 12047 CA LEU B 237 83.205 26.805 −11.340 1.00 17.76 B C ATOM 12049 CB LEU B 237 82.892 28.060 −10.548 1.00 15.89 B C ATOM 12052 CG LEU B 237 81.682 27.946 −9.637 1.00 14.28 B C ATOM 12054 CD1 LEU B 237 81.846 26.791 −8.650 1.00 8.37 B C ATOM 12058 CD2 LEU B 237 81.476 29.262 −8.914 1.00 13.97 B C ATOM 12062 C LEU B 237 82.035 26.434 −12.255 1.00 18.88 B C ATOM 12063 O LEU B 237 81.303 25.467 −11.980 1.00 21.48 B O ATOM 12065 N ALA B 238 81.911 27.163 −13.362 1.00 16.52 B N ATOM 12066 CA ALA B 238 80.791 27.010 −14.287 1.00 18.32 B C ATOM 12068 CB ALA B 238 80.871 28.022 −15.404 1.00 16.15 B C ATOM 12072 C ALA B 238 80.759 25.621 −14.881 1.00 20.18 B C ATOM 12073 O ALA B 238 79.683 25.009 −14.973 1.00 22.18 B O ATOM 12075 N ILE B 239 81.932 25.132 −15.293 1.00 19.80 B N ATOM 12076 CA ILE B 239 82.039 23.792 −15.821 1.00 19.87 B C ATOM 12078 CB ILE B 239 83.461 23.458 −16.279 1.00 20.01 B C ATOM 12080 CG1 ILE B 239 83.800 24.223 −17.567 1.00 21.51 B C ATOM 12083 CD1 ILE B 239 85.250 23.962 −18.074 1.00 19.39 B C ATOM 12087 CG2 ILE B 239 83.601 21.955 −16.508 1.00 13.60 B C ATOM 12091 C ILE B 239 81.589 22.800 −14.757 1.00 21.11 B C ATOM 12092 O ILE B 239 80.781 21.917 −15.030 1.00 22.06 B O ATOM 12094 N LEU B 240 82.090 22.968 −13.543 1.00 21.72 B N ATOM 12095 CA LEU B 240 81.820 22.022 −12.474 1.00 23.21 B C ATOM 12097 CB LEU B 240 82.645 22.326 −11.208 1.00 23.26 B C ATOM 12100 CG LEU B 240 83.815 21.443 −10.789 1.00 32.42 B C ATOM 12102 CD1 LEU B 240 84.539 20.728 −11.964 1.00 33.31 B C ATOM 12106 CD2 LEU B 240 84.799 22.287 −9.940 1.00 30.31 B C ATOM 12110 C LEU B 240 80.353 22.027 −12.106 1.00 21.05 B C ATOM 12111 O LEU B 240 79.753 20.969 −11.972 1.00 23.99 B O ATOM 12113 N ASP B 241 79.800 23.205 −11.876 1.00 20.47 B N ATOM 12114 CA ASP B 241 78.395 23.319 −11.512 1.00 20.64 B C ATOM 12116 CB ASP B 241 78.004 24.779 −11.273 1.00 21.72 B C ATOM 12119 CG ASP B 241 76.721 24.920 −10.461 1.00 25.74 B C ATOM 12120 OD1 ASP B 241 75.606 24.991 −11.048 1.00 24.61 B O ATOM 12121 OD2 ASP B 241 76.829 24.948 −9.231 1.00 20.16 B O ATOM 12122 C ASP B 241 77.513 22.698 −12.610 1.00 20.65 B C ATOM 12123 O ASP B 241 76.609 21.925 −12.306 1.00 20.46 B O ATOM 12125 N TYR B 242 77.816 22.985 −13.876 1.00 20.03 B N ATOM 12126 CA TYR B 242 76.993 22.490 −14.981 1.00 21.97 B C ATOM 12128 CB TYR B 242 77.486 23.024 −16.327 1.00 21.09 B C ATOM 12131 CG TYR B 242 76.593 22.662 −17.515 1.00 21.48 B C ATOM 12132 CD1 TYR B 242 75.662 23.564 −18.022 1.00 20.87 B C ATOM 12134 CE1 TYR B 242 74.844 23.217 −19.112 1.00 23.37 B C ATOM 12136 CZ TYR B 242 74.986 21.976 −19.706 1.00 19.51 B C ATOM 12137 OH TYR B 242 74.216 21.612 −20.777 1.00 27.52 B O ATOM 12139 CE2 TYR B 242 75.914 21.084 −19.226 1.00 19.92 B C ATOM 12141 CD2 TYR B 242 76.702 21.429 −18.138 1.00 21.77 B C ATOM 12143 C TYR B 242 76.922 20.967 −15.033 1.00 22.49 B C ATOM 12144 O TYR B 242 75.836 20.393 −15.206 1.00 22.20 B O ATOM 12146 N ASN B 243 78.082 20.324 −14.937 1.00 22.43 B N ATOM 12147 CA ASN B 243 78.157 18.857 −14.990 1.00 22.60 B C ATOM 12149 CB ASN B 243 79.601 18.375 −15.194 1.00 20.63 B C ATOM 12152 CG ASN B 243 80.153 18.766 −16.560 1.00 25.15 B C ATOM 12153 OD1 ASN B 243 79.389 18.975 −17.507 1.00 28.79 B O ATOM 12154 ND2 ASN B 243 81.478 18.871 −16.670 1.00 18.72 B N ATOM 12157 C ASN B 243 77.546 18.240 −13.741 1.00 20.99 B C ATOM 12158 O ASN B 243 76.966 17.154 −13.795 1.00 22.45 B O ATOM 12160 N MET B 244 77.646 18.942 −12.626 1.00 19.24 B N ATOM 12161 CA MET B 244 76.979 18.480 −11.426 1.00 22.91 B C ATOM 12163 CB MET B 244 77.363 19.339 −10.230 1.00 22.09 B C ATOM 12166 CG MET B 244 76.629 18.976 −8.959 1.00 26.36 B C ATOM 12169 SD MET B 244 76.675 20.330 −7.774 1.00 40.41 B S ATOM 12170 CE MET B 244 75.425 21.413 −8.512 1.00 38.87 B C ATOM 12174 C MET B 244 75.449 18.467 −11.621 1.00 23.24 B C ATOM 12175 O MET B 244 74.793 17.460 −11.333 1.00 24.26 B O ATOM 12177 N ILE B 245 74.898 19.569 −12.120 1.00 22.08 B N ATOM 12178 CA ILE B 245 73.457 19.669 −12.309 1.00 21.64 B C ATOM 12180 CB ILE B 245 73.036 21.093 −12.702 1.00 22.89 B C ATOM 12182 CG1 ILE B 245 73.240 22.044 −11.518 1.00 22.42 B C ATOM 12185 CD1 ILE B 245 72.776 23.512 −11.793 1.00 23.27 B C ATOM 12189 CG2 ILE B 245 71.558 21.129 −13.161 1.00 20.97 B C ATOM 12193 C ILE B 245 73.037 18.640 −13.356 1.00 21.34 B C ATOM 12194 O ILE B 245 72.069 17.912 −13.180 1.00 21.20 B O ATOM 12196 N GLN B 246 73.803 18.526 −14.423 1.00 21.82 B N ATOM 12197 CA GLN B 246 73.522 17.493 −15.396 1.00 22.03 B C ATOM 12199 CB GLN B 246 74.574 17.464 −16.484 1.00 22.15 B C ATOM 12202 CG GLN B 246 74.215 16.563 −17.638 1.00 21.61 B C ATOM 12205 CD GLN B 246 75.271 16.560 −18.695 1.00 21.70 B C ATOM 12206 OE1 GLN B 246 76.364 16.058 −18.472 1.00 32.02 B O ATOM 12207 NE2 GLN B 246 74.962 17.133 −19.861 1.00 24.97 B N ATOM 12210 C GLN B 246 73.417 16.121 −14.743 1.00 24.58 B C ATOM 12211 O GLN B 246 72.529 15.355 −15.097 1.00 24.66 B O ATOM 12213 N SER B 247 74.285 15.797 −13.784 1.00 23.32 B N ATOM 12214 CA SER B 247 74.229 14.455 −13.209 1.00 25.50 B C ATOM 12216 CB SER B 247 75.468 14.111 −12.354 1.00 24.49 B C ATOM 12219 OG SER B 247 75.372 14.688 −11.056 1.00 30.70 B O ATOM 12221 C SER B 247 72.932 14.269 −12.417 1.00 25.70 B C ATOM 12222 O SER B 247 72.401 13.167 −12.346 1.00 26.49 B O ATOM 12224 N VAL B 248 72.412 15.338 −11.833 1.00 25.46 B N ATOM 12225 CA VAL B 248 71.079 15.268 −11.244 1.00 25.37 B C ATOM 12227 CB VAL B 248 70.708 16.577 −10.534 1.00 25.38 B C ATOM 12229 CG1 VAL B 248 69.289 16.493 −9.982 1.00 21.73 B C ATOM 12233 CG2 VAL B 248 71.737 16.887 −9.411 1.00 21.11 B C ATOM 12237 C VAL B 248 70.019 14.910 −12.324 1.00 27.50 B C ATOM 12238 O VAL B 248 69.186 14.022 −12.114 1.00 30.45 B O ATOM 12240 N TYR B 249 70.069 15.575 −13.475 1.00 25.85 B N ATOM 12241 CA TYR B 249 69.129 15.288 −14.571 1.00 26.78 B C ATOM 12243 CB TYR B 249 69.407 16.170 −15.807 1.00 25.46 B C ATOM 12246 CG TYR B 249 69.297 17.684 −15.619 1.00 24.49 B C ATOM 12247 CD1 TYR B 249 68.579 18.237 −14.570 1.00 19.54 B C ATOM 12249 CE1 TYR B 249 68.456 19.592 −14.429 1.00 21.35 B C ATOM 12251 CZ TYR B 249 69.059 20.421 −15.335 1.00 23.71 B C ATOM 12252 OH TYR B 249 68.955 21.768 −15.170 1.00 24.97 B O ATOM 12254 CE2 TYR B 249 69.757 19.909 −16.406 1.00 21.28 B C ATOM 12256 CD2 TYR B 249 69.880 18.553 −16.539 1.00 22.56 B C ATOM 12258 C TYR B 249 69.190 13.819 −15.025 1.00 28.33 B C ATOM 12259 O TYR B 249 68.153 13.182 −15.264 1.00 27.41 B O ATOM 12261 N GLN B 250 70.411 13.317 −15.184 1.00 27.94 B N ATOM 12262 CA GLN B 250 70.647 11.928 −15.547 1.00 28.73 B C ATOM 12264 CB GLN B 250 72.140 11.676 −15.770 1.00 28.24 B C ATOM 12267 CG GLN B 250 72.701 12.430 −16.993 1.00 26.66 B C ATOM 12270 CD GLN B 250 74.230 12.432 −17.049 1.00 30.68 B C ATOM 12271 OE1 GLN B 250 74.890 12.107 −16.073 1.00 28.92 B O ATOM 12272 NE2 GLN B 250 74.792 12.819 −18.196 1.00 27.40 B N ATOM 12275 C GLN B 250 70.044 10.973 −14.505 1.00 29.66 B C ATOM 12276 O GLN B 250 69.393 10.007 −14.868 1.00 30.79 B O ATOM 12278 N ARG B 251 70.179 11.263 −13.219 1.00 30.47 B N ATOM 12279 CA ARG B 251 69.458 10.465 −12.218 1.00 31.78 B C ATOM 12281 CB ARG B 251 69.915 10.799 −10.792 1.00 32.21 B C ATOM 12284 CG ARG B 251 69.243 9.926 −9.703 1.00 39.99 B C ATOM 12287 CD ARG B 251 69.850 10.113 −8.314 1.00 51.23 B C ATOM 12290 NE ARG B 251 70.143 11.526 −8.019 1.00 62.83 B N ATOM 12292 CZ ARG B 251 71.360 12.091 −7.992 1.00 67.84 B C ATOM 12293 NH1 ARG B 251 72.469 11.384 −8.228 1.00 66.43 B N ATOM 12296 NH2 ARG B 251 71.470 13.391 −7.716 1.00 67.17 B N ATOM 12299 C ARG B 251 67.914 10.585 −12.351 1.00 31.19 B C ATOM 12300 O ARG B 251 67.212 9.576 −12.358 1.00 31.09 B O ATOM 12302 N ASP B 252 67.397 11.806 −12.450 1.00 29.49 B N ATOM 12303 CA ASP B 252 65.973 12.026 −12.633 1.00 27.24 B C ATOM 12305 CB ASP B 252 65.686 13.502 −12.947 1.00 28.05 B C ATOM 12308 CG ASP B 252 66.003 14.474 −11.791 1.00 30.79 B C ATOM 12309 OD1 ASP B 252 66.059 14.063 −10.612 1.00 31.73 B O ATOM 12310 OD2 ASP B 252 66.155 15.691 −12.096 1.00 28.66 B O ATOM 12311 C ASP B 252 65.474 11.193 −13.831 1.00 28.33 B C ATOM 12312 O ASP B 252 64.457 10.512 −13.754 1.00 28.67 B O ATOM 12314 N LEU B 253 66.203 11.267 −14.940 1.00 28.59 B N ATOM 12315 CA LEU B 253 65.850 10.580 −16.179 1.00 29.23 B C ATOM 12317 CB LEU B 253 66.735 11.070 −17.332 1.00 26.17 B C ATOM 12320 CG LEU B 253 66.435 10.484 −18.704 1.00 32.56 B C ATOM 12322 CD1 LEU B 253 64.988 10.790 −19.120 1.00 22.29 B C ATOM 12326 CD2 LEU B 253 67.448 10.988 −19.739 1.00 36.23 B C ATOM 12330 C LEU B 253 65.945 9.055 −16.093 1.00 30.46 B C ATOM 12331 O LEU B 253 65.246 8.361 −16.831 1.00 29.74 B O ATOM 12333 N ARG B 254 66.819 8.537 −15.231 1.00 32.61 B N ATOM 12334 CA ARG B 254 66.942 7.083 −15.057 1.00 35.04 B C ATOM 12336 CB ARG B 254 68.241 6.682 −14.330 1.00 36.65 B C ATOM 12339 CG ARG B 254 69.522 6.685 −15.202 1.00 39.59 B C ATOM 12342 CD ARG B 254 70.676 5.892 −14.532 1.00 45.23 B C ATOM 12345 NE ARG B 254 71.001 6.378 −13.184 1.00 43.70 B N ATOM 12347 CZ ARG B 254 71.747 7.452 −12.921 1.00 44.00 B C ATOM 12348 NH1 ARG B 254 72.276 8.181 −13.910 1.00 39.76 B N ATOM 12351 NH2 ARG B 254 71.961 7.807 −11.659 1.00 43.71 B N ATOM 12354 C ARG B 254 65.720 6.574 −14.306 1.00 34.86 B C ATOM 12355 O ARG B 254 65.111 5.593 −14.712 1.00 35.53 B O ATOM 12357 N GLU B 255 65.346 7.291 −13.251 1.00 34.73 B N ATOM 12358 CA GLU B 255 64.149 7.011 −12.450 1.00 37.10 B C ATOM 12360 CB GLU B 255 64.060 8.073 −11.345 1.00 39.63 B C ATOM 12363 CG GLU B 255 63.692 7.589 −9.941 1.00 52.09 B C ATOM 12366 CD GLU B 255 64.217 8.541 −8.844 1.00 59.96 B C ATOM 12367 OE1 GLU B 255 65.456 8.703 −8.728 1.00 62.20 B O ATOM 12368 OE2 GLU B 255 63.393 9.120 −8.103 1.00 63.44 B O ATOM 12369 C GLU B 255 62.851 7.043 −13.298 1.00 37.49 B C ATOM 12370 O GLU B 255 61.983 6.172 −13.179 1.00 38.24 B O ATOM 12372 N THR B 256 62.726 8.066 −14.139 1.00 33.48 B N ATOM 12373 CA THR B 256 61.550 8.236 −14.970 1.00 32.03 B C ATOM 12375 CB THR B 256 61.489 9.676 −15.484 1.00 28.82 B C ATOM 12377 OG1 THR B 256 61.258 10.518 −14.365 1.00 31.10 B O ATOM 12379 CG2 THR B 256 60.378 9.886 −16.462 1.00 32.38 B C ATOM 12383 C THR B 256 61.529 7.209 −16.104 1.00 31.37 B C ATOM 12384 O THR B 256 60.465 6.736 −16.483 1.00 30.12 B O ATOM 12386 N SER B 257 62.704 6.859 −16.632 1.00 32.20 B N ATOM 12387 CA SER B 257 62.816 5.812 −17.662 1.00 32.63 B C ATOM 12389 CB SER B 257 64.257 5.674 −18.156 1.00 32.05 B C ATOM 12392 OG SER B 257 64.640 6.805 −18.913 1.00 35.00 B O ATOM 12394 C SER B 257 62.329 4.460 −17.135 1.00 32.30 B C ATOM 12395 O SER B 257 61.626 3.731 −17.836 1.00 32.52 B O ATOM 12397 N ARG B 258 62.687 4.150 −15.893 1.00 31.83 B N ATOM 12398 CA ARG B 258 62.215 2.934 −15.244 1.00 35.46 B C ATOM 12400 CB ARG B 258 62.737 2.777 −13.798 1.00 37.72 B C ATOM 12403 CG ARG B 258 64.138 2.136 −13.696 1.00 46.00 B C ATOM 12406 CD ARG B 258 64.423 1.530 −12.295 1.00 51.03 B C ATOM 12409 NE ARG B 258 64.165 2.474 −11.198 1.00 52.82 B N ATOM 12411 CZ ARG B 258 65.033 3.368 −10.717 1.00 56.37 B C ATOM 12412 NH1 ARG B 258 64.663 4.155 −9.715 1.00 57.59 B N ATOM 12415 NH2 ARG B 258 66.261 3.492 −11.219 1.00 58.73 B N ATOM 12418 C ARG B 258 60.715 2.938 −15.235 1.00 33.44 B C ATOM 12419 O ARG B 258 60.098 1.963 −15.640 1.00 34.72 B O ATOM 12421 N TRP B 259 60.132 4.032 −14.773 1.00 31.58 B N ATOM 12422 CA TRP B 259 58.695 4.182 −14.811 1.00 31.82 B C ATOM 12424 CB TRP B 259 58.281 5.561 −14.324 1.00 32.08 B C ATOM 12427 CG TRP B 259 56.866 5.918 −14.621 1.00 27.02 B C ATOM 12428 CD1 TRP B 259 55.764 5.504 −13.935 1.00 30.20 B C ATOM 12430 NE1 TRP B 259 54.632 6.051 −14.491 1.00 34.18 B N ATOM 12432 CE2 TRP B 259 54.991 6.832 −15.558 1.00 25.57 B C ATOM 12433 CD2 TRP B 259 56.394 6.780 −15.666 1.00 26.24 B C ATOM 12434 CE3 TRP B 259 57.015 7.473 −16.706 1.00 21.19 B C ATOM 12436 CZ3 TRP B 259 56.238 8.204 −17.569 1.00 25.68 B C ATOM 12438 CH2 TRP B 259 54.848 8.253 −17.423 1.00 31.07 B C ATOM 12440 CZ2 TRP B 259 54.209 7.562 −16.425 1.00 26.47 B C ATOM 12442 C TRP B 259 58.158 3.980 −16.222 1.00 31.90 B C ATOM 12443 O TRP B 259 57.209 3.231 −16.416 1.00 34.40 B O ATOM 12445 N TRP B 260 58.755 4.650 −17.201 1.00 29.58 B N ATOM 12446 CA TRP B 260 58.219 4.623 −18.564 1.00 29.21 B C ATOM 12448 CB TRP B 260 59.020 5.542 −19.471 1.00 28.39 B C ATOM 12451 CG TRP B 260 58.463 5.760 −20.832 1.00 31.21 B C ATOM 12452 CD1 TRP B 260 59.128 5.613 −22.011 1.00 32.56 B C ATOM 12454 NE1 TRP B 260 58.305 5.952 −23.056 1.00 35.69 B N ATOM 12456 CE2 TRP B 260 57.088 6.341 −22.564 1.00 28.01 B C ATOM 12457 CD2 TRP B 260 57.140 6.220 −21.171 1.00 26.28 B C ATOM 12458 CE3 TRP B 260 56.006 6.556 −20.426 1.00 29.49 B C ATOM 12460 CZ3 TRP B 260 54.871 6.979 −21.092 1.00 27.25 B C ATOM 12462 CH2 TRP B 260 54.851 7.081 −22.477 1.00 26.73 B C ATOM 12464 CZ2 TRP B 260 55.947 6.764 −23.232 1.00 32.88 B C ATOM 12466 C TRP B 260 58.244 3.226 −19.150 1.00 27.50 B C ATOM 12467 O TRP B 260 57.308 2.844 −19.832 1.00 23.27 B O ATOM 12469 N ARG B 261 59.324 2.503 −18.865 1.00 29.60 B N ATOM 12470 CA ARG B 261 59.551 1.144 −19.348 1.00 34.53 B C ATOM 12472 CB ARG B 261 60.971 0.697 −18.977 1.00 35.16 B C ATOM 12475 CG ARG B 261 61.605 −0.290 −19.932 1.00 46.23 B C ATOM 12478 CD ARG B 261 63.068 −0.626 −19.554 1.00 55.36 B C ATOM 12481 NE ARG B 261 63.895 0.584 −19.412 1.00 60.95 B N ATOM 12483 CZ ARG B 261 64.475 1.013 −18.281 1.00 63.65 B C ATOM 12484 NH1 ARG B 261 65.189 2.134 −18.300 1.00 57.86 B N ATOM 12487 NH2 ARG B 261 64.369 0.342 −17.130 1.00 65.79 B N ATOM 12490 C ARG B 261 58.509 0.198 −18.741 1.00 37.14 B C ATOM 12491 O ARG B 261 57.920 −0.634 −19.435 1.00 39.01 B O ATOM 12493 N ARG B 262 58.284 0.360 −17.442 1.00 38.02 B N ATOM 12494 CA ARG B 262 57.177 −0.268 −16.716 1.00 39.33 B C ATOM 12496 CB ARG B 262 57.015 0.410 −15.345 1.00 43.52 B C ATOM 12499 CG ARG B 262 56.465 −0.472 −14.256 1.00 52.63 B C ATOM 12502 CD ARG B 262 57.576 −1.181 −13.525 1.00 62.09 B C ATOM 12505 NE ARG B 262 57.050 −2.325 −12.786 1.00 69.73 B N ATOM 12507 CZ ARG B 262 56.722 −3.494 −13.333 1.00 71.95 B C ATOM 12508 NH1 ARG B 262 56.865 −3.698 −14.642 1.00 69.88 B N ATOM 12511 NH2 ARG B 262 56.243 −4.462 −12.561 1.00 73.11 B N ATOM 12514 C ARG B 262 55.852 −0.134 −17.434 1.00 34.28 B C ATOM 12515 O ARG B 262 55.161 −1.109 −17.686 1.00 36.30 B O ATOM 12517 N VAL B 263 55.504 1.100 −17.747 1.00 30.95 B N ATOM 12518 CA VAL B 263 54.232 1.419 −18.372 1.00 28.88 B C ATOM 12520 CB VAL B 263 53.991 2.937 −18.339 1.00 29.02 B C ATOM 12522 CG1 VAL B 263 53.972 3.419 −16.887 1.00 31.64 B C ATOM 12526 CG2 VAL B 263 52.725 3.282 −19.018 1.00 23.71 B C ATOM 12530 C VAL B 263 54.178 0.879 −19.806 1.00 28.33 B C ATOM 12531 O VAL B 263 53.120 0.527 −20.282 1.00 28.41 B O ATOM 12533 N GLY B 264 55.328 0.793 −20.473 1.00 28.72 B N ATOM 12534 CA GLY B 264 55.455 0.142 −21.782 1.00 28.49 B C ATOM 12537 C GLY B 264 54.407 0.496 −22.813 1.00 29.83 B C ATOM 12538 O GLY B 264 54.075 −0.304 −23.665 1.00 33.27 B O ATOM 12540 N LEU B 265 53.866 1.692 −22.740 1.00 32.92 B N ATOM 12541 CA LEU B 265 52.709 2.035 −23.561 1.00 36.59 B C ATOM 12543 CB LEU B 265 52.038 3.282 −22.981 1.00 34.56 B C ATOM 12546 CG LEU B 265 50.645 3.685 −23.411 1.00 34.01 B C ATOM 12548 CD1 LEU B 265 49.599 2.606 −23.171 1.00 25.90 B C ATOM 12552 CD2 LEU B 265 50.267 4.994 −22.672 1.00 34.22 B C ATOM 12556 C LEU B 265 53.113 2.229 −25.033 1.00 41.17 B C ATOM 12557 O LEU B 265 52.405 1.785 −25.947 1.00 40.79 B O ATOM 12559 N ALA B 266 54.263 2.867 −25.250 1.00 45.34 B N ATOM 12560 CA ALA B 266 54.839 3.029 −26.591 1.00 49.21 B C ATOM 12562 CB ALA B 266 56.169 3.765 −26.497 1.00 51.02 B C ATOM 12566 C ALA B 266 55.042 1.697 −27.325 1.00 51.05 B C ATOM 12567 O ALA B 266 54.816 1.605 −28.525 1.00 54.29 B O ATOM 12569 N THR B 267 55.487 0.674 −26.602 1.00 51.62 B N ATOM 12570 CA THR B 267 55.674 −0.659 −27.166 1.00 50.64 B C ATOM 12572 CB THR B 267 56.249 −1.603 −26.109 1.00 50.95 B C ATOM 12574 OG1 THR B 267 57.237 −0.904 −25.348 1.00 53.05 B O ATOM 12576 CG2 THR B 267 56.856 −2.837 −26.747 1.00 53.61 B C ATOM 12580 C THR B 267 54.363 −1.270 −27.629 1.00 49.87 B C ATOM 12581 O THR B 267 54.276 −1.822 −28.729 1.00 52.54 B O ATOM 12583 N LYS B 268 53.345 −1.168 −26.781 1.00 47.07 B N ATOM 12584 CA LYS B 268 52.106 −1.927 −26.953 1.00 45.30 B C ATOM 12586 CB LYS B 268 51.514 −2.270 −25.578 1.00 45.48 B C ATOM 12589 CG LYS B 268 52.430 −3.115 −24.675 1.00 45.38 B C ATOM 12592 CD LYS B 268 52.465 −4.594 −25.090 1.00 49.05 B C ATOM 12595 CE LYS B 268 53.528 −5.398 −24.328 1.00 51.83 B C ATOM 12598 NZ LYS B 268 53.838 −6.705 −24.985 1.00 54.82 B N ATOM 12602 C LYS B 268 51.078 −1.207 −27.819 1.00 43.95 B C ATOM 12603 O LYS B 268 50.152 −1.829 −28.343 1.00 44.75 B O ATOM 12605 N LEU B 269 51.229 0.105 −27.947 1.00 43.27 B N ATOM 12606 CA LEU B 269 50.456 0.896 −28.900 1.00 42.83 B C ATOM 12608 CB LEU B 269 50.081 2.274 −28.316 1.00 42.53 B C ATOM 12611 CG LEU B 269 48.694 2.512 −27.709 1.00 42.48 B C ATOM 12613 CD1 LEU B 269 48.340 1.537 −26.633 1.00 40.39 B C ATOM 12617 CD2 LEU B 269 48.603 3.935 −27.181 1.00 43.69 B C ATOM 12621 C LEU B 269 51.341 1.081 −30.134 1.00 43.67 B C ATOM 12622 O LEU B 269 52.298 1.875 −30.115 1.00 44.75 B O ATOM 12624 N HIS B 270 51.014 0.353 −31.200 1.00 42.52 B N ATOM 12625 CA HIS B 270 51.820 0.323 −32.430 1.00 42.36 B C ATOM 12627 CB HIS B 270 51.297 −0.765 −33.406 1.00 44.29 B C ATOM 12630 CG HIS B 270 50.914 −2.062 −32.743 1.00 55.81 B C ATOM 12631 ND1 HIS B 270 51.604 −2.596 −31.670 1.00 59.93 B N ATOM 12633 CE1 HIS B 270 51.038 −3.734 −31.307 1.00 61.45 B C ATOM 12635 NE2 HIS B 270 50.011 −3.964 −32.106 1.00 62.50 B N ATOM 12637 CD2 HIS B 270 49.910 −2.935 −33.012 1.00 61.72 B C ATOM 12639 C HIS B 270 51.862 1.683 −33.164 1.00 38.47 B C ATOM 12640 O HIS B 270 52.821 1.980 −33.872 1.00 36.44 B O ATOM 12642 N PHE B 271 50.813 2.487 −33.019 1.00 34.67 B N ATOM 12643 CA PHE B 271 50.782 3.831 −33.616 1.00 35.53 B C ATOM 12645 CB PHE B 271 49.327 4.306 −33.814 1.00 35.09 B C ATOM 12648 CG PHE B 271 48.598 4.542 −32.527 1.00 32.41 B C ATOM 12649 CD1 PHE B 271 48.680 5.764 −31.891 1.00 36.89 B C ATOM 12651 CE1 PHE B 271 48.031 5.986 −30.662 1.00 42.82 B C ATOM 12653 CZ PHE B 271 47.311 4.955 −30.061 1.00 41.42 B C ATOM 12655 CE2 PHE B 271 47.234 3.714 −30.695 1.00 43.35 B C ATOM 12657 CD2 PHE B 271 47.881 3.516 −31.920 1.00 37.61 B C ATOM 12659 C PHE B 271 51.570 4.893 −32.797 1.00 37.13 B C ATOM 12660 O PHE B 271 51.846 5.976 −33.321 1.00 37.34 B O ATOM 12662 N ALA B 272 51.940 4.589 −31.543 1.00 37.26 B N ATOM 12663 CA ALA B 272 52.442 5.634 −30.600 1.00 38.89 B C ATOM 12665 CB ALA B 272 52.094 5.270 −29.140 1.00 36.66 B C ATOM 12669 C ALA B 272 53.938 5.971 −30.703 1.00 39.07 B C ATOM 12670 O ALA B 272 54.797 5.092 −30.725 1.00 39.92 B O ATOM 12672 N ARG B 273 54.230 7.265 −30.746 1.00 41.88 B N ATOM 12673 CA ARG B 273 55.598 7.754 −30.590 1.00 43.68 B C ATOM 12675 CB ARG B 273 55.688 9.247 −30.928 1.00 45.24 B C ATOM 12678 CG ARG B 273 55.566 9.610 −32.409 1.00 54.15 B C ATOM 12681 CD ARG B 273 55.488 11.141 −32.589 1.00 58.80 B C ATOM 12684 NE ARG B 273 54.171 11.685 −32.226 1.00 59.04 B N ATOM 12686 CZ ARG B 273 53.934 12.957 −31.892 1.00 67.66 B C ATOM 12687 NH1 ARG B 273 54.925 13.849 −31.851 1.00 73.10 B N ATOM 12690 NH2 ARG B 273 52.699 13.348 −31.579 1.00 66.54 B N ATOM 12693 C ARG B 273 56.033 7.570 −29.146 1.00 42.37 B C ATOM 12694 O ARG B 273 55.259 7.841 −28.231 1.00 44.16 B O ATOM 12696 N ASP B 274 57.259 7.102 −28.953 1.00 41.17 B N ATOM 12697 CA ASP B 274 57.943 7.200 −27.663 1.00 39.65 B C ATOM 12699 CB ASP B 274 58.887 6.003 −27.479 1.00 37.65 B C ATOM 12702 CG ASP B 274 59.781 6.132 −26.246 1.00 41.72 B C ATOM 12703 OD1 ASP B 274 59.773 7.202 −25.594 1.00 40.60 B O ATOM 12704 OD2 ASP B 274 60.514 5.165 −25.926 1.00 46.31 B O ATOM 12705 C ASP B 274 58.730 8.542 −27.618 1.00 39.30 B C ATOM 12706 O ASP B 274 59.720 8.711 −28.349 1.00 38.18 B O ATOM 12708 N ARG B 275 58.307 9.459 −26.744 1.00 38.02 B N ATOM 12709 CA ARG B 275 58.890 10.796 −26.645 1.00 38.08 B C ATOM 12711 CB ARG B 275 57.833 11.834 −27.058 1.00 39.92 B C ATOM 12714 CG ARG B 275 57.840 12.200 −28.556 1.00 47.80 B C ATOM 12717 CD ARG B 275 58.691 13.450 −28.835 1.00 61.16 B C ATOM 12720 NE ARG B 275 58.526 13.945 −30.206 1.00 68.47 B N ATOM 12722 CZ ARG B 275 59.096 13.401 −31.281 1.00 74.79 B C ATOM 12723 NH1 ARG B 275 59.875 12.326 −31.169 1.00 76.37 B N ATOM 12726 NH2 ARG B 275 58.876 13.926 −32.484 1.00 75.18 B N ATOM 12729 C ARG B 275 59.425 11.147 −25.254 1.00 37.19 B C ATOM 12730 O ARG B 275 59.433 12.316 −24.879 1.00 36.87 B O ATOM 12732 N LEU B 276 59.886 10.160 −24.485 1.00 37.00 B N ATOM 12733 CA LEU B 276 60.295 10.426 −23.098 1.00 34.98 B C ATOM 12735 CB LEU B 276 60.573 9.134 −22.292 1.00 36.67 B C ATOM 12738 CG LEU B 276 60.890 9.375 −20.797 1.00 35.76 B C ATOM 12740 CD1 LEU B 276 59.754 10.147 −20.115 1.00 33.92 B C ATOM 12744 CD2 LEU B 276 61.169 8.113 −20.053 1.00 36.13 B C ATOM 12748 C LEU B 276 61.503 11.363 −23.013 1.00 32.92 B C ATOM 12749 O LEU B 276 61.435 12.361 −22.318 1.00 31.67 B O ATOM 12751 N ILE B 277 62.582 11.055 −23.725 1.00 30.95 B N ATOM 12752 CA ILE B 277 63.822 11.841 −23.617 1.00 29.96 B C ATOM 12754 CB ILE B 277 64.948 11.249 −24.510 1.00 31.64 B C ATOM 12756 CG1 ILE B 277 65.404 9.882 −23.979 1.00 34.19 B C ATOM 12759 CD1 ILE B 277 66.155 9.043 −25.015 1.00 37.10 B C ATOM 12763 CG2 ILE B 277 66.155 12.185 −24.569 1.00 30.97 B C ATOM 12767 C ILE B 277 63.591 13.296 −24.024 1.00 29.71 B C ATOM 12768 O ILE B 277 64.075 14.213 −23.367 1.00 29.06 B O ATOM 12770 N GLU B 278 62.851 13.492 −25.113 1.00 28.47 B N ATOM 12771 CA GLU B 278 62.515 14.814 −25.599 1.00 30.52 B C ATOM 12773 CB GLU B 278 61.773 14.746 −26.949 1.00 32.74 B C ATOM 12776 CG GLU B 278 62.616 14.225 −28.148 1.00 44.05 B C ATOM 12779 CD GLU B 278 62.477 12.706 −28.437 1.00 50.83 B C ATOM 12780 OE1 GLU B 278 62.589 11.868 −27.508 1.00 47.29 B O ATOM 12781 OE2 GLU B 278 62.263 12.357 −29.624 1.00 59.50 B O ATOM 12782 C GLU B 278 61.650 15.529 −24.554 1.00 29.96 B C ATOM 12783 O GLU B 278 61.811 16.720 −24.328 1.00 29.51 B O ATOM 12785 N SER B 279 60.753 14.787 −23.900 1.00 27.64 B N ATOM 12786 CA SER B 279 59.880 15.369 −22.906 1.00 24.85 B C ATOM 12788 CB SER B 279 58.779 14.387 −22.528 1.00 25.36 B C ATOM 12791 OG SER B 279 57.866 14.222 −23.614 1.00 31.09 B O ATOM 12793 C SER B 279 60.692 15.817 −21.689 1.00 24.19 B C ATOM 12794 O SER B 279 60.402 16.841 −21.072 1.00 20.81 B O ATOM 12796 N PHE B 280 61.726 15.060 −21.358 1.00 22.21 B N ATOM 12797 CA PHE B 280 62.538 15.405 −20.233 1.00 22.68 B C ATOM 12799 CB PHE B 280 63.394 14.219 −19.801 1.00 23.70 B C ATOM 12802 CG PHE B 280 63.993 14.420 −18.458 1.00 22.17 B C ATOM 12803 CD1 PHE B 280 63.282 14.110 −17.326 1.00 26.73 B C ATOM 12805 CE1 PHE B 280 63.815 14.336 −16.082 1.00 28.79 B C ATOM 12807 CZ PHE B 280 65.071 14.912 −15.977 1.00 26.30 B C ATOM 12809 CE2 PHE B 280 65.767 15.240 −17.094 1.00 23.82 B C ATOM 12811 CD2 PHE B 280 65.224 15.010 −18.332 1.00 25.89 B C ATOM 12813 C PHE B 280 63.421 16.639 −20.521 1.00 23.35 B C ATOM 12814 O PHE B 280 63.538 17.546 −19.684 1.00 22.15 B O ATOM 12816 N TYR B 281 64.035 16.663 −21.702 1.00 22.05 B N ATOM 12817 CA TYR B 281 64.744 17.845 −22.179 1.00 22.89 B C ATOM 12819 CB TYR B 281 65.243 17.599 −23.613 1.00 24.85 B C ATOM 12822 CG TYR B 281 65.725 18.824 −24.340 1.00 27.86 B C ATOM 12823 CD1 TYR B 281 67.038 19.263 −24.199 1.00 29.60 B C ATOM 12825 CE1 TYR B 281 67.481 20.396 −24.830 1.00 30.12 B C ATOM 12827 CZ TYR B 281 66.619 21.106 −25.645 1.00 27.86 B C ATOM 12828 OH TYR B 281 67.094 22.218 −26.293 1.00 40.12 B O ATOM 12830 CE2 TYR B 281 65.321 20.681 −25.831 1.00 27.61 B C ATOM 12832 CD2 TYR B 281 64.880 19.541 −25.164 1.00 26.08 B C ATOM 12834 C TYR B 281 63.774 19.033 −22.107 1.00 23.97 B C ATOM 12835 O TYR B 281 64.114 20.107 −21.638 1.00 23.50 B O ATOM 12837 N TRP B 282 62.535 18.821 −22.522 1.00 23.00 B N ATOM 12838 CA TRP B 282 61.567 19.906 −22.475 1.00 23.33 B C ATOM 12840 CB TRP B 282 60.235 19.447 −23.059 1.00 22.37 B C ATOM 12843 CG TRP B 282 59.154 20.412 −22.895 1.00 22.74 B C ATOM 12844 CD1 TRP B 282 58.337 20.555 −21.821 1.00 22.39 B C ATOM 12846 NE1 TRP B 282 57.435 21.564 −22.047 1.00 23.45 B N ATOM 12848 CE2 TRP B 282 57.667 22.082 −23.291 1.00 23.69 B C ATOM 12849 CD2 TRP B 282 58.742 21.375 −23.850 1.00 22.10 B C ATOM 12850 CE3 TRP B 282 59.184 21.712 −25.131 1.00 26.55 B C ATOM 12852 CZ3 TRP B 282 58.546 22.733 −25.798 1.00 28.88 B C ATOM 12854 CH2 TRP B 282 57.483 23.424 −25.210 1.00 30.17 B C ATOM 12856 CZ2 TRP B 282 57.028 23.111 −23.960 1.00 27.03 B C ATOM 12858 C TRP B 282 61.418 20.387 −21.028 1.00 22.80 B C ATOM 12859 O TRP B 282 61.406 21.593 −20.769 1.00 20.61 B O ATOM 12861 N ALA B 283 61.308 19.431 −20.103 1.00 21.05 B N ATOM 12862 CA ALA B 283 61.084 19.723 −18.692 1.00 20.62 B C ATOM 12864 CB ALA B 283 60.816 18.452 −17.899 1.00 18.78 B C ATOM 12868 C ALA B 283 62.249 20.468 −18.081 1.00 19.81 B C ATOM 12869 O ALA B 283 62.048 21.246 −17.179 1.00 19.59 B O ATOM 12871 N VAL B 284 63.459 20.228 −18.570 1.00 21.14 B N ATOM 12872 CA VAL B 284 64.621 20.924 −18.054 1.00 22.45 B C ATOM 12874 CB VAL B 284 65.935 20.350 −18.615 1.00 25.86 B C ATOM 12876 CG1 VAL B 284 66.234 18.966 −17.953 1.00 18.72 B C ATOM 12880 CG2 VAL B 284 67.075 21.325 −18.378 1.00 20.18 B C ATOM 12884 C VAL B 284 64.537 22.416 −18.333 1.00 23.71 B C ATOM 12885 O VAL B 284 64.993 23.221 −17.526 1.00 22.26 B O ATOM 12887 N GLY B 285 63.948 22.793 −19.464 1.00 21.46 B N ATOM 12888 CA GLY B 285 63.763 24.215 −19.762 1.00 20.96 B C ATOM 12891 C GLY B 285 62.773 24.857 −18.808 1.00 21.82 B C ATOM 12892 O GLY B 285 62.909 26.011 −18.460 1.00 21.74 B O ATOM 12894 N VAL B 286 61.794 24.090 −18.345 1.00 22.60 B N ATOM 12895 CA VAL B 286 60.781 24.620 −17.450 1.00 20.48 B C ATOM 12897 CB VAL B 286 59.539 23.732 −17.498 1.00 23.12 B C ATOM 12899 CG1 VAL B 286 58.485 24.177 −16.490 1.00 20.49 B C ATOM 12903 CG2 VAL B 286 58.976 23.732 −18.955 1.00 17.84 B C ATOM 12907 C VAL B 286 61.309 24.792 −16.046 1.00 20.31 B C ATOM 12908 O VAL B 286 61.106 25.842 −15.436 1.00 22.39 B O ATOM 12910 N ALA B 287 61.979 23.772 −15.527 1.00 19.27 B N ATOM 12911 CA ALA B 287 62.563 23.827 −14.186 1.00 20.62 B C ATOM 12913 CB ALA B 287 61.690 23.117 −13.227 1.00 22.01 B C ATOM 12917 C ALA B 287 63.988 23.242 −14.163 1.00 21.88 B C ATOM 12918 O ALA B 287 64.196 22.022 −14.069 1.00 24.85 B O ATOM 12920 N PHE B 288 64.972 24.115 −14.247 1.00 20.90 B N ATOM 12921 CA PHE B 288 66.345 23.674 −14.426 1.00 21.67 B C ATOM 12923 CB PHE B 288 67.122 24.674 −15.275 1.00 22.83 B C ATOM 12926 CG PHE B 288 67.541 25.900 −14.520 1.00 23.91 B C ATOM 12927 CD1 PHE B 288 68.710 25.905 −13.784 1.00 33.80 B C ATOM 12929 CE1 PHE B 288 69.088 27.037 −13.074 1.00 37.48 B C ATOM 12931 CZ PHE B 288 68.287 28.167 −13.095 1.00 31.38 B C ATOM 12933 CE2 PHE B 288 67.137 28.167 −13.821 1.00 36.32 B C ATOM 12935 CD2 PHE B 288 66.761 27.029 −14.529 1.00 34.62 B C ATOM 12937 C PHE B 288 67.047 23.497 −13.099 1.00 24.48 B C ATOM 12938 O PHE B 288 68.005 22.741 −13.031 1.00 23.65 B O ATOM 12940 N GLU B 289 66.587 24.190 −12.057 1.00 26.02 B N ATOM 12941 CA GLU B 289 67.310 24.197 −10.792 1.00 29.62 B C ATOM 12943 CB GLU B 289 66.689 25.166 −9.776 1.00 31.32 B C ATOM 12946 CG GLU B 289 66.721 26.644 −10.177 1.00 36.70 B C ATOM 12949 CD GLU B 289 65.440 27.118 −10.890 1.00 45.07 B C ATOM 12950 OE1 GLU B 289 65.081 28.295 −10.677 1.00 47.42 B O ATOM 12951 OE2 GLU B 289 64.793 26.352 −11.659 1.00 39.96 B O ATOM 12952 C GLU B 289 67.350 22.795 −10.180 1.00 29.55 B C ATOM 12953 O GLU B 289 66.350 22.084 −10.180 1.00 30.10 B O ATOM 12955 N PRO B 290 68.495 22.419 −9.606 1.00 29.22 B N ATOM 12956 CA PRO B 290 68.716 21.062 −9.120 1.00 28.35 B C ATOM 12958 CB PRO B 290 69.998 21.185 −8.304 1.00 29.34 B C ATOM 12961 CG PRO B 290 70.632 22.443 −8.746 1.00 31.20 B C ATOM 12964 CD PRO B 290 69.568 23.338 −9.199 1.00 29.41 B C ATOM 12967 C PRO B 290 67.597 20.503 −8.245 1.00 27.13 B C ATOM 12968 O PRO B 290 67.211 19.356 −8.429 1.00 26.99 B O ATOM 12969 N GLN B 291 67.073 21.317 −7.333 1.00 26.56 B N ATOM 12970 CA GLN B 291 66.043 20.889 −6.395 1.00 28.08 B C ATOM 12972 CB GLN B 291 65.903 21.923 −5.273 1.00 28.20 B C ATOM 12975 CG GLN B 291 65.226 23.240 −5.649 1.00 29.54 B C ATOM 12978 CD GLN B 291 66.216 24.301 −6.116 1.00 39.09 B C ATOM 12979 OE1 GLN B 291 67.318 23.982 −6.604 1.00 38.40 B O ATOM 12980 NE2 GLN B 291 65.835 25.579 −5.957 1.00 34.88 B N ATOM 12983 C GLN B 291 64.631 20.595 −6.967 1.00 28.38 B C ATOM 12984 O GLN B 291 63.778 20.058 −6.256 1.00 28.46 B O ATOM 12986 N TYR B 292 64.375 20.955 −8.219 1.00 28.39 B N ATOM 12987 CA TYR B 292 63.043 20.732 −8.817 1.00 29.49 B C ATOM 12989 CB TYR B 292 62.665 21.897 −9.751 1.00 29.50 B C ATOM 12992 CG TYR B 292 62.448 23.230 −9.077 1.00 31.00 B C ATOM 12993 CD1 TYR B 292 61.801 23.327 −7.844 1.00 32.31 B C ATOM 12995 CE1 TYR B 292 61.595 24.565 −7.235 1.00 36.98 B C ATOM 12997 CZ TYR B 292 62.016 25.723 −7.869 1.00 39.38 B C ATOM 12998 OH TYR B 292 61.804 26.951 −7.281 1.00 45.92 B O ATOM 13000 CE2 TYR B 292 62.634 25.655 −9.106 1.00 42.09 B C ATOM 13002 CD2 TYR B 292 62.849 24.413 −9.701 1.00 39.44 B C ATOM 13004 C TYR B 292 62.942 19.410 −9.590 1.00 28.42 B C ATOM 13005 O TYR B 292 62.355 19.362 −10.659 1.00 27.22 B O ATOM 13007 N SER B 293 63.523 18.344 −9.050 1.00 28.09 B N ATOM 13008 CA SER B 293 63.430 17.036 −9.669 1.00 28.01 B C ATOM 13010 CB SER B 293 64.181 15.987 −8.824 1.00 29.51 B C ATOM 13013 OG SER B 293 65.590 16.068 −9.070 1.00 30.76 B O ATOM 13015 C SER B 293 61.973 16.635 −9.898 1.00 26.55 B C ATOM 13016 O SER B 293 61.634 16.155 −10.968 1.00 28.86 B O ATOM 13018 N ASP B 294 61.120 16.853 −8.907 1.00 25.23 B N ATOM 13019 CA ASP B 294 59.721 16.469 −9.000 1.00 28.08 B C ATOM 13021 CB ASP B 294 58.962 16.785 −7.696 1.00 28.58 B C ATOM 13024 CG ASP B 294 59.432 15.942 −6.522 1.00 37.32 B C ATOM 13025 OD1 ASP B 294 60.154 14.943 −6.741 1.00 36.71 B O ATOM 13026 OD2 ASP B 294 59.094 16.301 −5.363 1.00 45.41 B O ATOM 13027 C ASP B 294 59.019 17.171 −10.163 1.00 28.26 B C ATOM 13028 O ASP B 294 58.249 16.544 −10.891 1.00 27.19 B O ATOM 13030 N CYS B 295 59.261 18.477 −10.298 1.00 26.75 B N ATOM 13031 CA CYS B 295 58.687 19.249 −11.376 1.00 24.72 B C ATOM 13033 CB CYS B 295 59.091 20.714 −11.313 1.00 24.78 B C ATOM 13036 SG CYS B 295 58.157 21.730 −12.489 1.00 24.85 B S ATOM 13038 C CYS B 295 59.090 18.651 −12.702 1.00 25.01 B C ATOM 13039 O CYS B 295 58.222 18.397 −13.539 1.00 23.90 B O ATOM 13041 N ARG B 296 60.386 18.396 −12.893 1.00 24.46 B N ATOM 13042 CA ARG B 296 60.851 17.831 −14.172 1.00 24.09 B C ATOM 13044 CB ARG B 296 62.369 17.647 −14.205 1.00 24.77 B C ATOM 13047 CG ARG B 296 63.153 18.936 −14.354 1.00 23.30 B C ATOM 13050 CD ARG B 296 64.643 18.682 −14.514 1.00 19.69 B C ATOM 13053 NE ARG B 296 65.243 18.178 −13.289 1.00 19.76 B N ATOM 13055 CZ ARG B 296 65.634 18.927 −12.254 1.00 24.50 B C ATOM 13056 NH1 ARG B 296 65.496 20.255 −12.255 1.00 25.75 B N ATOM 13059 NH2 ARG B 296 66.166 18.328 −11.191 1.00 27.06 B N ATOM 13062 C ARG B 296 60.185 16.495 −14.463 1.00 23.06 B C ATOM 13063 O ARG B 296 59.718 16.245 −15.597 1.00 22.98 B O ATOM 13065 N ASN B 297 60.138 15.641 −13.447 1.00 22.07 B N ATOM 13066 CA ASN B 297 59.565 14.316 −13.609 1.00 24.36 B C ATOM 13068 CB ASN B 297 59.763 13.460 −12.364 1.00 24.91 B C ATOM 13071 CG ASN B 297 61.206 13.110 −12.150 1.00 31.79 B C ATOM 13072 OD1 ASN B 297 61.998 13.156 −13.095 1.00 38.41 B O ATOM 13073 ND2 ASN B 297 61.570 12.757 −10.911 1.00 29.95 B N ATOM 13076 C ASN B 297 58.095 14.399 −13.952 1.00 24.42 B C ATOM 13077 O ASN B 297 57.622 13.726 −14.876 1.00 23.19 B O ATOM 13079 N SER B 298 57.393 15.242 −13.215 1.00 23.97 B N ATOM 13080 CA SER B 298 55.976 15.474 −13.444 1.00 24.63 B C ATOM 13082 CB SER B 298 55.466 16.475 −12.403 1.00 25.85 B C ATOM 13085 OG SER B 298 54.275 16.038 −11.808 1.00 36.11 B O ATOM 13087 C SER B 298 55.694 16.009 −14.851 1.00 23.06 B C ATOM 13088 O SER B 298 54.827 15.490 −15.572 1.00 21.42 B O ATOM 13090 N VAL B 299 56.412 17.066 −15.240 1.00 20.75 B N ATOM 13091 CA VAL B 299 56.238 17.639 −16.554 1.00 18.08 B C ATOM 13093 CB VAL B 299 57.037 18.933 −16.690 1.00 19.98 B C ATOM 13095 CG1 VAL B 299 57.029 19.453 −18.146 1.00 20.35 B C ATOM 13099 CG2 VAL B 299 56.457 19.960 −15.770 1.00 21.88 B C ATOM 13103 C VAL B 299 56.636 16.633 −17.648 1.00 19.45 B C ATOM 13104 O VAL B 299 55.996 16.570 −18.700 1.00 17.92 B O ATOM 13106 N ALA B 300 57.665 15.826 −17.393 1.00 18.10 B N ATOM 13107 CA ALA B 300 58.147 14.869 −18.404 1.00 19.47 B C ATOM 13109 CB ALA B 300 59.535 14.263 −18.011 1.00 15.98 B C ATOM 13113 C ALA B 300 57.121 13.762 −18.590 1.00 20.75 B C ATOM 13114 O ALA B 300 56.813 13.354 −19.714 1.00 21.28 B O ATOM 13116 N LYS B 301 56.573 13.283 −17.482 1.00 21.38 B N ATOM 13117 CA LYS B 301 55.560 12.239 −17.553 1.00 20.81 B C ATOM 13119 CB LYS B 301 55.187 11.785 −16.160 1.00 20.47 B C ATOM 13122 CG LYS B 301 56.259 10.978 −15.481 1.00 20.34 B C ATOM 13125 CD LYS B 301 55.758 10.422 −14.150 1.00 20.67 B C ATOM 13128 CE LYS B 301 56.846 9.711 −13.349 1.00 28.61 B C ATOM 13131 NZ LYS B 301 56.310 9.346 −11.992 1.00 31.10 B N ATOM 13135 C LYS B 301 54.313 12.719 −18.283 1.00 19.17 B C ATOM 13136 O LYS B 301 53.752 11.998 −19.088 1.00 19.72 B O ATOM 13138 N MET B 302 53.880 13.940 −17.995 1.00 18.82 B N ATOM 13139 CA MET B 302 52.656 14.473 −18.598 1.00 19.48 B C ATOM 13141 CB MET B 302 52.169 15.752 −17.900 1.00 18.45 B C ATOM 13144 CG MET B 302 51.728 15.582 −16.463 1.00 16.26 B C ATOM 13147 SD MET B 302 50.418 14.399 −16.251 1.00 27.62 B S ATOM 13148 CE MET B 302 51.337 12.933 −15.824 1.00 23.65 B C ATOM 13152 C MET B 302 52.860 14.765 −20.067 1.00 21.47 B C ATOM 13153 O MET B 302 52.007 14.431 −20.896 1.00 23.42 B O ATOM 13155 N PHE B 303 53.966 15.404 −20.412 1.00 21.99 B N ATOM 13156 CA PHE B 303 54.225 15.621 −21.834 1.00 22.67 B C ATOM 13158 CB PHE B 303 55.475 16.466 −22.069 1.00 23.73 B C ATOM 13161 CG PHE B 303 55.398 17.344 −23.304 1.00 31.04 B C ATOM 13162 CD1 PHE B 303 54.200 17.518 −24.009 1.00 29.05 B C ATOM 13164 CE1 PHE B 303 54.144 18.322 −25.144 1.00 42.79 B C ATOM 13166 CZ PHE B 303 55.280 18.986 −25.577 1.00 41.71 B C ATOM 13168 CE2 PHE B 303 56.469 18.843 −24.877 1.00 37.08 B C ATOM 13170 CD2 PHE B 303 56.525 18.023 −23.742 1.00 37.60 B C ATOM 13172 C PHE B 303 54.312 14.315 −22.621 1.00 21.08 B C ATOM 13173 O PHE B 303 53.799 14.238 −23.733 1.00 21.61 B O ATOM 13175 N SER B 304 54.907 13.277 −22.036 1.00 21.32 B N ATOM 13176 CA SER B 304 54.949 11.965 −22.692 1.00 20.73 B C ATOM 13178 CB SER B 304 55.700 10.941 −21.850 1.00 22.39 B C ATOM 13181 OG SER B 304 57.032 11.374 −21.573 1.00 24.34 B O ATOM 13183 C SER B 304 53.551 11.444 −22.967 1.00 21.58 B C ATOM 13184 O SER B 304 53.296 10.929 −24.034 1.00 23.78 B O ATOM 13186 N PHE B 305 52.639 11.591 −22.011 1.00 21.21 B N ATOM 13187 CA PHE B 305 51.256 11.195 −22.225 1.00 19.19 B C ATOM 13189 CB PHE B 305 50.487 11.141 −20.903 1.00 21.39 B C ATOM 13192 CG PHE B 305 50.574 9.814 −20.230 1.00 22.98 B C ATOM 13193 CD1 PHE B 305 49.894 8.742 −20.738 1.00 22.59 B C ATOM 13195 CE1 PHE B 305 49.983 7.507 −20.135 1.00 23.64 B C ATOM 13197 CZ PHE B 305 50.747 7.338 −19.024 1.00 24.33 B C ATOM 13199 CE2 PHE B 305 51.435 8.406 −18.505 1.00 27.51 B C ATOM 13201 CD2 PHE B 305 51.349 9.634 −19.112 1.00 22.45 B C ATOM 13203 C PHE B 305 50.542 12.110 −23.197 1.00 20.45 B C ATOM 13204 O PHE B 305 49.770 11.631 −24.020 1.00 19.27 B O ATOM 13206 N VAL B 306 50.791 13.421 −23.126 1.00 20.75 B N ATOM 13207 CA VAL B 306 50.184 14.351 −24.081 1.00 19.25 B C ATOM 13209 CB VAL B 306 50.655 15.809 −23.878 1.00 22.43 B C ATOM 13211 CG1 VAL B 306 50.202 16.687 −25.012 1.00 14.46 B C ATOM 13215 CG2 VAL B 306 50.145 16.385 −22.528 1.00 16.22 B C ATOM 13219 C VAL B 306 50.464 13.914 −25.511 1.00 22.34 B C ATOM 13220 O VAL B 306 49.566 13.856 −26.316 1.00 23.30 B O ATOM 13222 N THR B 307 51.696 13.555 −25.830 1.00 25.01 B N ATOM 13223 CA THR B 307 52.025 13.284 −27.227 1.00 26.57 B C ATOM 13225 CB THR B 307 53.520 13.087 −27.435 1.00 26.12 B C ATOM 13227 OG1 THR B 307 53.909 11.896 −26.774 1.00 40.17 B O ATOM 13229 CG2 THR B 307 54.339 14.252 −26.872 1.00 33.09 B C ATOM 13233 C THR B 307 51.284 12.043 −27.757 1.00 26.12 B C ATOM 13234 O THR B 307 50.866 12.016 −28.903 1.00 25.66 B O ATOM 13236 N ILE B 308 51.139 11.031 −26.908 1.00 24.81 B N ATOM 13237 CA ILE B 308 50.352 9.833 −27.215 1.00 23.60 B C ATOM 13239 CB ILE B 308 50.545 8.768 −26.118 1.00 25.72 B C ATOM 13241 CG1 ILE B 308 51.994 8.263 −26.119 1.00 27.99 B C ATOM 13244 CD1 ILE B 308 52.272 7.297 −24.983 1.00 28.28 B C ATOM 13248 CG2 ILE B 308 49.588 7.595 −26.318 1.00 24.09 B C ATOM 13252 C ILE B 308 48.865 10.144 −27.337 1.00 22.14 B C ATOM 13253 O ILE B 308 48.245 9.781 −28.321 1.00 22.79 B O ATOM 13255 N ILE B 309 48.292 10.823 −26.344 1.00 20.84 B N ATOM 13256 CA ILE B 309 46.882 11.147 −26.371 1.00 21.20 B C ATOM 13258 CB ILE B 309 46.435 11.822 −25.093 1.00 22.62 B C ATOM 13260 CG1 ILE B 309 46.643 10.910 −23.874 1.00 26.22 B C ATOM 13263 CD1 ILE B 309 45.698 9.823 −23.812 1.00 38.91 B C ATOM 13267 CG2 ILE B 309 44.993 12.206 −25.188 1.00 18.44 B C ATOM 13271 C ILE B 309 46.612 12.069 −27.563 1.00 22.75 B C ATOM 13272 O ILE B 309 45.645 11.896 −28.307 1.00 23.59 B O ATOM 13274 N ASP B 310 47.506 13.010 −27.796 1.00 22.88 B N ATOM 13275 CA ASP B 310 47.402 13.867 −28.991 1.00 24.17 B C ATOM 13277 CB ASP B 310 48.606 14.828 −29.062 1.00 25.25 B C ATOM 13280 CG ASP B 310 48.464 15.924 −30.125 1.00 31.57 B C ATOM 13281 OD1 ASP B 310 47.362 16.203 −30.614 1.00 41.50 B O ATOM 13282 OD2 ASP B 310 49.503 16.528 −30.461 1.00 46.26 B O ATOM 13283 C ASP B 310 47.268 13.005 −30.264 1.00 23.28 B C ATOM 13284 O ASP B 310 46.344 13.216 −31.032 1.00 22.28 B O ATOM 13286 N ASP B 311 48.139 12.012 −30.464 1.00 23.05 B N ATOM 13287 CA ASP B 311 48.040 11.175 −31.666 1.00 25.68 B C ATOM 13289 CB ASP B 311 49.146 10.136 −31.720 1.00 27.71 B C ATOM 13292 CG ASP B 311 50.509 10.741 −31.947 1.00 35.42 B C ATOM 13293 OD1 ASP B 311 50.567 11.862 −32.501 1.00 39.96 B O ATOM 13294 OD2 ASP B 311 51.516 10.092 −31.558 1.00 44.33 B O ATOM 13295 C ASP B 311 46.703 10.442 −31.770 1.00 24.73 B C ATOM 13296 O ASP B 311 46.168 10.275 −32.866 1.00 25.59 B O ATOM 13298 N ILE B 312 46.169 9.998 −30.640 1.00 21.14 B N ATOM 13299 CA ILE B 312 44.901 9.300 −30.658 1.00 20.46 B C ATOM 13301 CB ILE B 312 44.558 8.792 −29.225 1.00 21.25 B C ATOM 13303 CG1 ILE B 312 45.428 7.566 −28.870 1.00 22.56 B C ATOM 13306 CD1 ILE B 312 45.327 7.127 −27.386 1.00 15.81 B C ATOM 13310 CG2 ILE B 312 43.089 8.428 −29.087 1.00 17.97 B C ATOM 13314 C ILE B 312 43.803 10.213 −31.251 1.00 22.04 B C ATOM 13315 O ILE B 312 43.047 9.805 −32.119 1.00 21.87 B O ATOM 13317 N TYR B 313 43.700 11.445 −30.756 1.00 24.10 B N ATOM 13318 CA TYR B 313 42.717 12.413 −31.269 1.00 22.33 B C ATOM 13320 CB TYR B 313 42.602 13.613 −30.321 1.00 22.53 B C ATOM 13323 CG TYR B 313 41.860 13.350 −29.049 1.00 18.01 B C ATOM 13324 CD1 TYR B 313 40.533 13.713 −28.908 1.00 15.63 B C ATOM 13326 CE1 TYR B 313 39.838 13.478 −27.730 1.00 18.26 B C ATOM 13328 CZ TYR B 313 40.489 12.864 −26.664 1.00 22.61 B C ATOM 13329 OH TYR B 313 39.833 12.629 −25.474 1.00 18.89 B O ATOM 13331 CE2 TYR B 313 41.811 12.496 −26.785 1.00 23.65 B C ATOM 13333 CD2 TYR B 313 42.486 12.734 −27.977 1.00 22.64 B C ATOM 13335 C TYR B 313 43.080 12.921 −32.665 1.00 22.74 B C ATOM 13336 O TYR B 313 42.214 13.176 −33.481 1.00 22.56 B O ATOM 13338 N ASP B 314 44.365 13.066 −32.950 1.00 25.71 B N ATOM 13339 CA ASP B 314 44.768 13.652 −34.221 1.00 26.66 B C ATOM 13341 CB ASP B 314 46.227 14.059 −34.185 1.00 28.17 B C ATOM 13344 CG ASP B 314 46.668 14.758 −35.459 1.00 34.44 B C ATOM 13345 OD1 ASP B 314 45.874 15.565 −35.987 1.00 35.69 B O ATOM 13346 OD2 ASP B 314 47.809 14.501 −35.924 1.00 42.75 B O ATOM 13347 C ASP B 314 44.529 12.699 −35.409 1.00 26.37 B C ATOM 13348 O ASP B 314 43.935 13.112 −36.405 1.00 24.33 B O ATOM 13350 N VAL B 315 44.949 11.441 −35.282 1.00 24.78 B N ATOM 13351 CA VAL B 315 44.922 10.484 −36.415 1.00 25.23 B C ATOM 13353 CB VAL B 315 46.340 10.251 −36.987 1.00 23.87 B C ATOM 13355 CG1 VAL B 315 46.851 11.532 −37.688 1.00 27.00 B C ATOM 13359 CG2 VAL B 315 47.289 9.792 −35.902 1.00 22.09 B C ATOM 13363 C VAL B 315 44.305 9.096 −36.185 1.00 25.17 B C ATOM 13364 O VAL B 315 43.729 8.544 −37.109 1.00 27.94 B O ATOM 13366 N TYR B 316 44.426 8.520 −34.993 1.00 24.11 B N ATOM 13367 CA TYR B 316 44.020 7.122 −34.779 1.00 23.73 B C ATOM 13369 CB TYR B 316 44.867 6.522 −33.672 1.00 25.65 B C ATOM 13372 CG TYR B 316 44.824 5.019 −33.620 1.00 27.69 B C ATOM 13373 CD1 TYR B 316 45.597 4.235 −34.499 1.00 25.15 B C ATOM 13375 CE1 TYR B 316 45.550 2.814 −34.447 1.00 25.74 B C ATOM 13377 CZ TYR B 316 44.740 2.208 −33.503 1.00 24.05 B C ATOM 13378 OH TYR B 316 44.669 0.862 −33.392 1.00 25.86 B O ATOM 13380 CE2 TYR B 316 43.966 2.972 −32.630 1.00 31.18 B C ATOM 13382 CD2 TYR B 316 44.012 4.368 −32.692 1.00 27.68 B C ATOM 13384 C TYR B 316 42.540 6.883 −34.427 1.00 23.79 B C ATOM 13385 O TYR B 316 41.897 5.976 −34.977 1.00 23.24 B O ATOM 13387 N GLY B 317 41.999 7.665 −33.502 1.00 21.86 B N ATOM 13388 CA GLY B 317 40.677 7.383 −32.966 1.00 20.83 B C ATOM 13391 C GLY B 317 39.577 7.917 −33.858 1.00 23.66 B C ATOM 13392 O GLY B 317 39.701 9.008 −34.444 1.00 21.52 B O ATOM 13394 N THR B 318 38.490 7.152 −33.975 1.00 22.28 B N ATOM 13395 CA THR B 318 37.315 7.674 −34.607 1.00 22.27 B C ATOM 13397 CB THR B 318 36.314 6.564 −34.989 1.00 23.50 B C ATOM 13399 OG1 THR B 318 35.746 6.006 −33.803 1.00 25.49 B O ATOM 13401 CG2 THR B 318 37.006 5.456 −35.807 1.00 21.97 B C ATOM 13405 C THR B 318 36.625 8.610 −33.638 1.00 23.75 B C ATOM 13406 O THR B 318 36.823 8.542 −32.412 1.00 23.62 B O ATOM 13408 N LEU B 319 35.757 9.446 −34.189 1.00 22.45 B N ATOM 13409 CA LEU B 319 35.009 10.398 −33.393 1.00 24.74 B C ATOM 13411 CB LEU B 319 34.040 11.176 −34.274 1.00 24.05 B C ATOM 13414 CG LEU B 319 33.903 12.670 −34.012 1.00 34.66 B C ATOM 13416 CD1 LEU B 319 35.268 13.345 −33.825 1.00 22.94 B C ATOM 13420 CD2 LEU B 319 33.063 13.338 −35.150 1.00 33.27 B C ATOM 13424 C LEU B 319 34.273 9.736 −32.238 1.00 24.81 B C ATOM 13425 O LEU B 319 34.300 10.224 −31.127 1.00 27.70 B O ATOM 13427 N ASP B 320 33.637 8.605 −32.498 1.00 26.74 B N ATOM 13428 CA ASP B 320 32.910 7.881 −31.469 1.00 26.27 B C ATOM 13430 CB ASP B 320 32.192 6.650 −32.064 1.00 29.58 B C ATOM 13433 CG ASP B 320 30.855 6.977 −32.760 1.00 35.82 B C ATOM 13434 OD1 ASP B 320 30.397 8.145 −32.767 1.00 38.73 B O ATOM 13435 OD2 ASP B 320 30.261 6.018 −33.315 1.00 45.55 B O ATOM 13436 C ASP B 320 33.857 7.413 −30.361 1.00 23.93 B C ATOM 13437 O ASP B 320 33.509 7.435 −29.199 1.00 23.76 B O ATOM 13439 N GLU B 321 35.044 6.951 −30.724 1.00 23.54 B N ATOM 13440 CA GLU B 321 35.977 6.478 −29.721 1.00 22.08 B C ATOM 13442 CB GLU B 321 37.129 5.748 −30.378 1.00 21.78 B C ATOM 13445 CG GLU B 321 36.748 4.435 −31.077 1.00 21.27 B C ATOM 13448 CD GLU B 321 37.959 3.809 −31.762 1.00 25.99 B C ATOM 13449 OE1 GLU B 321 38.908 4.571 −32.114 1.00 24.28 B O ATOM 13450 OE2 GLU B 321 37.983 2.569 −31.922 1.00 26.77 B O ATOM 13451 C GLU B 321 36.506 7.668 −28.909 1.00 22.57 B C ATOM 13452 O GLU B 321 36.761 7.548 −27.714 1.00 21.71 B O ATOM 13454 N LEU B 322 36.665 8.813 −29.569 1.00 21.65 B N ATOM 13455 CA LEU B 322 37.187 9.993 −28.909 1.00 22.06 B C ATOM 13457 CB LEU B 322 37.611 11.059 −29.909 1.00 20.94 B C ATOM 13460 CG LEU B 322 38.692 10.615 −30.885 1.00 20.78 B C ATOM 13462 CD1 LEU B 322 38.999 11.683 −31.924 1.00 17.20 B C ATOM 13466 CD2 LEU B 322 39.949 10.199 −30.146 1.00 17.86 B C ATOM 13470 C LEU B 322 36.169 10.546 −27.927 1.00 23.46 B C ATOM 13471 O LEU B 322 36.555 11.005 −26.852 1.00 24.73 B O ATOM 13473 N GLU B 323 34.880 10.460 −28.243 1.00 21.53 B N ATOM 13474 CA GLU B 323 33.875 10.850 −27.261 1.00 23.97 B C ATOM 13476 CB GLU B 323 32.469 10.840 −27.851 1.00 26.47 B C ATOM 13479 CG GLU B 323 32.292 11.810 −29.011 1.00 31.79 B C ATOM 13482 CD GLU B 323 31.723 13.145 −28.600 1.00 39.43 B C ATOM 13483 OE1 GLU B 323 31.263 13.876 −29.515 1.00 44.91 B O ATOM 13484 OE2 GLU B 323 31.713 13.459 −27.383 1.00 40.00 B O ATOM 13485 C GLU B 323 33.930 9.940 −26.030 1.00 24.87 B C ATOM 13486 O GLU B 323 33.810 10.409 −24.899 1.00 23.87 B O ATOM 13488 N LEU B 324 34.129 8.643 −26.238 1.00 24.68 B N ATOM 13489 CA LEU B 324 34.224 7.719 −25.099 1.00 24.65 B C ATOM 13491 CB LEU B 324 34.330 6.249 −25.566 1.00 25.50 B C ATOM 13494 CG LEU B 324 33.033 5.612 −26.107 1.00 31.61 B C ATOM 13496 CD1 LEU B 324 33.328 4.286 −26.843 1.00 26.20 B C ATOM 13500 CD2 LEU B 324 32.020 5.401 −24.966 1.00 29.59 B C ATOM 13504 C LEU B 324 35.403 8.054 −24.199 1.00 22.74 B C ATOM 13505 O LEU B 324 35.294 7.976 −22.983 1.00 22.76 B O ATOM 13507 N PHE B 325 36.539 8.406 −24.794 1.00 21.75 B N ATOM 13508 CA PHE B 325 37.765 8.651 −24.017 1.00 19.99 B C ATOM 13510 CB PHE B 325 38.977 8.726 −24.943 1.00 18.14 B C ATOM 13513 CG PHE B 325 40.293 8.727 −24.222 1.00 20.43 B C ATOM 13514 CD1 PHE B 325 40.921 7.542 −23.911 1.00 20.73 B C ATOM 13516 CE1 PHE B 325 42.133 7.529 −23.250 1.00 18.54 B C ATOM 13518 CZ PHE B 325 42.741 8.712 −22.890 1.00 18.75 B C ATOM 13520 CE2 PHE B 325 42.129 9.912 −23.189 1.00 29.13 B C ATOM 13522 CD2 PHE B 325 40.901 9.918 −23.855 1.00 20.29 B C ATOM 13524 C PHE B 325 37.660 9.930 −23.215 1.00 19.39 B C ATOM 13525 O PHE B 325 38.067 9.999 −22.050 1.00 21.89 B O ATOM 13527 N THR B 326 37.153 10.956 −23.872 1.00 20.85 B N ATOM 13528 CA THR B 326 36.929 12.251 −23.274 1.00 21.29 B C ATOM 13530 CB THR B 326 36.274 13.175 −24.300 1.00 22.64 B C ATOM 13532 OG1 THR B 326 37.159 13.340 −25.420 1.00 21.93 B O ATOM 13534 CG2 THR B 326 35.978 14.532 −23.685 1.00 15.42 B C ATOM 13538 C THR B 326 36.034 12.107 −22.056 1.00 21.59 B C ATOM 13539 O THR B 326 36.334 12.624 −21.006 1.00 22.13 B O ATOM 13541 N ASP B 327 34.952 11.363 −22.213 1.00 25.12 B N ATOM 13542 CA ASP B 327 33.991 11.091 −21.144 1.00 24.52 B C ATOM 13544 CB ASP B 327 32.805 10.309 −21.729 1.00 26.23 B C ATOM 13547 CG ASP B 327 31.880 9.726 −20.654 1.00 35.17 B C ATOM 13548 OD1 ASP B 327 31.041 10.485 −20.095 1.00 38.22 B O ATOM 13549 OD2 ASP B 327 31.994 8.499 −20.370 1.00 41.20 B O ATOM 13550 C ASP B 327 34.635 10.320 −20.002 1.00 24.61 B C ATOM 13551 O ASP B 327 34.422 10.642 −18.824 1.00 25.19 B O ATOM 13553 N ALA B 328 35.440 9.313 −20.339 1.00 22.67 B N ATOM 13554 CA ALA B 328 36.152 8.535 −19.326 1.00 21.90 B C ATOM 13556 CB ALA B 328 36.923 7.388 −19.966 1.00 21.68 B C ATOM 13560 C ALA B 328 37.102 9.399 −18.487 1.00 21.10 B C ATOM 13561 O ALA B 328 37.245 9.183 −17.287 1.00 20.62 B O ATOM 13563 N VAL B 329 37.762 10.356 −19.118 1.00 18.66 B N ATOM 13564 CA VAL B 329 38.652 11.232 −18.405 1.00 18.17 B C ATOM 13566 CB VAL B 329 39.547 12.030 −19.362 1.00 18.54 B C ATOM 13568 CG1 VAL B 329 40.599 11.070 −20.002 1.00 20.31 B C ATOM 13572 CG2 VAL B 329 40.267 13.148 −18.630 1.00 16.84 B C ATOM 13576 C VAL B 329 37.841 12.144 −17.498 1.00 22.27 B C ATOM 13577 O VAL B 329 38.210 12.343 −16.342 1.00 24.05 B O ATOM 13579 N GLU B 330 36.725 12.664 −17.999 1.00 22.49 B N ATOM 13580 CA GLU B 330 35.830 13.499 −17.185 1.00 24.53 B C ATOM 13582 CB GLU B 330 34.638 14.006 −18.032 1.00 23.64 B C ATOM 13585 CG GLU B 330 35.054 15.060 −19.039 1.00 29.46 B C ATOM 13588 CD GLU B 330 33.972 15.467 −20.043 1.00 36.72 B C ATOM 13589 OE1 GLU B 330 34.141 16.536 −20.688 1.00 38.15 B O ATOM 13590 OE2 GLU B 330 32.969 14.739 −20.205 1.00 39.50 B O ATOM 13591 C GLU B 330 35.321 12.765 −15.952 1.00 25.12 B C ATOM 13592 O GLU B 330 35.371 13.295 −14.850 1.00 24.76 B O ATOM 13594 N ARG B 331 34.843 11.537 −16.129 1.00 26.13 B N ATOM 13595 CA AARG B 331 34.264 10.779 −15.016 0.50 25.43 B C ATOM 13596 CA BARG B 331 34.261 10.787 −15.019 0.50 25.52 B C ATOM 13599 CB AARG B 331 33.385 9.643 −15.539 0.50 25.68 B C ATOM 13600 CB BARG B 331 33.350 9.683 −15.563 0.50 25.87 B C ATOM 13605 CG AARG B 331 32.054 10.133 −16.144 0.50 29.23 B C ATOM 13606 CG BARG B 331 32.115 10.255 −16.312 0.50 29.59 B C ATOM 13611 CD AARG B 331 31.197 8.990 −16.686 0.50 32.54 B C ATOM 13612 CD BARG B 331 31.212 9.190 −16.943 0.50 32.56 B C ATOM 13617 NE AARG B 331 32.007 8.014 −17.403 0.50 39.07 B N ATOM 13618 NE BARG B 331 30.097 9.778 −17.691 0.50 37.34 B N ATOM 13621 CZ AARG B 331 32.223 6.766 −17.000 0.50 36.77 B C ATOM 13622 CZ BARG B 331 28.967 10.208 −17.135 0.50 40.94 B C ATOM 13623 NH1 AARG B 331 31.656 6.300 −15.886 0.50 38.70 B N ATOM 13624 NH1 BARG B 331 28.782 10.113 −15.825 0.50 38.56 B N ATOM 13629 NH2 AARG B 331 32.998 5.985 −17.733 0.50 33.12 B N ATOM 13630 NH2 BARG B 331 28.016 10.734 −17.891 0.50 39.98 B N ATOM 13635 C ARG B 331 35.327 10.245 −14.044 1.00 25.39 B C ATOM 13636 O ARG B 331 35.081 10.116 −12.841 1.00 23.54 B O ATOM 13638 N TRP B 332 36.509 9.935 −14.559 1.00 24.49 B N ATOM 13639 CA TRP B 332 37.622 9.451 −13.737 1.00 22.84 B C ATOM 13641 CB TRP B 332 38.153 10.576 −12.838 1.00 19.58 B C ATOM 13644 CG TRP B 332 39.557 10.379 −12.453 1.00 19.36 B C ATOM 13645 CD1 TRP B 332 40.027 9.997 −11.234 1.00 18.47 B C ATOM 13647 NE1 TRP B 332 41.393 9.903 −11.264 1.00 21.06 B N ATOM 13649 CE2 TRP B 332 41.831 10.202 −12.524 1.00 17.15 B C ATOM 13650 CD2 TRP B 332 40.701 10.503 −13.302 1.00 20.00 B C ATOM 13651 CE3 TRP B 332 40.875 10.827 −14.648 1.00 16.76 B C ATOM 13653 CZ3 TRP B 332 42.149 10.869 −15.154 1.00 18.63 B C ATOM 13655 CH2 TRP B 332 43.257 10.567 −14.354 1.00 21.96 B C ATOM 13657 CZ2 TRP B 332 43.115 10.241 −13.033 1.00 23.99 B C ATOM 13659 C TRP B 332 37.252 8.223 −12.919 1.00 21.89 B C ATOM 13660 O TRP B 332 37.517 8.160 −11.715 1.00 21.86 B O ATOM 13662 N ASP B 333 36.660 7.240 −13.591 1.00 22.25 B N ATOM 13663 CA ASP B 333 36.126 6.051 −12.932 1.00 24.19 B C ATOM 13665 CB ASP B 333 34.598 5.972 −13.154 1.00 24.72 B C ATOM 13668 CG ASP B 333 33.947 4.754 −12.473 1.00 28.67 B C ATOM 13669 OD1 ASP B 333 34.580 4.096 −11.612 1.00 32.90 B O ATOM 13670 OD2 ASP B 333 32.773 4.466 −12.795 1.00 34.32 B O ATOM 13671 C ASP B 333 36.796 4.790 −13.490 1.00 24.39 B C ATOM 13672 O ASP B 333 36.486 4.352 −14.599 1.00 23.16 B O ATOM 13674 N VAL B 334 37.673 4.183 −12.699 1.00 24.63 B N ATOM 13675 CA VAL B 334 38.392 3.011 −13.157 1.00 25.01 B C ATOM 13677 CB VAL B 334 39.571 2.670 −12.260 1.00 24.07 B C ATOM 13679 CG1 VAL B 334 40.484 1.692 −12.972 1.00 22.74 B C ATOM 13683 CG2 VAL B 334 39.094 2.132 −10.916 1.00 22.48 B C ATOM 13687 C VAL B 334 37.471 1.805 −13.298 1.00 28.84 B C ATOM 13688 O VAL B 334 37.724 0.960 −14.132 1.00 30.66 B O ATOM 13690 N ASN B 335 36.384 1.751 −12.530 1.00 30.57 B N ATOM 13691 CA ASN B 335 35.396 0.670 −12.667 1.00 32.76 B C ATOM 13693 CB ASN B 335 34.426 0.659 −11.474 1.00 32.97 B C ATOM 13696 CG ASN B 335 35.150 0.526 −10.136 1.00 36.11 B C ATOM 13697 OD1 ASN B 335 35.846 −0.464 −9.891 1.00 32.01 B O ATOM 13698 ND2 ASN B 335 35.002 1.537 −9.272 1.00 31.45 B N ATOM 13701 C ASN B 335 34.595 0.714 −13.973 1.00 33.61 B C ATOM 13702 O ASN B 335 33.783 −0.158 −14.187 1.00 32.20 B O ATOM 13704 N ALA B 336 34.819 1.725 −14.821 1.00 35.40 B N ATOM 13705 CA ALA B 336 34.165 1.832 −16.139 1.00 37.44 B C ATOM 13707 CB ALA B 336 33.391 3.153 −16.239 1.00 36.12 B C ATOM 13711 C ALA B 336 35.147 1.708 −17.306 1.00 37.97 B C ATOM 13712 O ALA B 336 34.797 1.970 −18.451 1.00 40.52 B O ATOM 13714 N ILE B 337 36.371 1.291 −17.006 1.00 39.74 B N ATOM 13715 CA ILE B 337 37.417 1.027 −18.010 1.00 39.19 B C ATOM 13717 CB ILE B 337 38.706 0.448 −17.308 1.00 40.69 B C ATOM 13719 CG1 ILE B 337 39.903 0.392 −18.237 1.00 45.92 B C ATOM 13722 CD1 ILE B 337 41.134 −0.183 −17.566 1.00 45.35 B C ATOM 13726 CG2 ILE B 337 38.488 −0.946 −16.773 1.00 38.80 B C ATOM 13730 C ILE B 337 36.959 0.093 −19.138 1.00 39.32 B C ATOM 13731 O ILE B 337 37.385 0.260 −20.278 1.00 39.83 B O ATOM 13733 N ASN B 338 36.080 −0.866 −18.837 1.00 37.82 B N ATOM 13734 CA ASN B 338 35.609 −1.831 −19.854 1.00 38.11 B C ATOM 13736 CB ASN B 338 34.944 −3.076 −19.201 1.00 37.75 B C ATOM 13739 CG ASN B 338 35.970 −4.092 −18.627 1.00 38.84 B C ATOM 13740 OD1 ASN B 338 37.163 −4.064 −18.937 1.00 33.79 B O ATOM 13741 ND2 ASN B 338 35.479 −5.010 −17.801 1.00 36.06 B N ATOM 13744 C ASN B 338 34.705 −1.253 −20.973 1.00 36.95 B C ATOM 13745 O ASN B 338 34.464 −1.915 −21.965 1.00 36.60 B O ATOM 13747 N ASP B 339 34.243 −0.019 −20.839 1.00 37.98 B N ATOM 13748 CA ASP B 339 33.479 0.647 −21.920 1.00 38.56 B C ATOM 13750 CB ASP B 339 32.804 1.938 −21.394 1.00 40.02 B C ATOM 13753 CG ASP B 339 31.899 1.706 −20.161 1.00 44.52 B C ATOM 13754 OD1 ASP B 339 31.430 0.568 −19.940 1.00 49.31 B O ATOM 13755 OD2 ASP B 339 31.641 2.690 −19.430 1.00 45.68 B O ATOM 13756 C ASP B 339 34.381 1.036 −23.110 1.00 34.68 B C ATOM 13757 O ASP B 339 33.918 1.279 −24.221 1.00 34.99 B O ATOM 13759 N LEU B 340 35.674 1.116 −22.855 1.00 31.43 B N ATOM 13760 CA LEU B 340 36.619 1.597 −23.846 1.00 29.09 B C ATOM 13762 CB LEU B 340 37.803 2.257 −23.138 1.00 27.62 B C ATOM 13765 CG LEU B 340 37.483 3.472 −22.279 1.00 26.44 B C ATOM 13767 CD1 LEU B 340 38.682 3.873 −21.426 1.00 20.10 B C ATOM 13771 CD2 LEU B 340 37.050 4.595 −23.174 1.00 24.57 B C ATOM 13775 C LEU B 340 37.145 0.464 −24.725 1.00 25.95 B C ATOM 13776 O LEU B 340 37.281 −0.666 −24.260 1.00 26.50 B O ATOM 13778 N PRO B 341 37.472 0.773 −25.984 1.00 24.08 B N ATOM 13779 CA PRO B 341 38.167 −0.187 −26.836 1.00 24.62 B C ATOM 13781 CB PRO B 341 38.191 0.493 −28.218 1.00 24.85 B C ATOM 13784 CG PRO B 341 38.063 1.910 −27.954 1.00 26.60 B C ATOM 13787 CD PRO B 341 37.281 2.065 −26.661 1.00 25.30 B C ATOM 13790 C PRO B 341 39.564 −0.443 −26.320 1.00 23.26 B C ATOM 13791 O PRO B 341 40.103 0.360 −25.544 1.00 21.32 B O ATOM 13792 N ASP B 342 40.134 −1.571 −26.725 1.00 23.87 B N ATOM 13793 CA ASP B 342 41.289 −2.122 −26.026 1.00 23.29 B C ATOM 13795 CB ASP B 342 41.767 −3.425 −26.696 1.00 25.56 B C ATOM 13798 CG ASP B 342 40.790 −4.605 −26.491 1.00 31.22 B C ATOM 13799 OD1 ASP B 342 39.943 −4.549 −25.566 1.00 32.95 B O ATOM 13800 OD2 ASP B 342 40.889 −5.599 −27.254 1.00 37.04 B O ATOM 13801 C ASP B 342 42.436 −1.120 −25.929 1.00 22.80 B C ATOM 13802 O ASP B 342 43.042 −0.938 −24.845 1.00 21.42 B O ATOM 13804 N TYR B 343 42.747 −0.457 −27.039 1.00 20.42 B N ATOM 13805 CA TYR B 343 43.912 0.428 −27.038 1.00 20.57 B C ATOM 13807 CB TYR B 343 44.273 0.888 −28.460 1.00 20.66 B C ATOM 13810 CG TYR B 343 43.398 1.977 −29.041 1.00 23.23 B C ATOM 13811 CD1 TYR B 343 42.233 1.680 −29.747 1.00 20.78 B C ATOM 13813 CE1 TYR B 343 41.441 2.700 −30.274 1.00 26.89 B C ATOM 13815 CZ TYR B 343 41.836 4.026 −30.103 1.00 23.64 B C ATOM 13816 OH TYR B 343 41.124 5.055 −30.630 1.00 26.31 B O ATOM 13818 CE2 TYR B 343 42.993 4.332 −29.437 1.00 22.44 B C ATOM 13820 CD2 TYR B 343 43.765 3.316 −28.910 1.00 23.71 B C ATOM 13822 C TYR B 343 43.689 1.603 −26.069 1.00 20.00 B C ATOM 13823 O TYR B 343 44.602 2.031 −25.396 1.00 18.99 B O ATOM 13825 N MET B 344 42.459 2.080 −25.966 1.00 20.82 B N ATOM 13826 CA MET B 344 42.145 3.158 −25.030 1.00 20.77 B C ATOM 13828 CB MET B 344 40.819 3.806 −25.392 1.00 20.51 B C ATOM 13831 CG MET B 344 40.953 4.773 −26.564 1.00 21.38 B C ATOM 13834 SD MET B 344 39.418 5.528 −27.088 1.00 22.33 B S ATOM 13835 CE MET B 344 40.022 6.860 −28.132 1.00 16.19 B C ATOM 13839 C MET B 344 42.134 2.677 −23.591 1.00 22.13 B C ATOM 13840 O MET B 344 42.497 3.420 −22.682 1.00 20.90 B O ATOM 13842 N LYS B 345 41.731 1.427 −23.402 1.00 23.38 B N ATOM 13843 CA LYS B 345 41.726 0.791 −22.077 1.00 24.79 B C ATOM 13845 CB LYS B 345 41.476 −0.712 −22.211 1.00 27.00 B C ATOM 13848 CG LYS B 345 40.331 −1.290 −21.421 1.00 35.72 B C ATOM 13851 CD LYS B 345 39.732 −2.426 −22.257 1.00 37.84 B C ATOM 13854 CE LYS B 345 38.753 −3.251 −21.507 1.00 39.59 B C ATOM 13857 NZ LYS B 345 37.824 −3.918 −22.467 1.00 43.84 B N ATOM 13861 C LYS B 345 43.082 0.957 −21.458 1.00 21.39 B C ATOM 13862 O LYS B 345 43.214 1.460 −20.349 1.00 21.62 B O ATOM 13864 N LEU B 346 44.086 0.500 −22.192 1.00 19.29 B N ATOM 13865 CA LEU B 346 45.449 0.496 −21.723 1.00 20.97 B C ATOM 13867 CB LEU B 346 46.322 −0.210 −22.743 1.00 21.36 B C ATOM 13870 CG LEU B 346 47.675 −0.639 −22.223 1.00 23.78 B C ATOM 13872 CD1 LEU B 346 47.477 −1.675 −21.112 1.00 20.34 B C ATOM 13876 CD2 LEU B 346 48.444 −1.253 −23.370 1.00 27.71 B C ATOM 13880 C LEU B 346 45.958 1.908 −21.486 1.00 21.00 B C ATOM 13881 O LEU B 346 46.523 2.225 −20.433 1.00 21.92 B O ATOM 13883 N CYS B 347 45.753 2.763 −22.469 1.00 19.96 B N ATOM 13884 CA CYS B 347 46.241 4.139 −22.383 1.00 21.49 B C ATOM 13886 CB CYS B 347 45.945 4.847 −23.725 1.00 23.29 B C ATOM 13889 SG CYS B 347 46.580 6.488 −23.807 1.00 37.91 B S ATOM 13891 C CYS B 347 45.571 4.880 −21.211 1.00 19.02 B C ATOM 13892 O CYS B 347 46.215 5.622 −20.460 1.00 16.76 B O ATOM 13894 N PHE B 348 44.271 4.649 −21.038 1.00 18.76 B N ATOM 13895 CA PHE B 348 43.529 5.306 −19.983 1.00 18.67 B C ATOM 13897 CB PHE B 348 42.035 5.009 −20.055 1.00 17.98 B C ATOM 13900 CG PHE B 348 41.269 5.635 −18.939 1.00 17.07 B C ATOM 13901 CD1 PHE B 348 41.030 6.990 −18.933 1.00 21.41 B C ATOM 13903 CE1 PHE B 348 40.352 7.592 −17.885 1.00 23.96 B C ATOM 13905 CZ PHE B 348 39.939 6.844 −16.815 1.00 21.12 B C ATOM 13907 CE2 PHE B 348 40.191 5.484 −16.803 1.00 22.43 B C ATOM 13909 CD2 PHE B 348 40.867 4.894 −17.855 1.00 21.94 B C ATOM 13911 C PHE B 348 44.032 4.868 −18.616 1.00 18.84 B C ATOM 13912 O PHE B 348 44.286 5.700 −17.738 1.00 17.72 B O ATOM 13914 N LEU B 349 44.174 3.562 −18.429 1.00 17.46 B N ATOM 13915 CA LEU B 349 44.520 3.063 −17.118 1.00 18.56 B C ATOM 13917 CB LEU B 349 44.388 1.545 −17.053 1.00 19.12 B C ATOM 13920 CG LEU B 349 44.690 0.832 −15.727 1.00 19.64 B C ATOM 13922 CD1 LEU B 349 44.000 1.519 −14.535 1.00 13.56 B C ATOM 13926 CD2 LEU B 349 44.259 −0.634 −15.855 1.00 11.45 B C ATOM 13930 C LEU B 349 45.926 3.532 −16.771 1.00 19.38 B C ATOM 13931 O LEU B 349 46.196 3.873 −15.620 1.00 16.91 B O ATOM 13933 N ALA B 350 46.810 3.590 −17.774 1.00 21.32 B N ATOM 13934 CA ALA B 350 48.189 4.094 −17.560 1.00 20.38 B C ATOM 13936 CB ALA B 350 49.004 3.959 −18.854 1.00 20.36 B C ATOM 13940 C ALA B 350 48.232 5.538 −17.068 1.00 17.92 B C ATOM 13941 O ALA B 350 48.948 5.872 −16.148 1.00 15.97 B O ATOM 13943 N LEU B 351 47.493 6.400 −17.747 1.00 19.62 B N ATOM 13944 CA LEU B 351 47.334 7.796 −17.357 1.00 18.33 B C ATOM 13946 CB LEU B 351 46.440 8.505 −18.390 1.00 21.12 B C ATOM 13949 CG LEU B 351 46.123 9.988 −18.131 1.00 23.41 B C ATOM 13951 CD1 LEU B 351 47.364 10.823 −18.236 1.00 19.59 B C ATOM 13955 CD2 LEU B 351 45.052 10.462 −19.098 1.00 22.85 B C ATOM 13959 C LEU B 351 46.694 7.924 −15.972 1.00 18.87 B C ATOM 13960 O LEU B 351 47.165 8.709 −15.117 1.00 19.16 B O ATOM 13962 N TYR B 352 45.604 7.176 −15.780 1.00 16.72 B N ATOM 13963 CA TYR B 352 44.870 7.128 −14.520 1.00 16.75 B C ATOM 13965 CB TYR B 352 43.799 6.040 −14.614 1.00 18.50 B C ATOM 13968 CG TYR B 352 42.765 5.984 −13.519 1.00 17.16 B C ATOM 13969 CD1 TYR B 352 41.688 6.868 −13.514 1.00 22.74 B C ATOM 13971 CE1 TYR B 352 40.702 6.807 −12.524 1.00 21.64 B C ATOM 13973 CZ TYR B 352 40.788 5.858 −11.535 1.00 21.98 B C ATOM 13974 OH TYR B 352 39.800 5.795 −10.560 1.00 25.58 B O ATOM 13976 CE2 TYR B 352 41.861 4.956 −11.528 1.00 19.79 B C ATOM 13978 CD2 TYR B 352 42.828 5.022 −12.524 1.00 17.06 B C ATOM 13980 C TYR B 352 45.801 6.835 −13.363 1.00 16.79 B C ATOM 13981 O TYR B 352 45.874 7.601 −12.384 1.00 17.65 B O ATOM 13983 N ASN B 353 46.534 5.734 −13.460 1.00 16.33 B N ATOM 13984 CA ASN B 353 47.437 5.356 −12.361 1.00 18.36 B C ATOM 13986 CB ASN B 353 48.058 3.995 −12.629 1.00 15.27 B C ATOM 13989 CG ASN B 353 47.068 2.864 −12.502 1.00 19.46 B C ATOM 13990 OD1 ASN B 353 45.965 3.037 −11.982 1.00 17.65 B O ATOM 13991 ND2 ASN B 353 47.463 1.677 −12.969 1.00 15.56 B N ATOM 13994 C ASN B 353 48.538 6.420 −12.127 1.00 18.63 B C ATOM 13995 O ASN B 353 48.930 6.688 −10.994 1.00 13.58 B O ATOM 13997 N THR B 354 49.012 7.047 −13.210 1.00 19.49 B N ATOM 13998 CA THR B 354 50.102 7.999 −13.110 1.00 17.67 B C ATOM 14000 CB THR B 354 50.610 8.406 −14.501 1.00 20.08 B C ATOM 14002 OG1 THR B 354 51.004 7.243 −15.238 1.00 18.36 B O ATOM 14004 CG2 THR B 354 51.789 9.381 −14.389 1.00 17.15 B C ATOM 14008 C THR B 354 49.634 9.239 −12.347 1.00 18.15 B C ATOM 14009 O THR B 354 50.316 9.713 −11.462 1.00 18.88 B O ATOM 14011 N ILE B 355 48.454 9.728 −12.694 1.00 16.69 B N ATOM 14012 CA ILE B 355 47.908 10.920 −12.095 1.00 17.85 B C ATOM 14014 CB ILE B 355 46.657 11.416 −12.875 1.00 18.34 B C ATOM 14016 CG1 ILE B 355 46.999 11.833 −14.317 1.00 21.17 B C ATOM 14019 CD1 ILE B 355 48.356 12.354 −14.519 1.00 25.46 B C ATOM 14023 CG2 ILE B 355 45.993 12.558 −12.164 1.00 19.09 B C ATOM 14027 C ILE B 355 47.550 10.632 −10.630 1.00 17.55 B C ATOM 14028 O ILE B 355 47.954 11.376 −9.729 1.00 14.98 B O ATOM 14030 N ASN B 356 46.806 9.557 −10.387 1.00 17.07 B N ATOM 14031 CA ASN B 356 46.532 9.152 −9.008 1.00 18.16 B C ATOM 14033 CB ASN B 356 45.687 7.874 −8.941 1.00 17.23 B C ATOM 14036 CG ASN B 356 44.314 8.080 −9.531 1.00 17.52 B C ATOM 14037 OD1 ASN B 356 43.925 9.217 −9.798 1.00 25.68 B O ATOM 14038 ND2 ASN B 356 43.592 7.004 −9.782 1.00 19.09 B N ATOM 14041 C ASN B 356 47.783 9.003 −8.161 1.00 19.24 B C ATOM 14042 O ASN B 356 47.765 9.283 −6.975 1.00 22.07 B O ATOM 14044 N GLU B 357 48.885 8.596 −8.752 1.00 21.23 B N ATOM 14045 CA GLU B 357 50.112 8.425 −7.967 1.00 19.96 B C ATOM 14047 CB GLU B 357 51.064 7.495 −8.708 1.00 18.90 B C ATOM 14050 CG GLU B 357 52.445 7.346 −8.117 1.00 34.11 B C ATOM 14053 CD GLU B 357 53.308 6.403 −8.934 1.00 49.89 B C ATOM 14054 OE1 GLU B 357 54.545 6.565 −8.899 1.00 54.67 B O ATOM 14055 OE2 GLU B 357 52.742 5.520 −9.630 1.00 62.79 B O ATOM 14056 C GLU B 357 50.738 9.782 −7.660 1.00 18.63 B C ATOM 14057 O GLU B 357 51.308 9.983 −6.589 1.00 17.61 B O ATOM 14059 N ILE B 358 50.625 10.741 −8.571 1.00 20.13 B N ATOM 14060 CA ILE B 358 51.074 12.094 −8.246 1.00 19.81 B C ATOM 14062 CB ILE B 358 51.160 12.978 −9.495 1.00 23.03 B C ATOM 14064 CG1 ILE B 358 52.286 12.481 −10.418 1.00 23.28 B C ATOM 14067 CD1 ILE B 358 52.104 12.900 −11.898 1.00 17.88 B C ATOM 14071 CG2 ILE B 358 51.438 14.454 −9.111 1.00 18.37 B C ATOM 14075 C ILE B 358 50.150 12.692 −7.164 1.00 19.64 B C ATOM 14076 O ILE B 358 50.621 13.279 −6.196 1.00 18.49 B O ATOM 14078 N ALA B 359 48.835 12.505 −7.298 1.00 21.04 B N ATOM 14079 CA ALA B 359 47.910 12.942 −6.247 1.00 19.40 B C ATOM 14081 CB ALA B 359 46.510 12.504 −6.556 1.00 16.36 B C ATOM 14085 C ALA B 359 48.371 12.364 −4.920 1.00 21.14 B C ATOM 14086 O ALA B 359 48.372 13.050 −3.874 1.00 22.13 B O ATOM 14088 N TYR B 360 48.815 11.108 −4.955 1.00 19.16 B N ATOM 14089 CA TYR B 360 49.215 10.452 −3.712 1.00 18.42 B C ATOM 14091 CB TYR B 360 49.446 8.947 −3.887 1.00 15.75 B C ATOM 14094 CG TYR B 360 49.888 8.307 −2.601 1.00 12.33 B C ATOM 14095 CD1 TYR B 360 48.972 7.920 −1.649 1.00 13.40 B C ATOM 14097 CE1 TYR B 360 49.371 7.368 −0.458 1.00 9.59 B C ATOM 14099 CZ TYR B 360 50.716 7.214 −0.194 1.00 15.43 B C ATOM 14100 OH TYR B 360 51.132 6.646 1.000 1.00 13.06 B O ATOM 14102 CE2 TYR B 360 51.646 7.606 −1.132 1.00 12.26 B C ATOM 14104 CD2 TYR B 360 51.233 8.143 −2.315 1.00 12.87 B C ATOM 14106 C TYR B 360 50.424 11.100 −3.604 1.00 16.88 B C ATOM 14107 O TYR B 360 50.434 11.292 −1.857 1.00 16.26 B O ATOM 14109 N ASP B 361 51.445 11.406 −3.855 1.00 19.15 B N ATOM 14110 CA ASP B 361 52.668 12.027 −3.354 1.00 20.70 B C ATOM 14112 CB ASP B 361 53.668 12.338 −4.492 1.00 22.88 B C ATOM 14115 CG ASP B 361 54.242 11.079 −5.177 1.00 30.52 B C ATOM 14116 OD1 ASP B 361 54.385 10.017 −4.519 1.00 34.4 B O ATOM 14117 OD2 ASP B 361 54.556 11.171 −6.382 1.00 37.22 B O ATOM 14118 C ASP B 361 52.319 13.350 −2.676 1.00 22.70 B C ATOM 14119 O ASP B 361 52.856 13.697 −1.635 1.00 21.32 B O ATOM 14121 N ASN B 362 51.427 14.097 −3.308 1.00 22.85 B N ATOM 14122 CA ASN B 362 50.995 15.345 −2.761 1.00 23.65 B C ATOM 14124 CB ASN B 3362 50.210 16.111 −3.804 1.00 25.00 B C ATOM 14127 CG ASN B 362 51.100 16.886 −4.672 1.00 30.68 B C ATOM 14128 OD1 ASN B 362 51.508 17.995 −4.301 1.00 29.31 B O ATOM 14129 ND2 ASN B 362 51.492 16.295 −5.823 1.00 34.07 B N ATOM 14132 C ASN B 362 50.178 15.225 −1.495 1.00 22.70 B C ATOM 14133 O ASN B 362 50.337 16.038 −0.590 1.00 22.27 B O ATOM 14135 N LEU B 363 49.292 14.249 −1.438 1.00 20.22 B N ATOM 14136 CA LEU B 363 48.564 14.000 −0.210 1.00 20.99 B C ATOM 14138 CB LEU B 363 47.544 12.874 −0.388 1.00 19.03 B C ATOM 14141 CG LEU B 363 46.668 12.477 0.809 1.00 22.46 B C ATOM 14143 CD1 LEU B 363 45.834 13.657 1.352 1.00 16.50 B C ATOM 14147 CD2 LEU B 363 45.75 11.304 0.456 1.00 15.67 B C ATOM 14151 C LEU B 363 49.582 13.669 0.868 1.00 21.81 B C ATOM 14152 O LEU B 363 49.546 14.234 1.950 1.00 22.89 B O ATOM 14154 N LYS B 364 50.531 12.798 0.558 1.00 24.05 B N ATOM 14155 CA LYS B 364 51.494 12.362 1.566 1.00 24.81 B C ATOM 14157 CB LYS B 364 52.416 11.272 1.015 1.00 24.82 B C ATOM 14160 CG LYS B 364 53.281 10.584 2.058 1.00 27.90 B C ATOM 14163 CD LYS B 364 54.170 9.479 1.430 1.00 31.07 B C ATOM 14166 CE LYS B 364 55.496 9.983 0.869 1.00 27.35 B C ATOM 14169 NZ LYS B 364 55.461 10.244 −0.578 1.00 39.19 B N ATOM 14173 C LYS B 364 52.340 13.526 2.066 1.00 26.11 B C ATOM 14174 O LYS B 364 52.554 13.650 3.281 1.00 23.11 B O ATOM 14176 N ASP B 365 52.838 14.349 1.133 1.00 25.89 B N ATOM 14177 CA ASP B 365 53.864 15.347 1.466 1.00 29.64 B C ATOM 14179 CB ASP B 365 54.815 15.590 0.286 1.00 31.01 B C ATOM 14182 CG ASP B 365 55.574 14.334 −0.135 1.00 40.18 B C ATOM 14183 OD1 ASP B 365 55.800 13.438 0.719 1.00 43.63 B C ATOM 14184 OD2 ASP B 365 55.939 14.257 −1.336 1.00 47.50 B O ATOM 14185 C ASP B 365 53.276 16.680 1.907 1.00 29.07 B C ATOM 14186 O ASP B 365 53.883 17.378 2.696 1.00 31.54 B O ATOM 14188 N LYS B 366 52.104 17.028 1.395 1.00 28.84 B N ATOM 14189 CA LYS B 366 51.490 18.322 1.681 1.00 31.06 B C ATOM 14191 CB LYS B 366 51.269 19.114 0.382 1.00 31.40 B C ATOM 14194 CG LYS B 366 52.545 19.404 −0.401 1.00 37.02 B C ATOM 14197 CD LYS B 366 52.242 20.235 −1.658 1.00 53.13 B C ATOM 14200 CE LYS B 366 53.336 20.108 −2.732 1.00 53.38 B C ATOM 14203 NZ LYS B 366 54.714 20.334 −2.185 1.00 64.76 B N ATOM 14207 C LYS B 366 50.172 18.210 2.446 1.00 31.50 B C ATOM 14208 O LYS B 366 49.653 19.220 2.915 1.00 33.61 B O ATOM 14210 N GLY B 367 49.631 17.002 2.579 1.00 28.68 B N ATOM 14211 CA GLY B 367 48.409 16.804 3.338 1.00 27.28 B C ATOM 14214 C GLY B 367 47.191 17.406 2.685 1.00 27.99 B C ATOM 14215 O GLY B 367 46.250 17.788 3.386 1.00 28.42 B O ATOM 14217 N GLU B 368 47.203 17.468 1.347 1.00 27.86 B N ATOM 14218 CA GLU B 368 46.081 17.979 0.547 1.00 27.52 B C ATOM 14220 CB GLU B 368 46.450 19.330 −0.095 1.00 30.43 B C ATOM 14223 CG GLU B 368 46.948 20.426 0.862 1.00 39.15 B C ATOM 14226 CD GLU B 368 45.836 21.137 1.619 1.00 47.36 B C ATOM 14227 OE1 GLU B 368 44.658 20.703 1.548 1.00 49.41 B O ATOM 14228 OE2 GLU B 368 46.162 22.142 2.291 1.00 53.64 B O ATOM 14229 C GLU B 368 45.713 17.032 −0.591 1.00 24.33 B C ATOM 14230 O GLU B 368 46.584 16.536 −1.308 1.00 22.31 B O ATOM 14232 N ASN B 369 44.421 16.800 −0.764 1.00 23.20 B N ATOM 14233 CA ASN B 369 43.909 16.123 −1.947 1.00 23.98 B C ATOM 14235 CB ASN B 369 42.532 15.541 −1.671 1.00 23.61 B C ATOM 14238 CG ASN B 369 42.019 14.665 −2.820 1.00 28.43 B C ATOM 14239 OD1 ASN B 369 42.646 14.562 −3.880 1.00 27.91 B O ATOM 14240 ND2 ASN B 369 40.871 14.015 −2.597 1.00 22.66 B N ATOM 14243 C ASN B 369 43.806 17.093 −3.129 1.00 23.36 B C ATOM 14244 O ASN B 369 42.863 17.874 −3.200 1.00 24.65 B O ATOM 14246 N ILE B 370 44.751 17.015 −4.059 1.00 21.14 B N ATOM 14247 CA ILE B 370 44.723 17.849 −5.249 1.00 21.55 B C ATOM 14249 CB ILE B 370 46.137 18.417 −5.572 1.00 22.76 B C ATOM 14251 CG1 ILE B 370 47.140 17.296 −5.847 1.00 22.92 B C ATOM 14254 CD1 ILE B 370 48.345 17.766 −6.586 1.00 25.13 B C ATOM 14258 CG2 ILE B 370 46.639 19.311 −4.433 1.00 21.02 B C ATOM 14262 C ILE B 370 44.180 17.118 −6.492 1.00 22.16 B C ATOM 14263 O ILE B 370 44.222 17.661 −7.593 1.00 21.34 B O ATOM 14265 N LEU B 371 43.669 15.898 −6.330 1.00 20.03 B N ATOM 14266 CA LEU B 371 43.260 15.105 −7.485 1.00 20.80 B C ATOM 14268 CB LEU B 371 42.735 13.735 −7.052 1.00 19.94 B C ATOM 14271 CG LEU B 371 42.452 12.746 −8.191 1.00 22.27 B C ATOM 14273 CD1 LEU B 371 43.736 12.396 −8.973 1.00 16.64 B C ATOM 14277 CD2 LEU B 371 41.792 11.477 −7.642 1.00 18.00 B C ATOM 14281 C LEU B 371 42.219 15.800 −8.387 1.00 22.85 B C ATOM 14282 O LEU B 371 42.340 15.738 −9.623 1.00 24.00 B O ATOM 14284 N PRO B 372 41.201 16.468 −7.787 1.00 23.30 B N ATOM 14285 CA PRO B 372 40.201 17.090 −8.648 1.00 23.58 B C ATOM 14287 CB PRO B 372 39.225 17.761 −7.670 1.00 24.01 B C ATOM 14290 CG PRO B 372 39.457 17.118 −6.376 1.00 28.41 B C ATOM 14293 CD PRO B 372 40.897 16.685 −6.359 1.00 25.80 B C ATOM 14296 C PRO B 372 40.804 18.105 −9.604 1.00 22.18 B C ATOM 14297 O PRO B 372 40.310 18.227 −10.701 1.00 23.54 B O ATOM 14298 N TYR B 373 41.867 18.790 −9.195 1.00 21.49 B N ATOM 14299 CA TYR B 373 42.552 19.781 −10.047 1.00 24.02 B C ATOM 14301 CB TYR B 373 43.456 20.714 −9.213 1.00 25.06 B C ATOM 14304 CG TYR B 373 42.747 21.255 −7.971 1.00 28.99 B C ATOM 14305 CD1 TYR B 373 41.617 22.058 −8.083 1.00 37.98 B C ATOM 14307 CE1 TYR B 373 40.932 22.510 −6.958 1.00 38.97 B C ATOM 14309 CZ TYR B 373 41.378 22.165 −5.709 1.00 40.12 B C ATOM 14310 OH TYR B 373 40.713 22.610 −4.589 1.00 48.27 B O ATOM 14312 CE2 TYR B 373 42.488 21.359 −5.568 1.00 40.83 B C ATOM 14314 CD2 TYR B 373 43.160 20.898 −6.702 1.00 33.96 B C ATOM 14316 C TYR B 373 43.366 19.107 −11.147 1.00 25.44 B C ATOM 14317 O TYR B 373 43.388 19.591 −12.283 1.00 26.29 B O ATOM 14319 N LEU B 374 44.013 17.980 −10.834 1.00 24.17 B N ATOM 14320 CA LEU B 374 44.808 17.285 −11.844 1.00 20.73 B C ATOM 14322 CB LEU B 374 45.721 16.236 −11.224 1.00 20.86 B C ATOM 14325 CG LEU B 374 46.684 16.702 −10.130 1.00 20.24 B C ATOM 14327 CD1 LEU B 374 47.543 15.508 −9.612 1.00 16.80 B C ATOM 14331 CD2 LEU B 374 47.562 17.841 −10.572 1.00 17.67 B C ATOM 14335 C LEU B 374 43.891 16.659 −12.869 1.00 18.95 B C ATOM 14336 O LEU B 374 44.166 16.700 −14.059 1.00 20.39 B O ATOM 14338 N THR B 375 42.772 16.107 −12.439 1.00 20.66 B N ATOM 14339 CA THR B 375 41.896 15.466 −13.399 1.00 19.66 B C ATOM 14341 CB THR B 375 40.958 14.480 −12.726 1.00 21.51 B C ATOM 14343 OG1 THR B 375 40.128 15.161 −11.787 1.00 22.47 B O ATOM 14345 CG2 THR B 375 41.788 13.374 −12.020 1.00 15.76 B C ATOM 14349 C THR B 375 41.130 16.486 −14.248 1.00 22.51 B C ATOM 14350 O THR B 375 40.859 16.249 −15.429 1.00 23.67 B O ATOM 14352 N LYS B 376 40.798 17.631 −13.670 1.00 23.19 B N ATOM 14353 CA LYS B 376 40.133 18.683 −14.434 1.00 24.29 B C ATOM 14355 CB LYS B 376 39.727 19.837 −13.517 1.00 25.69 B C ATOM 14358 CG LYS B 376 38.961 20.963 −14.212 1.00 32.29 B C ATOM 14361 CD LYS B 376 37.580 20.536 −14.716 1.00 36.20 B C ATOM 14364 CE LYS B 376 36.881 21.706 −15.449 1.00 39.50 B C ATOM 14367 NZ LYS B 376 35.532 21.322 −15.952 1.00 46.03 B N ATOM 14371 C LYS B 376 41.050 19.181 −15.535 1.00 21.89 B C ATOM 14372 O LYS B 376 40.614 19.403 −16.653 1.00 24.65 B O ATOM 14374 N ALA B 377 42.325 19.356 −15.222 1.00 20.03 B N ATOM 14375 CA ALA B 377 43.294 19.765 −16.228 1.00 18.15 B C ATOM 14377 CB ALA B 377 44.692 19.870 −15.637 1.00 18.15 B C ATOM 14381 C ALA B 377 43.283 18.775 −17.366 1.00 18.11 B C ATOM 14382 O ALA B 377 43.257 19.189 −18.533 1.00 18.41 B O ATOM 14384 N TRP B 378 43.258 17.473 −17.059 1.00 17.59 B N ATOM 14385 CA TRP B 378 43.221 16.492 −18.146 1.00 19.76 B C ATOM 14387 CB TRP B 378 43.567 15.063 −17.701 1.00 20.21 B C ATOM 14390 CG TRP B 378 45.032 14.853 −17.733 1.00 19.57 B C ATOM 14391 CD1 TRP B 378 45.905 14.995 −16.696 1.00 16.98 B C ATOM 14393 NE1 TRP B 378 47.183 14.779 −17.128 1.00 19.55 B N ATOM 14395 CE2 TRP B 378 47.152 14.483 −18.466 1.00 17.20 B C ATOM 14396 CD2 TRP B 378 45.816 14.528 −18.878 1.00 17.73 B C ATOM 14397 CE3 TRP B 378 45.512 14.282 −20.216 1.00 19.66 B C ATOM 14399 CZ3 TRP B 378 46.530 13.995 −21.082 1.00 21.97 B C ATOM 14401 CH2 TRP B 378 47.851 13.935 −20.644 1.00 21.81 B C ATOM 14403 CZ2 TRP B 378 48.188 14.197 −19.340 1.00 20.44 B C ATOM 14405 C TRP B 378 41.919 16.552 −18.924 1.00 19.35 B C ATOM 14406 O TRP B 378 41.929 16.331 −20.136 1.00 20.96 B O ATOM 14408 N ALA B 379 40.821 16.846 −18.242 1.00 17.74 B N ATOM 14409 CA ALA B 379 39.499 16.867 −18.893 1.00 20.62 B C ATOM 14411 CB ALA B 379 38.337 17.003 −17.854 1.00 20.87 B C ATOM 14415 C ALA B 379 39.443 18.014 −19.877 1.00 20.85 B C ATOM 14416 O ALA B 379 38.957 17.853 −20.998 1.00 22.78 B O ATOM 14418 N ASP B 380 39.966 19.164 −19.467 1.00 19.02 B N ATOM 14419 CA ASP B 380 40.048 20.318 −20.354 1.00 20.32 B C ATOM 14421 CB ASP B 380 40.580 21.538 −19.611 1.00 22.48 B C ATOM 14424 CG ASP B 380 39.628 22.029 −18.535 1.00 22.07 B C ATOM 14425 OD1 ASP B 380 38.441 21.626 −18.530 1.00 25.90 B O ATOM 14426 OD2 ASP B 380 40.081 22.808 −17.697 1.00 25.80 B O ATOM 14427 C ASP B 380 40.920 20.075 −21.561 1.00 20.78 B C ATOM 14428 O ASP B 380 40.604 20.529 −22.650 1.00 24.69 B O ATOM 14430 N LEU B 381 42.016 19.361 −21.385 1.00 20.48 B N ATOM 14431 CA LEU B 381 42.894 19.074 −22.504 1.00 19.96 B C ATOM 14433 CB LEU B 381 44.226 18.505 −22.047 1.00 18.35 B C ATOM 14436 CG LEU B 381 45.196 18.161 −23.167 1.00 22.53 B C ATOM 14438 CD1 LEU B 381 45.503 19.376 −24.030 1.00 16.10 B C ATOM 14442 CD2 LEU B 381 46.453 17.579 −22.589 1.00 16.33 B C ATOM 14446 C LEU B 381 42.197 18.127 −23.456 1.00 19.12 B C ATOM 14447 O LEU B 381 42.162 18.365 −24.641 1.00 19.21 B O ATOM 14449 N CYS B 382 41.610 17.060 −22.943 1.00 20.99 B N ATOM 14450 CA CYS B 382 40.929 16.115 −23.842 1.00 19.91 B C ATOM 14452 CB CYS B 382 40.480 14.866 −23.077 1.00 19.91 B C ATOM 14455 SG CYS B 382 41.915 13.875 −22.517 1.00 24.88 B S ATOM 14457 C CYS B 382 39.775 16.780 −24.594 1.00 19.49 B C ATOM 14458 O CYS B 382 39.598 16.514 −25.774 1.00 22.41 B O ATOM 14460 N ASN B 383 39.013 17.660 −23.938 1.00 19.54 B N ATOM 14461 CA ASN B 383 37.953 18.433 −24.628 1.00 19.38 B C ATOM 14463 CB ASN B 383 37.078 19.250 −23.644 1.00 17.80 B C ATOM 14466 CG ASN B 383 35.976 18.410 −23.013 1.00 21.83 B C ATOM 14467 OD1 ASN B 383 35.030 18.011 −23.692 1.00 28.68 B O ATOM 14468 ND2 ASN B 383 36.105 18.115 −21.715 1.00 19.68 B N ATOM 14471 C ASN B 383 38.514 19.360 −25.704 1.00 20.03 B C ATOM 14472 O ASN B 383 37.876 19.576 −26.722 1.00 21.15 B O ATOM 14474 N ALA B 384 39.708 19.905 −25.491 1.00 19.68 B N ATOM 14475 CA ALA B 384 40.312 20.759 −26.500 1.00 18.25 B C ATOM 14477 CB ALA B 384 41.412 21.600 −25.902 1.00 16.95 B C ATOM 14481 C ALA B 384 40.799 19.897 −27.676 1.00 19.74 B C ATOM 14482 O ALA B 384 40.642 20.274 −28.845 1.00 20.58 B O ATOM 14484 N PHE B 385 41.308 18.706 −27.396 1.00 19.10 B N ATOM 14485 CA PHE B 385 41.644 17.783 −28.492 1.00 19.23 B C ATOM 14487 CB PHE B 385 42.336 16.521 −27.964 1.00 19.77 B C ATOM 14490 CG PHE B 385 43.757 16.714 −27.473 1.00 20.37 B C ATOM 14491 CD1 PHE B 385 44.639 17.573 −28.099 1.00 29.85 B C ATOM 14493 CE1 PHE B 385 45.940 17.681 −27.665 1.00 22.48 B C ATOM 14495 CZ PHE B 385 46.382 16.924 −26.617 1.00 24.37 B C ATOM 14497 CE2 PHE B 385 45.540 16.037 −26.022 1.00 19.74 B C ATOM 14499 CD2 PHE B 385 44.238 15.934 −26.441 1.00 22.30 B C ATOM 14501 C PHE B 385 40.375 17.371 −29.231 1.00 19.10 B C ATOM 14502 O PHE B 385 40.352 17.236 −30.447 1.00 20.62 B O ATOM 14504 N LEU B 386 39.293 17.190 −28.487 1.00 20.82 B N ATOM 14505 CA LEU B 386 38.062 16.710 −29.088 1.00 19.64 B C ATOM 14507 CB LEU B 386 37.033 16.356 −28.010 1.00 17.81 B C ATOM 14510 CG LEU B 386 35.711 15.780 −28.547 1.00 24.89 B C ATOM 14512 CD1 LEU B 386 35.866 14.382 −29.197 1.00 17.85 B C ATOM 14516 CD2 LEU B 386 34.649 15.792 −27.450 1.00 13.88 B C ATOM 14520 C LEU B 386 37.531 17.758 −30.044 1.00 19.89 B C ATOM 14521 O LEU B 386 37.114 17.439 −31.142 1.00 22.28 B O ATOM 14523 N GLN B 387 37.561 19.018 −29.629 1.00 22.06 B N ATOM 14524 CA GLN B 387 37.101 20.123 −30.479 1.00 21.92 B C ATOM 14526 CB GLN B 387 37.163 21.490 −29.736 1.00 23.65 B C ATOM 14529 CG GLN B 387 36.756 22.718 −30.578 1.00 24.14 B C ATOM 14532 CD GLN B 387 35.325 22.625 −31.073 1.00 16.59 B C ATOM 14533 OE1 GLN B 387 35.071 22.082 −32.132 1.00 26.49 B O ATOM 14534 NE2 GLN B 387 34.397 23.060 −30.270 1.00 21.29 B N ATOM 14537 C GLN B 387 37.902 20.163 −31.769 1.00 20.75 B C ATOM 14538 O GLN B 387 37.326 20.380 −32.815 1.00 21.62 B O ATOM 14540 N GLU B 388 39.211 19.914 −31.714 1.00 21.58 B N ATOM 14541 CA GLU B 388 40.045 19.919 −32.920 1.00 22.44 B C ATOM 14543 CB GLU B 388 41.538 19.854 −32.588 1.00 25.28 B C ATOM 14546 CG GLU B 388 42.068 21.146 −31.939 1.00 32.65 B C ATOM 14549 CD GLU B 388 43.555 21.107 −31.568 1.00 35.29 B C ATOM 14550 OE1 GLU B 388 44.121 20.004 −31.343 1.00 36.54 B O ATOM 14551 OE2 GLU B 388 44.158 22.197 −31.498 1.00 33.60 B O ATOM 14552 C GLU B 388 39.688 18.754 −33.825 1.00 21.97 B C ATOM 14553 O GLU B 388 39.651 18.903 −35.039 1.00 21.50 B O ATOM 14555 N ALA B 389 39.381 17.607 −33.236 1.00 21.26 B N ATOM 14556 CA ALA B 389 39.026 16.445 −34.048 1.00 21.14 B C ATOM 14558 CB ALA B 389 38.959 15.156 −33.221 1.00 20.09 B C ATOM 14562 C ALA B 389 37.707 16.691 −34.731 1.00 19.85 B C ATOM 14563 O ALA B 389 37.538 16.311 −35.875 1.00 20.01 B O ATOM 14565 N LYS B 390 36.771 17.324 −34.040 1.00 19.84 B N ATOM 14566 CA LYS B 390 35.453 17.575 −34.629 1.00 22.05 B C ATOM 14568 CB LYS B 390 34.455 18.051 −33.572 1.00 24.20 B C ATOM 14571 CG LYS B 390 33.969 17.003 −32.647 1.00 22.59 B C ATOM 14574 CD LYS B 390 32.947 17.600 −31.704 1.00 34.38 B C ATOM 14577 CE LYS B 390 32.409 16.563 −30.729 1.00 32.22 B C ATOM 14580 NZ LYS B 390 31.908 17.280 −29.517 1.00 30.01 B N ATOM 14584 C LYS B 390 35.491 18.607 −35.745 1.00 21.67 B C ATOM 14585 O LYS B 390 34.748 18.501 −36.709 1.00 21.81 B O ATOM 14587 N TRP B 391 36.349 19.609 −35.593 1.00 22.17 B N ATOM 14588 CA TRP B 391 36.538 20.662 −36.605 1.00 22.08 B C ATOM 14590 CB TRP B 391 37.462 21.803 −36.091 1.00 20.61 B C ATOM 14593 CG TRP B 391 36.758 22.833 −35.264 1.00 21.47 B C ATOM 14594 CD1 TRP B 391 35.444 23.170 −35.325 1.00 21.71 B C ATOM 14596 NE1 TRP B 391 35.169 24.177 −34.438 1.00 25.90 B N ATOM 14598 CE2 TRP B 391 36.322 24.519 −33.791 1.00 19.12 B C ATOM 14599 CD2 TRP B 391 37.345 23.702 −34.295 1.00 20.50 B C ATOM 14600 CE3 TRP B 391 38.639 23.845 −33.778 1.00 23.66 B C ATOM 14602 CZ3 TRP B 391 38.860 24.792 −32.811 1.00 18.30 B C ATOM 14604 CH2 TRP B 391 37.825 25.605 −32.338 1.00 18.94 B C ATOM 14606 CZ2 TRP B 391 36.546 25.480 −32.804 1.00 20.38 B C ATOM 14608 C TRP B 391 37.132 20.090 −37.860 1.00 22.57 B C ATOM 14609 O TRP B 391 36.765 20.495 −38.976 1.00 18.85 B O ATOM 14611 N LEU B 392 38.089 19.189 −37.676 1.00 23.55 B N ATOM 14612 CA LEU B 392 38.703 18.505 −38.812 1.00 27.40 B C ATOM 14614 CB LEU B 392 39.929 17.704 −38.359 1.00 28.77 B C ATOM 14617 CG LEU B 392 40.742 17.113 −39.517 1.00 37.78 B C ATOM 14619 CD1 LEU B 392 41.420 18.237 −40.349 1.00 40.60 B C ATOM 14623 CD2 LEU B 392 41.775 16.124 −38.979 1.00 38.73 B C ATOM 14627 C LEU B 392 37.674 17.591 −39.509 1.00 25.45 B C ATOM 14628 O LEU B 392 37.457 17.687 −40.714 1.00 24.87 B O ATOM 14630 N TYR B 393 36.998 16.748 −38.744 1.00 24.92 B N ATOM 14631 CA TYR B 393 35.977 15.878 −39.329 1.00 27.07 B C ATOM 14633 CB TYR B 393 35.261 15.065 −38.248 1.00 27.20 B C ATOM 14636 CG TYR B 393 34.250 14.084 −38.801 1.00 32.35 B C ATOM 14637 CD1 TYR B 393 34.635 12.817 −39.240 1.00 36.10 B C ATOM 14639 CE1 TYR B 393 33.685 11.915 −39.762 1.00 41.26 B C ATOM 14641 CZ TYR B 393 32.347 12.292 −39.829 1.00 42.05 B C ATOM 14642 OH TYR B 393 31.387 11.441 −40.331 1.00 49.85 B O ATOM 14644 CE2 TYR B 393 31.959 13.542 −39.397 1.00 40.87 B C ATOM 14646 CD2 TYR B 393 32.906 14.426 −38.890 1.00 37.12 B C ATOM 14648 C TYR B 393 34.940 16.684 −40.109 1.00 26.51 B C ATOM 14649 O TYR B 393 34.686 16.403 −41.270 1.00 26.33 B O ATOM 14651 N ASN B 394 34.341 17.685 −39.460 1.00 26.40 B N ATOM 14652 CA ASN B 394 33.277 18.486 −40.081 1.00 27.32 B C ATOM 14654 CB ASN B 394 32.442 19.175 −38.993 1.00 28.58 B C ATOM 14657 CG ASN B 394 31.679 18.176 −38.123 1.00 28.94 B C ATOM 14658 OD1 ASN B 394 31.111 17.223 −38.628 1.00 34.61 B O ATOM 14659 ND2 ASN B 394 31.632 18.420 −36.833 1.00 30.26 B N ATOM 14662 C ASN B 394 33.781 19.513 −41.110 1.00 27.48 B C ATOM 14663 O ASN B 394 32.997 20.225 −41.670 1.00 27.41 B O ATOM 14665 N LYS B 395 35.089 19.562 −41.372 1.00 29.77 B N ATOM 14666 CA LYS B 395 35.702 20.601 −42.222 1.00 31.41 B C ATOM 14668 CB LYS B 395 35.413 20.316 −43.699 1.00 33.28 B C ATOM 14671 CG LYS B 395 36.114 19.035 −44.217 1.00 41.09 B C ATOM 14674 CD LYS B 395 35.295 18.354 −45.321 1.00 50.28 B C ATOM 14677 CE LYS B 395 36.139 17.389 −46.164 1.00 54.00 B C ATOM 14680 NZ LYS B 395 36.929 16.446 −45.322 1.00 54.63 B N ATOM 14684 C LYS B 395 35.303 22.041 −41.811 1.00 31.59 B C ATOM 14685 O LYS B 395 35.164 22.939 −42.649 1.00 32.31 B O ATOM 14687 N SER B 396 35.137 22.249 −40.504 1.00 30.78 B N ATOM 14688 CA SER B 396 34.832 23.558 −39.971 1.00 29.21 B C ATOM 14690 CB SER B 396 34.656 23.475 −38.479 1.00 29.18 B C ATOM 14693 OG SER B 396 33.613 22.573 −38.184 1.00 28.88 B O ATOM 14695 C SER B 396 35.962 24.492 −40.327 1.00 28.15 B C ATOM 14696 O SER B 396 37.054 24.038 −40.604 1.00 30.53 B O ATOM 14698 N THR B 397 35.666 25.788 −40.360 1.00 26.95 B N ATOM 14699 CA THR B 397 36.617 26.847 −40.705 1.00 25.06 B C ATOM 14701 CB THR B 397 36.309 27.435 −42.117 1.00 27.07 B C ATOM 14703 OG1 THR B 397 34.924 27.817 −42.180 1.00 25.75 B O ATOM 14705 CG2 THR B 397 36.576 26.369 −43.218 1.00 27.27 B C ATOM 14709 C THR B 397 36.509 27.959 −39.641 1.00 24.96 B C ATOM 14710 O THR B 397 36.177 29.100 −39.937 1.00 24.56 B O ATOM 14712 N PRO B 398 36.791 27.622 −38.388 1.00 21.45 B N ATOM 14713 CA PRO B 398 36.633 28.604 −37.323 1.00 22.11 B C ATOM 14715 CB PRO B 398 37.058 27.831 −36.068 1.00 22.56 B C ATOM 14718 CG PRO B 398 37.975 26.737 −36.622 1.00 23.07 B C ATOM 14721 CD PRO B 398 37.438 26.379 −37.933 1.00 20.76 B C ATOM 14724 C PRO B 398 37.525 29.813 −37.478 1.00 19.82 B C ATOM 14725 O PRO B 398 38.602 29.720 −38.032 1.00 22.01 B O ATOM 14726 N THR B 399 37.093 30.930 −36.920 1.00 17.51 B N ATOM 14727 CA THR B 399 37.889 32.130 −36.915 1.00 15.86 B C ATOM 14729 CB THR B 399 37.165 33.304 −36.225 1.00 17.11 B C ATOM 14731 OG1 THR B 399 37.060 32.998 −34.850 1.00 14.13 B O ATOM 14733 CG2 THR B 399 35.717 33.586 −36.827 1.00 8.38 B C ATOM 14737 C THR B 399 39.152 31.912 −36.130 1.00 16.82 B C ATOM 14738 O THR B 399 39.258 30.995 −35.292 1.00 16.62 B O ATOM 14740 N PHE B 400 40.099 32.806 −36.356 1.00 17.90 B N ATOM 14741 CA PHE B 400 41.335 32.771 −35.628 1.00 20.04 B C ATOM 14743 CB PHE B 400 42.240 33.952 −35.999 1.00 19.33 B C ATOM 14746 CG PHE B 400 43.454 34.023 −35.144 1.00 22.23 B C ATOM 14747 CD1 PHE B 400 44.521 33.161 −35.374 1.00 25.77 B C ATOM 14749 CE1 PHE B 400 45.663 33.194 −34.559 1.00 23.21 B C ATOM 14751 CZ PHE B 400 45.721 34.093 −33.485 1.00 22.27 B C ATOM 14753 CE2 PHE B 400 44.655 34.955 −33.244 1.00 24.82 B C ATOM 14755 CD2 PHE B 400 43.524 34.914 −34.075 1.00 25.67 B C ATOM 14757 C PHE B 400 41.113 32.770 −34.120 1.00 20.59 B C ATOM 14758 O PHE B 400 41.692 31.965 −33.427 1.00 19.12 B O ATOM 14760 N ASP B 401 40.339 33.726 −33.612 1.00 19.68 B N ATOM 14761 CA ASP B 401 40.065 33.780 −32.186 1.00 20.55 B C ATOM 14763 CB ASP B 401 39.100 34.942 −31.855 1.00 19.50 B C ATOM 14766 CG ASP B 401 39.771 36.314 −31.977 1.00 26.06 B C ATOM 14767 OD1 ASP B 401 41.024 36.425 −31.871 1.00 27.25 B O ATOM 14768 OD2 ASP B 401 39.040 37.283 −32.190 1.00 31.85 B O ATOM 14769 C ASP B 401 39.518 32.467 −31.609 1.00 19.11 B C ATOM 14770 O ASP B 401 39.910 32.084 −30.525 1.00 15.67 B O ATOM 14772 N ASP B 402 38.582 31.816 −32.294 1.00 18.01 B N ATOM 14773 CA ASP B 402 38.058 30.539 −31.800 1.00 20.72 B C ATOM 14775 CB ASP B 402 36.784 30.151 −32.556 1.00 21.12 B C ATOM 14778 CG ASP B 402 35.608 31.018 −32.192 1.00 24.45 B C ATOM 14779 OD1 ASP B 402 35.626 31.614 −31.100 1.00 34.43 B O ATOM 14780 OD2 ASP B 402 34.655 31.099 −32.986 1.00 33.91 B O ATOM 14781 C ASP B 402 39.102 29.413 −31.902 1.00 20.64 B C ATOM 14782 O ASP B 402 39.301 28.658 −30.946 1.00 20.80 B O ATOM 14784 N TYR B 403 39.796 29.322 −33.037 1.00 17.89 B N ATOM 14785 CA TYR B 403 40.782 28.278 −33.195 1.00 20.95 B C ATOM 14787 CB TYR B 403 41.398 28.285 −34.593 1.00 24.16 B C ATOM 14790 CG TYR B 403 42.415 27.191 −34.774 1.00 25.07 B C ATOM 14791 CD1 TYR B 403 41.994 25.920 −35.085 1.00 33.87 B C ATOM 14793 CE1 TYR B 403 42.869 24.897 −35.245 1.00 36.88 B C ATOM 14795 CZ TYR B 403 44.210 25.112 −35.091 1.00 36.98 B C ATOM 14796 OH TYR B 403 45.014 24.010 −35.296 1.00 43.37 B O ATOM 14798 CE2 TYR B 403 44.688 26.381 −34.763 1.00 35.63 B C ATOM 14800 CD2 TYR B 403 43.772 27.416 −34.602 1.00 28.89 B C ATOM 14802 C TYR B 403 41.897 28.421 −32.195 1.00 20.62 B C ATOM 14803 O TYR B 403 42.306 27.462 −31.567 1.00 21.48 B O ATOM 14805 N PHE B 404 42.401 29.633 −32.053 1.00 21.49 B N ATOM 14806 CA PHE B 404 43.555 29.869 −31.181 1.00 21.36 B C ATOM 14808 CB PHE B 404 44.194 31.232 −31.479 1.00 20.72 B C ATOM 14811 CG PHE B 404 45.349 31.561 −30.618 1.00 18.53 B C ATOM 14812 CD1 PHE B 404 46.497 30.774 −30.637 1.00 24.02 B C ATOM 14814 CE1 PHE B 404 47.570 31.076 −29.822 1.00 19.40 B C ATOM 14816 CZ PHE B 404 47.510 32.189 −28.985 1.00 21.28 B C ATOM 14818 CE2 PHE B 404 46.382 32.969 −28.957 1.00 24.12 B C ATOM 14820 CD2 PHE B 404 45.306 32.658 −29.776 1.00 23.06 B C ATOM 14822 C PHE B 404 43.125 29.726 −29.740 1.00 21.63 B C ATOM 14823 O PHE B 404 43.825 29.110 −28.945 1.00 17.99 B O ATOM 14825 N GLY B 405 41.946 30.249 −29.399 1.00 22.47 B N ATOM 14826 CA GLY B 405 41.436 30.071 −28.039 1.00 22.00 B C ATOM 14829 C GLY B 405 41.509 28.604 −27.605 1.00 23.01 B C ATOM 14830 O GLY B 405 41.945 28.286 −26.503 1.00 25.26 B O ATOM 14832 N ASN B 406 41.049 27.711 −28.474 1.00 21.92 B N ATOM 14833 CA ASN B 406 41.158 26.281 −28.253 1.00 21.40 B C ATOM 14835 CB ASN B 406 40.293 25.515 −29.253 1.00 21.75 B C ATOM 14838 CG ASN B 406 40.155 24.061 −28.891 1.00 24.28 B C ATOM 14839 OD1 ASN B 406 39.504 23.735 −27.911 1.00 22.62 B O ATOM 14840 ND2 ASN B 406 40.776 23.176 −29.681 1.00 16.03 B N ATOM 14843 C ASN B 406 42.606 25.765 −28.361 1.00 20.04 B C ATOM 14844 O ASN B 406 43.029 24.937 −27.563 1.00 20.34 B O ATOM 14846 N ALA B 407 43.348 26.236 −29.353 1.00 18.11 B N ATOM 14847 CA ALA B 407 44.675 25.668 −29.610 1.00 19.56 B C ATOM 14849 CB ALA B 407 45.224 26.153 −30.939 1.00 16.25 B C ATOM 14853 C ALA B 407 45.701 25.884 −28.493 1.00 20.02 B C ATOM 14854 O ALA B 407 46.604 25.031 −28.294 1.00 20.33 B O ATOM 14856 N TRP B 408 45.611 27.007 −27.782 1.00 18.45 B N ATOM 14857 CA TRP B 408 46.564 27.232 −26.710 1.00 20.53 B C ATOM 14859 CB TRP B 408 46.737 28.706 −26.290 1.00 19.32 B C ATOM 14862 CG TRP B 408 45.544 29.473 −25.694 1.00 19.23 B C ATOM 14863 CD1 TRP B 408 44.789 30.419 −26.330 1.00 22.29 B C ATOM 14865 NE1 TRP B 408 43.833 30.934 −25.473 1.00 20.57 B N ATOM 14867 CE2 TRP B 408 43.966 30.336 −24.257 1.00 21.54 B C ATOM 14868 CD2 TRP B 408 45.052 29.418 −24.351 1.00 22.09 B C ATOM 14869 CE3 TRP B 408 45.409 28.682 −23.214 1.00 22.59 B C ATOM 14871 CZ3 TRP B 408 44.687 28.893 −22.028 1.00 23.88 B C ATOM 14873 CH2 TRP B 408 43.606 29.809 −21.980 1.00 21.62 B C ATOM 14875 CZ2 TRP B 408 43.244 30.540 −23.076 1.00 24.64 B C ATOM 14877 C TRP B 408 46.269 26.329 −25.543 1.00 20.19 B C ATOM 14878 O TRP B 408 47.159 26.031 −24.773 1.00 24.69 B O ATOM 14880 N LYS B 409 45.040 25.858 −25.431 1.00 19.87 B N ATOM 14881 CA LYS B 409 44.720 24.842 −24.443 1.00 20.66 B C ATOM 14883 CB LYS B 409 43.222 24.797 −24.163 1.00 18.56 B C ATOM 14886 CG LYS B 409 42.667 26.085 −23.503 1.00 25.88 B C ATOM 14889 CD LYS B 409 41.159 26.021 −23.179 1.00 33.24 B C ATOM 14892 CE LYS B 409 40.581 27.370 −22.701 1.00 37.85 B C ATOM 14895 NZ LYS B 409 40.211 28.350 −23.840 1.00 45.13 B N ATOM 14899 C LYS B 409 45.248 23.476 −24.902 1.00 20.55 B C ATOM 14900 O LYS B 409 45.859 22.746 −24.116 1.00 18.30 B O ATOM 14902 N SER B 410 45.068 23.178 −26.186 1.00 20.61 B N ATOM 14903 CA SER B 410 45.448 21.878 −26.756 1.00 20.11 B C ATOM 14905 CB SER B 410 44.882 21.701 −28.183 1.00 21.28 B C ATOM 14908 OG SER B 410 45.676 22.371 −29.177 1.00 18.53 B O ATOM 14910 C SER B 410 46.943 21.693 −26.827 1.00 21.39 B C ATOM 14911 O SER B 410 47.400 20.598 −27.087 1.00 21.38 B O ATOM 14913 N SER B 411 47.703 22.775 −26.667 1.00 22.35 B N ATOM 14914 CA SER B 411 49.155 22.694 −26.608 1.00 20.21 B C ATOM 14916 CB SER B 411 49.790 24.084 −26.486 1.00 21.74 B C ATOM 14919 OG SER B 411 49.520 24.719 −25.216 1.00 20.26 B O ATOM 14921 C SER B 411 49.584 21.872 −25.411 1.00 19.55 B C ATOM 14922 O SER B 411 50.645 21.322 −25.433 1.00 19.31 B O ATOM 14924 N SER B 412 48.738 21.814 −24.380 1.00 21.60 B N ATOM 14925 CA SER B 412 49.017 21.190 −23.068 1.00 22.15 B C ATOM 14927 CB SER B 412 49.701 19.819 −23.183 1.00 22.20 B C ATOM 14930 OG SER B 412 51.094 19.930 −23.403 1.00 20.47 B O ATOM 14932 C SER B 412 49.810 22.101 −22.119 1.00 21.31 B C ATOM 14933 O SER B 412 50.103 21.730 −20.970 1.00 21.57 B O ATOM 14935 N GLY B 413 50.107 23.308 −22.574 1.00 18.89 B N ATOM 14936 CA GLY B 413 50.807 24.295 −21.751 1.00 19.18 B C ATOM 14939 C GLY B 413 50.152 24.531 −20.408 1.00 19.27 B C ATOM 14940 O GLY B 413 50.809 24.440 −19.363 1.00 20.22 B O ATOM 14942 N PRO B 414 48.851 24.815 −20.412 1.00 17.74 B N ATOM 14943 CA PRO B 414 48.178 25.038 −19.143 1.00 20.20 B C ATOM 14945 CB PRO B 414 46.720 25.297 −19.567 1.00 20.76 B C ATOM 14948 CG PRO B 414 46.881 25.963 −20.871 1.00 16.96 B C ATOM 14951 CD PRO B 414 47.965 25.139 −21.537 1.00 18.57 B C ATOM 14954 C PRO B 414 48.247 23.840 −18.218 1.00 20.58 B C ATOM 14955 O PRO B 414 48.536 23.995 −17.047 1.00 20.97 B O ATOM 14956 N LEU B 415 48.005 22.654 −18.768 1.00 22.11 B N ATOM 14957 CA LEU B 415 48.040 21.432 −17.994 1.00 21.93 B C ATOM 14959 CB LEU B 415 47.677 20.224 −18.870 1.00 22.71 B C ATOM 14962 CG LEU B 415 47.827 18.842 −18.222 1.00 24.25 B C ATOM 14964 CD1 LEU B 415 46.773 17.860 −18.751 1.00 21.18 B C ATOM 14968 CD2 LEU B 415 49.234 18.290 −18.421 1.00 23.53 B C ATOM 14972 C LEU B 415 49.420 21.225 −17.393 1.00 22.23 B C ATOM 14973 O LEU B 415 49.540 20.955 −16.209 1.00 21.62 B O ATOM 14975 N GLN B 416 50.459 21.330 −18.214 1.00 21.75 B N ATOM 14976 CA GLN B 416 51.824 21.221 −17.701 1.00 20.58 B C ATOM 14978 CB GLN B 416 52.834 21.502 −18.790 1.00 19.97 B C ATOM 14981 CG GLN B 416 52.840 20.447 −19.842 1.00 19.48 B C ATOM 14984 CD GLN B 416 53.920 20.659 −20.837 1.00 26.66 B C ATOM 14985 OE1 GLN B 416 55.002 21.132 −20.494 1.00 29.08 B O ATOM 14986 NE2 GLN B 416 53.658 20.284 −22.089 1.00 24.07 B N ATOM 14989 C GLN B 416 52.062 22.162 −16.544 1.00 21.03 B C ATOM 14990 O GLN B 416 52.701 21.799 −15.558 1.00 23.28 B O ATOM 14992 N LEU B 417 51.545 23.374 −16.636 1.00 19.90 B N ATOM 14993 CA LEU B 417 51.878 24.340 −15.611 1.00 20.19 B C ATOM 14995 CB LEU B 417 51.770 25.766 −16.117 1.00 20.53 B C ATOM 14998 CG LEU B 417 52.799 26.171 −17.174 1.00 17.82 B C ATOM 15000 CD1 LEU B 417 52.466 27.556 −17.758 1.00 18.27 B C ATOM 15004 CD2 LEU B 417 54.219 26.142 −16.607 1.00 18.14 B C ATOM 15008 C LEU B 417 51.034 24.114 −14.371 1.00 20.73 B C ATOM 15009 O LEU B 417 51.472 24.460 −13.291 1.00 21.82 B O ATOM 15011 N VAL B 418 49.841 23.516 −14.500 1.00 21.29 B N ATOM 15012 CA VAL B 418 49.081 23.104 −13.310 1.00 20.26 B C ATOM 15014 CB VAL B 418 47.702 22.530 −13.655 1.00 21.33 B C ATOM 15016 CG1 VAL B 418 46.715 23.671 −14.083 1.00 17.04 B C ATOM 15020 CG2 VAL B 418 47.139 21.793 −12.468 1.00 19.19 B C ATOM 15024 C VAL B 418 49.929 22.077 −12.549 1.00 21.33 B C ATOM 15025 O VAL B 418 50.114 22.181 −11.350 1.00 21.65 B O ATOM 15027 N PHE B 419 50.498 21.125 −13.269 1.00 18.97 B N ATOM 15028 CA PHE B 419 51.345 20.140 −12.648 1.00 19.89 B C ATOM 15030 CB PHE B 419 51.657 19.015 −13.610 1.00 19.38 B C ATOM 15033 CG PHE B 419 50.563 17.967 −13.689 1.00 19.90 B C ATOM 15034 CD1 PHE B 419 50.670 16.777 −12.971 1.00 18.98 B C ATOM 15036 CE1 PHE B 419 49.668 15.827 −13.011 1.00 19.09 B C ATOM 15038 CZ PHE B 419 48.533 16.046 −13.802 1.00 20.18 B C ATOM 15040 CE2 PHE B 419 48.424 17.216 −14.534 1.00 18.86 B C ATOM 15042 CD2 PHE B 419 49.436 18.178 −14.460 1.00 17.01 B C ATOM 15044 C PHE B 419 52.620 20.762 −12.087 1.00 20.16 B C ATOM 15045 O PHE B 419 53.021 20.417 −10.991 1.00 20.38 B O ATOM 15047 N ALA B 420 53.239 21.684 −12.812 1.00 20.42 B N ATOM 15048 CA ALA B 420 54.427 22.338 −12.289 1.00 23.24 B C ATOM 15050 CB ALA B 420 55.062 23.322 −13.324 1.00 21.28 B C ATOM 15054 C ALA B 420 54.061 23.045 −10.988 1.00 24.47 B C ATOM 15055 O ALA B 420 54.800 22.943 −10.007 1.00 25.28 B O ATOM 15057 N TYR B 421 52.889 23.683 −10.947 1.00 24.54 B N ATOM 15058 CA TYR B 421 52.478 24.429 −9.753 1.00 23.69 B C ATOM 15060 CB TYR B 421 51.039 24.958 −9.879 1.00 23.32 B C ATOM 15063 CG TYR B 421 50.497 25.608 −8.616 1.00 24.00 B C ATOM 15064 CD1 TYR B 421 50.904 26.885 −8.220 1.00 27.39 B C ATOM 15066 CE1 TYR B 421 50.418 27.466 −7.053 1.00 26.70 B C ATOM 15068 CZ TYR B 421 49.527 26.759 −6.268 1.00 27.74 B C ATOM 15069 OH TYR B 421 49.003 27.300 −5.109 1.00 29.86 B O ATOM 15071 CE2 TYR B 421 49.129 25.503 −6.642 1.00 26.17 B C ATOM 15073 CD2 TYR B 421 49.616 24.931 −7.797 1.00 28.12 B C ATOM 15075 C TYR B 421 52.618 23.546 −8.524 1.00 25.70 B C ATOM 15076 O TYR B 421 53.296 23.894 −7.553 1.00 25.07 B O ATOM 15078 N PHE B 422 52.001 22.374 −8.560 1.00 26.45 B N ATOM 15079 CA PHE B 422 51.998 21.538 −7.363 1.00 23.99 B C ATOM 15081 CB PHE B 422 50.959 20.448 −7.476 1.00 23.45 B C ATOM 15084 CG PHE B 422 49.564 20.962 −7.545 1.00 21.76 B C ATOM 15085 CD1 PHE B 422 48.963 21.499 −6.425 1.00 22.67 B C ATOM 15087 CE1 PHE B 422 47.677 21.970 −6.487 1.00 22.09 B C ATOM 15089 CZ PHE B 422 46.996 21.931 −7.682 1.00 23.94 B C ATOM 15091 CE2 PHE B 422 47.594 21.400 −8.798 1.00 24.20 B C ATOM 15093 CD2 PHE B 422 48.852 20.905 −8.722 1.00 21.31 B C ATOM 15095 C PHE B 422 53.386 20.973 −7.060 1.00 25.00 B C ATOM 15096 O PHE B 422 53.687 20.659 −5.916 1.00 27.56 B O ATOM 15098 N ALA B 423 54.245 20.878 −8.067 1.00 24.59 B N ATOM 15099 CA ALA B 423 55.591 20.352 −7.857 1.00 24.37 B C ATOM 15101 CB ALA B 423 56.065 19.705 −9.117 1.00 21.00 B C ATOM 15105 C ALA B 423 56.647 21.370 −7.363 1.00 26.64 B C ATOM 15106 O ALA B 423 57.710 20.965 −6.870 1.00 30.03 B O ATOM 15108 N VAL B 424 56.397 22.664 −7.547 1.00 27.57 B N ATOM 15109 CA VAL B 424 57.351 23.700 −7.160 1.00 29.54 B C ATOM 15111 CB VAL B 424 57.704 24.619 −8.341 1.00 29.56 B C ATOM 15113 CG1 VAL B 424 58.149 23.780 −9.552 1.00 26.25 B C ATOM 15117 CG2 VAL B 424 56.527 25.557 −8.684 1.00 22.59 B C ATOM 15121 C VAL B 424 56.887 24.597 −6.011 1.00 32.82 B C ATOM 15122 O VAL B 424 57.704 25.262 −5.422 1.00 34.23 B O ATOM 15124 N VAL B 425 55.593 24.633 −5.713 1.00 34.79 B N ATOM 15125 CA VAL B 425 55.076 25.505 −4.675 1.00 38.89 B C ATOM 15127 CB VAL B 425 53.717 26.073 −5.071 1.00 39.09 B C ATOM 15129 CG1 VAL B 425 53.005 26.649 −3.867 1.00 38.93 B C ATOM 15133 CG2 VAL B 425 53.911 27.138 −6.142 1.00 37.94 B C ATOM 15137 C VAL B 425 54.946 24.779 −3.343 1.00 43.65 B C ATOM 15138 O VAL B 425 54.204 23.803 −3.242 1.00 45.04 B O ATOM 15140 N GLN B 426 55.647 25.279 −2.322 1.00 47.45 B N ATOM 15141 CA GLN B 426 55.676 24.630 −1.008 1.00 50.46 B C ATOM 15143 CB GLN B 426 56.627 25.368 −0.053 1.00 53.33 B C ATOM 15146 CG GLN B 426 58.129 25.084 −0.275 1.00 61.88 B C ATOM 15149 CD GLN B 426 59.034 25.792 0.746 1.00 68.89 B C ATOM 15150 OE1 GLN B 426 59.973 26.503 0.376 1.00 73.47 B O ATOM 15151 NE2 GLN B 426 58.742 25.602 2.034 1.00 69.40 B N ATOM 15154 C GLN B 426 54.285 24.519 −0.377 1.00 48.54 B C ATOM 15155 O GLN B 426 53.887 23.437 0.037 1.00 49.02 B O ATOM 15157 N ASN B 427 53.554 25.633 −0.316 1.00 46.21 B N ATOM 15158 CA ASN B 427 52.232 25.673 0.318 1.00 44.18 B C ATOM 15160 CB ASN B 427 52.271 26.578 1.552 1.00 45.10 B C ATOM 15163 CG ASN B 427 53.065 25.963 2.691 1.00 46.27 B C ATOM 15164 OD1 ASN B 427 52.520 25.213 3.510 1.00 43.08 B O ATOM 15165 ND2 ASN B 427 54.366 26.235 2.717 1.00 38.93 B N ATOM 15168 C ASN B 427 51.156 26.170 −0.631 1.00 42.56 B C ATOM 15169 O ASN B 427 51.127 27.352 −0.981 1.00 42.40 B O ATOM 15171 N ILE B 428 50.256 25.276 −1.024 1.00 40.21 B N ATOM 15172 CA ILE B 428 49.250 25.617 −2.008 1.00 40.37 B C ATOM 15174 CB ILE B 428 48.597 24.364 −2.634 1.00 41.28 B C ATOM 15176 CG1 ILE B 428 47.742 23.600 −1.630 1.00 40.63 B C ATOM 15179 CD1 ILE B 428 46.969 22.501 −2.264 1.00 38.48 B C ATOM 15183 CG2 ILE B 428 49.675 23.424 −3.196 1.00 43.55 B C ATOM 15187 C ILE B 428 48.200 26.516 −1.391 1.00 40.76 B C ATOM 15188 O ILE B 428 47.902 26.395 −0.201 1.00 41.46 B O ATOM 15190 N LYS B 429 47.657 27.422 −2.198 1.00 39.80 B N ATOM 15191 CA LYS B 429 46.602 28.323 −1.759 1.00 39.22 B C ATOM 15193 CB LYS B 429 47.071 29.776 −1.808 1.00 39.67 B C ATOM 15196 CG LYS B 429 48.269 30.048 −0.920 1.00 45.60 B C ATOM 15199 CD LYS B 429 48.879 31.429 −1.157 1.00 50.03 B C ATOM 15202 CE LYS B 429 50.249 31.534 −0.469 1.00 53.38 B C ATOM 15205 NZ LYS B 429 50.713 32.937 −0.367 1.00 55.16 B N ATOM 15209 C LYS B 429 45.389 28.158 −2.637 1.00 38.88 B C ATOM 15210 O LYS B 429 45.492 27.998 −3.854 1.00 37.10 B O ATOM 15212 N LYS B 430 44.229 28.230 −2.007 1.00 40.34 B N ATOM 15213 CA LYS B 430 42.985 27.967 −2.682 1.00 41.57 B C ATOM 15215 CB LYS B 430 41.820 28.099 −1.691 1.00 44.11 B C ATOM 15218 CG LYS B 430 40.448 27.690 −2.234 1.00 52.05 B C ATOM 15221 CD LYS B 430 39.363 27.760 −1.142 1.00 63.27 B C ATOM 15224 CE LYS B 430 38.943 29.200 −0.822 1.00 67.72 B C ATOM 15227 NZ LYS B 430 38.124 29.784 −1.928 1.00 71.21 B N ATOM 15231 C LYS B 430 42.802 28.927 −3.843 1.00 39.97 B C ATOM 15232 O LYS B 430 42.358 28.523 −4.913 1.00 39.98 B O ATOM 15234 N GLU B 431 43.130 30.198 −3.639 1.00 39.37 B N ATOM 15235 CA GLU B 431 42.843 31.191 −4.666 1.00 39.18 B C ATOM 15237 CB GLU B 431 42.743 32.612 −4.088 1.00 40.15 B C ATOM 15240 CG GLU B 431 44.049 33.364 −3.837 1.00 50.24 B C ATOM 15243 CD GLU B 431 43.829 34.872 −3.580 1.00 60.38 B C ATOM 15244 OE1 GLU B 431 43.114 35.532 −4.376 1.00 62.25 B O ATOM 15245 OE2 GLU B 431 44.376 35.396 −2.582 1.00 62.66 B O ATOM 15246 C GLU B 431 43.813 31.070 −5.848 1.00 35.93 B C ATOM 15247 O GLU B 431 43.442 31.367 −6.982 1.00 34.81 B O ATOM 15249 N GLU B 432 45.034 30.618 −5.585 1.00 33.41 B N ATOM 15250 CA GLU B 432 45.965 30.298 −6.660 1.00 33.72 B C ATOM 15252 CB GLU B 432 47.353 29.955 −6.109 1.00 33.21 B C ATOM 15255 CG GLU B 432 48.085 31.141 −5.456 1.00 32.22 B C ATOM 15258 CD GLU B 432 49.493 30.803 −4.956 1.00 37.75 B C ATOM 15259 OE1 GLU B 432 49.791 29.622 −4.631 1.00 34.91 B O ATOM 15260 OE2 GLU B 432 50.317 31.745 −4.883 1.00 45.57 B O ATOM 15261 C GLU B 432 45.406 29.146 −7.507 1.00 33.26 B C ATOM 15262 O GLU B 432 45.304 29.260 −8.728 1.00 34.10 B O ATOM 15264 N ILE B 433 44.992 28.056 −6.873 1.00 33.07 B N ATOM 15265 CA ILE B 433 44.509 26.923 −7.661 1.00 34.77 B C ATOM 15267 CB ILE B 433 44.529 25.571 −6.921 1.00 33.31 B C ATOM 15269 CG1 ILE B 433 43.828 25.602 −5.594 1.00 39.69 B C ATOM 15272 CD1 ILE B 433 44.565 24.744 −4.570 1.00 40.72 B C ATOM 15276 CG2 ILE B 433 45.949 25.194 −6.576 1.00 37.35 B C ATOM 15280 C ILE B 433 43.190 27.234 −8.334 1.00 33.17 B C ATOM 15281 O ILE B 433 42.938 26.745 −9.419 1.00 34.85 B O ATOM 15283 N GLU B 434 42.384 28.100 −7.750 1.00 31.81 B N ATOM 15284 CA GLU B 434 41.167 28.532 −8.428 1.00 33.28 B C ATOM 15286 CB GLU B 434 40.259 29.351 −7.499 1.00 36.58 B C ATOM 15289 CG GLU B 434 39.295 28.482 −6.669 1.00 45.80 B C ATOM 15292 CD GLU B 434 38.349 29.297 −5.797 1.00 58.22 B C ATOM 15293 OE1 GLU B 434 38.744 30.392 −5.318 1.00 61.60 B O ATOM 15294 OE2 GLU B 434 37.204 28.834 −5.597 1.00 62.57 B O ATOM 15295 C GLU B 434 41.470 29.333 −9.681 1.00 31.01 B C ATOM 15296 O GLU B 434 40.724 29.260 −10.669 1.00 32.01 B O ATOM 15298 N ASN B 435 42.546 30.108 −9.641 1.00 27.38 B N ATOM 15299 CA ASN B 435 42.931 30.894 −10.794 1.00 28.08 B C ATOM 15301 CB ASN B 435 43.789 32.084 −10.362 1.00 28.78 B C ATOM 15304 CG ASN B 435 42.934 33.315 −10.028 1.00 32.39 B C ATOM 15305 OD1 ASN B 435 42.351 33.953 −10.913 1.00 39.25 B O ATOM 15306 ND2 ASN B 435 42.835 33.621 −8.761 1.00 27.21 B N ATOM 15309 C ASN B 435 43.603 30.038 −11.878 1.00 27.27 B C ATOM 15310 O ASN B 435 43.453 30.315 −13.060 1.00 28.23 B O ATOM 15312 N LEU B 436 44.310 28.984 −11.483 1.00 27.03 B N ATOM 15313 CA LEU B 436 44.817 28.023 −12.463 1.00 28.24 B C ATOM 15315 CB LEU B 436 45.623 26.891 −11.820 1.00 27.45 B C ATOM 15318 CG LEU B 436 46.900 27.257 −11.062 1.00 26.99 B C ATOM 15320 CD1 LEU B 436 47.517 26.029 −10.392 1.00 25.59 B C ATOM 15324 CD2 LEU B 436 47.879 27.938 −11.979 1.00 26.36 B C ATOM 15328 C LEU B 436 43.639 27.442 −13.231 1.00 29.56 B C ATOM 15329 O LEU B 436 43.671 27.408 −14.445 1.00 30.09 B O ATOM 15331 N GLN B 437 42.577 27.034 −12.535 1.00 32.04 B N ATOM 15332 CA GLN B 437 41.444 26.395 −13.212 1.00 33.09 B C ATOM 15334 CB GLN B 437 40.418 25.838 −12.226 1.00 34.27 B C ATOM 15337 CG GLN B 437 40.927 24.764 −11.314 1.00 38.74 B C ATOM 15340 CD GLN B 437 39.827 23.808 −10.859 1.00 42.01 B C ATOM 15341 OE1 GLN B 437 39.776 22.664 −11.304 1.00 38.35 B O ATOM 15342 NE2 GLN B 437 38.949 24.275 −9.971 1.00 34.39 B N ATOM 15345 C GLN B 437 40.736 27.365 −14.137 1.00 32.68 B C ATOM 15346 O GLN B 437 40.030 26.933 −15.041 1.00 33.51 B O ATOM 15348 N LYS B 438 40.886 28.663 −13.893 1.00 31.93 B N ATOM 15349 CA LYS B 438 40.284 29.683 −14.765 1.00 34.40 B C ATOM 15351 CB LYS B 438 39.717 30.835 −13.933 1.00 36.15 B C ATOM 15354 CG LYS B 438 38.461 30.443 −13.155 1.00 46.92 B C ATOM 15357 CD LYS B 438 38.218 31.319 −11.915 1.00 56.20 B C ATOM 15360 CE LYS B 438 36.928 30.868 −11.170 1.00 62.26 B C ATOM 15363 NZ LYS B 438 36.666 31.585 −9.878 1.00 59.98 B N ATOM 15367 C LYS B 438 41.268 30.207 −15.810 1.00 31.95 B C ATOM 15368 O LYS B 438 40.973 31.152 −16.523 1.00 34.95 B O ATOM 15370 N TYR B 439 42.429 29.584 −15.901 1.00 30.59 B N ATOM 15371 CA TYR B 439 43.454 29.951 −16.874 1.00 31.05 B C ATOM 15373 CB TYR B 439 42.995 29.728 −18.308 1.00 31.76 B C ATOM 15376 CG TYR B 439 42.559 28.327 −18.592 1.00 35.31 B C ATOM 15377 CD1 TYR B 439 43.486 27.367 −18.911 1.00 31.89 B C ATOM 15379 CE1 TYR B 439 43.110 26.094 −19.190 1.00 44.43 B C ATOM 15381 CZ TYR B 439 41.785 25.748 −19.147 1.00 43.22 B C ATOM 15382 OH TYR B 439 41.462 24.467 −19.437 1.00 43.75 B O ATOM 15384 CE2 TYR B 439 40.808 26.685 −18.827 1.00 40.92 B C ATOM 15386 CD2 TYR B 439 41.202 27.970 −18.554 1.00 39.09 B C ATOM 15388 C TYR B 439 43.888 31.383 −16.714 1.00 29.52 B C ATOM 15389 O TYR B 439 43.889 32.157 −17.664 1.00 29.95 B O ATOM 15391 N HIS B 440 44.266 31.718 −15.493 1.00 29.00 B N ATOM 15392 CA HIS B 440 44.898 32.986 −15.198 1.00 27.83 B C ATOM 15394 CB HIS B 440 45.457 32.918 −13.782 1.00 27.70 B C ATOM 15397 CG HIS B 440 45.905 34.238 −13.250 1.00 34.45 B C ATOM 15398 ND1 HIS B 440 47.203 34.688 −13.373 1.00 33.50 B N ATOM 15400 CE1 HIS B 440 47.301 35.881 −12.815 1.00 35.67 B C ATOM 15402 NE2 HIS B 440 46.117 36.217 −12.336 1.00 38.29 B N ATOM 15404 CD2 HIS B 440 45.226 35.208 −12.599 1.00 32.67 B C ATOM 15406 C HIS B 440 46.052 33.277 −16.167 1.00 27.83 B C ATOM 15407 O HIS B 440 46.792 32.364 −16.577 1.00 23.95 B O ATOM 15409 N ASP B 441 46.206 34.557 −16.499 1.00 27.43 B N ATOM 15410 CA ASP B 441 47.296 35.072 −17.343 1.00 25.55 B C ATOM 15412 CB ASP B 441 47.448 36.575 −17.122 1.00 26.88 B C ATOM 15415 CG ASP B 441 46.214 37.382 −17.555 1.00 32.29 B C ATOM 15416 OD1 ASP B 441 45.520 36.981 −18.519 1.00 32.54 B O ATOM 15417 OD2 ASP B 441 45.947 38.424 −16.910 1.00 38.34 B O ATOM 15418 C ASP B 441 48.665 34.427 −17.077 1.00 25.73 B C ATOM 15419 O ASP B 441 49.455 34.247 −18.009 1.00 26.54 B O ATOM 15421 N THR B 442 48.956 34.084 −15.822 1.00 24.23 B N ATOM 15422 CA THR B 442 50.254 33.441 −15.475 1.00 25.82 B C ATOM 15424 CB THR B 442 50.317 33.025 −13.995 1.00 26.22 B C ATOM 15426 OG1 THR B 442 50.066 34.173 −13.192 1.00 32.69 B O ATOM 15428 CG2 THR B 442 51.692 32.497 −13.624 1.00 28.30 B C ATOM 15432 C THR B 442 50.562 32.211 −16.317 1.00 22.08 B C ATOM 15433 O THR B 442 51.699 31.994 −16.697 1.00 21.58 B O ATOM 15435 N ILE B 443 49.538 31.421 −16.605 1.00 22.63 B N ATOM 15436 CA ILE B 443 49.703 30.173 −17.329 1.00 21.27 B C ATOM 15438 CB ILE B 443 49.127 28.948 −16.523 1.00 21.12 B C ATOM 15440 CG1 ILE B 443 47.612 28.928 −16.433 1.00 22.72 B C ATOM 15443 CD1 ILE B 443 47.033 27.558 −15.846 1.00 18.38 B C ATOM 15447 CG2 ILE B 443 49.685 28.915 −15.113 1.00 22.19 B C ATOM 15451 C ILE B 443 49.151 30.266 −18.751 1.00 21.71 B C ATOM 15452 O ILE B 443 49.603 29.544 −19.632 1.00 22.40 B O ATOM 15454 N SER B 444 48.220 31.189 −19.008 1.00 23.19 B N ATOM 15455 CA SER B 444 47.657 31.292 −20.344 1.00 21.64 B C ATOM 15457 CB SER B 444 46.339 32.028 −20.345 1.00 21.22 B C ATOM 15460 OG SER B 444 46.478 33.360 −19.936 1.00 26.99 B O ATOM 15462 C SER B 444 48.652 31.930 −21.295 1.00 22.27 B C ATOM 15463 O SER B 444 48.885 31.427 −22.399 1.00 25.52 B O ATOM 15465 N ARG B 445 49.293 33.001 −20.867 1.00 21.71 B N ATOM 15466 CA ARG B 445 50.158 33.724 −21.788 1.00 21.57 B C ATOM 15468 CB ARG B 445 50.571 35.066 −21.210 1.00 22.03 B C ATOM 15471 CG ARG B 445 49.356 35.981 −21.031 1.00 23.51 B C ATOM 15474 CD ARG B 445 49.746 37.392 −20.947 1.00 35.75 B C ATOM 15477 NE ARG B 445 48.625 38.263 −20.586 1.00 46.32 B N ATOM 15479 CZ ARG B 445 48.524 38.956 −19.448 1.00 42.95 B C ATOM 15480 NH1 ARG B 445 49.463 38.885 −18.497 1.00 41.13 B N ATOM 15483 NH2 ARG B 445 47.463 39.730 −19.261 1.00 41.39 B N ATOM 15486 C ARG B 445 51.341 32.921 −22.275 1.00 22.15 B C ATOM 15487 O ARG B 445 51.581 32.896 −23.460 1.00 21.06 B O ATOM 15489 N PRO B 446 52.064 32.233 −21.371 1.00 20.64 B N ATOM 15490 CA PRO B 446 53.093 31.345 −21.884 1.00 20.55 B C ATOM 15492 CB PRO B 446 53.766 30.765 −20.628 1.00 21.36 B C ATOM 15495 CG PRO B 446 53.127 31.394 −19.456 1.00 26.98 B C ATOM 15498 CD PRO B 446 52.065 32.353 −19.908 1.00 22.16 B C ATOM 15501 C PRO B 446 52.529 30.224 −22.761 1.00 19.46 B C ATOM 15502 O PRO B 446 53.196 29.757 −23.671 1.00 19.46 B O ATOM 15503 N SER B 447 51.316 29.781 −22.494 1.00 21.05 B N ATOM 15504 CA SER B 447 50.692 28.808 −23.397 1.00 21.90 B C ATOM 15506 CB SER B 447 49.439 28.196 −22.759 1.00 22.29 B C ATOM 15509 OG SER B 447 49.766 27.644 −21.480 1.00 23.50 B O ATOM 15511 C SER B 447 50.398 29.439 −24.765 1.00 20.46 B C ATOM 15512 O SER B 447 50.526 28.757 −25.772 1.00 18.99 B O ATOM 15514 N HIS B 448 50.065 30.736 −24.809 1.00 18.56 B N ATOM 15515 CA HIS B 448 49.869 31.424 −26.102 1.00 19.59 B C ATOM 15517 CB HIS B 448 49.575 32.940 −25.943 1.00 20.25 B C ATOM 15520 CG HIS B 448 48.262 33.260 −25.299 1.00 17.92 B C ATOM 15521 ND1 HIS B 448 47.442 32.305 −24.739 1.00 28.87 B N ATOM 15523 CE1 HIS B 448 46.352 32.881 −24.262 1.00 28.11 B C ATOM 15525 NE2 HIS B 448 46.445 34.180 −24.475 1.00 27.76 B N ATOM 15527 CD2 HIS B 448 47.635 34.443 −25.110 1.00 27.89 B C ATOM 15529 C HIS B 448 51.144 31.279 −26.940 1.00 20.44 B C ATOM 15530 O HIS B 448 51.091 30.897 −28.104 1.00 22.27 B O ATOM 15532 N ILE B 449 52.280 31.587 −26.330 1.00 21.15 B N ATOM 15533 CA ILE B 449 53.582 31.551 −26.989 1.00 22.39 B C ATOM 15535 CB ILE B 449 54.724 32.020 −26.038 1.00 24.30 B C ATOM 15537 CG1 ILE B 449 54.491 33.446 −25.519 1.00 23.85 B C ATOM 15540 CD1 ILE B 449 54.478 34.442 −26.532 1.00 25.54 B C ATOM 15544 CG2 ILE B 449 56.112 31.942 −26.722 1.00 18.30 B C ATOM 15548 C ILE B 449 53.927 30.142 −27.449 1.00 22.56 B C ATOM 15549 O ILE B 449 54.427 29.944 −28.551 1.00 24.34 B O ATOM 15551 N PHE B 450 53.688 29.163 −26.586 1.00 23.02 B N ATOM 15552 CA PHE B 450 53.918 27.756 −26.916 1.00 21.54 B C ATOM 15554 CB PHE B 450 53.473 26.918 −25.716 1.00 23.75 B C ATOM 15557 CG PHE B 450 53.594 25.410 −25.887 1.00 24.61 B C ATOM 15558 CD1 PHE B 450 54.374 24.827 −26.878 1.00 26.66 B C ATOM 15560 CE1 PHE B 450 54.457 23.457 −26.978 1.00 27.03 B C ATOM 15562 CZ PHE B 450 53.801 22.643 −26.064 1.00 24.83 B C ATOM 15564 CE2 PHE B 450 53.052 23.206 −25.056 1.00 28.16 B C ATOM 15566 CD2 PHE B 450 52.960 24.581 −24.968 1.00 24.61 B C ATOM 15568 C PHE B 450 53.191 27.358 −28.205 1.00 20.99 B C ATOM 15569 O PHE B 450 53.819 26.924 −29.186 1.00 21.24 B O ATOM 15571 N ARG B 451 51.884 27.569 −28.229 1.00 19.94 B N ATOM 15572 CA ARG B 451 51.098 27.288 −29.420 1.00 20.74 B C ATOM 15574 CB ARG B 451 49.621 27.595 −29.169 1.00 22.47 B C ATOM 15577 CG ARG B 451 48.730 27.505 −30.419 1.00 25.35 B C ATOM 15580 CD ARG B 451 48.936 26.192 −31.191 1.00 23.31 B C ATOM 15583 NE ARG B 451 48.475 25.041 −30.448 1.00 19.56 B N ATOM 15585 CZ ARG B 451 48.731 23.772 −30.790 1.00 23.42 B C ATOM 15586 NH1 ARG B 451 49.495 23.478 −31.840 1.00 19.04 B N ATOM 15589 NH2 ARG B 451 48.232 22.788 −30.062 1.00 18.74 B N ATOM 15592 C ARG B 451 51.588 28.065 −30.632 1.00 19.72 B C ATOM 15593 O ARG B 451 51.806 27.489 −31.685 1.00 19.96 B O ATOM 15595 N LEU B 452 51.786 29.369 −30.495 1.00 21.57 B N ATOM 15596 CA LEU B 452 52.199 30.177 −31.659 1.00 20.99 B C ATOM 15598 CB LEU B 452 52.191 31.663 −31.330 1.00 18.72 B C ATOM 15601 CG LEU B 452 50.805 32.248 −31.082 1.00 18.91 B C ATOM 15603 CD1 LEU B 452 50.863 33.633 −30.405 1.00 15.37 B C ATOM 15607 CD2 LEU B 452 50.033 32.299 −32.401 1.00 22.45 B C ATOM 15611 C LEU B 452 53.557 29.757 −32.201 1.00 21.75 B C ATOM 15612 O LEU B 452 53.753 29.726 −33.427 1.00 24.82 B O ATOM 15614 N CYS B 453 54.513 29.472 −31.315 1.00 22.18 B N ATOM 15615 CA CYS B 453 55.844 29.031 −31.758 1.00 22.41 B C ATOM 15617 CB CYS B 453 56.801 28.918 −30.589 1.00 25.19 B C ATOM 15620 SG CYS B 453 57.373 30.478 −29.922 1.00 28.92 B S ATOM 15622 C CYS B 453 55.744 27.682 −32.476 1.00 23.45 B C ATOM 15623 O CYS B 453 56.283 27.514 −33.545 1.00 25.24 B O ATOM 15625 N ASN B 454 55.004 26.743 −31.901 1.00 23.96 B N ATOM 15626 CA ASN B 454 54.755 25.463 −32.555 1.00 25.23 B C ATOM 15628 CB ASN B 454 53.889 24.583 −31.643 1.00 25.52 B C ATOM 15631 CG ASN B 454 53.627 23.178 −32.218 1.00 30.70 B C ATOM 15632 OD1 ASN B 454 54.124 22.811 −33.295 1.00 41.50 B O ATOM 15633 ND2 ASN B 454 52.848 22.382 −31.480 1.00 30.45 B N ATOM 15636 C ASN B 454 54.103 25.614 −33.935 1.00 26.69 B C ATOM 15637 O ASN B 454 54.551 25.039 −34.924 1.00 25.94 B O ATOM 15639 N ASP B 455 53.039 26.393 −34.006 1.00 25.79 B N ATOM 15640 CA ASP B 455 52.334 26.528 −35.265 1.00 24.91 B C ATOM 15642 CB ASP B 455 50.983 27.213 −35.077 1.00 24.32 B C ATOM 15645 CG ASP B 455 49.932 26.296 −34.475 1.00 27.79 B C ATOM 15646 OD1 ASP B 455 50.267 25.171 −34.053 1.00 23.64 B O ATOM 15647 OD2 ASP B 455 48.753 26.715 −34.422 1.00 29.77 B O ATOM 15648 C ASP B 455 53.169 27.290 −36.278 1.00 25.89 B C ATOM 15649 O ASP B 455 53.081 27.002 −37.471 1.00 26.97 B O ATOM 15651 N LEU B 456 53.950 28.267 −35.829 1.00 25.05 B N ATOM 15652 CA LEU B 456 54.864 28.975 −36.734 1.00 27.30 B C ATOM 15654 CB LEU B 456 55.706 30.009 −35.981 1.00 28.50 B C ATOM 15657 CG LEU B 456 55.165 31.412 −35.754 1.00 31.82 B C ATOM 15659 CD1 LEU B 456 56.033 32.147 −34.720 1.00 27.46 B C ATOM 15663 CD2 LEU B 456 55.143 32.136 −37.066 1.00 27.67 B C ATOM 15667 C LEU B 456 55.831 27.999 −37.417 1.00 29.38 B C ATOM 15668 O LEU B 456 56.116 28.138 −38.610 1.00 27.77 B O ATOM 15670 N ALA B 457 56.332 27.022 −36.653 1.00 29.83 B N ATOM 15671 CA ALA B 457 57.349 26.087 −37.157 1.00 31.91 B C ATOM 15673 CB ALA B 457 58.006 25.277 −35.983 1.00 28.83 B C ATOM 15677 C ALA B 457 56.801 25.140 −38.232 1.00 32.51 B C ATOM 15678 O ALA B 457 57.519 24.802 −39.166 1.00 34.24 B O ATOM 15680 N SER B 458 55.541 24.723 −38.123 1.00 33.79 B N ATOM 15681 CA SER B 458 54.957 23.822 −39.135 1.00 34.87 B C ATOM 15683 CB SER B 458 54.113 22.751 −38.446 1.00 34.97 B C ATOM 15686 OG SER B 458 53.080 23.347 −37.693 1.00 39.44 B O ATOM 15688 C SER B 458 54.094 24.531 −40.189 1.00 33.97 B C ATOM 15689 O SER B 458 53.555 23.888 −41.097 1.00 34.54 B O ATOM 15691 N ALA B 459 53.951 25.845 −40.077 1.00 34.50 B N ATOM 15692 CA ALA B 459 52.971 26.580 −40.907 1.00 33.99 B C ATOM 15694 CB ALA B 459 53.033 28.075 −40.597 1.00 31.89 B C ATOM 15698 C ALA B 459 53.174 26.357 −42.408 1.00 35.22 B C ATOM 15699 O ALA B 459 52.247 25.966 −43.129 1.00 33.66 B O ATOM 15701 N SER B 460 54.386 26.616 −42.878 1.00 37.80 B N ATOM 15702 CA SER B 460 54.671 26.532 −44.308 1.00 42.19 B C ATOM 15704 CB SER B 460 56.131 26.863 −44.593 1.00 41.81 B C ATOM 15707 OG SER B 460 56.959 25.873 −44.007 1.00 52.01 B O ATOM 15709 C SER B 460 54.306 25.164 −44.903 1.00 42.35 B C ATOM 15710 O SER B 460 53.632 25.107 −45.925 1.00 43.43 B O ATOM 15712 N ALA B 461 54.718 24.073 −44.264 1.00 42.83 B N ATOM 15713 CA ALA B 461 54.384 22.738 −44.780 1.00 42.85 B C ATOM 15715 CB ALA B 461 55.110 21.645 −44.000 1.00 42.43 B C ATOM 15719 C ALA B 461 52.881 22.504 −44.737 1.00 43.66 B C ATOM 15720 O ALA B 461 52.300 22.003 −45.696 1.00 44.63 B O ATOM 15722 N GLU B 462 52.253 22.884 −43.627 1.00 43.99 B N ATOM 15723 CA GLU B 462 50.839 22.611 −43.422 1.00 43.23 B C ATOM 15725 CB GLU B 462 50.439 22.868 −41.960 1.00 43.40 B C ATOM 15728 CG GLU B 462 51.049 21.826 −40.996 1.00 44.25 B C ATOM 15731 CD GLU B 462 50.581 21.932 −39.541 1.00 47.19 B C ATOM 15732 OE1 GLU B 462 49.667 22.724 −39.235 1.00 52.18 B O ATOM 15733 OE2 GLU B 462 51.140 21.208 −38.685 1.00 50.84 B O ATOM 15734 C GLU B 462 49.979 23.397 −44.405 1.00 43.66 B C ATOM 15735 O GLU B 462 48.979 22.885 −44.919 1.00 43.54 B O ATOM 15737 N ILE B 463 50.388 24.624 −44.701 1.00 43.85 B N ATOM 15738 CA ILE B 463 49.678 25.443 −45.670 1.00 43.45 B C ATOM 15740 CB ILE B 463 50.147 26.910 −45.599 1.00 42.49 B C ATOM 15742 CG1 ILE B 463 49.640 27.547 −44.298 1.00 43.11 B C ATOM 15745 CD1 ILE B 463 50.272 28.903 −43.970 1.00 34.75 B C ATOM 15749 CG2 ILE B 463 49.658 27.714 −46.809 1.00 40.80 B C ATOM 15753 C ILE B 463 49.836 24.863 −47.086 1.00 46.39 B C ATOM 15754 O ILE B 463 48.888 24.891 −47.885 1.00 48.52 B O ATOM 15756 N ALA B 464 51.016 24.324 −47.387 1.00 47.05 B N ATOM 15757 CA ALA B 464 51.302 23.784 −48.719 1.00 48.40 B C ATOM 15759 CB ALA B 464 52.809 23.523 −48.896 1.00 46.81 B C ATOM 15763 C ALA B 464 50.489 22.516 −48.985 1.00 49.19 B C ATOM 15764 O ALA B 464 50.121 22.260 −50.125 1.00 49.95 B O ATOM 15766 N ARG B 465 50.195 21.739 −47.941 1.00 49.76 B N ATOM 15767 CA ARG B 465 49.306 20.569 −48.075 1.00 51.15 B C ATOM 15769 CB ARG B 465 49.490 19.572 −46.925 1.00 51.61 B C ATOM 15772 CG ARG B 465 50.880 18.967 −46.767 1.00 55.53 B C ATOM 15775 CD ARG B 465 50.935 18.153 −45.476 1.00 58.91 B C ATOM 15778 NE ARG B 465 52.181 18.367 −44.734 1.00 65.49 B N ATOM 15780 CZ ARG B 465 52.308 18.305 −43.404 1.00 67.24 B C ATOM 15781 NH1 ARG B 465 51.261 18.048 −42.620 1.00 67.28 B N ATOM 15784 NH2 ARG B 465 53.500 18.517 −42.849 1.00 67.61 B N ATOM 15787 C ARG B 465 47.831 20.956 −48.095 1.00 51.06 B C ATOM 15788 O ARG B 465 46.971 20.082 −48.199 1.00 50.83 B O ATOM 15790 N GLY B 466 47.533 22.247 −47.958 1.00 50.91 B N ATOM 15791 CA GLY B 466 46.152 22.716 −47.896 1.00 50.39 B C ATOM 15794 C GLY B 466 45.486 22.489 −46.547 1.00 49.96 B C ATOM 15795 O GLY B 466 44.259 22.509 −46.466 1.00 48.27 B O ATOM 15797 N GLU B 467 46.279 22.272 −45.492 1.00 48.91 B N ATOM 15798 CA GLU B 467 45.730 22.134 −44.139 1.00 48.83 B C ATOM 15800 CB GLU B 467 46.683 21.365 −43.215 1.00 50.22 B C ATOM 15803 CG GLU B 467 46.967 19.930 −43.661 1.00 54.30 B C ATOM 15806 CD GLU B 467 47.790 19.116 −42.653 1.00 62.14 B C ATOM 15807 OE1 GLU B 467 47.867 19.491 −41.458 1.00 59.06 B O ATOM 15808 OE2 GLU B 467 48.354 18.078 −43.069 1.00 67.03 B O ATOM 15809 C GLU B 467 45.424 23.515 −43.548 1.00 47.13 B C ATOM 15810 O GLU B 467 46.114 24.497 −43.847 1.00 47.48 B O ATOM 15812 N THR B 468 44.375 23.586 −42.732 1.00 42.97 B N ATOM 15813 CA THR B 468 43.954 24.835 −42.125 1.00 40.67 B C ATOM 15815 CB THR B 468 42.508 25.173 −42.518 1.00 42.48 B C ATOM 15817 OG1 THR B 468 41.661 24.045 −42.263 1.00 42.18 B O ATOM 15819 CG2 THR B 468 42.418 25.574 −43.978 1.00 40.21 B C ATOM 15823 C THR B 468 44.074 24.847 −40.585 1.00 38.82 B C ATOM 15824 O THR B 468 43.912 25.902 −39.956 1.00 36.40 B O ATOM 15826 N ALA B 469 44.376 23.688 −39.996 1.00 36.08 B N ATOM 15827 CA ALA B 469 44.455 23.532 −38.542 1.00 35.79 B C ATOM 15829 CB ALA B 469 44.222 22.068 −38.167 1.00 35.44 B C ATOM 15833 C ALA B 469 45.812 24.041 −38.008 1.00 33.99 B C ATOM 15834 O ALA B 469 46.668 23.262 −37.602 1.00 35.58 B O ATOM 15836 N ASN B 470 45.972 25.363 −38.014 1.00 30.53 B N ATOM 15837 CA ASN B 470 47.231 26.025 −37.741 1.00 25.50 B C ATOM 15839 CB ASN B 470 48.175 25.826 −38.924 1.00 24.65 B C ATOM 15842 CG ASN B 470 49.538 26.437 −38.688 1.00 24.87 B C ATOM 15843 OD1 ASN B 470 49.730 27.634 −38.868 1.00 29.42 B O ATOM 15844 ND2 ASN B 470 50.501 25.609 −38.281 1.00 29.64 B N ATOM 15847 C ASN B 470 46.974 27.515 −37.559 1.00 24.47 B C ATOM 15848 O ASN B 470 46.291 28.128 −38.365 1.00 25.58 B O ATOM 15850 N SER B 471 47.564 28.104 −36.536 1.00 23.87 B N ATOM 15851 CA SER B 471 47.303 29.492 −36.181 1.00 22.68 B C ATOM 15853 CB SER B 471 48.100 29.848 −34.917 1.00 23.21 B C ATOM 15856 OG SER B 471 47.655 29.026 −33.835 1.00 25.29 B O ATOM 15858 C SER B 471 47.606 30.484 −37.296 1.00 22.53 B C ATOM 15859 O SER B 471 46.853 31.454 −37.500 1.00 18.89 B O ATOM 15861 N VAL B 472 48.692 30.241 −38.031 1.00 22.65 B N ATOM 15862 CA VAL B 472 49.105 31.147 −39.088 1.00 21.42 B C ATOM 15864 CB VAL B 472 50.518 30.828 −39.641 1.00 21.25 B C ATOM 15866 CG1 VAL B 472 50.905 31.826 −40.704 1.00 17.98 B C ATOM 15870 CG2 VAL B 472 51.546 30.823 −38.538 1.00 20.99 B C ATOM 15874 C VAL B 472 48.090 31.055 −40.204 1.00 21.80 B C ATOM 15875 O VAL B 472 47.694 32.062 −40.783 1.00 22.50 B O ATOM 15877 N SER B 473 47.659 29.841 −40.498 1.00 24.12 B N ATOM 15878 CA SER B 473 46.680 29.630 −41.544 1.00 25.40 B C ATOM 15880 CB SER B 473 46.400 28.146 −41.745 1.00 26.05 B C ATOM 15883 OG SER B 473 45.232 27.940 −42.515 1.00 32.34 B O ATOM 15885 C SER B 473 45.400 30.375 −41.202 1.00 24.34 B C ATOM 15886 O SER B 473 44.847 31.051 −42.064 1.00 23.63 B O ATOM 15888 N CYS B 474 44.921 30.280 −39.960 1.00 23.27 B N ATOM 15889 CA CYS B 474 43.642 30.961 −39.612 1.00 24.54 B C ATOM 15891 CB CYS B 474 43.162 30.643 −38.196 1.00 26.93 B C ATOM 15894 SG CYS B 474 42.488 29.053 −38.026 1.00 32.90 B S ATOM 15896 C CYS B 474 43.784 32.442 −39.678 1.00 22.35 B C ATOM 15897 O CYS B 474 42.866 33.138 −40.073 1.00 25.09 B O ATOM 15899 N TYR B 475 44.934 32.933 −39.257 1.00 21.83 B N ATOM 15900 CA TYR B 475 45.190 34.340 −39.332 1.00 22.48 B C ATOM 15902 CB TYR B 475 46.530 34.700 −38.700 1.00 21.91 B C ATOM 15905 CG TYR B 475 46.519 36.065 −38.080 1.00 23.95 B C ATOM 15906 CD1 TYR B 475 46.386 36.237 −36.704 1.00 34.09 B C ATOM 15908 CE1 TYR B 475 46.373 37.512 −36.136 1.00 35.55 B C ATOM 15910 CZ TYR B 475 46.497 38.611 −36.954 1.00 34.14 B C ATOM 15911 OH TYR B 475 46.491 39.895 −36.448 1.00 48.07 B O ATOM 15913 CE2 TYR B 475 46.635 38.456 −38.307 1.00 35.92 B C ATOM 15915 CD2 TYR B 475 46.644 37.188 −38.863 1.00 31.67 B C ATOM 15917 C TYR B 475 45.105 34.802 −40.780 1.00 22.81 B C ATOM 15918 O TYR B 475 44.474 35.831 −41.063 1.00 21.86 B O ATOM 15920 N MET B 476 45.690 34.038 −41.702 1.00 23.95 B N ATOM 15921 CA MET B 476 45.575 34.362 −43.138 1.00 23.98 B C ATOM 15923 CB MET B 476 46.227 33.304 −44.022 1.00 23.03 B C ATOM 15926 CG MET B 476 47.734 33.236 −43.917 1.00 31.57 B C ATOM 15929 SD MET B 476 48.370 31.791 −44.783 1.00 35.82 B S ATOM 15930 CE MET B 476 47.693 31.997 −46.420 1.00 24.22 B C ATOM 15934 C MET B 476 44.141 34.491 −43.607 1.00 23.68 B C ATOM 15935 O MET B 476 43.773 35.478 −44.264 1.00 22.64 B O ATOM 15937 N ARG B 477 43.345 33.465 −43.322 1.00 25.52 B N ATOM 15938 CA ARG B 477 41.970 33.395 −43.827 1.00 25.98 B C ATOM 15940 CB ARG B 477 41.428 31.967 −43.725 1.00 26.64 B C ATOM 15943 CG ARG B 477 42.138 31.022 −44.683 1.00 33.11 B C ATOM 15946 CD ARG B 477 41.835 29.543 −44.464 1.00 39.31 B C ATOM 15949 NE ARG B 477 42.179 29.067 −43.121 1.00 44.33 B N ATOM 15951 CZ ARG B 477 41.305 28.880 −42.129 1.00 46.94 B C ATOM 15952 NH1 ARG B 477 40.009 29.127 −42.300 1.00 48.55 B N ATOM 15955 NH2 ARG B 477 41.736 28.447 −40.947 1.00 49.68 B N ATOM 15958 C ARG B 477 41.058 34.367 −43.100 1.00 25.86 B C ATOM 15959 O ARG B 477 40.157 34.945 −43.720 1.00 28.90 B O ATOM 15961 N THR B 478 41.277 34.546 −41.797 1.00 24.19 B N ATOM 15962 CA THR B 478 40.461 35.474 −41.024 1.00 25.34 B C ATOM 15964 CB THR B 478 40.684 35.343 −39.479 1.00 25.12 B C ATOM 15966 OG1 THR B 478 40.006 34.185 −38.996 1.00 20.79 B O ATOM 15968 CG2 THR B 478 40.152 36.574 −38.707 1.00 21.35 B C ATOM 15972 C THR B 478 40.692 36.916 −41.477 1.00 25.19 B C ATOM 15973 O THR B 478 39.741 37.646 −41.606 1.00 24.19 B O ATOM 15975 N LYS B 479 41.944 37.316 −41.698 1.00 25.64 B N ATOM 15976 CA LYS B 479 42.261 38.694 −42.081 1.00 27.05 B C ATOM 15978 CB LYS B 479 43.538 39.169 −41.392 1.00 28.04 B C ATOM 15981 CG LYS B 479 43.434 39.286 −39.858 1.00 32.43 B C ATOM 15984 CD LYS B 479 42.899 40.662 −39.421 1.00 41.92 B C ATOM 15987 CE LYS B 479 42.652 40.733 −37.915 1.00 48.99 B C ATOM 15990 NZ LYS B 479 42.370 42.129 −37.475 1.00 48.92 B N ATOM 15994 C LYS B 479 42.368 38.915 −43.593 1.00 28.30 B C ATOM 15995 O LYS B 479 42.444 40.064 −44.042 1.00 30.46 B O ATOM 15997 N GLY B 480 42.335 37.844 −44.384 1.00 27.75 B N ATOM 15998 CA GLY B 480 42.483 37.962 −45.838 1.00 27.63 B C ATOM 16001 C GLY B 480 43.873 38.401 −46.270 1.00 27.82 B C ATOM 16002 O GLY B 480 44.014 39.224 −47.167 1.00 28.13 B O ATOM 16004 N ILE B 481 44.910 37.846 −45.638 1.00 27.16 B N ATOM 16005 CA ILE B 481 46.294 38.221 −45.964 1.00 27.84 B C ATOM 16007 CB ILE B 481 46.978 39.002 −44.812 1.00 27.50 B C ATOM 16009 CG1 ILE B 481 47.018 38.173 −43.515 1.00 26.34 B C ATOM 16012 CD1 ILE B 481 47.775 38.847 −42.350 1.00 23.73 B C ATOM 16016 CG2 ILE B 481 46.260 40.328 −44.607 1.00 27.59 B C ATOM 16020 C ILE B 481 47.138 37.024 −46.393 1.00 28.16 B C ATOM 16021 O ILE B 481 46.725 35.888 −46.255 1.00 30.84 B O ATOM 16023 N SER B 482 48.305 37.308 −46.954 1.00 30.02 B N ATOM 16024 CA SER B 482 49.283 36.301 −47.364 1.00 30.53 B C ATOM 16026 CB SER B 482 50.364 36.989 −48.173 1.00 30.13 B C ATOM 16029 OG SER B 482 50.971 37.996 −47.377 1.00 28.80 B O ATOM 16031 C SER B 482 49.968 35.638 −46.164 1.00 31.57 B C ATOM 16032 O SER B 482 50.006 36.209 −45.074 1.00 31.84 B O ATOM 16034 N GLU B 483 50.548 34.461 −46.390 1.00 30.45 B N ATOM 16035 CA GLU B 483 51.308 33.774 −45.371 1.00 31.95 B C ATOM 16037 CB GLU B 483 51.969 32.521 −45.952 1.00 32.69 B C ATOM 16040 CG GLU B 483 52.874 31.797 −44.939 1.00 35.01 B C ATOM 16043 CD GLU B 483 53.216 30.353 −45.314 1.00 41.67 B C ATOM 16044 OE1 GLU B 483 52.776 29.875 −46.389 1.00 39.44 B O ATOM 16045 OE2 GLU B 483 53.939 29.701 −44.511 1.00 39.15 B O ATOM 16046 C GLU B 483 52.353 34.672 −44.706 1.00 32.33 B C ATOM 16047 O GLU B 483 52.486 34.704 −43.482 1.00 33.44 B O ATOM 16049 N GLU B 484 53.073 35.412 −45.522 1.00 33.10 B N ATOM 16050 CA GLU B 484 54.133 36.271 −45.054 1.00 35.44 B C ATOM 16052 CB GLU B 484 54.806 36.958 −46.254 1.00 37.40 B C ATOM 16055 CG GLU B 484 56.049 37.754 −45.888 1.00 47.37 B C ATOM 16058 CD GLU B 484 56.678 38.484 −47.076 1.00 61.47 B C ATOM 16059 OE1 GLU B 484 56.049 38.576 −48.162 1.00 64.59 B O ATOM 16060 OE2 GLU B 484 57.815 38.975 −46.906 1.00 63.79 B O ATOM 16061 C GLU B 484 53.636 37.330 −44.064 1.00 33.41 B C ATOM 16062 O GLU B 484 54.285 37.580 −43.049 1.00 30.95 B O ATOM 16064 N LEU B 485 52.516 37.974 −44.375 1.00 31.70 B N ATOM 16065 CA LEU B 485 51.982 39.005 −43.489 1.00 31.52 B C ATOM 16067 CB LEU B 485 50.969 39.899 −44.218 1.00 33.56 B C ATOM 16070 CG LEU B 485 51.561 40.942 −45.174 1.00 37.32 B C ATOM 16072 CD1 LEU B 485 50.509 41.463 −46.157 1.00 36.05 B C ATOM 16076 CD2 LEU B 485 52.180 42.087 −44.377 1.00 42.57 B C ATOM 16080 C LEU B 485 51.360 38.383 −42.229 1.00 28.30 B C ATOM 16081 O LEU B 485 51.426 38.957 −41.157 1.00 25.25 B O ATOM 16083 N ALA B 486 50.782 37.201 −42.367 1.00 26.73 B N ATOM 16084 CA ALA B 486 50.173 36.528 −41.243 1.00 26.36 B C ATOM 16086 CB ALA B 486 49.358 35.304 −41.718 1.00 23.95 B C ATOM 16090 C ALA B 486 51.281 36.134 −40.269 1.00 24.95 B C ATOM 16091 O ALA B 486 51.141 36.267 −39.048 1.00 22.96 B O ATOM 16093 N THR B 487 52.397 35.706 −40.835 1.00 25.77 B N ATOM 16094 CA THR B 487 53.581 35.312 −40.069 1.00 27.48 B C ATOM 16096 CB THR B 487 54.654 34.714 −41.004 1.00 29.14 B C ATOM 16098 OG1 THR B 487 54.120 33.537 −41.647 1.00 29.56 B O ATOM 16100 CG2 THR B 487 55.884 34.343 −40.234 1.00 24.58 B C ATOM 16104 C THR B 487 54.142 36.492 −39.306 1.00 26.57 B C ATOM 16105 O THR B 487 54.450 36.400 −38.119 1.00 22.40 B O ATOM 16107 N GLU B 488 54.225 37.624 −39.977 1.00 28.65 B N ATOM 16108 CA GLU B 488 54.627 38.869 −39.311 1.00 31.12 B C ATOM 16110 CB GLU B 488 54.701 40.012 −40.336 1.00 33.28 B C ATOM 16113 CG GLU B 488 55.304 41.334 −39.844 1.00 43.15 B C ATOM 16116 CD GLU B 488 55.275 42.458 −40.908 1.00 50.77 B C ATOM 16117 OE1 GLU B 488 54.732 42.270 −42.023 1.00 51.52 B O ATOM 16118 OE2 GLU B 488 55.802 43.548 −40.611 1.00 57.46 B O ATOM 16119 C GLU B 488 53.669 39.187 −38.131 1.00 28.39 B C ATOM 16120 O GLU B 488 54.129 39.472 −37.027 1.00 25.62 B O ATOM 16122 N SER B 489 52.354 39.090 −38.351 1.00 25.99 B N ATOM 16123 CA SER B 489 51.379 39.404 −37.281 1.00 27.20 B C ATOM 16125 CB SER B 489 49.923 39.418 −37.770 1.00 24.76 B C ATOM 16128 OG SER B 489 49.709 40.444 −38.695 1.00 30.59 B O ATOM 16130 C SER B 489 51.473 38.435 −36.118 1.00 25.26 B C ATOM 16131 O SER B 489 51.327 38.835 −34.979 1.00 25.76 B O ATOM 16133 N VAL B 490 51.703 37.165 −36.401 1.00 24.32 B N ATOM 16134 CA VAL B 490 51.890 36.201 −35.318 1.00 24.64 B C ATOM 16136 CB VAL B 490 51.905 34.758 −35.847 1.00 24.98 B C ATOM 16138 CG1 VAL B 490 52.313 33.755 −34.747 1.00 24.04 B C ATOM 16142 CG2 VAL B 490 50.555 34.409 −36.395 1.00 20.83 B C ATOM 16146 C VAL B 490 53.133 36.517 −34.465 1.00 25.21 B C ATOM 16147 O VAL B 490 53.084 36.405 −33.252 1.00 26.85 B O ATOM 16149 N MET B 491 54.221 36.962 −35.085 1.00 27.17 B N ATOM 16150 CA MET B 491 55.441 37.314 −34.345 1.00 27.17 B C ATOM 16152 CB MET B 491 56.619 37.595 −35.286 1.00 29.59 B C ATOM 16155 CG MET B 491 56.984 36.475 −36.254 1.00 32.48 B C ATOM 16158 SD MET B 491 58.082 35.259 −35.532 1.00 54.54 B S ATOM 16159 CE MET B 491 58.676 34.476 −37.042 1.00 58.30 B C ATOM 16163 C MET B 491 55.183 38.545 −33.498 1.00 26.01 B C ATOM 16164 O MET B 491 55.677 38.646 −32.387 1.00 27.29 B O ATOM 16166 N ASN B 492 54.414 39.494 −34.024 1.00 25.33 B N ATOM 16167 CA ASN B 492 54.027 40.675 −33.241 1.00 25.11 B C ATOM 16169 CB ASN B 492 53.294 41.713 −34.100 1.00 26.44 B C ATOM 16172 CG ASN B 492 54.206 42.393 −35.135 1.00 31.18 B C ATOM 16173 OD1 ASN B 492 55.413 42.496 −34.944 1.00 41.61 B O ATOM 16174 ND2 ASN B 492 53.610 42.884 −36.226 1.00 31.04 B N ATOM 16177 C ASN B 492 53.163 40.308 −32.025 1.00 21.95 B C ATOM 16178 O ASN B 492 53.310 40.913 −30.977 1.00 23.50 B O ATOM 16180 N LEU B 493 52.272 39.332 −32.176 1.00 16.94 B N ATOM 16181 CA LEU B 493 51.452 38.837 −31.078 1.00 19.50 B C ATOM 16183 CB LEU B 493 50.401 37.871 −31.626 1.00 20.12 B C ATOM 16186 CG LEU B 493 49.330 37.252 −30.730 1.00 29.36 B C ATOM 16188 CD1 LEU B 493 48.557 38.309 −29.904 1.00 28.24 B C ATOM 16192 CD2 LEU B 493 48.355 36.399 −31.599 1.00 21.19 B C ATOM 16196 C LEU B 493 52.359 38.162 −30.021 1.00 19.84 B C ATOM 16197 O LEU B 493 52.219 38.393 −28.819 1.00 19.40 B O ATOM 16199 N ILE B 494 53.326 37.380 −30.477 1.00 20.01 B N ATOM 16200 CA ILE B 494 54.330 36.845 −29.569 1.00 20.75 B C ATOM 16202 CB ILE B 494 55.346 35.966 −30.315 1.00 20.42 B C ATOM 16204 CG1 ILE B 494 54.646 34.675 −30.739 1.00 16.69 B C ATOM 16207 CD1 ILE B 494 55.474 33.814 −31.610 1.00 19.06 B C ATOM 16211 CG2 ILE B 494 56.521 35.613 −29.418 1.00 20.38 B C ATOM 16215 C ILE B 494 55.009 37.965 −28.770 1.00 20.30 B C ATOM 16216 O ILE B 494 55.087 37.890 −27.548 1.00 20.50 B O ATOM 16218 N ASP B 495 55.429 39.026 −29.442 1.00 20.29 B N ATOM 16219 CA ASP B 495 56.042 40.169 −28.763 1.00 20.00 B C ATOM 16221 CB ASP B 495 56.476 41.235 −29.773 1.00 19.65 B C ATOM 16224 CG ASP B 495 57.672 40.795 −30.609 1.00 22.70 B C ATOM 16225 OD1 ASP B 495 58.358 39.819 −30.243 1.00 32.40 B O ATOM 16226 OD2 ASP B 495 57.943 41.429 −31.644 1.00 33.90 B O ATOM 16227 C ASP B 495 55.140 40.800 −27.717 1.00 22.04 B C ATOM 16228 O ASP B 495 55.567 41.053 −26.588 1.00 23.10 B O ATOM 16230 N GLU B 496 53.897 41.061 −28.088 1.00 23.21 B N ATOM 16231 CA GLU B 496 52.959 41.715 −27.191 1.00 25.03 B C ATOM 16233 CB GLU B 496 51.643 42.007 −27.902 1.00 24.60 B C ATOM 16236 CG GLU B 496 51.772 43.101 −28.938 1.00 34.66 B C ATOM 16239 CD GLU B 496 52.250 44.433 −28.354 1.00 43.94 B C ATOM 16240 OE1 GLU B 496 53.248 44.980 −28.880 1.00 45.89 B O ATOM 16241 OE2 GLU B 496 51.633 44.926 −27.377 1.00 48.24 B O ATOM 16242 C GLU B 496 52.693 40.840 −26.003 1.00 23.68 B C ATOM 16243 O GLU B 496 52.579 41.339 −24.882 1.00 23.34 B O ATOM 16245 N THR B 497 52.606 39.534 −26.257 1.00 21.60 B N ATOM 16246 CA THR B 497 52.340 38.571 −25.214 1.00 21.88 B C ATOM 16248 CB THR B 497 52.112 37.168 −25.799 1.00 22.84 B C ATOM 16250 OG1 THR B 497 51.067 37.231 −26.790 1.00 24.32 B O ATOM 16252 CG2 THR B 497 51.719 36.222 −24.710 1.00 18.88 B C ATOM 16256 C THR B 497 53.510 38.565 −24.217 1.00 21.49 B C ATOM 16257 O THR B 497 53.295 38.521 −23.022 1.00 20.84 B O ATOM 16259 N TRP B 498 54.737 38.654 −24.715 1.00 19.80 B N ATOM 16260 CA TRP B 498 55.892 38.786 −23.847 1.00 21.21 B C ATOM 16262 CB TRP B 498 57.194 38.771 −24.641 1.00 20.21 B C ATOM 16265 CG TRP B 498 57.821 37.406 −24.729 1.00 22.28 B C ATOM 16266 CD1 TRP B 498 57.768 36.547 −25.786 1.00 18.79 B C ATOM 16268 NE1 TRP B 498 58.454 35.404 −25.497 1.00 23.07 B N ATOM 16270 CE2 TRP B 498 58.985 35.508 −24.241 1.00 18.89 B C ATOM 16271 CD2 TRP B 498 58.603 36.756 −23.726 1.00 23.52 B C ATOM 16272 CE3 TRP B 498 59.019 37.107 −22.439 1.00 25.36 B C ATOM 16274 CZ3 TRP B 498 59.775 36.204 −21.715 1.00 24.20 B C ATOM 16276 CH2 TRP B 498 60.147 34.974 −22.259 1.00 20.69 B C ATOM 16278 CZ2 TRP B 498 59.759 34.607 −23.516 1.00 25.94 B C ATOM 16280 C TRP B 498 55.844 40.048 −22.992 1.00 21.86 B C ATOM 16281 O TRP B 498 56.199 40.028 −21.809 1.00 22.63 B O ATOM 16283 N LYS B 499 55.404 41.147 −23.576 1.00 22.03 B N ATOM 16284 CA LYS B 499 55.328 42.379 −22.823 1.00 22.69 B C ATOM 16286 CB LYS B 499 54.851 43.541 −23.692 1.00 23.12 B C ATOM 16289 CG LYS B 499 55.860 43.971 −24.779 1.00 19.45 B C ATOM 16292 CD LYS B 499 55.348 45.181 −25.597 1.00 20.45 B C ATOM 16295 CE LYS B 499 56.178 45.364 −26.882 1.00 24.37 B C ATOM 16298 NZ LYS B 499 55.795 46.603 −27.636 1.00 25.22 B N ATOM 16302 C LYS B 499 54.438 42.197 −21.603 1.00 23.79 B C ATOM 16303 O LYS B 499 54.781 42.641 −20.506 1.00 26.86 B O ATOM 16305 N LYS B 500 53.332 41.492 −21.776 1.00 24.19 B N ATOM 16306 CA LYS B 500 52.421 41.226 −20.670 1.00 24.67 B C ATOM 16308 CB LYS B 500 51.083 40.762 −21.234 1.00 27.83 B C ATOM 16311 CG LYS B 500 50.405 41.905 −21.987 1.00 27.12 B C ATOM 16314 CD LYS B 500 49.172 41.461 −22.733 1.00 34.50 B C ATOM 16317 CE LYS B 500 48.524 42.638 −23.450 1.00 34.28 B C ATOM 16320 NZ LYS B 500 47.799 42.149 −24.632 1.00 42.60 B N ATOM 16324 C LYS B 500 52.951 40.237 −19.628 1.00 23.00 B C ATOM 16325 O LYS B 500 52.735 40.416 −18.443 1.00 24.58 B O ATOM 16327 N MET B 501 53.669 39.208 −20.055 1.00 22.99 B N ATOM 16328 CA MET B 501 54.321 38.326 −19.099 1.00 20.54 B C ATOM 16330 CB MET B 501 55.005 37.163 −19.801 1.00 20.14 B C ATOM 16333 CG MET B 501 54.036 36.223 −20.472 1.00 24.64 B C ATOM 16336 SD MET B 501 54.785 34.668 −21.007 1.00 29.22 B S ATOM 16337 CE MET B 501 56.131 35.198 −22.016 1.00 26.22 B C ATOM 16341 C MET B 501 55.330 39.112 −18.278 1.00 19.87 B C ATOM 16342 O MET B 501 55.398 38.941 −17.069 1.00 23.88 B O ATOM 16344 N ASN B 502 56.096 39.979 −18.928 1.00 18.65 B N ATOM 16345 CA ASN B 502 57.129 40.749 −18.260 1.00 19.97 B C ATOM 16347 CB ASN B 502 57.837 41.683 −19.265 1.00 18.67 B C ATOM 16350 CG ASN B 502 58.811 40.958 −20.196 1.00 22.60 B C ATOM 16351 OD1 ASN B 502 59.178 39.788 −19.987 1.00 22.42 B O ATOM 16352 ND2 ASN B 502 59.273 41.685 −21.224 1.00 16.81 B N ATOM 16355 C ASN B 502 56.523 41.576 −17.119 1.00 22.98 B C ATOM 16356 O ASN B 502 57.114 41.713 −16.027 1.00 24.16 B O ATOM 16358 N LYS B 503 55.342 42.136 −17.376 1.00 24.97 B N ATOM 16359 CA LYS B 503 54.643 42.934 −16.369 1.00 28.54 B C ATOM 16361 CB LYS B 503 53.493 43.719 −17.003 1.00 27.67 B C ATOM 16364 CG LYS B 503 52.638 44.472 −16.012 1.00 33.09 B C ATOM 16367 CD LYS B 503 51.658 45.394 −16.757 1.00 41.49 B C ATOM 16370 CE LYS B 503 50.925 46.355 −15.801 1.00 47.16 B C ATOM 16373 NZ LYS B 503 49.615 46.854 −16.376 1.00 45.45 B N ATOM 16377 C LYS B 503 54.141 42.058 −15.221 1.00 28.95 B C ATOM 16378 O LYS B 503 54.307 42.396 −14.056 1.00 30.69 B O ATOM 16380 N GLU B 504 53.522 40.938 −15.546 1.00 30.28 B N ATOM 16381 CA GLU B 504 53.101 39.983 −14.508 1.00 31.89 B C ATOM 16383 CB GLU B 504 52.551 38.690 −15.149 1.00 33.44 B C ATOM 16386 CG GLU B 504 51.701 37.808 −14.225 1.00 38.98 B C ATOM 16389 CD GLU B 504 50.382 38.465 −13.829 1.00 47.41 B C ATOM 16390 OE1 GLU B 504 49.897 38.183 −12.715 1.00 52.15 B O ATOM 16391 OE2 GLU B 504 49.841 39.277 −14.618 1.00 50.82 B O ATOM 16392 C GLU B 504 54.267 39.675 −13.555 1.00 29.72 B C ATOM 16393 O GLU B 504 54.119 39.732 −12.335 1.00 31.31 B O ATOM 16395 N LYS B 505 55.433 39.388 −14.114 1.00 28.05 B N ATOM 16396 CA LYS B 505 56.601 38.981 −13.323 1.00 27.17 B C ATOM 16398 CB LYS B 505 57.735 38.562 −14.266 1.00 25.64 B C ATOM 16401 CG LYS B 505 59.066 38.259 −13.594 1.00 26.00 B C ATOM 16404 CD LYS B 505 58.995 37.017 −12.710 1.00 25.01 B C ATOM 16407 CE LYS B 505 60.305 36.802 −11.941 1.00 22.47 B C ATOM 16410 NZ LYS B 505 61.449 36.651 −12.865 1.00 30.06 B N ATOM 16414 C LYS B 505 57.080 40.122 −12.423 1.00 29.79 B C ATOM 16415 O LYS B 505 57.422 39.943 −11.258 1.00 30.03 B O ATOM 16417 N LEU B 506 57.092 41.306 −12.993 1.00 33.92 B N ATOM 16418 CA LEU B 506 57.667 42.466 −12.352 1.00 37.31 B C ATOM 16420 CB LEU B 506 57.784 43.589 −13.383 1.00 37.37 B C ATOM 16423 CG LEU B 506 58.791 44.692 −13.143 1.00 42.52 B C ATOM 16425 CD1 LEU B 506 60.133 44.138 −12.685 1.00 39.23 B C ATOM 16429 CD2 LEU B 506 58.933 45.485 −14.443 1.00 47.19 B C ATOM 16433 C LEU B 506 56.838 42.932 −11.174 1.00 39.52 B C ATOM 16434 O LEU B 506 57.386 43.311 −10.144 1.00 40.98 B O ATOM 16436 N GLY B 507 55.521 42.894 −11.319 1.00 42.30 B N ATOM 16437 CA GLY B 507 54.656 43.514 −10.336 1.00 45.83 B C ATOM 16440 C GLY B 507 53.330 42.824 −10.120 1.00 49.02 B C ATOM 16441 O GLY B 507 52.686 42.354 −11.062 1.00 51.49 B O ATOM 16443 N GLY B 508 52.953 42.755 −8.846 1.00 51.72 B N ATOM 16444 CA GLY B 508 51.591 42.445 −8.415 1.00 52.78 B C ATOM 16447 C GLY B 508 50.900 41.218 −8.984 1.00 51.93 B C ATOM 16448 O GLY B 508 49.723 41.287 −9.375 1.00 54.01 B O ATOM 16450 N SER B 509 51.595 40.092 −9.038 1.00 49.18 B N ATOM 16451 CA ASER B 509 50.977 38.831 −9.421 0.50 48.36 B C ATOM 16452 CA BSER B 509 50.890 38.872 −9.440 0.50 48.06 B C ATOM 16455 CB ASER B 509 52.060 37.834 −9.871 0.50 48.19 B C ATOM 16456 CB BSER B 509 51.793 37.829 −10.102 0.50 47.86 B C ATOM 16461 OG ASER B 509 53.237 37.924 −9.070 0.50 46.36 B O ATOM 16462 OG BSER B 509 50.997 36.778 −10.655 0.50 43.78 B O ATOM 16465 C SER B 509 50.184 38.268 −8.237 1.00 47.03 B C ATOM 16466 O SER B 509 50.561 38.492 −7.083 1.00 45.61 B O ATOM 16468 N LEU B 510 49.118 37.529 −8.528 1.00 46.26 B N ATOM 16469 CA LEU B 510 48.442 36.736 −7.513 1.00 45.94 B C ATOM 16471 CB LEU B 510 47.146 36.129 −8.067 1.00 47.18 B C ATOM 16474 CG LEU B 510 46.198 37.118 −8.781 1.00 53.98 B C ATOM 16476 CD1 LEU B 510 44.910 36.427 −9.230 1.00 58.51 B C ATOM 16480 CD2 LEU B 510 45.873 38.358 −7.911 1.00 59.66 B C ATOM 16484 C LEU B 510 49.432 35.643 −7.040 1.00 43.67 B C ATOM 16485 O LEU B 510 49.486 35.316 −5.843 1.00 45.41 B O ATOM 16487 N PHE B 511 50.262 35.156 −7.969 1.00 37.67 B N ATOM 16488 CA PHE B 511 51.233 34.089 −7.707 1.00 35.65 B C ATOM 16490 CB PHE B 511 51.418 33.218 −8.967 1.00 34.37 B C ATOM 16493 CG PHE B 511 50.169 32.496 −9.394 1.00 29.50 B C ATOM 16494 CD1 PHE B 511 49.935 31.208 −8.981 1.00 27.92 B C ATOM 16496 CE1 PHE B 511 48.772 30.537 −9.360 1.00 32.35 B C ATOM 16498 CZ PHE B 511 47.838 31.173 −10.146 1.00 33.79 B C ATOM 16500 CE2 PHE B 511 48.062 32.483 −10.557 1.00 31.04 B C ATOM 16502 CD2 PHE B 511 49.213 33.128 −10.180 1.00 27.15 B C ATOM 16504 C PHE B 511 52.596 34.603 −7.235 1.00 35.79 B C ATOM 16505 O PHE B 511 52.977 35.747 −7.481 1.00 36.71 B O ATOM 16507 N ALA B 512 53.343 33.747 −6.555 1.00 36.55 B N ATOM 16508 CA ALA B 512 54.681 34.127 −6.137 1.00 37.34 B C ATOM 16510 CB ALA B 512 55.203 33.149 −5.078 1.00 36.86 B C ATOM 16514 C ALA B 512 55.593 34.159 −7.380 1.00 37.03 B C ATOM 16515 O ALA B 512 55.400 33.384 −8.315 1.00 35.37 B O ATOM 16517 N LYS B 513 56.575 35.061 −7.381 1.00 37.04 B N ATOM 16518 CA LYS B 513 57.500 35.233 −8.519 1.00 36.97 B C ATOM 16520 CB LYS B 513 58.511 36.341 −8.230 1.00 36.08 B C ATOM 16523 CG LYS B 513 57.877 37.716 −8.124 1.00 43.23 B C ATOM 16526 CD LYS B 513 58.928 38.808 −7.942 1.00 51.27 B C ATOM 16529 CE LYS B 513 58.301 40.198 −7.948 1.00 56.81 B C ATOM 16532 NZ LYS B 513 59.264 41.260 −8.368 1.00 56.22 B N ATOM 16536 C LYS B 513 58.236 33.964 −9.006 1.00 34.73 B C ATOM 16537 O LYS B 513 58.529 33.847 −10.184 1.00 35.14 B O ATOM 16539 N PRO B 514 58.539 33.019 −8.111 1.00 33.75 B N ATOM 16540 CA PRO B 514 59.171 31.801 −8.618 1.00 31.10 B C ATOM 16542 CB PRO B 514 59.475 30.993 −7.350 1.00 31.76 B C ATOM 16545 CG PRO B 514 59.565 32.013 −6.258 1.00 33.72 B C ATOM 16548 CD PRO B 514 58.575 33.088 −6.636 1.00 34.82 B C ATOM 16551 C PRO B 514 58.274 30.994 −9.531 1.00 29.47 B C ATOM 16552 O PRO B 514 58.761 30.432 −10.505 1.00 31.73 B O ATOM 16553 N PHE B 515 56.980 30.921 −9.229 1.00 27.01 B N ATOM 16554 CA PHE B 515 56.080 30.186 −10.095 1.00 24.99 B C ATOM 16556 CB PHE B 515 54.791 29.771 −9.412 1.00 22.89 B C ATOM 16559 CG PHE B 515 53.802 29.171 −10.366 1.00 25.51 B C ATOM 16560 CD1 PHE B 515 54.021 27.920 −10.902 1.00 26.17 B C ATOM 16562 CE1 PHE B 515 53.126 27.366 −11.810 1.00 26.76 B C ATOM 16564 CZ PHE B 515 52.039 28.081 −12.196 1.00 22.84 B C ATOM 16566 CE2 PHE B 515 51.816 29.356 −11.661 1.00 20.66 B C ATOM 16568 CD2 PHE B 515 52.695 29.884 −10.779 1.00 22.38 B C ATOM 16570 C PHE B 515 55.789 31.000 −11.364 1.00 24.60 B C ATOM 16571 O PHE B 515 55.775 30.452 −12.455 1.00 25.39 B O ATOM 16573 N VAL B 516 55.598 32.301 −11.241 1.00 23.02 B N ATOM 16574 CA VAL B 516 55.459 33.127 −12.435 1.00 22.33 B C ATOM 16576 CB VAL B 516 55.339 34.620 −12.126 1.00 23.22 B C ATOM 16578 CG1 VAL B 516 54.200 34.904 −11.108 1.00 23.93 B C ATOM 16582 CG2 VAL B 516 55.087 35.401 −13.412 1.00 19.34 B C ATOM 16586 C VAL B 516 56.633 32.914 −13.403 1.00 22.95 B C ATOM 16587 O VAL B 516 56.435 32.854 −14.629 1.00 23.90 B O ATOM 16589 N GLU B 517 57.834 32.776 −12.854 1.00 21.79 B N ATOM 16590 CA GLU B 517 59.049 32.572 −13.651 1.00 22.46 B C ATOM 16592 CB GLU B 517 60.298 32.804 −12.771 1.00 24.28 B C ATOM 16595 CG GLU B 517 61.663 32.717 −13.489 1.00 22.17 B C ATOM 16598 CD GLU B 517 61.902 33.823 −14.511 1.00 26.69 B C ATOM 16599 OE1 GLU B 517 61.121 34.806 −14.594 1.00 26.06 B O ATOM 16600 OE2 GLU B 517 62.892 33.702 −15.252 1.00 29.10 B O ATOM 16601 C GLU B 517 59.098 31.172 −14.273 1.00 21.73 B C ATOM 16602 O GLU B 517 59.505 31.018 −15.415 1.00 24.57 B O ATOM 16604 N THR B 518 58.717 30.151 −13.512 1.00 23.11 B N ATOM 16605 CA THR B 518 58.574 28.798 −14.050 1.00 22.81 B C ATOM 16607 CB THR B 518 58.094 27.811 −12.963 1.00 24.80 B C ATOM 16609 OG1 THR B 518 59.091 27.713 −11.936 1.00 21.57 B O ATOM 16611 CG2 THR B 518 57.851 26.398 −13.562 1.00 21.21 B C ATOM 16615 C THR B 518 57.599 28.819 −15.245 1.00 23.51 B C ATOM 16616 O THR B 518 57.850 28.237 −16.297 1.00 22.08 B O ATOM 16618 N ALA B 519 56.515 29.554 −15.105 1.00 21.37 B N ATOM 16619 CA ALA B 519 55.553 29.635 −16.188 1.00 21.72 B C ATOM 16621 CB ALA B 519 54.308 30.395 −15.737 1.00 20.07 B C ATOM 16625 C ALA B 519 56.190 30.272 −17.429 1.00 20.28 B C ATOM 16626 O ALA B 519 56.043 29.775 −18.555 1.00 19.22 B O ATOM 16628 N ILE B 520 56.935 31.350 −17.227 1.00 19.49 B N ATOM 16629 CA ILE B 520 57.552 32.014 −18.366 1.00 18.67 B C ATOM 16631 CB ILE B 520 58.218 33.311 −17.947 1.00 19.91 B C ATOM 16633 CG1 ILE B 520 57.161 34.343 −17.572 1.00 21.75 B C ATOM 16636 CD1 ILE B 520 57.701 35.559 −16.769 1.00 20.13 B C ATOM 16640 CG2 ILE B 520 59.083 33.848 −19.091 1.00 18.40 B C ATOM 16644 C ILE B 520 58.573 31.106 −19.044 1.00 18.88 B C ATOM 16645 O ILE B 520 58.740 31.162 −20.255 1.00 20.10 B O ATOM 16647 N ASN B 521 59.256 30.264 −18.268 1.00 18.94 B N ATOM 16648 CA ASN B 521 60.166 29.282 −18.848 1.00 21.21 B C ATOM 16650 CB ASN B 521 60.849 28.442 −17.757 1.00 23.50 B C ATOM 16653 CG ASN B 521 61.829 29.269 −16.895 1.00 26.39 B C ATOM 16654 OD1 ASN B 521 62.321 30.339 −17.308 1.00 20.77 B O ATOM 16655 ND2 ASN B 521 62.126 28.755 −15.700 1.00 21.46 B N ATOM 16658 C ASN B 521 59.486 28.367 −19.862 1.00 19.68 B C ATOM 16659 O ASN B 521 60.113 27.923 −20.824 1.00 22.84 B O ATOM 16661 N LEU B 522 58.208 28.091 −19.692 1.00 20.02 B N ATOM 16662 CA LEU B 522 57.544 27.288 −20.700 1.00 22.98 B C ATOM 16664 CB LEU B 522 56.093 27.008 −20.356 1.00 23.26 B C ATOM 16667 CG LEU B 522 55.375 26.269 −21.493 1.00 25.82 B C ATOM 16669 CD1 LEU B 522 55.246 24.827 −21.145 1.00 31.80 B C ATOM 16673 CD2 LEU B 522 54.016 26.847 −21.730 1.00 25.39 B C ATOM 16677 C LEU B 522 57.625 28.024 −22.040 1.00 22.13 B C ATOM 16678 O LEU B 522 57.880 27.402 −23.081 1.00 25.60 B O ATOM 16680 N ALA B 523 57.441 29.336 −22.015 1.00 17.13 B N ATOM 16681 CA ALA B 523 57.550 30.111 −23.240 1.00 19.20 B C ATOM 16683 CB ALA B 523 57.176 31.574 −23.011 1.00 18.47 B C ATOM 16687 C ALA B 523 58.936 30.029 −23.786 1.00 18.17 B C ATOM 16688 O ALA B 523 59.102 29.951 −24.972 1.00 18.29 B O ATOM 16690 N ARG B 524 59.937 30.084 −22.904 1.00 20.77 B N ATOM 16691 CA ARG B 524 61.325 30.052 −23.343 1.00 20.63 B C ATOM 16693 CB ARG B 524 62.285 30.303 −22.162 1.00 22.45 B C ATOM 16696 CG ARG B 524 62.178 31.723 −21.612 1.00 20.20 B C ATOM 16699 CD ARG B 524 63.201 32.015 −20.574 1.00 17.77 B C ATOM 16702 NE ARG B 524 63.198 33.425 −20.165 1.00 17.96 B N ATOM 16704 CZ ARG B 524 62.938 33.867 −18.944 1.00 20.16 B C ATOM 16705 NH1 ARG B 524 62.638 33.025 −17.961 1.00 24.53 B N ATOM 16708 NH2 ARG B 524 63.015 35.165 −18.692 1.00 19.14 B N ATOM 16711 C ARG B 524 61.643 28.717 −23.998 1.00 19.90 B C ATOM 16712 O ARG B 524 62.287 28.679 −25.017 1.00 19.59 B O ATOM 16714 N GLN B 525 61.179 27.632 −23.398 1.00 21.47 B N ATOM 16715 CA GLN B 525 61.387 26.314 −23.961 1.00 22.83 B C ATOM 16717 CB GLN B 525 60.887 25.221 −23.002 1.00 21.14 B C ATOM 16720 CG GLN B 525 61.193 23.820 −23.486 1.00 26.80 B C ATOM 16723 CD GLN B 525 62.683 23.560 −23.672 1.00 31.34 B C ATOM 16724 OE1 GLN B 525 63.453 23.736 −22.757 1.00 30.44 B O ATOM 16725 NE2 GLN B 525 63.075 23.120 −24.851 1.00 33.52 B N ATOM 16728 C GLN B 525 60.721 26.191 −25.332 1.00 23.13 B C ATOM 16729 O GLN B 525 61.251 25.517 −26.226 1.00 24.85 B O ATOM 16731 N SER B 526 59.586 26.856 −25.507 1.00 21.76 B N ATOM 16732 CA SER B 526 58.916 26.851 −26.788 1.00 20.34 B C ATOM 16734 CB SER B 526 57.571 27.570 −26.692 1.00 21.50 B C ATOM 16737 OG SER B 526 56.684 26.836 −25.851 1.00 24.20 B O ATOM 16739 C SER B 526 59.779 27.479 −27.833 1.00 21.36 B C ATOM 16740 O SER B 526 59.917 26.945 −28.944 1.00 20.48 B O ATOM 16742 N HIS B 527 60.376 28.622 −27.513 1.00 24.54 B N ATOM 16743 CA HIS B 527 61.245 29.288 −28.500 1.00 26.44 B C ATOM 16745 CB HIS B 527 61.754 30.633 −27.984 1.00 28.07 B C ATOM 16748 CG HIS B 527 60.721 31.719 −27.999 1.00 25.63 B C ATOM 16749 ND1 HIS B 527 60.369 32.390 −29.144 1.00 25.98 B N ATOM 16751 CE1 HIS B 527 59.433 33.278 −28.867 1.00 25.15 B C ATOM 16753 NE2 HIS B 527 59.162 33.209 −27.579 1.00 25.73 B N ATOM 16755 CD2 HIS B 527 59.961 32.245 −27.009 1.00 29.05 B C ATOM 16757 C HIS B 527 62.431 28.401 −28.858 1.00 28.50 B C ATOM 16758 O HIS B 527 62.881 28.401 −29.992 1.00 29.68 B O ATOM 16760 N CYS B 528 62.930 27.631 −27.893 1.00 28.29 B N ATOM 16761 CA CYS B 528 64.161 26.887 −28.104 1.00 32.46 B C ATOM 16763 CB CYS B 528 64.855 26.629 −26.769 1.00 32.27 B C ATOM 16766 SG CYS B 528 65.481 28.140 −26.015 1.00 29.31 B S ATOM 16768 C CYS B 528 63.912 25.578 −28.852 1.00 34.73 B C ATOM 16769 O CYS B 528 64.732 25.149 −29.651 1.00 34.26 B O ATOM 16771 N THR B 529 62.760 24.979 −28.597 1.00 37.83 B N ATOM 16772 CA THR B 529 62.332 23.742 −29.230 1.00 39.52 B C ATOM 16774 CB THR B 529 61.225 23.101 −28.376 1.00 39.20 B C ATOM 16776 OG1 THR B 529 61.806 22.677 −27.142 1.00 39.54 B O ATOM 16778 CG2 THR B 529 60.595 21.913 −29.067 1.00 38.45 B C ATOM 16782 C THR B 529 61.853 23.955 −30.672 1.00 41.75 B C ATOM 16783 O THR B 529 62.213 23.186 −31.559 1.00 41.23 B O ATOM 16785 N TYR B 530 61.062 25.001 −30.908 1.00 44.34 B N ATOM 16786 CA TYR B 530 60.511 25.268 −32.252 1.00 46.43 B C ATOM 16788 CB TYR B 530 59.041 25.705 −32.158 1.00 44.01 B C ATOM 16791 CG TYR B 530 58.222 24.607 −31.519 1.00 40.79 B C ATOM 16792 CD1 TYR B 530 57.972 23.409 −32.208 1.00 40.31 B C ATOM 16794 CE1 TYR B 530 57.243 22.359 −31.620 1.00 35.61 B C ATOM 16796 CZ TYR B 530 56.793 22.481 −30.317 1.00 34.00 B C ATOM 16797 OH TYR B 530 56.080 21.443 −29.749 1.00 38.96 B O ATOM 16799 CE2 TYR B 530 57.043 23.661 −29.596 1.00 36.22 B C ATOM 16801 CD2 TYR B 530 57.760 24.716 −30.202 1.00 32.71 B C ATOM 16803 C TYR B 530 61.389 26.233 −33.046 1.00 51.24 B C ATOM 16804 O TYR B 530 61.027 27.367 −33.322 1.00 52.48 B O ATOM 16806 N HIS B 531 62.574 25.735 −33.384 1.00 57.86 B N ATOM 16807 CA HIS B 531 63.502 26.374 −34.322 1.00 61.42 B C ATOM 16809 CB HIS B 531 64.946 26.178 −33.832 1.00 61.98 B C ATOM 16812 CG HIS B 531 65.332 24.737 −33.645 1.00 64.97 B C ATOM 16813 ND1 HIS B 531 65.394 24.135 −32.404 1.00 69.47 B N ATOM 16815 CE1 HIS B 531 65.742 22.868 −32.545 1.00 66.30 B C ATOM 16817 NE2 HIS B 531 65.906 22.625 −33.833 1.00 67.05 B N ATOM 16819 CD2 HIS B 531 65.650 23.774 −34.544 1.00 64.50 B C ATOM 16821 C HIS B 531 63.342 25.741 −35.718 1.00 63.69 B C ATOM 16822 O HIS B 531 62.596 24.762 −35.878 1.00 61.87 B O ATOM 16824 N ASN B 532 64.041 26.314 −36.709 1.00 66.30 B N ATOM 16825 CA ASN B 532 64.175 25.735 −38.056 1.00 68.40 B C ATOM 16827 CB ASN B 532 63.285 26.481 −39.070 1.00 69.94 B C ATOM 16830 CG ASN B 532 61.830 25.955 −39.112 1.00 74.76 B C ATOM 16831 OD1 ASN B 532 61.471 25.002 −38.420 1.00 78.95 B O ATOM 16832 ND2 ASN B 532 60.999 26.584 −39.941 1.00 74.30 B N ATOM 16835 C ASN B 532 65.637 25.768 −38.523 1.00 67.88 B C ATOM 16836 O ASN B 532 66.527 25.213 −37.869 1.00 66.63 B O ATOM 16838 N THR B 537 73.132 23.732 −39.964 1.00 92.67 B N ATOM 16839 CA THR B 537 72.461 22.617 −39.298 1.00 92.98 B C ATOM 16841 CB THR B 537 72.529 22.759 −37.760 1.00 93.23 B C ATOM 16843 OG1 THR B 537 73.841 23.182 −37.370 1.00 94.15 B O ATOM 16845 CG2 THR B 537 72.203 21.436 −37.073 1.00 93.23 B C ATOM 16849 C THR B 537 70.993 22.511 −39.725 1.00 92.54 B C ATOM 16850 O THR B 537 70.356 23.517 −40.039 1.00 92.39 B O ATOM 16852 N SER B 538 70.470 21.286 −39.728 1.00 92.35 B N ATOM 16853 CA SER B 538 69.082 21.011 −40.126 1.00 92.17 B C ATOM 16855 CB SER B 538 68.996 19.620 −40.773 1.00 92.20 B C ATOM 16858 OG SER B 538 69.869 18.702 −40.139 1.00 90.38 B O ATOM 16860 C SER B 538 68.120 21.123 −38.928 1.00 91.96 B C ATOM 16861 O SER B 538 68.571 21.300 −37.795 1.00 91.29 B O ATOM 16863 N PRO B 539 66.793 21.049 −39.177 1.00 92.14 B N ATOM 16864 CA PRO B 539 65.805 21.088 −38.083 1.00 91.67 B C ATOM 16866 CB PRO B 539 64.457 20.853 −38.796 1.00 92.19 B C ATOM 16869 CG PRO B 539 64.760 20.744 −40.270 1.00 93.38 B C ATOM 16872 CD PRO B 539 66.147 21.257 −40.486 1.00 92.84 B C ATOM 16875 C PRO B 539 66.045 20.051 −36.975 1.00 90.54 B C ATOM 16876 O PRO B 539 66.309 20.431 −35.832 1.00 90.62 B O ATOM 16877 N ASP B 540 65.954 18.763 −37.298 1.00 88.88 B N ATOM 16878 CA ASP B 540 66.455 17.730 −36.392 1.00 87.42 B C ATOM 16880 CB ASP B 540 66.043 16.330 −36.860 1.00 88.42 B C ATOM 16883 CG ASP B 540 64.596 15.999 −36.524 1.00 91.80 B C ATOM 16884 OD1 ASP B 540 64.173 16.250 −35.369 1.00 91.87 B O ATOM 16885 OD2 ASP B 540 63.893 15.468 −37.417 1.00 93.61 B O ATOM 16886 C ASP B 540 67.972 17.858 −36.375 1.00 84.38 B C ATOM 16887 O ASP B 540 68.541 18.552 −37.212 1.00 84.49 B O ATOM 16889 N GLU B 541 68.626 17.214 −35.416 1.00 80.82 B N ATOM 16890 CA GLU B 541 70.100 17.233 −35.315 1.00 78.19 B C ATOM 16892 CB GLU B 541 70.777 16.841 −36.642 1.00 79.32 B C ATOM 16895 CG GLU B 541 70.278 15.495 −37.189 1.00 82.73 B C ATOM 16898 CD GLU B 541 71.283 14.798 −38.084 1.00 87.94 B C ATOM 16899 OE1 GLU B 541 72.444 14.620 −37.648 1.00 90.11 B O ATOM 16900 OE2 GLU B 541 70.904 14.416 −39.216 1.00 88.49 B O ATOM 16901 C GLU B 541 70.682 18.540 −34.751 1.00 73.56 B C ATOM 16902 O GLU B 541 71.815 18.556 −34.273 1.00 73.40 B O ATOM 16904 N LEU B 542 69.927 19.632 −34.816 1.00 68.80 B N ATOM 16905 CA LEU B 542 70.113 20.705 −33.848 1.00 64.68 B C ATOM 16907 CB LEU B 542 69.553 22.044 −34.340 1.00 64.53 B C ATOM 16910 CG LEU B 542 69.909 23.238 −33.441 1.00 64.65 B C ATOM 16912 CD1 LEU B 542 69.389 24.543 −34.021 1.00 63.68 B C ATOM 16916 CD2 LEU B 542 71.420 23.328 −33.196 1.00 66.71 B C ATOM 16920 C LEU B 542 69.415 20.250 −32.563 1.00 60.16 B C ATOM 16921 O LEU B 542 69.954 20.410 −31.474 1.00 56.80 B O ATOM 16923 N THR B 543 68.239 19.641 −32.702 1.00 56.33 B N ATOM 16924 CA THR B 543 67.526 19.101 −31.546 1.00 54.58 B C ATOM 16926 CB THR B 543 66.124 18.577 −31.927 1.00 52.91 B C ATOM 16928 OG1 THR B 543 65.436 19.560 −32.707 1.00 55.01 B O ATOM 16930 CG2 THR B 543 65.311 18.285 −30.686 1.00 50.48 B C ATOM 16934 C THR B 543 68.322 17.979 −30.862 1.00 54.20 B C ATOM 16935 O THR B 543 68.443 17.967 −29.631 1.00 53.54 B O ATOM 16937 N ARG B 544 68.859 17.042 −31.650 1.00 53.07 B N ATOM 16938 CA ARG B 544 69.633 15.927 −31.084 1.00 52.95 B C ATOM 16940 CB ARG B 544 69.966 14.867 −32.153 1.00 53.76 B C ATOM 16943 CG ARG B 544 71.147 13.934 −31.807 1.00 59.59 B C ATOM 16946 CD ARG B 544 71.594 13.065 −32.998 1.00 69.45 B C ATOM 16949 NE ARG B 544 72.185 13.844 −34.099 1.00 74.98 B N ATOM 16951 CZ ARG B 544 73.462 14.230 −34.184 1.00 78.91 B C ATOM 16952 NH1 ARG B 544 74.342 13.930 −33.226 1.00 79.02 B N ATOM 16955 NH2 ARG B 544 73.866 14.932 −35.244 1.00 79.30 B N ATOM 16958 C ARG B 544 70.914 16.423 −30.396 1.00 50.09 B C ATOM 16959 O ARG B 544 71.349 15.822 −29.418 1.00 49.18 B O ATOM 16961 N LYS B 545 71.512 17.495 −30.920 1.00 47.95 B N ATOM 16962 CA LYS B 545 72.733 18.060 −30.332 1.00 49.20 B C ATOM 16964 CB LYS B 545 73.452 19.034 −31.290 1.00 50.06 B C ATOM 16967 CG LYS B 545 74.568 18.354 −32.088 1.00 58.27 B C ATOM 16970 CD LYS B 545 75.488 19.319 −32.834 1.00 65.12 B C ATOM 16973 CE LYS B 545 76.657 18.535 −33.467 1.00 70.31 B C ATOM 16976 NZ LYS B 545 77.822 19.378 −33.889 1.00 72.09 B N ATOM 16980 C LYS B 545 72.446 18.743 −29.008 1.00 46.91 B C ATOM 16981 O LYS B 545 73.292 18.769 −28.115 1.00 48.01 B O ATOM 16983 N ARG B 546 71.248 19.288 −28.873 1.00 44.64 B N ATOM 16984 CA ARG B 546 70.871 19.937 −27.632 1.00 43.28 B C ATOM 16986 CB ARG B 546 69.730 20.917 −27.871 1.00 43.53 B C ATOM 16989 CG ARG B 546 70.222 22.144 −28.634 1.00 38.72 B C ATOM 16992 CD ARG B 546 69.107 23.107 −28.977 1.00 38.25 B C ATOM 16995 NE ARG B 546 69.662 24.350 −29.501 1.00 33.40 B N ATOM 16997 CZ ARG B 546 68.947 25.364 −29.967 1.00 37.10 B C ATOM 16998 NH1 ARG B 546 67.619 25.316 −29.984 1.00 37.22 B N ATOM 17001 NH2 ARG B 546 69.578 26.440 −30.425 1.00 44.86 B N ATOM 17004 C ARG B 546 70.554 18.916 −26.552 1.00 42.26 B C ATOM 17005 O ARG B 546 70.990 19.067 −25.419 1.00 42.38 B O ATOM 17007 N VAL B 547 69.847 17.851 −26.909 1.00 41.23 B N ATOM 17008 CA VAL B 547 69.610 16.766 −25.965 1.00 40.03 B C ATOM 17010 CB VAL B 547 68.784 15.617 −26.584 1.00 41.02 B C ATOM 17012 CG1 VAL B 547 68.755 14.403 −25.652 1.00 42.61 B C ATOM 17016 CG2 VAL B 547 67.388 16.087 −26.894 1.00 35.48 B C ATOM 17020 C VAL B 547 70.949 16.242 −25.511 1.00 40.46 B C ATOM 17021 O VAL B 547 71.157 16.006 −24.324 1.00 42.73 B O ATOM 17023 N LEU B 548 71.869 16.070 −26.454 1.00 39.76 B N ATOM 17024 CA LEU B 548 73.210 15.609 −26.116 1.00 39.29 B C ATOM 17026 CB LEU B 548 74.089 15.436 −27.368 1.00 39.65 B C ATOM 17029 CG LEU B 548 74.394 13.996 −27.805 1.00 45.33 B C ATOM 17031 CD1 LEU B 548 73.140 13.267 −28.315 1.00 42.95 B C ATOM 17035 CD2 LEU B 548 75.493 13.998 −28.880 1.00 46.14 B C ATOM 17039 C LEU B 548 73.895 16.545 −25.107 1.00 37.32 B C ATOM 17040 O LEU B 548 74.409 16.086 −24.085 1.00 39.63 B O ATOM 17042 N SER B 549 73.895 17.844 −25.389 1.00 33.98 B N ATOM 17043 CA SER B 549 74.656 18.804 −24.587 1.00 32.24 B C ATOM 17045 CB SER B 549 74.859 20.074 −25.377 1.00 32.05 B C ATOM 17048 OG SER B 549 73.605 20.666 −25.577 1.00 34.09 B O ATOM 17050 C SER B 549 73.979 19.171 −23.280 1.00 30.34 B C ATOM 17051 O SER B 549 74.643 19.569 −22.328 1.00 32.04 B O ATOM 17053 N VAL B 550 72.658 19.064 −23.232 1.00 28.62 B N ATOM 17054 CA VAL B 550 71.932 19.383 −22.014 1.00 26.79 B C ATOM 17056 CB VAL B 550 70.551 19.991 −22.299 1.00 26.82 B C ATOM 17058 CG1 VAL B 550 69.800 20.186 −21.022 1.00 22.61 B C ATOM 17062 CG2 VAL B 550 70.688 21.353 −23.017 1.00 18.25 B C ATOM 17066 C VAL B 550 71.828 18.162 −21.097 1.00 29.02 B C ATOM 17067 O VAL B 550 72.112 18.264 −19.906 1.00 28.22 B O ATOM 17069 N ILE B 551 71.481 16.999 −21.652 1.00 30.73 B N ATOM 17070 CA ILE B 551 71.234 15.812 −20.832 1.00 31.06 B C ATOM 17072 CB ILE B 551 70.034 14.999 −21.334 1.00 31.51 B C ATOM 17074 CG1 ILE B 551 68.763 15.849 −21.376 1.00 30.36 B C ATOM 17077 CD1 ILE B 551 68.327 16.382 −20.035 1.00 37.56 B C ATOM 17081 CG2 ILE B 551 69.854 13.747 −20.460 1.00 29.79 B C ATOM 17085 C ILE B 551 72.395 14.829 −20.762 1.00 32.00 B C ATOM 17086 O ILE B 551 72.795 14.419 −19.678 1.00 31.17 B O ATOM 17088 N THR B 552 72.903 14.418 −21.917 1.00 34.78 B N ATOM 17089 CA THR B 552 73.696 13.200 −21.985 1.00 35.86 B C ATOM 17091 CB THR B 552 73.372 12.395 −23.266 1.00 38.74 B C ATOM 17093 OG1 THR B 552 73.836 13.097 −24.419 1.00 47.68 B O ATOM 17095 CG2 THR B 552 71.879 12.179 −23.414 1.00 30.46 B C ATOM 17099 C THR B 552 75.204 13.447 −21.829 1.00 36.32 B C ATOM 17100 O THR B 552 75.870 12.723 −21.082 1.00 37.04 B O ATOM 17102 N GLU B 553 75.753 14.469 −22.483 1.00 36.21 B N ATOM 17103 CA GLU B 553 77.217 14.663 −22.459 1.00 37.69 B C ATOM 17105 CB GLU B 553 77.744 14.854 −23.887 1.00 40.39 B C ATOM 17108 CG GLU B 553 77.790 13.550 −24.700 1.00 47.06 B C ATOM 17111 CD GLU B 553 78.488 13.705 −26.052 1.00 57.90 B C ATOM 17112 OE1 GLU B 553 79.380 12.877 −26.353 1.00 60.24 B O ATOM 17113 OE2 GLU B 553 78.145 14.649 −26.810 1.00 60.91 B O ATOM 17114 C GLU B 553 77.701 15.811 −21.563 1.00 35.39 B C ATOM 17115 O GLU B 553 77.311 16.947 −21.751 1.00 34.26 B O ATOM 17117 N PRO B 554 78.574 15.515 −20.589 1.00 36.02 B N ATOM 17118 CA PRO B 554 79.201 16.596 −19.827 1.00 34.71 B C ATOM 17120 CB PRO B 554 80.207 15.875 −18.918 1.00 34.87 B C ATOM 17123 CG PRO B 554 79.840 14.450 −18.926 1.00 37.61 B C ATOM 17126 CD PRO B 554 79.055 14.183 −20.176 1.00 37.77 B C ATOM 17129 C PRO B 554 79.954 17.593 −20.699 1.00 33.50 B C ATOM 17130 O PRO B 554 80.283 17.322 −21.858 1.00 34.84 B O ATOM 17131 N ILE B 555 80.209 18.757 −20.132 1.00 32.88 B N ATOM 17132 CA ILE B 555 81.096 19.725 −20.750 1.00 33.21 B C ATOM 17134 CB ILE B 555 80.876 21.140 −20.138 1.00 32.95 B C ATOM 17136 CG1 ILE B 555 79.500 21.664 −20.567 1.00 32.79 B C ATOM 17139 CD1 ILE B 555 79.137 23.039 −20.029 1.00 29.41 B C ATOM 17143 CG2 ILE B 555 81.957 22.100 −20.587 1.00 30.93 B C ATOM 17147 C ILE B 555 82.511 19.220 −20.501 1.00 32.07 B C ATOM 17148 O ILE B 555 82.789 18.686 −19.434 1.00 30.59 B O ATOM 17150 N LEU B 556 83.391 19.367 −21.484 1.00 32.81 B N ATOM 17151 CA LEU B 556 84.761 18.848 −21.362 1.00 34.73 B C ATOM 17153 CB LEU B 556 85.564 19.045 −22.669 1.00 34.99 B C ATOM 17156 CG LEU B 556 85.005 18.383 −23.948 1.00 39.49 B C ATOM 17158 CD1 LEU B 556 85.738 18.858 −25.230 1.00 42.15 B C ATOM 17162 CD2 LEU B 556 85.067 16.866 −23.827 1.00 40.24 B C ATOM 17166 C LEU B 556 85.454 19.540 −20.179 1.00 34.19 B C ATOM 17167 O LEU B 556 85.268 20.731 −19.971 1.00 35.29 B O ATOM 17169 N PRO B 557 86.252 18.795 −19.401 1.00 34.37 B N ATOM 17170 CA PRO B 557 86.764 19.369 −18.152 1.00 34.58 B C ATOM 17172 CB PRO B 557 87.532 18.209 −17.506 1.00 34.08 B C ATOM 17175 CG PRO B 557 87.851 17.281 −18.607 1.00 35.29 B C ATOM 17178 CD PRO B 557 86.815 17.462 −19.685 1.00 34.74 B C ATOM 17181 C PRO B 557 87.672 20.587 −18.327 1.00 34.93 B C ATOM 17182 O PRO B 557 88.198 20.847 −19.407 1.00 35.00 B O ATOM 17183 N PHE B 558 87.827 21.332 −17.245 1.00 35.20 B N ATOM 17184 CA PHE B 558 88.627 22.539 −17.251 1.00 35.65 B C ATOM 17186 CB PHE B 558 88.342 23.308 −15.962 1.00 32.90 B C ATOM 17189 CG PHE B 558 89.329 24.400 −15.656 1.00 35.99 B C ATOM 17190 CD1 PHE B 558 90.270 24.248 −14.636 1.00 38.91 B C ATOM 17192 CE1 PHE B 558 91.172 25.264 −14.339 1.00 40.56 B C ATOM 17194 CZ PHE B 558 91.140 26.448 −15.062 1.00 39.35 B C ATOM 17196 CE2 PHE B 558 90.208 26.608 −16.074 1.00 38.08 B C ATOM 17198 CD2 PHE B 558 89.311 25.589 −16.367 1.00 36.76 B C ATOM 17200 C PHE B 558 90.119 22.174 −17.388 1.00 38.66 B C ATOM 17201 O PHE B 558 90.588 21.221 −16.768 1.00 35.43 B O ATOM 17203 N GLU B 559 90.841 22.934 −18.210 1.00 43.59 B N ATOM 17204 CA GLU B 559 92.278 22.725 −18.437 1.00 49.37 B C ATOM 17206 CB GLU B 559 92.527 22.302 −19.886 1.00 50.25 B C ATOM 17209 CG GLU B 559 92.467 20.803 −20.151 1.00 55.23 B C ATOM 17212 CD GLU B 559 92.918 20.460 −21.569 1.00 62.27 B C ATOM 17213 OE1 GLU B 559 92.093 20.605 −22.507 1.00 58.80 B O ATOM 17214 OE2 GLU B 559 94.100 20.059 −21.736 1.00 59.57 B O ATOM 17215 C GLU B 559 93.083 24.001 −18.161 1.00 52.39 B C ATOM 17216 O GLU B 559 92.772 25.061 −18.707 1.00 52.68 B O ATOM 17218 N ARG B 560 94.128 23.886 −17.343 1.00 55.22 B N ATOM 17219 CA ARG B 560 95.025 25.016 −17.043 1.00 57.60 B C ATOM 17221 CB ARG B 560 95.966 24.658 −15.890 1.00 58.83 B C ATOM 17224 CG ARG B 560 95.247 24.332 −14.589 1.00 63.59 B C ATOM 17227 CD ARG B 560 95.488 25.362 −13.492 1.00 69.13 B C ATOM 17230 NE ARG B 560 94.390 25.393 −12.522 1.00 75.07 B N ATOM 17232 CZ ARG B 560 94.070 24.398 −11.686 1.00 78.47 B C ATOM 17233 NH1 ARG B 560 94.752 23.252 −11.675 1.00 78.68 B N ATOM 17236 NH2 ARG B 560 93.047 24.545 −10.847 1.00 78.46 B N ATOM 17239 C ARG B 560 95.856 25.404 −18.261 1.00 57.16 B C ATOM 17240 O ARG B 560 95.920 26.575 −18.624 1.00 57.13 B O ATOM 17242 O HOH W 1 67.396 39.491 −23.826 1.00 20.98 W O ATOM 17245 O HOH W 2 46.505 15.035 −3.469 1.00 20.88 W O ATOM 17248 O HOH W 3 36.160 7.031 −16.321 1.00 25.10 W O ATOM 17251 O HOH W 4 34.395 30.503 −35.530 1.00 17.73 W O ATOM 17254 O HOH W 5 37.638 17.344 −11.502 1.00 32.45 W O ATOM 17257 O HOH W 6 65.819 −37.512 3.562 1.00 29.91 W O ATOM 17260 O HOH W 7 56.866 −34.130 −11.051 1.00 31.56 W O ATOM 17263 O HOH W 8 43.972 −6.315 −15.500 1.00 23.40 W O ATOM 17266 O HOH W 9 60.228 −40.852 2.964 1.00 21.46 W O ATOM 17269 O HOH W 10 43.012 23.511 −17.712 1.00 41.96 W O ATOM 17272 O HOH W 11 38.135 14.576 −14.888 1.00 28.05 W O ATOM 17275 O HOH W 12 57.728 −35.432 5.083 1.00 24.61 W O ATOM 17278 O HOH W 13 57.235 −51.809 −9.446 1.00 34.71 W O ATOM 17281 O HOH W 14 66.193 38.695 −7.571 1.00 26.05 W O ATOM 17284 O HOH W 15 36.482 −23.763 3.380 1.00 35.70 W O ATOM 17287 O HOH W 16 63.221 −40.097 3.528 1.00 27.60 W O ATOM 17290 O HOH W 17 73.515 25.429 6.453 1.00 49.84 W O ATOM 17293 O HOH W 18 53.192 45.369 −20.010 1.00 31.15 W O ATOM 17296 O HOH W 19 77.678 42.352 1.054 1.00 32.86 W O ATOM 17299 O HOH W 20 48.264 −34.170 15.244 1.00 46.42 W O ATOM 17302 O HOH W 21 39.547 35.857 −35.345 1.00 19.86 W O ATOM 17305 O HOH W 22 35.404 −1.739 −16.317 1.00 27.73 W O ATOM 17308 O HOH W 23 62.314 8.273 −25.549 1.00 44.96 W O ATOM 17311 O HOH W 24 42.306 22.146 −12.509 1.00 21.07 W O ATOM 17314 O HOH W 25 41.363 11.085 −35.066 1.00 18.32 W O ATOM 17317 O HOH W 26 46.155 −26.355 −2.836 1.00 27.33 W O ATOM 17320 O HOH W 27 73.732 29.702 −30.702 1.00 33.09 W O ATOM 17323 O HOH W 28 55.875 −54.406 1.824 1.00 32.16 W O ATOM 17326 O HOH W 29 55.002 28.302 −1.446 1.00 42.39 W O ATOM 17329 O HOH W 30 45.510 −23.435 −12.887 1.00 39.50 W O ATOM 17332 O HOH W 31 53.296 48.691 −18.974 1.00 46.53 W O ATOM 17335 O HOH W 32 65.749 −34.978 8.760 1.00 23.25 W O ATOM 17338 O HOH W 33 41.864 −40.579 7.567 1.00 27.81 W O ATOM 17341 O HOH W 34 62.501 38.943 −10.518 1.00 24.84 W O ATOM 17344 O HOH W 35 62.874 −31.234 17.475 1.00 40.25 W O ATOM 17347 O HOH W 36 72.629 −36.786 2.592 1.00 26.17 W O ATOM 17350 O HOH W 37 33.607 7.834 −9.701 1.00 45.87 W O ATOM 17353 O HOH W 38 77.284 −36.310 −9.186 1.00 41.42 W O ATOM 17356 O HOH W 39 77.331 43.278 −25.049 1.00 30.11 W O ATOM 17359 O HOH W 40 39.966 −6.135 −21.236 1.00 39.64 W O ATOM 17362 O HOH W 41 53.845 −3.289 6.774 1.00 27.25 W O ATOM 17365 O HOH W 42 39.457 24.448 −15.702 1.00 31.86 W O ATOM 17368 O HOH W 43 50.941 −47.129 15.355 1.00 37.33 W O ATOM 17371 O HOH W 44 31.147 15.698 −26.421 1.00 31.90 W O ATOM 17374 O HOH W 45 75.880 39.481 −22.456 1.00 24.94 W O ATOM 17377 O HOH W 46 54.871 30.920 −42.208 1.00 31.91 W O ATOM 17380 O HOH W 47 65.261 −50.315 5.447 1.00 32.59 W O ATOM 17383 O HOH W 48 71.408 −9.056 −6.457 1.00 27.35 W O ATOM 17386 O HOH W 49 68.507 −42.622 −19.180 1.00 39.04 W O ATOM 17389 O HOH W 50 40.635 −32.994 −1.450 1.00 29.96 W O ATOM 17392 O HOH W 51 43.834 39.340 −19.280 1.00 44.69 W O ATOM 17395 O HOH W 52 49.324 −10.510 −8.611 1.00 22.83 W O ATOM 17398 O HOH W 53 73.154 −41.586 −3.585 1.00 28.18 W O ATOM 17401 O HOH W 54 74.167 −32.081 10.431 1.00 38.80 W O ATOM 17404 O HOH W 55 32.208 −24.041 27.564 1.00 36.12 W O ATOM 17407 O HOH W 56 81.358 51.348 −21.846 1.00 36.22 W O ATOM 17410 O HOH W 57 28.049 −9.147 14.182 1.00 28.08 W O ATOM 17413 O HOH W 58 53.295 −33.548 −8.420 1.00 32.02 W O ATOM 17416 O HOH W 59 33.141 −27.930 14.065 1.00 49.40 W O ATOM 17419 O HOH W 60 73.963 42.850 −22.320 1.00 27.05 W O ATOM 17422 O HOH W 61 57.737 18.482 −4.811 1.00 40.88 W O ATOM 17425 O HOH W 62 41.825 42.820 −42.173 1.00 33.38 W O ATOM 17428 O HOH W 63 32.765 16.578 −23.918 1.00 31.22 W O ATOM 17431 O HOH W 64 37.857 13.924 −10.555 1.00 34.26 W O ATOM 17434 O HOH W 65 89.849 19.986 −14.523 1.00 30.80 W O ATOM 17437 O HOH W 66 28.309 −3.232 7.889 1.00 33.97 W O ATOM 17440 O HOH W 67 81.027 23.484 4.883 1.00 29.67 W O ATOM 17443 O HOH W 68 92.000 34.104 −14.235 1.00 25.36 W O ATOM 17446 O HOH W 69 33.611 −22.981 9.544 1.00 26.38 W O ATOM 17449 O HOH W 70 69.544 29.746 3.258 1.00 45.00 W O ATOM 17452 O HOH W 71 33.580 19.200 −28.527 1.00 28.54 W O ATOM 17455 O HOH W 72 60.973 −6.895 13.133 1.00 51.02 W O ATOM 17458 O HOH W 73 63.662 −53.195 6.160 1.00 31.10 W O ATOM 17461 O HOH W 74 40.501 13.400 9.740 1.00 29.39 W O ATOM 17464 O HOH W 75 31.268 −0.700 −16.248 1.00 38.68 W O ATOM 17467 O HOH W 76 64.405 12.253 −9.311 1.00 32.15 W O ATOM 17470 O HOH W 77 51.823 −41.573 −13.076 1.00 38.60 W O ATOM 17473 O HOH W 78 52.094 −48.948 −6.963 1.00 36.07 W O ATOM 17476 O HOH W 79 65.280 −37.041 19.710 1.00 36.79 W O ATOM 17479 O HOH W 80 73.752 −42.738 −1.116 1.00 42.80 W O ATOM 17482 O HOH W 81 33.127 5.296 2.323 1.00 34.50 W O ATOM 17485 O HOH W 82 52.917 19.244 −39.930 1.00 38.53 W O ATOM 17488 O HOH W 83 31.947 −16.214 −2.242 1.00 42.38 W O ATOM 17491 O HOH W 84 44.466 34.961 −48.175 1.00 39.18 W O ATOM 17494 O HOH W 85 73.801 10.513 −12.397 1.00 34.17 W O ATOM 17497 O HOH W 86 56.162 −30.900 13.891 1.00 36.49 W O ATOM 17500 O HOH W 87 58.302 40.830 −34.099 1.00 38.00 W O ATOM 17503 O HOH W 88 67.361 57.337 −12.595 1.00 35.90 W O ATOM 17506 O HOH W 89 36.407 16.844 −14.535 1.00 34.76 W O ATOM 17509 O HOH W 90 36.526 −2.835 −11.577 1.00 29.09 W O ATOM 17512 O HOH W 91 63.568 38.471 −8.120 1.00 33.00 W O ATOM 17515 O HOH W 92 31.876 −24.706 −14.685 1.00 47.13 W O ATOM 17518 O HOH W 93 57.122 46.180 −41.231 1.00 38.56 W O ATOM 17521 O HOH W 94 40.989 25.119 −38.866 1.00 34.26 W O ATOM 17524 O HOH W 95 70.573 35.539 −11.174 1.00 34.26 W O ATOM 17527 O HOH W 96 67.166 −18.296 −0.056 1.00 21.97 W O ATOM 17530 O HOH W 97 68.329 −19.165 −2.481 1.00 27.46 W O ATOM 17533 O HOH W 98 46.453 −46.459 −0.096 1.00 23.67 W O ATOM 17536 O HOH W 99 64.859 −27.821 −0.476 1.00 23.74 W O ATOM 17539 O HOH W 100 49.889 −41.983 −4.752 1.00 19.81 W O ATOM 17542 O HOH W 101 63.104 −35.094 −0.981 1.00 21.48 W O ATOM 17545 O HOH W 102 46.208 22.160 −21.251 1.00 17.27 W O ATOM 17548 O HOH W 103 44.240 21.517 −19.373 1.00 18.97 W O ATOM 17551 O HOH W 104 60.940 −21.568 −0.115 1.00 20.52 W O ATOM 17554 O HOH W 105 58.540 −23.194 −0.426 1.00 28.03 W O ATOM 17557 O HOH W 106 52.842 −31.073 −2.319 1.00 18.19 W O ATOM 17560 O HOH W 107 50.708 −32.784 −1.585 1.00 21.26 W O ATOM 17563 O HOH W 108 42.573 24.337 −31.730 1.00 23.68 W O ATOM 17566 O HOH W 109 41.632 −13.280 2.319 1.00 19.40 W O ATOM 17569 O HOH W 110 40.075 −12.128 0.609 1.00 22.13 W O ATOM 17572 O HOH W 111 61.623 26.993 −12.882 1.00 31.00 W O ATOM 17575 O HOH W 112 53.819 33.804 −16.115 1.00 25.71 W O ATOM 17578 O HOH W 113 45.232 4.296 −9.419 1.00 19.63 W O ATOM 17581 O HOH W 114 67.086 25.456 −18.731 1.00 20.32 W O ATOM 17584 O HOH W 115 69.127 −23.507 −5.191 1.00 19.05 W O ATOM 17587 O HOH W 116 40.100 −27.766 7.117 1.00 26.86 W O ATOM 17590 O HOH W 117 41.450 14.502 −35.661 1.00 21.87 W O ATOM 17593 O HOH W 118 39.215 14.175 −36.764 1.00 21.90 W O ATOM 17596 O HOH W 119 61.445 47.858 −13.974 1.00 30.41 W O ATOM 17599 O HOH W 120 42.487 −37.324 1.207 1.00 19.42 W O ATOM 17602 O HOH W 121 41.098 −41.117 0.324 1.00 20.14 W O ATOM 17605 O HOH W 122 58.612 −35.406 −0.839 1.00 24.21 W O ATOM 17608 O HOH W 123 50.164 1.626 −14.069 1.00 17.73 W O ATOM 17611 O HOH W 124 50.992 −34.804 12.341 1.00 30.50 W O ATOM 17614 O HOH W 125 70.666 34.211 −26.020 1.00 27.41 W O ATOM 17617 O HOH W 126 57.737 −13.710 −12.328 1.00 35.35 W O ATOM 17620 O HOH W 127 75.308 25.160 −13.718 1.00 16.25 W O ATOM 17623 O HOH W 128 60.917 −29.336 2.205 1.00 27.11 W O ATOM 17626 O HOH W 129 37.974 −12.318 −6.397 1.00 29.33 W O ATOM 17629 O HOH W 130 63.665 −29.882 −4.118 1.00 31.17 W O ATOM 17632 O HOH W 131 61.715 −32.330 −8.029 1.00 41.88 W O ATOM 17635 O HOH W 132 72.648 30.403 −18.375 1.00 23.01 W O ATOM 17638 O HOH W 133 53.042 17.634 −10.102 1.00 23.18 W O ATOM 17641 O HOH W 134 60.025 38.653 −17.369 1.00 20.09 W O ATOM 17644 O HOH W 135 61.712 36.617 −16.767 1.00 26.79 W O ATOM 17647 O HOH W 136 61.300 41.278 −13.860 1.00 21.09 W O ATOM 17650 O HOH W 137 62.073 −31.149 7.450 1.00 33.22 W O ATOM 17653 O HOH W 138 55.630 −21.810 −5.863 1.00 43.72 W O ATOM 17656 O HOH W 139 42.191 33.282 −26.587 1.00 21.30 W O ATOM 17659 O HOH W 140 46.789 38.171 −22.658 1.00 44.17 W O ATOM 17662 O HOH W 141 32.524 32.302 −32.556 1.00 27.94 W O ATOM 17665 O HOH W 142 83.918 41.902 −15.045 1.00 20.74 W O ATOM 17668 O HOH W 143 57.939 −30.258 0.884 1.00 32.72 W O ATOM 17671 O HOH W 144 48.703 −35.022 7.181 1.00 37.63 W O ATOM 17674 O HOH W 145 66.347 31.640 −19.130 1.00 30.26 W O ATOM 17677 O HOH W 146 64.998 30.057 −17.211 1.00 22.53 W O ATOM 17680 O HOH W 147 65.134 27.653 −18.405 1.00 22.78 W O ATOM 17683 O HOH W 148 66.094 38.403 −18.347 1.00 23.57 W O ATOM 17686 O HOH W 149 35.459 0.990 18.585 1.00 22.46 W O ATOM 17689 O HOH W 150 71.717 −45.326 −18.716 1.00 33.34 W O ATOM 17692 O HOH W 151 50.671 5.704 −4.812 1.00 26.81 W O ATOM 17695 O HOH W 152 61.207 −27.443 −25.202 1.00 50.62 W O ATOM 17698 O HOH W 153 74.197 −28.017 −17.761 1.00 32.53 W O ATOM 17701 O HOH W 154 39.585 −1.129 16.289 1.00 21.92 W O ATOM 17704 O HOH W 155 62.622 −29.524 −0.090 1.00 32.78 W O ATOM 17707 O HOH W 156 70.598 −25.384 −3.982 1.00 23.20 W O ATOM 17710 O HOH W 157 56.563 −33.832 −0.616 1.00 27.25 W O ATOM 17713 O HOH W 158 51.474 −35.440 −5.147 1.00 26.23 W O ATOM 17716 O HOH W 159 49.890 −35.190 −2.859 1.00 23.25 W O ATOM 17719 O HOH W 160 53.387 −33.463 −5.052 1.00 31.52 W O ATOM 17722 O HOH W 161 64.357 −36.964 7.375 1.00 28.26 W O ATOM 17725 O HOH W 162 64.771 −39.173 5.737 1.00 31.93 W O ATOM 17728 O HOH W 163 40.629 −47.274 5.327 1.00 20.11 W O ATOM 17731 O HOH W 164 49.479 −36.987 8.266 1.00 38.74 W O ATOM 17734 O HOH W 165 50.017 −31.400 12.975 1.00 31.54 W O ATOM 17737 O HOH W 166 72.235 −28.166 9.021 1.00 33.15 W O ATOM 17740 O HOH W 167 75.744 −38.559 −1.129 1.00 34.88 W O ATOM 17743 O HOH W 168 60.678 −3.886 6.560 1.00 43.68 W O ATOM 17746 O HOH W 169 54.251 −10.331 7.262 1.00 44.60 W O ATOM 17749 O HOH W 170 55.713 −14.623 −10.880 1.00 27.94 W O ATOM 17752 O HOH W 171 34.828 7.528 15.394 1.00 23.35 W O ATOM 17755 O HOH W 172 30.137 −4.012 5.182 1.00 32.68 W O ATOM 17758 O HOH W 173 38.389 −13.593 −1.858 1.00 55.11 W O ATOM 17761 O HOH W 174 36.850 −1.221 17.151 1.00 23.53 W O ATOM 17764 O HOH W 175 38.073 −28.751 3.642 1.00 47.59 W O ATOM 17767 O HOH W 176 36.616 −30.178 2.331 1.00 40.67 W O ATOM 17770 O HOH W 177 42.744 −37.262 9.632 1.00 29.50 W O ATOM 17773 O HOH W 178 42.616 −35.921 11.849 1.00 42.95 W O ATOM 17776 O HOH W 179 57.767 −25.689 −1.640 1.00 31.54 W O ATOM 17779 O HOH W 180 78.821 47.464 −4.619 1.00 41.91 W O ATOM 17782 O HOH W 181 72.583 36.467 −26.619 1.00 34.41 W O ATOM 17785 O HOH W 182 58.768 41.958 −26.296 1.00 36.05 W O ATOM 17788 O HOH W 183 58.524 37.308 −31.915 1.00 27.65 W O ATOM 17791 O HOH W 184 59.204 34.222 −32.284 1.00 31.17 W O ATOM 17794 O HOH W 185 67.396 24.341 −21.206 1.00 28.49 W O ATOM 17797 O HOH W 186 73.538 21.133 −16.293 1.00 20.45 W O ATOM 17800 O HOH W 187 85.397 37.797 −17.665 1.00 32.53 W O ATOM 17803 O HOH W 188 63.942 25.997 −4.112 1.00 54.26 W O ATOM 17806 O HOH W 189 53.679 16.888 −7.621 1.00 33.46 W O ATOM 17809 O HOH W 190 34.187 3.648 −33.715 1.00 31.20 W O ATOM 17812 O HOH W 191 38.654 −3.056 −28.664 1.00 31.71 W O ATOM 17815 O HOH W 192 36.665 19.812 −19.436 1.00 30.48 W O ATOM 17818 O HOH W 193 38.939 22.647 −22.845 1.00 25.48 W O ATOM 17821 O HOH W 194 33.628 27.331 −38.304 1.00 38.64 W O ATOM 17824 O HOH W 195 41.094 33.581 −28.770 1.00 21.68 W O ATOM 17827 O HOH W 196 37.378 31.618 −27.424 1.00 46.50 W O ATOM 17830 O HOH W 197 37.702 28.581 −29.110 1.00 25.65 W O ATOM 17833 O HOH W 198 60.016 20.154 −7.770 1.00 31.81 W O ATOM 17836 O HOH W 199 44.586 28.481 1.221 1.00 33.43 W O ATOM 17839 O HOH W 200 38.150 20.885 −9.839 1.00 37.13 W O ATOM 17842 O HOH W 201 44.203 35.043 −19.031 1.00 37.68 W O ATOM 17845 O HOH W 202 43.620 33.989 −22.475 1.00 31.80 W O ATOM 17848 O HOH W 203 56.689 23.953 −42.205 1.00 38.64 W O ATOM 17851 O HOH W 204 59.706 41.117 −16.030 1.00 22.92 W O ATOM 17854 O HOH W 205 55.135 39.948 −8.848 1.00 53.09 W O END

Example 5 Engineering Populus alba Isoprene Synthase for Improved Activity

This example described methods to identify P. alba isoprene synthase (IspS) variants with increased activity, sites for protein engineering studies were chosen based on the crystal structure of the enzyme. Twenty-five site evaluation libraries (SELs) were analyzed for specific activity, and subsequently ranked according to their performance relative to controls.

I. SEL Plasmid Backbone

The plasmid backbone used to generate the 25 SELs was constructed by QuikChange (Stratagene) PCR on the template pDu39 (see U.S. patent application Ser. No. 12/429,143). The PCR reaction mixtures were as follows: 1 μl pDu39, 5 μl 10× PfuUltra HF buffer, 1 μl dNTPs, 1 μl (50 μM) MEA Hairpin Disrupt (pET) F (Table 4-1), 1 μl (50 μM) MEA Hairpin Disrupt (pET) R (Table 5-1), 2 μl DMSO, 39 μl diH₂O, 1 μl PfuUltra HF Polymerase (Stratagene). The PCR Cycling Parameters for QuikChange were as follows: 1. 95° C. 1 min, 2. 95° C. 50 sec, 3. 60° C. 50 sec, 4. 68° C. 7 min, 5. Repeat steps 2-4 for 18 cycles, 6. 68° C. 7 min. The PCR product was treated with 1 μl DpnI (Roche) for 3 hours, and then 1 μl of the entire reaction was transformed into chemically competent E. coli Top10 cells (Invitrogen), recovered, and plated according to the manufacturer's recommendations. The next day, positive colonies were chosen for growth, plasmid purification (Qiagen) and sequencing (Quintara Biosciences). Plasmids which harbored the correct base changes introduced using the Quikchange Site-Directed Mutagenesis Kit (Stratagene) were selected for sequencing of the entire open reading frame to confirm the integrity of the coding sequence. One of these plasmids, pCL201 (see FIGS. 39-41), was selected as the backbone for construction of the 25 SELs (Verdezyne).

TABLE 5-1 Primer sequences MEA Hairpin Disrupt ggagatatacatatggaagcacgtcgc (pET) F tctgcgaactacgaacctaa (SEQ ID NO: 46) MMEA Hairpin Disrupt ttaggttcgtagttcgcagagcgacgtg (pET) R cttccatatgtatatctcc (SEQ ID NO: 47) T7 Forward taatacgactcactataggg (SEQ ID NO: 48) T7 Reverse gctagttattgctcagcgg (SEQ ID NO: 49) 1000 gcactgtctttccgtctgctgc (SEQ ID NO: 50) QB1493 cttcggcaacgcatggaaat (SEQ ID NO: 51) A-rev ctcgtacaggctcaggatag (SEQ ID NO: 52) A-rev2 ttacgtcccaacgctcaact (SEQ ID NO: 53) II. 25 Site Evaluation Libraries

Sites for the 25 SELs were chosen based upon the crystal structure of P. alba IspS (Example 4). Table 5-2 lists all sites and a description of their putative role within the enzyme. Alterations in surface hydrophobic residues may affect protein folding, solubility or activity. Sites in the “hinge region” are located in a helix that spans the N-terminus and the C-terminus, and may dictate how those two halves of the enzyme interact with each other. Sites in the “negatively charged area” are in a region of the protein with a high density of acidic residues, which may somehow regulate activity. Sites within the “flexible loops” are proximal to the active site, and may affect substrate binding, as would sites that are directly within the active site (see Table 5-2). FIG. 42 shows the structure of an IspS dimer, and FIG. 43 shows a monomer. FIG. 44 shows all 25 sites chosen for SELs in stick diagram on the ribbon diagram backbone of the IspS monomer. SELs were generated in the pCL201 plasmid backbone. Plasmids harboring IspS variants were transformed into BL21 DE3 pLysS (Invitrogen) and delivered as glycerol stocks for subsequent growth and screening. FIG. 45 shows the layout of a typical 96-well plate containing 4 complete libraries to be screened for isoprene production and protein concentration. In some cases, where a specific substitution could not be isolated, a the wild type codon was substituted instead.

TABLE 5-2 Sites for SEL Description Sites for SEL Surface hydrophobic residues I28, V30, L130, G153, V299, L303, L469, L494 Hinge region R198, I229, L260 Negatively charged area D311, D323 Flexible loops A443, A453, N454, H515, A519, E525 Active site F388, N438, E451 Miscellaneous D345, R528, T536 III. DMAPP Assay

A) Growth and Induction

1. Prepared Patch Plates from Glycerol Stock Plates. Using a V&S 96 pin Replication Tool, cultures were patched onto a LB Agar 35 CMP/50 Kan large patch plates from overnight glycerol stock plates. Plates were incubated at 30° C. overnight for 20 to 24 hr. Cultures can be stored at 4° C. for up to a week.

2. Prepared Overnight Growth Plates. 500 mL of LB 35 CMP/50 Kan media were prepared. 300 μL/well of LB 35 CMP/50 Kan media were dispensed into deep 96 well plates (VWR). Using a V&S Replication Tool, the patch inoculum was transferred into deep 96 well plate by touching the tool pins to respective patch and using a circular motion to coat the pins with inoculum. The media was inoculated by dipping the tool then shaking the pin within the well. The overnight growth plates were sealed using a Breathe-Easier Sealing Membrane (Diversified Biotech). The plates were incubated in a Vertiga Shaking Incubator at 30° C. with shaking at 800 rpm overnight for 16 to 18 hr.

3. Prepared Day Growth Plate. Deep 96 well plates were prepared by dispensing 588 μL/well of LB 35 CMP/50 Kan media. Overnight growth plates were removed from the incubator. Overnight cultures were diluted 50-fold and 12 μL of overnight culture were transferred to day growth plates containing 588 μL/well of LB media containing antibiotics. Overnight growth plates were sealed with new Breathe-Easier Sealing Membranes. Cultures were incubated at 30° C. and 800 rpm for 2.5 hr. Frozen 12 mM IPTG (Sigma) vials were removed from −20° C. and placed in a hood to thaw.

4. OD₆₀₀ Plate Read of Overnight, Induction, and Harvest. 150 μL 1×PBS were dispensed into 96 well Costar Read Plates (#9017). 50 μL of culture samples were transferred to Read Plates. The OD₆₀₀ reading was recorded using a Spectramax Plate Reader (Molecular Devices).

5. Induction. Electronic multi-channel pipettors were prepared to dispense 4×20 μL/well of IPTG (if 4× replicates). The multi-dispense option in the electronic pipettor was adjusted if more replicates was necessary. Thawed 12 mM IPTG was poured into 50 mL or 100 mL sterile reservoirs. 20 μL/well of IPTG into each 600 μL/well culture. Overnight growth plates were resealed. Cultures were incubated at 30° C. and 800 rpm for 4 hr. OD₆₀₀ readings of plates were recorded according instructions above.

6. Harvest. 400 μL of induced culture were transferred to 800 μL Grenier storage plates. Plates were centrifuged at 3300 rpm for 20 min at 2° to 8° C. in a low speed benchtop centrifuge. Supernatants were discarded, pellets should stay in the conical bottom well. Residual supernatants were slapped out onto a paper towel on the benchtop. Plates were sealed with an aluminum foil membrane (Beckman-Coulter). Plates were covered with a plastic plate lid if available. Storage plates were labeled accordingly and stored frozen at −80° C.

B) DMAPP Assay

Plates containing induced cell pellets were removed from the −80° C. freezer and allowed to thaw on the benchtop for 30 minutes prior to lysis. 200 μl of lysis buffer (50 mM Tris pH 8, 25 mM MgCl₂, 74 μg/ml DNase I, 250 U/ml lysozyme, 0.1% Tween 20, 0.5 mM PMSF) was added to each pellet, and plates were incubated on an Eppendorf Thermomixer at 25° C. for 30 minutes at 1200 rpm. After lysis, plates were centrifuged at 3450 rpm for 15 minutes at 4° C. Supernatants were then removed and diluted 10-fold prior to DMAPP assay. 80 μl of the diluted supernatant was added to 20 μl of the DMAPP working stock (20 mM DMAPP in 0.1 M Phosphate Buffer pH 8.2, DMAPP triammonium salt, Cayman chemicals) in a Zinsser glass block. Blocks were then sealed with aluminum sealing membranes, and incubated in Thermomixers at 25° C. for 30 minutes at 450 rpm. Reactions were stopped by incubating blocks on Thermomixers at 70° C. for 12 minutes at 450 rpm. GC-MS was then used for headspace measurements to calculate the amount of isoprene produced by each lysates.

Headspace Assay. A sample of 200 μl of the desired culture is inoculated into 2 ml CTC headspace vials (Agilent vial Catalog No. 5188 2753, and cap Catalog No. 5188 2759). The cap was screwed on tightly and the vials were incubated at 37° C. with shaking at 250 rpm. After 30 minutes the vials were removed from the incubator and cooled briefly with ambient tap water. The vials were placed into the CombiPal Headspace auto sampler for analysis by GC-MS. The analysis was performed using an Agilent 6890 GC/MS system interfaced with a CTC Analytics CombiPAL autosampler operating in headspace mode. An Agilent HP-5MS GC/MS column (30 m×0.25 mm; 0.25 μm film thickness) was used for separation of analytes. The sampler was set up to inject 500 μL of headspace gas. The GC/MS method utilized helium as the carrier gas at a flow of 1 ml/min. The injection port was held at 250° C. with a split ratio of 50:1. The oven temperature was held at 37° C. for the 2 min duration of the analysis. The Agilent 5793N mass selective detector was run in single ion monitoring (SIM) mode on m/z 67. The detector was switched off from 1.4 to 1.7 minutes to allow the elution of permanent gases. Under these conditions isoprene (2-methyl-1,3-butadiene) was observed to elute at 1.78 minutes. A calibration table was used to quantify the absolute amount of isoprene and was found to be linear from 1 μg/L to 200 μg/L. The limit of detection was estimated to be 50-100 μg/L using this method.

IV. Rapid ELISA Protocol Using 96-Well PVDF Filter Plates:

Frozen liquid alkaline phosphatase substrate was removed from the freezer and allowed to come to room temperature. PVDF plates (Millipore, Whatman) are pre-wetted by adding 50 μl 50% MeOH per well. Calibration curve samples are prepared in blue PCR plates (Bio-Rad plates are good for low volumes). Normally, 10 μl of 100 ug/ml standard was added to 90 μl TBSD for 1:10 dilution, followed by 1:2 serial dilutions in TBSD. TBSD was 50 mM Tris pH 8, 150 mM NaCl, 0.1% Na deoxycholate (from a 10% w/v solution in 50% EtOH stock), 0.05% Na azide). Samples were prepared in one or more dilutions in blue PCR plate (or suitable low volume plate). 100 μl H₂O was added to PVDF plate and removed by vacuum and washed with H₂O (2×100 μl). A microtiter plate vacuum manifold, set for 10-15 in. Hg vacuum, was used. 50 μl TBSD was added to PVDF plate. Calibrators and samples were added to the PVDF plate, usually in duplicate, allowed to sit 5 min. or longer, and then removed by vacuum. 50 μl blocking buffer (TBST+1% BSA; TBST was 50 mM Tris pH 8, 150 mM NaCl, 0.1% Tween 80, 0.05% Na azide) was added to the PVDF plate and let sit 15 min. or longer. 1° antibody was prepared in blocking buffer (about 1:2000 dilution, depending on target). 2° antibody in blocking buffer (normally goat anti-rabbit alkaline phosphatase conjugate, 1:2000 dilution). PVDF plate was vacuumed and 50 μl 1° antibody was added. The plate was allowed to sit for 5 min. or longer and then vacuumed. The plate was washed 4 times with 200 μl TBST. The 2° antibody was added at a 1:2000 dilution and allowed to sit for 5 min. or longer and then the 2° antibody was removed by vacuum. The plate was washed 4 times with 200 μl TBST. 120 μl of Alkaline phosphatase substrate solution, p-nitrophenyl phosphate liquid substrate (Sigma #N7653), was added to the plate. Color development was monitored and stop reaction when appropriate, normally 10-30 min. The color reaction was stopped by transferring 80 μl to a clear microtiter plate, or by adding 50 μl 3N NaOH followed by transferring 130 μl to clear microtiter plate. The absorbance of each reaction was read in plate reader at 405 nm. Data was exported as a .txt file and imported into an Excel spreadsheet. The average of calibrator replicates was calculated and standard curves were plotted as A₄₀₅ (x-axis) and μg/ml (y-axis). Best curve fit were determined using linear, power, or exponential algorithms. For best results, only the calibrator range that corresponded to the sample range was used. Because Excel may have difficulty with the entire calibrator range, multiple smaller ranges may be used. Best curve fit equations were used to calculate concentrations of samples. Optimum antibody concentrations were determined empirically. Usual concentrations ran between 1:1000 and 1:8000, but results may vary with target immunogenicity, animal response, and assay concentration range.

V. Results

Site evaluation libraries were screened for specific activity. The performance of variant molecules was determined by activity on a substrate dimethylallyldiphosphate (DMAPP) per unit weight of the molecule (see above). Variant molecules were ranked relative to the parental molecule. The performance index was calculated as activity per unit weight relative the parental molecule. The parental molecule had a performance index of one, by definition. Activity of the parental molecule was calculated as the average of 22-24 assays of the parental molecule. A performance index greater than one indicates an improved molecule.

The positions of some high performing variants mapped onto the crystal structure of P. alba IspS are shown in FIGS. 46 through 50. These include but are not limited to sites 469 and 494 (surface hydrophobic, see Table 5-2 and FIGS. 46), 443, 453, and 515 (flexible loops, see Table 5-2 and FIG. 47), 323 (negatively charged area, see Table 5-2 and FIG. 48), 229 (hinge region, see Table 5-2 and FIGS. 49), and 536 (miscellaneous, see Table 5-2 and FIG. 50). The specific amino acid changes at these sites include but are not limited to I229V, I229L, D323M, A443S, A453I, A453L, A453N, L469A, L494C, L494G, L494I, L494P, L494V, H515M, T536F, T536Y, T536V, T536I, T536M, T536H, T536C, and T536L. Table 5-3 shows a list of variants at sites based on performance index.

Sites 198, 438, and 451 have a low tolerance for substitution as evidenced by all variants displaying reduced specific activity. Similarly, site 528 shows a low tolerance for substitution, with only a conservative variant lysine residue producing activity similar to the parental arginine.

TABLE 5-3 Performance indices of variants performance performance site variant index site variant index I28 W 1.53 V30 K 1.06 I28 T 1.25 V30 I 0.90 I28 R 1.05 V30 E 0.86 I28 Y 1.02 V30 W 0.85 I28 G 0.93 V30 Y 0.81 I28 F 0.84 V30 G 0.80 I28 S 0.75 V30 F 0.76 I28 N 0.73 V30 Q 0.72 I28 V 0.72 V30 C 0.72 I28 M 0.72 V30 P 0.67 I28 P 0.71 V30 R 0.65 I28 A 0.71 V30 L 0.65 I28 L 0.68 V30 D 0.64 I28 E 0.59 V30 T 0.61 I28 D 0.57 V30 A 0.60 I28 C 0.53 V30 S 0.60 V30 M 0.57 V30 N 0.53 performance performance site variant index site variant index L130 W 1.54 G153 K 1.19 L130 K 1.54 G153 H 1.18 L130 S 1.48 G153 L 1.16 L130 Y 1.37 G153 W 1.08 L130 R 1.30 G153 Y 0.99 L130 V 1.22 G153 N 0.91 L130 I 1.20 G153 R 0.90 L130 E 1.06 G153 S 0.80 L130 D 1.04 G153 Q 0.79 L130 Q 0.96 G153 A 0.75 L130 G 0.95 G153 T 0.74 L130 A 0.93 G153 P 0.72 L130 M 0.87 G153 D 0.72 L130 C 0.81 G153 C 0.69 L130 P 0.43 G153 M 0.68 G153 V 0.64 performance performance site variant index site variant index I229 V 4.41 L260 N 1.12 I229 L 3.77 L260 M 1.10 I229 C 1.35 L260 I 1.04 I229 T 1.33 L260 H 0.93 I229 P 1.22 L260 V 0.67 I229 N 1.04 L260 W 0.40 I229 S 0.92 L260 Q 0.37 I229 W 0.85 L260 A 0.34 I229 Q 0.69 L260 P 0.32 I229 F 0.60 L260 Y 0.30 I229 M 0.56 L260 G 0.22 I229 E 0.54 L260 K 0.15 I229 A 0.48 L260 S 0.11 I229 H 0.47 L260 E 0.07 I229 G 0.45 L260 T 0.05 I229 Y 0.42 L260 R 0.05 I229 K 0.24 L260 D 0.03 I229 D 0.17 I229 R 0.07 performance performance site variant index site variant index R198 D 0.68 V299 L 0.978 R198 G 0.39 V299 A 0.346 R198 V 0.36 V299 T 0.318 R198 T 0.19 V299 S 0.130 R198 S 0.15 V299 M 0.115 R198 H 0.15 V299 N 0.101 R198 A 0.11 V299 K 0.068 R198 C 0.11 V299 R 0.061 R198 I 0.10 V299 W 0.056 R198 M 0.09 V299 G 0.050 R198 N 0.03 V299 H 0.042 R198 F 0.02 V299 E 0.040 R198 Y 0.02 V299 Y 0.032 R198 H 0.01 V299 D 0.025 R198 L 0.01 V299 P 0.00 performance performance site variant index site variant index D311 M 3.10 D323 M 1.92 D311 F 1.46 D323 W 1.76 D311 L 1.23 D323 Y 1.38 D311 G 1.22 D323 F 1.33 D311 I 1.21 D323 I 1.27 D311 A 1.12 D323 S 1.22 D311 T 1.10 D323 V 1.10 D311 R 1.08 D323 N 1.07 D311 V 1.06 D323 A 1.03 D311 E 1.02 D323 G 1.03 D311 K 0.95 D323 Q 1.03 D311 S 0.89 D323 K 1.00 D311 W 0.82 D323 T 0.97 D311 Q 0.67 D323 L 0.93 D323 C 0.92 D323 R 0.90 D323 E 0.75 performance performance site variant index site variant index D345 Y 0.84 L303 I 1.11 D345 I 0.73 L303 M 1.07 D345 K 0.69 L303 V 0.93 D345 L 0.65 L303 C 0.85 D345 E 0.61 L303 S 0.78 D345 N 0.58 L303 E 0.77 D345 T 0.56 L303 W 0.74 D345 Q 0.56 L303 T 0.71 D345 G 0.55 L303 P 0.71 D345 V 0.51 L303 H 0.59 D345 A 0.50 L303 Q 0.58 D345 W 0.46 L303 G 0.55 D345 C 0.43 L303 D 0.54 D345 M 0.43 L303 A 0.52 D345 S 0.41 L303 R 0.49 D345 R 0.40 D345 P 0.35 performance performance site variant index site variant index A443 S 1.79 E451 G 0.16 A443 G 1.28 E451 K 0.15 A443 R 1.19 E451 S 0.14 A443 Q 1.01 E451 I 0.13 A443 H 0.28 E451 H 0.13 A443 L 0.27 E451 Q 0.13 A443 N 0.24 E451 V 0.12 A443 F 0.24 E451 L 0.12 A443 I 0.18 E451 F 0.12 A443 V 0.18 E451 Y 0.12 A443 T 0.12 E451 W 0.12 A443 P 0.10 E451 T 0.12 E451 D 0.12 E451 R 0.11 E451 N 0.10 E451 C 0.09 E451 A 0.09 E451 P 0.08 performance performance site variant index site variant index F388 L 1.06 N438 W 1.02 F388 Y 0.88 N438 K 0.34 F388 H 0.73 N438 P 0.31 F388 P 0.26 N438 I 0.29 F388 K 0.25 N438 R 0.28 F388 S 0.25 N438 V 0.20 F388 T 0.25 N438 Q 0.20 F388 Q 0.18 N438 L 0.19 F388 V 0.15 N438 M 0.18 F388 G 0.10 N438 S 0.17 F388 R 0.09 N438 H 0.16 F388 C 0.09 N438 Y 0.15 F388 D 0.09 N438 F 0.14 F388 A 0.08 N438 T 0.13 N438 C 0.12 N438 E 0.12 N438 G 0.11 N438 A 0.11 N438 D 0.11 performance performance site variant index site variant index N454 S 0.49 L494 P 2.64 N454 G 0.33 L494 C 1.89 N454 H 0.28 L494 I 1.71 N454 T 0.24 L494 V 1.57 N454 D 0.20 L494 S 1.38 N454 A 0.15 L494 G 1.30 N454 E 0.14 L494 D 1.04 N454 Q 0.11 L494 E 0.87 N454 L 0.05 L494 H 0.70 N454 W 0.05 L494 K 0.68 N454 F 0.03 L494 Y 0.66 N454 I 0.03 L494 Q 0.63 N454 Y 0.02 L494 N 0.58 N454 V 0.02 L494 R 0.41 N454 R 0.02 L494 A 0.39 N454 C 0.02 L494 W 0.37 N454 P 0.02 L494 T 0.08 N454 M 0.02 performance performance site variant index site variant index L469 A 1.45 A453 N 2.99 L469 Q 1.06 A453 I 1.77 L469 S 0.97 A453 V 1.08 L469 L 0.96 A453 T 0.53 L469 R 0.78 A453 Y 0.43 L469 I 0.75 A453 E 0.39 L469 V 0.74 A453 H 0.37 L469 C 0.71 A453 F 0.35 L469 H 0.66 A453 C 0.35 L469 T 0.63 A453 S 0.34 L469 F 0.60 A453 W 0.22 L469 N 0.57 A453 R 0.21 L469 Y 0.47 A453 D 0.10 L469 W 0.42 A453 K 0.05 L469 P 0.35 A453 P 0.03 L469 G 0.01 A453 G 0.02 performance performance site variant index site variant index A519 H 1.41 E525 S 1.62 A519 S 1.27 E525 T 1.25 A519 G 1.21 E525 R 1.24 A519 W 1.17 E525 K 1.22 A519 T 1.12 E525 V 1.17 A519 K 0.93 E525 H 1.09 A519 F 0.78 E525 L 1.07 A519 R 0.61 E525 F 1.05 A519 C 0.60 E525 W 1.05 A519 Q 0.58 E525 Q 1.05 A519 E 0.44 E525 G 1.00 A519 Y 0.42 E525 M 0.95 A519 V 0.40 E525 C 0.92 A519 L 0.39 E525 A 0.91 A519 D 0.23 E525 P 0.74 A519 P 0.04 E525 N 0.71 E525 D 0.68 performance performance site variant index site variant index H515 M 2.00 R528 K 1.00 H515 Q 1.05 R528 F 0.58 H515 N 0.97 R528 H 0.49 H515 R 0.97 R528 M 0.46 H515 G 0.93 R528 V 0.45 H515 H 0.81 R528 L 0.25 H515 Y 0.75 R528 Y 0.23 H515 I 0.72 R528 T 0.21 H515 A 0.71 R528 C 0.21 H515 E 0.64 R528 E 0.20 H515 F 0.59 R528 S 0.17 H515 D 0.59 R528 A 0.16 H515 L 0.58 R528 N 0.15 H515 V 0.56 R528 G 0.11 H515 C 0.50 R528 W 0.07 H515 T 0.50 R528 D 0.05 H515 W 0.43 R528 P 0.02 H515 S 0.38 H515 P 0.03 performance site variant index T536 F 3.60 T536 Y 2.62 T536 V 2.56 T536 I 2.44 T536 M 1.62 T536 H 1.50 T536 C 1.48 T536 L 1.43 T536 K 1.37 T536 A 1.31 T536 S 1.29 T536 G 1.04 T536 R 0.96 T536 N 0.55 T536 E 0.22 T536 D 0.18 T536 P 0.05

The entire library of T536, variants from all SELs which displayed the highest performance indices, and some control variants which displayed low performance indices were re-assayed for activity as described above. Table 5-4 shows the results from these assays. Results are presented as performance vs. wild-type (unmodified) molecule. Wild-type performance was determined as the average of 51 separate grown cultures. Results were variable between assays but results were in very good agreement with the primary screen results, indicating the assay is reliable. Beneficial sites for variation include but are not limited to flexible loop sites A453, H515, and A443; hydrophobic surface sites L494 and L469 and miscellaneous site T536. The highest performing variants, i.e. those that displayed a performance index greater than 1.5, were A453N, T536C, L494P, T5361, T536F, T536Y, and L494C.

TABLE 5-4 Performance indices of following retest. performance site variant index A453 N 2.31 T536 C 1.88 L494 P 1.82 T536 I 1.73 T536 F 1.73 T536 Y 1.73 L494 C 1.56 T536 A 1.48 L494 V 1.48 T536 K 1.46 T536 L 1.46 L494 G 1.39 T536 R 1.36 H515 M 1.34 A453 I 1.31 T536 V 1.27 A443 S 1.16 L494 I 1.10 T536 M 1.09 L469 A 1.09 D323 M 0.95 T536 H 0.94 T536 G 0.90 I229 V 0.89 I229 L 0.89 T536 S 0.72 T536 N 0.49 T536 D 0.17 T536 E 0.16 E451 S 0.14 R528 D 0.11 N438 E 0.10 E451 I 0.08 T536 P 0.08 R528 P 0.05

Example 6 P. alba Isoprene Synthase Combinatorial Analysis, Expression, Crystallization, Activity, and Tm

The P. alba isoprene synthase (IspS) SEL and enrichment studies identified several independent mutations displaying higher in vitro activity than the wild type (WT) enzyme. The experiments described below were aimed to determine if these mutations were mutually beneficial in combination with one another, and to determine if there were additional beneficial biochemical properties of any of the more active variants.

Methods

Three P. alba Isoprene Synthase (IspS) variants which demonstrated high performance index values relative to wild type in the SEL activity assay were chosen for further study. A fourth variant, previously isolated by a selection for randomly mutagenized IspS enzymes that tolerated protracted, high MVA pathway flux, was also included in the combinatorial analysis. These four variants harbored the mutations A453N, G491S (previously referred to as G507S), L494P, and T536C. In all possible combinations, these four mutations generated 16 possible variants of IspS. For ease of reference, the 16 variants to be assayed were annotated as containing the possible combinations of mutations N (A453N), S (G491S), P (L494P), or C (T536C), or WT (no mutations) in a given IspS molecule.

The 16 variants were based upon the vector backbone MD09-163 (encoding the WT enzyme, see FIG. 60), which harbors a TEV protease site and 6×His tag at the C-terminal end of IspS. Variants were generated using the QuikChange Multi Site-Directed Mutagenesis Kit (Stratagene) according to the manufacturer's recommended protocol (see below for PCR reaction and cycling parameters). Since the mutations encoding G491S and L494P are within six nucleotides of each other, it was necessary to use an oligonucleotide harboring both mutations in addition to the single oligonucleotides for those mutations in the QuikChange Multi reaction in order to generate all 16 possible combinations of mutations. The QuikChange Multi reaction was transformed into chemically competent E. coli TOP10 cells (Invitrogen) according to the manufacturer's recommended protocol and plated onto LB Kan50 selective media plates. Colonies resistant to kanamycin were directly screened by PCR and verified by sequencing using the primers QB1493 and T7 Reverse (Quintara Biosciences). In some cases, if a certain variant was not isolated from the QuickChange Multi reaction, a modified version of QuikChange Mutagenesis (Stratagene) was employed to generate a given variant (see below for PCR reaction and cycling parameters). These two techniques yielded all 16 possible combinatorial variants of N, S, P, or C, which were subjected to complete sequencing using the primers T7 Forward, EL-1000, QB1493, A-rev, A-rev2, and T7 Reverse (see Table 6-1). TOP10 cells were grown in selective medium, and plasmids were purified (Qiagen) and then transformed into chemically competent BL21 DE3 pLysS (Invitrogen) according to the manufacturer's recommended protocol, prior to expression of the IspS variants. All variants of IspS were purified and analyzed for specific activity relative to WT (see FIG. 62).

In a separate set of constructs, the T536F mutation (shown to be a thermostable variant of IspS) was also introduced into both the MD09-163 and pDW101 backbones. This mutation was introduced by the QuikChange mutagenesis methodology described above (see below for PCR reaction and cycling parameters), and similarly transformed into BL21 DE3 pLysS (Invitrogen) for expression. These variants were assayed for their effect on IspS expression and melting point relative to WT.

QuikChange Multi Site-Directed Mutagenesis

9 μl H₂O

2.5 μl 10× QuikChange Multi reaction buffer

0.5 μl QuikSolution

1 μl DNA template (100 ng MD09-163)

2 μl each primer (200 ng each of N, S, P, C, SP)

1 μl dNTP mix

1 μl QuikChange Multi enzyme blend

QuikChange Multi Site-Directed Mutagenesis—Cycling Parameters

1) 95° C.—4 min

2) 95° C.—1 min

3) 53° C.—1 min

4) 65° C.—14 min

5) goto Step 2—30×

6) 4° C.—for holding

QuikChange Mutagenesis (modified)

35 μl H₂O

5 μl 10×Pfu Ultra II r×n Buffer

6 μl 2.5 mM dNTPs (Roche)

1 μl 20 μM Primer 1 (e.g. G507S QC 2 For or alba T536F For)

1 μl 20 μM Primer 2 (e.g. G507S QC 2 Rev or alba T536F Rev)

1 μl Pfu Ultra II HS Polymerase (Stratagene)

1 μl DNA template (e.g. 100 ng MD09-163 or pDW101)

QuikChange Mutagenesis—Cycling Parameters

1) 95° C.—4 min

2) 95° C.—20 sec

3) 52° C.—20 sec

4) 68° C.—7 min

5) goto Step 2—5×

6) 95° C.—20 sec

7) 55° C.—20 sec

8) 68° C.—7 min

9) goto Step 2—20×

10) 68° C.—10 min

11) 4° C.—for holding

TABLE 6-1 Primers alba A453N For  gcgcgtggtgaaaccaacaatagcgtttctt (N) gttac (SEQ ID NO: 54) QC G507S For (S) agatgaacaaggaaaaactgagtggtagcct gttcgcgaaa (SEQ ID NO: 55) alba L494P For  gaaaaactgggtggtagcccgttcgcgaaac (P) cgttcg (SEQ ID NO: 56) alba T536C For  gttctgtctgtaatctgcgaaccgattctgc (C) cgtttg (SEQ ID NO: 57) alba G491S L494P gaacaaggaaaaactgagtggtagccc For (SP) gttcgcgaaaccgttcg (SEQ ID NO: 58) G507S QC 2 For gaaaaactgagtggtagcctgttcgcgaaac (SEQ ID NO: 59) G507S QC 2 Rev aggctaccactcagtttttccttgttcatct (SEQ ID NO: 60) alba T536F For gttctgtctgtaatctttgaaccgattctgc cgtttg (SEQ ID NO: 61) alba T536F Rev cggttcaaagattacagacagaacgcgtt (SEQ ID NO: 62) T7 Forward taatacgactcactataggg (SEQ ID NO: 48) T7 Reverse gctagttattgctcagcgg (SEQ ID NO: 49) EL-1000 gcactgtctttccgtctgctgc (SEQ ID NO: 50) A-rev ctcgtacaggctcaggatag (SEQ ID NO: 52) A-rev-2 ttacgtcccaacgctcaact (SEQ ID NO: 53) QB1493 cttcggcaacgcatggaaat (SEQ ID NO: 51)

TABLE 6-2 Plasmids: MD09-163 pET24a-P. alba TRC (MEA WT) C-Term (+) TEV, His tag pDW87 pET24a-P. alba TRC (MEA T536F) C-Term (+) TEV, His tag pDW95 pET24a-P. alba TRC (MEA L494P T536F) C-Term (+) TEV, His tag pDW99 pET24a-P. alba TRC (MEA A453N) C-Term (+) TEV, His tag pDW100 pET24a-P. alba TRC (MEA G491S) C-Term (+) TEV, His tag pDW101 pET24a-P. alba TRC (MEA L494P) C-Term (+) TEV, His tag pDW102 pET24a-P. alba TRC (MEA T536C) C-Term (+) TEV, His tag pDW103 pET24a-P. alba TRC (MEA A453N G491S) C-Term (+) TEV, His tag pDW104 pET24a-P. alba TRC (MEA A453N L494P) C-Term (+) TEV, His tag pDW105 pET24a-P. alba TRC (MEA A453N T536C) C-Term (+) TEV, His tag pDW106 pET24a-P. alba TRC (MEA A453N G491S L494P) C-Term (+) TEV, His tag pDW107 pET24a-P. alba TRC (MEA A453N G491S T536C) C-Term (+) TEV, His tag pDW108 pET24a-P. alba TRC (MEA A453N L494P T536C) C-Term (+) TEV, His tag pDW109 pET24a-P. alba TRC (MEA A453N G491S L494P T536C) C-Term (+) TEV, His tag pDW110 pET24a-P. alba TRC (MEA G491S L494P) C-Term (+) TEV, His tag pDW111 pET24a-P. alba TRC (MEA G491S T536C) C-Term (+) TEV, His tag pDW112 pET24a-P. alba TRC (MEA G491S L494P T536C) C-Term (+) TEV, His tag pDW113 pET24a-P. alba TRC (MEA L494P T536C) C-Term (+) TEV, His tag

TABLE 6-3 Strains: MD09-167 BL21(DE3) pLysS, MD09-163 (WT) DW363 BL21(DE3) pLysS, pDW87 DW381 BL21(DE3) pLysS, pDW95 DW397 BL21(DE3) pLysS, pDW99 (N) DW398 BL21(DE3) pLysS, pDW100 (S) DW399 BL21(DE3) pLysS, pDW101 (P) DW400 BL21(DE3) pLysS, pDW102 (C) DW401 BL21(DE3) pLysS, pDW103 (NS) DW402 BL21(DE3) pLysS, pDW104 (NP) DW403 BL21(DE3) pLysS, pDW105 (NC) DW404 BL21(DE3) pLysS, pDW106 (NSP) DW405 BL21(DE3) pLysS, pDW107 (NSC) DW406 BL21(DE3) pLysS, pDW108 (NPC) DW407 BL21(DE3) pLysS, pDW109 (NSPC) DW408 BL21(DE3) pLysS, pDW110 (SP) DW409 BL21(DE3) pLysS, pDW111 (SC) DW410 BL21(DE3) pLysS, pDW112 (SPC) DW411 BL21(DE3) pLysS, pDW1113 (PC)

1) Amino Acid Sequence of P. alba MEA(+)TEV − MD09-163 (WT) (SEQ ID NO: 63) MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH IFRLCNDLASASAEIARGETANSVSCYMRTKGISEELATESVMNLIDE TWKKMNKEKLGGSLFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR KRVLSVITEPILPFERENLYFQGLEHHHHHH

DNA sequence of MD09-163 (SEQ ID NO: 64) tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt tccccgtcaagctctaaatcgggggctccctttagggttccgatttag tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt ggagtccacgttctttaatagtggactcttgttccaaactggaacaac actcaaccctatctcggtctattcttttgatttataagggattttgcc gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc agttccataggatggcaagatcctggtatcggtctgcgattccgactc gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg catcaacaatattttcacctgaatcaggatattcttctaatacctgga atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt tatacccatataaatcagcatccatgttggaatttaatcgcggcctag agcaagacgtttcccgttgaatatggctcataacaccccttgtattac tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg atgccgcatagttaagccagtatacactccgctatcgctacgtgactg ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga gatatttatgccagccagccagacgcagacgcgccgagacagaactta atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg catactctgcgacatcgtataacgttactggtttcacattcaccaccc tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac tcactataggggaattgtgagcggataacaattcccctctagaaataa ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc gaatcaggttctgctggagctggcaattctggattacaacatgatcca gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga cgatatctacgatgtatacggcaccctggacgaactggagctgtttac tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga ttacatgaaactgtgctttctggctctgtataacactattaacgaaat cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccgcaaa tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa caaggaaaaactgggtggtagcctgttcgcgaaaccgttcgtggaaac cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt aatcactgaaccgattctgccgtttgaacgcgaaaacctgtattttca gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact agcataaccccttggggcctctaaacgggtcttgaggggttttttgct gaaaggaggaactatatccggat

2) Amino Acid Sequence of P. alba MEA A453N (+) TEV − pDW99 (N) (SEQ ID NO: 65) MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH IFRLCNDLASASAEIARGETNNSVSCYMRTKGISEELATESVMNLIDE TWKKMNKEKLGGSLFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR KRVLSITEPILPFERENLYFQGLEHHHHHH

DNA sequence of pDW99 (SEQ ID NO: 66) tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt tccccgtcaagctctaaatcgggggctccctttagggttccgatttag tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt ggagtccacgttctttaatagtggactcttgttccaaactggaacaac actcaaccctatctcggtctattcttttgatttataagggattttgcc gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc agttccataggatggcaagatcctggtatcggtctgcgattccgactc gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg catcaacaatattttcacctgaatcaggatattcttctaatacctgga atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt tatacccatataaatcagcatccatgttggaatttaatcgcggcctag agcaagacgtttcccgttgaatatggctcataacaccccttgtattac tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg atgccgcatagttaagccagtatacactccgctatcgctacgtgactg ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga gatatttatgccagccagccagacgcagacgcgccgagacagaactta atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg catactctgcgacatcgtataacgttactggtttcacattcaccaccc tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac tcactataggggaattgtgagcggataacaattcccctctagaaataa ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc gaatcaggttctgctggagctggcaattctggattacaacatgatcca gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga cgatatctacgatgtatacggcaccctggacgaactggagctgtttac tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga ttacatgaaactgtgctttctggctctgtataacactattaacgaaat cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccAACaa tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa caaggaaaaactgggtggtagcctgttcgcgaaaccgttcgtggaaac cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt aatcactgaaccgattctgccgtttgaacgcgaaaacctgtattttca gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact agcataaccccttggggcctctaaacgggtcttgaggggttttttgct gaaaggaggaactatatccggat

3) Amino Acid Sequence of P. alba MEA G491S (+) TEV − pDW100 (S) (SEQ ID NO: 67) MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH IFRLCNDLASASAEIARGETANSVSCYMRTKGISEELATESVMNLIDE TWKKMNKEKLSGSLFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR KRVLSVITEPILPFERENLYFQGLEHHHHHH

DNA sequence of pDW100 (SEQ ID NO: 68) tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt tccccgtcaagctctaaatcgggggctccctttagggttccgatttag tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt ggagtccacgttctttaatagtggactcttgttccaaactggaacaac actcaaccctatctcggtctattcttttgatttataagggattttgcc gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc agttccataggatggcaagatcctggtatcggtctgcgattccgactc gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg catcaacaatattttcacctgaatcaggatattcttctaatacctgga atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt tatacccatataaatcagcatccatgttggaatttaatcgcggcctag agcaagacgtttcccgttgaatatggctcataacaccccttgtattac tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg atgccgcatagttaagccagtatacactccgctatcgctacgtgactg ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga gatatttatgccagccagccagacgcagacgcgccgagacagaactta atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg catactctgcgacatcgtataacgttactggtttcacattcaccaccc tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac tcactataggggaattgtgagcggataacaattcccctctagaaataa ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc gaatcaggttctgctggagctggcaattctggattacaacatgatcca gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga cgatatctacgatgtatacggcaccctggacgaactggagctgtttac tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga ttacatgaaactgtgctttctggctctgtataacactattaacgaaat cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccgcaaa tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa caaggaaaaactgAGTggtagcctgttcgcgaaaccgttcgtggaaac cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt aatcactgaaccgattctgccgtttgaacgcgaaaacctgtattttca gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact agcataaccccttggggcctctaaacgggtcttgaggggttttttgct gaaaggaggaactatatccggat

4) Amino Acid Sequence of P. alba MEA L494P (+) TEV − pDW101 (P) (SEQ ID NO: 69) MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH IFRLCNDLASASAEIARGETANSVSCYMRTKGISEELATESVMNLIDE TWKKMNKEKLGGSPFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR KRVLSVITEPILPFERENLYFQGLEHHHHHH

DNA sequence of pDW101 (SEQ ID NO: 70) tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt tccccgtcaagctctaaatcgggggctccctttagggttccgatttag tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt ggagtccacgttctttaatagtggactcttgttccaaactggaacaac actcaaccctatctcggtctattcttttgatttataagggattttgcc gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc agttccataggatggcaagatcctggtatcggtctgcgattccgactc gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg catcaacaatattttcacctgaatcaggatattcttctaatacctgga atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt tatacccatataaatcagcatccatgttggaatttaatcgcggcctag agcaagacgtttcccgttgaatatggctcataacaccccttgtattac tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg atgccgcatagttaagccagtatacactccgctatcgctacgtgactg ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga gatatttatgccagccagccagacgcagacgcgccgagacagaactta atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg catactctgcgacatcgtataacgttactggtttcacattcaccaccc tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac tcactataggggaattgtgagcggataacaattcccctctagaaataa ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc gaatcaggttctgctggagctggcaattctggattacaacatgatcca gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga cgatatctacgatgtatacggcaccctggacgaactggagctgtttac tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga ttacatgaaactgtgctttctggctctgtataacactattaacgaaat cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccgcaaa tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa caaggaaaaactgggtggtagcCCGttcgcgaaaccgttcgtggaaac cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt aatcactgaaccgattctgccgtttgaacgcgaaaacctgtattttca gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact agcataaccccttggggcctctaaacgggtcttgaggggttttttgct gaaaggaggaactatatccggat

5) Amino Acid Sequence of P. alba MEA T536C (+) TEV − pDW102 (C) (SEQ ID NO: 71) MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH IFRLCNDLASASAEIARGETANSVSCYMRTKGISEELATESVMNLIDE TWKKMNKEKLGGSLFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR KRVLSVICEPILPFERENLYFQGLEHHHHHH

DNA sequence of pDW102 (SEQ ID NO: 72) tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt tccccgtcaagctctaaatcgggggctccctttagggttccgatttag tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt ggagtccacgttctttaatagtggactcttgttccaaactggaacaac actcaaccctatctcggtctattcttttgatttataagggattttgcc gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc agttccataggatggcaagatcctggtatcggtctgcgattccgactc gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg catcaacaatattttcacctgaatcaggatattcttctaatacctgga atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt tatacccatataaatcagcatccatgttggaatttaatcgcggcctag agcaagacgtttcccgttgaatatggctcataacaccccttgtattac tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg atgccgcatagttaagccagtatacactccgctatcgctacgtgactg ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga gatatttatgccagccagccagacgcagacgcgccgagacagaactta atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg catactctgcgacatcgtataacgttactggtttcacattcaccaccc tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac tcactataggggaattgtgagcggataacaattcccctctagaaataa ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc gaatcaggttctgctggagctggcaattctggattacaacatgatcca gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga cgatatctacgatgtatacggcaccctggacgaactggagctgtttac tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga ttacatgaaactgtgctttctggctctgtataacactattaacgaaat cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccgcaaa tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa caaggaaaaactgggtggtagcctgttcgcgaaaccgttcgtggaaac cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt aatcTGCgaaccgattctgccgtttgaacgcgaaaacctgtattttca gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact agcataaccccttggggcctctaaacgggtcttgaggggttttttgct gaaaggaggaactatatccggat

6) Amino Acid Sequence of P. alba MEA A453N G491S (+)TEV − pDW103 (NS) (SEQ ID NO: 73) MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH IFRLCNDLASASAEIARGETNNSVSCYMRTKGISEELATESVMNLIDE TWKKMNKEKLSGSLFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR KRVLSVITEPILPFERENLYFQGLEHHHHHH

DNA sequence of pDW103 (SEQ ID NO: 74) tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt tccccgtcaagctctaaatcgggggctccctttagggttccgatttag tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt ggagtccacgttctttaatagtggactcttgttccaaactggaacaac actcaaccctatctcggtctattcttttgatttataagggattttgcc gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc agttccataggatggcaagatcctggtatcggtctgcgattccgactc gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg catcaacaatattttcacctgaatcaggatattcttctaatacctgga atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt tatacccatataaatcagcatccatgttggaatttaatcgcggcctag agcaagacgtttcccgttgaatatggctcataacaccccttgtattac tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg atgccgcatagttaagccagtatacactccgctatcgctacgtgactg ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga gatatttatgccagccagccagacgcagacgcgccgagacagaactta atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg catactctgcgacatcgtataacgttactggtttcacattcaccaccc tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac tcactataggggaattgtgagcggataacaattcccctctagaaataa ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc gaatcaggttctgctggagctggcaattctggattacaacatgatcca gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcg acgatatctacgatgtatacggcaccctggacgaactggagctgttta ctgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgg attacatgaaactgtgctttctggctctgtataacactattaacgaaa tcgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatc tgaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagcca agtggctgtacaacaaatctactccgacctttgacgactacttcggca acgcatggaaatcctcttctggcccgctgcaactggtgttcgcttact tcgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaa aataccatgacaccatctctcgtccttcccatatcttccgtctgtgca atgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccaaca atagcgtttcttgttacatgcgcactaaaggtatctccgaagaactgg ctaccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatga acaaggaaaaactgAGTggtagcctgttcgcgaaaccgttcgtggaaa ccgcgatcaacctggcacgtcaatctcactgcacttatcataacggcg acgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctg taatcactgaaccgattctgccgtttgaacgcgaaaacctgtattttc agggcctcgagcaccaccaccaccaccactgagatccggctgctaaca aagcccgaaaggaagctgagttggctgctgccaccgctgagcaataac tagcataaccccttggggcctctaaacgggtcttgaggggttttttgc tgaaaggaggaactatatccggat

7) Amino Acid Sequence of P. alba MEA A453N L494P (+)TEV − pDW104 (NP) (SEQ ID NO: 75) MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH IFRLCNDLASASAEIARGETNNSVSCYMRTKGISEELATESVMNLIDE TWKKMNKEKLGGSPFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR KRVLSVITEPILPFERENLYFQGLEHHHHHH

DNA sequence of pDW104 (SEQ ID NO: 76) tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt tccccgtcaagctctaaatcgggggctccctttagggttccgatttag tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt ggagtccacgttctttaatagtggactcttgttccaaactggaacaac actcaaccctatctcggtctattcttttgatttataagggattttgcc gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc agttccataggatggcaagatcctggtatcggtctgcgattccgactc gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg catcaacaatattttcacctgaatcaggatattcttctaatacctgga atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt tatacccatataaatcagcatccatgttggaatttaatcgcggcctag agcaagacgtttcccgttgaatatggctcataacaccccttgtattac tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg atgccgcatagttaagccagtatacactccgctatcgctacgtgactg ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga gatatttatgccagccagccagacgcagacgcgccgagacagaactta atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg catactctgcgacatcgtataacgttactggtttcacattcaccaccc tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac tcactataggggaattgtgagcggataacaattcccctctagaaataa ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc gaatcaggttctgctggagctggcaattctggattacaacatgatcca gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga cgatatctacgatgtatacggcaccctggacgaactggagctgtttac tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga ttacatgaaactgtgctttctggctctgtataacactattaacgaaat cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccaacaa tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa caaggaaaaactgggtggtagcccgttcgcgaaaccgttcgtggaaac cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt aatcactgaaccgattctgccgtttgaacgcgaaaacctgtattttca gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact agcataaccccttggggcctctaaacgggtcttgaggggttttttgct gaaaggaggaactatatccggat

8) Amino Acid Sequence of P. alba MEA A453N T536C (+)TEV − pDW105 (NC) (SEQ ID NO: 77) MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH IFRLCNDLASASAEIARGETNNSVSCYMRTKGISEELATESVMNLIDE TWKKMNKEKLGGSLFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR KRVLSVICEPILPFERENLYFQGLEHHHHHH

DNA sequence of pDW105 (SEQ ID NO: 78) tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt tccccgtcaagctctaaatcgggggctccctttagggttccgatttag tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt ggagtccacgttctttaatagtggactcttgttccaaactggaacaac actcaaccctatctcggtctattcttttgatttataagggattttgcc gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc agttccataggatggcaagatcctggtatcggtctgcgattccgactc gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg catcaacaatattttcacctgaatcaggatattcttctaatacctgga atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt tatacccatataaatcagcatccatgttggaatttaatcgcggcctag agcaagacgtttcccgttgaatatggctcataacaccccttgtattac tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg atgccgcatagttaagccagtatacactccgctatcgctacgtgactg ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga gatatttatgccagccagccagacgcagacgcgccgagacagaactta atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg catactctgcgacatcgtataacgttactggtttcacattcaccaccc tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac tcactataggggaattgtgagcggataacaattcccctctagaaataa ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc gaatcaggttctgctggagctggcaattctggattacaacatgatcca gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga cgatatctacgatgtatacggcaccctggacgaactggagctgtttac tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga ttacatgaaactgtgctttctggctctgtataacactattaacgaaat cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccaacaa tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa caaggaaaaactgggtggtagcctgttcgcgaaaccgttcgtggaaac cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt aatctgcgaaccgattctgccgtttgaacgcgaaaacctgtattttca gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact agcataaccccttggggcctctaaacgggtcttgaggggttttttgct gaaaggaggaactatatccggat

9) Amino Acid Sequence of P. alba MEA A453N G491S L494P (+)TEV − pDW106 (NSP) (SEQ ID NO: 79) MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH IFRLCNDLASASAEIARGETNNSVSCYMRTKGISEELATESVMNLIDE TWKKMNKEKLSGSPFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR KRVLSVITEPILPFERENLYFQGLEHHHHHH

DNA sequence of pDW106 (SEQ ID NO: 80) tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt tccccgtcaagctctaaatcgggggctccctttagggttccgatttag tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt ggagtccacgttctttaatagtggactcttgttccaaactggaacaac actcaaccctatctcggtctattcttttgatttataagggattttgcc gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc agttccataggatggcaagatcctggtatcggtctgcgattccgactc gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg catcaacaatattttcacctgaatcaggatattcttctaatacctgga atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt tatacccatataaatcagcatccatgttggaatttaatcgcggcctag agcaagacgtttcccgttgaatatggctcataacaccccttgtattac tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg atgccgcatagttaagccagtatacactccgctatcgctacgtgactg ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga gatatttatgccagccagccagacgcagacgcgccgagacagaactta atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg catactctgcgacatcgtataacgttactggtttcacattcaccaccc tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac tcactataggggaattgtgagcggataacaattcccctctagaaataa ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc gaatcaggttctgctggagctggcaattctggattacaacatgatcca gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga cgatatctacgatgtatacggcaccctggacgaactggagctgtttac tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga ttacatgaaactgtgctttctggctctgtataacactattaacgaaat cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccaacaa tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa caaggaaaaactgagtggtagcccgttcgcgaaaccgttcgtggaaac cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt aatcactgaaccgattctgccgtttgaacgcgaaaacctgtattttca gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact agcataaccccttggggcctctaaacgggtcttgaggggttttttgct gaaaggaggaactatatccggat

10) Amino Acid Sequence of P. alba MEA A453N G491S T536C (+)TEV − pDW107 (NSC) (SEQ ID NO: 81) MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH IFRLCNDLASASAEIARGETNNSVSCYMRTKGISEELATESVMNLIDE TWKKMNKEKLSGSLFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR KRVLSVICEPILPFERENLYFQGLEHHHHHH

DNA sequence of pDW107 (SEQ ID NO: 82) tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt tccccgtcaagctctaaatcgggggctccctttagggttccgatttag tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt ggagtccacgttctttaatagtggactcttgttccaaactggaacaac actcaaccctatctcggtctattcttttgatttataagggattttgcc gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc agttccataggatggcaagatcctggtatcggtctgcgattccgactc gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg catcaacaatattttcacctgaatcaggatattcttctaatacctgga atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt tatacccatataaatcagcatccatgttggaatttaatcgcggcctag agcaagacgtttcccgttgaatatggctcataacaccccttgtattac tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg atgccgcatagttaagccagtatacactccgctatcgctacgtgactg ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga gatatttatgccagccagccagacgcagacgcgccgagacagaactta atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg catactctgcgacatcgtataacgttactggtttcacattcaccaccc tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac tcactataggggaattgtgagcggataacaattcccctctagaaataa ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc gaatcaggttctgctggagctggcaattctggattacaacatgatcca gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga cgatatctacgatgtatacggcaccctggacgaactggagctgtttac tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga ttacatgaaactgtgctttctggctctgtataacactattaacgaaat cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccaacaa tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa caaggaaaaactgagtggtagcctgttcgcgaaaccgttcgtggaaac cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt aatctgcgaaccgattctgccgtttgaacgcgaaaacctgtattttca gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact agcataaccccttggggcctctaaacgggtcttgaggggttttttgct gaaaggaggaactatatccggat

11) Amino Acid Sequence of P. alba MEA A453N L494P T536C (+)TEV − pDW108 (NPC) (SEQ ID NO: 83) MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH IFRLCNDLASASAEIARGETNNSVSCYMRTKGISEELATESVMNLIDE TWKKMNKEKLGGSPFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR KRVLSVICEPILPFERENLYFQGLEHHHHHH

DNA sequence of pDW108 (SEQ ID NO: 84) tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt tccccgtcaagctctaaatcgggggctccctttagggttccgatttag tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt ggagtccacgttctttaatagtggactcttgttccaaactggaacaac actcaaccctatctcggtctattcttttgatttataagggattttgcc gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc agttccataggatggcaagatcctggtatcggtctgcgattccgactc gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg catcaacaatattttcacctgaatcaggatattcttctaatacctgga atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt tatacccatataaatcagcatccatgttggaatttaatcgcggcctag agcaagacgtttcccgttgaatatggctcataacaccccttgtattac tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg atgccgcatagttaagccagtatacactccgctatcgctacgtgactg ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga gatatttatgccagccagccagacgcagacgcgccgagacagaactta atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg catactctgcgacatcgtataacgttactggtttcacattcaccaccc tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac tcactataggggaattgtgagcggataacaattcccctctagaaataa ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc gaatcaggttctgctggagctggcaattctggattacaacatgatcca gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga cgatatctacgatgtatacggcaccctggacgaactggagctgtttac tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga ttacatgaaactgtgctttctggctctgtataacactattaacgaaat cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccaacaa tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa caaggaaaaactgggtggtagcccgttcgcgaaaccgttcgtggaaac cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt aatctgcgaaccgattctgccgtttgaacgcgaaaacctgtattttca gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact agcataaccccttggggcctctaaacgggtcttgaggggttttttgct gaaaggaggaactatatccggat

12) Amino Acid Sequence of P. alba MEA A453N G491S L494P T536C (+)TEV − pDW109 (NSPC) (SEQ ID NO: 85) MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH IFRLCNDLASASAEIARGETNNSVSCYMRTKGISEELATESVMNLIDE TWKKMNKEKLSGSPFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR KRVLSVICEPILPFERENLYFQGLEHHHHHH

DNA sequence of pDW109 (SEQ ID NO: 86) tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt tccccgtcaagctctaaatcgggggctccctttagggttccgatttag tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt ggagtccacgttctttaatagtggactcttgttccaaactggaacaac actcaaccctatctcggtctattcttttgatttataagggattttgcc gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc agttccataggatggcaagatcctggtatcggtctgcgattccgactc gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg catcaacaatattttcacctgaatcaggatattcttctaatacctgga atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt tatacccatataaatcagcatccatgttggaatttaatcgcggcctag agcaagacgtttcccgttgaatatggctcataacaccccttgtattac tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg atgccgcatagttaagccagtatacactccgctatcgctacgtgactg ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga gatatttatgccagccagccagacgcagacgcgccgagacagaactta atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg catactctgcgacatcgtataacgttactggtttcacattcaccaccc tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac tcactataggggaattgtgagcggataacaattcccctctagaaataa ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc gaatcaggttctgctggagctggcaattctggattacaacatgatcca gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga cgatatctacgatgtatacggcaccctggacgaactggagctgtttac tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga ttacatgaaactgtgctttctggctctgtataacactattaacgaaat cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccaacaa tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa caaggaaaaactgagtggtagcccgttcgcgaaaccgttcgtggaaac cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt aatctgcgaaccgattctgccgtttgaacgcgaaaacctgtattttca gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact agcataaccccttggggcctctaaacgggtcttgaggggttttttgct gaaaggaggaactatatccggat

13) Amino Acid Sequence of P. alba MEA G491S L494P (+)TEV − pDW110 (SP) (SEQ ID NO: 87) MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH IFRLCNDLASASAEIARGETANSVSCYMRTKGISEELATESVMNLIDE TWKKMNKEKLSGSPFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR KRVLSVITEPILPFERENLYFQGLEHHHHHH

DNA sequence of pDW110 (SEQ ID NO: 88) tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt tccccgtcaagctctaaatcgggggctccctttagggttccgatttag tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt ggagtccacgttctttaatagtggactcttgttccaaactggaacaac actcaaccctatctcggtctattcttttgatttataagggattttgcc gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc agttccataggatggcaagatcctggtatcggtctgcgattccgactc gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg catcaacaatattttcacctgaatcaggatattcttctaatacctgga atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt tatacccatataaatcagcatccatgttggaatttaatcgcggcctag agcaagacgtttcccgttgaatatggctcataacaccccttgtattac tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg atgccgcatagttaagccagtatacactccgctatcgctacgtgactg ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga gatatttatgccagccagccagacgcagacgcgccgagacagaactta atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg catactctgcgacatcgtataacgttactggtttcacattcaccaccc tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac tcactataggggaattgtgagcggataacaattcccctctagaaataa ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc gaatcaggttctgctggagctggcaattctggattacaacatgatcca gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga cgatatctacgatgtatacggcaccctggacgaactggagctgtttac tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga ttacatgaaactgtgctttctggctctgtataacactattaacgaaat cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccgcaaa tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa caaggaaaaactgagtggtagcccgttcgcgaaaccgttcgtggaaac cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt aatcactgaaccgattctgccgtttgaacgcgaaaacctgtattttca gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact agcataaccccttggggcctctaaacgggtcttgaggggttttttgct gaaaggaggaactatatccggat

14) Amino Acid Sequence of P. alba MEA G491S T536C (+)TEV − pDW111 (SC) (SEQ ID NO: 89) MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH IFRLCNDLASASAEIARGETANSVSCYMRTKGISEELATESVMNLIDE TWKKMNKEKLSGSLFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR KRVLSVICEPILPFERENLYFQGLEHHHHHH

DNA sequence of pDW111 (SEQ ID NO: 90) tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt tccccgtcaagctctaaatcgggggctccctttagggttccgatttag tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt ggagtccacgttctttaatagtggactcttgttccaaactggaacaac actcaaccctatctcggtctattcttttgatttataagggattttgcc gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc agttccataggatggcaagatcctggtatcggtctgcgattccgactc gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg catcaacaatattttcacctgaatcaggatattcttctaatacctgga atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt tatacccatataaatcagcatccatgttggaatttaatcgcggcctag agcaagacgtttcccgttgaatatggctcataacaccccttgtattac tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg atgccgcatagttaagccagtatacactccgctatcgctacgtgactg ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga gatatttatgccagccagccagacgcagacgcgccgagacagaactta atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg catactctgcgacatcgtataacgttactggtttcacattcaccaccc tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac tcactataggggaattgtgagcggataacaattcccctctagaaataa ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc gaatcaggttctgctggagctggcaattctggattacaacatgatcca gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga cgatatctacgatgtatacggcaccctggacgaactggagctgtttac tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga ttacatgaaactgtgctttctggctctgtataacactattaacgaaat cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccgcaaa tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa caaggaaaaactgagtggtagcctgttcgcgaaaccgttcgtggaaac cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt aatctgcgaaccgattctgccgtttgaacgcgaaaacctgtattttca gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact agcataaccccttggggcctctaaacgggtcttgaggggttttttgct gaaaggaggaactatatccggat

15) Amino Acid Sequence of P. alba MEA G491S L494P T536C (+)TEV − pDW112 (SPC) (SEQ ID NO: 91) MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH IFRLCNDLASASAEIARGETANSVSCYMRTKGISEELATESVMNLIDE TWKKMNKEKLSGSPFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR KRVLSVICEPILPFERENLYFQGLEHHHHHH

DNA sequence of pDW112 (SEQ ID NO: 92) tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt tccccgtcaagctctaaatcgggggctccctttagggttccgatttag tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt ggagtccacgttctttaatagtggactcttgttccaaactggaacaac actcaaccctatctcggtctattcttttgatttataagggattttgcc gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc agttccataggatggcaagatcctggtatcggtctgcgattccgactc gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg catcaacaatattttcacctgaatcaggatattcttctaatacctgga atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt tatacccatataaatcagcatccatgttggaatttaatcgcggcctag agcaagacgtttcccgttgaatatggctcataacaccccttgtattac tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg atgccgcatagttaagccagtatacactccgctatcgctacgtgactg ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga gatatttatgccagccagccagacgcagacgcgccgagacagaactta aatgggcccgctaacagcgcgatttgctggtgacccaatgcgaccaga tgctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactg ttgatgggtgtctggtcagagacatcaagaaataacgccggaacatta gtgcaggcagcttccacagcaatggcatcctggtcatccagcggatag ttaatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgcc gctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacg ctggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgc gacggcgcgtgcagggccagactggaggtggcaacgccaatcagcaac gactgtttgcccgccagttgttgtgccacgcggttgggaatgtaattc agctccgccatcgccgcttccactttttcccgcgttttcgcagaaacg tggctggcctggttcaccacgcgggaaacggtctgataagagacaccg gcatactctgcgacatcgtataacgttactggtttcacattcaccacc ctgaattgactctcttccgggcgctatcatgccataccgcgaaaggtt ttgcgccattcgatggtgtccgggatctcgacgctctcccttatgcga ctcctgcattaggaagcagcccagtagtaggttgaggccgttgagcac cgccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtcc cccggccacggggcctgccaccatacccacgccgaaacaagcgctcat gagcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgat ataggcgccagcaaccgcacctgtggcgccggtgatgccggccacgat gcgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacga ctcactataggggaattgtgagcggataacaattcccctctagaaata attttgtttaactttaagaaggagatatacatatggaagctcgtcgtt ctgcgaactacgaacctaacagctgggactatgattacctgctgtcct ccgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagc tggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttc tgaccctgctggaactgattgacaacgtccagcgcctgggcctgggtt accgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcct ccggcggcttcgatgcggtaaccaagacttccctgcacggtacggcac tgtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaag cgttcagcggcttcaaagaccaaaacggcaacttcctggagaacctga aggaagatatcaaagctatcctgagcctgtacgaggccagcttcctgg ctctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatct ctcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcag aacaggtgaaccatgcactggaactgccactgcatcgccgtactcagc gtctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacg cgaatcaggttctgctggagctggcaattctggattacaacatgatcc agtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtc gtgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattg agagcttctactgggccgtgggtgtagcattcgaaccgcaatactccg actgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcg acgatatctacgatgtatacggcaccctggacgaactggagctgttta ctgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgg attacatgaaactgtgctttctggctctgtataacactattaacgaaa tcgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatc tgaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagcca agtggctgtacaacaaatctactccgacctttgacgactacttcggca acgcatggaaatcctcttctggcccgctgcaactggtgttcgcttact tcgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaa aataccatgacaccatctctcgtccttcccatatcttccgtctgtgca atgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccgcaa atagcgtttcttgttacatgcgcactaaaggtatctccgaagaactgg ctaccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatga acaaggaaaaactgagtggtagcccgttcgcgaaaccgttcgtggaaa ccgcgatcaacctggcacgtcaatctcactgcacttatcataacggcg acgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctg taatctgcgaaccgattctgccgtttgaacgcgaaaacctgtattttc agggcctcgagcaccaccaccaccaccactgagatccggctgctaaca aagcccgaaaggaagctgagttggctgctgccaccgctgagcaataac tagcataaccccttggggcctctaaacgggtcttgaggggttttttgc tgaaaggaggaactatatccggat

16) Amino Acid Sequence of P. alba MEA L494P T536C (+)TEV − pDW113 (PC) (SEQ ID NO: 93) MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH IFRLCNDLASASAEIARGETANSVSCYMRTKGISEELATESVMNLIDE TWKKMNKEKLGGSPFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR KRVLSVICEPILPFERENLYFQGLEHHHHHH

DNA sequence of pDW113 (SEQ ID NO: 94) tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt tccccgtcaagctctaaatcgggggctccctttagggttccgatttag tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt ggagtccacgttctttaatagtggactcttgttccaaactggaacaac actcaaccctatctcggtctattcttttgatttataagggattttgcc gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc agttccataggatggcaagatcctggtatcggtctgcgattccgactc gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg catcaacaatattttcacctgaatcaggatattcttctaatacctgga atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt tatacccatataaatcagcatccatgttggaatttaatcgcggcctag agcaagacgtttcccgttgaatatggctcataacaccccttgtattac tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg atgccgcatagttaagccagtatacactccgctatcgctacgtgactg ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga gatatttatgccagccagccagacgcagacgcgccgagacagaactta atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg catactctgcgacatcgtataacgttactggtttcacattcaccaccc tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac tcactataggggaattgtgagcggataacaattcccctctagaaataa ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc gaatcaggttctgctggagctggcaattctggattacaacatgatcca gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga cgatatctacgatgtatacggcaccctggacgaactggagctgtttac tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga ttacatgaaactgtgctttctggctctgtataacactattaacgaaat cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccgcaaa tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa caaggaaaaactgggtggtagcccgttcgcgaaaccgttcgtggaaac cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt aatctgcgaaccgattctgccgtttgaacgcgaaaacctgtattttca gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact agcataaccccttggggcctctaaacgggtcttgaggggttttttgct gaaaggaggaactatatccggat

Amino Acid Sequence of P. alba MEA T536F (+)TEV − pDW87 (SEQ ID NO: 95) MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH IFRLCNDLASASAEIARGETANSVSCYMRTKGISEELATESVMNLIDE TWKKMNKEKLGGSLFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR KRVLSVIFEPILPFERENLYFQGLEHHHHHH

DNA sequence of pDW87 (SEQ ID NO: 96) tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt tccccgtcaagctctaaatcgggggctccctttagggttccgatttag tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt ggagtccacgttctttaatagtggactcttgttccaaactggaacaac actcaaccctatctcggtctattcttttgatttataagggattttgcc gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc agttccataggatggcaagatcctggtatcggtctgcgattccgactc gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg catcaacaatattttcacctgaatcaggatattcttctaatacctgga atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt tatacccatataaatcagcatccatgttggaatttaatcgcggcctag agcaagacgtttcccgttgaatatggctcataacaccccttgtattac tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg atgccgcatagttaagccagtatacactccgctatcgctacgtgactg ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga gatatttatgccagccagccagacgcagacgcgccgagacagaactta atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg catactctgcgacatcgtataacgttactggtttcacattcaccaccc tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac tcactataggggaattgtgagcggataacaattcccctctagaaataa ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc gaatcaggttctgctggagctggcaattctggattacaacatgatcca gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga cgatatctacgatgtatacggcaccctggacgaactggagctgtttac tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga ttacatgaaactgtgctttctggctctgtataacactattaacgaaat cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccgcaaa tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa caaggaaaaactgggtggtagcctgttcgcgaaaccgttcgtggaaac cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt aatctttgaaccgattctgccgtttgaacgcgaaaacctgtattttca gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact agcataaccccttggggcctctaaacgggtcttgaggggttttttgct gaaaggaggaactatatccggat

Amino Acid Sequence of P. alba MEA L494P T536F (+)TEV − pDW95 (SEQ ID NO: 97) MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH IFRLCNDLASASAEIARGETANSVSCYMRTKGISEELATESVMNLIDE TWKKMNKEKLGGSPFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR KRVLSVIFEPILPFERENLYFQGLEHHHHHH

DNA sequence of pDW95 (SEQ ID NO: 98) tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt tccccgtcaagctctaaatcgggggctccctttagggttccgatttag tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt ggagtccacgttctttaatagtggactcttgttccaaactggaacaac actcaaccctatctcggtctattcttttgatttataagggattttgcc gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc agttccataggatggcaagatcctggtatcggtctgcgattccgactc gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg catcaacaatattttcacctgaatcaggatattcttctaatacctgga atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt tatacccatataaatcagcatccatgttggaatttaatcgcggcctag agcaagacgtttcccgttgaatatggctcataacaccccttgtattac tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg atgccgcatagttaagccagtatacactccgctatcgctacgtgactg ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga gatatttatgccagccagccagacgcagacgcgccgagacagaactta atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg catactctgcgacatcgtataacgttactggtttcacattcaccaccc tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac tcactataggggaattgtgagcggataacaattcccctctagaaataa ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc gaatcaggttctgctggagctggcaattctggattacaacatgatcca gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga cgatatctacgatgtatacggcaccctggacgaactggagctgtttac tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga ttacatgaaactgtgctttctggctctgtataacactattaacgaaat cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccgcaaa tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa caaggaaaaactgggtggtagcccgttcgcgaaaccgttcgtggaaac cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt aatctttgaaccgattctgccgtttgaacgcgaaaacctgtattttca gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact agcataaccccttggggcctctaaacgggtcttgaggggttttttgct gaaaggaggaactatatccggat

Example 7 Biochemical Analysis of P. alba IspS Variants

As denoted in Example 8, P (L494P), SP (G491S, L494P) and SPC (G491S, L494P, T536C) isoprene synthase amino acid variants were determined to contain increased specific activity compared to WT isoprene synthase with the P variant containing the greatest specific activity (2.0 times greater than WT). The KMs of the P, SP, and SPC isoprene synthase amino acid variants were less than the KM of the WT isoprene synthase. In addition, the kcat of the β isoprene synthase amino acid variant was greater than the WT isoprene synthase. These results indicate that the P, SP and SPC amino acid variants of isoprene synthase may improve the efficiency (isoprene production rate/[Isoprene synthase]) of production of isoprene in vivo leading to an improved process for isoprene production.

Methods

Materials:

Lysis Buffer: Ni wash+0.5 mM PMST, 0.01% Tween-20, 1 mg/ml lysozyme, 0.2 mg/ml DNase

Ni wash buffer: 50 mM NaH2PO4, 300 mM NaCl, 20 mM Imidazole, pH 8.0

Ni elution buffer: 50 mM NaH2PO4, 300 mM NaCl, 500 mM Imidazole, pH 8.0

PD-10 buffer: 50 mM Tris, 0.05 M NaCl, pH 8.0

Expression:

1. Overnight culture grown in 3 mL of LB broth at 30 C with Kan₅₀, Chlor₂₅

2. Transfer 50 uL of overnight culture into 100 mL of fresh LB with antibiotic

3. Grow at 37 C, 250 RPM for 3.5 hours

4. Induce with 400 uM IPTG at OD600˜0.4

5. Reduce temp to 30 C and shake for 4 hours.

6. Transfer cells into 50 mL tubes and spin 25 min at 3800 RPM

7. Decant supernatant and repeat centrifugation step with remaining media

8. Decant supernatant

9. Store pellets at −80 C

Purification:

1. Initial Purification—Resuspend the pellet in 3 ml of fresh lysis buffer. Break cells by passing them through the French Press using the small cylinder. Centrifuge samples for 1 hour at 30,000×G and collect the supernatant. Retain pellet in order to test for presence of insoluble protein. Pre equilibrate 0.5 mL Ni Sepharose 6 Fast Flow resin (Amersham) in a 20 ml disposable column with 10 mL of Ni wash buffer. Add protein to column and shake for 60 min at 4 C to bind protein. Elute protein with 2.5 mL Ni elution buffer.

2. Buffer Exchange—Equilibrate a PD-10 column (GE Healthcare) with 25 mL of PD-10 buffer. Load protein on to column and elute with 3.5 mL of PD-10 buffer.

3. Analyze samples using SDS-PAGE to determine relative purity of pellet (p), supernatant (s), and after both columns (ni).

4. Aliquot protein and store at −80 C.

Specific Activity Measurement—

10 uL of purified enzyme was incubated with 4 mM DMAPP, 50 mM MgCl2 in a buffer containing 50 mM Tris and 50 mM NaCl (pH=8) to a final volume of 100 uL for 15 min. at 30 C in gas tight 2 mL vials. Reactions were terminated with the addition of 100 uL of 250 uM EDTA, pH=8. Samples were analyzed by GC-MS to determine the concentration of isoprene in the headspace of the vials. All specific activity measurements were performed in triplicate.

k_(cat) and K_(M) Determination—

10 uL of purified enzyme was incubated with DMAPP at concentrations ranging from 1.25 to 20 mM DMAPP in a buffer containing 50 mM Tris, 50 mM MgCl2 and 50 mM NaCl (pH=8) to a final volume of 100 uL for 15 min. at 30 C in gas tight 2 mL vials. Reactions were terminated with the addition of 100 uL of 250 mM EDTA, pH=8. Samples were analyzed by GC-MS to determine the concentration of isoprene in the headspace of the vials. Data were analyzed using Kaleidagraph and fit to following equation for uncompetitive substrate inhibition: rate/E=kcat*S/(KM+S*(1+S/Ki)). All kinetic assays were performed in triplicate.

Protein Concentration Determination—

Protein concentration was determined by measuring the absorbance of each protein solution at 280 nm on a Helwlett Pachard 8453 UV-Vis spectrophotometer and converting the absorbance to protein concentration using the extinction coefficient as determined on the Expasy website (Gasteiger E., Hoogland C., Gattiker A., Duvaud S., Wilkins M. R., Appel R. D., Bairoch A.; Protein Identification and Analysis Tools on the ExPASy Server; (In) John M. Walker (ed): The Proteomics Protocols Handbook, Humana Press (2005). pp. 571-607). The protein concentrations of isoprene synthase variants assayed for K_(M) and k_(cat) determination were verified by comparative gel electrophoresis of a dilution series of each protein (FIG. 61).

Results/Discussion:

The specific activity of each protein was determined (FIG. 62 and Table 7-4). The specific activity of the β isoprene synthase amino acid variant was 2-fold greater than the specific activity of the WT isoprene synthase. The specific activities of the SP and SPC variants were greater than the WT isoprene synthase but less than the P isoprene synthase variant. All other isoprene synthases tested in this study displayed equal or decreased activity compared to the WT isoprene synthase.

The rate of conversion of DMAPP to isoprene was analyzed over a range of DMAPP concentrations in order to determine the kcat and KM parameters for WT, P, SP and SPC isoprene synthase amino acid variants (FIG. 63, Table 7-5). The enzymes all exhibited rate profiles consistent with uncompetitive substrate inhibition by DMAPP. The KMs of the P, SP, and SPC isoprene synthase variants were less than the KM of the WT isoprene synthase. In addition, the kcat of the β isoprene synthase variant was greater than the kcat of the WT isoprene synthase (Table 7-5)

The L494 residue was chosen for SEL studies because it is a hydrophobic residue within a surface-exposed loop of P. alba IspS. However, we observed that proline is conserved at this site in an alignment of other terpene synthase enzymes. Other Populus species isoprene synthases, along with IspS from P. Montana (Kudzu), and various other terpene synthase enzymes such as M. spicata limonene synthase, S. officinalis bornyl diphosphate synthase, N. tabacum epi-aristolochene synthase were aligned relative to P. alba IspS using the ClustalW algorithm in AlignX of the Vector NTI software (Invitrogen). FIG. 59 shows that at position 494, many other terpene synthase enzymes have a proline residue, suggesting that proline at that position not only is conserved, but that deviation from the consensus could lead to enzymes that are less efficient. Since position 494 is not near the active site of the enzyme, proline may provide stabilization to that specific loop of IspS and hence secondarily enhance the overall kinetic parameters of IspS.

TABLE 7-4 Specific activity of isoprene synthase amino acid variants. Reactions contained 4 mM DMAPP, 50 mM NaCl, 50 mM Tris pH = 8. Reactions were performed at 30° C. S.A. Variant S.A./ Variant (nmol/mg/min) WT S.A. P 950 ± 40 2.0 C 430 ± 10 0.9 N 170 ± 30 0.4 PC 490 ± 20 1.0 SP 770 ± 40 1.6 NS 480 ± 40 1.0 NC 420 ± 30 0.9 SPC 630 ± 40 1.3 WT 480 ± 20 1.0 S 480 ± 20 1.0 SC 440 ± 20 0.9 NP 490 ± 20 1.0 NPC 440 ± 20 0.9 NSP 465 ± 2  1.0 NSC 390 ± 20 0.8 NSPC 502 ± 6  1.1

TABLE 7-5 kcat, KM and Ki for WT, P, SP, and SPC amino acid variants of isoprene synthase. Kcat, KM and Ki were calculated for each trial and then averaged. The reported error is one standard deviation of the three trials that were performed. Variant k_(cat) K_(M) K_(iDMAPP) WT 1.5 ± 0.6 7 ± 4 16 ± 9 P 2.1 ± 0.1 3.6 ± 0.5 13 ± 1 SP 1.2 ± 0.1 4.4 ± 0.3 18 ± 1 SPC 1.5 ± 0.4 3.5 ± 0.8  25 ± 21

Example 8 Expression and Purification of IspS-L494P

Expression of 6×His-Tagged IspS-L494P

N-terminally 6×His-tagged IspS was expressed and purified from strain DW399. The growth procedure is suitable for histidine tagged enzymes expressed in BL21(λDE3)pLysS cells. 10 ml of overnight culture was prepared for each 1 L of planned growth. The appropriate antibiotics (50 ug/ml kanamycin, 50 ug/ml chloramphenicol) were added to 10 ml of LB medium in a 25 ml flask which was inoculated with 1 colony from a fresh plate of cells or directly from glycerol frozen cell stock. Cultures were grown at 30° C. overnight with shaking at ˜220 rpm. Day cultures were prepared in 1 liter of LB medium with appropriate antibiotics for each culture. Each 1 L day culture was inoculated with 10 ml of overnight culture and grown at 30-37° C. with shaking at ˜220 rpm until the OD₆₀₀ reached ˜0.4-0.6. Day cultures were then induced with 400 μM IPTG and allowed to continue growing at 30° C. with shaking at 220 rpm for ˜5-6 hours. Cells were then harvested by centrifugation at 10,000×g for 10 min, 4° C. Following harvest, cells were used directly or stored at −80° C. until ready to process.

Purification of 6×His-Tagged IspS

For purification of histidine tagged enzymes from BL21(λDE3)pLysS cells, cells were gently resuspended in fresh Lysis buffer (Lysis buffer: Ni wash buffer+0.5 mM PMST, 0.01% Tween-20, 1 mg/ml lysozyme, 0.2 mg/ml DNaseI; Ni wash buffer: 50 mM NaH₂PO₄, 300 mM NaCl, 20 mM Imidazole, pH 8.0). Approximately 40-50 ml of lysis buffer was used per 1 L of cell pellet. Cells were then incubated on ice for approximately 30 min. The cell suspension was then lysed fully by passing 2-3 times through a french pressure cell (large french press cell at 1200 psi/High setting) until lysate appeared clear. A sample of the lysate was saved for activity assay and gel analysis (˜100 μl). The lysate was then clarified by centrifuging the lysate at 30,000×g for 30 min, 4° C. in a Sorvall Discovery 90SE ultracentrifuge. The supernatant was removed and retained. A sample of the “clarified lysate” was saved for activity assay and gel analysis (˜100 μl).

The clarified lysate was run over HisTrap HP columns (GE healthcare) using a gradient from 0-100% Ni buffer B. Following loading of the lysate on the column, the column was washed with Ni wash buffer (50 mM NaH₂PO₄, 300 mm NaCl, 20 mM imidazole, ph 8.0). The his-tagged IspS was then eluted from the column using a gradient from 0-100% Ni elution buffer (50 mM NaH₂PO₄, 300 mM NaCl, 500 mM imidazole, ph 8.0) and fractions containing the his-tagged IspS were collected. The column was then washed with Ni stripping buffer (20 mM NaH2PO4, 0.5 m NaCl, 50 mM EDTA, ph 7.4). Samples were then analyzed by SDS-PAGE gel (4-12% gel NUPAGE, Invitrogen) according to manufacturer's directions. Desired fractions were concentrated on spin filters (Vivaspin-20, Sartoris,) and then desalted over a Hi Prep 26/10 Desalting column (GE healthcare) packed with Sephadex G25 resin. The G-25 buffer consisted of 50 mM HEPES, 50 mM NaCl, and 1 mM DTT, pH 7.4. Fractions were then analyzed and concentrated. The samples were then stored at −80° C.

TEV Cleavage (IspS-L494P from Strains DW399)

Strain DW399 is described in Example 6. Digestion was performed with TurboTEV Protease from Eton Bioscience Inc. One unit of TurboTEV per 10 μg of purified protein was used. The digest was performed at 4° C. overnight. Samples were passed through another Ni column equilibrated in the Ni buffer to remove uncleaved enzyme, tag, TurboTEV protease (which is also tagged), and impurities. The Ni column pass though and washes were analyzed using SDS-PAGE gel (NUPAGE, Invitrogen; FIG. 51) and DMAPP activity assays. Samples containing pure enzyme were pooled and desalted into 50 mM NaCl pH 7.4 buffer containing 1 mM DTT and stored at −80° C.

Crystal Structure Determination

The enzyme expressed from strain DW399 was purified as described and a concentrated protein solution was then prepared for surveying possible crystallization conditions. The enzyme was purified independently and surveyed as described below. All in-house crystallization screens were set up using the hanging drop vapor diffusion method. At a minimum, the protein was surveyed using the following commercial screens: the Crystal Screen from Hampton Research (Aliso Viejo, Calif.) and the JCSG+Suite from Qiagen (Valencia, Calif.).

Initial crystallization screens were setup using the Crystal Screen from Hampton Research and the JCSG+Suite from Qiagen. Crystals of the protein derived from DW399 were observed in numerous conditions; optimization included 200 variations of pH, precipitating agents, concentrations, and inhibitors. From the optimization experiments, ten different crystals derived from strain DW399 were screened in-house for diffraction. A crystal composed of IspS-L494P protein was obtained that diffracted to 3.2 Å in house. The large, rod-shaped crystals belong to the tetragonal space group P4₃2₁2, and have unit cell dimensions a=155.8, b=155.8, c=143.7. The crystals were grown by mixing 2 μL of protein (10 mg/ml protein) with 2 μL of precipitant solution [0.02 M MgCl₂, 0.1 M HEPES pH 7.5, 22% (wt/vol) Polyacrylic acid 5100 Na salt] and equilibrated against 500 μL of precipitant. Prior to flash-freezing the crystal in liquid nitrogen, the crystals were cryoprotected by swishing through 0.02 M MgCl₂, 0.1 M HEPES pH 7.5, 22% (wt/vol) Polyacrylic acid 5100 Na salt, and 25% (wt/vol) ethylene glycol.

Data were integrated using Mosflm (Leslie, A. (1998) J. of Appl. Crystallography 30, 1036-1040) and scaled using SCALA (Collaborative Computational Project, N. (1994) Acta Crystallographica Section D 50, 760-763). The data were phased with MOLREP (Vagin, A., and Teplyakov, A. (1997) J. of Appl. Crystallography 30, 1022-1025), using the previously determined structure of IspS from P. alba as the starting model. The crystal contains one dimer in the asymmetric unit with a solvent content of 63%. Data collection and refinement statistics are given in Table 8-1.

Refinement with Refmac5 (Collaborative Computational Project, N. (1994) Acta Crystallographica Section D 50, 760-763) was used with iterative manual rebuilding steps using the visualization program Coot (Emsley, P., and Cowtan, K. (2004) Acta Crystallographica Section D 60, 2126-2132). During refinement, the geometry of the protein was checked using Molprobity (Davis, I. W., et al. (2007) Nucl. Acids Res., 35:W375-W383).

The structure consists of two helical domains, a C-terminal domain containing the active site and N-terminal domain with unknown function. The electron density clearly supports the presence of a proline at position 494 in the enzyme derived from strain DW399 (FIG. 52). Structural alignment of the wild type IspS and IspS-L494P show that the overall fold is unchanged, however the conformation of the loop containing residues 490-497 does vary between the wild type and variant proteins (FIG. 53). Coordinates are provided in Table 8-2.

TABLE 8-1 Data Collection and Refinement Statistics for IspS-L494P Data Collection Space Group P4₃2₁2 Cell dimensions A, b, c (Å) 155.8, 155.8, 143.6 α, β, γ, (°) 90.0, 90.0, 90.0 Resolution (Å) 25.7-3.20 R_(merge)  16.6 (40.5)^(a) <I/σI> 5.7 (2.1) Completeness (%) 98.8 (95.1) Redundancy 3.4 (2.4) Refinement Resolution (Å) 25.7-3.20 No. measured reflections 99059 No. Unique reflections 27845 R_(work) 23.5 R_(free) 28.6 rmsd bonds, (Å) 0.005 rmsd angles, (°) 0.756 No. of Atoms Protein 8654 Water 4 ^(a)Values in parenthesis refer to highest resolution shell.

TABLE 8-2 Coordinates for L494P Structure ATOM 1 N ALA A 7 58.967 −33.368 −28.452 1.00 32.46 A N ATOM 2 CA ALA A 7 60.455 −33.320 −28.515 1.00 32.33 A C ATOM 4 CB ALA A 7 60.968 −34.329 −29.538 1.00 32.27 A C ATOM 8 C ALA A 7 60.928 −31.913 −28.869 1.00 32.20 A C ATOM 9 O ALA A 7 61.175 −31.618 −30.038 1.00 31.89 A O ATOM 13 N ASN A 8 61.056 −31.054 −27.855 1.00 32.28 A N ATOM 14 CA ASN A 8 61.414 −29.646 −28.067 1.00 32.54 A C ATOM 16 CB ASN A 8 60.171 −28.754 −27.938 1.00 32.84 A C ATOM 19 CG ASN A 8 60.193 −27.562 −28.897 1.00 33.76 A C ATOM 20 OD1 ASN A 8 61.242 −26.964 −29.150 1.00 34.16 A O ATOM 21 ND2 ASN A 8 59.027 −27.215 −29.432 1.00 34.29 A N ATOM 24 C ASN A 8 62.519 −29.158 −27.125 1.00 32.38 A C ATOM 25 O ASN A 8 62.774 −29.764 −26.081 1.00 31.88 A O ATOM 27 N TYR A 9 63.148 −28.045 −27.510 1.00 32.53 A N ATOM 28 CA TYR A 9 64.378 −27.551 −26.881 1.00 32.48 A C ATOM 30 CB TYR A 9 65.529 −27.650 −27.886 1.00 32.17 A C ATOM 33 CG TYR A 9 65.491 −28.904 −28.713 1.00 31.92 A C ATOM 34 CD1 TYR A 9 65.999 −30.097 −28.214 1.00 32.88 A C ATOM 36 CE1 TYR A 9 65.963 −31.258 −28.964 1.00 32.64 A C ATOM 38 CZ TYR A 9 65.409 −31.241 −30.230 1.00 32.19 A C ATOM 39 OH TYR A 9 65.370 −32.394 −30.978 1.00 31.19 A O ATOM 41 CE2 TYR A 9 64.892 −30.067 −30.748 1.00 31.99 A C ATOM 43 CD2 TYR A 9 64.933 −28.906 −29.987 1.00 31.30 A C ATOM 45 C TYR A 9 64.297 −26.100 −26.401 1.00 32.65 A C ATOM 46 O TYR A 9 65.333 −25.490 −26.119 1.00 32.90 A O ATOM 48 N GLU A 10 63.089 −25.547 −26.304 1.00 32.35 A N ATOM 49 CA GLU A 10 62.923 −24.126 −25.971 1.00 32.21 A C ATOM 51 CB GLU A 10 61.450 −23.711 −26.089 1.00 32.51 A C ATOM 54 CG GLU A 10 60.880 −23.803 −27.509 1.00 34.11 A C ATOM 57 CD GLU A 10 61.671 −23.001 −28.542 1.00 35.77 A C ATOM 58 OE1 GLU A 10 62.114 −21.874 −28.223 1.00 35.78 A O ATOM 59 OE2 GLU A 10 61.841 −23.503 −29.677 1.00 35.44 A O ATOM 60 C GLU A 10 63.473 −23.814 −24.572 1.00 31.42 A C ATOM 61 O GLU A 10 63.467 −24.684 −23.700 1.00 31.43 A O ATOM 63 N PRO A 11 63.953 −22.572 −24.359 1.00 30.52 A N ATOM 64 CA PRO A 11 64.709 −22.252 −23.148 1.00 30.13 A C ATOM 66 CB PRO A 11 65.263 −20.857 −23.449 1.00 30.16 A C ATOM 69 CG PRO A 11 64.250 −20.247 −24.336 1.00 30.10 A C ATOM 72 CD PRO A 11 63.722 −21.372 −25.186 1.00 30.45 A C ATOM 75 C PRO A 11 63.856 −22.208 −21.886 1.00 29.77 A C ATOM 76 O PRO A 11 62.763 −21.645 −21.902 1.00 30.21 A O ATOM 77 N ASN A 12 64.357 −22.802 −20.807 1.00 29.24 A N ATOM 78 CA ASN A 12 63.717 −22.692 −19.501 1.00 28.99 A C ATOM 80 CB ASN A 12 64.148 −23.841 −18.588 1.00 28.99 A C ATOM 83 CG ASN A 12 63.744 −25.201 −19.128 1.00 28.62 A C ATOM 84 OD1 ASN A 12 62.558 −25.498 −19.268 1.00 29.36 A O ATOM 85 ND2 ASN A 12 64.731 −26.038 −19.423 1.00 27.55 A N ATOM 88 C ASN A 12 64.083 −21.348 −18.872 1.00 28.99 A C ATOM 89 O ASN A 12 65.197 −20.853 −19.062 1.00 29.27 A O ATOM 91 N SER A 13 63.146 −20.760 −18.131 1.00 28.65 A N ATOM 92 CA SER A 13 63.365 −19.461 −17.482 1.00 28.22 A C ATOM 94 CB SER A 13 62.052 −18.933 −16.893 1.00 28.27 A C ATOM 97 OG SER A 13 61.433 −19.905 −16.067 1.00 27.86 A O ATOM 99 C SER A 13 64.437 −19.531 −16.388 1.00 27.86 A C ATOM 100 O SER A 13 65.127 −18.545 −16.117 1.00 27.35 A O ATOM 102 N TRP A 14 64.573 −20.704 −15.775 1.00 27.59 A N ATOM 103 CA TRP A 14 65.538 −20.919 −14.697 1.00 27.37 A C ATOM 105 CB TRP A 14 64.967 −21.893 −13.649 1.00 27.41 A C ATOM 108 CG TRP A 14 64.246 −23.092 −14.212 1.00 28.21 A C ATOM 109 CD1 TRP A 14 62.894 −23.246 −14.346 1.00 29.22 A C ATOM 111 NE1 TRP A 14 62.607 −24.471 −14.897 1.00 29.08 A N ATOM 113 CE2 TRP A 14 63.781 −25.138 −15.127 1.00 29.46 A C ATOM 114 CD2 TRP A 14 64.836 −24.299 −14.706 1.00 28.64 A C ATOM 115 CE3 TRP A 14 66.153 −24.754 −14.836 1.00 29.12 A C ATOM 117 CZ3 TRP A 14 66.373 −26.014 −15.377 1.00 30.29 A C ATOM 119 CH2 TRP A 14 65.303 −26.825 −15.788 1.00 30.52 A C ATOM 121 CZ2 TRP A 14 64.004 −26.406 −15.670 1.00 30.11 A C ATOM 123 C TRP A 14 66.912 −21.401 −15.189 1.00 27.25 A C ATOM 124 O TRP A 14 67.776 −21.723 −14.378 1.00 27.30 A O ATOM 126 N ASP A 15 67.127 −21.435 −16.503 1.00 27.11 A N ATOM 127 CA ASP A 15 68.419 −21.859 −17.055 1.00 27.19 A C ATOM 129 CB ASP A 15 68.371 −21.911 −18.587 1.00 27.21 A C ATOM 132 CG ASP A 15 67.685 −23.157 −19.117 1.00 27.43 A C ATOM 133 OD1 ASP A 15 67.686 −24.200 −18.426 1.00 26.27 A O ATOM 134 OD2 ASP A 15 67.154 −23.094 −20.246 1.00 29.06 A O ATOM 135 C ASP A 15 69.562 −20.941 −16.625 1.00 27.45 A C ATOM 136 O ASP A 15 69.347 −19.773 −16.302 1.00 27.69 A O ATOM 138 N TYR A 16 70.778 −21.479 −16.633 1.00 27.65 A N ATOM 139 CA TYR A 16 71.968 −20.698 −16.299 1.00 27.87 A C ATOM 141 CB TYR A 16 73.122 −21.618 −15.890 1.00 27.97 A C ATOM 144 CG TYR A 16 72.878 −22.322 −14.569 1.00 28.42 A C ATOM 145 CD1 TYR A 16 72.806 −21.601 −13.378 1.00 28.17 A C ATOM 147 CE1 TYR A 16 72.576 −22.236 −12.164 1.00 26.82 A C ATOM 149 CZ TYR A 16 72.417 −23.606 −12.130 1.00 26.17 A C ATOM 150 OH TYR A 16 72.191 −24.230 −10.929 1.00 25.22 A O ATOM 152 CE2 TYR A 16 72.485 −24.348 −13.296 1.00 26.88 A C ATOM 154 CD2 TYR A 16 72.715 −23.704 −14.509 1.00 27.97 A C ATOM 156 C TYR A 16 72.389 −19.774 −17.445 1.00 28.24 A C ATOM 157 O TYR A 16 73.125 −18.814 −17.225 1.00 28.23 A O ATOM 159 N ASP A 17 71.929 −20.071 −18.660 1.00 28.81 A N ATOM 160 CA ASP A 17 72.109 −19.171 −19.806 1.00 29.05 A C ATOM 162 CB ASP A 17 71.891 −19.919 −21.129 1.00 28.88 A C ATOM 165 CG ASP A 17 72.965 −20.962 −21.406 1.00 28.36 A C ATOM 166 OD1 ASP A 17 74.154 −20.593 −21.514 1.00 27.28 A O ATOM 167 OD2 ASP A 17 72.614 −22.154 −21.539 1.00 27.24 A O ATOM 168 C ASP A 17 71.140 −17.987 −19.726 1.00 29.57 A C ATOM 169 O ASP A 17 71.501 −16.858 −20.062 1.00 29.32 A O ATOM 171 N TYR A 18 69.916 −18.260 −19.274 1.00 30.37 A N ATOM 172 CA TYR A 18 68.828 −17.278 −19.250 1.00 31.29 A C ATOM 174 CB TYR A 18 67.495 −18.008 −19.056 1.00 31.77 A C ATOM 177 CG TYR A 18 66.249 −17.171 −19.266 1.00 35.14 A C ATOM 178 CD1 TYR A 18 65.523 −17.255 −20.456 1.00 37.79 A C ATOM 180 CE1 TYR A 18 64.370 −16.503 −20.650 1.00 38.22 A C ATOM 182 CZ TYR A 18 63.926 −15.661 −19.645 1.00 38.92 A C ATOM 183 OH TYR A 18 62.785 −14.918 −19.837 1.00 40.58 A O ATOM 185 CE2 TYR A 18 64.623 −15.565 −18.451 1.00 38.20 A C ATOM 187 CD2 TYR A 18 65.775 −16.321 −18.265 1.00 36.98 A C ATOM 189 C TYR A 18 69.043 −16.237 −18.149 1.00 31.48 A C ATOM 190 O TYR A 18 69.094 −15.039 −18.426 1.00 31.70 A O ATOM 192 N LEU A 19 69.156 −16.699 −16.905 1.00 31.72 A N ATOM 193 CA LEU A 19 69.585 −15.852 −15.792 1.00 31.90 A C ATOM 195 CB LEU A 19 69.089 −16.416 −14.455 1.00 31.77 A C ATOM 198 CG LEU A 19 67.574 −16.531 −14.261 1.00 32.74 A C ATOM 200 CD1 LEU A 19 67.248 −17.518 −13.141 1.00 32.00 A C ATOM 204 CD2 LEU A 19 66.943 −15.164 −13.989 1.00 31.72 A C ATOM 208 C LEU A 19 71.106 −15.825 −15.806 1.00 32.37 A C ATOM 209 O LEU A 19 71.727 −16.380 −16.712 1.00 32.67 A O ATOM 211 N LEU A 20 71.709 −15.174 −14.815 1.00 32.83 A N ATOM 212 CA LEU A 20 73.148 −15.281 −14.594 1.00 33.25 A C ATOM 214 CB LEU A 20 73.466 −16.668 −14.021 1.00 33.14 A C ATOM 217 CG LEU A 20 74.826 −16.886 −13.356 1.00 33.70 A C ATOM 219 CD1 LEU A 20 74.988 −15.984 −12.139 1.00 34.63 A C ATOM 223 CD2 LEU A 20 74.985 −18.351 −12.969 1.00 33.93 A C ATOM 227 C LEU A 20 73.947 −15.025 −15.880 1.00 33.88 A C ATOM 228 O LEU A 20 74.771 −15.848 −16.292 1.00 33.76 A O ATOM 230 N SER A 21 73.677 −13.888 −16.519 1.00 34.62 A N ATOM 231 CA SER A 21 74.409 −13.467 −17.718 1.00 35.00 A C ATOM 233 CB SER A 21 73.478 −13.378 −18.933 1.00 35.02 A C ATOM 236 OG SER A 21 73.457 −14.605 −19.644 1.00 34.89 A O ATOM 238 C SER A 21 75.117 −12.136 −17.488 1.00 35.34 A C ATOM 239 O SER A 21 74.711 −11.334 −16.639 1.00 34.98 A O ATOM 241 N SER A 22 76.173 −11.913 −18.266 1.00 35.95 A N ATOM 242 CA SER A 22 77.087 −10.795 −18.048 1.00 36.40 A C ATOM 244 CB SER A 22 78.430 −11.076 −18.732 1.00 36.31 A C ATOM 247 OG SER A 22 78.248 −11.367 −20.107 1.00 35.88 A O ATOM 249 C SER A 22 76.530 −9.461 −18.543 1.00 36.86 A C ATOM 250 O SER A 22 76.493 −9.205 −19.751 1.00 36.97 A O ATOM 252 N ASP A 23 76.099 −8.619 −17.603 1.00 37.22 A N ATOM 253 CA ASP A 23 75.752 −7.232 −17.906 1.00 37.43 A C ATOM 255 CB ASP A 23 75.077 −6.567 −16.694 1.00 37.44 A C ATOM 258 CG ASP A 23 74.428 −5.228 −17.030 1.00 37.60 A C ATOM 259 OD1 ASP A 23 74.332 −4.869 −18.223 1.00 37.88 A O ATOM 260 OD2 ASP A 23 74.003 −4.531 −16.084 1.00 37.64 A O ATOM 261 C ASP A 23 77.049 −6.517 −18.299 1.00 37.55 A C ATOM 262 O ASP A 23 77.168 −5.993 −19.410 1.00 37.66 A O ATOM 264 N THR A 24 78.015 −6.509 −17.380 1.00 37.50 A N ATOM 265 CA THR A 24 79.413 −6.192 −17.700 1.00 37.32 A C ATOM 267 CB THR A 24 79.691 −4.665 −17.661 1.00 37.41 A C ATOM 269 OG1 THR A 24 78.608 −3.952 −18.274 1.00 37.33 A O ATOM 271 CG2 THR A 24 80.991 −4.330 −18.392 1.00 36.82 A C ATOM 275 C THR A 24 80.360 −6.925 −16.730 1.00 37.05 A C ATOM 276 O THR A 24 81.444 −6.430 −16.407 1.00 37.13 A O ATOM 278 N ASP A 25 79.944 −8.116 −16.290 1.00 36.41 A N ATOM 279 CA ASP A 25 80.665 −8.890 −15.278 1.00 35.69 A C ATOM 281 CB ASP A 25 79.714 −9.307 −14.149 1.00 35.42 A C ATOM 284 CG ASP A 25 79.022 −8.123 −13.489 1.00 34.28 A C ATOM 285 OD1 ASP A 25 79.536 −6.988 −13.575 1.00 31.33 A O ATOM 286 OD2 ASP A 25 77.956 −8.335 −12.875 1.00 33.31 A O ATOM 287 C ASP A 25 81.298 −10.136 −15.899 1.00 35.33 A C ATOM 288 O ASP A 25 80.594 −11.077 −16.273 1.00 35.35 A O ATOM 290 N GLU A 26 82.625 −10.134 −16.002 1.00 34.79 A N ATOM 291 CA GLU A 26 83.372 −11.273 −16.546 1.00 34.55 A C ATOM 293 CB GLU A 26 84.858 −10.920 −16.690 1.00 34.43 A C ATOM 296 CG GLU A 26 85.159 −9.814 −17.695 1.00 33.53 A C ATOM 299 CD GLU A 26 86.645 −9.516 −17.821 1.00 31.34 A C ATOM 300 OE1 GLU A 26 87.432 −9.968 −16.962 1.00 30.11 A O ATOM 301 OE2 GLU A 26 87.026 −8.822 −18.785 1.00 29.48 A O ATOM 302 C GLU A 26 83.251 −12.515 −15.662 1.00 34.62 A C ATOM 303 O GLU A 26 83.213 −13.644 −16.159 1.00 34.51 A O ATOM 305 N SER A 27 83.197 −12.292 −14.351 1.00 34.63 A N ATOM 306 CA SER A 27 83.188 −13.374 −13.365 1.00 34.68 A C ATOM 308 CB SER A 27 83.367 −12.794 −11.957 1.00 34.79 A C ATOM 311 OG SER A 27 82.483 −11.706 −11.735 1.00 34.93 A O ATOM 313 C SER A 27 81.930 −14.252 −13.416 1.00 34.53 A C ATOM 314 O SER A 27 81.963 −15.407 −12.979 1.00 34.27 A O ATOM 316 N ILE A 28 80.831 −13.709 −13.942 1.00 34.31 A N ATOM 317 CA ILE A 28 79.602 −14.484 −14.119 1.00 34.09 A C ATOM 319 CB ILE A 28 78.412 −13.598 −14.561 1.00 34.14 A C ATOM 321 CG1 ILE A 28 78.065 −12.575 −13.476 1.00 34.77 A C ATOM 324 CD1 ILE A 28 76.877 −11.689 −13.824 1.00 35.54 A C ATOM 328 CG2 ILE A 28 77.190 −14.457 −14.860 1.00 33.66 A C ATOM 332 C ILE A 28 79.798 −15.599 −15.148 1.00 33.79 A C ATOM 333 O ILE A 28 79.289 −16.700 −14.968 1.00 33.59 A O ATOM 335 N GLU A 29 80.552 −15.315 −16.210 1.00 33.59 A N ATOM 336 CA GLU A 29 80.739 −16.270 −17.313 1.00 33.41 A C ATOM 338 CB GLU A 29 81.273 −15.556 −18.564 1.00 33.57 A C ATOM 341 CG GLU A 29 80.268 −14.599 −19.206 1.00 34.79 A C ATOM 344 CD GLU A 29 78.994 −15.293 −19.675 1.00 35.14 A C ATOM 345 OE1 GLU A 29 79.092 −16.335 −20.357 1.00 35.06 A O ATOM 346 OE2 GLU A 29 77.892 −14.792 −19.362 1.00 35.70 A O ATOM 347 C GLU A 29 81.627 −17.476 −16.984 1.00 32.74 A C ATOM 348 O GLU A 29 81.700 −18.415 −17.776 1.00 32.85 A O ATOM 350 N VAL A 30 82.309 −17.449 −15.840 1.00 31.82 A N ATOM 351 CA VAL A 30 82.990 −18.640 −15.320 1.00 30.90 A C ATOM 353 CB VAL A 30 84.379 −18.305 −14.736 1.00 30.95 A C ATOM 355 CG1 VAL A 30 85.158 −19.583 −14.445 1.00 30.39 A C ATOM 359 CG2 VAL A 30 85.160 −17.412 −15.693 1.00 30.85 A C ATOM 363 C VAL A 30 82.117 −19.310 −14.253 1.00 29.93 A C ATOM 364 O VAL A 30 82.088 −20.533 −14.149 1.00 29.30 A O ATOM 366 N TYR A 31 81.419 −18.492 −13.468 1.00 29.33 A N ATOM 367 CA TYR A 31 80.412 −18.952 −12.504 1.00 28.99 A C ATOM 369 CB TYR A 31 79.844 −17.729 −11.762 1.00 29.11 A C ATOM 372 CG TYR A 31 78.990 −18.015 −10.541 1.00 29.97 A C ATOM 373 CD1 TYR A 31 79.552 −18.524 −9.371 1.00 30.42 A C ATOM 375 CE1 TYR A 31 78.767 −18.768 −8.241 1.00 31.07 A C ATOM 377 CZ TYR A 31 77.406 −18.490 −8.274 1.00 31.23 A C ATOM 378 OH TYR A 31 76.621 −18.728 −7.165 1.00 30.48 A O ATOM 380 CE2 TYR A 31 76.829 −17.972 −9.420 1.00 30.59 A C ATOM 382 CD2 TYR A 31 77.623 −17.731 −10.542 1.00 31.01 A C ATOM 384 C TYR A 31 79.294 −19.726 −13.225 1.00 28.35 A C ATOM 385 O TYR A 31 78.896 −20.815 −12.802 1.00 28.24 A O ATOM 387 N LYS A 32 78.811 −19.143 −14.321 1.00 27.54 A N ATOM 388 CA LYS A 32 77.792 −19.738 −15.196 1.00 26.68 A C ATOM 390 CB LYS A 32 77.434 −18.724 −16.292 1.00 27.16 A C ATOM 393 CG LYS A 32 76.586 −19.211 −17.469 1.00 27.92 A C ATOM 396 CD LYS A 32 76.980 −18.446 −18.748 1.00 29.61 A C ATOM 399 CE LYS A 32 75.811 −18.227 −19.693 1.00 30.33 A C ATOM 402 NZ LYS A 32 74.948 −17.083 −19.266 1.00 30.04 A N ATOM 406 C LYS A 32 78.285 −21.036 −15.826 1.00 25.58 A C ATOM 407 O LYS A 32 77.620 −22.067 −15.728 1.00 25.63 A O ATOM 409 N ASP A 33 79.448 −20.974 −16.475 1.00 24.33 A N ATOM 410 CA ASP A 33 80.056 −22.154 −17.106 1.00 23.26 A C ATOM 412 CB ASP A 33 81.367 −21.783 −17.822 1.00 23.36 A C ATOM 415 CG ASP A 33 81.142 −21.100 −19.173 1.00 23.27 A C ATOM 416 OD1 ASP A 33 79.992 −21.051 −19.659 1.00 23.99 A O ATOM 417 OD2 ASP A 33 82.133 −20.612 −19.757 1.00 21.23 A O ATOM 418 C ASP A 33 80.313 −23.278 −16.099 1.00 22.17 A C ATOM 419 O ASP A 33 80.256 −24.455 −16.454 1.00 21.98 A O ATOM 421 N LYS A 34 80.592 −22.910 −14.849 1.00 21.18 A N ATOM 422 CA LYS A 34 80.789 −23.885 −13.774 1.00 20.15 A C ATOM 424 CB LYS A 34 81.420 −23.221 −12.541 1.00 19.97 A C ATOM 427 CG LYS A 34 82.264 −24.155 −11.679 1.00 19.67 A C ATOM 430 CD LYS A 34 83.466 −23.426 −11.061 1.00 20.43 A C ATOM 433 CE LYS A 34 84.646 −24.371 −10.818 1.00 20.70 A C ATOM 436 NZ LYS A 34 85.942 −23.644 −10.709 1.00 17.82 A N ATOM 440 C LYS A 34 79.457 −24.534 −13.409 1.00 19.43 A C ATOM 441 O LYS A 34 79.368 −25.759 −13.320 1.00 20.13 A O ATOM 443 N ALA A 35 78.427 −23.712 −13.209 1.00 17.92 A N ATOM 444 CA ALA A 35 77.080 −24.211 −12.927 1.00 16.84 A C ATOM 446 CB ALA A 35 76.086 −23.063 −12.871 1.00 16.71 A C ATOM 450 C ALA A 35 76.656 −25.222 −13.984 1.00 16.12 A C ATOM 451 O ALA A 35 76.317 −26.360 −13.663 1.00 15.55 A O ATOM 453 N LYS A 36 76.703 −24.798 −15.245 1.00 15.82 A N ATOM 454 CA LYS A 36 76.337 −25.647 −16.385 1.00 15.48 A C ATOM 456 CB LYS A 36 76.637 −24.921 −17.708 1.00 15.46 A C ATOM 459 CG LYS A 36 75.690 −23.752 −18.007 1.00 14.99 A C ATOM 462 CD LYS A 36 76.314 −22.686 −18.917 1.00 13.95 A C ATOM 465 CE LYS A 36 76.428 −23.143 −20.367 1.00 13.77 A C ATOM 468 NZ LYS A 36 76.844 −22.031 −21.277 1.00 12.18 A N ATOM 472 C LYS A 36 77.038 −27.011 −16.359 1.00 15.21 A C ATOM 473 O LYS A 36 76.413 −28.030 −16.650 1.00 15.02 A O ATOM 475 N LYS A 37 78.324 −27.024 −16.004 1.00 15.15 A N ATOM 476 CA LYS A 37 79.104 −28.267 −15.941 1.00 15.11 A C ATOM 478 CB LYS A 37 80.602 −27.970 −15.781 1.00 15.02 A C ATOM 481 CG LYS A 37 81.457 −29.221 −15.544 1.00 16.38 A C ATOM 484 CD LYS A 37 82.922 −29.033 −15.934 1.00 16.66 A C ATOM 487 CE LYS A 37 83.714 −30.321 −15.703 1.00 15.63 A C ATOM 490 NZ LYS A 37 85.058 −30.304 −16.342 1.00 14.75 A N ATOM 494 C LYS A 37 78.626 −29.187 −14.813 1.00 15.19 A C ATOM 495 O LYS A 37 78.467 −30.397 −15.011 1.00 15.35 A O ATOM 497 N LEU A 38 78.405 −28.612 −13.633 1.00 14.82 A N ATOM 498 CA LEU A 38 77.904 −29.372 −12.488 1.00 14.29 A C ATOM 500 CB LEU A 38 77.978 −28.533 −11.208 1.00 14.07 A C ATOM 503 CG LEU A 38 79.356 −28.035 −10.767 1.00 13.08 A C ATOM 505 CD1 LEU A 38 79.227 −27.212 −9.494 1.00 10.42 A C ATOM 509 CD2 LEU A 38 80.325 −29.193 −10.568 1.00 12.91 A C ATOM 513 C LEU A 38 76.463 −29.837 −12.717 1.00 14.27 A C ATOM 514 O LEU A 38 76.094 −30.948 −12.336 1.00 14.74 A O ATOM 516 N GLU A 39 75.656 −28.979 −13.339 1.00 13.96 A N ATOM 517 CA GLU A 39 74.263 −29.296 −13.651 1.00 13.65 A C ATOM 519 CB GLU A 39 73.599 −28.108 −14.354 1.00 13.97 A C ATOM 522 CG GLU A 39 72.085 −28.233 −14.528 1.00 14.95 A C ATOM 525 CD GLU A 39 71.485 −27.097 −15.345 1.00 16.13 A C ATOM 526 OE1 GLU A 39 72.200 −26.522 −16.200 1.00 15.33 A O ATOM 527 OE2 GLU A 39 70.291 −26.787 −15.136 1.00 15.50 A O ATOM 528 C GLU A 39 74.160 −30.536 −14.534 1.00 13.24 A C ATOM 529 O GLU A 39 73.290 −31.379 −14.327 1.00 13.19 A O ATOM 531 N ALA A 40 75.050 −30.635 −15.517 1.00 13.18 A N ATOM 532 CA ALA A 40 75.078 −31.773 −16.434 1.00 13.27 A C ATOM 534 CB ALA A 40 76.121 −31.545 −17.518 1.00 13.09 A C ATOM 538 C ALA A 40 75.372 −33.075 −15.694 1.00 13.60 A C ATOM 539 O ALA A 40 74.631 −34.052 −15.815 1.00 13.20 A O ATOM 541 N GLU A 41 76.459 −33.071 −14.926 1.00 14.01 A N ATOM 542 CA GLU A 41 76.892 −34.243 −14.162 1.00 13.91 A C ATOM 544 CB GLU A 41 78.136 −33.902 −13.331 1.00 14.03 A C ATOM 547 CG GLU A 41 78.963 −35.108 −12.883 1.00 14.30 A C ATOM 550 CD GLU A 41 80.385 −34.740 −12.450 1.00 14.59 A C ATOM 551 OE1 GLU A 41 80.750 −33.545 −12.486 1.00 13.71 A O ATOM 552 OE2 GLU A 41 81.147 −35.655 −12.077 1.00 16.03 A O ATOM 553 C GLU A 41 75.766 −34.772 −13.268 1.00 13.65 A C ATOM 554 O GLU A 41 75.536 −35.976 −13.210 1.00 13.97 A O ATOM 556 N VAL A 42 75.058 −33.872 −12.592 1.00 13.32 A N ATOM 557 CA VAL A 42 73.908 −34.261 −11.772 1.00 13.82 A C ATOM 559 CB VAL A 42 73.337 −33.065 −10.980 1.00 13.98 A C ATOM 561 CG1 VAL A 42 72.097 −33.481 −10.190 1.00 11.81 A C ATOM 565 CG2 VAL A 42 74.399 −32.489 −10.054 1.00 14.38 A C ATOM 569 C VAL A 42 72.795 −34.852 −12.638 1.00 14.41 A C ATOM 570 O VAL A 42 72.145 −35.826 −12.252 1.00 14.02 A O ATOM 572 N ARG A 43 72.581 −34.250 −13.806 1.00 15.17 A N ATOM 573 CA ARG A 43 71.602 −34.748 −14.771 1.00 15.29 A C ATOM 575 CB ARG A 43 71.509 −33.805 −15.980 1.00 15.11 A C ATOM 578 CG ARG A 43 70.642 −34.310 −17.123 1.00 15.92 A C ATOM 581 CD ARG A 43 71.411 −35.191 −18.114 1.00 15.67 A C ATOM 584 NE ARG A 43 70.592 −35.551 −19.270 1.00 16.12 A N ATOM 586 CZ ARG A 43 70.913 −36.472 −20.177 1.00 16.78 A C ATOM 587 NH1 ARG A 43 70.082 −36.721 −21.183 1.00 17.28 A N ATOM 590 NH2 ARG A 43 72.053 −37.151 −20.093 1.00 17.42 A N ATOM 593 C ARG A 43 71.965 −36.162 −15.216 1.00 15.15 A C ATOM 594 O ARG A 43 71.100 −37.037 −15.276 1.00 15.51 A O ATOM 596 N ARG A 44 73.241 −36.374 −15.531 1.00 14.58 A N ATOM 597 CA ARG A 44 73.725 −37.680 −15.973 1.00 14.27 A C ATOM 599 CB ARG A 44 75.239 −37.638 −16.204 1.00 14.13 A C ATOM 602 CG ARG A 44 75.837 −38.956 −16.685 1.00 13.74 A C ATOM 605 CD ARG A 44 77.311 −38.822 −17.038 1.00 12.58 A C ATOM 608 NE ARG A 44 78.167 −38.729 −15.858 1.00 10.73 A N ATOM 610 CZ ARG A 44 79.495 −38.644 −15.897 1.00 10.52 A C ATOM 611 NH1 ARG A 44 80.187 −38.566 −14.766 1.00 10.42 A N ATOM 614 NH2 ARG A 44 80.139 −38.638 −17.061 1.00 11.08 A N ATOM 617 C ARG A 44 73.391 −38.772 −14.963 1.00 14.55 A C ATOM 618 O ARG A 44 72.868 −39.825 −15.327 1.00 14.69 A O ATOM 620 N GLU A 45 73.690 −38.506 −13.694 1.00 14.88 A N ATOM 621 CA GLU A 45 73.533 −39.502 −12.633 1.00 15.12 A C ATOM 623 CB GLU A 45 74.228 −39.032 −11.351 1.00 15.38 A C ATOM 626 CG GLU A 45 75.737 −38.939 −11.473 1.00 15.34 A C ATOM 629 CD GLU A 45 76.367 −40.280 −11.758 1.00 15.55 A C ATOM 630 OE1 GLU A 45 76.236 −41.183 −10.906 1.00 16.23 A O ATOM 631 OE2 GLU A 45 76.982 −40.433 −12.835 1.00 15.50 A O ATOM 632 C GLU A 45 72.074 −39.843 −12.337 1.00 15.09 A C ATOM 633 O GLU A 45 71.771 −40.973 −11.951 1.00 15.45 A O ATOM 635 N ILE A 46 71.180 −38.870 −12.506 1.00 14.76 A N ATOM 636 CA ILE A 46 69.744 −39.112 −12.348 1.00 14.30 A C ATOM 638 CB ILE A 46 68.926 −37.795 −12.366 1.00 14.11 A C ATOM 640 CG1 ILE A 46 69.239 −36.947 −11.130 1.00 13.91 A C ATOM 643 CD1 ILE A 46 68.714 −35.524 −11.210 1.00 11.51 A C ATOM 647 CG2 ILE A 46 67.439 −38.092 −12.399 1.00 13.21 A C ATOM 651 C ILE A 46 69.232 −40.051 −13.446 1.00 14.04 A C ATOM 652 O ILE A 46 68.418 −40.939 −13.175 1.00 13.88 A O ATOM 654 N ASN A 47 69.725 −39.856 −14.671 1.00 13.76 A N ATOM 655 CA ASN A 47 69.287 −40.643 −15.834 1.00 13.67 A C ATOM 657 CB ASN A 47 69.461 −39.835 −17.124 1.00 13.22 A C ATOM 660 CG ASN A 47 68.546 −38.636 −17.190 1.00 12.47 A C ATOM 661 OD1 ASN A 47 67.387 −38.694 −16.774 1.00 12.16 A O ATOM 662 ND2 ASN A 47 69.058 −37.539 −17.722 1.00 13.14 A N ATOM 665 C ASN A 47 69.994 −41.987 −15.994 1.00 13.91 A C ATOM 666 O ASN A 47 69.587 −42.808 −16.817 1.00 13.86 A O ATOM 668 N ASN A 48 71.048 −42.205 −15.213 1.00 14.42 A N ATOM 669 CA ASN A 48 71.827 −43.441 −15.274 1.00 14.74 A C ATOM 671 CB ASN A 48 72.850 −43.469 −14.132 1.00 14.72 A C ATOM 674 CG ASN A 48 73.753 −44.679 −14.183 1.00 13.04 A C ATOM 675 OD1 ASN A 48 74.135 −45.138 −15.256 1.00 11.75 A O ATOM 676 ND2 ASN A 48 74.106 −45.199 −13.017 1.00 13.70 A N ATOM 679 C ASN A 48 70.947 −44.693 −15.222 1.00 15.25 A C ATOM 680 O ASN A 48 70.371 −45.016 −14.186 1.00 14.91 A O ATOM 682 N GLU A 49 70.855 −45.385 −16.355 1.00 16.44 A N ATOM 683 CA GLU A 49 70.070 −46.615 −16.472 1.00 17.44 A C ATOM 685 CB GLU A 49 70.073 −47.113 −17.924 1.00 17.86 A C ATOM 688 CG GLU A 49 69.434 −46.153 −18.947 1.00 20.47 A C ATOM 691 CD GLU A 49 67.909 −46.256 −19.022 1.00 23.90 A C ATOM 692 OE1 GLU A 49 67.362 −47.364 −18.830 1.00 26.25 A O ATOM 693 OE2 GLU A 49 67.256 −45.223 −19.293 1.00 24.41 A O ATOM 694 C GLU A 49 70.608 −47.715 −15.555 1.00 17.76 A C ATOM 695 O GLU A 49 69.839 −48.490 −14.995 1.00 17.28 A O ATOM 697 N LYS A 50 71.929 −47.765 −15.402 1.00 18.95 A N ATOM 698 CA LYS A 50 72.596 −48.784 −14.591 1.00 19.93 A C ATOM 700 CB LYS A 50 73.871 −49.267 −15.298 1.00 20.28 A C ATOM 703 CG LYS A 50 73.695 −49.676 −16.758 1.00 21.77 A C ATOM 706 CD LYS A 50 74.932 −50.420 −17.276 1.00 23.08 A C ATOM 709 CE LYS A 50 75.158 −50.200 −18.772 1.00 23.59 A C ATOM 712 NZ LYS A 50 73.974 −50.577 −19.593 1.00 23.30 A N ATOM 716 C LYS A 50 72.955 −48.250 −13.200 1.00 20.51 A C ATOM 717 O LYS A 50 74.120 −48.286 −12.796 1.00 20.59 A O ATOM 719 N ALA A 51 71.958 −47.758 −12.470 1.00 21.42 A N ATOM 720 CA ALA A 51 72.171 −47.241 −11.116 1.00 22.31 A C ATOM 722 CB ALA A 51 71.607 −45.839 −10.994 1.00 22.41 A C ATOM 726 C ALA A 51 71.525 −48.163 −10.085 1.00 23.21 A C ATOM 727 O ALA A 51 70.500 −48.791 −10.361 1.00 23.63 A O ATOM 729 N GLU A 52 72.124 −48.239 −8.898 1.00 23.78 A N ATOM 730 CA GLU A 52 71.577 −49.056 −7.816 1.00 24.30 A C ATOM 732 CB GLU A 52 72.590 −49.208 −6.675 1.00 24.41 A C ATOM 735 CG GLU A 52 72.493 −50.535 −5.927 1.00 26.16 A C ATOM 738 CD GLU A 52 72.854 −51.746 −6.787 1.00 27.22 A C ATOM 739 OE1 GLU A 52 73.411 −51.571 −7.894 1.00 27.13 A O ATOM 740 OE2 GLU A 52 72.580 −52.881 −6.345 1.00 28.02 A O ATOM 741 C GLU A 52 70.296 −48.394 −7.320 1.00 24.56 A C ATOM 742 O GLU A 52 70.241 −47.171 −7.194 1.00 25.07 A O ATOM 744 N PHE A 53 69.272 −49.199 −7.049 1.00 24.66 A N ATOM 745 CA PHE A 53 67.932 −48.672 −6.762 1.00 24.68 A C ATOM 747 CB PHE A 53 66.919 −49.811 −6.571 1.00 25.20 A C ATOM 750 CG PHE A 53 66.487 −50.467 −7.862 1.00 28.10 A C ATOM 751 CD1 PHE A 53 65.998 −49.700 −8.920 1.00 30.01 A C ATOM 753 CE1 PHE A 53 65.592 −50.296 −10.112 1.00 30.91 A C ATOM 755 CZ PHE A 53 65.666 −51.679 −10.254 1.00 32.14 A C ATOM 757 CE2 PHE A 53 66.144 −52.458 −9.202 1.00 31.02 A C ATOM 759 CD2 PHE A 53 66.549 −51.851 −8.013 1.00 29.73 A C ATOM 761 C PHE A 53 67.879 −47.717 −5.566 1.00 23.76 A C ATOM 762 O PHE A 53 67.250 −46.663 −5.650 1.00 23.93 A O ATOM 764 N LEU A 54 68.535 −48.075 −4.465 1.00 22.52 A N ATOM 765 CA LEU A 54 68.557 −47.206 −3.286 1.00 21.36 A C ATOM 767 CB LEU A 54 69.083 −47.951 −2.055 1.00 21.51 A C ATOM 770 CG LEU A 54 68.781 −47.281 −0.708 1.00 21.41 A C ATOM 772 CD1 LEU A 54 67.301 −47.429 −0.372 1.00 20.97 A C ATOM 776 CD2 LEU A 54 69.653 −47.855 0.412 1.00 19.73 A C ATOM 780 C LEU A 54 69.401 −45.959 −3.541 1.00 20.27 A C ATOM 781 O LEU A 54 69.000 −44.856 −3.175 1.00 20.35 A O ATOM 783 N THR A 55 70.561 −46.142 −4.170 1.00 19.14 A N ATOM 784 CA THR A 55 71.463 −45.031 −4.495 1.00 18.11 A C ATOM 786 CB THR A 55 72.739 −45.521 −5.210 1.00 18.12 A C ATOM 788 OG1 THR A 55 73.383 −46.521 −4.412 1.00 17.71 A O ATOM 790 CG2 THR A 55 73.707 −44.363 −5.451 1.00 17.05 A C ATOM 794 C THR A 55 70.787 −43.994 −5.380 1.00 17.32 A C ATOM 795 O THR A 55 71.003 −42.798 −5.210 1.00 17.16 A O ATOM 797 N LEU A 56 69.975 −44.457 −6.327 1.00 16.99 A N ATOM 798 CA LEU A 56 69.204 −43.555 −7.179 1.00 17.23 A C ATOM 800 CB LEU A 56 68.488 −44.324 −8.295 1.00 17.55 A C ATOM 803 CG LEU A 56 67.539 −43.518 −9.196 1.00 18.41 A C ATOM 805 CD1 LEU A 56 68.246 −42.308 −9.796 1.00 18.81 A C ATOM 809 CD2 LEU A 56 66.954 −44.398 −10.296 1.00 19.59 A C ATOM 813 C LEU A 56 68.190 −42.785 −6.343 1.00 16.79 A C ATOM 814 O LEU A 56 68.100 −41.559 −6.443 1.00 16.92 A O ATOM 816 N LEU A 57 67.436 −43.511 −5.520 1.00 16.16 A N ATOM 817 CA LEU A 57 66.437 −42.899 −4.643 1.00 15.66 A C ATOM 819 CB LEU A 57 65.700 −43.972 −3.833 1.00 15.19 A C ATOM 822 CG LEU A 57 64.765 −44.889 −4.625 1.00 14.21 A C ATOM 824 CD1 LEU A 57 64.334 −46.067 −3.767 1.00 13.60 A C ATOM 828 CD2 LEU A 57 63.552 −44.133 −5.151 1.00 11.60 A C ATOM 832 C LEU A 57 67.055 −41.859 −3.701 1.00 15.52 A C ATOM 833 O LEU A 57 66.458 −40.809 −3.453 1.00 15.41 A O ATOM 835 N GLU A 58 68.254 −42.147 −3.197 1.00 15.21 A N ATOM 836 CA GLU A 58 68.940 −41.238 −2.274 1.00 14.75 A C ATOM 838 CB GLU A 58 69.981 −41.988 −1.430 1.00 14.86 A C ATOM 841 CG GLU A 58 69.363 −42.871 −0.341 1.00 15.06 A C ATOM 844 CD GLU A 58 70.385 −43.442 0.633 1.00 16.98 A C ATOM 845 OE1 GLU A 58 71.547 −42.981 0.644 1.00 19.17 A O ATOM 846 OE2 GLU A 58 70.020 −44.360 1.398 1.00 18.53 A O ATOM 847 C GLU A 58 69.575 −40.035 −2.975 1.00 14.11 A C ATOM 848 O GLU A 58 69.657 −38.959 −2.382 1.00 14.43 A O ATOM 850 N LEU A 59 70.020 −40.202 −4.221 1.00 13.22 A N ATOM 851 CA LEU A 59 70.528 −39.065 −4.999 1.00 12.44 A C ATOM 853 CB LEU A 59 71.180 −39.518 −6.311 1.00 12.19 A C ATOM 856 CG LEU A 59 71.677 −38.393 −7.235 1.00 10.80 A C ATOM 858 CD1 LEU A 59 72.780 −37.589 −6.572 1.00 9.85 A C ATOM 862 CD2 LEU A 59 72.154 −38.949 −8.566 1.00 9.48 A C ATOM 866 C LEU A 59 69.390 −38.100 −5.298 1.00 12.08 A C ATOM 867 O LEU A 59 69.549 −36.889 −5.164 1.00 11.53 A O ATOM 869 N ILE A 60 68.249 −38.649 −5.706 1.00 12.13 A N ATOM 870 CA ILE A 60 67.048 −37.856 −5.955 1.00 12.54 A C ATOM 872 CB ILE A 60 65.863 −38.745 −6.386 1.00 12.58 A C ATOM 874 CG1 ILE A 60 66.077 −39.276 −7.806 1.00 12.32 A C ATOM 877 CD1 ILE A 60 65.083 −40.350 −8.213 1.00 9.20 A C ATOM 881 CG2 ILE A 60 64.557 −37.964 −6.324 1.00 13.18 A C ATOM 885 C ILE A 60 66.649 −37.073 −4.707 1.00 13.10 A C ATOM 886 O ILE A 60 66.474 −35.853 −4.761 1.00 13.34 A O ATOM 888 N ASP A 61 66.512 −37.782 −3.587 1.00 13.39 A N ATOM 889 CA ASP A 61 66.154 −37.162 −2.310 1.00 13.31 A C ATOM 891 CB ASP A 61 66.150 −38.205 −1.185 1.00 13.34 A C ATOM 894 CG ASP A 61 65.640 −37.650 0.139 1.00 13.56 A C ATOM 895 OD1 ASP A 61 64.927 −36.625 0.136 1.00 12.03 A O ATOM 896 OD2 ASP A 61 65.946 −38.252 1.191 1.00 15.02 A O ATOM 897 C ASP A 61 67.121 −36.027 −1.979 1.00 13.29 A C ATOM 898 O ASP A 61 66.694 −34.889 −1.777 1.00 13.14 A O ATOM 900 N ASN A 62 68.416 −36.345 −1.943 1.00 13.31 A N ATOM 901 CA ASN A 62 69.463 −35.346 −1.704 1.00 13.68 A C ATOM 903 CB ASN A 62 70.865 −35.972 −1.816 1.00 13.84 A C ATOM 906 CG ASN A 62 71.306 −36.690 −0.542 1.00 13.75 A C ATOM 907 OD1 ASN A 62 70.678 −36.574 0.510 1.00 11.26 A O ATOM 908 ND2 ASN A 62 72.404 −37.432 −0.639 1.00 14.47 A N ATOM 911 C ASN A 62 69.363 −34.158 −2.661 1.00 14.11 A C ATOM 912 O ASN A 62 69.476 −33.005 −2.240 1.00 14.02 A O ATOM 914 N VAL A 63 69.150 −34.446 −3.944 1.00 14.45 A N ATOM 915 CA VAL A 63 68.998 −33.400 −4.957 1.00 14.74 A C ATOM 917 CB VAL A 63 68.845 −33.996 −6.377 1.00 14.56 A C ATOM 919 CG1 VAL A 63 68.343 −32.943 −7.354 1.00 14.88 A C ATOM 923 CG2 VAL A 63 70.165 −34.575 −6.854 1.00 14.45 A C ATOM 927 C VAL A 63 67.796 −32.503 −4.657 1.00 15.15 A C ATOM 928 O VAL A 63 67.890 −31.278 −4.762 1.00 15.47 A O ATOM 930 N GLN A 64 66.675 −33.114 −4.281 1.00 15.27 A N ATOM 931 CA GLN A 64 65.467 −32.355 −3.956 1.00 15.55 A C ATOM 933 CB GLN A 64 64.254 −33.283 −3.802 1.00 15.45 A C ATOM 936 CG GLN A 64 63.743 −33.865 −5.114 1.00 13.13 A C ATOM 939 CD GLN A 64 62.319 −34.385 −5.025 1.00 10.71 A C ATOM 940 OE1 GLN A 64 61.622 −34.470 −6.033 1.00 10.64 A O ATOM 941 NE2 GLN A 64 61.881 −34.731 −3.821 1.00 8.09 A N ATOM 944 C GLN A 64 65.650 −31.519 −2.688 1.00 15.86 A C ATOM 945 O GLN A 64 65.402 −30.311 −2.693 1.00 16.06 A O ATOM 947 N ARG A 65 66.089 −32.167 −1.612 1.00 15.84 A N ATOM 948 CA ARG A 65 66.241 −31.506 −0.313 1.00 15.98 A C ATOM 950 CB ARG A 65 66.627 −32.523 0.764 1.00 16.31 A C ATOM 953 CG ARG A 65 65.505 −33.496 1.113 1.00 18.72 A C ATOM 956 CD ARG A 65 65.879 −34.400 2.279 1.00 20.75 A C ATOM 959 NE ARG A 65 66.068 −33.641 3.514 1.00 22.71 A N ATOM 961 CZ ARG A 65 66.575 −34.133 4.642 1.00 24.75 A C ATOM 962 NH1 ARG A 65 66.956 −35.405 4.721 1.00 25.07 A N ATOM 965 NH2 ARG A 65 66.703 −33.343 5.704 1.00 26.41 A N ATOM 968 C ARG A 65 67.253 −30.361 −0.342 1.00 15.53 A C ATOM 969 O ARG A 65 67.039 −29.331 0.297 1.00 15.14 A O ATOM 971 N LEU A 66 68.338 −30.536 −1.099 1.00 15.13 A N ATOM 972 CA LEU A 66 69.343 −29.481 −1.287 1.00 14.45 A C ATOM 974 CB LEU A 66 70.588 −30.046 −1.979 1.00 14.24 A C ATOM 977 CG LEU A 66 71.505 −30.909 −1.108 1.00 13.57 A C ATOM 979 CD1 LEU A 66 72.413 −31.781 −1.961 1.00 13.45 A C ATOM 983 CD2 LEU A 66 72.329 −30.036 −0.178 1.00 12.36 A C ATOM 987 C LEU A 66 68.807 −28.271 −2.073 1.00 14.56 A C ATOM 988 O LEU A 66 69.544 −27.313 −2.332 1.00 14.45 A O ATOM 990 N GLY A 67 67.533 −28.330 −2.459 1.00 14.51 A N ATOM 991 CA GLY A 67 66.842 −27.203 −3.059 1.00 14.34 A C ATOM 994 C GLY A 67 66.968 −27.115 −4.564 1.00 14.63 A C ATOM 995 O GLY A 67 66.621 −26.093 −5.152 1.00 14.83 A O ATOM 997 N LEU A 68 67.448 −28.191 −5.189 1.00 15.09 A N ATOM 998 CA LEU A 68 67.656 −28.234 −6.638 1.00 15.36 A C ATOM 1000 CB LEU A 68 69.035 −28.828 −6.950 1.00 15.11 A C ATOM 1003 CG LEU A 68 70.243 −28.122 −6.332 1.00 14.67 A C ATOM 1005 CD1 LEU A 68 71.533 −28.793 −6.779 1.00 13.80 A C ATOM 1009 CD2 LEU A 68 70.256 −26.651 −6.699 1.00 12.27 A C ATOM 1013 C LEU A 68 66.577 −29.042 −7.371 1.00 15.95 A C ATOM 1014 O LEU A 68 66.679 −29.258 −8.578 1.00 16.42 A O ATOM 1016 N GLY A 69 65.543 −29.473 −6.653 1.00 16.33 A N ATOM 1017 CA GLY A 69 64.496 −30.320 −7.228 1.00 16.45 A C ATOM 1020 C GLY A 69 63.810 −29.734 −8.449 1.00 16.20 A C ATOM 1021 O GLY A 69 63.667 −30.410 −9.469 1.00 16.47 A O ATOM 1023 N TYR A 70 63.392 −28.474 −8.340 1.00 15.95 A N ATOM 1024 CA TYR A 70 62.726 −27.760 −9.440 1.00 15.71 A C ATOM 1026 CB TYR A 70 62.501 −26.284 −9.065 1.00 15.82 A C ATOM 1029 CG TYR A 70 63.755 −25.424 −9.114 1.00 14.12 A C ATOM 1030 CD1 TYR A 70 63.989 −24.561 −10.183 1.00 10.77 A C ATOM 1032 CE1 TYR A 70 65.133 −23.781 −10.237 1.00 10.89 A C ATOM 1034 CZ TYR A 70 66.066 −23.856 −9.216 1.00 11.24 A C ATOM 1035 OH TYR A 70 67.208 −23.084 −9.269 1.00 9.98 A O ATOM 1037 CE2 TYR A 70 65.859 −24.705 −8.145 1.00 11.41 A C ATOM 1039 CD2 TYR A 70 64.709 −25.485 −8.100 1.00 12.70 A C ATOM 1041 C TYR A 70 63.522 −27.841 −10.744 1.00 15.82 A C ATOM 1042 O TYR A 70 62.951 −27.909 −11.835 1.00 15.94 A O ATOM 1044 N ARG A 71 64.844 −27.839 −10.607 1.00 15.72 A N ATOM 1045 CA ARG A 71 65.757 −27.824 −11.737 1.00 15.71 A C ATOM 1047 CB ARG A 71 67.171 −27.540 −11.224 1.00 15.56 A C ATOM 1050 CG ARG A 71 68.175 −27.150 −12.286 1.00 16.84 A C ATOM 1053 CD ARG A 71 69.345 −26.386 −11.679 1.00 17.64 A C ATOM 1056 NE ARG A 71 69.076 −24.951 −11.600 1.00 18.02 A N ATOM 1058 CZ ARG A 71 69.124 −24.113 −12.633 1.00 18.91 A C ATOM 1059 NH1 ARG A 71 68.863 −22.828 −12.444 1.00 20.58 A N ATOM 1062 NH2 ARG A 71 69.428 −24.546 −13.856 1.00 18.44 A N ATOM 1065 C ARG A 71 65.729 −29.131 −12.535 1.00 15.68 A C ATOM 1066 O ARG A 71 65.790 −29.111 −13.764 1.00 15.69 A O ATOM 1068 N PHE A 72 65.625 −30.260 −11.838 1.00 15.70 A N ATOM 1069 CA PHE A 72 65.712 −31.573 −12.478 1.00 15.94 A C ATOM 1071 CB PHE A 72 66.838 −32.393 −11.835 1.00 15.86 A C ATOM 1074 CG PHE A 72 68.197 −31.764 −11.949 1.00 13.92 A C ATOM 1075 CD1 PHE A 72 68.891 −31.797 −13.151 1.00 13.93 A C ATOM 1077 CE1 PHE A 72 70.153 −31.229 −13.260 1.00 13.72 A C ATOM 1079 CZ PHE A 72 70.737 −30.625 −12.157 1.00 13.27 A C ATOM 1081 CE2 PHE A 72 70.057 −30.590 −10.951 1.00 12.76 A C ATOM 1083 CD2 PHE A 72 68.795 −31.161 −10.851 1.00 12.21 A C ATOM 1085 C PHE A 72 64.407 −32.371 −12.404 1.00 16.42 A C ATOM 1086 O PHE A 72 64.439 −33.601 −12.348 1.00 16.51 A O ATOM 1088 N GLU A 73 63.265 −31.686 −12.425 1.00 16.94 A N ATOM 1089 CA GLU A 73 61.967 −32.365 −12.315 1.00 17.43 A C ATOM 1091 CB GLU A 73 60.812 −31.361 −12.397 1.00 17.65 A C ATOM 1094 CG GLU A 73 59.425 −31.997 −12.254 1.00 19.25 A C ATOM 1097 CD GLU A 73 58.291 −30.983 −12.251 1.00 21.29 A C ATOM 1098 OE1 GLU A 73 58.563 −29.769 −12.127 1.00 22.11 A O ATOM 1099 OE2 GLU A 73 57.121 −31.410 −12.370 1.00 21.96 A O ATOM 1100 C GLU A 73 61.793 −33.454 −13.379 1.00 17.47 A C ATOM 1101 O GLU A 73 61.625 −34.628 −13.047 1.00 17.51 A O ATOM 1103 N SER A 74 61.841 −33.062 −14.649 1.00 17.73 A N ATOM 1104 CA SER A 74 61.656 −34.004 −15.756 1.00 18.06 A C ATOM 1106 CB SER A 74 61.792 −33.293 −17.103 1.00 18.17 A C ATOM 1109 OG SER A 74 63.117 −32.833 −17.303 1.00 19.43 A O ATOM 1111 C SER A 74 62.648 −35.161 −15.682 1.00 17.97 A C ATOM 1112 O SER A 74 62.264 −36.317 −15.846 1.00 17.90 A O ATOM 1114 N ASP A 75 63.915 −34.842 −15.425 1.00 18.18 A N ATOM 1115 CA ASP A 75 64.961 −35.862 −15.295 1.00 18.40 A C ATOM 1117 CB ASP A 75 66.344 −35.224 −15.112 1.00 18.40 A C ATOM 1120 CG ASP A 75 66.754 −34.365 −16.292 1.00 18.51 A C ATOM 1121 OD1 ASP A 75 67.526 −34.847 −17.144 1.00 15.74 A O ATOM 1122 OD2 ASP A 75 66.294 −33.207 −16.370 1.00 20.28 A O ATOM 1123 C ASP A 75 64.676 −36.804 −14.125 1.00 18.44 A C ATOM 1124 O ASP A 75 64.923 −38.008 −14.221 1.00 18.88 A O ATOM 1126 N ILE A 76 64.161 −36.247 −13.030 1.00 18.14 A N ATOM 1127 CA ILE A 76 63.789 −37.033 −11.854 1.00 17.84 A C ATOM 1129 CB ILE A 76 63.466 −36.129 −10.640 1.00 17.71 A C ATOM 1131 CG1 ILE A 76 64.758 −35.575 −10.035 1.00 16.61 A C ATOM 1134 CD1 ILE A 76 64.561 −34.317 −9.224 1.00 14.92 A C ATOM 1138 CG2 ILE A 76 62.694 −36.904 −9.580 1.00 17.99 A C ATOM 1142 C ILE A 76 62.594 −37.930 −12.160 1.00 17.97 A C ATOM 1143 O ILE A 76 62.658 −39.136 −11.939 1.00 18.10 A O ATOM 1145 N ARG A 77 61.515 −37.341 −12.674 1.00 18.15 A N ATOM 1146 CA ARG A 77 60.331 −38.107 −13.077 1.00 18.64 A C ATOM 1148 CB ARG A 77 59.350 −37.225 −13.851 1.00 18.82 A C ATOM 1151 CG ARG A 77 58.565 −36.253 −12.988 1.00 20.98 A C ATOM 1154 CD ARG A 77 57.624 −35.398 −13.835 1.00 23.38 A C ATOM 1157 NE ARG A 77 56.595 −36.205 −14.492 1.00 24.73 A N ATOM 1159 CZ ARG A 77 55.471 −36.635 −13.915 1.00 25.64 A C ATOM 1160 NH1 ARG A 77 55.192 −36.346 −12.645 1.00 26.60 A N ATOM 1163 NH2 ARG A 77 54.613 −37.364 −14.618 1.00 25.52 A N ATOM 1166 C ARG A 77 60.711 −39.312 −13.938 1.00 18.58 A C ATOM 1167 O ARG A 77 60.240 −40.427 −13.706 1.00 18.61 A O ATOM 1169 N GLY A 78 61.568 −39.075 −14.928 1.00 18.28 A N ATOM 1170 CA GLY A 78 62.057 −40.134 −15.802 1.00 18.20 A C ATOM 1173 C GLY A 78 62.696 −41.279 −15.040 1.00 18.14 A C ATOM 1174 O GLY A 78 62.502 −42.445 −15.386 1.00 18.30 A O ATOM 1176 N ALA A 79 63.458 −40.944 −14.001 1.00 18.02 A N ATOM 1177 CA ALA A 79 64.134 −41.945 −13.180 1.00 18.14 A C ATOM 1179 CB ALA A 79 65.142 −41.280 −12.258 1.00 18.16 A C ATOM 1183 C ALA A 79 63.134 −42.763 −12.369 1.00 18.13 A C ATOM 1184 O ALA A 79 63.227 −43.991 −12.308 1.00 18.34 A O ATOM 1186 N LEU A 80 62.179 −42.073 −11.754 1.00 18.13 A N ATOM 1187 CA LEU A 80 61.136 −42.727 −10.969 1.00 18.20 A C ATOM 1189 CB LEU A 80 60.348 −41.693 −10.161 1.00 17.90 A C ATOM 1192 CG LEU A 80 61.135 −41.067 −9.009 1.00 16.44 A C ATOM 1194 CD1 LEU A 80 60.478 −39.790 −8.526 1.00 15.42 A C ATOM 1198 CD2 LEU A 80 61.285 −42.059 −7.871 1.00 15.55 A C ATOM 1202 C LEU A 80 60.189 −43.536 −11.851 1.00 18.82 A C ATOM 1203 O LEU A 80 59.655 −44.556 −11.418 1.00 18.88 A O ATOM 1205 N ASP A 81 59.982 −43.083 −13.084 1.00 19.44 A N ATOM 1206 CA ASP A 81 59.149 −43.819 −14.033 1.00 20.08 A C ATOM 1208 CB ASP A 81 58.894 −42.984 −15.290 1.00 20.26 A C ATOM 1211 CG ASP A 81 57.690 −43.464 −16.067 1.00 21.37 A C ATOM 1212 OD1 ASP A 81 57.879 −44.129 −17.108 1.00 23.00 A O ATOM 1213 OD2 ASP A 81 56.554 −43.186 −15.624 1.00 22.87 A O ATOM 1214 C ASP A 81 59.810 −45.149 −14.406 1.00 20.30 A C ATOM 1215 O ASP A 81 59.133 −46.174 −14.523 1.00 19.67 A O ATOM 1217 N ARG A 82 61.131 −45.116 −14.583 1.00 20.83 A N ATOM 1218 CA ARG A 82 61.920 −46.322 −14.853 1.00 21.36 A C ATOM 1220 CB ARG A 82 63.315 −45.951 −15.375 1.00 21.67 A C ATOM 1223 CG ARG A 82 63.351 −45.688 −16.878 1.00 23.80 A C ATOM 1226 CD ARG A 82 64.738 −45.280 −17.376 1.00 25.75 A C ATOM 1229 NE ARG A 82 64.961 −43.834 −17.262 1.00 27.68 A N ATOM 1231 CZ ARG A 82 65.707 −43.227 −16.335 1.00 28.28 A C ATOM 1232 NH1 ARG A 82 66.349 −43.915 −15.389 1.00 27.87 A N ATOM 1235 NH2 ARG A 82 65.813 −41.902 −16.356 1.00 27.78 A N ATOM 1238 C ARG A 82 62.038 −47.229 −13.623 1.00 21.47 A C ATOM 1239 O ARG A 82 62.181 −48.446 −13.760 1.00 21.30 A O ATOM 1241 N PHE A 83 61.981 −46.633 −12.432 1.00 21.68 A N ATOM 1242 CA PHE A 83 61.970 −47.385 −11.171 1.00 21.75 A C ATOM 1244 CB PHE A 83 62.026 −46.418 −9.981 1.00 21.95 A C ATOM 1247 CG PHE A 83 62.097 −47.097 −8.637 1.00 21.67 A C ATOM 1248 CD1 PHE A 83 63.190 −47.877 −8.301 1.00 22.11 A C ATOM 1250 CE1 PHE A 83 63.268 −48.500 −7.064 1.00 21.50 A C ATOM 1252 CZ PHE A 83 62.250 −48.336 −6.144 1.00 21.28 A C ATOM 1254 CE2 PHE A 83 61.155 −47.554 −6.464 1.00 21.20 A C ATOM 1256 CD2 PHE A 83 61.082 −46.936 −7.704 1.00 21.17 A C ATOM 1258 C PHE A 83 60.733 −48.277 −11.059 1.00 21.71 A C ATOM 1259 O PHE A 83 60.838 −49.450 −10.696 1.00 21.49 A O ATOM 1261 N VAL A 84 59.567 −47.708 −11.365 1.00 21.86 A N ATOM 1262 CA VAL A 84 58.309 −48.454 −11.376 1.00 21.92 A C ATOM 1264 CB VAL A 84 57.087 −47.509 −11.496 1.00 21.73 A C ATOM 1266 CG1 VAL A 84 55.821 −48.285 −11.843 1.00 21.28 A C ATOM 1270 CG2 VAL A 84 56.898 −46.731 −10.209 1.00 20.78 A C ATOM 1274 C VAL A 84 58.297 −49.451 −12.531 1.00 22.75 A C ATOM 1275 O VAL A 84 58.070 −50.646 −12.323 1.00 22.96 A O ATOM 1277 N SER A 85 58.560 −48.953 −13.740 1.00 23.25 A N ATOM 1278 CA SER A 85 58.542 −49.777 −14.959 1.00 23.36 A C ATOM 1280 CB SER A 85 59.043 −48.969 −16.160 1.00 23.36 A C ATOM 1283 OG SER A 85 58.267 −47.796 −16.343 1.00 23.72 A O ATOM 1285 C SER A 85 59.363 −51.059 −14.828 1.00 23.09 A C ATOM 1286 O SER A 85 58.944 −52.115 −15.300 1.00 22.81 A O ATOM 1288 N SER A 86 60.521 −50.958 −14.176 1.00 23.31 A N ATOM 1289 CA SER A 86 61.421 −52.099 −13.992 1.00 23.83 A C ATOM 1291 CB SER A 86 62.880 −51.626 −14.021 1.00 23.95 A C ATOM 1294 OG SER A 86 63.188 −50.822 −12.894 1.00 24.38 A O ATOM 1296 C SER A 86 61.157 −52.885 −12.698 1.00 24.08 A C ATOM 1297 O SER A 86 61.966 −53.729 −12.312 1.00 24.00 A O ATOM 1299 N GLY A 87 60.037 −52.604 −12.032 1.00 24.44 A N ATOM 1300 CA GLY A 87 59.645 −53.333 −10.824 1.00 24.69 A C ATOM 1303 C GLY A 87 60.534 −53.124 −9.607 1.00 24.77 A C ATOM 1304 O GLY A 87 60.542 −53.951 −8.693 1.00 24.93 A O ATOM 1306 N GLY A 88 61.283 −52.024 −9.585 1.00 24.83 A N ATOM 1307 CA GLY A 88 62.142 −51.701 −8.449 1.00 24.84 A C ATOM 1310 C GLY A 88 61.331 −51.396 −7.203 1.00 24.89 A C ATOM 1311 O GLY A 88 61.688 −51.824 −6.104 1.00 24.71 A O ATOM 1313 N PHE A 89 60.235 −50.657 −7.386 1.00 24.99 A N ATOM 1314 CA PHE A 89 59.296 −50.336 −6.304 1.00 24.94 A C ATOM 1316 CB PHE A 89 58.218 −49.363 −6.802 1.00 25.23 A C ATOM 1319 CG PHE A 89 57.181 −49.012 −5.769 1.00 25.50 A C ATOM 1320 CD1 PHE A 89 57.546 −48.380 −4.588 1.00 25.76 A C ATOM 1322 CE1 PHE A 89 56.592 −48.050 −3.630 1.00 26.18 A C ATOM 1324 CZ PHE A 89 55.253 −48.346 −3.855 1.00 27.09 A C ATOM 1326 CE2 PHE A 89 54.874 −48.971 −5.033 1.00 27.63 A C ATOM 1328 CD2 PHE A 89 55.838 −49.300 −5.984 1.00 27.27 A C ATOM 1330 C PHE A 89 58.647 −51.599 −5.746 1.00 24.65 A C ATOM 1331 O PHE A 89 58.438 −51.709 −4.538 1.00 24.51 A O ATOM 1333 N ASP A 90 58.330 −52.545 −6.629 1.00 24.41 A N ATOM 1334 CA ASP A 90 57.825 −53.851 −6.207 1.00 24.29 A C ATOM 1336 CB ASP A 90 57.210 −54.613 −7.392 1.00 24.60 A C ATOM 1339 CG ASP A 90 56.123 −55.595 −6.962 1.00 25.71 A C ATOM 1340 OD1 ASP A 90 55.046 −55.135 −6.518 1.00 24.61 A O ATOM 1341 OD2 ASP A 90 56.341 −56.822 −7.078 1.00 27.27 A O ATOM 1342 C ASP A 90 58.946 −54.677 −5.563 1.00 23.50 A C ATOM 1343 O ASP A 90 58.687 −55.508 −4.694 1.00 23.34 A O ATOM 1345 N ALA A 91 60.185 −54.439 −5.992 1.00 22.93 A N ATOM 1346 CA ALA A 91 61.356 −55.122 −5.434 1.00 22.68 A C ATOM 1348 CB ALA A 91 62.574 −54.900 −6.326 1.00 22.43 A C ATOM 1352 C ALA A 91 61.666 −54.683 −3.999 1.00 22.49 A C ATOM 1353 O ALA A 91 61.957 −55.520 −3.142 1.00 22.56 A O ATOM 1355 N VAL A 92 61.600 −53.377 −3.741 1.00 22.18 A N ATOM 1356 CA VAL A 92 61.948 −52.834 −2.421 1.00 21.87 A C ATOM 1358 CB VAL A 92 62.228 −51.304 −2.465 1.00 22.06 A C ATOM 1360 CG1 VAL A 92 63.296 −50.983 −3.507 1.00 21.68 A C ATOM 1364 CG2 VAL A 92 60.952 −50.515 −2.735 1.00 22.62 A C ATOM 1368 C VAL A 92 60.890 −53.133 −1.351 1.00 21.46 A C ATOM 1369 O VAL A 92 61.237 −53.335 −0.189 1.00 21.07 A O ATOM 1371 N THR A 93 59.614 −53.173 −1.738 1.00 21.50 A N ATOM 1372 CA THR A 93 58.538 −53.555 −0.809 1.00 21.48 A C ATOM 1374 CB THR A 93 57.133 −53.525 −1.464 1.00 21.32 A C ATOM 1376 OG1 THR A 93 57.103 −54.398 −2.600 1.00 20.80 A O ATOM 1378 CG2 THR A 93 56.757 −52.110 −1.886 1.00 20.81 A C ATOM 1382 C THR A 93 58.770 −54.947 −0.226 1.00 21.77 A C ATOM 1383 O THR A 93 58.340 −55.229 0.894 1.00 22.39 A O ATOM 1385 N LYS A 94 59.447 −55.807 −0.987 1.00 21.47 A N ATOM 1386 CA LYS A 94 59.797 −57.146 −0.523 1.00 21.19 A C ATOM 1388 CB LYS A 94 60.015 −58.087 −1.715 1.00 21.47 A C ATOM 1391 CG LYS A 94 58.821 −58.222 −2.660 1.00 22.94 A C ATOM 1394 CD LYS A 94 57.596 −58.829 −1.978 1.00 24.09 A C ATOM 1397 CE LYS A 94 56.432 −58.970 −2.950 1.00 24.08 A C ATOM 1400 NZ LYS A 94 55.133 −59.149 −2.242 1.00 24.08 A N ATOM 1404 C LYS A 94 61.042 −57.168 0.368 1.00 20.63 A C ATOM 1405 O LYS A 94 61.150 −58.036 1.233 1.00 20.30 A O ATOM 1407 N THR A 95 61.969 −56.225 0.167 1.00 20.41 A N ATOM 1408 CA THR A 95 63.302 −56.301 0.795 1.00 20.29 A C ATOM 1410 CB THR A 95 64.398 −56.575 −0.269 1.00 20.32 A C ATOM 1412 OG1 THR A 95 64.375 −55.546 −1.265 1.00 20.66 A O ATOM 1414 CG2 THR A 95 64.186 −57.931 −0.931 1.00 20.65 A C ATOM 1418 C THR A 95 63.784 −55.102 1.631 1.00 19.83 A C ATOM 1419 O THR A 95 64.777 −55.238 2.345 1.00 19.98 A O ATOM 1421 N SER A 96 63.120 −53.946 1.555 1.00 19.31 A N ATOM 1422 CA SER A 96 63.620 −52.739 2.247 1.00 18.82 A C ATOM 1424 CB SER A 96 64.689 −52.051 1.391 1.00 18.43 A C ATOM 1427 OG SER A 96 65.227 −50.917 2.053 1.00 17.09 A O ATOM 1429 C SER A 96 62.536 −51.716 2.614 1.00 18.93 A C ATOM 1430 O SER A 96 61.889 −51.146 1.734 1.00 19.15 A O ATOM 1432 N LEU A 97 62.364 −51.474 3.916 1.00 18.65 A N ATOM 1433 CA LEU A 97 61.415 −50.467 4.405 1.00 18.06 A C ATOM 1435 CB LEU A 97 61.285 −50.521 5.935 1.00 17.85 A C ATOM 1438 CG LEU A 97 60.459 −49.416 6.612 1.00 16.18 A C ATOM 1440 CD1 LEU A 97 59.070 −49.303 6.001 1.00 15.61 A C ATOM 1444 CD2 LEU A 97 60.358 −49.662 8.105 1.00 13.42 A C ATOM 1448 C LEU A 97 61.852 −49.076 3.982 1.00 18.03 A C ATOM 1449 O LEU A 97 61.048 −48.303 3.461 1.00 18.07 A O ATOM 1451 N HIS A 98 63.126 −48.767 4.217 1.00 18.04 A N ATOM 1452 CA HIS A 98 63.707 −47.478 3.831 1.00 18.00 A C ATOM 1454 CB HIS A 98 65.214 −47.475 4.101 1.00 18.04 A C ATOM 1457 CG HIS A 98 65.911 −46.239 3.626 1.00 18.24 A C ATOM 1458 ND1 HIS A 98 65.437 −44.972 3.886 1.00 18.83 A N ATOM 1460 CE1 HIS A 98 66.252 −44.080 3.351 1.00 20.11 A C ATOM 1462 NE2 HIS A 98 67.241 −44.724 2.757 1.00 20.52 A N ATOM 1464 CD2 HIS A 98 67.051 −46.075 2.915 1.00 19.92 A C ATOM 1466 C HIS A 98 63.437 −47.172 2.360 1.00 17.56 A C ATOM 1467 O HIS A 98 62.942 −46.095 2.019 1.00 17.27 A O ATOM 1469 N GLY A 99 63.761 −48.135 1.502 1.00 17.20 A N ATOM 1470 CA GLY A 99 63.515 −48.016 0.071 1.00 16.81 A C ATOM 1473 C GLY A 99 62.044 −47.848 −0.254 1.00 16.25 A C ATOM 1474 O GLY A 99 61.689 −47.056 −1.122 1.00 16.14 A O ATOM 1476 N THR A 100 61.192 −48.592 0.449 1.00 15.87 A N ATOM 1477 CA THR A 100 59.742 −48.502 0.257 1.00 15.58 A C ATOM 1479 CB THR A 100 59.001 −49.660 0.962 1.00 15.34 A C ATOM 1481 OG1 THR A 100 59.592 −50.906 0.583 1.00 14.29 A O ATOM 1483 CG2 THR A 100 57.525 −49.672 0.583 1.00 14.51 A C ATOM 1487 C THR A 100 59.184 −47.172 0.767 1.00 15.52 A C ATOM 1488 O THR A 100 58.246 −46.634 0.186 1.00 15.09 A O ATOM 1490 N ALA A 101 59.768 −46.652 1.846 1.00 15.65 A N ATOM 1491 CA ALA A 101 59.332 −45.388 2.444 1.00 15.65 A C ATOM 1493 CB ALA A 101 59.822 −45.290 3.884 1.00 15.54 A C ATOM 1497 C ALA A 101 59.814 −44.183 1.638 1.00 15.54 A C ATOM 1498 O ALA A 101 59.057 −43.237 1.409 1.00 15.42 A O ATOM 1500 N LEU A 102 61.076 −44.218 1.219 1.00 15.41 A N ATOM 1501 CA LEU A 102 61.648 −43.146 0.408 1.00 15.42 A C ATOM 1503 CB LEU A 102 63.157 −43.355 0.241 1.00 15.36 A C ATOM 1506 CG LEU A 102 63.945 −42.270 −0.501 1.00 14.98 A C ATOM 1508 CD1 LEU A 102 63.702 −40.900 0.116 1.00 15.72 A C ATOM 1512 CD2 LEU A 102 65.430 −42.604 −0.499 1.00 13.41 A C ATOM 1516 C LEU A 102 60.971 −43.076 −0.961 1.00 15.48 A C ATOM 1517 O LEU A 102 60.618 −41.993 −1.434 1.00 15.70 A O ATOM 1519 N SER A 103 60.789 −44.237 −1.585 1.00 15.25 A N ATOM 1520 CA SER A 103 60.193 −44.320 −2.919 1.00 15.14 A C ATOM 1522 CB SER A 103 60.410 −45.711 −3.516 1.00 15.40 A C ATOM 1525 OG SER A 103 59.767 −46.707 −2.738 1.00 16.19 A O ATOM 1527 C SER A 103 58.702 −44.001 −2.923 1.00 14.61 A C ATOM 1528 O SER A 103 58.181 −43.506 −3.919 1.00 14.62 A O ATOM 1530 N PHE A 104 58.019 −44.307 −1.822 1.00 14.22 A N ATOM 1531 CA PHE A 104 56.601 −43.979 −1.673 1.00 13.75 A C ATOM 1533 CB PHE A 104 56.071 −44.474 −0.323 1.00 13.69 A C ATOM 1536 CG PHE A 104 54.603 −44.227 −0.113 1.00 13.93 A C ATOM 1537 CD1 PHE A 104 53.687 −45.255 −0.272 1.00 14.16 A C ATOM 1539 CE1 PHE A 104 52.332 −45.031 −0.075 1.00 15.68 A C ATOM 1541 CZ PHE A 104 51.878 −43.770 0.287 1.00 15.52 A C ATOM 1543 CE2 PHE A 104 52.780 −42.737 0.450 1.00 15.16 A C ATOM 1545 CD2 PHE A 104 54.137 −42.968 0.254 1.00 15.63 A C ATOM 1547 C PHE A 104 56.419 −42.475 −1.764 1.00 13.26 A C ATOM 1548 O PHE A 104 55.580 −41.984 −2.517 1.00 13.35 A O ATOM 1550 N ARG A 105 57.219 −41.756 −0.983 1.00 12.79 A N ATOM 1551 CA ARG A 105 57.129 −40.305 −0.889 1.00 12.24 A C ATOM 1553 CB ARG A 105 58.131 −39.786 0.151 1.00 12.47 A C ATOM 1556 CG ARG A 105 58.043 −38.289 0.429 1.00 12.65 A C ATOM 1559 CD ARG A 105 58.675 −37.930 1.765 1.00 12.12 A C ATOM 1562 NE ARG A 105 60.085 −38.315 1.836 1.00 12.56 A N ATOM 1564 CZ ARG A 105 61.099 −37.626 1.307 1.00 12.59 A C ATOM 1565 NH1 ARG A 105 60.889 −36.492 0.641 1.00 10.93 A N ATOM 1568 NH2 ARG A 105 62.342 −38.081 1.442 1.00 13.27 A N ATOM 1571 C ARG A 105 57.377 −39.646 −2.240 1.00 11.50 A C ATOM 1572 O ARG A 105 56.522 −38.911 −2.739 1.00 11.41 A O ATOM 1574 N LEU A 106 58.538 −39.929 −2.828 1.00 10.65 A N ATOM 1575 CA LEU A 106 58.960 −39.289 −4.077 1.00 10.07 A C ATOM 1577 CB LEU A 106 60.342 −39.797 −4.503 1.00 9.65 A C ATOM 1580 CG LEU A 106 61.518 −39.446 −3.591 1.00 8.79 A C ATOM 1582 CD1 LEU A 106 62.798 −40.057 −4.123 1.00 7.06 A C ATOM 1586 CD2 LEU A 106 61.665 −37.943 −3.455 1.00 8.58 A C ATOM 1590 C LEU A 106 57.960 −39.510 −5.210 1.00 10.35 A C ATOM 1591 O LEU A 106 57.659 −38.591 −5.966 1.00 9.93 A O ATOM 1593 N LEU A 107 57.448 −40.731 −5.322 1.00 11.25 A N ATOM 1594 CA LEU A 107 56.482 −41.059 −6.364 1.00 11.96 A C ATOM 1596 CB LEU A 107 56.168 −42.561 −6.362 1.00 11.90 A C ATOM 1599 CG LEU A 107 57.282 −43.462 −6.910 1.00 10.93 A C ATOM 1601 CD1 LEU A 107 57.110 −44.907 −6.454 1.00 9.95 A C ATOM 1605 CD2 LEU A 107 57.338 −43.384 −8.426 1.00 9.78 A C ATOM 1609 C LEU A 107 55.211 −40.227 −6.190 1.00 12.95 A C ATOM 1610 O LEU A 107 54.855 −39.443 −7.073 1.00 13.19 A O ATOM 1612 N ARG A 108 54.552 −40.368 −5.041 1.00 13.67 A N ATOM 1613 CA ARG A 108 53.324 −39.618 −4.765 1.00 14.20 A C ATOM 1615 CB ARG A 108 52.790 −39.925 −3.364 1.00 14.17 A C ATOM 1618 CG ARG A 108 51.491 −39.199 −3.039 1.00 14.69 A C ATOM 1621 CD ARG A 108 50.825 −39.745 −1.794 1.00 15.20 A C ATOM 1624 NE ARG A 108 50.129 −41.006 −2.043 1.00 15.73 A N ATOM 1626 CZ ARG A 108 49.489 −41.709 −1.110 1.00 16.84 A C ATOM 1627 NH1 ARG A 108 49.452 −41.284 0.152 1.00 18.23 A N ATOM 1630 NH2 ARG A 108 48.886 −42.847 −1.436 1.00 16.02 A N ATOM 1633 C ARG A 108 53.527 −38.112 −4.927 1.00 14.71 A C ATOM 1634 O ARG A 108 52.645 −37.421 −5.434 1.00 15.28 A O ATOM 1636 N GLN A 109 54.683 −37.613 −4.491 1.00 15.38 A N ATOM 1637 CA GLN A 109 55.061 −36.209 −4.704 1.00 15.97 A C ATOM 1639 CB GLN A 109 56.475 −35.945 −4.163 1.00 15.84 A C ATOM 1642 CG GLN A 109 57.029 −34.541 −4.425 1.00 14.14 A C ATOM 1645 CD GLN A 109 58.523 −34.431 −4.153 1.00 12.90 A C ATOM 1646 OE1 GLN A 109 59.146 −35.355 −3.631 1.00 11.02 A O ATOM 1647 NE2 GLN A 109 59.102 −33.291 −4.508 1.00 12.83 A N ATOM 1650 C GLN A 109 55.000 −35.856 −6.190 1.00 16.80 A C ATOM 1651 O GLN A 109 54.554 −34.764 −6.555 1.00 17.24 A O ATOM 1653 N HIS A 110 55.441 −36.790 −7.034 1.00 17.12 A N ATOM 1654 CA HIS A 110 55.471 −36.593 −8.484 1.00 17.38 A C ATOM 1656 CB HIS A 110 56.786 −37.139 −9.056 1.00 17.33 A C ATOM 1659 CG HIS A 110 57.991 −36.346 −8.656 1.00 16.17 A C ATOM 1660 ND1 HIS A 110 58.171 −35.032 −9.032 1.00 16.90 A N ATOM 1662 CE1 HIS A 110 59.317 −34.590 −8.545 1.00 16.88 A C ATOM 1664 NE2 HIS A 110 59.888 −35.571 −7.870 1.00 15.81 A N ATOM 1666 CD2 HIS A 110 59.080 −36.681 −7.926 1.00 14.86 A C ATOM 1668 C HIS A 110 54.264 −37.210 −9.211 1.00 17.87 A C ATOM 1669 O HIS A 110 54.390 −37.690 −10.344 1.00 17.97 A O ATOM 1671 N GLY A 111 53.101 −37.208 −8.557 1.00 18.23 A N ATOM 1672 CA GLY A 111 51.832 −37.543 −9.215 1.00 18.60 A C ATOM 1675 C GLY A 111 51.538 −39.016 −9.464 1.00 19.18 A C ATOM 1676 O GLY A 111 50.428 −39.362 −9.877 1.00 19.51 A O ATOM 1678 N PHE A 112 52.515 −39.888 −9.221 1.00 19.34 A N ATOM 1679 CA PHE A 112 52.326 −41.326 −9.398 1.00 19.07 A C ATOM 1681 CB PHE A 112 53.663 −42.064 −9.292 1.00 19.21 A C ATOM 1684 CG PHE A 112 54.544 −41.904 −10.495 1.00 20.15 A C ATOM 1685 CD1 PHE A 112 54.129 −42.360 −11.740 1.00 21.80 A C ATOM 1687 CE1 PHE A 112 54.945 −42.227 −12.855 1.00 22.75 A C ATOM 1689 CZ PHE A 112 56.195 −41.642 −12.730 1.00 23.18 A C ATOM 1691 CE2 PHE A 112 56.624 −41.192 −11.489 1.00 22.64 A C ATOM 1693 CD2 PHE A 112 55.800 −41.326 −10.380 1.00 21.27 A C ATOM 1695 C PHE A 112 51.369 −41.887 −8.357 1.00 18.69 A C ATOM 1696 O PHE A 112 51.144 −41.275 −7.313 1.00 18.60 A O ATOM 1698 N GLU A 113 50.817 −43.060 −8.645 1.00 18.61 A N ATOM 1699 CA GLU A 113 49.921 −43.735 −7.715 1.00 18.65 A C ATOM 1701 CB GLU A 113 48.699 −44.292 −8.447 1.00 18.82 A C ATOM 1704 CG GLU A 113 47.633 −43.241 −8.709 1.00 21.49 A C ATOM 1707 CD GLU A 113 46.566 −43.700 −9.687 1.00 25.30 A C ATOM 1708 OE1 GLU A 113 45.849 −42.829 −10.227 1.00 27.79 A O ATOM 1709 OE2 GLU A 113 46.440 −44.923 −9.917 1.00 27.48 A O ATOM 1710 C GLU A 113 50.648 −44.841 −6.959 1.00 18.07 A C ATOM 1711 O GLU A 113 50.854 −45.939 −7.483 1.00 18.36 A O ATOM 1713 N VAL A 114 51.060 −44.521 −5.735 1.00 17.12 A N ATOM 1714 CA VAL A 114 51.481 −45.524 −4.765 1.00 16.39 A C ATOM 1716 CB VAL A 114 52.750 −45.101 −4.008 1.00 15.83 A C ATOM 1718 CG1 VAL A 114 53.919 −45.005 −4.964 1.00 15.16 A C ATOM 1722 CG2 VAL A 114 52.533 −43.784 −3.276 1.00 15.50 A C ATOM 1726 C VAL A 114 50.335 −45.721 −3.781 1.00 16.53 A C ATOM 1727 O VAL A 114 49.538 −44.810 −3.572 1.00 16.32 A O ATOM 1729 N SER A 115 50.247 −46.912 −3.194 1.00 17.04 A N ATOM 1730 CA SER A 115 49.195 −47.223 −2.228 1.00 17.55 A C ATOM 1732 CB SER A 115 48.308 −48.355 −2.743 1.00 17.82 A C ATOM 1735 OG SER A 115 47.197 −48.552 −1.884 1.00 18.67 A O ATOM 1737 C SER A 115 49.781 −47.609 −0.876 1.00 17.69 A C ATOM 1738 O SER A 115 50.899 −48.124 −0.795 1.00 17.50 A O ATOM 1740 N GLN A 116 49.006 −47.374 0.181 1.00 17.82 A N ATOM 1741 CA GLN A 116 49.454 −47.623 1.555 1.00 17.95 A C ATOM 1743 CB GLN A 116 48.420 −47.101 2.559 1.00 17.90 A C ATOM 1746 CG GLN A 116 47.068 −47.810 2.515 1.00 18.34 A C ATOM 1749 CD GLN A 116 46.133 −47.374 3.628 1.00 18.56 A C ATOM 1750 OE1 GLN A 116 46.556 −46.788 4.625 1.00 17.49 A O ATOM 1751 NE2 GLN A 116 44.849 −47.667 3.464 1.00 20.40 A N ATOM 1754 C GLN A 116 49.769 −49.092 1.862 1.00 18.13 A C ATOM 1755 O GLN A 116 50.414 −49.388 2.869 1.00 18.57 A O ATOM 1757 N GLU A 117 49.310 −50.003 1.004 1.00 17.94 A N ATOM 1758 CA GLU A 117 49.597 −51.434 1.157 1.00 17.83 A C ATOM 1760 CB GLU A 117 48.454 −52.279 0.566 1.00 17.98 A C ATOM 1763 CG GLU A 117 48.249 −52.140 −0.952 1.00 19.01 A C ATOM 1766 CD GLU A 117 46.780 −52.207 −1.378 1.00 20.24 A C ATOM 1767 OE1 GLU A 117 45.909 −51.625 −0.689 1.00 19.48 A O ATOM 1768 OE2 GLU A 117 46.500 −52.832 −2.424 1.00 20.64 A O ATOM 1769 C GLU A 117 50.956 −51.847 0.566 1.00 17.49 A C ATOM 1770 O GLU A 117 51.215 −53.034 0.373 1.00 17.44 A O ATOM 1772 N ALA A 118 51.817 −50.870 0.282 1.00 17.38 A N ATOM 1773 CA ALA A 118 53.218 −51.141 −0.044 1.00 17.57 A C ATOM 1775 CB ALA A 118 53.836 −49.962 −0.770 1.00 17.88 A C ATOM 1779 C ALA A 118 54.002 −51.431 1.228 1.00 17.50 A C ATOM 1780 O ALA A 118 55.040 −52.090 1.184 1.00 17.67 A O ATOM 1782 N PHE A 119 53.498 −50.929 2.354 1.00 17.52 A N ATOM 1783 CA PHE A 119 54.126 −51.132 3.655 1.00 17.68 A C ATOM 1785 CB PHE A 119 53.830 −49.945 4.578 1.00 17.42 A C ATOM 1788 CG PHE A 119 54.301 −48.622 4.038 1.00 15.73 A C ATOM 1789 CD1 PHE A 119 53.399 −47.701 3.526 1.00 14.47 A C ATOM 1791 CE1 PHE A 119 53.833 −46.484 3.029 1.00 15.03 A C ATOM 1793 CZ PHE A 119 55.181 −46.175 3.039 1.00 15.34 A C ATOM 1795 CE2 PHE A 119 56.091 −47.088 3.544 1.00 14.74 A C ATOM 1797 CD2 PHE A 119 55.649 −48.301 4.040 1.00 14.46 A C ATOM 1799 C PHE A 119 53.666 −52.422 4.336 1.00 18.67 A C ATOM 1800 O PHE A 119 54.193 −52.782 5.390 1.00 18.41 A O ATOM 1802 N SER A 120 52.693 −53.112 3.735 1.00 20.10 A N ATOM 1803 CA SER A 120 52.070 −54.302 4.342 1.00 20.78 A C ATOM 1805 CB SER A 120 50.966 −54.859 3.433 1.00 20.80 A C ATOM 1808 OG SER A 120 51.505 −55.402 2.240 1.00 21.10 A O ATOM 1810 C SER A 120 53.062 −55.417 4.679 1.00 21.20 A C ATOM 1811 O SER A 120 52.863 −56.152 5.645 1.00 21.27 A O ATOM 1813 N GLY A 121 54.121 −55.542 3.884 1.00 22.05 A N ATOM 1814 CA GLY A 121 55.175 −56.517 4.156 1.00 22.98 A C ATOM 1817 C GLY A 121 55.878 −56.295 5.487 1.00 23.82 A C ATOM 1818 O GLY A 121 56.330 −57.252 6.121 1.00 23.57 A O ATOM 1820 N PHE A 122 55.946 −55.034 5.918 1.00 24.93 A N ATOM 1821 CA PHE A 122 56.665 −54.646 7.137 1.00 25.54 A C ATOM 1823 CB PHE A 122 57.384 −53.304 6.922 1.00 25.57 A C ATOM 1826 CG PHE A 122 58.118 −53.209 5.610 1.00 25.40 A C ATOM 1827 CD1 PHE A 122 59.366 −53.796 5.448 1.00 26.67 A C ATOM 1829 CE1 PHE A 122 60.042 −53.710 4.235 1.00 26.81 A C ATOM 1831 CZ PHE A 122 59.467 −53.034 3.170 1.00 26.20 A C ATOM 1833 CE2 PHE A 122 58.221 −52.443 3.322 1.00 25.77 A C ATOM 1835 CD2 PHE A 122 57.554 −52.534 4.536 1.00 24.71 A C ATOM 1837 C PHE A 122 55.734 −54.560 8.358 1.00 26.09 A C ATOM 1838 O PHE A 122 55.717 −53.553 9.074 1.00 26.28 A O ATOM 1840 N LYS A 123 54.964 −55.622 8.587 1.00 26.57 A N ATOM 1841 CA LYS A 123 54.072 −55.719 9.745 1.00 27.02 A C ATOM 1843 CB LYS A 123 52.632 −55.359 9.349 1.00 27.12 A C ATOM 1846 CG LYS A 123 52.428 −53.873 9.013 1.00 28.30 A C ATOM 1849 CD LYS A 123 51.208 −53.615 8.116 1.00 30.27 A C ATOM 1852 CE LYS A 123 49.967 −53.187 8.895 1.00 30.83 A C ATOM 1855 NZ LYS A 123 50.115 −51.843 9.535 1.00 30.44 A N ATOM 1859 C LYS A 123 54.142 −57.139 10.313 1.00 27.21 A C ATOM 1860 O LYS A 123 54.429 −58.094 9.585 1.00 27.37 A O ATOM 1862 N ASP A 124 53.888 −57.272 11.613 1.00 27.19 A N ATOM 1863 CA ASP A 124 53.936 −58.576 12.282 1.00 26.97 A C ATOM 1865 CB ASP A 124 54.208 −58.395 13.790 1.00 26.80 A C ATOM 1868 CG ASP A 124 53.015 −57.829 14.555 1.00 26.01 A C ATOM 1869 OD1 ASP A 124 52.076 −57.288 13.930 1.00 23.03 A O ATOM 1870 OD2 ASP A 124 53.020 −57.930 15.800 1.00 25.54 A O ATOM 1871 C ASP A 124 52.647 −59.374 12.014 1.00 27.07 A C ATOM 1872 O ASP A 124 51.904 −59.059 11.079 1.00 26.95 A O ATOM 1874 N GLN A 125 52.393 −60.409 12.816 1.00 27.04 A N ATOM 1875 CA GLN A 125 51.141 −61.169 12.730 1.00 26.85 A C ATOM 1877 CB GLN A 125 51.124 −62.297 13.761 1.00 26.80 A C ATOM 1880 CG GLN A 125 52.054 −63.450 13.455 1.00 26.80 A C ATOM 1883 CD GLN A 125 51.830 −64.626 14.386 1.00 26.65 A C ATOM 1884 OE1 GLN A 125 51.287 −64.469 15.482 1.00 25.80 A O ATOM 1885 NE2 GLN A 125 52.242 −65.812 13.952 1.00 26.55 A N ATOM 1888 C GLN A 125 49.908 −60.293 12.956 1.00 26.80 A C ATOM 1889 O GLN A 125 48.889 −60.462 12.283 1.00 26.98 A O ATOM 1891 N ASN A 126 50.012 −59.369 13.910 1.00 26.46 A N ATOM 1892 CA ASN A 126 48.880 −58.542 14.337 1.00 26.12 A C ATOM 1894 CB ASN A 126 49.113 −58.030 15.762 1.00 25.97 A C ATOM 1897 CG ASN A 126 48.963 −59.117 16.804 1.00 25.81 A C ATOM 1898 OD1 ASN A 126 48.186 −58.979 17.748 1.00 26.53 A O ATOM 1899 ND2 ASN A 126 49.702 −60.209 16.637 1.00 25.44 A N ATOM 1902 C ASN A 126 48.554 −57.354 13.429 1.00 26.03 A C ATOM 1903 O ASN A 126 47.496 −56.744 13.575 1.00 26.32 A O ATOM 1905 N GLY A 127 49.445 −57.027 12.497 1.00 25.72 A N ATOM 1906 CA GLY A 127 49.262 −55.850 11.646 1.00 25.62 A C ATOM 1909 C GLY A 127 49.743 −54.571 12.316 1.00 25.62 A C ATOM 1910 O GLY A 127 49.235 −53.481 12.040 1.00 25.98 A O ATOM 1912 N ASN A 128 50.712 −54.716 13.216 1.00 25.32 A N ATOM 1913 CA ASN A 128 51.451 −53.590 13.771 1.00 24.58 A C ATOM 1915 CB ASN A 128 51.410 −53.617 15.298 1.00 24.48 A C ATOM 1918 CG ASN A 128 49.992 −53.673 15.841 1.00 24.48 A C ATOM 1919 OD1 ASN A 128 49.100 −52.975 15.355 1.00 24.27 A O ATOM 1920 ND2 ASN A 128 49.778 −54.508 16.850 1.00 23.51 A N ATOM 1923 C ASN A 128 52.881 −53.709 13.269 1.00 24.17 A C ATOM 1924 O ASN A 128 53.380 −54.819 13.064 1.00 23.94 A O ATOM 1926 N PHE A 129 53.538 −52.574 13.064 1.00 23.75 A N ATOM 1927 CA PHE A 129 54.868 −52.567 12.453 1.00 23.39 A C ATOM 1929 CB PHE A 129 55.330 −51.134 12.181 1.00 23.51 A C ATOM 1932 CG PHE A 129 54.571 −50.461 11.073 1.00 23.75 A C ATOM 1933 CD1 PHE A 129 53.351 −49.843 11.322 1.00 23.30 A C ATOM 1935 CE1 PHE A 129 52.645 −49.226 10.300 1.00 23.78 A C ATOM 1937 CZ PHE A 129 53.157 −49.223 9.011 1.00 24.34 A C ATOM 1939 CE2 PHE A 129 54.371 −49.841 8.748 1.00 24.80 A C ATOM 1941 CD2 PHE A 129 55.071 −50.456 9.777 1.00 24.15 A C ATOM 1943 C PHE A 129 55.881 −53.315 13.320 1.00 22.72 A C ATOM 1944 O PHE A 129 55.797 −53.289 14.549 1.00 22.69 A O ATOM 1946 N LEU A 130 56.821 −53.997 12.674 1.00 21.98 A N ATOM 1947 CA LEU A 130 57.774 −54.833 13.395 1.00 21.77 A C ATOM 1949 CB LEU A 130 58.741 −55.532 12.430 1.00 21.51 A C ATOM 1952 CG LEU A 130 58.233 −56.805 11.749 1.00 20.32 A C ATOM 1954 CD1 LEU A 130 59.185 −57.238 10.642 1.00 18.63 A C ATOM 1958 CD2 LEU A 130 58.049 −57.920 12.767 1.00 18.91 A C ATOM 1962 C LEU A 130 58.559 −54.008 14.406 1.00 21.98 A C ATOM 1963 O LEU A 130 59.271 −53.079 14.033 1.00 22.04 A O ATOM 1965 N GLU A 131 58.404 −54.344 15.685 1.00 22.19 A N ATOM 1966 CA GLU A 131 59.208 −53.755 16.756 1.00 22.55 A C ATOM 1968 CB GLU A 131 59.141 −54.649 18.004 1.00 22.91 A C ATOM 1971 CG GLU A 131 60.010 −54.215 19.194 1.00 23.48 A C ATOM 1974 CD GLU A 131 59.514 −52.953 19.885 1.00 24.94 A C ATOM 1975 OE1 GLU A 131 58.423 −52.451 19.536 1.00 26.88 A O ATOM 1976 OE2 GLU A 131 60.221 −52.463 20.790 1.00 25.13 A O ATOM 1977 C GLU A 131 60.659 −53.593 16.307 1.00 22.63 A C ATOM 1978 O GLU A 131 61.214 −52.497 16.355 1.00 22.79 A O ATOM 1980 N ASN A 132 61.246 −54.693 15.839 1.00 22.67 A N ATOM 1981 CA ASN A 132 62.659 −54.740 15.447 1.00 22.65 A C ATOM 1983 CB ASN A 132 63.069 −56.179 15.101 1.00 22.74 A C ATOM 1986 CG ASN A 132 62.220 −56.785 13.992 1.00 24.12 A C ATOM 1987 OD1 ASN A 132 62.359 −56.433 12.818 1.00 24.57 A O ATOM 1988 ND2 ASN A 132 61.339 −57.710 14.362 1.00 25.30 A N ATOM 1991 C ASN A 132 63.074 −53.793 14.313 1.00 22.61 A C ATOM 1992 O ASN A 132 64.266 −53.662 14.034 1.00 23.15 A O ATOM 1994 N LEU A 133 62.110 −53.141 13.661 1.00 22.44 A N ATOM 1995 CA LEU A 133 62.421 −52.087 12.682 1.00 22.59 A C ATOM 1997 CB LEU A 133 61.274 −51.905 11.677 1.00 22.57 A C ATOM 2000 CG LEU A 133 61.086 −53.023 10.646 1.00 22.37 A C ATOM 2002 CD1 LEU A 133 59.755 −52.870 9.926 1.00 20.95 A C ATOM 2006 CD2 LEU A 133 62.236 −53.049 9.647 1.00 21.48 A C ATOM 2010 C LEU A 133 62.755 −50.743 13.347 1.00 22.64 A C ATOM 2011 O LEU A 133 63.043 −49.766 12.656 1.00 22.50 A O ATOM 2013 N LYS A 134 62.710 −50.695 14.679 1.00 22.83 A N ATOM 2014 CA LYS A 134 63.148 −49.518 15.435 1.00 22.96 A C ATOM 2016 CB LYS A 134 62.736 −49.645 16.909 1.00 22.77 A C ATOM 2019 CG LYS A 134 63.555 −50.675 17.698 1.00 22.69 A C ATOM 2022 CD LYS A 134 62.959 −50.982 19.064 1.00 21.51 A C ATOM 2025 CE LYS A 134 63.861 −51.921 19.855 1.00 19.87 A C ATOM 2028 NZ LYS A 134 63.358 −52.166 21.234 1.00 19.19 A N ATOM 2032 C LYS A 134 64.667 −49.311 15.350 1.00 23.33 A C ATOM 2033 O LYS A 134 65.152 −48.189 15.500 1.00 23.47 A O ATOM 2035 N GLU A 135 65.410 −50.393 15.118 1.00 23.60 A N ATOM 2036 CA GLU A 135 66.874 −50.347 15.129 1.00 23.76 A C ATOM 2038 CB GLU A 135 67.465 −51.736 15.424 1.00 23.98 A C ATOM 2041 CG GLU A 135 66.893 −52.454 16.662 1.00 24.91 A C ATOM 2044 CD GLU A 135 67.236 −51.779 17.991 1.00 26.21 A C ATOM 2045 OE1 GLU A 135 67.594 −50.581 18.003 1.00 25.91 A O ATOM 2046 OE2 GLU A 135 67.140 −52.457 19.037 1.00 26.26 A O ATOM 2047 C GLU A 135 67.461 −49.797 13.826 1.00 23.56 A C ATOM 2048 O GLU A 135 68.641 −49.440 13.785 1.00 23.61 A O ATOM 2050 N ASP A 136 66.648 −49.739 12.770 1.00 23.07 A N ATOM 2051 CA ASP A 136 67.043 −49.103 11.511 1.00 22.73 A C ATOM 2053 CB ASP A 136 66.509 −49.903 10.315 1.00 22.88 A C ATOM 2056 CG ASP A 136 67.141 −49.489 8.990 1.00 23.31 A C ATOM 2057 OD1 ASP A 136 67.675 −48.364 8.882 1.00 24.29 A O ATOM 2058 OD2 ASP A 136 67.096 −50.301 8.043 1.00 24.88 A O ATOM 2059 C ASP A 136 66.509 −47.671 11.503 1.00 22.28 A C ATOM 2060 O ASP A 136 65.448 −47.392 10.943 1.00 22.30 A O ATOM 2062 N ILE A 137 67.263 −46.765 12.119 1.00 21.98 A N ATOM 2063 CA ILE A 137 66.813 −45.385 12.337 1.00 22.01 A C ATOM 2065 CB ILE A 137 67.780 −44.618 13.279 1.00 21.91 A C ATOM 2067 CG1 ILE A 137 67.605 −45.087 14.730 1.00 22.58 A C ATOM 2070 CD1 ILE A 137 68.188 −46.460 15.030 1.00 22.59 A C ATOM 2074 CG2 ILE A 137 67.539 −43.117 13.210 1.00 21.61 A C ATOM 2078 C ILE A 137 66.631 −44.612 11.026 1.00 22.13 A C ATOM 2079 O ILE A 137 65.838 −43.667 10.958 1.00 21.88 A O ATOM 2081 N LYS A 138 67.362 −45.025 9.992 1.00 22.24 A N ATOM 2082 CA LYS A 138 67.242 −44.431 8.659 1.00 21.88 A C ATOM 2084 CB LYS A 138 68.324 −44.994 7.727 1.00 21.96 A C ATOM 2087 CG LYS A 138 68.724 −44.056 6.601 1.00 23.45 A C ATOM 2090 CD LYS A 138 69.512 −44.788 5.522 1.00 25.55 A C ATOM 2093 CE LYS A 138 70.339 −43.831 4.674 1.00 26.38 A C ATOM 2096 NZ LYS A 138 71.460 −43.222 5.449 1.00 28.11 A N ATOM 2100 C LYS A 138 65.854 −44.689 8.062 1.00 21.05 A C ATOM 2101 O LYS A 138 65.277 −43.812 7.416 1.00 20.86 A O ATOM 2103 N ALA A 139 65.327 −45.890 8.292 1.00 20.37 A N ATOM 2104 CA ALA A 139 64.023 −46.291 7.760 1.00 19.96 A C ATOM 2106 CB ALA A 139 63.890 −47.811 7.792 1.00 19.84 A C ATOM 2110 C ALA A 139 62.856 −45.639 8.510 1.00 19.48 A C ATOM 2111 O ALA A 139 61.856 −45.256 7.897 1.00 19.09 A O ATOM 2113 N ILE A 140 62.987 −45.518 9.830 1.00 18.99 A N ATOM 2114 CA ILE A 140 61.946 −44.902 10.659 1.00 18.78 A C ATOM 2116 CB ILE A 140 62.266 −45.017 12.166 1.00 18.67 A C ATOM 2118 CG1 ILE A 140 62.385 −46.485 12.596 1.00 18.06 A C ATOM 2121 CD1 ILE A 140 61.112 −47.284 12.435 1.00 18.60 A C ATOM 2125 CG2 ILE A 140 61.194 −44.314 12.995 1.00 18.20 A C ATOM 2129 C ILE A 140 61.757 −43.420 10.306 1.00 19.04 A C ATOM 2130 O ILE A 140 60.635 −42.908 10.342 1.00 19.09 A O ATOM 2132 N LEU A 141 62.859 −42.741 9.977 1.00 18.82 A N ATOM 2133 CA LEU A 141 62.812 −41.358 9.492 1.00 18.09 A C ATOM 2135 CB LEU A 141 64.218 −40.747 9.399 1.00 17.81 A C ATOM 2138 CG LEU A 141 64.684 −39.929 10.604 1.00 17.40 A C ATOM 2140 CD1 LEU A 141 66.146 −39.540 10.452 1.00 16.73 A C ATOM 2144 CD2 LEU A 141 63.817 −38.692 10.781 1.00 16.04 A C ATOM 2148 C LEU A 141 62.129 −41.282 8.132 1.00 17.94 A C ATOM 2149 O LEU A 141 61.260 −40.440 7.917 1.00 18.26 A O ATOM 2151 N SER A 142 62.523 −42.160 7.215 1.00 17.56 A N ATOM 2152 CA SER A 142 61.894 −42.205 5.897 1.00 17.58 A C ATOM 2154 CB SER A 142 62.563 −43.246 4.998 1.00 17.71 A C ATOM 2157 OG SER A 142 63.697 −42.690 4.359 1.00 18.76 A O ATOM 2159 C SER A 142 60.401 −42.488 6.016 1.00 17.20 A C ATOM 2160 O SER A 142 59.585 −41.779 5.427 1.00 17.78 A O ATOM 2162 N LEU A 143 60.052 −43.516 6.787 1.00 16.32 A N ATOM 2163 CA LEU A 143 58.651 −43.842 7.046 1.00 15.60 A C ATOM 2165 CB LEU A 143 58.534 −45.084 7.940 1.00 15.48 A C ATOM 2168 CG LEU A 143 57.132 −45.436 8.460 1.00 14.83 A C ATOM 2170 CD1 LEU A 143 56.099 −45.438 7.342 1.00 14.92 A C ATOM 2174 CD2 LEU A 143 57.146 −46.774 9.165 1.00 14.54 A C ATOM 2178 C LEU A 143 57.929 −42.662 7.693 1.00 15.26 A C ATOM 2179 O LEU A 143 56.819 −42.316 7.292 1.00 15.30 A O ATOM 2181 N TYR A 144 58.562 −42.052 8.692 1.00 14.88 A N ATOM 2182 CA TYR A 144 57.996 −40.882 9.359 1.00 14.72 A C ATOM 2184 CB TYR A 144 58.966 −40.327 10.406 1.00 14.64 A C ATOM 2187 CG TYR A 144 58.555 −38.994 10.994 1.00 14.77 A C ATOM 2188 CD1 TYR A 144 57.598 −38.919 12.001 1.00 15.26 A C ATOM 2190 CE1 TYR A 144 57.220 −37.698 12.548 1.00 15.65 A C ATOM 2192 CZ TYR A 144 57.807 −36.534 12.091 1.00 17.33 A C ATOM 2193 OH TYR A 144 57.435 −35.321 12.629 1.00 19.54 A O ATOM 2195 CE2 TYR A 144 58.761 −36.583 11.090 1.00 17.47 A C ATOM 2197 CD2 TYR A 144 59.131 −37.809 10.550 1.00 16.29 A C ATOM 2199 C TYR A 144 57.656 −39.801 8.344 1.00 14.69 A C ATOM 2200 O TYR A 144 56.554 −39.263 8.354 1.00 14.53 A O ATOM 2202 N GLU A 145 58.605 −39.502 7.464 1.00 14.92 A N ATOM 2203 CA GLU A 145 58.428 −38.457 6.458 1.00 15.34 A C ATOM 2205 CB GLU A 145 59.725 −38.257 5.666 1.00 15.45 A C ATOM 2208 CG GLU A 145 60.888 −37.694 6.479 1.00 16.03 A C ATOM 2211 CD GLU A 145 60.742 −36.220 6.815 1.00 17.46 A C ATOM 2212 OE1 GLU A 145 59.672 −35.627 6.537 1.00 18.49 A O ATOM 2213 OE2 GLU A 145 61.709 −35.654 7.368 1.00 17.22 A O ATOM 2214 C GLU A 145 57.277 −38.759 5.493 1.00 15.41 A C ATOM 2215 O GLU A 145 56.569 −37.845 5.059 1.00 15.63 A O ATOM 2217 N ALA A 146 57.100 −40.038 5.167 1.00 15.04 A N ATOM 2218 CA ALA A 146 56.073 −40.475 4.221 1.00 14.82 A C ATOM 2220 CB ALA A 146 56.363 −41.894 3.752 1.00 14.97 A C ATOM 2224 C ALA A 146 54.665 −40.406 4.801 1.00 14.76 A C ATOM 2225 O ALA A 146 53.695 −40.297 4.056 1.00 14.65 A O ATOM 2227 N SER A 147 54.551 −40.470 6.124 1.00 14.98 A N ATOM 2228 CA SER A 147 53.245 −40.507 6.778 1.00 15.23 A C ATOM 2230 CB SER A 147 53.401 −40.795 8.271 1.00 15.04 A C ATOM 2233 OG SER A 147 53.997 −39.704 8.942 1.00 14.18 A O ATOM 2235 C SER A 147 52.457 −39.214 6.591 1.00 15.94 A C ATOM 2236 O SER A 147 51.231 −39.204 6.738 1.00 16.57 A O ATOM 2238 N PHE A 148 53.165 −38.133 6.271 1.00 16.28 A N ATOM 2239 CA PHE A 148 52.552 −36.815 6.123 1.00 16.58 A C ATOM 2241 CB PHE A 148 53.581 −35.727 6.416 1.00 16.42 A C ATOM 2244 CG PHE A 148 53.926 −35.627 7.867 1.00 17.86 A C ATOM 2245 CD1 PHE A 148 53.239 −34.753 8.694 1.00 19.24 A C ATOM 2247 CE1 PHE A 148 53.538 −34.667 10.042 1.00 19.64 A C ATOM 2249 CZ PHE A 148 54.529 −35.473 10.579 1.00 20.02 A C ATOM 2251 CE2 PHE A 148 55.214 −36.358 9.763 1.00 19.24 A C ATOM 2253 CD2 PHE A 148 54.905 −36.435 8.416 1.00 19.02 A C ATOM 2255 C PHE A 148 51.898 −36.586 4.765 1.00 16.73 A C ATOM 2256 O PHE A 148 51.078 −35.674 4.623 1.00 17.72 A O ATOM 2258 N LEU A 149 52.241 −37.416 3.780 1.00 16.12 A N ATOM 2259 CA LEU A 149 51.605 −37.353 2.461 1.00 15.65 A C ATOM 2261 CB LEU A 149 52.582 −37.802 1.368 1.00 15.36 A C ATOM 2264 CG LEU A 149 53.836 −36.939 1.206 1.00 14.18 A C ATOM 2266 CD1 LEU A 149 54.944 −37.408 2.137 1.00 13.76 A C ATOM 2270 CD2 LEU A 149 54.315 −36.957 −0.235 1.00 14.24 A C ATOM 2274 C LEU A 149 50.328 −38.200 2.405 1.00 15.63 A C ATOM 2275 O LEU A 149 49.735 −38.366 1.337 1.00 15.57 A O ATOM 2277 N ALA A 150 49.909 −38.723 3.557 1.00 15.70 A N ATOM 2278 CA ALA A 150 48.736 −39.589 3.650 1.00 15.72 A C ATOM 2280 CB ALA A 150 48.563 −40.070 5.086 1.00 15.67 A C ATOM 2284 C ALA A 150 47.456 −38.899 3.170 1.00 15.65 A C ATOM 2285 O ALA A 150 47.255 −37.706 3.404 1.00 15.79 A O ATOM 2287 N LEU A 151 46.606 −39.665 2.491 1.00 15.19 A N ATOM 2288 CA LEU A 151 45.287 −39.199 2.067 1.00 14.89 A C ATOM 2290 CB LEU A 151 44.936 −39.778 0.698 1.00 14.68 A C ATOM 2293 CG LEU A 151 45.733 −39.223 −0.478 1.00 13.02 A C ATOM 2295 CD1 LEU A 151 45.541 −40.087 −1.715 1.00 12.24 A C ATOM 2299 CD2 LEU A 151 45.311 −37.794 −0.747 1.00 12.42 A C ATOM 2303 C LEU A 151 44.241 −39.629 3.087 1.00 14.91 A C ATOM 2304 O LEU A 151 44.529 −40.431 3.976 1.00 14.52 A O ATOM 2306 N GLU A 152 43.027 −39.102 2.957 1.00 15.12 A N ATOM 2307 CA GLU A 152 41.949 −39.471 3.870 1.00 15.70 A C ATOM 2309 CB GLU A 152 40.662 −38.692 3.572 1.00 16.17 A C ATOM 2312 CG GLU A 152 40.577 −37.350 4.299 1.00 18.12 A C ATOM 2315 CD GLU A 152 39.183 −36.749 4.265 1.00 19.18 A C ATOM 2316 OE1 GLU A 152 38.686 −36.455 3.157 1.00 20.47 A O ATOM 2317 OE2 GLU A 152 38.589 −36.566 5.349 1.00 19.32 A O ATOM 2318 C GLU A 152 41.690 −40.968 3.793 1.00 15.50 A C ATOM 2319 O GLU A 152 41.623 −41.535 2.704 1.00 15.88 A O ATOM 2321 N GLY A 153 41.575 −41.602 4.957 1.00 15.25 A N ATOM 2322 CA GLY A 153 41.298 −43.033 5.039 1.00 14.87 A C ATOM 2325 C GLY A 153 42.512 −43.935 5.003 1.00 14.62 A C ATOM 2326 O GLY A 153 42.393 −45.134 5.246 1.00 14.54 A O ATOM 2328 N GLU A 154 43.680 −43.372 4.705 1.00 14.82 A N ATOM 2329 CA GLU A 154 44.907 −44.157 4.660 1.00 14.90 A C ATOM 2331 CB GLU A 154 45.957 −43.488 3.769 1.00 14.85 A C ATOM 2334 CG GLU A 154 45.527 −43.403 2.305 1.00 15.01 A C ATOM 2337 CD GLU A 154 46.681 −43.160 1.350 1.00 15.65 A C ATOM 2338 OE1 GLU A 154 46.559 −43.530 0.164 1.00 13.73 A O ATOM 2339 OE2 GLU A 154 47.712 −42.599 1.779 1.00 18.73 A O ATOM 2340 C GLU A 154 45.421 −44.359 6.079 1.00 14.88 A C ATOM 2341 O GLU A 154 46.302 −43.638 6.548 1.00 15.13 A O ATOM 2343 N ASN A 155 44.848 −45.354 6.750 1.00 14.65 A N ATOM 2344 CA ASN A 155 45.097 −45.587 8.172 1.00 14.39 A C ATOM 2346 CB ASN A 155 44.043 −46.540 8.758 1.00 14.42 A C ATOM 2349 CG ASN A 155 44.069 −47.915 8.115 1.00 14.05 A C ATOM 2350 OD1 ASN A 155 44.417 −48.059 6.946 1.00 15.53 A O ATOM 2351 ND2 ASN A 155 43.691 −48.932 8.877 1.00 14.24 A N ATOM 2354 C ASN A 155 46.499 −46.101 8.492 1.00 14.15 A C ATOM 2355 O ASN A 155 47.057 −45.750 9.530 1.00 14.42 A O ATOM 2357 N ILE A 156 47.066 −46.923 7.607 1.00 13.81 A N ATOM 2358 CA ILE A 156 48.394 −47.515 7.836 1.00 13.39 A C ATOM 2360 CB ILE A 156 48.774 −48.549 6.731 1.00 13.45 A C ATOM 2362 CG1 ILE A 156 47.886 −49.794 6.827 1.00 13.17 A C ATOM 2365 CD1 ILE A 156 48.364 −50.961 5.977 1.00 12.86 A C ATOM 2369 CG2 ILE A 156 50.234 −48.965 6.847 1.00 12.55 A C ATOM 2373 C ILE A 156 49.486 −46.447 7.955 1.00 13.02 A C ATOM 2374 O ILE A 156 50.471 −46.643 8.665 1.00 12.85 A O ATOM 2376 N LEU A 157 49.304 −45.319 7.275 1.00 12.90 A N ATOM 2377 CA LEU A 157 50.246 −44.205 7.381 1.00 12.94 A C ATOM 2379 CB LEU A 157 50.114 −43.261 6.182 1.00 12.67 A C ATOM 2382 CG LEU A 157 50.865 −43.718 4.929 1.00 11.71 A C ATOM 2384 CD1 LEU A 157 50.470 −45.129 4.540 1.00 11.58 A C ATOM 2388 CD2 LEU A 157 50.623 −42.762 3.774 1.00 12.63 A C ATOM 2392 C LEU A 157 50.078 −43.444 8.701 1.00 13.44 A C ATOM 2393 O LEU A 157 51.068 −43.039 9.308 1.00 13.49 A O ATOM 2395 N ASP A 158 48.833 −43.260 9.144 1.00 14.10 A N ATOM 2396 CA ASP A 158 48.551 −42.626 10.442 1.00 14.43 A C ATOM 2398 CB ASP A 158 47.043 −42.417 10.635 1.00 14.42 A C ATOM 2401 CG ASP A 158 46.488 −41.307 9.759 1.00 15.28 A C ATOM 2402 OD1 ASP A 158 47.035 −40.184 9.789 1.00 14.96 A O ATOM 2403 OD2 ASP A 158 45.494 −41.555 9.045 1.00 17.78 A O ATOM 2404 C ASP A 158 49.113 −43.454 11.597 1.00 14.67 A C ATOM 2405 O ASP A 158 49.622 −42.899 12.573 1.00 14.25 A O ATOM 2407 N GLU A 159 48.999 −44.778 11.476 1.00 15.29 A N ATOM 2408 CA GLU A 159 49.677 −45.723 12.370 1.00 15.67 A C ATOM 2410 CB GLU A 159 49.261 −47.160 12.052 1.00 15.79 A C ATOM 2413 CG GLU A 159 47.811 −47.499 12.324 1.00 16.58 A C ATOM 2416 CD GLU A 159 47.447 −48.900 11.846 1.00 18.81 A C ATOM 2417 OE1 GLU A 159 48.362 −49.720 11.591 1.00 17.33 A O ATOM 2418 OE2 GLU A 159 46.237 −49.182 11.725 1.00 22.11 A O ATOM 2419 C GLU A 159 51.198 −45.631 12.218 1.00 15.73 A C ATOM 2420 O GLU A 159 51.934 −45.685 13.205 1.00 15.90 A O ATOM 2422 N ALA A 160 51.656 −45.525 10.971 1.00 15.58 A N ATOM 2423 CA ALA A 160 53.082 −45.445 10.660 1.00 15.31 A C ATOM 2425 CB ALA A 160 53.297 −45.451 9.153 1.00 15.15 A C ATOM 2429 C ALA A 160 53.726 −44.210 11.276 1.00 15.28 A C ATOM 2430 O ALA A 160 54.895 −44.244 11.651 1.00 15.24 A O ATOM 2432 N LYS A 161 52.965 −43.124 11.373 1.00 15.64 A N ATOM 2433 CA LYS A 161 53.459 −41.904 11.996 1.00 16.20 A C ATOM 2435 CB LYS A 161 52.467 −40.748 11.813 1.00 16.58 A C ATOM 2438 CG LYS A 161 53.056 −39.373 12.115 1.00 17.99 A C ATOM 2441 CD LYS A 161 51.982 −38.301 12.267 1.00 19.18 A C ATOM 2444 CE LYS A 161 51.280 −38.008 10.956 1.00 20.22 A C ATOM 2447 NZ LYS A 161 50.469 −36.762 11.043 1.00 22.18 A N ATOM 2451 C LYS A 161 53.714 −42.165 13.479 1.00 16.44 A C ATOM 2452 O LYS A 161 54.843 −42.022 13.951 1.00 16.58 A O ATOM 2454 N VAL A 162 52.671 −42.579 14.197 1.00 16.53 A N ATOM 2455 CA VAL A 162 52.759 −42.814 15.645 1.00 16.48 A C ATOM 2457 CB VAL A 162 51.412 −43.299 16.237 1.00 16.23 A C ATOM 2459 CG1 VAL A 162 51.528 −43.498 17.742 1.00 16.10 A C ATOM 2463 CG2 VAL A 162 50.302 −42.307 15.923 1.00 16.13 A C ATOM 2467 C VAL A 162 53.861 −43.822 15.995 1.00 16.54 A C ATOM 2468 O VAL A 162 54.609 −43.616 16.952 1.00 16.62 A O ATOM 2470 N PHE A 163 53.955 −44.899 15.215 1.00 16.67 A N ATOM 2471 CA PHE A 163 55.011 −45.905 15.387 1.00 16.71 A C ATOM 2473 CB PHE A 163 54.803 −47.072 14.417 1.00 16.07 A C ATOM 2476 CG PHE A 163 55.907 −48.094 14.446 1.00 13.86 A C ATOM 2477 CD1 PHE A 163 55.862 −49.160 15.332 1.00 12.47 A C ATOM 2479 CE1 PHE A 163 56.880 −50.105 15.360 1.00 11.52 A C ATOM 2481 CZ PHE A 163 57.957 −49.986 14.497 1.00 10.81 A C ATOM 2483 CE2 PHE A 163 58.014 −48.928 13.610 1.00 11.67 A C ATOM 2485 CD2 PHE A 163 56.992 −47.988 13.587 1.00 12.64 A C ATOM 2487 C PHE A 163 56.406 −45.311 15.182 1.00 17.79 A C ATOM 2488 O PHE A 163 57.368 −45.724 15.838 1.00 17.93 A O ATOM 2490 N ALA A 164 56.511 −44.355 14.262 1.00 18.68 A N ATOM 2491 CA ALA A 164 57.782 −43.701 13.968 1.00 19.35 A C ATOM 2493 CB ALA A 164 57.721 −43.017 12.611 1.00 19.35 A C ATOM 2497 C ALA A 164 58.149 −42.697 15.060 1.00 19.82 A C ATOM 2498 O ALA A 164 59.254 −42.742 15.602 1.00 20.21 A O ATOM 2500 N ILE A 165 57.217 −41.803 15.383 1.00 20.14 A N ATOM 2501 CA ILE A 165 57.441 −40.775 16.404 1.00 20.35 A C ATOM 2503 CB ILE A 165 56.150 −39.959 16.698 1.00 20.49 A C ATOM 2505 CG1 ILE A 165 55.797 −39.062 15.508 1.00 20.83 A C ATOM 2508 CD1 ILE A 165 54.500 −38.292 15.676 1.00 21.96 A C ATOM 2512 CG2 ILE A 165 56.325 −39.092 17.939 1.00 20.43 A C ATOM 2516 C ILE A 165 57.949 −41.397 17.703 1.00 20.24 A C ATOM 2517 O ILE A 165 59.035 −41.062 18.173 1.00 19.62 A O ATOM 2519 N SER A 166 57.167 −42.320 18.258 1.00 20.69 A N ATOM 2520 CA SER A 166 57.470 −42.919 19.560 1.00 21.20 A C ATOM 2522 CB SER A 166 56.381 −43.923 19.958 1.00 21.36 A C ATOM 2525 OG SER A 166 56.287 −44.983 19.023 1.00 21.83 A O ATOM 2527 C SER A 166 58.846 −43.587 19.616 1.00 21.27 A C ATOM 2528 O SER A 166 59.468 −43.630 20.679 1.00 21.20 A O ATOM 2530 N HIS A 167 59.314 −44.102 18.480 1.00 21.52 A N ATOM 2531 CA HIS A 167 60.649 −44.703 18.398 1.00 21.98 A C ATOM 2533 CB HIS A 167 60.677 −45.836 17.366 1.00 22.19 A C ATOM 2536 CG HIS A 167 60.128 −47.131 17.881 1.00 23.11 A C ATOM 2537 ND1 HIS A 167 58.969 −47.696 17.395 1.00 23.65 A N ATOM 2539 CE1 HIS A 167 58.730 −48.826 18.038 1.00 24.10 A C ATOM 2541 NE2 HIS A 167 59.690 −49.012 18.926 1.00 23.55 A N ATOM 2543 CD2 HIS A 167 60.575 −47.964 18.851 1.00 23.42 A C ATOM 2545 C HIS A 167 61.748 −43.677 18.099 1.00 22.06 A C ATOM 2546 O HIS A 167 62.900 −43.884 18.480 1.00 21.93 A O ATOM 2548 N LEU A 168 61.397 −42.584 17.422 1.00 22.44 A N ATOM 2549 CA LEU A 168 62.342 −41.486 17.174 1.00 22.76 A C ATOM 2551 CB LEU A 168 61.860 −40.590 16.025 1.00 22.70 A C ATOM 2554 CG LEU A 168 61.921 −41.116 14.589 1.00 22.46 A C ATOM 2556 CD1 LEU A 168 61.482 −40.020 13.632 1.00 22.16 A C ATOM 2560 CD2 LEU A 168 63.317 −41.601 14.234 1.00 23.20 A C ATOM 2564 C LEU A 168 62.542 −40.614 18.412 1.00 23.43 A C ATOM 2565 O LEU A 168 63.648 −40.140 18.673 1.00 23.50 A O ATOM 2567 N LYS A 169 61.465 −40.408 19.165 1.00 24.25 A N ATOM 2568 CA LYS A 169 61.446 −39.435 20.259 1.00 24.95 A C ATOM 2570 CB LYS A 169 60.007 −39.234 20.749 1.00 24.99 A C ATOM 2573 CG LYS A 169 59.788 −37.951 21.533 1.00 26.38 A C ATOM 2576 CD LYS A 169 58.329 −37.522 21.493 1.00 27.59 A C ATOM 2579 CE LYS A 169 58.115 −36.206 22.217 1.00 28.00 A C ATOM 2582 NZ LYS A 169 56.702 −35.756 22.113 1.00 29.00 A N ATOM 2586 C LYS A 169 62.353 −39.802 21.438 1.00 25.45 A C ATOM 2587 O LYS A 169 62.861 −38.917 22.128 1.00 25.46 A O ATOM 2589 N GLU A 170 62.560 −41.097 21.661 1.00 26.28 A N ATOM 2590 CA GLU A 170 63.351 −41.570 22.798 1.00 27.20 A C ATOM 2592 CB GLU A 170 62.625 −42.725 23.502 1.00 27.52 A C ATOM 2595 CG GLU A 170 61.178 −42.416 23.892 1.00 29.00 A C ATOM 2598 CD GLU A 170 61.051 −41.184 24.776 1.00 30.77 A C ATOM 2599 OE1 GLU A 170 61.736 −41.127 25.821 1.00 30.80 A O ATOM 2600 OE2 GLU A 170 60.266 −40.274 24.426 1.00 31.83 A O ATOM 2601 C GLU A 170 64.756 −41.997 22.365 1.00 27.59 A C ATOM 2602 O GLU A 170 65.223 −43.086 22.715 1.00 27.53 A O ATOM 2604 N LEU A 171 65.424 −41.127 21.609 1.00 27.91 A N ATOM 2605 CA LEU A 171 66.775 −41.390 21.120 1.00 28.20 A C ATOM 2607 CB LEU A 171 66.784 −41.495 19.594 1.00 27.90 A C ATOM 2610 CG LEU A 171 65.896 −42.582 18.983 1.00 27.09 A C ATOM 2612 CD1 LEU A 171 66.044 −42.582 17.469 1.00 25.97 A C ATOM 2616 CD2 LEU A 171 66.215 −43.960 19.554 1.00 25.82 A C ATOM 2620 C LEU A 171 67.720 −40.283 21.570 1.00 28.93 A C ATOM 2621 O LEU A 171 67.390 −39.099 21.468 1.00 28.94 A O ATOM 2623 N SER A 172 68.895 −40.680 22.060 1.00 29.73 A N ATOM 2624 CA SER A 172 69.882 −39.745 22.605 1.00 30.12 A C ATOM 2626 CB SER A 172 70.465 −40.293 23.905 1.00 30.03 A C ATOM 2629 OG SER A 172 69.435 −40.707 24.783 1.00 30.49 A O ATOM 2631 C SER A 172 71.012 −39.473 21.617 1.00 30.47 A C ATOM 2632 O SER A 172 71.235 −40.241 20.678 1.00 30.80 A O ATOM 2634 N GLU A 173 71.733 −38.381 21.855 1.00 30.63 A N ATOM 2635 CA GLU A 173 72.807 −37.942 20.964 1.00 30.79 A C ATOM 2637 CB GLU A 173 73.199 −36.492 21.287 1.00 30.90 A C ATOM 2640 CG GLU A 173 73.888 −35.747 20.143 1.00 31.84 A C ATOM 2643 CD GLU A 173 73.898 −34.232 20.335 1.00 33.26 A C ATOM 2644 OE1 GLU A 173 72.839 −33.658 20.672 1.00 33.46 A O ATOM 2645 OE2 GLU A 173 74.964 −33.611 20.136 1.00 34.47 A O ATOM 2646 C GLU A 173 74.038 −38.862 21.017 1.00 30.75 A C ATOM 2647 O GLU A 173 74.807 −38.913 20.057 1.00 30.90 A O ATOM 2649 N GLU A 174 74.221 −39.585 22.125 1.00 30.65 A N ATOM 2650 CA GLU A 174 75.338 −40.532 22.262 1.00 30.58 A C ATOM 2652 CB GLU A 174 75.627 −40.857 23.733 1.00 30.55 A C ATOM 2655 CG GLU A 174 75.957 −39.663 24.614 1.00 30.63 A C ATOM 2658 CD GLU A 174 74.768 −39.198 25.430 1.00 30.50 A C ATOM 2659 OE1 GLU A 174 73.749 −38.804 24.825 1.00 29.37 A O ATOM 2660 OE2 GLU A 174 74.852 −39.230 26.675 1.00 30.66 A O ATOM 2661 C GLU A 174 75.073 −41.847 21.530 1.00 30.62 A C ATOM 2662 O GLU A 174 75.991 −42.432 20.948 1.00 30.96 A O ATOM 2664 N LYS A 175 73.822 −42.308 21.575 1.00 30.19 A N ATOM 2665 CA LYS A 175 73.443 −43.617 21.030 1.00 29.66 A C ATOM 2667 CB LYS A 175 71.983 −43.959 21.363 1.00 29.85 A C ATOM 2670 CG LYS A 175 71.603 −43.849 22.838 1.00 30.60 A C ATOM 2673 CD LYS A 175 72.325 −44.864 23.703 1.00 30.80 A C ATOM 2676 CE LYS A 175 71.987 −44.658 25.168 1.00 30.86 A C ATOM 2679 NZ LYS A 175 72.453 −45.794 26.002 1.00 31.13 A N ATOM 2683 C LYS A 175 73.628 −43.623 19.521 1.00 28.93 A C ATOM 2684 O LYS A 175 74.345 −44.461 18.973 1.00 28.70 A O ATOM 2686 N ILE A 176 72.973 −42.670 18.865 1.00 28.25 A N ATOM 2687 CA ILE A 176 73.092 −42.490 17.424 1.00 27.93 A C ATOM 2689 CB ILE A 176 71.735 −42.112 16.764 1.00 27.94 A C ATOM 2691 CG1 ILE A 176 71.039 −40.966 17.514 1.00 28.01 A C ATOM 2694 CD1 ILE A 176 69.948 −40.282 16.713 1.00 27.59 A C ATOM 2698 CG2 ILE A 176 70.822 −43.325 16.716 1.00 27.61 A C ATOM 2702 C ILE A 176 74.144 −41.421 17.143 1.00 27.68 A C ATOM 2703 O ILE A 176 74.655 −40.788 18.067 1.00 27.18 A O ATOM 2705 N GLY A 177 74.473 −41.237 15.868 1.00 27.66 A N ATOM 2706 CA GLY A 177 75.460 −40.244 15.466 1.00 27.56 A C ATOM 2709 C GLY A 177 74.987 −38.831 15.744 1.00 27.45 A C ATOM 2710 O GLY A 177 73.785 −38.552 15.719 1.00 27.69 A O ATOM 2712 N LYS A 178 75.938 −37.941 16.015 1.00 27.13 A N ATOM 2713 CA LYS A 178 75.639 −36.526 16.218 1.00 26.85 A C ATOM 2715 CB LYS A 178 76.934 −35.721 16.371 1.00 27.05 A C ATOM 2718 CG LYS A 178 76.737 −34.303 16.900 1.00 27.43 A C ATOM 2721 CD LYS A 178 78.075 −33.632 17.203 1.00 27.38 A C ATOM 2724 CE LYS A 178 77.917 −32.490 18.197 1.00 27.26 A C ATOM 2727 NZ LYS A 178 79.230 −31.954 18.642 1.00 27.88 A N ATOM 2731 C LYS A 178 74.822 −35.984 15.048 1.00 26.49 A C ATOM 2732 O LYS A 178 73.928 −35.161 15.238 1.00 26.01 A O ATOM 2734 N GLU A 179 75.130 −36.465 13.843 1.00 26.38 A N ATOM 2735 CA GLU A 179 74.427 −36.033 12.635 1.00 26.59 A C ATOM 2737 CB GLU A 179 75.284 −36.264 11.379 1.00 26.76 A C ATOM 2740 CG GLU A 179 75.652 −37.715 11.067 1.00 27.14 A C ATOM 2743 CD GLU A 179 76.355 −37.860 9.721 1.00 27.77 A C ATOM 2744 OE1 GLU A 179 76.641 −39.008 9.321 1.00 29.07 A O ATOM 2745 OE2 GLU A 179 76.623 −36.833 9.060 1.00 27.01 A O ATOM 2746 C GLU A 179 73.033 −36.657 12.469 1.00 26.24 A C ATOM 2747 O GLU A 179 72.139 −36.021 11.903 1.00 26.60 A O ATOM 2749 N LEU A 180 72.846 −37.887 12.949 1.00 25.43 A N ATOM 2750 CA LEU A 180 71.525 −38.531 12.901 1.00 24.84 A C ATOM 2752 CB LEU A 180 71.613 −40.033 13.201 1.00 24.93 A C ATOM 2755 CG LEU A 180 71.959 −40.949 12.023 1.00 25.07 A C ATOM 2757 CD1 LEU A 180 72.178 −42.374 12.519 1.00 24.77 A C ATOM 2761 CD2 LEU A 180 70.874 −40.911 10.949 1.00 23.22 A C ATOM 2765 C LEU A 180 70.549 −37.866 13.866 1.00 24.29 A C ATOM 2766 O LEU A 180 69.380 −37.671 13.531 1.00 24.25 A O ATOM 2768 N ALA A 181 71.031 −37.522 15.058 1.00 23.73 A N ATOM 2769 CA ALA A 181 70.229 −36.777 16.031 1.00 23.30 A C ATOM 2771 CB ALA A 181 71.011 −36.575 17.321 1.00 23.36 A C ATOM 2775 C ALA A 181 69.789 −35.428 15.462 1.00 22.75 A C ATOM 2776 O ALA A 181 68.650 −35.010 15.655 1.00 22.37 A O ATOM 2778 N GLU A 182 70.702 −34.758 14.762 1.00 22.59 A N ATOM 2779 CA GLU A 182 70.399 −33.493 14.088 1.00 22.35 A C ATOM 2781 CB GLU A 182 71.677 −32.858 13.517 1.00 22.71 A C ATOM 2784 CG GLU A 182 72.564 −32.200 14.578 1.00 24.48 A C ATOM 2787 CD GLU A 182 73.892 −31.690 14.031 1.00 25.90 A C ATOM 2788 OE1 GLU A 182 74.533 −32.407 13.229 1.00 26.63 A O ATOM 2789 OE2 GLU A 182 74.302 −30.573 14.418 1.00 25.24 A O ATOM 2790 C GLU A 182 69.371 −33.694 12.980 1.00 21.48 A C ATOM 2791 O GLU A 182 68.562 −32.806 12.712 1.00 21.64 A O ATOM 2793 N GLN A 183 69.408 −34.862 12.345 1.00 20.42 A N ATOM 2794 CA GLN A 183 68.426 −35.223 11.328 1.00 19.78 A C ATOM 2796 CB GLN A 183 68.890 −36.458 10.548 1.00 19.69 A C ATOM 2799 CG GLN A 183 68.480 −36.456 9.080 1.00 20.17 A C ATOM 2802 CD GLN A 183 69.261 −35.455 8.240 1.00 19.79 A C ATOM 2803 OE1 GLN A 183 68.826 −35.068 7.154 1.00 18.23 A O ATOM 2804 NE2 GLN A 183 70.419 −35.035 8.737 1.00 21.56 A N ATOM 2807 C GLN A 183 67.065 −35.499 11.973 1.00 19.19 A C ATOM 2808 O GLN A 183 66.025 −35.090 11.450 1.00 18.90 A O ATOM 2810 N VAL A 184 67.084 −36.194 13.108 1.00 18.65 A N ATOM 2811 CA VAL A 184 65.863 −36.523 13.844 1.00 18.22 A C ATOM 2813 CB VAL A 184 66.131 −37.581 14.940 1.00 18.01 A C ATOM 2815 CG1 VAL A 184 66.397 −38.935 14.306 1.00 17.80 A C ATOM 2819 CG2 VAL A 184 64.960 −37.673 15.903 1.00 17.60 A C ATOM 2823 C VAL A 184 65.237 −35.280 14.471 1.00 18.09 A C ATOM 2824 O VAL A 184 64.024 −35.091 14.389 1.00 18.22 A O ATOM 2826 N ASN A 185 66.066 −34.443 15.094 1.00 18.01 A N ATOM 2827 CA ASN A 185 65.602 −33.185 15.689 1.00 18.08 A C ATOM 2829 CB ASN A 185 66.741 −32.481 16.437 1.00 18.30 A C ATOM 2832 CG ASN A 185 67.082 −33.151 17.759 1.00 18.99 A C ATOM 2833 OD1 ASN A 185 66.855 −34.347 17.947 1.00 20.86 A O ATOM 2834 ND2 ASN A 185 67.634 −32.376 18.684 1.00 19.63 A N ATOM 2837 C ASN A 185 65.010 −32.239 14.646 1.00 18.07 A C ATOM 2838 O ASN A 185 64.042 −31.531 14.923 1.00 17.94 A O ATOM 2840 N HIS A 186 65.600 −32.235 13.453 1.00 18.13 A N ATOM 2841 CA HIS A 186 65.084 −31.459 12.322 1.00 18.18 A C ATOM 2843 CB HIS A 186 66.104 −31.468 11.180 1.00 17.97 A C ATOM 2846 CG HIS A 186 65.745 −30.580 10.028 1.00 16.43 A C ATOM 2847 ND1 HIS A 186 65.727 −29.205 10.126 1.00 14.28 A N ATOM 2849 CE1 HIS A 186 65.396 −28.688 8.956 1.00 13.38 A C ATOM 2851 NE2 HIS A 186 65.205 −29.678 8.102 1.00 14.26 A N ATOM 2853 CD2 HIS A 186 65.423 −30.871 8.746 1.00 14.62 A C ATOM 2855 C HIS A 186 63.741 −32.012 11.834 1.00 18.27 A C ATOM 2856 O HIS A 186 62.784 −31.261 11.657 1.00 18.39 A O ATOM 2858 N ALA A 187 63.679 −33.325 11.625 1.00 18.10 A N ATOM 2859 CA ALA A 187 62.454 −33.979 11.159 1.00 17.75 A C ATOM 2861 CB ALA A 187 62.726 −35.439 10.848 1.00 17.93 A C ATOM 2865 C ALA A 187 61.315 −33.859 12.173 1.00 17.45 A C ATOM 2866 O ALA A 187 60.161 −33.643 11.797 1.00 17.00 A O ATOM 2868 N LEU A 188 61.646 −33.998 13.456 1.00 17.36 A N ATOM 2869 CA LEU A 188 60.648 −33.889 14.526 1.00 17.21 A C ATOM 2871 CB LEU A 188 61.154 −34.531 15.826 1.00 16.89 A C ATOM 2874 CG LEU A 188 61.033 −36.059 15.872 1.00 16.43 A C ATOM 2876 CD1 LEU A 188 61.936 −36.663 16.933 1.00 15.33 A C ATOM 2880 CD2 LEU A 188 59.586 −36.471 16.107 1.00 16.80 A C ATOM 2884 C LEU A 188 60.216 −32.442 14.773 1.00 17.11 A C ATOM 2885 O LEU A 188 59.104 −32.205 15.245 1.00 17.54 A O ATOM 2887 N GLU A 189 61.088 −31.484 14.462 1.00 16.53 A N ATOM 2888 CA GLU A 189 60.711 −30.071 14.493 1.00 16.03 A C ATOM 2890 CB GLU A 189 61.894 −29.181 14.088 1.00 16.08 A C ATOM 2893 CG GLU A 189 61.639 −27.679 14.221 1.00 17.05 A C ATOM 2896 CD GLU A 189 62.570 −26.845 13.357 1.00 18.24 A C ATOM 2897 OE1 GLU A 189 62.631 −27.099 12.136 1.00 18.22 A O ATOM 2898 OE2 GLU A 189 63.229 −25.927 13.893 1.00 18.67 A O ATOM 2899 C GLU A 189 59.554 −29.859 13.527 1.00 15.30 A C ATOM 2900 O GLU A 189 58.502 −29.345 13.901 1.00 14.88 A O ATOM 2902 N LEU A 190 59.773 −30.280 12.284 1.00 14.95 A N ATOM 2903 CA LEU A 190 58.806 −30.145 11.203 1.00 14.48 A C ATOM 2905 CB LEU A 190 58.730 −28.685 10.740 1.00 14.32 A C ATOM 2908 CG LEU A 190 57.637 −28.308 9.735 1.00 13.70 A C ATOM 2910 CD1 LEU A 190 56.257 −28.398 10.377 1.00 12.88 A C ATOM 2914 CD2 LEU A 190 57.885 −26.909 9.175 1.00 9.41 A C ATOM 2918 C LEU A 190 59.281 −31.037 10.057 1.00 14.33 A C ATOM 2919 O LEU A 190 60.460 −31.011 9.711 1.00 14.00 A O ATOM 2921 N PRO A 191 58.379 −31.839 9.468 1.00 14.65 A N ATOM 2922 CA PRO A 191 58.827 −32.779 8.437 1.00 14.74 A C ATOM 2924 CB PRO A 191 57.674 −33.777 8.358 1.00 14.70 A C ATOM 2927 CG PRO A 191 56.473 −32.971 8.707 1.00 15.26 A C ATOM 2930 CD PRO A 191 56.918 −31.887 9.655 1.00 14.91 A C ATOM 2933 C PRO A 191 59.059 −32.111 7.082 1.00 14.61 A C ATOM 2934 O PRO A 191 58.725 −30.941 6.903 1.00 15.11 A O ATOM 2935 N LEU A 192 59.624 −32.860 6.142 1.00 14.26 A N ATOM 2936 CA LEU A 192 59.935 −32.339 4.814 1.00 13.99 A C ATOM 2938 CB LEU A 192 60.580 −33.424 3.950 1.00 14.19 A C ATOM 2941 CG LEU A 192 61.980 −33.866 4.391 1.00 16.27 A C ATOM 2943 CD1 LEU A 192 62.353 −35.200 3.765 1.00 17.03 A C ATOM 2947 CD2 LEU A 192 63.019 −32.803 4.053 1.00 17.29 A C ATOM 2951 C LEU A 192 58.688 −31.817 4.122 1.00 13.36 A C ATOM 2952 O LEU A 192 58.662 −30.679 3.661 1.00 13.23 A O ATOM 2954 N HIS A 193 57.651 −32.649 4.086 1.00 13.28 A N ATOM 2955 CA HIS A 193 56.421 −32.355 3.343 1.00 13.38 A C ATOM 2957 CB HIS A 193 55.449 −33.537 3.458 1.00 13.14 A C ATOM 2960 CG HIS A 193 54.224 −33.402 2.608 1.00 12.08 A C ATOM 2961 ND1 HIS A 193 54.279 −33.279 1.237 1.00 11.82 A N ATOM 2963 CE1 HIS A 193 53.053 −33.178 0.757 1.00 11.83 A C ATOM 2965 NE2 HIS A 193 52.204 −33.235 1.767 1.00 9.95 A N ATOM 2967 CD2 HIS A 193 52.910 −33.375 2.936 1.00 10.22 A C ATOM 2969 C HIS A 193 55.722 −31.055 3.764 1.00 13.92 A C ATOM 2970 O HIS A 193 54.964 −30.478 2.979 1.00 13.67 A O ATOM 2972 N ARG A 194 55.971 −30.598 4.989 1.00 14.56 A N ATOM 2973 CA ARG A 194 55.393 −29.343 5.475 1.00 15.25 A C ATOM 2975 CB ARG A 194 54.749 −29.557 6.843 1.00 15.26 A C ATOM 2978 CG ARG A 194 53.625 −30.571 6.824 1.00 16.11 A C ATOM 2981 CD ARG A 194 52.888 −30.620 8.150 1.00 18.42 A C ATOM 2984 NE ARG A 194 51.885 −31.684 8.170 1.00 19.85 A N ATOM 2986 CZ ARG A 194 51.170 −32.042 9.236 1.00 20.13 A C ATOM 2987 NH1 ARG A 194 51.330 −31.431 10.406 1.00 21.48 A N ATOM 2990 NH2 ARG A 194 50.288 −33.028 9.132 1.00 20.98 A N ATOM 2993 C ARG A 194 56.392 −28.180 5.542 1.00 15.65 A C ATOM 2994 O ARG A 194 55.981 −27.029 5.629 1.00 16.13 A O ATOM 2996 N ARG A 195 57.691 −28.468 5.501 1.00 15.83 A N ATOM 2997 CA ARG A 195 58.707 −27.416 5.544 1.00 15.92 A C ATOM 2999 CB ARG A 195 60.047 −27.994 5.992 1.00 16.22 A C ATOM 3002 CG ARG A 195 61.069 −26.938 6.388 1.00 18.02 A C ATOM 3005 CD ARG A 195 62.434 −27.540 6.681 1.00 18.19 A C ATOM 3008 NE ARG A 195 62.382 −28.612 7.672 1.00 19.14 A N ATOM 3010 CZ ARG A 195 62.233 −28.434 8.984 1.00 21.01 A C ATOM 3011 NH1 ARG A 195 62.104 −27.216 9.507 1.00 20.62 A N ATOM 3014 NH2 ARG A 195 62.212 −29.490 9.788 1.00 22.42 A N ATOM 3017 C ARG A 195 58.866 −26.768 4.171 1.00 15.95 A C ATOM 3018 O ARG A 195 58.929 −27.471 3.158 1.00 15.90 A O ATOM 3020 N THR A 196 58.946 −25.436 4.133 1.00 15.87 A N ATOM 3021 CA THR A 196 59.146 −24.725 2.866 1.00 15.91 A C ATOM 3023 CB THR A 196 59.126 −23.183 3.019 1.00 15.61 A C ATOM 3025 OG1 THR A 196 60.106 −22.770 3.979 1.00 15.28 A O ATOM 3027 CG2 THR A 196 57.757 −22.700 3.452 1.00 15.63 A C ATOM 3031 C THR A 196 60.468 −25.151 2.236 1.00 16.35 A C ATOM 3032 O THR A 196 61.379 −25.611 2.928 1.00 16.39 A O ATOM 3034 N GLN A 197 60.562 −24.986 0.922 1.00 16.60 A N ATOM 3035 CA GLN A 197 61.675 −25.537 0.147 1.00 16.65 A C ATOM 3037 CB GLN A 197 61.292 −25.578 −1.344 1.00 16.83 A C ATOM 3040 CG GLN A 197 62.268 −24.945 −2.318 1.00 18.46 A C ATOM 3043 CD GLN A 197 63.359 −25.875 −2.795 1.00 19.11 A C ATOM 3044 OE1 GLN A 197 64.519 −25.716 −2.426 1.00 18.91 A O ATOM 3045 NE2 GLN A 197 62.997 −26.839 −3.639 1.00 19.88 A N ATOM 3048 C GLN A 197 63.023 −24.834 0.399 1.00 16.45 A C ATOM 3049 O GLN A 197 64.073 −25.476 0.344 1.00 16.57 A O ATOM 3051 N ARG A 198 62.990 −23.535 0.692 1.00 16.22 A N ATOM 3052 CA ARG A 198 64.219 −22.767 0.939 1.00 15.80 A C ATOM 3054 CB ARG A 198 63.960 −21.270 0.758 1.00 15.86 A C ATOM 3057 CG ARG A 198 63.690 −20.856 −0.682 1.00 16.65 A C ATOM 3060 CD ARG A 198 64.967 −20.804 −1.526 1.00 16.78 A C ATOM 3063 NE ARG A 198 65.295 −22.072 −2.175 1.00 16.13 A N ATOM 3065 CZ ARG A 198 66.289 −22.234 −3.048 1.00 18.48 A C ATOM 3066 NH1 ARG A 198 67.067 −21.209 −3.393 1.00 17.78 A N ATOM 3069 NH2 ARG A 198 66.511 −23.431 −3.585 1.00 19.12 A N ATOM 3072 C ARG A 198 64.819 −23.027 2.324 1.00 15.17 A C ATOM 3073 O ARG A 198 66.032 −23.193 2.452 1.00 14.96 A O ATOM 3075 N LEU A 199 63.974 −23.051 3.354 1.00 14.66 A N ATOM 3076 CA LEU A 199 64.425 −23.342 4.719 1.00 14.28 A C ATOM 3078 CB LEU A 199 63.290 −23.155 5.738 1.00 14.42 A C ATOM 3081 CG LEU A 199 62.996 −21.723 6.198 1.00 13.58 A C ATOM 3083 CD1 LEU A 199 64.225 −21.108 6.838 1.00 12.91 A C ATOM 3087 CD2 LEU A 199 61.823 −21.698 7.166 1.00 11.52 A C ATOM 3091 C LEU A 199 64.973 −24.760 4.820 1.00 13.99 A C ATOM 3092 O LEU A 199 65.941 −25.007 5.542 1.00 13.43 A O ATOM 3094 N GLU A 200 64.338 −25.686 4.105 1.00 13.99 A N ATOM 3095 CA GLU A 200 64.840 −27.052 3.993 1.00 14.04 A C ATOM 3097 CB GLU A 200 63.833 −27.945 3.254 1.00 14.26 A C ATOM 3100 CG GLU A 200 64.284 −29.393 3.026 1.00 15.07 A C ATOM 3103 CD GLU A 200 64.864 −30.053 4.267 1.00 16.59 A C ATOM 3104 OE1 GLU A 200 64.228 −29.992 5.341 1.00 18.96 A O ATOM 3105 OE2 GLU A 200 65.957 −30.646 4.165 1.00 16.21 A O ATOM 3106 C GLU A 200 66.176 −27.051 3.263 1.00 13.82 A C ATOM 3107 O GLU A 200 67.090 −27.786 3.640 1.00 14.49 A O ATOM 3109 N ALA A 201 66.283 −26.220 2.226 1.00 13.15 A N ATOM 3110 CA ALA A 201 67.510 −26.108 1.437 1.00 12.65 A C ATOM 3112 CB ALA A 201 67.272 −25.238 0.221 1.00 12.47 A C ATOM 3116 C ALA A 201 68.696 −25.576 2.249 1.00 12.48 A C ATOM 3117 O ALA A 201 69.755 −26.200 2.272 1.00 12.06 A O ATOM 3119 N VAL A 202 68.515 −24.439 2.922 1.00 12.67 A N ATOM 3120 CA VAL A 202 69.609 −23.801 3.673 1.00 12.57 A C ATOM 3122 CB VAL A 202 69.196 −22.440 4.277 1.00 12.42 A C ATOM 3124 CG1 VAL A 202 68.324 −22.635 5.506 1.00 12.80 A C ATOM 3128 CG2 VAL A 202 70.426 −21.626 4.635 1.00 12.02 A C ATOM 3132 C VAL A 202 70.130 −24.682 4.800 1.00 12.80 A C ATOM 3133 O VAL A 202 71.296 −24.580 5.176 1.00 12.89 A O ATOM 3135 N TRP A 203 69.261 −25.537 5.336 1.00 13.26 A N ATOM 3136 CA TRP A 203 69.638 −26.478 6.385 1.00 13.35 A C ATOM 3138 CB TRP A 203 68.399 −26.965 7.140 1.00 13.36 A C ATOM 3141 CG TRP A 203 68.720 −27.817 8.329 1.00 12.25 A C ATOM 3142 CD1 TRP A 203 68.960 −27.387 9.601 1.00 12.59 A C ATOM 3144 NE1 TRP A 203 69.219 −28.456 10.421 1.00 11.51 A N ATOM 3146 CE2 TRP A 203 69.152 −29.607 9.683 1.00 10.81 A C ATOM 3147 CD2 TRP A 203 68.837 −29.242 8.358 1.00 11.23 A C ATOM 3148 CE3 TRP A 203 68.706 −30.247 7.393 1.00 12.78 A C ATOM 3150 CZ3 TRP A 203 68.893 −31.567 7.778 1.00 12.64 A C ATOM 3152 CH2 TRP A 203 69.205 −31.897 9.107 1.00 11.26 A C ATOM 3154 CZ2 TRP A 203 69.339 −30.934 10.069 1.00 10.95 A C ATOM 3156 C TRP A 203 70.379 −27.670 5.795 1.00 13.47 A C ATOM 3157 O TRP A 203 71.515 −27.954 6.183 1.00 13.39 A O ATOM 3159 N SER A 204 69.730 −28.355 4.852 1.00 13.61 A N ATOM 3160 CA SER A 204 70.270 −29.589 4.263 1.00 13.87 A C ATOM 3162 CB SER A 204 69.323 −30.142 3.194 1.00 13.67 A C ATOM 3165 OG SER A 204 68.234 −30.819 3.792 1.00 13.52 A O ATOM 3167 C SER A 204 71.666 −29.407 3.674 1.00 14.22 A C ATOM 3168 O SER A 204 72.476 −30.333 3.708 1.00 14.33 A O ATOM 3170 N ILE A 205 71.933 −28.216 3.139 1.00 14.32 A N ATOM 3171 CA ILE A 205 73.259 −27.852 2.639 1.00 14.23 A C ATOM 3173 CB ILE A 205 73.234 −26.458 1.967 1.00 14.07 A C ATOM 3175 CG1 ILE A 205 72.473 −26.517 0.643 1.00 13.44 A C ATOM 3178 CD1 ILE A 205 72.074 −25.161 0.117 1.00 12.73 A C ATOM 3182 CG2 ILE A 205 74.647 −25.947 1.718 1.00 15.49 A C ATOM 3186 C ILE A 205 74.292 −27.845 3.769 1.00 14.47 A C ATOM 3187 O ILE A 205 75.347 −28.479 3.663 1.00 14.24 A O ATOM 3189 N GLU A 206 73.975 −27.126 4.846 1.00 14.66 A N ATOM 3190 CA GLU A 206 74.842 −27.051 6.023 1.00 14.82 A C ATOM 3192 CB GLU A 206 74.219 −26.131 7.082 1.00 15.15 A C ATOM 3195 CG GLU A 206 75.064 −25.916 8.346 1.00 16.59 A C ATOM 3198 CD GLU A 206 76.420 −25.279 8.071 1.00 17.90 A C ATOM 3199 OE1 GLU A 206 76.582 −24.629 7.014 1.00 19.11 A O ATOM 3200 OE2 GLU A 206 77.325 −25.424 8.922 1.00 18.61 A O ATOM 3201 C GLU A 206 75.094 −28.436 6.616 1.00 14.53 A C ATOM 3202 O GLU A 206 76.197 −28.730 7.072 1.00 14.36 A O ATOM 3204 N ALA A 207 74.063 −29.277 6.604 1.00 14.37 A N ATOM 3205 CA ALA A 207 74.173 −30.655 7.079 1.00 14.14 A C ATOM 3207 CB ALA A 207 72.785 −31.266 7.234 1.00 14.13 A C ATOM 3211 C ALA A 207 75.015 −31.514 6.141 1.00 13.78 A C ATOM 3212 O ALA A 207 75.898 −32.248 6.585 1.00 13.22 A O ATOM 3214 N TYR A 208 74.733 −31.410 4.845 1.00 13.95 A N ATOM 3215 CA TYR A 208 75.319 −32.297 3.838 1.00 14.17 A C ATOM 3217 CB TYR A 208 74.531 −32.189 2.525 1.00 14.20 A C ATOM 3220 CG TYR A 208 74.881 −33.219 1.471 1.00 13.85 A C ATOM 3221 CD1 TYR A 208 74.401 −34.523 1.557 1.00 15.48 A C ATOM 3223 CE1 TYR A 208 74.710 −35.472 0.583 1.00 15.09 A C ATOM 3225 CZ TYR A 208 75.500 −35.115 −0.494 1.00 13.90 A C ATOM 3226 OH TYR A 208 75.811 −36.045 −1.458 1.00 11.21 A O ATOM 3228 CE2 TYR A 208 75.984 −33.823 −0.604 1.00 14.12 A C ATOM 3230 CD2 TYR A 208 75.670 −32.882 0.375 1.00 13.38 A C ATOM 3232 C TYR A 208 76.804 −32.031 3.588 1.00 14.31 A C ATOM 3233 O TYR A 208 77.515 −32.918 3.120 1.00 14.93 A O ATOM 3235 N ARG A 209 77.276 −30.825 3.892 1.00 14.14 A N ATOM 3236 CA ARG A 209 78.691 −30.508 3.698 1.00 14.20 A C ATOM 3238 CB ARG A 209 78.912 −28.994 3.580 1.00 14.05 A C ATOM 3241 CG ARG A 209 78.753 −28.202 4.872 1.00 14.18 A C ATOM 3244 CD ARG A 209 79.424 −26.841 4.766 1.00 14.24 A C ATOM 3247 NE ARG A 209 78.659 −25.905 3.944 1.00 13.50 A N ATOM 3249 CZ ARG A 209 79.136 −24.767 3.440 1.00 12.08 A C ATOM 3250 NH1 ARG A 209 80.397 −24.399 3.650 1.00 10.79 A N ATOM 3253 NH2 ARG A 209 78.343 −23.991 2.710 1.00 12.81 A N ATOM 3256 C ARG A 209 79.571 −31.108 4.802 1.00 14.55 A C ATOM 3257 O ARG A 209 80.767 −31.309 4.600 1.00 14.80 A O ATOM 3259 N LYS A 210 78.977 −31.388 5.960 1.00 15.15 A N ATOM 3260 CA LYS A 210 79.694 −32.011 7.076 1.00 15.61 A C ATOM 3262 CB LYS A 210 79.018 −31.669 8.406 1.00 15.61 A C ATOM 3265 CG LYS A 210 78.981 −30.177 8.719 1.00 15.58 A C ATOM 3268 CD LYS A 210 78.026 −29.867 9.865 1.00 15.71 A C ATOM 3271 CE LYS A 210 77.856 −28.368 10.057 1.00 15.97 A C ATOM 3274 NZ LYS A 210 76.875 −28.038 11.131 1.00 15.56 A N ATOM 3278 C LYS A 210 79.795 −33.531 6.911 1.00 16.30 A C ATOM 3279 O LYS A 210 80.599 −34.176 7.584 1.00 16.27 A O ATOM 3281 N LYS A 211 78.972 −34.104 6.033 1.00 17.15 A N ATOM 3282 CA LYS A 211 79.141 −35.496 5.628 1.00 17.96 A C ATOM 3284 CB LYS A 211 78.049 −35.934 4.644 1.00 18.23 A C ATOM 3287 CG LYS A 211 76.694 −36.253 5.260 1.00 19.44 A C ATOM 3290 CD LYS A 211 75.846 −37.071 4.282 1.00 21.73 A C ATOM 3293 CE LYS A 211 74.424 −37.282 4.784 1.00 23.25 A C ATOM 3296 NZ LYS A 211 74.388 −38.036 6.071 1.00 24.71 A N ATOM 3300 C LYS A 211 80.499 −35.635 4.952 1.00 18.46 A C ATOM 3301 O LYS A 211 80.739 −35.015 3.915 1.00 18.58 A O ATOM 3303 N GLU A 212 81.383 −36.442 5.534 1.00 19.08 A N ATOM 3304 CA GLU A 212 82.726 −36.640 4.975 1.00 19.70 A C ATOM 3306 CB GLU A 212 83.607 −37.453 5.936 1.00 20.07 A C ATOM 3309 CG GLU A 212 85.113 −37.304 5.683 1.00 20.44 A C ATOM 3312 CD GLU A 212 85.953 −38.339 6.423 1.00 20.22 A C ATOM 3313 OE1 GLU A 212 86.981 −37.951 7.016 1.00 19.88 A O ATOM 3314 OE2 GLU A 212 85.595 −39.538 6.407 1.00 18.93 A O ATOM 3315 C GLU A 212 82.667 −37.328 3.606 1.00 19.59 A C ATOM 3316 O GLU A 212 83.540 −37.119 2.763 1.00 19.49 A O ATOM 3318 N ASP A 213 81.627 −38.133 3.393 1.00 19.59 A N ATOM 3319 CA ASP A 213 81.420 −38.841 2.128 1.00 19.85 A C ATOM 3321 CB ASP A 213 80.904 −40.262 2.404 1.00 20.37 A C ATOM 3324 CG ASP A 213 79.566 −40.272 3.132 1.00 22.19 A C ATOM 3325 OD1 ASP A 213 79.448 −39.595 4.178 1.00 23.92 A O ATOM 3326 OD2 ASP A 213 78.636 −40.959 2.660 1.00 25.96 A O ATOM 3327 C ASP A 213 80.452 −38.100 1.194 1.00 19.34 A C ATOM 3328 O ASP A 213 79.764 −38.723 0.383 1.00 19.04 A O ATOM 3330 N ALA A 214 80.412 −36.773 1.299 1.00 19.11 A N ATOM 3331 CA ALA A 214 79.501 −35.959 0.496 1.00 19.01 A C ATOM 3333 CB ALA A 214 79.366 −34.570 1.099 1.00 18.73 A C ATOM 3337 C ALA A 214 79.984 −35.857 −0.946 1.00 19.16 A C ATOM 3338 O ALA A 214 81.188 −35.779 −1.198 1.00 19.39 A O ATOM 3340 N ASN A 215 79.040 −35.860 −1.885 1.00 19.33 A N ATOM 3341 CA ASN A 215 79.354 −35.675 −3.302 1.00 19.51 A C ATOM 3343 CB ASN A 215 78.184 −36.142 −4.182 1.00 19.77 A C ATOM 3346 CG ASN A 215 78.595 −36.396 −5.628 1.00 20.67 A C ATOM 3347 OD1 ASN A 215 78.874 −35.463 −6.383 1.00 22.18 A O ATOM 3348 ND2 ASN A 215 78.623 −37.666 −6.019 1.00 20.55 A N ATOM 3351 C ASN A 215 79.683 −34.202 −3.564 1.00 19.05 A C ATOM 3352 O ASN A 215 78.819 −33.333 −3.428 1.00 19.14 A O ATOM 3354 N GLN A 216 80.934 −33.932 −3.932 1.00 18.33 A N ATOM 3355 CA GLN A 216 81.424 −32.558 −4.070 1.00 17.80 A C ATOM 3357 CB GLN A 216 82.943 −32.536 −4.292 1.00 17.98 A C ATOM 3360 CG GLN A 216 83.771 −33.244 −3.213 1.00 19.00 A C ATOM 3363 CD GLN A 216 83.465 −32.763 −1.804 1.00 19.26 A C ATOM 3364 OE1 GLN A 216 83.323 −31.565 −1.560 1.00 18.93 A O ATOM 3365 NE2 GLN A 216 83.369 −33.701 −0.868 1.00 19.47 A N ATOM 3368 C GLN A 216 80.735 −31.814 −5.208 1.00 17.08 A C ATOM 3369 O GLN A 216 80.432 −30.627 −5.080 1.00 17.09 A O ATOM 3371 N VAL A 217 80.490 −32.511 −6.315 1.00 16.33 A N ATOM 3372 CA VAL A 217 79.826 −31.912 −7.474 1.00 15.80 A C ATOM 3374 CB VAL A 217 79.755 −32.894 −8.668 1.00 15.84 A C ATOM 3376 CG1 VAL A 217 78.935 −32.298 −9.809 1.00 14.63 A C ATOM 3380 CG2 VAL A 217 81.155 −33.254 −9.147 1.00 16.01 A C ATOM 3384 C VAL A 217 78.411 −31.454 −7.123 1.00 15.46 A C ATOM 3385 O VAL A 217 77.999 −30.355 −7.500 1.00 15.60 A O ATOM 3387 N LEU A 218 77.680 −32.296 −6.395 1.00 14.90 A N ATOM 3388 CA LEU A 218 76.300 −31.998 −6.009 1.00 14.22 A C ATOM 3390 CB LEU A 218 75.629 −33.247 −5.428 1.00 13.96 A C ATOM 3393 CG LEU A 218 74.139 −33.142 −5.094 1.00 13.06 A C ATOM 3395 CD1 LEU A 218 73.337 −32.809 −6.334 1.00 12.25 A C ATOM 3399 CD2 LEU A 218 73.641 −34.437 −4.469 1.00 13.26 A C ATOM 3403 C LEU A 218 76.223 −30.849 −5.003 1.00 14.10 A C ATOM 3404 O LEU A 218 75.312 −30.020 −5.072 1.00 14.58 A O ATOM 3406 N LEU A 219 77.176 −30.810 −4.071 1.00 13.33 A N ATOM 3407 CA LEU A 219 77.232 −29.759 −3.054 1.00 12.42 A C ATOM 3409 CB LEU A 219 78.290 −30.088 −1.996 1.00 12.57 A C ATOM 3412 CG LEU A 219 78.579 −29.028 −0.926 1.00 12.20 A C ATOM 3414 CD1 LEU A 219 77.303 −28.587 −0.229 1.00 11.68 A C ATOM 3418 CD2 LEU A 219 79.581 −29.562 0.083 1.00 11.55 A C ATOM 3422 C LEU A 219 77.548 −28.415 −3.687 1.00 11.77 A C ATOM 3423 O LEU A 219 76.797 −27.456 −3.523 1.00 11.68 A O ATOM 3425 N GLU A 220 78.664 −28.358 −4.411 1.00 11.19 A N ATOM 3426 CA GLU A 220 79.099 −27.132 −5.084 1.00 10.73 A C ATOM 3428 CB GLU A 220 80.281 −27.414 −6.019 1.00 10.70 A C ATOM 3431 CG GLU A 220 80.927 −26.162 −6.616 1.00 11.19 A C ATOM 3434 CD GLU A 220 82.256 −26.444 −7.314 1.00 12.55 A C ATOM 3435 OE1 GLU A 220 82.631 −27.630 −7.453 1.00 13.13 A O ATOM 3436 OE2 GLU A 220 82.929 −25.473 −7.724 1.00 12.14 A O ATOM 3437 C GLU A 220 77.950 −26.501 −5.862 1.00 10.27 A C ATOM 3438 O GLU A 220 77.748 −25.292 −5.793 1.00 10.52 A O ATOM 3440 N LEU A 221 77.194 −27.325 −6.584 1.00 9.55 A N ATOM 3441 CA LEU A 221 76.018 −26.851 −7.310 1.00 9.02 A C ATOM 3443 CB LEU A 221 75.442 −27.966 −8.186 1.00 8.70 A C ATOM 3446 CG LEU A 221 74.258 −27.599 −9.086 1.00 7.05 A C ATOM 3448 CD1 LEU A 221 74.630 −26.491 −10.059 1.00 2.00 A C ATOM 3452 CD2 LEU A 221 73.772 −28.833 −9.831 1.00 6.26 A C ATOM 3456 C LEU A 221 74.948 −26.343 −6.347 1.00 9.08 A C ATOM 3457 O LEU A 221 74.395 −25.262 −6.544 1.00 8.80 A O ATOM 3459 N ALA A 222 74.669 −27.124 −5.305 1.00 9.46 A N ATOM 3460 CA ALA A 222 73.666 −26.757 −4.301 1.00 9.95 A C ATOM 3462 CB ALA A 222 73.633 −27.794 −3.181 1.00 9.71 A C ATOM 3466 C ALA A 222 73.913 −25.358 −3.728 1.00 10.24 A C ATOM 3467 O ALA A 222 72.979 −24.572 −3.572 1.00 10.55 A O ATOM 3469 N ILE A 223 75.173 −25.055 −3.430 1.00 10.52 A N ATOM 3470 CA ILE A 223 75.562 −23.737 −2.925 1.00 10.83 A C ATOM 3472 CB ILE A 223 77.049 −23.711 −2.476 1.00 10.98 A C ATOM 3474 CG1 ILE A 223 77.305 −24.712 −1.345 1.00 11.58 A C ATOM 3477 CD1 ILE A 223 78.778 −24.910 −1.045 1.00 12.62 A C ATOM 3481 CG2 ILE A 223 77.451 −22.315 −2.019 1.00 9.71 A C ATOM 3485 C ILE A 223 75.374 −22.683 −4.016 1.00 11.05 A C ATOM 3486 O ILE A 223 74.722 −21.656 −3.800 1.00 10.83 A O ATOM 3488 N LEU A 224 75.955 −22.958 −5.183 1.00 11.18 A N ATOM 3489 CA LEU A 224 75.918 −22.044 −6.328 1.00 11.07 A C ATOM 3491 CB LEU A 224 76.648 −22.654 −7.534 1.00 11.14 A C ATOM 3494 CG LEU A 224 78.143 −22.340 −7.658 1.00 11.66 A C ATOM 3496 CD1 LEU A 224 78.746 −23.108 −8.827 1.00 11.34 A C ATOM 3500 CD2 LEU A 224 78.905 −22.632 −6.369 1.00 11.95 A C ATOM 3504 C LEU A 224 74.500 −21.660 −6.730 1.00 10.85 A C ATOM 3505 O LEU A 224 74.239 −20.497 −7.035 1.00 10.84 A O ATOM 3507 N ASP A 225 73.593 −22.635 −6.727 1.00 10.80 A N ATOM 3508 CA ASP A 225 72.207 −22.395 −7.125 1.00 10.89 A C ATOM 3510 CB ASP A 225 71.505 −23.705 −7.481 1.00 10.48 A C ATOM 3513 CG ASP A 225 70.158 −23.481 −8.142 1.00 9.49 A C ATOM 3514 OD1 ASP A 225 69.184 −23.189 −7.422 1.00 10.17 A O ATOM 3515 OD2 ASP A 225 70.069 −23.597 −9.382 1.00 8.04 A O ATOM 3516 C ASP A 225 71.416 −21.659 −6.047 1.00 11.49 A C ATOM 3517 O ASP A 225 70.605 −20.792 −6.367 1.00 11.55 A O ATOM 3519 N TYR A 226 71.641 −22.004 −4.780 1.00 12.19 A N ATOM 3520 CA TYR A 226 70.963 −21.320 −3.676 1.00 12.94 A C ATOM 3522 CB TYR A 226 71.215 −22.022 −2.335 1.00 13.18 A C ATOM 3525 CG TYR A 226 70.495 −21.360 −1.178 1.00 13.58 A C ATOM 3526 CD1 TYR A 226 69.207 −21.745 −0.825 1.00 15.76 A C ATOM 3528 CE1 TYR A 226 68.536 −21.133 0.227 1.00 17.41 A C ATOM 3530 CZ TYR A 226 69.154 −20.117 0.932 1.00 18.41 A C ATOM 3531 OH TYR A 226 68.493 −19.509 1.972 1.00 18.87 A O ATOM 3533 CE2 TYR A 226 70.434 −19.712 0.595 1.00 16.75 A C ATOM 3535 CD2 TYR A 226 71.093 −20.331 −0.457 1.00 14.36 A C ATOM 3537 C TYR A 226 71.394 −19.855 −3.582 1.00 13.23 A C ATOM 3538 O TYR A 226 70.562 −18.971 −3.355 1.00 13.29 A O ATOM 3540 N ASN A 227 72.692 −19.608 −3.742 1.00 13.39 A N ATOM 3541 CA ASN A 227 73.221 −18.246 −3.718 1.00 14.03 A C ATOM 3543 CB ASN A 227 74.751 −18.258 −3.625 1.00 14.09 A C ATOM 3546 CG ASN A 227 75.255 −18.679 −2.250 1.00 14.19 A C ATOM 3547 OD1 ASN A 227 74.571 −18.512 −1.241 1.00 14.72 A O ATOM 3548 ND2 ASN A 227 76.467 −19.217 −2.208 1.00 15.25 A N ATOM 3551 C ASN A 227 72.768 −17.429 −4.929 1.00 14.55 A C ATOM 3552 O ASN A 227 72.560 −16.219 −4.819 1.00 14.82 A O ATOM 3554 N MET A 228 72.619 −18.093 −6.074 1.00 14.98 A N ATOM 3555 CA MET A 228 72.085 −17.462 −7.284 1.00 15.29 A C ATOM 3557 CB MET A 228 72.127 −18.444 −8.462 1.00 15.61 A C ATOM 3560 CG MET A 228 71.507 −17.933 −9.767 1.00 16.18 A C ATOM 3563 SD MET A 228 70.987 −19.279 −10.861 1.00 18.75 A S ATOM 3564 CE MET A 228 69.510 −19.868 −10.029 1.00 17.19 A C ATOM 3568 C MET A 228 70.650 −17.009 −7.049 1.00 15.29 A C ATOM 3569 O MET A 228 70.329 −15.833 −7.218 1.00 15.27 A O ATOM 3571 N ILE A 229 69.793 −17.951 −6.661 1.00 15.43 A N ATOM 3572 CA ILE A 229 68.385 −17.655 −6.413 1.00 15.53 A C ATOM 3574 CB ILE A 229 67.605 −18.896 −5.916 1.00 15.48 A C ATOM 3576 CG1 ILE A 229 67.419 −19.909 −7.051 1.00 15.09 A C ATOM 3579 CD1 ILE A 229 66.660 −21.167 −6.643 1.00 11.04 A C ATOM 3583 CG2 ILE A 229 66.240 −18.489 −5.384 1.00 16.76 A C ATOM 3587 C ILE A 229 68.252 −16.529 −5.395 1.00 15.81 A C ATOM 3588 O ILE A 229 67.429 −15.634 −5.566 1.00 16.48 A O ATOM 3590 N GLN A 230 69.073 −16.567 −4.348 1.00 15.87 A N ATOM 3591 CA GLN A 230 69.059 −15.514 −3.332 1.00 15.81 A C ATOM 3593 CB GLN A 230 70.046 −15.817 −2.199 1.00 15.91 A C ATOM 3596 CG GLN A 230 69.925 −14.855 −1.019 1.00 15.74 A C ATOM 3599 CD GLN A 230 70.996 −15.064 0.026 1.00 15.63 A C ATOM 3600 OE1 GLN A 230 71.920 −14.261 0.147 1.00 17.47 A O ATOM 3601 NE2 GLN A 230 70.879 −16.145 0.791 1.00 14.80 A N ATOM 3604 C GLN A 230 69.372 −14.143 −3.929 1.00 15.64 A C ATOM 3605 O GLN A 230 68.772 −13.147 −3.532 1.00 15.71 A O ATOM 3607 N SER A 231 70.305 −14.091 −4.878 1.00 15.55 A N ATOM 3608 CA SER A 231 70.678 −12.819 −5.504 1.00 15.35 A C ATOM 3610 CB SER A 231 71.927 −12.962 −6.385 1.00 15.10 A C ATOM 3613 OG SER A 231 71.603 −13.433 −7.681 1.00 15.04 A O ATOM 3615 C SER A 231 69.511 −12.251 −6.308 1.00 15.24 A C ATOM 3616 O SER A 231 69.441 −11.041 −6.525 1.00 15.43 A O ATOM 3618 N VAL A 232 68.605 −13.126 −6.747 1.00 15.03 A N ATOM 3619 CA VAL A 232 67.343 −12.692 −7.341 1.00 15.37 A C ATOM 3621 CB VAL A 232 66.631 −13.837 −8.091 1.00 15.43 A C ATOM 3623 CG1 VAL A 232 65.234 −13.406 −8.544 1.00 14.95 A C ATOM 3627 CG2 VAL A 232 67.468 −14.282 −9.277 1.00 15.59 A C ATOM 3631 C VAL A 232 66.427 −12.130 −6.256 1.00 15.65 A C ATOM 3632 O VAL A 232 65.897 −11.027 −6.401 1.00 15.40 A O ATOM 3634 N TYR A 233 66.259 −12.882 −5.168 1.00 16.13 A N ATOM 3635 CA TYR A 233 65.453 −12.426 −4.030 1.00 16.89 A C ATOM 3637 CB TYR A 233 65.588 −13.370 −2.825 1.00 16.70 A C ATOM 3640 CG TYR A 233 65.023 −14.766 −2.995 1.00 16.10 A C ATOM 3641 CD1 TYR A 233 64.102 −15.068 −4.001 1.00 17.42 A C ATOM 3643 CE1 TYR A 233 63.584 −16.348 −4.137 1.00 16.75 A C ATOM 3645 CZ TYR A 233 63.969 −17.336 −3.253 1.00 16.03 A C ATOM 3646 OH TYR A 233 63.452 −18.601 −3.388 1.00 17.62 A O ATOM 3648 CE2 TYR A 233 64.868 −17.060 −2.241 1.00 14.85 A C ATOM 3650 CD2 TYR A 233 65.385 −15.782 −2.115 1.00 14.89 A C ATOM 3652 C TYR A 233 65.841 −11.016 −3.591 1.00 17.81 A C ATOM 3653 O TYR A 233 64.977 −10.199 −3.267 1.00 17.90 A O ATOM 3655 N GLN A 234 67.142 −10.743 −3.577 1.00 19.03 A N ATOM 3656 CA GLN A 234 67.656 −9.424 −3.212 1.00 20.11 A C ATOM 3658 CB GLN A 234 69.178 −9.474 −3.026 1.00 20.14 A C ATOM 3661 CG GLN A 234 69.614 −10.305 −1.821 1.00 20.32 A C ATOM 3664 CD GLN A 234 71.113 −10.522 −1.755 1.00 20.42 A C ATOM 3665 OE1 GLN A 234 71.897 −9.618 −2.046 1.00 21.90 A O ATOM 3666 NE2 GLN A 234 71.519 −11.725 −1.359 1.00 19.04 A N ATOM 3669 C GLN A 234 67.273 −8.370 −4.251 1.00 20.93 A C ATOM 3670 O GLN A 234 66.878 −7.258 −3.890 1.00 20.70 A O ATOM 3672 N ARG A 235 67.380 −8.728 −5.533 1.00 21.91 A N ATOM 3673 CA ARG A 235 66.999 −7.828 −6.629 1.00 22.67 A C ATOM 3675 CB ARG A 235 67.476 −8.369 −7.989 1.00 23.14 A C ATOM 3678 CG ARG A 235 67.224 −7.413 −9.167 1.00 24.55 A C ATOM 3681 CD ARG A 235 68.367 −7.390 −10.199 1.00 27.72 A C ATOM 3684 NE ARG A 235 68.169 −8.321 −11.317 1.00 30.54 A N ATOM 3686 CZ ARG A 235 68.777 −9.502 −11.474 1.00 31.20 A C ATOM 3687 NH1 ARG A 235 69.652 −9.961 −10.582 1.00 31.84 A N ATOM 3690 NH2 ARG A 235 68.502 −10.239 −12.547 1.00 30.15 A N ATOM 3693 C ARG A 235 65.489 −7.586 −6.647 1.00 22.58 A C ATOM 3694 O ARG A 235 65.041 −6.485 −6.977 1.00 22.79 A O ATOM 3696 N ASP A 236 64.714 −8.613 −6.298 1.00 22.21 A N ATOM 3697 CA ASP A 236 63.264 −8.470 −6.137 1.00 22.10 A C ATOM 3699 CB ASP A 236 62.602 −9.827 −5.858 1.00 21.87 A C ATOM 3702 CG ASP A 236 62.525 −10.721 −7.087 1.00 21.53 A C ATOM 3703 OD1 ASP A 236 62.684 −10.224 −8.222 1.00 19.56 A O ATOM 3704 OD2 ASP A 236 62.293 −11.936 −6.907 1.00 20.26 A O ATOM 3705 C ASP A 236 62.926 −7.513 −4.995 1.00 22.23 A C ATOM 3706 O ASP A 236 61.997 −6.712 −5.107 1.00 22.26 A O ATOM 3708 N LEU A 237 63.686 −7.598 −3.902 1.00 22.39 A N ATOM 3709 CA LEU A 237 63.391 −6.829 −2.693 1.00 22.41 A C ATOM 3711 CB LEU A 237 64.157 −7.387 −1.489 1.00 22.11 A C ATOM 3714 CG LEU A 237 63.678 −6.902 −0.118 1.00 21.18 A C ATOM 3716 CD1 LEU A 237 62.211 −7.251 0.103 1.00 20.99 A C ATOM 3720 CD2 LEU A 237 64.532 −7.497 0.986 1.00 20.81 A C ATOM 3724 C LEU A 237 63.701 −5.347 −2.860 1.00 22.97 A C ATOM 3725 O LEU A 237 62.888 −4.503 −2.487 1.00 23.24 A O ATOM 3727 N ARG A 238 64.870 −5.032 −3.414 1.00 23.56 A N ATOM 3728 CA ARG A 238 65.252 −3.637 −3.655 1.00 23.85 A C ATOM 3730 CB ARG A 238 66.594 −3.544 −4.391 1.00 23.60 A C ATOM 3733 CG ARG A 238 67.798 −3.930 −3.546 1.00 23.92 A C ATOM 3736 CD ARG A 238 69.109 −3.464 −4.176 1.00 25.61 A C ATOM 3739 NE ARG A 238 69.289 −3.951 −5.547 1.00 26.87 A N ATOM 3741 CZ ARG A 238 69.725 −5.168 −5.887 1.00 27.26 A C ATOM 3742 NH1 ARG A 238 70.036 −6.073 −4.961 1.00 27.13 A N ATOM 3745 NH2 ARG A 238 69.847 −5.487 −7.172 1.00 26.94 A N ATOM 3748 C ARG A 238 64.169 −2.900 −4.446 1.00 24.35 A C ATOM 3749 O ARG A 238 63.854 −1.750 −4.142 1.00 24.59 A O ATOM 3751 N GLU A 239 63.600 −3.575 −5.445 1.00 24.73 A N ATOM 3752 CA GLU A 239 62.514 −3.020 −6.259 1.00 25.20 A C ATOM 3754 CB GLU A 239 62.197 −3.957 −7.431 1.00 25.81 A C ATOM 3757 CG GLU A 239 61.161 −3.414 −8.425 1.00 28.50 A C ATOM 3760 CD GLU A 239 60.814 −4.406 −9.530 1.00 31.93 A C ATOM 3761 OE1 GLU A 239 61.344 −5.542 −9.512 1.00 33.54 A O ATOM 3762 OE2 GLU A 239 60.005 −4.048 −10.417 1.00 33.16 A O ATOM 3763 C GLU A 239 61.254 −2.791 −5.423 1.00 24.67 A C ATOM 3764 O GLU A 239 60.556 −1.788 −5.596 1.00 24.49 A O ATOM 3766 N THR A 240 60.966 −3.730 −4.528 1.00 24.08 A N ATOM 3767 CA THR A 240 59.829 −3.610 −3.624 1.00 23.83 A C ATOM 3769 CB THR A 240 59.535 −4.946 −2.915 1.00 23.90 A C ATOM 3771 OG1 THR A 240 59.679 −6.026 −3.845 1.00 24.05 A O ATOM 3773 CG2 THR A 240 58.121 −4.953 −2.344 1.00 24.20 A C ATOM 3777 C THR A 240 60.089 −2.524 −2.578 1.00 23.67 A C ATOM 3778 O THR A 240 59.225 −1.686 −2.318 1.00 23.85 A O ATOM 3780 N SER A 241 61.284 −2.541 −1.990 1.00 23.37 A N ATOM 3781 CA SER A 241 61.684 −1.535 −1.003 1.00 23.30 A C ATOM 3783 CB SER A 241 63.097 −1.811 −0.495 1.00 23.25 A C ATOM 3786 OG SER A 241 63.136 −3.010 0.253 1.00 24.21 A O ATOM 3788 C SER A 241 61.612 −0.117 −1.561 1.00 23.34 A C ATOM 3789 O SER A 241 61.297 0.820 −0.831 1.00 23.53 A O ATOM 3791 N ARG A 242 61.912 0.040 −2.847 1.00 23.51 A N ATOM 3792 CA ARG A 242 61.754 1.334 −3.509 1.00 23.66 A C ATOM 3794 CB ARG A 242 62.312 1.304 −4.941 1.00 23.94 A C ATOM 3797 CG ARG A 242 63.841 1.370 −5.019 1.00 24.87 A C ATOM 3800 CD ARG A 242 64.335 1.973 −6.333 1.00 26.38 A C ATOM 3803 NE ARG A 242 64.074 1.116 −7.492 1.00 28.02 A N ATOM 3805 CZ ARG A 242 64.802 0.054 −7.848 1.00 27.68 A C ATOM 3806 NH1 ARG A 242 64.462 −0.643 −8.928 1.00 26.86 A N ATOM 3809 NH2 ARG A 242 65.861 −0.324 −7.135 1.00 27.49 A N ATOM 3812 C ARG A 242 60.286 1.757 −3.514 1.00 23.31 A C ATOM 3813 O ARG A 242 59.976 2.920 −3.264 1.00 23.30 A O ATOM 3815 N TRP A 243 59.393 0.809 −3.788 1.00 23.18 A N ATOM 3816 CA TRP A 243 57.949 1.072 −3.768 1.00 23.23 A C ATOM 3818 CB TRP A 243 57.177 −0.111 −4.369 1.00 23.16 A C ATOM 3821 CG TRP A 243 55.704 −0.106 −4.072 1.00 23.21 A C ATOM 3822 CD1 TRP A 243 54.729 0.555 −4.762 1.00 23.71 A C ATOM 3824 NE1 TRP A 243 53.499 0.317 −4.193 1.00 23.58 A N ATOM 3826 CE2 TRP A 243 53.662 −0.514 −3.116 1.00 23.23 A C ATOM 3827 CD2 TRP A 243 55.041 −0.802 −3.009 1.00 23.80 A C ATOM 3828 CE3 TRP A 243 55.478 −1.639 −1.973 1.00 23.02 A C ATOM 3830 CZ3 TRP A 243 54.535 −2.156 −1.091 1.00 22.08 A C ATOM 3832 CH2 TRP A 243 53.171 −1.849 −1.224 1.00 21.07 A C ATOM 3834 CZ2 TRP A 243 52.717 −1.033 −2.228 1.00 22.30 A C ATOM 3836 C TRP A 243 57.440 1.364 −2.353 1.00 23.29 A C ATOM 3837 O TRP A 243 56.706 2.332 −2.139 1.00 23.34 A O ATOM 3839 N TRP A 244 57.830 0.522 −1.399 1.00 23.09 A N ATOM 3840 CA TRP A 244 57.355 0.641 −0.019 1.00 22.81 A C ATOM 3842 CB TRP A 244 57.907 −0.507 0.834 1.00 22.28 A C ATOM 3845 CG TRP A 244 57.373 −0.551 2.242 1.00 21.81 A C ATOM 3846 CD1 TRP A 244 58.102 −0.486 3.393 1.00 22.74 A C ATOM 3848 NE1 TRP A 244 57.271 −0.556 4.486 1.00 22.22 A N ATOM 3850 CE2 TRP A 244 55.976 −0.667 4.055 1.00 21.12 A C ATOM 3851 CD2 TRP A 244 56.000 −0.666 2.645 1.00 20.57 A C ATOM 3852 CE3 TRP A 244 54.789 −0.766 1.951 1.00 19.76 A C ATOM 3854 CZ3 TRP A 244 53.610 −0.863 2.675 1.00 19.15 A C ATOM 3856 CH2 TRP A 244 53.619 −0.863 4.076 1.00 20.39 A C ATOM 3858 CZ2 TRP A 244 54.789 −0.764 4.784 1.00 21.06 A C ATOM 3860 C TRP A 244 57.699 1.996 0.608 1.00 23.07 A C ATOM 3861 O TRP A 244 56.851 2.609 1.256 1.00 23.27 A O ATOM 3863 N ARG A 245 58.930 2.467 0.408 1.00 23.23 A N ATOM 3864 CA ARG A 245 59.342 3.773 0.934 1.00 23.46 A C ATOM 3866 CB ARG A 245 60.839 4.028 0.708 1.00 23.77 A C ATOM 3869 CG ARG A 245 61.769 3.206 1.596 1.00 25.08 A C ATOM 3872 CD ARG A 245 63.090 3.929 1.866 1.00 28.31 A C ATOM 3875 NE ARG A 245 63.649 4.582 0.677 1.00 30.86 A N ATOM 3877 CZ ARG A 245 64.296 3.963 −0.312 1.00 32.93 A C ATOM 3878 NH1 ARG A 245 64.480 2.644 −0.296 1.00 33.65 A N ATOM 3881 NH2 ARG A 245 64.760 4.671 −1.338 1.00 33.03 A N ATOM 3884 C ARG A 245 58.532 4.898 0.295 1.00 23.19 A C ATOM 3885 O ARG A 245 58.020 5.776 0.994 1.00 23.26 A O ATOM 3887 N ARG A 246 58.426 4.860 −1.032 1.00 22.85 A N ATOM 3888 CA ARG A 246 57.653 5.843 −1.799 1.00 22.73 A C ATOM 3890 CB ARG A 246 57.613 5.451 −3.282 1.00 23.21 A C ATOM 3893 CG ARG A 246 58.727 6.068 −4.126 1.00 26.50 A C ATOM 3896 CD ARG A 246 58.216 7.252 −4.944 1.00 30.69 A C ATOM 3899 NE ARG A 246 57.435 6.800 −6.098 1.00 33.43 A N ATOM 3901 CZ ARG A 246 57.944 6.440 −7.278 1.00 35.34 A C ATOM 3902 NH1 ARG A 246 59.257 6.479 −7.505 1.00 35.77 A N ATOM 3905 NH2 ARG A 246 57.129 6.038 −8.249 1.00 35.70 A N ATOM 3908 C ARG A 246 56.232 5.997 −1.266 1.00 21.79 A C ATOM 3909 O ARG A 246 55.743 7.114 −1.101 1.00 21.69 A O ATOM 3911 N VAL A 247 55.579 4.870 −1.000 1.00 20.96 A N ATOM 3912 CA VAL A 247 54.252 4.871 −0.393 1.00 20.37 A C ATOM 3914 CB VAL A 247 53.725 3.434 −0.202 1.00 19.99 A C ATOM 3916 CG1 VAL A 247 53.571 2.751 −1.549 1.00 19.77 A C ATOM 3920 CG2 VAL A 247 52.400 3.433 0.549 1.00 19.80 A C ATOM 3924 C VAL A 247 54.293 5.600 0.955 1.00 20.50 A C ATOM 3925 O VAL A 247 53.458 6.463 1.227 1.00 19.95 A O ATOM 3927 N GLY A 248 55.275 5.247 1.783 1.00 20.89 A N ATOM 3928 CA GLY A 248 55.515 5.921 3.059 1.00 21.19 A C ATOM 3931 C GLY A 248 54.386 5.801 4.067 1.00 21.62 A C ATOM 3932 O GLY A 248 54.129 6.736 4.827 1.00 21.37 A O ATOM 3934 N LEU A 249 53.726 4.645 4.090 1.00 22.43 A N ATOM 3935 CA LEU A 249 52.558 4.438 4.952 1.00 23.00 A C ATOM 3937 CB LEU A 249 51.685 3.290 4.421 1.00 22.92 A C ATOM 3940 CG LEU A 249 50.171 3.488 4.554 1.00 22.33 A C ATOM 3942 CD1 LEU A 249 49.692 4.615 3.649 1.00 21.36 A C ATOM 3946 CD2 LEU A 249 49.430 2.205 4.229 1.00 21.54 A C ATOM 3950 C LEU A 249 52.978 4.172 6.403 1.00 23.55 A C ATOM 3951 O LEU A 249 52.390 4.726 7.336 1.00 23.31 A O ATOM 3953 N ALA A 250 53.996 3.332 6.584 1.00 24.09 A N ATOM 3954 CA ALA A 250 54.538 3.034 7.913 1.00 24.42 A C ATOM 3956 CB ALA A 250 55.713 2.072 7.798 1.00 24.82 A C ATOM 3960 C ALA A 250 54.965 4.302 8.658 1.00 24.51 A C ATOM 3961 O ALA A 250 54.703 4.439 9.855 1.00 24.78 A O ATOM 3963 N THR A 251 55.620 5.218 7.944 1.00 24.26 A N ATOM 3964 CA THR A 251 56.070 6.486 8.520 1.00 23.84 A C ATOM 3966 CB THR A 251 56.889 7.311 7.504 1.00 23.73 A C ATOM 3968 OG1 THR A 251 57.988 6.530 7.022 1.00 23.21 A O ATOM 3970 CG2 THR A 251 57.413 8.596 8.146 1.00 23.03 A C ATOM 3974 C THR A 251 54.904 7.354 8.990 1.00 23.80 A C ATOM 3975 O THR A 251 54.852 7.748 10.154 1.00 24.05 A O ATOM 3977 N LYS A 252 53.973 7.638 8.082 1.00 23.59 A N ATOM 3978 CA LYS A 252 52.912 8.617 8.339 1.00 23.66 A C ATOM 3980 CB LYS A 252 52.238 9.041 7.025 1.00 23.72 A C ATOM 3983 CG LYS A 252 53.191 9.682 5.999 1.00 24.88 A C ATOM 3986 CD LYS A 252 53.744 11.038 6.465 1.00 25.58 A C ATOM 3989 CE LYS A 252 55.000 11.436 5.698 1.00 25.21 A C ATOM 3992 NZ LYS A 252 55.739 12.535 6.380 1.00 24.66 A N ATOM 3996 C LYS A 252 51.872 8.114 9.343 1.00 23.54 A C ATOM 3997 O LYS A 252 51.453 8.856 10.234 1.00 23.17 A O ATOM 3999 N LEU A 253 51.461 6.858 9.200 1.00 23.95 A N ATOM 4000 CA LEU A 253 50.579 6.226 10.181 1.00 24.13 A C ATOM 4002 CB LEU A 253 49.901 4.980 9.596 1.00 23.73 A C ATOM 4005 CG LEU A 253 48.663 5.213 8.724 1.00 22.61 A C ATOM 4007 CD1 LEU A 253 48.839 6.393 7.784 1.00 22.35 A C ATOM 4011 CD2 LEU A 253 48.328 3.954 7.943 1.00 23.69 A C ATOM 4015 C LEU A 253 51.404 5.863 11.414 1.00 24.78 A C ATOM 4016 O LEU A 253 52.176 4.901 11.389 1.00 25.30 A O ATOM 4018 N HIS A 254 51.238 6.638 12.486 1.00 24.95 A N ATOM 4019 CA HIS A 254 52.075 6.499 13.685 1.00 25.19 A C ATOM 4021 CB HIS A 254 51.757 7.594 14.714 1.00 25.53 A C ATOM 4024 CG HIS A 254 51.801 8.987 14.160 1.00 26.66 A C ATOM 4025 ND1 HIS A 254 52.813 9.434 13.337 1.00 26.59 A N ATOM 4027 CE1 HIS A 254 52.587 10.693 13.008 1.00 27.01 A C ATOM 4029 NE2 HIS A 254 51.468 11.082 13.593 1.00 27.77 A N ATOM 4031 CD2 HIS A 254 50.958 10.036 14.322 1.00 27.37 A C ATOM 4033 C HIS A 254 51.926 5.125 14.341 1.00 25.07 A C ATOM 4034 O HIS A 254 52.909 4.535 14.788 1.00 25.17 A O ATOM 4036 N PHE A 255 50.694 4.627 14.391 1.00 25.01 A N ATOM 4037 CA PHE A 255 50.392 3.332 15.013 1.00 25.06 A C ATOM 4039 CB PHE A 255 48.870 3.157 15.153 1.00 24.83 A C ATOM 4042 CG PHE A 255 48.151 2.999 13.837 1.00 24.67 A C ATOM 4043 CD1 PHE A 255 48.013 1.745 13.248 1.00 25.14 A C ATOM 4045 CE1 PHE A 255 47.361 1.596 12.027 1.00 24.77 A C ATOM 4047 CZ PHE A 255 46.838 2.708 11.386 1.00 25.06 A C ATOM 4049 CE2 PHE A 255 46.970 3.965 11.963 1.00 25.14 A C ATOM 4051 CD2 PHE A 255 47.624 4.105 13.182 1.00 24.68 A C ATOM 4053 C PHE A 255 50.962 2.125 14.256 1.00 25.30 A C ATOM 4054 O PHE A 255 51.288 1.106 14.869 1.00 25.15 A O ATOM 4056 N ALA A 256 51.078 2.245 12.934 1.00 25.66 A N ATOM 4057 CA ALA A 256 51.252 1.084 12.055 1.00 25.87 A C ATOM 4059 CB ALA A 256 50.884 1.454 10.622 1.00 25.83 A C ATOM 4063 C ALA A 256 52.651 0.468 12.095 1.00 26.20 A C ATOM 4064 O ALA A 256 53.654 1.177 12.226 1.00 26.11 A O ATOM 4066 N ARG A 257 52.696 −0.857 11.962 1.00 26.63 A N ATOM 4067 CA ARG A 257 53.943 −1.621 12.006 1.00 27.23 A C ATOM 4069 CB ARG A 257 53.705 −2.990 12.643 1.00 27.59 A C ATOM 4072 CG ARG A 257 53.164 −2.956 14.070 1.00 29.15 A C ATOM 4075 CD ARG A 257 52.777 −4.360 14.518 1.00 30.54 A C ATOM 4078 NE ARG A 257 51.707 −4.906 13.678 1.00 31.05 A N ATOM 4080 CZ ARG A 257 51.478 −6.201 13.463 1.00 31.20 A C ATOM 4081 NH1 ARG A 257 52.242 −7.139 14.018 1.00 31.74 A N ATOM 4084 NH2 ARG A 257 50.471 −6.563 12.674 1.00 31.30 A N ATOM 4087 C ARG A 257 54.516 −1.828 10.608 1.00 27.05 A C ATOM 4088 O ARG A 257 53.771 −2.041 9.651 1.00 27.10 A O ATOM 4090 N ASP A 258 55.844 −1.788 10.508 1.00 26.97 A N ATOM 4091 CA ASP A 258 56.548 −1.937 9.236 1.00 26.68 A C ATOM 4093 CB ASP A 258 57.713 −0.945 9.169 1.00 26.49 A C ATOM 4096 CG ASP A 258 58.241 −0.759 7.764 1.00 26.72 A C ATOM 4097 OD1 ASP A 258 58.470 −1.768 7.065 1.00 26.55 A O ATOM 4098 OD2 ASP A 258 58.428 0.405 7.351 1.00 28.47 A O ATOM 4099 C ASP A 258 57.049 −3.373 9.073 1.00 26.57 A C ATOM 4100 O ASP A 258 58.058 −3.759 9.667 1.00 26.72 A O ATOM 4102 N ARG A 259 56.342 −4.157 8.262 1.00 26.49 A N ATOM 4103 CA ARG A 259 56.655 −5.575 8.073 1.00 26.58 A C ATOM 4105 CB ARG A 259 55.578 −6.447 8.738 1.00 27.25 A C ATOM 4108 CG ARG A 259 55.479 −6.323 10.260 1.00 28.80 A C ATOM 4111 CD ARG A 259 56.423 −7.277 10.983 1.00 30.14 A C ATOM 4114 NE ARG A 259 56.188 −7.278 12.428 1.00 32.18 A N ATOM 4116 CZ ARG A 259 56.604 −6.335 13.275 1.00 32.94 A C ATOM 4117 NH1 ARG A 259 57.290 −5.280 12.842 1.00 34.19 A N ATOM 4120 NH2 ARG A 259 56.329 −6.444 14.572 1.00 32.41 A N ATOM 4123 C ARG A 259 56.758 −5.934 6.588 1.00 25.53 A C ATOM 4124 O ARG A 259 55.939 −6.696 6.070 1.00 25.27 A O ATOM 4126 N LEU A 260 57.759 −5.383 5.905 1.00 24.36 A N ATOM 4127 CA LEU A 260 57.987 −5.709 4.496 1.00 23.56 A C ATOM 4129 CB LEU A 260 58.444 −4.482 3.705 1.00 23.49 A C ATOM 4132 CG LEU A 260 58.738 −4.732 2.220 1.00 22.82 A C ATOM 4134 CD1 LEU A 260 57.541 −5.359 1.522 1.00 22.27 A C ATOM 4138 CD2 LEU A 260 59.145 −3.448 1.530 1.00 23.21 A C ATOM 4142 C LEU A 260 59.024 −6.812 4.382 1.00 22.93 A C ATOM 4143 O LEU A 260 58.782 −7.834 3.736 1.00 23.24 A O ATOM 4145 N ILE A 261 60.175 −6.592 5.013 1.00 22.02 A N ATOM 4146 CA ILE A 261 61.239 −7.595 5.083 1.00 21.34 A C ATOM 4148 CB ILE A 261 62.309 −7.215 6.131 1.00 21.16 A C ATOM 4150 CG1 ILE A 261 63.001 −5.893 5.765 1.00 20.68 A C ATOM 4153 CD1 ILE A 261 63.318 −5.016 6.972 1.00 19.12 A C ATOM 4157 CG2 ILE A 261 63.336 −8.335 6.266 1.00 20.90 A C ATOM 4161 C ILE A 261 60.644 −8.943 5.477 1.00 21.18 A C ATOM 4162 O ILE A 261 60.982 −9.973 4.900 1.00 20.99 A O ATOM 4164 N GLU A 262 59.747 −8.915 6.459 1.00 21.36 A N ATOM 4165 CA GLU A 262 59.060 −10.112 6.927 1.00 21.68 A C ATOM 4167 CB GLU A 262 58.375 −9.849 8.276 1.00 21.72 A C ATOM 4170 CG GLU A 262 59.332 −9.744 9.477 1.00 21.84 A C ATOM 4173 CD GLU A 262 59.863 −8.335 9.740 1.00 21.66 A C ATOM 4174 OE1 GLU A 262 59.610 −7.413 8.933 1.00 21.94 A O ATOM 4175 OE2 GLU A 262 60.540 −8.150 10.772 1.00 21.41 A O ATOM 4176 C GLU A 262 58.036 −10.625 5.911 1.00 22.32 A C ATOM 4177 O GLU A 262 57.901 −11.837 5.728 1.00 23.24 A O ATOM 4179 N SER A 263 57.313 −9.712 5.262 1.00 22.49 A N ATOM 4180 CA SER A 263 56.288 −10.094 4.277 1.00 22.31 A C ATOM 4182 CB SER A 263 55.386 −8.909 3.919 1.00 22.29 A C ATOM 4185 OG SER A 263 54.431 −8.678 4.939 1.00 22.39 A O ATOM 4187 C SER A 263 56.883 −10.687 3.004 1.00 22.14 A C ATOM 4188 O SER A 263 56.274 −11.555 2.382 1.00 22.58 A O ATOM 4190 N PHE A 264 58.059 −10.214 2.606 1.00 22.01 A N ATOM 4191 CA PHE A 264 58.750 −10.795 1.460 1.00 22.14 A C ATOM 4193 CB PHE A 264 59.942 −9.933 1.038 1.00 22.16 A C ATOM 4196 CG PHE A 264 60.511 −10.311 −0.297 1.00 21.05 A C ATOM 4197 CD1 PHE A 264 59.905 −9.880 −1.467 1.00 20.84 A C ATOM 4199 CE1 PHE A 264 60.418 −10.230 −2.703 1.00 21.07 A C ATOM 4201 CZ PHE A 264 61.552 −11.021 −2.778 1.00 22.11 A C ATOM 4203 CE2 PHE A 264 62.164 −11.460 −1.615 1.00 21.87 A C ATOM 4205 CD2 PHE A 264 61.641 −11.108 −0.384 1.00 20.79 A C ATOM 4207 C PHE A 264 59.212 −12.211 1.800 1.00 22.40 A C ATOM 4208 O PHE A 264 58.950 −13.149 1.042 1.00 22.39 A O ATOM 4210 N TYR A 265 59.885 −12.349 2.946 1.00 22.32 A N ATOM 4211 CA TYR A 265 60.319 −13.651 3.472 1.00 22.09 A C ATOM 4213 CB TYR A 265 60.930 −13.489 4.872 1.00 22.28 A C ATOM 4216 CG TYR A 265 61.069 −14.783 5.649 1.00 25.25 A C ATOM 4217 CD1 TYR A 265 62.150 −15.636 5.438 1.00 27.20 A C ATOM 4219 CE1 TYR A 265 62.281 −16.826 6.149 1.00 27.66 A C ATOM 4221 CZ TYR A 265 61.322 −17.173 7.084 1.00 29.34 A C ATOM 4222 OH TYR A 265 61.447 −18.349 7.791 1.00 32.52 A O ATOM 4224 CE2 TYR A 265 60.238 −16.344 7.314 1.00 29.12 A C ATOM 4226 CD2 TYR A 265 60.117 −15.156 6.598 1.00 28.54 A C ATOM 4228 C TYR A 265 59.163 −14.649 3.513 1.00 21.42 A C ATOM 4229 O TYR A 265 59.334 −15.821 3.175 1.00 21.62 A O ATOM 4231 N TRP A 266 57.992 −14.180 3.935 1.00 20.65 A N ATOM 4232 CA TRP A 266 56.774 −14.980 3.860 1.00 20.27 A C ATOM 4234 CB TRP A 266 55.576 −14.189 4.407 1.00 20.42 A C ATOM 4237 CG TRP A 266 54.261 −14.891 4.247 1.00 19.95 A C ATOM 4238 CD1 TRP A 266 53.460 −14.889 3.143 1.00 19.27 A C ATOM 4240 NE1 TRP A 266 52.339 −15.648 3.368 1.00 19.44 A N ATOM 4242 CE2 TRP A 266 52.394 −16.154 4.639 1.00 19.32 A C ATOM 4243 CD2 TRP A 266 53.595 −15.697 5.223 1.00 19.63 A C ATOM 4244 CE3 TRP A 266 53.895 −16.075 6.537 1.00 20.02 A C ATOM 4246 CZ3 TRP A 266 53.000 −16.890 7.215 1.00 20.91 A C ATOM 4248 CH2 TRP A 266 51.812 −17.331 6.604 1.00 19.64 A C ATOM 4250 CZ2 TRP A 266 51.493 −16.975 5.321 1.00 18.62 A C ATOM 4252 C TRP A 266 56.509 −15.411 2.416 1.00 19.60 A C ATOM 4253 O TRP A 266 56.278 −16.590 2.146 1.00 19.63 A O ATOM 4255 N ALA A 267 56.556 −14.446 1.498 1.00 18.71 A N ATOM 4256 CA ALA A 267 56.272 −14.687 0.081 1.00 18.06 A C ATOM 4258 CB ALA A 267 56.264 −13.372 −0.682 1.00 18.02 A C ATOM 4262 C ALA A 267 57.241 −15.669 −0.581 1.00 17.64 A C ATOM 4263 O ALA A 267 56.872 −16.341 −1.542 1.00 17.61 A O ATOM 4265 N VAL A 268 58.470 −15.748 −0.069 1.00 17.18 A N ATOM 4266 CA VAL A 268 59.479 −16.690 −0.579 1.00 16.54 A C ATOM 4268 CB VAL A 268 60.872 −16.405 0.039 1.00 16.49 A C ATOM 4270 CG1 VAL A 268 61.390 −15.062 −0.451 1.00 16.73 A C ATOM 4274 CG2 VAL A 268 61.866 −17.511 −0.297 1.00 16.29 A C ATOM 4278 C VAL A 268 59.080 −18.154 −0.340 1.00 15.77 A C ATOM 4279 O VAL A 268 59.385 −19.028 −1.150 1.00 15.33 A O ATOM 4281 N GLY A 269 58.395 −18.415 0.766 1.00 15.52 A N ATOM 4282 CA GLY A 269 57.832 −19.737 1.016 1.00 15.52 A C ATOM 4285 C GLY A 269 56.673 −20.066 0.090 1.00 15.20 A C ATOM 4286 O GLY A 269 56.391 −21.237 −0.160 1.00 14.64 A O ATOM 4288 N VAL A 270 56.007 −19.032 −0.419 1.00 14.97 A N ATOM 4289 CA VAL A 270 54.835 −19.200 −1.280 1.00 14.94 A C ATOM 4291 CB VAL A 270 53.887 −17.979 −1.178 1.00 14.38 A C ATOM 4293 CG1 VAL A 270 52.554 −18.286 −1.826 1.00 13.66 A C ATOM 4297 CG2 VAL A 270 53.677 −17.584 0.272 1.00 12.55 A C ATOM 4301 C VAL A 270 55.230 −19.429 −2.747 1.00 15.75 A C ATOM 4302 O VAL A 270 54.475 −20.036 −3.508 1.00 16.17 A O ATOM 4304 N ALA A 271 56.410 −18.948 −3.140 1.00 16.28 A N ATOM 4305 CA ALA A 271 56.906 −19.120 −4.510 1.00 16.56 A C ATOM 4307 CB ALA A 271 56.190 −18.161 −5.450 1.00 16.49 A C ATOM 4311 C ALA A 271 58.429 −18.926 −4.586 1.00 16.90 A C ATOM 4312 O ALA A 271 58.925 −17.849 −4.925 1.00 16.39 A O ATOM 4314 N PHE A 272 59.155 −19.993 −4.273 1.00 17.53 A N ATOM 4315 CA PHE A 272 60.616 −19.960 −4.183 1.00 18.21 A C ATOM 4317 CB PHE A 272 61.119 −21.181 −3.416 1.00 18.52 A C ATOM 4320 CG PHE A 272 61.061 −22.460 −4.207 1.00 19.27 A C ATOM 4321 CD1 PHE A 272 62.180 −22.915 −4.894 1.00 19.23 A C ATOM 4323 CE1 PHE A 272 62.132 −24.095 −5.624 1.00 21.26 A C ATOM 4325 CZ PHE A 272 60.951 −24.832 −5.677 1.00 22.55 A C ATOM 4327 CE2 PHE A 272 59.825 −24.383 −4.999 1.00 21.20 A C ATOM 4329 CD2 PHE A 272 59.885 −23.204 −4.271 1.00 20.42 A C ATOM 4331 C PHE A 272 61.325 −19.925 −5.533 1.00 18.82 A C ATOM 4332 O PHE A 272 62.415 −19.362 −5.642 1.00 19.34 A O ATOM 4334 N GLU A 273 60.728 −20.554 −6.545 1.00 19.20 A N ATOM 4335 CA GLU A 273 61.364 −20.679 −7.859 1.00 19.20 A C ATOM 4337 CB GLU A 273 60.476 −21.457 −8.842 1.00 19.46 A C ATOM 4340 CG GLU A 273 60.093 −22.880 −8.399 1.00 20.71 A C ATOM 4343 CD GLU A 273 58.655 −23.005 −7.879 1.00 22.87 A C ATOM 4344 OE1 GLU A 273 58.171 −22.086 −7.178 1.00 22.37 A O ATOM 4345 OE2 GLU A 273 58.008 −24.035 −8.173 1.00 22.23 A O ATOM 4346 C GLU A 273 61.680 −19.288 −8.416 1.00 18.84 A C ATOM 4347 O GLU A 273 60.846 −18.388 −8.333 1.00 19.02 A O ATOM 4349 N PRO A 274 62.887 −19.108 −8.984 1.00 18.67 A N ATOM 4350 CA PRO A 274 63.353 −17.773 −9.375 1.00 18.87 A C ATOM 4352 CB PRO A 274 64.762 −18.034 −9.924 1.00 18.89 A C ATOM 4355 CG PRO A 274 64.786 −19.471 −10.280 1.00 18.67 A C ATOM 4358 CD PRO A 274 63.861 −20.157 −9.335 1.00 18.65 A C ATOM 4361 C PRO A 274 62.487 −17.066 −10.422 1.00 19.21 A C ATOM 4362 O PRO A 274 62.470 −15.837 −10.467 1.00 19.76 A O ATOM 4363 N GLN A 275 61.771 −17.829 −11.243 1.00 19.37 A N ATOM 4364 CA GLN A 275 60.924 −17.247 −12.286 1.00 19.69 A C ATOM 4366 CB GLN A 275 60.631 −18.272 −13.395 1.00 19.95 A C ATOM 4369 CG GLN A 275 59.739 −19.459 −12.995 1.00 20.88 A C ATOM 4372 CD GLN A 275 60.526 −20.705 −12.614 1.00 21.94 A C ATOM 4373 OE1 GLN A 275 61.655 −20.620 −12.130 1.00 24.29 A O ATOM 4374 NE2 GLN A 275 59.924 −21.870 −12.826 1.00 22.72 A N ATOM 4377 C GLN A 275 59.607 −16.633 −11.782 1.00 19.72 A C ATOM 4378 O GLN A 275 58.905 −15.991 −12.562 1.00 20.27 A O ATOM 4380 N TYR A 276 59.270 −16.819 −10.504 1.00 19.68 A N ATOM 4381 CA TYR A 276 58.020 −16.279 −9.942 1.00 19.96 A C ATOM 4383 CB TYR A 276 57.339 −17.321 −9.044 1.00 20.06 A C ATOM 4386 CG TYR A 276 56.799 −18.541 −9.762 1.00 21.44 A C ATOM 4387 CD1 TYR A 276 55.960 −18.417 −10.867 1.00 21.90 A C ATOM 4389 CE1 TYR A 276 55.455 −19.537 −11.516 1.00 22.01 A C ATOM 4391 CZ TYR A 276 55.773 −20.800 −11.051 1.00 23.26 A C ATOM 4392 OH TYR A 276 55.276 −21.917 −11.683 1.00 24.08 A O ATOM 4394 CE2 TYR A 276 56.592 −20.949 −9.946 1.00 23.34 A C ATOM 4396 CD2 TYR A 276 57.095 −19.824 −9.306 1.00 22.64 A C ATOM 4398 C TYR A 276 58.219 −14.977 −9.147 1.00 19.98 A C ATOM 4399 O TYR A 276 57.639 −14.802 −8.072 1.00 19.72 A O ATOM 4401 N SER A 277 59.021 −14.059 −9.682 1.00 20.07 A N ATOM 4402 CA SER A 277 59.270 −12.770 −9.027 1.00 19.67 A C ATOM 4404 CB SER A 277 60.267 −11.938 −9.838 1.00 19.60 A C ATOM 4407 OG SER A 277 61.513 −12.603 −9.956 1.00 20.14 A O ATOM 4409 C SER A 277 57.984 −11.973 −8.822 1.00 19.33 A C ATOM 4410 O SER A 277 57.776 −11.385 −7.761 1.00 19.21 A O ATOM 4412 N ASP A 278 57.123 −11.959 −9.835 1.00 19.20 A N ATOM 4413 CA ASP A 278 55.859 −11.226 −9.754 1.00 19.25 A C ATOM 4415 CB ASP A 278 55.085 −11.316 −11.077 1.00 19.35 A C ATOM 4418 CG ASP A 278 55.629 −10.380 −12.143 1.00 18.93 A C ATOM 4419 OD1 ASP A 278 56.348 −9.419 −11.796 1.00 18.90 A O ATOM 4420 OD2 ASP A 278 55.327 −10.600 −13.333 1.00 18.56 A O ATOM 4421 C ASP A 278 54.979 −11.716 −8.606 1.00 19.13 A C ATOM 4422 O ASP A 278 54.356 −10.908 −7.916 1.00 19.10 A O ATOM 4424 N CYS A 279 54.930 −13.031 −8.403 1.00 18.93 A N ATOM 4425 CA CYS A 279 54.146 −13.601 −7.307 1.00 18.82 A C ATOM 4427 CB CYS A 279 54.090 −15.129 −7.401 1.00 18.89 A C ATOM 4430 SG CYS A 279 52.896 −15.884 −6.264 1.00 18.55 A S ATOM 4432 C CYS A 279 54.716 −13.185 −5.956 1.00 18.54 A C ATOM 4433 O CYS A 279 53.965 −12.865 −5.033 1.00 18.37 A O ATOM 4435 N ARG A 280 56.044 −13.189 −5.853 1.00 18.40 A N ATOM 4436 CA ARG A 280 56.730 −12.759 −4.635 1.00 18.00 A C ATOM 4438 CB ARG A 280 58.239 −13.013 −4.735 1.00 18.28 A C ATOM 4441 CG ARG A 280 58.634 −14.477 −4.592 1.00 18.99 A C ATOM 4444 CD ARG A 280 60.137 −14.630 −4.420 1.00 19.95 A C ATOM 4447 NE ARG A 280 60.867 −14.212 −5.615 1.00 21.16 A N ATOM 4449 CZ ARG A 280 61.053 −14.964 −6.700 1.00 23.15 A C ATOM 4450 NH1 ARG A 280 60.562 −16.198 −6.772 1.00 24.11 A N ATOM 4453 NH2 ARG A 280 61.736 −14.475 −7.728 1.00 24.44 A N ATOM 4456 C ARG A 280 56.464 −11.285 −4.344 1.00 17.11 A C ATOM 4457 O ARG A 280 56.147 −10.923 −3.210 1.00 16.85 A O ATOM 4459 N ASN A 281 56.586 −10.443 −5.369 1.00 16.30 A N ATOM 4460 CA ASN A 281 56.313 −9.014 −5.220 1.00 15.91 A C ATOM 4462 CB ASN A 281 56.684 −8.244 −6.493 1.00 16.20 A C ATOM 4465 CG ASN A 281 58.192 −8.136 −6.703 1.00 17.16 A C ATOM 4466 OD1 ASN A 281 58.988 −8.551 −5.858 1.00 17.08 A O ATOM 4467 ND2 ASN A 281 58.588 −7.568 −7.839 1.00 18.22 A N ATOM 4470 C ASN A 281 54.857 −8.741 −4.841 1.00 15.14 A C ATOM 4471 O ASN A 281 54.595 −7.924 −3.964 1.00 15.32 A O ATOM 4473 N SER A 282 53.920 −9.432 −5.491 1.00 14.30 A N ATOM 4474 CA SER A 282 52.494 −9.294 −5.173 1.00 13.39 A C ATOM 4476 CB SER A 282 51.631 −10.127 −6.124 1.00 13.27 A C ATOM 4479 OG SER A 282 51.539 −9.524 −7.400 1.00 13.30 A O ATOM 4481 C SER A 282 52.202 −9.701 −3.731 1.00 12.98 A C ATOM 4482 O SER A 282 51.743 −8.880 −2.933 1.00 12.94 A O ATOM 4484 N VAL A 283 52.471 −10.963 −3.402 1.00 12.45 A N ATOM 4485 CA VAL A 283 52.241 −11.475 −2.050 1.00 12.34 A C ATOM 4487 CB VAL A 283 52.831 −12.895 −1.858 1.00 12.07 A C ATOM 4489 CG1 VAL A 283 52.867 −13.272 −0.387 1.00 11.16 A C ATOM 4493 CG2 VAL A 283 52.029 −13.918 −2.639 1.00 10.41 A C ATOM 4497 C VAL A 283 52.837 −10.520 −1.015 1.00 12.92 A C ATOM 4498 O VAL A 283 52.173 −10.150 −0.048 1.00 12.86 A O ATOM 4500 N ALA A 284 54.082 −10.111 −1.243 1.00 13.80 A N ATOM 4501 CA ALA A 284 54.772 −9.179 −0.351 1.00 14.74 A C ATOM 4503 CB ALA A 284 56.179 −8.900 −0.871 1.00 14.73 A C ATOM 4507 C ALA A 284 54.006 −7.864 −0.172 1.00 15.30 A C ATOM 4508 O ALA A 284 53.811 −7.400 0.952 1.00 14.93 A O ATOM 4510 N LYS A 285 53.578 −7.272 −1.283 1.00 16.13 A N ATOM 4511 CA LYS A 285 52.841 −6.012 −1.248 1.00 17.03 A C ATOM 4513 CB LYS A 285 52.562 −5.503 −2.668 1.00 17.14 A C ATOM 4516 CG LYS A 285 53.756 −4.834 −3.335 1.00 18.60 A C ATOM 4519 CD LYS A 285 53.407 −4.320 −4.722 1.00 21.08 A C ATOM 4522 CE LYS A 285 54.618 −3.718 −5.417 1.00 22.65 A C ATOM 4525 NZ LYS A 285 54.341 −3.399 −6.848 1.00 24.04 A N ATOM 4529 C LYS A 285 51.529 −6.160 −0.481 1.00 17.73 A C ATOM 4530 O LYS A 285 51.239 −5.379 0.431 1.00 17.94 A O ATOM 4532 N MET A 286 50.747 −7.171 −0.846 1.00 18.03 A N ATOM 4533 CA MET A 286 49.426 −7.367 −0.253 1.00 18.01 A C ATOM 4535 CB MET A 286 48.670 −8.498 −0.966 1.00 18.01 A C ATOM 4538 CG MET A 286 48.323 −8.209 −2.429 1.00 17.41 A C ATOM 4541 SD MET A 286 47.631 −6.560 −2.713 1.00 16.92 A S ATOM 4542 CE MET A 286 49.115 −5.597 −2.995 1.00 16.98 A C ATOM 4546 C MET A 286 49.524 −7.651 1.240 1.00 17.81 A C ATOM 4547 O MET A 286 48.835 −7.017 2.042 1.00 17.92 A O ATOM 4549 N PHE A 287 50.394 −8.587 1.606 1.00 17.47 A N ATOM 4550 CA PHE A 287 50.575 −8.976 3.007 1.00 17.44 A C ATOM 4552 CB PHE A 287 51.516 −10.186 3.094 1.00 17.98 A C ATOM 4555 CG PHE A 287 51.463 −10.925 4.409 1.00 20.17 A C ATOM 4556 CD1 PHE A 287 50.248 −11.252 5.004 1.00 22.99 A C ATOM 4558 CE1 PHE A 287 50.204 −11.947 6.205 1.00 23.48 A C ATOM 4560 CZ PHE A 287 51.380 −12.337 6.820 1.00 25.00 A C ATOM 4562 CE2 PHE A 287 52.598 −12.029 6.233 1.00 25.35 A C ATOM 4564 CD2 PHE A 287 52.634 −11.332 5.032 1.00 23.16 A C ATOM 4566 C PHE A 287 51.096 −7.818 3.871 1.00 16.40 A C ATOM 4567 O PHE A 287 50.848 −7.781 5.076 1.00 15.60 A O ATOM 4569 N SER A 288 51.809 −6.879 3.250 1.00 15.81 A N ATOM 4570 CA SER A 288 52.251 −5.667 3.934 1.00 15.38 A C ATOM 4572 CB SER A 288 53.333 −4.945 3.131 1.00 15.38 A C ATOM 4575 OG SER A 288 54.539 −5.688 3.137 1.00 15.78 A O ATOM 4577 C SER A 288 51.081 −4.728 4.202 1.00 15.29 A C ATOM 4578 O SER A 288 51.029 −4.099 5.256 1.00 15.32 A O ATOM 4580 N PHE A 289 50.149 −4.631 3.253 1.00 15.52 A N ATOM 4581 CA PHE A 289 48.899 −3.885 3.480 1.00 15.49 A C ATOM 4583 CB PHE A 289 48.121 −3.650 2.176 1.00 15.43 A C ATOM 4586 CG PHE A 289 48.484 −2.367 1.479 1.00 15.12 A C ATOM 4587 CD1 PHE A 289 48.164 −1.144 2.049 1.00 14.80 A C ATOM 4589 CE1 PHE A 289 48.499 0.040 1.420 1.00 16.15 A C ATOM 4591 CZ PHE A 289 49.159 0.011 0.206 1.00 17.05 A C ATOM 4593 CE2 PHE A 289 49.479 −1.204 −0.376 1.00 17.05 A C ATOM 4595 CD2 PHE A 289 49.144 −2.383 0.261 1.00 16.16 A C ATOM 4597 C PHE A 289 48.002 −4.582 4.503 1.00 15.27 A C ATOM 4598 O PHE A 289 47.393 −3.923 5.345 1.00 15.17 A O ATOM 4600 N VAL A 290 47.935 −5.910 4.431 1.00 15.14 A N ATOM 4601 CA VAL A 290 47.139 −6.696 5.373 1.00 15.03 A C ATOM 4603 CB VAL A 290 47.224 −8.201 5.068 1.00 14.64 A C ATOM 4605 CG1 VAL A 290 46.571 −9.010 6.175 1.00 14.66 A C ATOM 4609 CG2 VAL A 290 46.562 −8.497 3.739 1.00 14.94 A C ATOM 4613 C VAL A 290 47.551 −6.445 6.827 1.00 15.27 A C ATOM 4614 O VAL A 290 46.698 −6.185 7.673 1.00 15.36 A O ATOM 4616 N THR A 291 48.851 −6.503 7.110 1.00 15.61 A N ATOM 4617 CA THR A 291 49.340 −6.286 8.477 1.00 15.61 A C ATOM 4619 CB THR A 291 50.886 −6.410 8.595 1.00 15.42 A C ATOM 4621 OG1 THR A 291 51.520 −5.386 7.819 1.00 14.83 A O ATOM 4623 CG2 THR A 291 51.369 −7.784 8.132 1.00 14.64 A C ATOM 4627 C THR A 291 48.911 −4.916 9.001 1.00 15.68 A C ATOM 4628 O THR A 291 48.504 −4.791 10.157 1.00 16.01 A O ATOM 4630 N ILE A 292 48.991 −3.903 8.141 1.00 15.70 A N ATOM 4631 CA ILE A 292 48.639 −2.533 8.516 1.00 15.64 A C ATOM 4633 CB ILE A 292 49.192 −1.505 7.500 1.00 15.68 A C ATOM 4635 CG1 ILE A 292 50.722 −1.490 7.557 1.00 15.54 A C ATOM 4638 CD1 ILE A 292 51.357 −0.392 6.739 1.00 16.00 A C ATOM 4642 CG2 ILE A 292 48.639 −0.108 7.780 1.00 15.12 A C ATOM 4646 C ILE A 292 47.131 −2.359 8.661 1.00 15.48 A C ATOM 4647 O ILE A 292 46.669 −1.760 9.631 1.00 15.61 A O ATOM 4649 N ILE A 293 46.367 −2.885 7.708 1.00 15.26 A N ATOM 4650 CA ILE A 293 44.909 −2.805 7.779 1.00 15.32 A C ATOM 4652 CB ILE A 293 44.231 −3.333 6.495 1.00 15.16 A C ATOM 4654 CG1 ILE A 293 44.602 −2.472 5.282 1.00 15.39 A C ATOM 4657 CD1 ILE A 293 43.968 −1.107 5.275 1.00 15.43 A C ATOM 4661 CG2 ILE A 293 42.719 −3.348 6.658 1.00 15.54 A C ATOM 4665 C ILE A 293 44.394 −3.586 8.991 1.00 15.79 A C ATOM 4666 O ILE A 293 43.465 −3.144 9.664 1.00 15.61 A O ATOM 4668 N ASP A 294 45.012 −4.733 9.273 1.00 16.58 A N ATOM 4669 CA ASP A 294 44.653 −5.541 10.445 1.00 17.14 A C ATOM 4671 CB ASP A 294 45.511 −6.814 10.521 1.00 17.55 A C ATOM 4674 CG ASP A 294 45.018 −7.803 11.576 1.00 18.98 A C ATOM 4675 OD1 ASP A 294 43.790 −7.884 11.806 1.00 20.79 A O ATOM 4676 OD2 ASP A 294 45.861 −8.513 12.169 1.00 18.90 A O ATOM 4677 C ASP A 294 44.788 −4.741 11.743 1.00 16.97 A C ATOM 4678 O ASP A 294 43.999 −4.924 12.667 1.00 17.05 A O ATOM 4680 N ASP A 295 45.781 −3.857 11.808 1.00 16.76 A N ATOM 4681 CA ASP A 295 45.937 −2.965 12.958 1.00 16.73 A C ATOM 4683 CB ASP A 295 47.305 −2.268 12.940 1.00 16.88 A C ATOM 4686 CG ASP A 295 48.461 −3.220 13.210 1.00 17.30 A C ATOM 4687 OD1 ASP A 295 48.224 −4.372 13.634 1.00 17.28 A O ATOM 4688 OD2 ASP A 295 49.620 −2.806 12.998 1.00 18.54 A O ATOM 4689 C ASP A 295 44.825 −1.915 13.018 1.00 16.43 A C ATOM 4690 O ASP A 295 44.347 −1.589 14.105 1.00 16.59 A O ATOM 4692 N ILE A 296 44.420 −1.390 11.859 1.00 15.90 A N ATOM 4693 CA ILE A 296 43.353 −0.378 11.791 1.00 15.30 A C ATOM 4695 CB ILE A 296 43.100 0.114 10.346 1.00 14.79 A C ATOM 4697 CG1 ILE A 296 44.304 0.885 9.813 1.00 14.50 A C ATOM 4700 CD1 ILE A 296 44.210 1.200 8.336 1.00 13.16 A C ATOM 4704 CG2 ILE A 296 41.886 1.022 10.295 1.00 13.81 A C ATOM 4708 C ILE A 296 42.034 −0.917 12.345 1.00 15.43 A C ATOM 4709 O ILE A 296 41.305 −0.200 13.033 1.00 15.53 A O ATOM 4711 N TYR A 297 41.736 −2.178 12.040 1.00 15.29 A N ATOM 4712 CA TYR A 297 40.501 −2.820 12.495 1.00 15.11 A C ATOM 4714 CB TYR A 297 40.111 −3.966 11.553 1.00 15.56 A C ATOM 4717 CG TYR A 297 39.399 −3.528 10.288 1.00 16.05 A C ATOM 4718 CD1 TYR A 297 38.010 −3.476 10.235 1.00 15.95 A C ATOM 4720 CE1 TYR A 297 37.348 −3.086 9.081 1.00 15.39 A C ATOM 4722 CZ TYR A 297 38.074 −2.746 7.959 1.00 16.60 A C ATOM 4723 OH TYR A 297 37.414 −2.357 6.817 1.00 18.35 A O ATOM 4725 CE2 TYR A 297 39.456 −2.794 7.982 1.00 16.80 A C ATOM 4727 CD2 TYR A 297 40.110 −3.187 9.142 1.00 16.66 A C ATOM 4729 C TYR A 297 40.601 −3.343 13.928 1.00 14.50 A C ATOM 4730 O TYR A 297 39.645 −3.239 14.695 1.00 14.52 A O ATOM 4732 N ASP A 298 41.757 −3.901 14.280 1.00 14.10 A N ATOM 4733 CA ASP A 298 41.949 −4.561 15.575 1.00 13.63 A C ATOM 4735 CB ASP A 298 43.212 −5.434 15.531 1.00 13.70 A C ATOM 4738 CG ASP A 298 43.478 −6.162 16.835 1.00 13.63 A C ATOM 4739 OD1 ASP A 298 42.511 −6.539 17.530 1.00 14.13 A O ATOM 4740 OD2 ASP A 298 44.666 −6.368 17.156 1.00 13.89 A O ATOM 4741 C ASP A 298 42.044 −3.573 16.741 1.00 13.00 A C ATOM 4742 O ASP A 298 41.295 −3.681 17.710 1.00 12.88 A O ATOM 4744 N VAL A 299 42.959 −2.614 16.637 1.00 12.31 A N ATOM 4745 CA VAL A 299 43.312 −1.760 17.774 1.00 11.67 A C ATOM 4747 CB VAL A 299 44.805 −1.930 18.142 1.00 11.42 A C ATOM 4749 CG1 VAL A 299 45.071 −3.349 18.602 1.00 11.41 A C ATOM 4753 CG2 VAL A 299 45.703 −1.574 16.965 1.00 10.40 A C ATOM 4757 C VAL A 299 43.020 −0.267 17.587 1.00 11.59 A C ATOM 4758 O VAL A 299 42.551 0.385 18.524 1.00 11.49 A O ATOM 4760 N TYR A 300 43.289 0.268 16.394 1.00 11.13 A N ATOM 4761 CA TYR A 300 43.330 1.722 16.189 1.00 10.45 A C ATOM 4763 CB TYR A 300 44.389 2.094 15.139 1.00 9.99 A C ATOM 4766 CG TYR A 300 44.603 3.590 15.022 1.00 9.37 A C ATOM 4767 CD1 TYR A 300 45.202 4.309 16.055 1.00 9.54 A C ATOM 4769 CE1 TYR A 300 45.389 5.686 15.966 1.00 6.83 A C ATOM 4771 CZ TYR A 300 44.970 6.358 14.840 1.00 5.23 A C ATOM 4772 OH TYR A 300 45.155 7.715 14.752 1.00 3.12 A O ATOM 4774 CE2 TYR A 300 44.373 5.672 13.800 1.00 6.82 A C ATOM 4776 CD2 TYR A 300 44.188 4.292 13.896 1.00 8.25 A C ATOM 4778 C TYR A 300 41.989 2.370 15.821 1.00 10.48 A C ATOM 4779 O TYR A 300 41.675 3.448 16.317 1.00 10.25 A O ATOM 4781 N GLY A 301 41.209 1.729 14.956 1.00 11.04 A N ATOM 4782 CA GLY A 301 39.992 2.347 14.415 1.00 11.50 A C ATOM 4785 C GLY A 301 38.727 2.030 15.193 1.00 11.87 A C ATOM 4786 O GLY A 301 38.509 0.882 15.585 1.00 11.70 A O ATOM 4788 N THR A 302 37.887 3.045 15.411 1.00 12.42 A N ATOM 4789 CA THR A 302 36.572 2.829 16.024 1.00 13.04 A C ATOM 4791 CB THR A 302 35.913 4.137 16.546 1.00 13.14 A C ATOM 4793 OG1 THR A 302 35.606 5.009 15.452 1.00 14.40 A O ATOM 4795 CG2 THR A 302 36.826 4.852 17.535 1.00 12.53 A C ATOM 4799 C THR A 302 35.663 2.174 14.995 1.00 13.17 A C ATOM 4800 O THR A 302 35.965 2.180 13.803 1.00 12.57 A O ATOM 4802 N LEU A 303 34.551 1.613 15.456 1.00 13.95 A N ATOM 4803 CA LEU A 303 33.688 0.826 14.580 1.00 14.80 A C ATOM 4805 CB LEU A 303 32.567 0.138 15.375 1.00 14.99 A C ATOM 4808 CG LEU A 303 32.178 −1.259 14.876 1.00 15.81 A C ATOM 4810 CD1 LEU A 303 33.326 −2.239 15.080 1.00 16.28 A C ATOM 4814 CD2 LEU A 303 30.927 −1.768 15.578 1.00 17.42 A C ATOM 4818 C LEU A 303 33.114 1.690 13.456 1.00 15.44 A C ATOM 4819 O LEU A 303 33.109 1.275 12.295 1.00 15.80 A O ATOM 4821 N ASP A 304 32.659 2.896 13.803 1.00 15.85 A N ATOM 4822 CA ASP A 304 32.105 3.840 12.823 1.00 15.89 A C ATOM 4824 CB ASP A 304 31.645 5.137 13.509 1.00 16.11 A C ATOM 4827 CG ASP A 304 30.370 4.957 14.326 1.00 15.63 A C ATOM 4828 OD1 ASP A 304 29.443 4.266 13.852 1.00 13.49 A O ATOM 4829 OD2 ASP A 304 30.291 5.522 15.439 1.00 14.30 A O ATOM 4830 C ASP A 304 33.105 4.167 11.713 1.00 15.95 A C ATOM 4831 O ASP A 304 32.728 4.260 10.544 1.00 16.02 A O ATOM 4833 N GLU A 305 34.373 4.338 12.085 1.00 16.25 A N ATOM 4834 CA GLU A 305 35.447 4.580 11.113 1.00 16.33 A C ATOM 4836 CB GLU A 305 36.755 4.941 11.827 1.00 16.05 A C ATOM 4839 CG GLU A 305 36.716 6.292 12.527 1.00 17.49 A C ATOM 4842 CD GLU A 305 37.971 6.589 13.330 1.00 19.41 A C ATOM 4843 OE1 GLU A 305 38.649 5.636 13.773 1.00 21.25 A O ATOM 4844 OE2 GLU A 305 38.274 7.785 13.524 1.00 19.58 A O ATOM 4845 C GLU A 305 35.667 3.364 10.215 1.00 16.21 A C ATOM 4846 O GLU A 305 35.798 3.499 8.996 1.00 16.05 A O ATOM 4848 N LEU A 306 35.699 2.183 10.829 1.00 16.16 A N ATOM 4849 CA LEU A 306 35.911 0.930 10.107 1.00 15.88 A C ATOM 4851 CB LEU A 306 36.033 −0.235 11.089 1.00 15.78 A C ATOM 4854 CG LEU A 306 37.274 −0.232 11.976 1.00 15.34 A C ATOM 4856 CD1 LEU A 306 37.218 −1.417 12.928 1.00 16.17 A C ATOM 4860 CD2 LEU A 306 38.541 −0.256 11.134 1.00 14.22 A C ATOM 4864 C LEU A 306 34.799 0.635 9.104 1.00 16.02 A C ATOM 4865 O LEU A 306 35.065 0.112 8.019 1.00 15.90 A O ATOM 4867 N GLU A 307 33.561 0.960 9.471 1.00 16.02 A N ATOM 4868 CA GLU A 307 32.427 0.802 8.563 1.00 16.25 A C ATOM 4870 CB GLU A 307 31.130 1.274 9.224 1.00 16.45 A C ATOM 4873 CG GLU A 307 30.620 0.361 10.331 1.00 17.76 A C ATOM 4876 CD GLU A 307 29.869 −0.853 9.813 1.00 19.89 A C ATOM 4877 OE1 GLU A 307 29.047 −1.399 10.580 1.00 22.93 A O ATOM 4878 OE2 GLU A 307 30.093 −1.262 8.653 1.00 19.71 A O ATOM 4879 C GLU A 307 32.654 1.572 7.264 1.00 16.17 A C ATOM 4880 O GLU A 307 32.380 1.063 6.179 1.00 16.40 A O ATOM 4882 N LEU A 308 33.163 2.795 7.383 1.00 16.07 A N ATOM 4883 CA LEU A 308 33.456 3.620 6.213 1.00 15.87 A C ATOM 4885 CB LEU A 308 33.850 5.038 6.634 1.00 15.51 A C ATOM 4888 CG LEU A 308 32.759 5.841 7.341 1.00 14.36 A C ATOM 4890 CD1 LEU A 308 33.340 7.117 7.928 1.00 14.78 A C ATOM 4894 CD2 LEU A 308 31.618 6.151 6.386 1.00 12.42 A C ATOM 4898 C LEU A 308 34.559 2.995 5.359 1.00 15.95 A C ATOM 4899 O LEU A 308 34.422 2.896 4.140 1.00 16.08 A O ATOM 4901 N PHE A 309 35.644 2.566 5.997 1.00 15.86 A N ATOM 4902 CA PHE A 309 36.741 1.932 5.271 1.00 15.76 A C ATOM 4904 CB PHE A 309 37.879 1.539 6.213 1.00 15.23 A C ATOM 4907 CG PHE A 309 39.167 1.268 5.505 1.00 12.77 A C ATOM 4908 CD1 PHE A 309 40.023 2.308 5.187 1.00 11.18 A C ATOM 4910 CE1 PHE A 309 41.216 2.073 4.524 1.00 10.16 A C ATOM 4912 CZ PHE A 309 41.558 0.788 4.165 1.00 11.94 A C ATOM 4914 CE2 PHE A 309 40.705 −0.265 4.470 1.00 12.78 A C ATOM 4916 CD2 PHE A 309 39.515 −0.019 5.136 1.00 12.55 A C ATOM 4918 C PHE A 309 36.242 0.701 4.519 1.00 16.65 A C ATOM 4919 O PHE A 309 36.509 0.545 3.326 1.00 16.66 A O ATOM 4921 N THR A 310 35.515 −0.162 5.227 1.00 17.62 A N ATOM 4922 CA THR A 310 34.879 −1.337 4.626 1.00 18.17 A C ATOM 4924 CB THR A 310 33.943 −2.053 5.630 1.00 18.21 A C ATOM 4926 OG1 THR A 310 34.678 −2.429 6.802 1.00 18.07 A O ATOM 4928 CG2 THR A 310 33.321 −3.292 4.999 1.00 18.32 A C ATOM 4932 C THR A 310 34.057 −0.931 3.407 1.00 18.50 A C ATOM 4933 O THR A 310 34.199 −1.514 2.330 1.00 18.52 A O ATOM 4935 N ASP A 311 33.205 0.077 3.591 1.00 18.74 A N ATOM 4936 CA ASP A 311 32.368 0.609 2.515 1.00 18.56 A C ATOM 4938 CB ASP A 311 31.415 1.684 3.053 1.00 18.73 A C ATOM 4941 CG ASP A 311 30.562 2.306 1.966 1.00 19.68 A C ATOM 4942 OD1 ASP A 311 29.867 1.552 1.252 1.00 21.03 A O ATOM 4943 OD2 ASP A 311 30.591 3.548 1.824 1.00 20.12 A O ATOM 4944 C ASP A 311 33.221 1.186 1.389 1.00 17.98 A C ATOM 4945 O ASP A 311 32.919 0.981 0.218 1.00 17.81 A O ATOM 4947 N ALA A 312 34.288 1.895 1.754 1.00 17.60 A N ATOM 4948 CA ALA A 312 35.207 2.487 0.779 1.00 17.18 A C ATOM 4950 CB ALA A 312 36.287 3.290 1.493 1.00 17.04 A C ATOM 4954 C ALA A 312 35.840 1.431 −0.132 1.00 16.89 A C ATOM 4955 O ALA A 312 35.978 1.647 −1.336 1.00 16.28 A O ATOM 4957 N VAL A 313 36.215 0.292 0.446 1.00 17.08 A N ATOM 4958 CA VAL A 313 36.777 −0.819 −0.326 1.00 17.48 A C ATOM 4960 CB VAL A 313 37.595 −1.779 0.572 1.00 17.54 A C ATOM 4962 CG1 VAL A 313 38.729 −1.027 1.260 1.00 17.32 A C ATOM 4966 CG2 VAL A 313 38.156 −2.933 −0.239 1.00 17.14 A C ATOM 4970 C VAL A 313 35.686 −1.598 −1.076 1.00 17.77 A C ATOM 4971 O VAL A 313 35.932 −2.118 −2.164 1.00 17.70 A O ATOM 4973 N GLU A 314 34.486 −1.669 −0.501 1.00 18.26 A N ATOM 4974 CA GLU A 314 33.347 −2.332 −1.155 1.00 18.61 A C ATOM 4976 CB GLU A 314 32.125 −2.376 −0.229 1.00 18.86 A C ATOM 4979 CG GLU A 314 32.105 −3.539 0.747 1.00 20.58 A C ATOM 4982 CD GLU A 314 30.881 −3.524 1.649 1.00 24.15 A C ATOM 4983 OE1 GLU A 314 30.876 −4.268 2.652 1.00 28.09 A O ATOM 4984 OE2 GLU A 314 29.923 −2.771 1.361 1.00 24.84 A O ATOM 4985 C GLU A 314 32.929 −1.675 −2.470 1.00 18.45 A C ATOM 4986 O GLU A 314 32.453 −2.359 −3.375 1.00 18.12 A O ATOM 4988 N ARG A 315 33.089 −0.355 −2.563 1.00 18.81 A N ATOM 4989 CA ARG A 315 32.614 0.405 −3.724 1.00 19.28 A C ATOM 4991 CB ARG A 315 31.904 1.687 −3.276 1.00 19.73 A C ATOM 4994 CG ARG A 315 30.876 1.469 −2.149 1.00 22.35 A C ATOM 4997 CD ARG A 315 29.651 2.378 −2.247 1.00 25.41 A C ATOM 5000 NE ARG A 315 29.952 3.667 −2.867 1.00 29.17 A N ATOM 5002 CZ ARG A 315 30.616 4.665 −2.284 1.00 32.10 A C ATOM 5003 NH1 ARG A 315 30.828 5.789 −2.961 1.00 33.11 A N ATOM 5006 NH2 ARG A 315 31.072 4.555 −1.038 1.00 33.08 A N ATOM 5009 C ARG A 315 33.730 0.733 −4.717 1.00 18.91 A C ATOM 5010 O ARG A 315 33.484 0.805 −5.921 1.00 18.78 A O ATOM 5012 N TRP A 316 34.944 0.936 −4.209 1.00 18.94 A N ATOM 5013 CA TRP A 316 36.125 1.195 −5.046 1.00 18.73 A C ATOM 5015 CB TRP A 316 36.366 0.014 −6.002 1.00 18.53 A C ATOM 5018 CG TRP A 316 37.802 −0.166 −6.398 1.00 17.21 A C ATOM 5019 CD1 TRP A 316 38.330 −0.036 −7.649 1.00 16.88 A C ATOM 5021 NE1 TRP A 316 39.682 −0.275 −7.620 1.00 15.97 A N ATOM 5023 CE2 TRP A 316 40.051 −0.566 −6.334 1.00 15.80 A C ATOM 5024 CD2 TRP A 316 38.891 −0.507 −5.537 1.00 15.21 A C ATOM 5025 CE3 TRP A 316 38.999 −0.766 −4.167 1.00 16.69 A C ATOM 5027 CZ3 TRP A 316 40.245 −1.073 −3.643 1.00 17.30 A C ATOM 5029 CH2 TRP A 316 41.381 −1.127 −4.464 1.00 17.99 A C ATOM 5031 CZ2 TRP A 316 41.305 −0.873 −5.808 1.00 17.57 A C ATOM 5033 C TRP A 316 36.024 2.523 −5.818 1.00 18.77 A C ATOM 5034 O TRP A 316 36.569 2.660 −6.913 1.00 18.58 A O ATOM 5036 N ASP A 317 35.334 3.497 −5.229 1.00 19.02 A N ATOM 5037 CA ASP A 317 35.161 4.811 −5.835 1.00 19.48 A C ATOM 5039 CB ASP A 317 33.739 5.327 −5.573 1.00 19.49 A C ATOM 5042 CG ASP A 317 33.471 6.694 −6.199 1.00 19.09 A C ATOM 5043 OD1 ASP A 317 34.201 7.099 −7.129 1.00 19.20 A O ATOM 5044 OD2 ASP A 317 32.512 7.365 −5.758 1.00 17.19 A O ATOM 5045 C ASP A 317 36.202 5.767 −5.253 1.00 20.22 A C ATOM 5046 O ASP A 317 36.110 6.161 −4.088 1.00 20.57 A O ATOM 5048 N VAL A 318 37.188 6.135 −6.070 1.00 20.71 A N ATOM 5049 CA VAL A 318 38.276 7.016 −5.633 1.00 21.05 A C ATOM 5051 CB VAL A 318 39.423 7.038 −6.666 1.00 20.76 A C ATOM 5053 CG1 VAL A 318 40.690 7.613 −6.053 1.00 20.64 A C ATOM 5057 CG2 VAL A 318 39.017 7.812 −7.911 1.00 20.38 A C ATOM 5061 C VAL A 318 37.818 8.456 −5.370 1.00 21.99 A C ATOM 5062 O VAL A 318 38.528 9.222 −4.719 1.00 22.30 A O ATOM 5064 N ASN A 319 36.644 8.821 −5.885 1.00 22.84 A N ATOM 5065 CA ASN A 319 36.083 10.160 −5.684 1.00 23.25 A C ATOM 5067 CB ASN A 319 35.177 10.539 −6.862 1.00 23.24 A C ATOM 5070 CG ASN A 319 35.956 10.749 −8.159 1.00 23.11 A C ATOM 5071 OD1 ASN A 319 36.802 11.643 −8.255 1.00 22.22 A O ATOM 5072 ND2 ASN A 319 35.664 9.929 −9.166 1.00 20.47 A N ATOM 5075 C ASN A 319 35.323 10.305 −4.360 1.00 24.05 A C ATOM 5076 O ASN A 319 35.057 11.425 −3.924 1.00 24.48 A O ATOM 5078 N ALA A 320 34.978 9.180 −3.730 1.00 24.88 A N ATOM 5079 CA ALA A 320 34.347 9.180 −2.399 1.00 25.38 A C ATOM 5081 CB ALA A 320 33.373 8.017 −2.277 1.00 25.19 A C ATOM 5085 C ALA A 320 35.380 9.127 −1.261 1.00 25.94 A C ATOM 5086 O ALA A 320 35.010 9.092 −0.085 1.00 26.43 A O ATOM 5088 N ILE A 321 36.663 9.119 −1.624 1.00 26.12 A N ATOM 5089 CA ILE A 321 37.785 9.144 −0.674 1.00 26.16 A C ATOM 5091 CB ILE A 321 39.124 9.356 −1.440 1.00 26.28 A C ATOM 5093 CG1 ILE A 321 40.336 9.088 −0.551 1.00 25.99 A C ATOM 5096 CD1 ILE A 321 41.648 9.204 −1.300 1.00 25.33 A C ATOM 5100 CG2 ILE A 321 39.204 10.767 −2.021 1.00 27.21 A C ATOM 5104 C ILE A 321 37.651 10.218 0.420 1.00 26.28 A C ATOM 5105 O ILE A 321 38.083 10.002 1.553 1.00 26.33 A O ATOM 5107 N ASN A 322 37.046 11.361 0.078 1.00 26.31 A N ATOM 5108 CA ASN A 322 36.870 12.485 1.019 1.00 26.01 A C ATOM 5110 CB ASN A 322 36.659 13.804 0.248 1.00 25.94 A C ATOM 5113 CG ASN A 322 37.960 14.409 −0.261 1.00 26.56 A C ATOM 5114 OD1 ASN A 322 39.043 14.120 0.251 1.00 26.84 A O ATOM 5115 ND2 ASN A 322 37.854 15.266 −1.268 1.00 27.80 A N ATOM 5118 C ASN A 322 35.751 12.310 2.062 1.00 25.35 A C ATOM 5119 O ASN A 322 35.438 13.253 2.796 1.00 25.20 A O ATOM 5121 N ASP A 323 35.153 11.120 2.126 1.00 24.45 A N ATOM 5122 CA ASP A 323 34.220 10.778 3.204 1.00 24.14 A C ATOM 5124 CB ASP A 323 33.119 9.836 2.692 1.00 24.89 A C ATOM 5127 CG ASP A 323 32.096 10.547 1.811 1.00 26.83 A C ATOM 5128 OD1 ASP A 323 31.426 11.480 2.306 1.00 27.88 A O ATOM 5129 OD2 ASP A 323 31.952 10.162 0.629 1.00 29.53 A O ATOM 5130 C ASP A 323 34.945 10.136 4.394 1.00 22.55 A C ATOM 5131 O ASP A 323 34.408 10.098 5.504 1.00 22.17 A O ATOM 5133 N LEU A 324 36.162 9.644 4.157 1.00 21.03 A N ATOM 5134 CA LEU A 324 36.939 8.936 5.178 1.00 20.05 A C ATOM 5136 CB LEU A 324 37.933 7.973 4.518 1.00 19.99 A C ATOM 5139 CG LEU A 324 37.351 6.752 3.803 1.00 20.17 A C ATOM 5141 CD1 LEU A 324 38.422 6.076 2.962 1.00 20.22 A C ATOM 5145 CD2 LEU A 324 36.747 5.771 4.797 1.00 19.25 A C ATOM 5149 C LEU A 324 37.707 9.901 6.075 1.00 19.03 A C ATOM 5150 O LEU A 324 37.918 11.052 5.702 1.00 18.72 A O ATOM 5152 N PRO A 325 38.130 9.429 7.263 1.00 18.44 A N ATOM 5153 CA PRO A 325 39.010 10.213 8.122 1.00 18.19 A C ATOM 5155 CB PRO A 325 38.874 9.527 9.482 1.00 18.12 A C ATOM 5158 CG PRO A 325 38.558 8.121 9.159 1.00 18.05 A C ATOM 5161 CD PRO A 325 37.746 8.152 7.896 1.00 18.53 A C ATOM 5164 C PRO A 325 40.458 10.173 7.630 1.00 18.23 A C ATOM 5165 O PRO A 325 40.863 9.215 6.973 1.00 17.90 A O ATOM 5166 N ASP A 326 41.223 11.206 7.971 1.00 18.42 A N ATOM 5167 CA ASP A 326 42.555 11.441 7.400 1.00 18.51 A C ATOM 5169 CB ASP A 326 43.261 12.572 8.161 1.00 18.74 A C ATOM 5172 CG ASP A 326 42.691 13.945 7.832 1.00 20.90 A C ATOM 5173 OD1 ASP A 326 42.044 14.087 6.772 1.00 23.65 A O ATOM 5174 OD2 ASP A 326 42.891 14.886 8.632 1.00 23.58 A O ATOM 5175 C ASP A 326 43.466 10.209 7.307 1.00 18.04 A C ATOM 5176 O ASP A 326 44.037 9.950 6.246 1.00 18.16 A O ATOM 5178 N TYR A 327 43.605 9.453 8.393 1.00 17.28 A N ATOM 5179 CA TYR A 327 44.502 8.291 8.389 1.00 16.66 A C ATOM 5181 CB TYR A 327 44.728 7.753 9.807 1.00 16.33 A C ATOM 5184 CG TYR A 327 43.607 6.900 10.353 1.00 14.83 A C ATOM 5185 CD1 TYR A 327 42.558 7.471 11.061 1.00 14.91 A C ATOM 5187 CE1 TYR A 327 41.528 6.692 11.572 1.00 15.33 A C ATOM 5189 CZ TYR A 327 41.546 5.323 11.382 1.00 15.64 A C ATOM 5190 OH TYR A 327 40.524 4.554 11.893 1.00 15.59 A O ATOM 5192 CE2 TYR A 327 42.585 4.729 10.683 1.00 14.60 A C ATOM 5194 CD2 TYR A 327 43.607 5.518 10.176 1.00 13.91 A C ATOM 5196 C TYR A 327 44.004 7.180 7.454 1.00 16.77 A C ATOM 5197 O TYR A 327 44.801 6.394 6.934 1.00 16.95 A O ATOM 5199 N MET A 328 42.690 7.122 7.246 1.00 16.36 A N ATOM 5200 CA MET A 328 42.100 6.171 6.307 1.00 16.03 A C ATOM 5202 CB MET A 328 40.650 5.876 6.684 1.00 15.85 A C ATOM 5205 CG MET A 328 40.515 5.126 7.990 1.00 15.27 A C ATOM 5208 SD MET A 328 38.824 4.621 8.325 1.00 14.96 A S ATOM 5209 CE MET A 328 39.096 3.214 9.397 1.00 11.58 A C ATOM 5213 C MET A 328 42.171 6.665 4.862 1.00 16.28 A C ATOM 5214 O MET A 328 42.190 5.857 3.938 1.00 16.32 A O ATOM 5216 N LYS A 329 42.199 7.982 4.662 1.00 16.61 A N ATOM 5217 CA LYS A 329 42.364 8.542 3.320 1.00 16.78 A C ATOM 5219 CB LYS A 329 42.319 10.076 3.338 1.00 16.88 A C ATOM 5222 CG LYS A 329 40.977 10.672 3.743 1.00 19.25 A C ATOM 5225 CD LYS A 329 41.066 12.184 3.989 1.00 22.20 A C ATOM 5228 CE LYS A 329 40.917 12.990 2.701 1.00 23.60 A C ATOM 5231 NZ LYS A 329 41.054 14.461 2.934 1.00 23.47 A N ATOM 5235 C LYS A 329 43.699 8.076 2.752 1.00 16.51 A C ATOM 5236 O LYS A 329 43.750 7.459 1.687 1.00 16.65 A O ATOM 5238 N LEU A 330 44.770 8.355 3.492 1.00 16.06 A N ATOM 5239 CA LEU A 330 46.125 7.989 3.088 1.00 15.49 A C ATOM 5241 CB LEU A 330 47.142 8.516 4.110 1.00 15.41 A C ATOM 5244 CG LEU A 330 48.628 8.299 3.810 1.00 14.76 A C ATOM 5246 CD1 LEU A 330 49.024 8.972 2.505 1.00 13.80 A C ATOM 5250 CD2 LEU A 330 49.481 8.812 4.960 1.00 13.92 A C ATOM 5254 C LEU A 330 46.283 6.478 2.927 1.00 15.10 A C ATOM 5255 O LEU A 330 47.011 6.020 2.049 1.00 14.96 A O ATOM 5257 N CYS A 331 45.600 5.710 3.772 1.00 14.87 A N ATOM 5258 CA CYS A 331 45.696 4.248 3.732 1.00 14.79 A C ATOM 5260 CB CYS A 331 45.193 3.642 5.047 1.00 15.05 A C ATOM 5263 SG CYS A 331 45.475 1.867 5.196 1.00 16.22 A S ATOM 5265 C CYS A 331 44.919 3.661 2.552 1.00 13.61 A C ATOM 5266 O CYS A 331 45.455 2.861 1.787 1.00 13.77 A O ATOM 5268 N PHE A 332 43.661 4.067 2.415 1.00 12.37 A N ATOM 5269 CA PHE A 332 42.796 3.589 1.339 1.00 11.68 A C ATOM 5271 CB PHE A 332 41.430 4.282 1.415 1.00 11.85 A C ATOM 5274 CG PHE A 332 40.527 3.977 0.255 1.00 10.54 A C ATOM 5275 CD1 PHE A 332 39.892 2.752 0.163 1.00 9.36 A C ATOM 5277 CE1 PHE A 332 39.065 2.466 −0.905 1.00 11.01 A C ATOM 5279 CZ PHE A 332 38.862 3.413 −1.897 1.00 11.31 A C ATOM 5281 CE2 PHE A 332 39.489 4.639 −1.815 1.00 9.89 A C ATOM 5283 CD2 PHE A 332 40.315 4.917 −0.744 1.00 10.03 A C ATOM 5285 C PHE A 332 43.413 3.812 −0.042 1.00 11.23 A C ATOM 5286 O PHE A 332 43.527 2.878 −0.832 1.00 11.12 A O ATOM 5288 N LEU A 333 43.808 5.051 −0.322 1.00 10.61 A N ATOM 5289 CA LEU A 333 44.354 5.417 −1.632 1.00 10.12 A C ATOM 5291 CB LEU A 333 44.677 6.916 −1.680 1.00 9.81 A C ATOM 5294 CG LEU A 333 45.111 7.515 −3.022 1.00 8.38 A C ATOM 5296 CD1 LEU A 333 44.113 7.206 −4.128 1.00 7.03 A C ATOM 5300 CD2 LEU A 333 45.299 9.017 −2.881 1.00 5.80 A C ATOM 5304 C LEU A 333 45.598 4.605 −1.978 1.00 10.21 A C ATOM 5305 O LEU A 333 45.791 4.229 −3.133 1.00 9.84 A O ATOM 5307 N ALA A 334 46.432 4.342 −0.972 1.00 10.86 A N ATOM 5308 CA ALA A 334 47.645 3.538 −1.140 1.00 11.33 A C ATOM 5310 CB ALA A 334 48.442 3.504 0.155 1.00 11.25 A C ATOM 5314 C ALA A 334 47.302 2.120 −1.582 1.00 11.86 A C ATOM 5315 O ALA A 334 47.965 1.552 −2.453 1.00 11.99 A O ATOM 5317 N LEU A 335 46.273 1.552 −0.961 1.00 12.36 A N ATOM 5318 CA LEU A 335 45.726 0.262 −1.371 1.00 12.61 A C ATOM 5320 CB LEU A 335 44.651 −0.193 −0.375 1.00 12.56 A C ATOM 5323 CG LEU A 335 43.849 −1.461 −0.677 1.00 12.43 A C ATOM 5325 CD1 LEU A 335 44.764 −2.659 −0.871 1.00 13.39 A C ATOM 5329 CD2 LEU A 335 42.863 −1.712 0.447 1.00 9.98 A C ATOM 5333 C LEU A 335 45.136 0.383 −2.772 1.00 12.75 A C ATOM 5334 O LEU A 335 45.446 −0.411 −3.655 1.00 12.66 A O ATOM 5336 N TYR A 336 44.300 1.400 −2.961 1.00 13.37 A N ATOM 5337 CA TYR A 336 43.602 1.636 −4.225 1.00 13.86 A C ATOM 5339 CB TYR A 336 42.847 2.970 −4.167 1.00 14.27 A C ATOM 5342 CG TYR A 336 41.953 3.234 −5.357 1.00 14.40 A C ATOM 5343 CD1 TYR A 336 40.743 2.569 −5.499 1.00 14.78 A C ATOM 5345 CE1 TYR A 336 39.916 2.810 −6.586 1.00 13.90 A C ATOM 5347 CZ TYR A 336 40.293 3.725 −7.545 1.00 11.73 A C ATOM 5348 OH TYR A 336 39.473 3.962 −8.623 1.00 8.69 A O ATOM 5350 CE2 TYR A 336 41.488 4.405 −7.423 1.00 13.24 A C ATOM 5352 CD2 TYR A 336 42.310 4.158 −6.334 1.00 14.34 A C ATOM 5354 C TYR A 336 44.548 1.622 −5.422 1.00 13.95 A C ATOM 5355 O TYR A 336 44.305 0.907 −6.397 1.00 14.01 A O ATOM 5357 N ASN A 337 45.624 2.405 −5.332 1.00 13.83 A N ATOM 5358 CA ASN A 337 46.605 2.519 −6.416 1.00 13.77 A C ATOM 5360 CB ASN A 337 47.606 3.646 −6.127 1.00 13.87 A C ATOM 5363 CG ASN A 337 47.035 5.023 −6.408 1.00 15.61 A C ATOM 5364 OD1 ASN A 337 46.144 5.179 −7.243 1.00 19.22 A O ATOM 5365 ND2 ASN A 337 47.557 6.035 −5.719 1.00 16.23 A N ATOM 5368 C ASN A 337 47.362 1.221 −6.689 1.00 13.58 A C ATOM 5369 O ASN A 337 47.512 0.822 −7.841 1.00 13.59 A O ATOM 5371 N THR A 338 47.831 0.565 −5.631 1.00 13.35 A N ATOM 5372 CA THR A 338 48.600 −0.674 −5.770 1.00 13.08 A C ATOM 5374 CB THR A 338 49.056 −1.211 −4.399 1.00 12.97 A C ATOM 5376 OG1 THR A 338 49.664 −0.156 −3.645 1.00 11.42 A O ATOM 5378 CG2 THR A 338 50.053 −2.343 −4.574 1.00 13.23 A C ATOM 5382 C THR A 338 47.803 −1.766 −6.487 1.00 13.11 A C ATOM 5383 O THR A 338 48.347 −2.490 −7.321 1.00 12.90 A O ATOM 5385 N ILE A 339 46.515 −1.867 −6.163 1.00 13.33 A N ATOM 5386 CA ILE A 339 45.632 −2.852 −6.786 1.00 13.78 A C ATOM 5388 CB ILE A 339 44.286 −2.979 −6.033 1.00 13.62 A C ATOM 5390 CG1 ILE A 339 44.507 −3.429 −4.585 1.00 13.37 A C ATOM 5393 CD1 ILE A 339 45.261 −4.721 −4.450 1.00 11.21 A C ATOM 5397 CG2 ILE A 339 43.364 −3.962 −6.740 1.00 13.25 A C ATOM 5401 C ILE A 339 45.356 −2.486 −8.242 1.00 14.51 A C ATOM 5402 O ILE A 339 45.444 −3.338 −9.127 1.00 14.76 A O ATOM 5404 N ASN A 340 45.025 −1.220 −8.485 1.00 15.03 A N ATOM 5405 CA ASN A 340 44.810 −0.734 −9.847 1.00 15.47 A C ATOM 5407 CB ASN A 340 44.412 0.741 −9.843 1.00 15.26 A C ATOM 5410 CG ASN A 340 43.012 0.971 −9.315 1.00 15.69 A C ATOM 5411 OD1 ASN A 340 42.256 0.030 −9.065 1.00 14.77 A O ATOM 5412 ND2 ASN A 340 42.656 2.236 −9.149 1.00 17.78 A N ATOM 5415 C ASN A 340 46.030 −0.918 −10.745 1.00 16.40 A C ATOM 5416 O ASN A 340 45.882 −1.126 −11.950 1.00 17.11 A O ATOM 5418 N GLU A 341 47.227 −0.839 −10.161 1.00 16.74 A N ATOM 5419 CA GLU A 341 48.467 −1.016 −10.919 1.00 16.76 A C ATOM 5421 CB GLU A 341 49.645 −0.371 −10.193 1.00 17.38 A C ATOM 5424 CG GLU A 341 49.525 1.142 −10.115 1.00 20.36 A C ATOM 5427 CD GLU A 341 50.747 1.812 −9.519 1.00 25.20 A C ATOM 5428 OE1 GLU A 341 51.715 1.100 −9.164 1.00 27.46 A O ATOM 5429 OE2 GLU A 341 50.731 3.061 −9.411 1.00 26.48 A O ATOM 5430 C GLU A 341 48.765 −2.480 −11.232 1.00 15.62 A C ATOM 5431 O GLU A 341 49.288 −2.782 −12.305 1.00 15.57 A O ATOM 5433 N ILE A 342 48.439 −3.390 −10.316 1.00 14.59 A N ATOM 5434 CA ILE A 342 48.519 −4.819 −10.637 1.00 14.45 A C ATOM 5436 CB ILE A 342 48.289 −5.731 −9.410 1.00 14.11 A C ATOM 5438 CG1 ILE A 342 49.421 −5.570 −8.398 1.00 14.65 A C ATOM 5441 CD1 ILE A 342 49.239 −6.395 −7.145 1.00 14.72 A C ATOM 5445 CG2 ILE A 342 48.233 −7.189 −9.837 1.00 13.46 A C ATOM 5449 C ILE A 342 47.490 −5.145 −11.724 1.00 14.17 A C ATOM 5450 O ILE A 342 47.784 −5.884 −12.668 1.00 14.44 A O ATOM 5452 N ALA A 343 46.293 −4.576 −11.586 1.00 13.41 A N ATOM 5453 CA ALA A 343 45.229 −4.730 −12.577 1.00 12.37 A C ATOM 5455 CB ALA A 343 43.979 −3.989 −12.127 1.00 12.12 A C ATOM 5459 C ALA A 343 45.671 −4.234 −13.952 1.00 11.86 A C ATOM 5460 O ALA A 343 45.270 −4.793 −14.971 1.00 11.95 A O ATOM 5462 N TYR A 344 46.491 −3.182 −13.974 1.00 11.28 A N ATOM 5463 CA TYR A 344 47.076 −2.685 −15.219 1.00 10.66 A C ATOM 5465 CB TYR A 344 47.703 −1.298 −15.027 1.00 10.43 A C ATOM 5468 CG TYR A 344 48.443 −0.803 −16.250 1.00 8.34 A C ATOM 5469 CD1 TYR A 344 47.782 −0.096 −17.248 1.00 6.31 A C ATOM 5471 CE1 TYR A 344 48.453 0.350 −18.377 1.00 5.53 A C ATOM 5473 CZ TYR A 344 49.802 0.088 −18.520 1.00 6.31 A C ATOM 5474 OH TYR A 344 50.471 0.530 −19.638 1.00 4.56 A O ATOM 5476 CE2 TYR A 344 50.482 −0.614 −17.542 1.00 7.74 A C ATOM 5478 CD2 TYR A 344 49.801 −1.056 −16.416 1.00 7.79 A C ATOM 5480 C TYR A 344 48.124 −3.666 −15.725 1.00 10.67 A C ATOM 5481 O TYR A 344 48.084 −4.078 −16.881 1.00 10.32 A O ATOM 5483 N ASP A 345 49.060 −4.033 −14.853 1.00 11.33 A N ATOM 5484 CA ASP A 345 50.108 −5.004 −15.192 1.00 11.99 A C ATOM 5486 CB ASP A 345 50.939 −5.377 −13.948 1.00 12.01 A C ATOM 5489 CG ASP A 345 51.945 −4.297 −13.553 1.00 12.59 A C ATOM 5490 OD1 ASP A 345 52.076 −3.277 −14.269 1.00 11.18 A O ATOM 5491 OD2 ASP A 345 52.615 −4.483 −12.513 1.00 12.55 A O ATOM 5492 C ASP A 345 49.530 −6.275 −15.829 1.00 11.93 A C ATOM 5493 O ASP A 345 50.123 −6.833 −16.758 1.00 11.83 A O ATOM 5495 N ASN A 346 48.378 −6.722 −15.329 1.00 11.62 A N ATOM 5496 CA ASN A 346 47.709 −7.906 −15.868 1.00 11.58 A C ATOM 5498 CB ASN A 346 46.774 −8.521 −14.825 1.00 11.15 A C ATOM 5501 CG ASN A 346 47.516 −9.376 −13.819 1.00 12.26 A C ATOM 5502 OD1 ASN A 346 48.097 −10.404 −14.173 1.00 14.81 A O ATOM 5503 ND2 ASN A 346 47.502 −8.961 −12.557 1.00 12.75 A N ATOM 5506 C ASN A 346 46.956 −7.634 −17.171 1.00 11.92 A C ATOM 5507 O ASN A 346 46.898 −8.503 −18.041 1.00 12.36 A O ATOM 5509 N LEU A 347 46.384 −6.440 −17.311 1.00 11.92 A N ATOM 5510 CA LEU A 347 45.734 −6.057 −18.566 1.00 11.64 A C ATOM 5512 CB LEU A 347 44.961 −4.740 −18.413 1.00 11.58 A C ATOM 5515 CG LEU A 347 44.059 −4.336 −19.588 1.00 10.95 A C ATOM 5517 CD1 LEU A 347 42.907 −5.312 −19.745 1.00 10.27 A C ATOM 5521 CD2 LEU A 347 43.533 −2.919 −19.413 1.00 9.70 A C ATOM 5525 C LEU A 347 46.772 −5.936 −19.680 1.00 11.59 A C ATOM 5526 O LEU A 347 46.514 −6.330 −20.814 1.00 11.64 A O ATOM 5528 N LYS A 348 47.946 −5.405 −19.348 1.00 11.60 A N ATOM 5529 CA LYS A 348 49.022 −5.244 −20.321 1.00 11.67 A C ATOM 5531 CB LYS A 348 50.169 −4.411 −19.731 1.00 11.61 A C ATOM 5534 CG LYS A 348 51.223 −4.009 −20.758 1.00 12.03 A C ATOM 5537 CD LYS A 348 52.290 −3.072 −20.194 1.00 12.25 A C ATOM 5540 CE LYS A 348 53.520 −3.809 −19.672 1.00 12.33 A C ATOM 5543 NZ LYS A 348 53.341 −4.292 −18.278 1.00 14.05 A N ATOM 5547 C LYS A 348 49.558 −6.595 −20.794 1.00 11.72 A C ATOM 5548 O LYS A 348 49.582 −6.876 −21.990 1.00 11.62 A O ATOM 5550 N ASP A 349 49.969 −7.430 −19.847 1.00 12.09 A N ATOM 5551 CA ASP A 349 50.714 −8.650 −20.162 1.00 12.80 A C ATOM 5553 CB ASP A 349 51.664 −8.986 −19.006 1.00 13.12 A C ATOM 5556 CG ASP A 349 52.656 −7.862 −18.717 1.00 14.20 A C ATOM 5557 OD1 ASP A 349 52.969 −7.085 −19.650 1.00 11.97 A O ATOM 5558 OD2 ASP A 349 53.120 −7.756 −17.558 1.00 15.26 A O ATOM 5559 C ASP A 349 49.851 −9.873 −20.506 1.00 12.85 A C ATOM 5560 O ASP A 349 50.365 −10.840 −21.071 1.00 12.41 A O ATOM 5562 N LYS A 350 48.560 −9.833 −20.169 1.00 13.16 A N ATOM 5563 CA LYS A 350 47.635 −10.942 −20.471 1.00 13.31 A C ATOM 5565 CB LYS A 350 47.101 −11.564 −19.179 1.00 13.49 A C ATOM 5568 CG LYS A 350 48.180 −12.050 −18.233 1.00 15.19 A C ATOM 5571 CD LYS A 350 47.570 −12.759 −17.044 1.00 17.31 A C ATOM 5574 CE LYS A 350 48.620 −13.131 −16.015 1.00 17.74 A C ATOM 5577 NZ LYS A 350 47.980 −13.734 −14.818 1.00 17.79 A N ATOM 5581 C LYS A 350 46.451 −10.554 −21.358 1.00 12.84 A C ATOM 5582 O LYS A 350 45.896 −11.406 −22.048 1.00 12.55 A O ATOM 5584 N GLY A 351 46.056 −9.285 −21.331 1.00 13.03 A N ATOM 5585 CA GLY A 351 44.914 −8.816 −22.115 1.00 13.29 A C ATOM 5588 C GLY A 351 43.595 −9.148 −21.448 1.00 13.31 A C ATOM 5589 O GLY A 351 42.623 −9.491 −22.116 1.00 13.20 A O ATOM 5591 N GLU A 352 43.567 −9.047 −20.124 1.00 13.73 A N ATOM 5592 CA GLU A 352 42.388 −9.384 −19.342 1.00 14.52 A C ATOM 5594 CB GLU A 352 42.547 −10.770 −18.698 1.00 14.81 A C ATOM 5597 CG GLU A 352 42.906 −11.923 −19.656 1.00 15.61 A C ATOM 5600 CD GLU A 352 41.735 −12.422 −20.503 1.00 15.97 A C ATOM 5601 OE1 GLU A 352 40.627 −11.845 −20.425 1.00 15.33 A O ATOM 5602 OE2 GLU A 352 41.934 −13.408 −21.249 1.00 14.04 A O ATOM 5603 C GLU A 352 42.187 −8.335 −18.249 1.00 14.94 A C ATOM 5604 O GLU A 352 43.153 −7.891 −17.621 1.00 14.91 A O ATOM 5606 N ASN A 353 40.933 −7.944 −18.028 1.00 15.09 A N ATOM 5607 CA ASN A 353 40.579 −7.054 −16.924 1.00 15.05 A C ATOM 5609 CB ASN A 353 39.393 −6.167 −17.315 1.00 15.19 A C ATOM 5612 CG ASN A 353 39.132 −5.055 −16.314 1.00 14.51 A C ATOM 5613 OD1 ASN A 353 39.523 −5.135 −15.151 1.00 12.06 A O ATOM 5614 ND2 ASN A 353 38.459 −4.007 −16.769 1.00 16.67 A N ATOM 5617 C ASN A 353 40.238 −7.895 −15.696 1.00 14.95 A C ATOM 5618 O ASN A 353 39.198 −8.554 −15.662 1.00 15.14 A O ATOM 5620 N ILE A 354 41.118 −7.863 −14.695 1.00 14.71 A N ATOM 5621 CA ILE A 354 40.940 −8.652 −13.472 1.00 14.50 A C ATOM 5623 CB ILE A 354 42.138 −9.614 −13.238 1.00 14.70 A C ATOM 5625 CG1 ILE A 354 43.430 −8.840 −12.954 1.00 14.73 A C ATOM 5628 CD1 ILE A 354 44.527 −9.706 −12.397 1.00 13.59 A C ATOM 5632 CG2 ILE A 354 42.333 −10.530 −14.441 1.00 15.18 A C ATOM 5636 C ILE A 354 40.736 −7.791 −12.221 1.00 14.26 A C ATOM 5637 O ILE A 354 40.839 −8.290 −11.104 1.00 14.39 A O ATOM 5639 N LEU A 355 40.440 −6.507 −12.401 1.00 14.54 A N ATOM 5640 CA LEU A 355 40.244 −5.601 −11.266 1.00 14.48 A C ATOM 5642 CB LEU A 355 40.026 −4.157 −11.748 1.00 14.01 A C ATOM 5645 CG LEU A 355 39.868 −3.068 −10.679 1.00 13.56 A C ATOM 5647 CD1 LEU A 355 41.000 −3.113 −9.666 1.00 13.71 A C ATOM 5651 CD2 LEU A 355 39.786 −1.687 −11.320 1.00 12.08 A C ATOM 5655 C LEU A 355 39.103 −6.042 −10.335 1.00 14.97 A C ATOM 5656 O LEU A 355 39.248 −5.951 −9.116 1.00 15.16 A O ATOM 5658 N PRO A 356 37.976 −6.532 −10.899 1.00 15.42 A N ATOM 5659 CA PRO A 356 36.863 −6.986 −10.057 1.00 15.69 A C ATOM 5661 CB PRO A 356 35.785 −7.372 −11.079 1.00 15.69 A C ATOM 5664 CG PRO A 356 36.124 −6.623 −12.292 1.00 15.33 A C ATOM 5667 CD PRO A 356 37.610 −6.580 −12.326 1.00 15.51 A C ATOM 5670 C PRO A 356 37.177 −8.185 −9.154 1.00 15.96 A C ATOM 5671 O PRO A 356 36.545 −8.342 −8.107 1.00 16.29 A O ATOM 5672 N TYR A 357 38.130 −9.023 −9.556 1.00 15.86 A N ATOM 5673 CA TYR A 357 38.504 −10.198 −8.762 1.00 16.04 A C ATOM 5675 CB TYR A 357 39.099 −11.298 −9.651 1.00 16.10 A C ATOM 5678 CG TYR A 357 38.332 −11.505 −10.938 1.00 17.77 A C ATOM 5679 CD1 TYR A 357 36.958 −11.732 −10.921 1.00 18.41 A C ATOM 5681 CE1 TYR A 357 36.244 −11.912 −12.099 1.00 18.01 A C ATOM 5683 CZ TYR A 357 36.905 −11.864 −13.311 1.00 18.22 A C ATOM 5684 OH TYR A 357 36.207 −12.043 −14.479 1.00 19.76 A O ATOM 5686 CE2 TYR A 357 38.269 −11.641 −13.356 1.00 18.63 A C ATOM 5688 CD2 TYR A 357 38.975 −11.460 −12.173 1.00 18.68 A C ATOM 5690 C TYR A 357 39.489 −9.810 −7.661 1.00 15.60 A C ATOM 5691 O TYR A 357 39.448 −10.361 −6.562 1.00 15.71 A O ATOM 5693 N LEU A 358 40.371 −8.861 −7.965 1.00 15.17 A N ATOM 5694 CA LEU A 358 41.318 −8.345 −6.983 1.00 14.66 A C ATOM 5696 CB LEU A 358 42.383 −7.471 −7.655 1.00 14.49 A C ATOM 5699 CG LEU A 358 43.348 −8.179 −8.610 1.00 13.67 A C ATOM 5701 CD1 LEU A 358 44.231 −7.165 −9.319 1.00 13.09 A C ATOM 5705 CD2 LEU A 358 44.198 −9.197 −7.873 1.00 11.60 A C ATOM 5709 C LEU A 358 40.597 −7.548 −5.899 1.00 14.57 A C ATOM 5710 O LEU A 358 40.844 −7.764 −4.713 1.00 15.41 A O ATOM 5712 N THR A 359 39.703 −6.644 −6.304 1.00 13.71 A N ATOM 5713 CA THR A 359 39.002 −5.768 −5.354 1.00 13.19 A C ATOM 5715 CB THR A 359 38.347 −4.560 −6.058 1.00 13.29 A C ATOM 5717 OG1 THR A 359 37.390 −5.020 −7.020 1.00 15.24 A O ATOM 5719 CG2 THR A 359 39.399 −3.705 −6.748 1.00 12.12 A C ATOM 5723 C THR A 359 37.933 −6.490 −4.528 1.00 12.69 A C ATOM 5724 O THR A 359 37.545 −6.008 −3.464 1.00 12.15 A O ATOM 5726 N LYS A 360 37.456 −7.634 −5.019 1.00 12.46 A N ATOM 5727 CA LYS A 360 36.519 −8.471 −4.263 1.00 12.16 A C ATOM 5729 CB LYS A 360 35.845 −9.498 −5.180 1.00 12.44 A C ATOM 5732 CG LYS A 360 34.793 −10.378 −4.499 1.00 13.59 A C ATOM 5735 CD LYS A 360 33.591 −9.569 −4.027 1.00 14.74 A C ATOM 5738 CE LYS A 360 32.450 −10.472 −3.579 1.00 15.45 A C ATOM 5741 NZ LYS A 360 31.179 −9.724 −3.364 1.00 15.06 A N ATOM 5745 C LYS A 360 37.235 −9.185 −3.118 1.00 11.29 A C ATOM 5746 O LYS A 360 36.666 −9.365 −2.042 1.00 11.08 A O ATOM 5748 N ALA A 361 38.476 −9.598 −3.359 1.00 10.61 A N ATOM 5749 CA ALA A 361 39.304 −10.206 −2.318 1.00 10.70 A C ATOM 5751 CB ALA A 361 40.628 −10.673 −2.900 1.00 11.07 A C ATOM 5755 C ALA A 361 39.553 −9.222 −1.181 1.00 10.58 A C ATOM 5756 O ALA A 361 39.661 −9.619 −0.019 1.00 10.13 A O ATOM 5758 N TRP A 362 39.643 −7.941 −1.534 1.00 10.54 A N ATOM 5759 CA TRP A 362 39.859 −6.868 −0.568 1.00 10.37 A C ATOM 5761 CB TRP A 362 40.577 −5.696 −1.236 1.00 9.72 A C ATOM 5764 CG TRP A 362 42.045 −5.882 −1.233 1.00 9.03 A C ATOM 5765 CD1 TRP A 362 42.838 −6.216 −2.288 1.00 9.07 A C ATOM 5767 NE1 TRP A 362 44.147 −6.312 −1.883 1.00 8.13 A N ATOM 5769 CE2 TRP A 362 44.215 −6.045 −0.542 1.00 7.66 A C ATOM 5770 CD2 TRP A 362 42.907 −5.775 −0.099 1.00 7.66 A C ATOM 5771 CE3 TRP A 362 42.699 −5.472 1.250 1.00 7.22 A C ATOM 5773 CZ3 TRP A 362 43.784 −5.446 2.099 1.00 7.74 A C ATOM 5775 CH2 TRP A 362 45.076 −5.718 1.629 1.00 9.54 A C ATOM 5777 CZ2 TRP A 362 45.310 −6.018 0.314 1.00 9.02 A C ATOM 5779 C TRP A 362 38.570 −6.394 0.099 1.00 11.16 A C ATOM 5780 O TRP A 362 38.588 −6.007 1.267 1.00 11.42 A O ATOM 5782 N ALA A 363 37.462 −6.416 −0.639 1.00 11.67 A N ATOM 5783 CA ALA A 363 36.151 −6.099 −0.070 1.00 12.00 A C ATOM 5785 CB ALA A 363 35.103 −5.985 −1.169 1.00 11.90 A C ATOM 5789 C ALA A 363 35.738 −7.162 0.941 1.00 12.69 A C ATOM 5790 O ALA A 363 35.096 −6.857 1.944 1.00 12.73 A O ATOM 5792 N ASP A 364 36.112 −8.409 0.670 1.00 13.63 A N ATOM 5793 CA ASP A 364 35.763 −9.523 1.544 1.00 14.66 A C ATOM 5795 CB ASP A 364 35.734 −10.838 0.754 1.00 15.17 A C ATOM 5798 CG ASP A 364 34.559 −10.916 −0.223 1.00 17.28 A C ATOM 5799 OD1 ASP A 364 33.578 −10.155 −0.061 1.00 17.21 A O ATOM 5800 OD2 ASP A 364 34.618 −11.751 −1.154 1.00 20.88 A O ATOM 5801 C ASP A 364 36.711 −9.635 2.738 1.00 14.83 A C ATOM 5802 O ASP A 364 36.275 −9.968 3.841 1.00 15.19 A O ATOM 5804 N LEU A 365 37.998 −9.359 2.527 1.00 14.97 A N ATOM 5805 CA LEU A 365 38.978 −9.400 3.620 1.00 14.98 A C ATOM 5807 CB LEU A 365 40.399 −9.149 3.100 1.00 14.64 A C ATOM 5810 CG LEU A 365 41.521 −9.152 4.146 1.00 13.12 A C ATOM 5812 CD1 LEU A 365 41.596 −10.491 4.852 1.00 12.43 A C ATOM 5816 CD2 LEU A 365 42.861 −8.812 3.514 1.00 13.28 A C ATOM 5820 C LEU A 365 38.632 −8.367 4.685 1.00 15.67 A C ATOM 5821 O LEU A 365 38.742 −8.637 5.884 1.00 16.08 A O ATOM 5823 N CYS A 366 38.216 −7.187 4.234 1.00 16.03 A N ATOM 5824 CA CYS A 366 37.820 −6.108 5.130 1.00 16.51 A C ATOM 5826 CB CYS A 366 37.723 −4.784 4.363 1.00 16.60 A C ATOM 5829 SG CYS A 366 39.333 −4.159 3.767 1.00 17.69 A S ATOM 5831 C CYS A 366 36.505 −6.430 5.850 1.00 17.00 A C ATOM 5832 O CYS A 366 36.377 −6.170 7.047 1.00 17.59 A O ATOM 5834 N ASN A 367 35.541 −7.008 5.132 1.00 17.21 A N ATOM 5835 CA ASN A 367 34.291 −7.476 5.757 1.00 17.08 A C ATOM 5837 CB ASN A 367 33.275 −7.939 4.703 1.00 17.09 A C ATOM 5840 CG ASN A 367 32.260 −6.863 4.354 1.00 17.63 A C ATOM 5841 OD1 ASN A 367 31.791 −6.127 5.225 1.00 17.70 A O ATOM 5842 ND2 ASN A 367 31.903 −6.778 3.076 1.00 17.33 A N ATOM 5845 C ASN A 367 34.514 −8.590 6.782 1.00 17.07 A C ATOM 5846 O ASN A 367 33.684 −8.793 7.670 1.00 17.00 A O ATOM 5848 N ALA A 368 35.627 −9.311 6.646 1.00 16.97 A N ATOM 5849 CA ALA A 368 36.051 −10.287 7.647 1.00 16.97 A C ATOM 5851 CB ALA A 368 37.167 −11.156 7.093 1.00 16.96 A C ATOM 5855 C ALA A 368 36.505 −9.598 8.937 1.00 17.11 A C ATOM 5856 O ALA A 368 36.112 −10.006 10.034 1.00 16.89 A O ATOM 5858 N PHE A 369 37.332 −8.559 8.798 1.00 17.06 A N ATOM 5859 CA PHE A 369 37.834 −7.796 9.948 1.00 17.07 A C ATOM 5861 CB PHE A 369 38.876 −6.756 9.517 1.00 17.09 A C ATOM 5864 CG PHE A 369 40.163 −7.336 9.004 1.00 17.47 A C ATOM 5865 CD1 PHE A 369 40.847 −8.307 9.722 1.00 19.16 A C ATOM 5867 CE1 PHE A 369 42.047 −8.826 9.253 1.00 19.68 A C ATOM 5869 CZ PHE A 369 42.583 −8.361 8.064 1.00 19.22 A C ATOM 5871 CE2 PHE A 369 41.917 −7.383 7.347 1.00 19.11 A C ATOM 5873 CD2 PHE A 369 40.717 −6.872 7.820 1.00 17.84 A C ATOM 5875 C PHE A 369 36.721 −7.061 10.694 1.00 17.02 A C ATOM 5876 O PHE A 369 36.748 −6.961 11.924 1.00 17.17 A O ATOM 5878 N LEU A 370 35.763 −6.521 9.945 1.00 16.86 A N ATOM 5879 CA LEU A 370 34.624 −5.827 10.543 1.00 16.90 A C ATOM 5881 CB LEU A 370 33.710 −5.241 9.462 1.00 17.00 A C ATOM 5884 CG LEU A 370 32.790 −4.104 9.913 1.00 16.77 A C ATOM 5886 CD1 LEU A 370 33.545 −2.782 9.908 1.00 17.03 A C ATOM 5890 CD2 LEU A 370 31.557 −4.011 9.027 1.00 17.46 A C ATOM 5894 C LEU A 370 33.843 −6.802 11.415 1.00 17.08 A C ATOM 5895 O LEU A 370 33.438 −6.464 12.526 1.00 16.72 A O ATOM 5897 N GLN A 371 33.651 −8.016 10.899 1.00 17.46 A N ATOM 5898 CA GLN A 371 32.961 −9.077 11.626 1.00 17.49 A C ATOM 5900 CB GLN A 371 32.719 −10.279 10.708 1.00 17.34 A C ATOM 5903 CG GLN A 371 31.916 −11.410 11.344 1.00 17.48 A C ATOM 5906 CD GLN A 371 30.512 −10.990 11.732 1.00 17.14 A C ATOM 5907 OE1 GLN A 371 30.267 −10.572 12.863 1.00 17.53 A O ATOM 5908 NE2 GLN A 371 29.582 −11.091 10.789 1.00 16.59 A N ATOM 5911 C GLN A 371 33.741 −9.506 12.869 1.00 17.91 A C ATOM 5912 O GLN A 371 33.140 −9.800 13.901 1.00 18.11 A O ATOM 5914 N GLU A 372 35.070 −9.549 12.767 1.00 18.39 A N ATOM 5915 CA GLU A 372 35.926 −9.854 13.921 1.00 18.81 A C ATOM 5917 CB GLU A 372 37.388 −10.058 13.498 1.00 19.35 A C ATOM 5920 CG GLU A 372 37.707 −11.451 12.961 1.00 22.59 A C ATOM 5923 CD GLU A 372 39.205 −11.722 12.862 1.00 26.48 A C ATOM 5924 OE1 GLU A 372 39.992 −10.748 12.800 1.00 29.10 A O ATOM 5925 OE2 GLU A 372 39.594 −12.912 12.843 1.00 27.20 A O ATOM 5926 C GLU A 372 35.854 −8.752 14.976 1.00 18.32 A C ATOM 5927 O GLU A 372 35.775 −9.040 16.171 1.00 18.34 A O ATOM 5929 N ALA A 373 35.886 −7.497 14.528 1.00 17.77 A N ATOM 5930 CA ALA A 373 35.846 −6.347 15.429 1.00 17.52 A C ATOM 5932 CB ALA A 373 36.239 −5.085 14.685 1.00 17.47 A C ATOM 5936 C ALA A 373 34.472 −6.171 16.083 1.00 17.59 A C ATOM 5937 O ALA A 373 34.383 −5.819 17.259 1.00 17.52 A O ATOM 5939 N LYS A 374 33.408 −6.416 15.319 1.00 17.66 A N ATOM 5940 CA LYS A 374 32.037 −6.287 15.827 1.00 17.69 A C ATOM 5942 CB LYS A 374 31.016 −6.485 14.700 1.00 17.73 A C ATOM 5945 CG LYS A 374 30.781 −5.244 13.848 1.00 18.61 A C ATOM 5948 CD LYS A 374 29.872 −5.544 12.659 1.00 19.44 A C ATOM 5951 CE LYS A 374 29.505 −4.277 11.898 1.00 18.81 A C ATOM 5954 NZ LYS A 374 28.710 −4.565 10.673 1.00 18.02 A N ATOM 5958 C LYS A 374 31.735 −7.250 16.977 1.00 17.82 A C ATOM 5959 O LYS A 374 31.028 −6.884 17.917 1.00 17.93 A O ATOM 5961 N TRP A 375 32.260 −8.473 16.896 1.00 18.05 A N ATOM 5962 CA TRP A 375 32.132 −9.445 17.989 1.00 18.34 A C ATOM 5964 CB TRP A 375 32.660 −10.824 17.575 1.00 18.28 A C ATOM 5967 CG TRP A 375 31.847 −11.529 16.523 1.00 18.45 A C ATOM 5968 CD1 TRP A 375 30.498 −11.446 16.328 1.00 19.67 A C ATOM 5970 NE1 TRP A 375 30.119 −12.249 15.278 1.00 18.96 A N ATOM 5972 CE2 TRP A 375 31.228 −12.882 14.782 1.00 17.60 A C ATOM 5973 CD2 TRP A 375 32.336 −12.457 15.545 1.00 17.42 A C ATOM 5974 CE3 TRP A 375 33.604 −12.962 15.235 1.00 17.04 A C ATOM 5976 CZ3 TRP A 375 33.724 −13.861 14.186 1.00 17.20 A C ATOM 5978 CH2 TRP A 375 32.602 −14.267 13.446 1.00 17.60 A C ATOM 5980 CZ2 TRP A 375 31.350 −13.790 13.728 1.00 17.78 A C ATOM 5982 C TRP A 375 32.883 −8.983 19.241 1.00 18.75 A C ATOM 5983 O TRP A 375 32.402 −9.171 20.362 1.00 19.03 A O ATOM 5985 N LEU A 376 34.062 −8.392 19.041 1.00 18.64 A N ATOM 5986 CA LEU A 376 34.890 −7.907 20.147 1.00 18.48 A C ATOM 5988 CB LEU A 376 36.302 −7.572 19.650 1.00 18.65 A C ATOM 5991 CG LEU A 376 37.413 −7.399 20.697 1.00 20.28 A C ATOM 5993 CD1 LEU A 376 38.775 −7.749 20.098 1.00 21.89 A C ATOM 5997 CD2 LEU A 376 37.437 −5.986 21.285 1.00 20.91 A C ATOM 6001 C LEU A 376 34.257 −6.693 20.834 1.00 18.28 A C ATOM 6002 O LEU A 376 34.401 −6.525 22.046 1.00 18.58 A O ATOM 6004 N TYR A 377 33.559 −5.857 20.065 1.00 17.92 A N ATOM 6005 CA TYR A 377 32.851 −4.698 20.622 1.00 17.91 A C ATOM 6007 CB TYR A 377 32.456 −3.710 19.513 1.00 18.04 A C ATOM 6010 CG TYR A 377 31.758 −2.460 20.019 1.00 18.20 A C ATOM 6011 CD1 TYR A 377 32.450 −1.505 20.762 1.00 19.47 A C ATOM 6013 CE1 TYR A 377 31.817 −0.357 21.234 1.00 19.90 A C ATOM 6015 CZ TYR A 377 30.474 −0.154 20.961 1.00 20.89 A C ATOM 6016 OH TYR A 377 29.846 0.980 21.429 1.00 19.22 A O ATOM 6018 CE2 TYR A 377 29.763 −1.090 20.223 1.00 20.13 A C ATOM 6020 CD2 TYR A 377 30.409 −2.234 19.756 1.00 18.66 A C ATOM 6022 C TYR A 377 31.607 −5.126 21.408 1.00 17.54 A C ATOM 6023 O TYR A 377 31.403 −4.696 22.546 1.00 17.43 A O ATOM 6025 N ASN A 378 30.792 −5.984 20.797 1.00 17.04 A N ATOM 6026 CA ASN A 378 29.527 −6.421 21.392 1.00 16.71 A C ATOM 6028 CB ASN A 378 28.534 −6.789 20.287 1.00 16.56 A C ATOM 6031 CG ASN A 378 28.283 −5.644 19.323 1.00 16.15 A C ATOM 6032 OD1 ASN A 378 27.985 −4.526 19.735 1.00 15.51 A O ATOM 6033 ND2 ASN A 378 28.405 −5.920 18.031 1.00 16.34 A N ATOM 6036 C ASN A 378 29.675 −7.599 22.356 1.00 16.69 A C ATOM 6037 O ASN A 378 28.687 −8.058 22.932 1.00 16.54 A O ATOM 6039 N LYS A 379 30.905 −8.083 22.528 1.00 16.67 A N ATOM 6040 CA LYS A 379 31.188 −9.241 23.375 1.00 16.55 A C ATOM 6042 CB LYS A 379 31.047 −8.874 24.859 1.00 16.40 A C ATOM 6045 CG LYS A 379 32.158 −7.964 25.348 1.00 17.12 A C ATOM 6048 CD LYS A 379 31.853 −7.352 26.702 1.00 17.89 A C ATOM 6051 CE LYS A 379 33.029 −6.523 27.198 1.00 18.11 A C ATOM 6054 NZ LYS A 379 32.604 −5.464 28.151 1.00 19.23 A N ATOM 6058 C LYS A 379 30.305 −10.432 22.997 1.00 16.36 A C ATOM 6059 O LYS A 379 29.725 −11.093 23.859 1.00 17.03 A O ATOM 6061 N SER A 380 30.214 −10.691 21.695 1.00 15.82 A N ATOM 6062 CA SER A 380 29.447 −11.818 21.179 1.00 15.44 A C ATOM 6064 CB SER A 380 29.261 −11.686 19.667 1.00 15.30 A C ATOM 6067 OG SER A 380 28.738 −10.414 19.326 1.00 14.16 A O ATOM 6069 C SER A 380 30.171 −13.118 21.503 1.00 15.54 A C ATOM 6070 O SER A 380 31.377 −13.115 21.747 1.00 15.63 A O ATOM 6072 N THR A 381 29.433 −14.226 21.504 1.00 15.71 A N ATOM 6073 CA THR A 381 30.004 −15.538 21.812 1.00 16.14 A C ATOM 6075 CB THR A 381 29.483 −16.076 23.173 1.00 16.44 A C ATOM 6077 OG1 THR A 381 28.057 −16.215 23.133 1.00 17.09 A O ATOM 6079 CG2 THR A 381 29.863 −15.133 24.309 1.00 17.19 A C ATOM 6083 C THR A 381 29.694 −16.539 20.696 1.00 16.10 A C ATOM 6084 O THR A 381 29.099 −17.591 20.947 1.00 16.34 A O ATOM 6086 N PRO A 382 30.115 −16.223 19.456 1.00 16.07 A N ATOM 6087 CA PRO A 382 29.789 −17.060 18.297 1.00 16.17 A C ATOM 6089 CB PRO A 382 30.430 −16.303 17.131 1.00 16.16 A C ATOM 6092 CG PRO A 382 31.535 −15.532 17.747 1.00 15.98 A C ATOM 6095 CD PRO A 382 31.022 −15.120 19.086 1.00 16.01 A C ATOM 6098 C PRO A 382 30.369 −18.470 18.385 1.00 16.25 A C ATOM 6099 O PRO A 382 31.442 −18.665 18.963 1.00 16.33 A O ATOM 6100 N THR A 383 29.662 −19.439 17.807 1.00 16.20 A N ATOM 6101 CA THR A 383 30.120 −20.828 17.800 1.00 15.92 A C ATOM 6103 CB THR A 383 29.044 −21.794 17.251 1.00 15.85 A C ATOM 6105 OG1 THR A 383 28.676 −21.409 15.920 1.00 14.24 A O ATOM 6107 CG2 THR A 383 27.807 −21.793 18.147 1.00 15.69 A C ATOM 6111 C THR A 383 31.387 −20.962 16.964 1.00 15.82 A C ATOM 6112 O THR A 383 31.668 −20.120 16.111 1.00 15.84 A O ATOM 6114 N PHE A 384 32.148 −22.021 17.219 1.00 15.86 A N ATOM 6115 CA PHE A 384 33.401 −22.274 16.508 1.00 15.78 A C ATOM 6117 CB PHE A 384 33.909 −23.687 16.812 1.00 15.96 A C ATOM 6120 CG PHE A 384 35.097 −24.097 15.987 1.00 15.25 A C ATOM 6121 CD1 PHE A 384 36.337 −23.510 16.195 1.00 15.45 A C ATOM 6123 CE1 PHE A 384 37.439 −23.887 15.438 1.00 15.15 A C ATOM 6125 CZ PHE A 384 37.305 −24.858 14.464 1.00 14.65 A C ATOM 6127 CE2 PHE A 384 36.072 −25.450 14.247 1.00 14.59 A C ATOM 6129 CD2 PHE A 384 34.977 −25.070 15.007 1.00 14.05 A C ATOM 6131 C PHE A 384 33.251 −22.101 15.002 1.00 15.75 A C ATOM 6132 O PHE A 384 34.061 −21.426 14.371 1.00 15.67 A O ATOM 6134 N ASP A 385 32.206 −22.704 14.439 1.00 15.83 A N ATOM 6135 CA ASP A 385 31.997 −22.699 12.990 1.00 15.78 A C ATOM 6137 CB ASP A 385 30.956 −23.755 12.593 1.00 15.57 A C ATOM 6140 CG ASP A 385 31.473 −25.179 12.750 1.00 14.28 A C ATOM 6141 OD1 ASP A 385 32.696 −25.397 12.644 1.00 14.47 A O ATOM 6142 OD2 ASP A 385 30.656 −26.092 12.971 1.00 13.30 A O ATOM 6143 C ASP A 385 31.618 −21.329 12.420 1.00 16.22 A C ATOM 6144 O ASP A 385 31.727 −21.121 11.215 1.00 16.29 A O ATOM 6146 N ASP A 386 31.178 −20.403 13.272 1.00 17.06 A N ATOM 6147 CA ASP A 386 30.967 −19.011 12.854 1.00 18.04 A C ATOM 6149 CB ASP A 386 29.900 −18.310 13.711 1.00 18.36 A C ATOM 6152 CG ASP A 386 28.490 −18.461 13.146 1.00 19.49 A C ATOM 6153 OD1 ASP A 386 28.242 −19.410 12.369 1.00 21.38 A O ATOM 6154 OD2 ASP A 386 27.625 −17.625 13.489 1.00 18.48 A O ATOM 6155 C ASP A 386 32.271 −18.223 12.910 1.00 18.63 A C ATOM 6156 O ASP A 386 32.644 −17.582 11.930 1.00 19.56 A O ATOM 6158 N TYR A 387 32.962 −18.265 14.048 1.00 19.03 A N ATOM 6159 CA TYR A 387 34.237 −17.556 14.182 1.00 19.44 A C ATOM 6161 CB TYR A 387 34.793 −17.629 15.614 1.00 19.51 A C ATOM 6164 CG TYR A 387 36.142 −16.950 15.762 1.00 21.18 A C ATOM 6165 CD1 TYR A 387 36.235 −15.576 15.975 1.00 22.72 A C ATOM 6167 CE1 TYR A 387 37.476 −14.945 16.095 1.00 24.66 A C ATOM 6169 CZ TYR A 387 38.641 −15.695 15.996 1.00 25.02 A C ATOM 6170 OH TYR A 387 39.870 −15.084 16.116 1.00 24.90 A O ATOM 6172 CE2 TYR A 387 38.573 −17.060 15.778 1.00 24.35 A C ATOM 6174 CD2 TYR A 387 37.328 −17.680 15.661 1.00 23.39 A C ATOM 6176 C TYR A 387 35.273 −18.089 13.188 1.00 19.48 A C ATOM 6177 O TYR A 387 35.892 −17.311 12.462 1.00 19.69 A O ATOM 6179 N PHE A 388 35.451 −19.409 13.155 1.00 19.44 A N ATOM 6180 CA PHE A 388 36.464 −20.016 12.293 1.00 19.32 A C ATOM 6182 CB PHE A 388 36.682 −21.490 12.626 1.00 19.39 A C ATOM 6185 CG PHE A 388 37.829 −22.101 11.878 1.00 19.88 A C ATOM 6186 CD1 PHE A 388 39.135 −21.824 12.251 1.00 19.14 A C ATOM 6188 CE1 PHE A 388 40.201 −22.370 11.559 1.00 20.10 A C ATOM 6190 CZ PHE A 388 39.969 −23.199 10.470 1.00 20.36 A C ATOM 6192 CE2 PHE A 388 38.669 −23.476 10.080 1.00 20.47 A C ATOM 6194 CD2 PHE A 388 37.606 −22.924 10.780 1.00 20.61 A C ATOM 6196 C PHE A 388 36.131 −19.869 10.813 1.00 19.22 A C ATOM 6197 O PHE A 388 37.028 −19.679 9.995 1.00 19.09 A O ATOM 6199 N GLY A 389 34.851 −19.963 10.468 1.00 19.30 A N ATOM 6200 CA GLY A 389 34.411 −19.671 9.106 1.00 19.45 A C ATOM 6203 C GLY A 389 34.924 −18.310 8.665 1.00 19.46 A C ATOM 6204 O GLY A 389 35.561 −18.186 7.616 1.00 19.53 A O ATOM 6206 N ASN A 390 34.662 −17.297 9.491 1.00 19.12 A N ATOM 6207 CA ASN A 390 35.119 −15.931 9.238 1.00 18.83 A C ATOM 6209 CB ASN A 390 34.388 −14.955 10.163 1.00 18.64 A C ATOM 6212 CG ASN A 390 34.691 −13.505 9.836 1.00 18.88 A C ATOM 6213 OD1 ASN A 390 34.151 −12.949 8.882 1.00 20.54 A O ATOM 6214 ND2 ASN A 390 35.561 −12.887 10.627 1.00 17.01 A N ATOM 6217 C ASN A 390 36.630 −15.750 9.416 1.00 18.88 A C ATOM 6218 O ASN A 390 37.240 −14.918 8.742 1.00 19.57 A O ATOM 6220 N ALA A 391 37.225 −16.525 10.322 1.00 18.39 A N ATOM 6221 CA ALA A 391 38.636 −16.365 10.688 1.00 17.65 A C ATOM 6223 CB ALA A 391 38.977 −17.237 11.885 1.00 17.64 A C ATOM 6227 C ALA A 391 39.617 −16.635 9.547 1.00 17.17 A C ATOM 6228 O ALA A 391 40.541 −15.849 9.349 1.00 17.37 A O ATOM 6230 N TRP A 392 39.435 −17.727 8.801 1.00 16.59 A N ATOM 6231 CA TRP A 392 40.381 −18.048 7.718 1.00 16.35 A C ATOM 6233 CB TRP A 392 40.325 −19.525 7.281 1.00 16.37 A C ATOM 6236 CG TRP A 392 39.029 −20.021 6.712 1.00 17.82 A C ATOM 6237 CD1 TRP A 392 38.089 −20.760 7.363 1.00 20.80 A C ATOM 6239 NE1 TRP A 392 37.044 −21.053 6.522 1.00 21.26 A N ATOM 6241 CE2 TRP A 392 37.303 −20.516 5.290 1.00 19.01 A C ATOM 6242 CD2 TRP A 392 38.552 −19.864 5.369 1.00 18.29 A C ATOM 6243 CE3 TRP A 392 39.050 −19.225 4.229 1.00 18.54 A C ATOM 6245 CZ3 TRP A 392 38.297 −19.258 3.066 1.00 18.44 A C ATOM 6247 CH2 TRP A 392 37.060 −19.914 3.021 1.00 18.84 A C ATOM 6249 CZ2 TRP A 392 36.547 −20.547 4.120 1.00 18.75 A C ATOM 6251 C TRP A 392 40.272 −17.093 6.521 1.00 15.96 A C ATOM 6252 O TRP A 392 41.223 −16.957 5.754 1.00 15.58 A O ATOM 6254 N LYS A 393 39.131 −16.427 6.367 1.00 16.07 A N ATOM 6255 CA LYS A 393 39.018 −15.339 5.389 1.00 16.20 A C ATOM 6257 CB LYS A 393 37.556 −15.051 5.034 1.00 16.58 A C ATOM 6260 CG LYS A 393 36.893 −16.149 4.211 1.00 18.39 A C ATOM 6263 CD LYS A 393 35.609 −15.652 3.561 1.00 21.72 A C ATOM 6266 CE LYS A 393 34.704 −16.803 3.139 1.00 22.15 A C ATOM 6269 NZ LYS A 393 34.074 −17.470 4.313 1.00 22.61 A N ATOM 6273 C LYS A 393 39.699 −14.068 5.902 1.00 15.28 A C ATOM 6274 O LYS A 393 40.191 −13.264 5.108 1.00 15.25 A O ATOM 6276 N SER A 394 39.725 −13.891 7.223 1.00 14.19 A N ATOM 6277 CA SER A 394 40.438 −12.768 7.836 1.00 13.88 A C ATOM 6279 CB SER A 394 39.829 −12.405 9.194 1.00 13.76 A C ATOM 6282 OG SER A 394 40.198 −13.331 10.198 1.00 14.47 A O ATOM 6284 C SER A 394 41.938 −13.043 7.987 1.00 13.51 A C ATOM 6285 O SER A 394 42.696 −12.149 8.359 1.00 13.98 A O ATOM 6287 N SER A 395 42.363 −14.275 7.711 1.00 12.98 A N ATOM 6288 CA SER A 395 43.789 −14.608 7.665 1.00 12.09 A C ATOM 6290 CB SER A 395 43.987 −16.115 7.484 1.00 11.72 A C ATOM 6293 OG SER A 395 43.677 −16.517 6.160 1.00 9.17 A O ATOM 6295 C SER A 395 44.479 −13.873 6.520 1.00 11.88 A C ATOM 6296 O SER A 395 45.653 −13.530 6.620 1.00 12.00 A O ATOM 6298 N SER A 396 43.721 −13.637 5.446 1.00 11.56 A N ATOM 6299 CA SER A 396 44.212 −13.063 4.189 1.00 11.42 A C ATOM 6301 CB SER A 396 45.143 −11.858 4.416 1.00 11.41 A C ATOM 6304 OG SER A 396 46.494 −12.252 4.580 1.00 10.83 A O ATOM 6306 C SER A 396 44.887 −14.131 3.325 1.00 11.35 A C ATOM 6307 O SER A 396 45.498 −13.814 2.300 1.00 11.18 A O ATOM 6309 N GLY A 397 44.761 −15.392 3.740 1.00 11.18 A N ATOM 6310 CA GLY A 397 45.257 −16.523 2.966 1.00 11.19 A C ATOM 6313 C GLY A 397 44.591 −16.607 1.605 1.00 11.20 A C ATOM 6314 O GLY A 397 45.270 −16.806 0.596 1.00 11.77 A O ATOM 6316 N PRO A 398 43.254 −16.458 1.565 1.00 10.58 A N ATOM 6317 CA PRO A 398 42.574 −16.415 0.279 1.00 10.32 A C ATOM 6319 CB PRO A 398 41.095 −16.282 0.665 1.00 10.50 A C ATOM 6322 CG PRO A 398 41.013 −16.848 2.032 1.00 10.24 A C ATOM 6325 CD PRO A 398 42.295 −16.448 2.683 1.00 10.64 A C ATOM 6328 C PRO A 398 43.024 −15.235 −0.571 1.00 9.73 A C ATOM 6329 O PRO A 398 43.301 −15.405 −1.755 1.00 9.10 A O ATOM 6330 N LEU A 399 43.113 −14.054 0.030 1.00 9.90 A N ATOM 6331 CA LEU A 399 43.532 −12.871 −0.712 1.00 10.55 A C ATOM 6333 CB LEU A 399 43.538 −11.626 0.179 1.00 10.41 A C ATOM 6336 CG LEU A 399 43.677 −10.296 −0.568 1.00 9.15 A C ATOM 6338 CD1 LEU A 399 43.004 −9.192 0.209 1.00 10.37 A C ATOM 6342 CD2 LEU A 399 45.134 −9.947 −0.838 1.00 8.74 A C ATOM 6346 C LEU A 399 44.911 −13.095 −1.322 1.00 11.44 A C ATOM 6347 O LEU A 399 45.102 −12.893 −2.520 1.00 12.07 A O ATOM 6349 N GLN A 400 45.861 −13.534 −0.500 1.00 11.78 A N ATOM 6350 CA GLN A 400 47.230 −13.779 −0.966 1.00 12.03 A C ATOM 6352 CB GLN A 400 48.106 −14.301 0.176 1.00 12.44 A C ATOM 6355 CG GLN A 400 48.616 −13.216 1.117 1.00 12.64 A C ATOM 6358 CD GLN A 400 49.595 −13.754 2.141 1.00 11.76 A C ATOM 6359 OE1 GLN A 400 50.554 −14.442 1.799 1.00 11.16 A O ATOM 6360 NE2 GLN A 400 49.353 −13.447 3.407 1.00 12.59 A N ATOM 6363 C GLN A 400 47.308 −14.742 −2.155 1.00 11.86 A C ATOM 6364 O GLN A 400 48.147 −14.574 −3.038 1.00 11.52 A O ATOM 6366 N LEU A 401 46.443 −15.750 −2.176 1.00 12.22 A N ATOM 6367 CA LEU A 401 46.442 −16.721 −3.269 1.00 12.76 A C ATOM 6369 CB LEU A 401 45.926 −18.087 −2.791 1.00 12.53 A C ATOM 6372 CG LEU A 401 46.818 −18.811 −1.772 1.00 11.90 A C ATOM 6374 CD1 LEU A 401 46.158 −20.09 −1.294 1.00 13.20 A C ATOM 6378 CD2 LEU A 401 48.195 −19.11 −2.346 1.00 9.64 A C ATOM 6382 C LEU A 401 45.649 −16.225 −4.485 1.00 13.27 A C ATOM 6383 O LEU A 401 45.910 −16.662 −5.609 1.00 13.80 A O ATOM 6385 N VAL A 402 44.693 −15.320 −4.272 1.00 13.43 A N ATOM 6386 CA VAL A 402 43.968 −14.700 −5.391 1.00 13.52 A C ATOM 6388 CB VAL A 402 42.791 −13.811 −4.915 1.00 13.58 A C ATOM 6390 CG1 VAL A 402 41.759 −14.647 −4.186 1.00 14.22 A C ATOM 6394 CG2 VAL A 402 42.146 −13.090 −6.093 1.00 11.75 A C ATOM 6398 C VAL A 402 44.924 −13.864 −6.244 1.00 13.38 A C ATOM 6399 O VAL A 402 44.798 −13.827 −7.463 1.00 13.04 A O ATOM 6401 N PHE A 403 45.880 −13.207 −5.594 1.00 13.34 A N ATOM 6402 CA PHE A 403 46.916 −12.455 −6.301 1.00 13.95 A C ATOM 6404 CB PHE A 403 47.544 −11.410 −5.376 1.00 14.44 A C ATOM 6407 CG PHE A 403 46.673 −10.206 −5.155 1.00 14.69 A C ATOM 6408 CD1 PHE A 403 46.949 −9.004 −5.795 1.00 13.14 A C ATOM 6410 CE1 PHE A 403 46.140 −7.903 −5.598 1.00 13.57 A C ATOM 6412 CZ PHE A 403 45.035 −7.999 −4.763 1.00 14.00 A C ATOM 6414 CE2 PHE A 403 44.749 −9.191 −4.128 1.00 12.73 A C ATOM 6416 CD2 PHE A 403 45.560 −10.285 −4.328 1.00 12.55 A C ATOM 6418 C PHE A 403 47.991 −13.378 −6.867 1.00 13.90 A C ATOM 6419 O PHE A 403 48.496 −13.154 −7.971 1.00 13.60 A O ATOM 6421 N ALA A 404 48.335 −14.411 −6.101 1.00 14.11 A N ATOM 6422 CA ALA A 404 49.301 −15.419 −6.533 1.00 14.01 A C ATOM 6424 CB ALA A 404 49.536 −16.439 −5.420 1.00 14.07 A C ATOM 6428 C ALA A 404 48.850 −16.123 −7.813 1.00 13.46 A C ATOM 6429 O ALA A 404 49.676 −16.483 −8.651 1.00 13.31 A O ATOM 6431 N TYR A 405 47.542 −16.315 −7.960 1.00 13.06 A N ATOM 6432 CA TYR A 405 46.990 −16.912 −9.172 1.00 13.33 A C ATOM 6434 CB TYR A 405 45.458 −16.967 −9.110 1.00 12.98 A C ATOM 6437 CG TYR A 405 44.842 −17.457 −10.398 1.00 11.28 A C ATOM 6438 CD1 TYR A 405 44.849 −18.808 −10.721 1.00 11.80 A C ATOM 6440 CE1 TYR A 405 44.297 −19.269 −11.914 1.00 11.52 A C ATOM 6442 CZ TYR A 405 43.741 −18.369 −12.801 1.00 10.95 A C ATOM 6443 OH TYR A 405 43.199 −18.819 −13.980 1.00 9.66 A O ATOM 6445 CE2 TYR A 405 43.729 −17.016 −12.505 1.00 11.40 A C ATOM 6447 CD2 TYR A 405 44.280 −16.568 −11.308 1.00 10.90 A C ATOM 6449 C TYR A 405 47.424 −16.133 −10.411 1.00 14.22 A C ATOM 6450 O TYR A 405 47.961 −16.709 −11.360 1.00 14.09 A O ATOM 6452 N PHE A 406 47.198 −14.820 −10.384 1.00 15.24 A N ATOM 6453 CA PHE A 406 47.442 −13.958 −11.546 1.00 15.22 A C ATOM 6455 CB PHE A 406 46.733 −12.613 −11.377 1.00 14.88 A C ATOM 6458 CG PHE A 406 45.237 −12.722 −11.317 1.00 13.53 A C ATOM 6459 CD1 PHE A 406 44.504 −13.009 −12.458 1.00 13.38 A C ATOM 6461 CE1 PHE A 406 43.126 −13.107 −12.408 1.00 12.53 A C ATOM 6463 CZ PHE A 406 42.465 −12.913 −11.210 1.00 12.19 A C ATOM 6465 CE2 PHE A 406 43.186 −12.623 −10.068 1.00 11.97 A C ATOM 6467 CD2 PHE A 406 44.563 −12.528 −10.126 1.00 11.83 A C ATOM 6469 C PHE A 406 48.922 −13.717 −11.831 1.00 15.89 A C ATOM 6470 O PHE A 406 49.267 −13.239 −12.912 1.00 16.18 A O ATOM 6472 N ALA A 407 49.789 −14.025 −10.868 1.00 16.30 A N ATOM 6473 CA ALA A 407 51.230 −13.919 −11.078 1.00 16.47 A C ATOM 6475 CB ALA A 407 51.945 −13.724 −9.764 1.00 16.54 A C ATOM 6479 C ALA A 407 51.764 −15.156 −11.785 1.00 17.01 A C ATOM 6480 O ALA A 407 52.403 −15.039 −12.828 1.00 17.63 A O ATOM 6482 N VAL A 408 51.479 −16.333 −11.227 1.00 17.52 A N ATOM 6483 CA VAL A 408 52.125 −17.582 −11.661 1.00 18.18 A C ATOM 6485 CB VAL A 408 52.196 −18.620 −10.509 1.00 18.02 A C ATOM 6487 CG1 VAL A 408 52.962 −18.048 −9.323 1.00 17.51 A C ATOM 6491 CG2 VAL A 408 50.808 −19.070 −10.091 1.00 17.56 A C ATOM 6495 C VAL A 408 51.510 −18.259 −12.896 1.00 19.13 A C ATOM 6496 O VAL A 408 52.226 −18.899 −13.665 1.00 19.26 A O ATOM 6498 N VAL A 409 50.201 −18.127 −13.088 1.00 20.36 A N ATOM 6499 CA VAL A 409 49.523 −18.799 −14.203 1.00 21.49 A C ATOM 6501 CB VAL A 409 48.010 −18.951 −13.934 1.00 21.39 A C ATOM 6503 CG1 VAL A 409 47.353 −19.765 −15.036 1.00 22.15 A C ATOM 6507 CG2 VAL A 409 47.771 −19.611 −12.584 1.00 22.07 A C ATOM 6511 C VAL A 409 49.722 −18.038 −15.521 1.00 22.53 A C ATOM 6512 O VAL A 409 49.629 −16.808 −15.547 1.00 23.27 A O ATOM 6514 N GLN A 410 49.994 −18.768 −16.607 1.00 23.04 A N ATOM 6515 CA GLN A 410 50.117 −18.159 −17.940 1.00 23.44 A C ATOM 6517 CB GLN A 410 50.609 −19.176 −18.988 1.00 23.94 A C ATOM 6520 CG GLN A 410 52.109 −19.114 −19.307 1.00 25.78 A C ATOM 6523 CD GLN A 410 52.465 −19.825 −20.619 1.00 27.06 A C ATOM 6524 OE1 GLN A 410 52.543 −21.055 −20.676 1.00 27.24 A O ATOM 6525 NE2 GLN A 410 52.688 −19.047 −21.675 1.00 25.76 A N ATOM 6528 C GLN A 410 48.782 −17.546 −18.378 1.00 23.54 A C ATOM 6529 O GLN A 410 48.589 −16.335 −18.271 1.00 23.64 A O ATOM 6531 N ASN A 411 47.864 −18.385 −18.853 1.00 23.79 A N ATOM 6532 CA ASN A 411 46.560 −17.921 −19.321 1.00 23.91 A C ATOM 6534 CB ASN A 411 46.095 −18.734 −20.535 1.00 24.06 A C ATOM 6537 CG ASN A 411 46.913 −18.446 −21.784 1.00 24.54 A C ATOM 6538 OD1 ASN A 411 46.413 −17.859 −22.745 1.00 23.89 A O ATOM 6539 ND2 ASN A 411 48.178 −18.858 −21.775 1.00 24.71 A N ATOM 6542 C ASN A 411 45.514 −18.009 −18.219 1.00 23.88 A C ATOM 6543 O ASN A 411 45.574 −18.888 −17.361 1.00 23.42 A O ATOM 6545 N ILE A 412 44.547 −17.098 −18.267 1.00 24.33 A N ATOM 6546 CA ILE A 412 43.466 −17.042 −17.285 1.00 24.54 A C ATOM 6548 CB ILE A 412 43.018 −15.583 −17.036 1.00 24.66 A C ATOM 6550 CG1 ILE A 412 44.224 −14.686 −16.727 1.00 24.61 A C ATOM 6553 CD1 ILE A 412 45.133 −15.218 −15.646 1.00 24.33 A C ATOM 6557 CG2 ILE A 412 41.997 −15.516 −15.910 1.00 25.28 A C ATOM 6561 C ILE A 412 42.267 −17.841 −17.788 1.00 24.52 A C ATOM 6562 O ILE A 412 41.795 −17.612 −18.901 1.00 24.75 A O ATOM 6564 N LYS A 413 41.776 −18.771 −16.973 1.00 24.56 A N ATOM 6565 CA LYS A 413 40.589 −19.552 −17.323 1.00 24.82 A C ATOM 6567 CB LYS A 413 40.819 −21.041 −17.055 1.00 25.06 A C ATOM 6570 CG LYS A 413 42.016 −21.623 −17.795 1.00 25.64 A C ATOM 6573 CD LYS A 413 41.849 −23.112 −18.064 1.00 28.37 A C ATOM 6576 CE LYS A 413 42.855 −23.606 −19.100 1.00 30.53 A C ATOM 6579 NZ LYS A 413 42.618 −25.028 −19.493 1.00 30.83 A N ATOM 6583 C LYS A 413 39.389 −19.053 −16.530 1.00 24.68 A C ATOM 6584 O LYS A 413 39.521 −18.714 −15.352 1.00 23.95 A O ATOM 6586 N LYS A 414 38.225 −19.005 −17.176 1.00 25.21 A N ATOM 6587 CA LYS A 414 37.006 −18.530 −16.517 1.00 25.78 A C ATOM 6589 CB LYS A 414 35.845 −18.387 −17.509 1.00 25.92 A C ATOM 6592 CG LYS A 414 34.681 −17.556 −16.956 1.00 27.75 A C ATOM 6595 CD LYS A 414 33.572 −17.312 −17.982 1.00 28.34 A C ATOM 6598 CE LYS A 414 32.817 −18.588 −18.334 1.00 28.85 A C ATOM 6601 NZ LYS A 414 32.295 −19.301 −17.133 1.00 28.73 A N ATOM 6605 C LYS A 414 36.612 −19.462 −15.371 1.00 25.94 A C ATOM 6606 O LYS A 414 36.215 −18.997 −14.301 1.00 26.04 A O ATOM 6608 N GLU A 415 36.734 −20.771 −15.598 1.00 25.93 A N ATOM 6609 CA GLU A 415 36.443 −21.772 −14.567 1.00 25.59 A C ATOM 6611 CB GLU A 415 36.571 −23.194 −15.129 1.00 25.91 A C ATOM 6614 CG GLU A 415 35.980 −24.278 −14.212 1.00 27.72 A C ATOM 6617 CD GLU A 415 36.785 −25.576 −14.192 1.00 29.56 A C ATOM 6618 OE1 GLU A 415 38.035 −25.519 −14.216 1.00 30.42 A O ATOM 6619 OE2 GLU A 415 36.160 −26.658 −14.127 1.00 30.95 A O ATOM 6620 C GLU A 415 37.375 −21.614 −13.367 1.00 24.71 A C ATOM 6621 O GLU A 415 36.925 −21.641 −12.221 1.00 24.35 A O ATOM 6623 N GLU A 416 38.668 −21.455 −13.635 1.00 24.19 A N ATOM 6624 CA GLU A 416 39.653 −21.259 −12.574 1.00 24.24 A C ATOM 6626 CB GLU A 416 41.062 −21.074 −13.151 1.00 24.41 A C ATOM 6629 CG GLU A 416 41.712 −22.376 −13.612 1.00 25.81 A C ATOM 6632 CD GLU A 416 43.177 −22.214 −13.985 1.00 26.72 A C ATOM 6633 OE1 GLU A 416 43.547 −21.142 −14.507 1.00 27.38 A O ATOM 6634 OE2 GLU A 416 43.958 −23.166 −13.764 1.00 26.58 A O ATOM 6635 C GLU A 416 39.291 −20.077 −11.673 1.00 23.98 A C ATOM 6636 O GLU A 416 39.215 −20.232 −10.454 1.00 23.87 A O ATOM 6638 N ILE A 417 39.052 −18.910 −12.269 1.00 23.83 A N ATOM 6639 CA ILE A 417 38.704 −17.719 −11.484 1.00 23.96 A C ATOM 6641 CB ILE A 417 38.800 −16.395 −12.301 1.00 24.26 A C ATOM 6643 CG1 ILE A 417 37.708 −16.310 −13.373 1.00 24.99 A C ATOM 6646 CD1 ILE A 417 37.647 −14.966 −14.065 1.00 24.44 A C ATOM 6650 CG2 ILE A 417 40.185 −16.249 −12.925 1.00 23.85 A C ATOM 6654 C ILE A 417 37.316 −17.828 −10.848 1.00 23.84 A C ATOM 6655 O ILE A 417 37.052 −17.190 −9.832 1.00 23.74 A O ATOM 6657 N GLU A 418 36.438 −18.631 −11.448 1.00 23.87 A N ATOM 6658 CA GLU A 418 35.107 −18.886 −10.882 1.00 24.02 A C ATOM 6660 CB GLU A 418 34.281 −19.798 −11.802 1.00 24.29 A C ATOM 6663 CG GLU A 418 32.821 −19.382 −11.980 1.00 25.56 A C ATOM 6666 CD GLU A 418 32.536 −18.833 −13.367 1.00 27.78 A C ATOM 6667 OE1 GLU A 418 32.836 −19.536 −14.358 1.00 29.63 A O ATOM 6668 OE2 GLU A 418 32.003 −17.707 −13.469 1.00 28.94 A O ATOM 6669 C GLU A 418 35.227 −19.551 −9.510 1.00 23.54 A C ATOM 6670 O GLU A 418 34.483 −19.225 −8.585 1.00 23.37 A O ATOM 6672 N ASN A 419 36.161 −20.494 −9.399 1.00 23.03 A N ATOM 6673 CA ASN A 419 36.414 −21.200 −8.144 1.00 22.72 A C ATOM 6675 CB ASN A 419 37.219 −22.481 −8.399 1.00 22.49 A C ATOM 6678 CG ASN A 419 36.353 −23.621 −8.901 1.00 21.26 A C ATOM 6679 OD1 ASN A 419 35.999 −24.523 −8.143 1.00 20.38 A O ATOM 6680 ND2 ASN A 419 35.994 −23.577 −10.176 1.00 18.71 A N ATOM 6683 C ASN A 419 37.110 −20.332 −7.094 1.00 22.76 A C ATOM 6684 O ASN A 419 36.831 −20.460 −5.901 1.00 22.68 A O ATOM 6686 N LEU A 420 38.007 −19.450 −7.535 1.00 23.02 A N ATOM 6687 CA LEU A 420 38.646 −18.485 −6.630 1.00 23.24 A C ATOM 6689 CB LEU A 420 39.740 −17.689 −7.352 1.00 23.12 A C ATOM 6692 CG LEU A 420 40.950 −18.465 −7.878 1.00 22.58 A C ATOM 6694 CD1 LEU A 420 41.884 −17.542 −8.649 1.00 23.76 A C ATOM 6698 CD2 LEU A 420 41.694 −19.150 −6.747 1.00 21.73 A C ATOM 6702 C LEU A 420 37.616 −17.519 −6.037 1.00 23.34 A C ATOM 6703 O LEU A 420 37.698 −17.159 −4.862 1.00 23.29 A O ATOM 6705 N GLN A 421 36.649 −17.113 −6.859 1.00 23.39 A N ATOM 6706 CA GLN A 421 35.555 −16.240 −6.426 1.00 23.61 A C ATOM 6708 CB GLN A 421 34.664 −15.883 −7.619 1.00 23.81 A C ATOM 6711 CG GLN A 421 35.317 −14.977 −8.655 1.00 25.57 A C ATOM 6714 CD GLN A 421 35.021 −13.508 −8.426 1.00 27.53 A C ATOM 6715 OE1 GLN A 421 34.355 −12.867 −9.241 1.00 27.80 A O ATOM 6716 NE2 GLN A 421 35.507 −12.967 −7.310 1.00 28.75 A N ATOM 6719 C GLN A 421 34.687 −16.871 −5.336 1.00 23.75 A C ATOM 6720 O GLN A 421 34.012 −16.160 −4.594 1.00 23.75 A O ATOM 6722 N LYS A 422 34.699 −18.202 −5.254 1.00 24.07 A N ATOM 6723 CA LYS A 422 33.875 −18.944 −4.301 1.00 24.27 A C ATOM 6725 CB LYS A 422 33.053 −19.995 −5.060 1.00 24.49 A C ATOM 6728 CG LYS A 422 32.059 −19.388 −6.053 1.00 26.08 A C ATOM 6731 CD LYS A 422 31.640 −20.375 −7.140 1.00 28.24 A C ATOM 6734 CE LYS A 422 30.776 −19.693 −8.205 1.00 28.90 A C ATOM 6737 NZ LYS A 422 30.279 −20.642 −9.246 1.00 28.82 A N ATOM 6741 C LYS A 422 34.716 −19.603 −3.196 1.00 23.98 A C ATOM 6742 O LYS A 422 34.248 −20.524 −2.519 1.00 23.87 A O ATOM 6744 N TYR A 423 35.942 −19.107 −3.005 1.00 23.57 A N ATOM 6745 CA TYR A 423 36.902 −19.675 −2.046 1.00 23.15 A C ATOM 6747 CB TYR A 423 36.697 −19.077 −0.643 1.00 22.87 A C ATOM 6750 CG TYR A 423 36.761 −17.559 −0.637 1.00 23.55 A C ATOM 6751 CD1 TYR A 423 37.857 −16.888 −1.182 1.00 24.97 A C ATOM 6753 CE1 TYR A 423 37.919 −15.497 −1.197 1.00 24.81 A C ATOM 6755 CZ TYR A 423 36.880 −14.761 −0.660 1.00 24.32 A C ATOM 6756 OH TYR A 423 36.945 −13.388 −0.673 1.00 23.63 A O ATOM 6758 CE2 TYR A 423 35.782 −15.400 −0.110 1.00 23.79 A C ATOM 6760 CD2 TYR A 423 35.726 −16.794 −0.102 1.00 24.22 A C ATOM 6762 C TYR A 423 36.847 −21.206 −2.046 1.00 22.87 A C ATOM 6763 O TYR A 423 36.540 −21.849 −1.038 1.00 23.25 A O ATOM 6765 N HIS A 424 37.144 −21.765 −3.214 1.00 22.22 A N ATOM 6766 CA HIS A 424 37.125 −23.205 −3.449 1.00 21.90 A C ATOM 6768 CB HIS A 424 37.276 −23.465 −4.956 1.00 22.14 A C ATOM 6771 CG HIS A 424 37.467 −24.904 −5.320 1.00 23.25 A C ATOM 6772 ND1 HIS A 424 38.681 −25.408 −5.734 1.00 23.32 A N ATOM 6774 CE1 HIS A 424 38.555 −26.698 −5.989 1.00 23.99 A C ATOM 6776 NE2 HIS A 424 37.303 −27.049 −5.758 1.00 24.51 A N ATOM 6778 CD2 HIS A 424 36.600 −25.944 −5.341 1.00 24.99 A C ATOM 6780 C HIS A 424 38.232 −23.894 −2.652 1.00 21.23 A C ATOM 6781 O HIS A 424 39.226 −23.266 −2.293 1.00 21.22 A O ATOM 6783 N ASP A 425 38.042 −25.184 −2.383 1.00 20.88 A N ATOM 6784 CA ASP A 425 38.963 −25.991 −1.561 1.00 20.94 A C ATOM 6786 CB ASP A 425 38.655 −27.491 −1.731 1.00 21.19 A C ATOM 6789 CG ASP A 425 37.337 −27.908 −1.083 1.00 22.84 A C ATOM 6790 OD1 ASP A 425 36.714 −27.086 −0.374 1.00 27.02 A O ATOM 6791 OD2 ASP A 425 36.923 −29.070 −1.284 1.00 23.18 A O ATOM 6792 C ASP A 425 40.467 −25.759 −1.800 1.00 20.30 A C ATOM 6793 O ASP A 425 41.253 −25.806 −0.851 1.00 20.33 A O ATOM 6795 N THR A 426 40.870 −25.519 −3.046 1.00 19.20 A N ATOM 6796 CA THR A 426 42.295 −25.401 −3.366 1.00 18.17 A C ATOM 6798 CB THR A 426 42.546 −25.212 −4.878 1.00 17.95 A C ATOM 6800 OG1 THR A 426 41.842 −26.219 −5.612 1.00 17.41 A O ATOM 6802 CG2 THR A 426 44.033 −25.315 −5.196 1.00 15.99 A C ATOM 6806 C THR A 426 42.960 −24.263 −2.597 1.00 17.94 A C ATOM 6807 O THR A 426 44.085 −24.424 −2.127 1.00 18.23 A O ATOM 6809 N ILE A 427 42.270 −23.127 −2.471 1.00 17.76 A N ATOM 6810 CA ILE A 427 42.795 −21.979 −1.711 1.00 17.88 A C ATOM 6812 CB ILE A 427 42.699 −20.642 −2.499 1.00 17.38 A C ATOM 6814 CG1 ILE A 427 41.246 −20.209 −2.701 1.00 16.70 A C ATOM 6817 CD1 ILE A 427 41.119 −18.858 −3.365 1.00 16.78 A C ATOM 6821 CG2 ILE A 427 43.415 −20.755 −3.836 1.00 16.09 A C ATOM 6825 C ILE A 427 42.137 −21.803 −0.339 1.00 18.62 A C ATOM 6826 O ILE A 427 42.602 −20.996 0.471 1.00 19.27 A O ATOM 6828 N SER A 428 41.065 −22.550 −0.082 1.00 18.85 A N ATOM 6829 CA SER A 428 40.426 −22.561 1.233 1.00 19.03 A C ATOM 6831 CB SER A 428 39.035 −23.200 1.145 1.00 18.90 A C ATOM 6834 OG SER A 428 38.499 −23.466 2.429 1.00 19.43 A O ATOM 6836 C SER A 428 41.291 −23.317 2.241 1.00 19.40 A C ATOM 6837 O SER A 428 41.671 −22.772 3.274 1.00 19.21 A O ATOM 6839 N ARG A 429 41.614 −24.566 1.914 1.00 20.31 A N ATOM 6840 CA ARG A 429 42.331 −25.465 2.833 1.00 20.92 A C ATOM 6842 CB ARG A 429 42.587 −26.839 2.185 1.00 21.25 A C ATOM 6845 CG ARG A 429 41.326 −27.586 1.733 1.00 23.47 A C ATOM 6848 CD ARG A 429 40.833 −28.594 2.762 1.00 26.54 A C ATOM 6851 NE ARG A 429 39.381 −28.778 2.710 1.00 28.25 A N ATOM 6853 CZ ARG A 429 38.719 −29.394 1.730 1.00 29.99 A C ATOM 6854 NH1 ARG A 429 39.359 −29.903 0.676 1.00 29.63 A N ATOM 6857 NH2 ARG A 429 37.396 −29.497 1.801 1.00 30.83 A N ATOM 6860 C ARG A 429 43.649 −24.871 3.347 1.00 20.52 A C ATOM 6861 O ARG A 429 43.869 −24.835 4.555 1.00 20.89 A O ATOM 6863 N PRO A 430 44.524 −24.388 2.442 1.00 19.92 A N ATOM 6864 CA PRO A 430 45.782 −23.822 2.933 1.00 19.69 A C ATOM 6866 CB PRO A 430 46.451 −23.278 1.664 1.00 19.80 A C ATOM 6869 CG PRO A 430 45.801 −23.986 0.541 1.00 19.77 A C ATOM 6872 CD PRO A 430 44.400 −24.245 0.982 1.00 20.08 A C ATOM 6875 C PRO A 430 45.558 −22.695 3.934 1.00 19.44 A C ATOM 6876 O PRO A 430 46.314 −22.573 4.898 1.00 19.69 A O ATOM 6877 N SER A 431 44.520 −21.891 3.701 1.00 19.05 A N ATOM 6878 CA SER A 431 44.171 −20.780 4.591 1.00 18.38 A C ATOM 6880 CB SER A 431 43.173 −19.843 3.910 1.00 18.34 A C ATOM 6883 OG SER A 431 43.653 −19.431 2.639 1.00 18.28 A O ATOM 6885 C SER A 431 43.610 −21.273 5.925 1.00 17.67 A C ATOM 6886 O SER A 431 43.797 −20.621 6.954 1.00 16.78 A O ATOM 6888 N HIS A 432 42.922 −22.417 5.896 1.00 17.38 A N ATOM 6889 CA HIS A 432 42.501 −23.105 7.121 1.00 17.22 A C ATOM 6891 CB HIS A 432 41.774 −24.426 6.803 1.00 17.35 A C ATOM 6894 CG HIS A 432 40.354 −24.255 6.353 1.00 16.88 A C ATOM 6895 ND1 HIS A 432 39.389 −25.215 6.569 1.00 16.42 A N ATOM 6897 CE1 HIS A 432 38.237 −24.799 6.074 1.00 16.45 A C ATOM 6899 NE2 HIS A 432 38.418 −23.601 5.548 1.00 14.80 A N ATOM 6901 CD2 HIS A 432 39.733 −23.236 5.712 1.00 16.06 A C ATOM 6903 C HIS A 432 43.723 −23.383 8.002 1.00 16.93 A C ATOM 6904 O HIS A 432 43.687 −23.163 9.215 1.00 16.68 A O ATOM 6906 N ILE A 433 44.800 −23.862 7.378 1.00 16.43 A N ATOM 6907 CA ILE A 433 46.064 −24.108 8.078 1.00 16.05 A C ATOM 6909 CB ILE A 433 47.080 −24.877 7.189 1.00 16.29 A C ATOM 6911 CG1 ILE A 433 46.752 −26.374 7.152 1.00 16.71 A C ATOM 6914 CD1 ILE A 433 45.604 −26.727 6.261 1.00 15.49 A C ATOM 6918 CG2 ILE A 433 48.505 −24.683 7.704 1.00 17.15 A C ATOM 6922 C ILE A 433 46.710 −22.804 8.553 1.00 15.22 A C ATOM 6923 O ILE A 433 47.267 −22.751 9.648 1.00 15.08 A O ATOM 6925 N PHE A 434 46.631 −21.765 7.725 1.00 14.47 A N ATOM 6926 CA PHE A 434 47.211 −20.455 8.034 1.00 14.05 A C ATOM 6928 CB PHE A 434 47.038 −19.527 6.814 1.00 13.92 A C ATOM 6931 CG PHE A 434 47.583 −18.117 6.985 1.00 13.80 A C ATOM 6932 CD1 PHE A 434 48.512 −17.785 7.967 1.00 14.68 A C ATOM 6934 CE1 PHE A 434 48.987 −16.482 8.081 1.00 13.77 A C ATOM 6936 CZ PHE A 434 48.558 −15.508 7.200 1.00 12.50 A C ATOM 6938 CE2 PHE A 434 47.654 −15.829 6.213 1.00 11.41 A C ATOM 6940 CD2 PHE A 434 47.177 −17.122 6.104 1.00 13.10 A C ATOM 6942 C PHE A 434 46.599 −19.864 9.311 1.00 13.97 A C ATOM 6943 O PHE A 434 47.325 −19.429 10.208 1.00 13.34 A O ATOM 6945 N ARG A 435 45.273 −19.878 9.407 1.00 14.22 A N ATOM 6946 CA ARG A 435 44.594 −19.371 10.603 1.00 14.37 A C ATOM 6948 CB ARG A 435 43.086 −19.241 10.359 1.00 14.35 A C ATOM 6951 CG ARG A 435 42.252 −18.907 11.593 1.00 15.10 A C ATOM 6954 CD ARG A 435 42.754 −17.675 12.337 1.00 16.05 A C ATOM 6957 NE ARG A 435 42.700 −16.464 11.524 1.00 17.00 A N ATOM 6959 CZ ARG A 435 43.235 −15.293 11.870 1.00 18.01 A C ATOM 6960 NH1 ARG A 435 43.888 −15.153 13.020 1.00 18.43 A N ATOM 6963 NH2 ARG A 435 43.121 −14.253 11.054 1.00 18.41 A N ATOM 6966 C ARG A 435 44.864 −20.264 11.813 1.00 14.63 A C ATOM 6967 O ARG A 435 45.259 −19.774 12.870 1.00 14.88 A O ATOM 6969 N LEU A 436 44.650 −21.569 11.651 1.00 14.88 A N ATOM 6970 CA LEU A 436 44.874 −22.531 12.735 1.00 14.69 A C ATOM 6972 CB LEU A 436 44.567 −23.964 12.274 1.00 14.43 A C ATOM 6975 CG LEU A 436 43.095 −24.373 12.141 1.00 12.91 A C ATOM 6977 CD1 LEU A 436 42.975 −25.815 11.667 1.00 9.69 A C ATOM 6981 CD2 LEU A 436 42.353 −24.194 13.454 1.00 11.60 A C ATOM 6985 C LEU A 436 46.300 −22.450 13.302 1.00 15.09 A C ATOM 6986 O LEU A 436 46.480 −22.448 14.519 1.00 15.32 A O ATOM 6988 N CYS A 437 47.303 −22.375 12.429 1.00 15.32 A N ATOM 6989 CA CYS A 437 48.692 −22.223 12.877 1.00 15.91 A C ATOM 6991 CB CYS A 437 49.663 −22.121 11.693 1.00 16.11 A C ATOM 6994 SG CYS A 437 50.204 −23.702 11.009 1.00 15.22 A S ATOM 6996 C CYS A 437 48.848 −20.989 13.763 1.00 16.70 A C ATOM 6997 O CYS A 437 49.285 −21.100 14.910 1.00 17.68 A O ATOM 6999 N ASN A 438 48.485 −19.825 13.224 1.00 16.73 A N ATOM 7000 CA ASN A 438 48.591 −18.548 13.946 1.00 16.68 A C ATOM 7002 CB ASN A 438 47.902 −17.428 13.148 1.00 16.72 A C ATOM 7005 CG ASN A 438 48.141 −16.036 13.733 1.00 16.65 A C ATOM 7006 OD1 ASN A 438 48.240 −15.855 14.947 1.00 18.65 A O ATOM 7007 ND2 ASN A 438 48.214 −15.042 12.858 1.00 16.47 A N ATOM 7010 C ASN A 438 47.993 −18.634 15.349 1.00 16.53 A C ATOM 7011 O ASN A 438 48.666 −18.340 16.343 1.00 16.47 A O ATOM 7013 N ASP A 439 46.735 −19.055 15.417 1.00 16.27 A N ATOM 7014 CA ASP A 439 45.992 −19.076 16.672 1.00 16.30 A C ATOM 7016 CB ASP A 439 44.503 −19.296 16.400 1.00 16.10 A C ATOM 7019 CG ASP A 439 43.872 −18.134 15.650 1.00 15.85 A C ATOM 7020 OD1 ASP A 439 44.623 −17.292 15.112 1.00 14.52 A O ATOM 7021 OD2 ASP A 439 42.626 −18.059 15.598 1.00 16.49 A O ATOM 7022 C ASP A 439 46.527 −20.115 17.660 1.00 16.83 A C ATOM 7023 O ASP A 439 46.451 −19.911 18.874 1.00 17.09 A O ATOM 7025 N LEU A 440 47.067 −21.219 17.145 1.00 17.06 A N ATOM 7026 CA LEU A 440 47.742 −22.215 17.987 1.00 17.22 A C ATOM 7028 CB LEU A 440 48.155 −23.442 17.166 1.00 17.05 A C ATOM 7031 CG LEU A 440 47.100 −24.537 17.019 1.00 15.68 A C ATOM 7033 CD1 LEU A 440 47.460 −25.487 15.894 1.00 15.98 A C ATOM 7037 CD2 LEU A 440 46.955 −25.288 18.321 1.00 15.39 A C ATOM 7041 C LEU A 440 48.972 −21.625 18.680 1.00 18.01 A C ATOM 7042 O LEU A 440 49.261 −21.965 19.830 1.00 17.74 A O ATOM 7044 N ALA A 441 49.685 −20.747 17.972 1.00 18.91 A N ATOM 7045 CA ALA A 441 50.883 −20.083 18.502 1.00 19.53 A C ATOM 7047 CB ALA A 441 51.622 −19.360 17.384 1.00 19.65 A C ATOM 7051 C ALA A 441 50.542 −19.101 19.616 1.00 19.96 A C ATOM 7052 O ALA A 441 51.224 −19.050 20.639 1.00 19.83 A O ATOM 7054 N SER A 442 49.480 −18.328 19.407 1.00 20.77 A N ATOM 7055 CA SER A 442 49.015 −17.350 20.387 1.00 21.70 A C ATOM 7057 CB SER A 442 48.473 −16.122 19.653 1.00 22.02 A C ATOM 7060 OG SER A 442 47.282 −16.440 18.950 1.00 22.89 A O ATOM 7062 C SER A 442 47.926 −17.911 21.312 1.00 22.14 A C ATOM 7063 O SER A 442 47.178 −17.149 21.924 1.00 22.10 A O ATOM 7065 N ALA A 443 47.845 −19.236 21.422 1.00 22.95 A N ATOM 7066 CA ALA A 443 46.762 −19.886 22.161 1.00 23.60 A C ATOM 7068 CB ALA A 443 46.779 −21.396 21.915 1.00 23.77 A C ATOM 7072 C ALA A 443 46.816 −19.592 23.660 1.00 24.06 A C ATOM 7073 O ALA A 443 45.974 −18.857 24.177 1.00 24.06 A O ATOM 7075 N SER A 444 47.813 −20.151 24.344 1.00 24.55 A N ATOM 7076 CA SER A 444 47.912 −20.054 25.806 1.00 24.88 A C ATOM 7078 CB SER A 444 49.039 −20.954 26.324 1.00 24.85 A C ATOM 7081 OG SER A 444 50.274 −20.624 25.714 1.00 25.18 A O ATOM 7083 C SER A 444 48.119 −18.625 26.320 1.00 25.16 A C ATOM 7084 O SER A 444 47.749 −18.315 27.456 1.00 25.37 A O ATOM 7086 N ALA A 445 48.709 −17.764 25.490 1.00 25.22 A N ATOM 7087 CA ALA A 445 48.924 −16.363 25.854 1.00 25.09 A C ATOM 7089 CB ALA A 445 49.820 −15.675 24.832 1.00 25.06 A C ATOM 7093 C ALA A 445 47.598 −15.622 25.971 1.00 25.09 A C ATOM 7094 O ALA A 445 47.333 −14.971 26.980 1.00 25.23 A O ATOM 7096 N GLU A 446 46.766 −15.738 24.939 1.00 25.16 A N ATOM 7097 CA GLU A 446 45.496 −15.009 24.873 1.00 25.34 A C ATOM 7099 CB GLU A 446 44.976 −14.984 23.430 1.00 25.42 A C ATOM 7102 CG GLU A 446 45.884 −14.210 22.473 1.00 26.40 A C ATOM 7105 CD GLU A 446 45.477 −14.336 21.012 1.00 27.93 A C ATOM 7106 OE1 GLU A 446 44.450 −14.988 20.718 1.00 28.81 A O ATOM 7107 OE2 GLU A 446 46.191 −13.776 20.153 1.00 27.41 A O ATOM 7108 C GLU A 446 44.421 −15.561 25.819 1.00 25.11 A C ATOM 7109 O GLU A 446 43.555 −14.812 26.273 1.00 24.91 A O ATOM 7111 N ILE A 447 44.482 −16.859 26.115 1.00 25.06 A N ATOM 7112 CA ILE A 447 43.524 −17.497 27.026 1.00 25.06 A C ATOM 7114 CB ILE A 447 43.578 −19.041 26.936 1.00 25.18 A C ATOM 7116 CG1 ILE A 447 43.192 −19.522 25.535 1.00 25.37 A C ATOM 7119 CD1 ILE A 447 43.705 −20.915 25.217 1.00 24.89 A C ATOM 7123 CG2 ILE A 447 42.642 −19.672 27.963 1.00 24.79 A C ATOM 7127 C ILE A 447 43.793 −17.081 28.473 1.00 25.00 A C ATOM 7128 O ILE A 447 42.862 −16.762 29.216 1.00 25.06 A O ATOM 7130 N ALA A 448 45.066 −17.095 28.864 1.00 24.78 A N ATOM 7131 CA ALA A 448 45.479 −16.656 30.198 1.00 24.75 A C ATOM 7133 CB ALA A 448 46.968 −16.911 30.399 1.00 24.58 A C ATOM 7137 C ALA A 448 45.156 −15.177 30.439 1.00 24.85 A C ATOM 7138 O ALA A 448 44.840 −14.782 31.562 1.00 24.72 A O ATOM 7140 N ARG A 449 45.235 −14.370 29.381 1.00 25.19 A N ATOM 7141 CA ARG A 449 44.895 −12.944 29.453 1.00 25.36 A C ATOM 7143 CB ARG A 449 45.514 −12.181 28.272 1.00 25.38 A C ATOM 7146 CG ARG A 449 47.002 −11.884 28.451 1.00 25.01 A C ATOM 7149 CD ARG A 449 47.559 −10.951 27.375 1.00 23.90 A C ATOM 7152 NE ARG A 449 48.127 −11.685 26.242 1.00 22.76 A N ATOM 7154 CZ ARG A 449 47.765 −11.558 24.963 1.00 23.10 A C ATOM 7155 NH1 ARG A 449 46.817 −10.705 24.588 1.00 22.37 A N ATOM 7158 NH2 ARG A 449 48.374 −12.295 24.037 1.00 24.00 A N ATOM 7161 C ARG A 449 43.382 −12.686 29.517 1.00 25.70 A C ATOM 7162 O ARG A 449 42.958 −11.579 29.853 1.00 25.66 A O ATOM 7164 N GLY A 450 42.579 −13.699 29.190 1.00 26.09 A N ATOM 7165 CA GLY A 450 41.121 −13.619 29.310 1.00 26.27 A C ATOM 7168 C GLY A 450 40.432 −13.118 28.054 1.00 26.55 A C ATOM 7169 O GLY A 450 39.447 −12.383 28.132 1.00 26.90 A O ATOM 7171 N GLU A 451 40.949 −13.523 26.895 1.00 26.64 A N ATOM 7172 CA GLU A 451 40.382 −13.141 25.602 1.00 26.67 A C ATOM 7174 CB GLU A 451 41.475 −12.562 24.701 1.00 27.07 A C ATOM 7177 CG GLU A 451 42.137 −11.307 25.255 1.00 27.64 A C ATOM 7180 CD GLU A 451 43.464 −11.004 24.583 1.00 29.26 A C ATOM 7181 OE1 GLU A 451 43.516 −10.980 23.333 1.00 28.51 A O ATOM 7182 OE2 GLU A 451 44.455 −10.789 25.312 1.00 30.56 A O ATOM 7183 C GLU A 451 39.731 −14.348 24.925 1.00 26.15 A C ATOM 7184 O GLU A 451 39.901 −15.485 25.369 1.00 26.18 A O ATOM 7186 N THR A 452 38.986 −14.089 23.853 1.00 25.51 A N ATOM 7187 CA THR A 452 38.273 −15.142 23.119 1.00 24.90 A C ATOM 7189 CB THR A 452 36.752 −15.015 23.327 1.00 24.75 A C ATOM 7191 OG1 THR A 452 36.470 −14.915 24.727 1.00 24.32 A O ATOM 7193 CG2 THR A 452 36.021 −16.222 22.756 1.00 24.68 A C ATOM 7197 C THR A 452 38.560 −15.175 21.609 1.00 24.60 A C ATOM 7198 O THR A 452 38.318 −16.200 20.964 1.00 24.57 A O ATOM 7200 N ALA A 453 39.066 −14.073 21.049 1.00 23.97 A N ATOM 7201 CA ALA A 453 39.372 −13.991 19.613 1.00 23.32 A C ATOM 7203 CB ALA A 453 39.710 −12.550 19.216 1.00 23.40 A C ATOM 7207 C ALA A 453 40.515 −14.935 19.237 1.00 22.48 A C ATOM 7208 O ALA A 453 41.639 −14.504 18.962 1.00 22.66 A O ATOM 7210 N ASN A 454 40.201 −16.228 19.220 1.00 21.33 A N ATOM 7211 CA ASN A 454 41.191 −17.281 19.038 1.00 20.43 A C ATOM 7213 CB ASN A 454 42.047 −17.415 20.297 1.00 20.27 A C ATOM 7216 CG ASN A 454 43.269 −18.277 20.082 1.00 20.86 A C ATOM 7217 OD1 ASN A 454 43.160 −19.454 19.740 1.00 22.12 A O ATOM 7218 ND2 ASN A 454 44.445 −17.697 20.294 1.00 22.69 A N ATOM 7221 C ASN A 454 40.488 −18.602 18.733 1.00 19.67 A C ATOM 7222 O ASN A 454 39.513 −18.957 19.396 1.00 19.58 A O ATOM 7224 N SER A 455 40.986 −19.320 17.731 1.00 18.91 A N ATOM 7225 CA SER A 455 40.347 −20.549 17.264 1.00 18.58 A C ATOM 7227 CB SER A 455 41.080 −21.092 16.040 1.00 18.57 A C ATOM 7230 OG SER A 455 41.081 −20.136 14.995 1.00 18.90 A O ATOM 7232 C SER A 455 40.294 −21.619 18.348 1.00 18.43 A C ATOM 7233 O SER A 455 39.274 −22.289 18.517 1.00 18.43 A O ATOM 7235 N VAL A 456 41.395 −21.765 19.081 1.00 18.24 A N ATOM 7236 CA VAL A 456 41.476 −22.719 20.189 1.00 17.99 A C ATOM 7238 CB VAL A 456 42.896 −22.755 20.804 1.00 17.68 A C ATOM 7240 CG1 VAL A 456 43.002 −23.866 21.837 1.00 17.09 A C ATOM 7244 CG2 VAL A 456 43.950 −22.931 19.720 1.00 17.17 A C ATOM 7248 C VAL A 456 40.472 −22.360 21.290 1.00 18.30 A C ATOM 7249 O VAL A 456 39.855 −23.240 21.891 1.00 18.13 A O ATOM 7251 N SER A 457 40.314 −21.062 21.537 1.00 18.70 A N ATOM 7252 CA SER A 457 39.420 −20.564 22.579 1.00 18.75 A C ATOM 7254 CB SER A 457 39.593 −19.050 22.748 1.00 18.60 A C ATOM 7257 OG SER A 457 38.845 −18.568 23.849 1.00 19.53 A O ATOM 7259 C SER A 457 37.961 −20.887 22.276 1.00 18.84 A C ATOM 7260 O SER A 457 37.233 −21.352 23.151 1.00 19.03 A O ATOM 7262 N CYS A 458 37.540 −20.641 21.038 1.00 19.02 A N ATOM 7263 CA CYS A 458 36.150 −20.883 20.639 1.00 19.32 A C ATOM 7265 CB CYS A 458 35.820 −20.159 19.328 1.00 19.42 A C ATOM 7268 SG CYS A 458 35.508 −18.389 19.544 1.00 20.53 A S ATOM 7270 C CYS A 458 35.811 −22.373 20.530 1.00 19.33 A C ATOM 7271 O CYS A 458 34.639 −22.746 20.610 1.00 19.60 A O ATOM 7273 N TYR A 459 36.827 −23.218 20.355 1.00 19.09 A N ATOM 7274 CA TYR A 459 36.622 −24.666 20.365 1.00 18.87 A C ATOM 7276 CB TYR A 459 37.841 −25.402 19.805 1.00 18.80 A C ATOM 7279 CG TYR A 459 37.543 −26.809 19.320 1.00 17.90 A C ATOM 7280 CD1 TYR A 459 37.163 −27.044 17.999 1.00 15.79 A C ATOM 7282 CE1 TYR A 459 36.890 −28.327 17.546 1.00 15.20 A C ATOM 7284 CZ TYR A 459 36.998 −29.398 18.415 1.00 16.33 A C ATOM 7285 OH TYR A 459 36.728 −30.670 17.962 1.00 17.00 A O ATOM 7287 CE2 TYR A 459 37.375 −29.194 19.734 1.00 16.42 A C ATOM 7289 CD2 TYR A 459 37.646 −27.903 20.179 1.00 17.05 A C ATOM 7291 C TYR A 459 36.332 −25.124 21.792 1.00 19.29 A C ATOM 7292 O TYR A 459 35.353 −25.834 22.029 1.00 19.45 A O ATOM 7294 N MET A 460 37.182 −24.704 22.733 1.00 19.66 A N ATOM 7295 CA MET A 460 36.959 −24.942 24.166 1.00 20.09 A C ATOM 7297 CB MET A 460 37.907 −24.088 25.020 1.00 20.44 A C ATOM 7300 CG MET A 460 39.363 −24.535 25.035 1.00 21.37 A C ATOM 7303 SD MET A 460 40.403 −23.446 26.040 1.00 20.41 A S ATOM 7304 CE MET A 460 39.710 −23.720 27.672 1.00 20.51 A C ATOM 7308 C MET A 460 35.526 −24.602 24.568 1.00 20.02 A C ATOM 7309 O MET A 460 34.881 −25.354 25.299 1.00 20.55 A O ATOM 7311 N ARG A 461 35.044 −23.460 24.087 1.00 19.56 A N ATOM 7312 CA ARG A 461 33.701 −22.985 24.402 1.00 19.46 A C ATOM 7314 CB ARG A 461 33.576 −21.506 24.032 1.00 19.44 A C ATOM 7317 CG ARG A 461 32.316 −20.828 24.545 1.00 19.32 A C ATOM 7320 CD ARG A 461 32.420 −19.311 24.446 1.00 20.04 A C ATOM 7323 NE ARG A 461 32.757 −18.860 23.095 1.00 20.53 A N ATOM 7325 CZ ARG A 461 32.925 −17.587 22.743 1.00 21.06 A C ATOM 7326 NH1 ARG A 461 32.781 −16.609 23.634 1.00 20.57 A N ATOM 7329 NH2 ARG A 461 33.238 −17.287 21.486 1.00 22.20 A N ATOM 7332 C ARG A 461 32.622 −23.797 23.685 1.00 19.27 A C ATOM 7333 O ARG A 461 31.605 −24.142 24.283 1.00 19.05 A O ATOM 7335 N THR A 462 32.852 −24.099 22.409 1.00 19.32 A N ATOM 7336 CA THR A 462 31.871 −24.814 21.585 1.00 19.62 A C ATOM 7338 CB THR A 462 32.292 −24.821 20.095 1.00 19.63 A C ATOM 7340 OG1 THR A 462 32.065 −23.524 19.532 1.00 20.66 A O ATOM 7342 CG2 THR A 462 31.503 −25.854 19.296 1.00 20.05 A C ATOM 7346 C THR A 462 31.632 −26.253 22.052 1.00 19.82 A C ATOM 7347 O THR A 462 30.487 −26.719 22.084 1.00 20.00 A O ATOM 7349 N LYS A 463 32.710 −26.948 22.413 1.00 19.62 A N ATOM 7350 CA LYS A 463 32.622 −28.345 22.846 1.00 19.23 A C ATOM 7352 CB LYS A 463 33.772 −29.162 22.243 1.00 19.10 A C ATOM 7355 CG LYS A 463 34.023 −28.923 20.754 1.00 17.85 A C ATOM 7358 CD LYS A 463 32.791 −29.169 19.891 1.00 17.09 A C ATOM 7361 CE LYS A 463 33.108 −28.934 18.419 1.00 17.67 A C ATOM 7364 NZ LYS A 463 31.897 −28.942 17.554 1.00 18.35 A N ATOM 7368 C LYS A 463 32.618 −28.499 24.374 1.00 19.01 A C ATOM 7369 O LYS A 463 32.385 −29.597 24.883 1.00 18.88 A O ATOM 7371 N GLY A 464 32.875 −27.407 25.095 1.00 18.78 A N ATOM 7372 CA GLY A 464 32.929 −27.434 26.557 1.00 18.68 A C ATOM 7375 C GLY A 464 34.040 −28.331 27.067 1.00 18.63 A C ATOM 7376 O GLY A 464 33.780 −29.294 27.790 1.00 18.57 A O ATOM 7378 N ILE A 465 35.278 −28.015 26.685 1.00 18.68 A N ATOM 7379 CA ILE A 465 36.439 −28.853 27.006 1.00 18.82 A C ATOM 7381 CB ILE A 465 36.788 −29.812 25.838 1.00 18.83 A C ATOM 7383 CG1 ILE A 465 37.004 −29.035 24.534 1.00 18.84 A C ATOM 7386 CD1 ILE A 465 37.345 −29.915 23.345 1.00 18.16 A C ATOM 7390 CG2 ILE A 465 35.689 −30.848 25.660 1.00 19.72 A C ATOM 7394 C ILE A 465 37.682 −28.039 27.370 1.00 18.85 A C ATOM 7395 O ILE A 465 37.736 −26.826 27.153 1.00 18.44 A O ATOM 7397 N SER A 466 38.676 −28.731 27.920 1.00 19.23 A N ATOM 7398 CA SER A 466 39.912 −28.108 28.384 1.00 19.68 A C ATOM 7400 CB SER A 466 40.667 −29.071 29.304 1.00 19.87 A C ATOM 7403 OG SER A 466 40.980 −30.278 28.628 1.00 19.96 A O ATOM 7405 C SER A 466 40.811 −27.707 27.221 1.00 20.03 A C ATOM 7406 O SER A 466 40.670 −28.225 26.114 1.00 19.89 A O ATOM 7408 N GLU A 467 41.746 −26.797 27.491 1.00 20.78 A N ATOM 7409 CA GLU A 467 42.673 −26.283 26.472 1.00 21.37 A C ATOM 7411 CB GLU A 467 43.576 −25.189 27.062 1.00 21.42 A C ATOM 7414 CG GLU A 467 44.408 −24.433 26.022 1.00 21.87 A C ATOM 7417 CD GLU A 467 45.487 −23.565 26.640 1.00 22.82 A C ATOM 7418 OE1 GLU A 467 45.207 −22.883 27.647 1.00 23.89 A O ATOM 7419 OE2 GLU A 467 46.618 −23.560 26.109 1.00 23.99 A O ATOM 7420 C GLU A 467 43.542 −27.377 25.843 1.00 21.81 A C ATOM 7421 O GLU A 467 43.856 −27.309 24.651 1.00 22.00 A O ATOM 7423 N GLU A 468 43.932 −28.373 26.639 1.00 21.90 A N ATOM 7424 CA GLU A 468 44.772 −29.466 26.142 1.00 21.88 A C ATOM 7426 CB GLU A 468 45.304 −30.320 27.298 1.00 22.13 A C ATOM 7429 CG GLU A 468 46.361 −31.336 26.869 1.00 23.30 A C ATOM 7432 CD GLU A 468 46.846 −32.207 28.012 1.00 24.29 A C ATOM 7433 OE1 GLU A 468 47.560 −31.688 28.898 1.00 25.02 A O ATOM 7434 OE2 GLU A 468 46.526 −33.416 28.015 1.00 24.63 A O ATOM 7435 C GLU A 468 44.022 −30.345 25.137 1.00 21.46 A C ATOM 7436 O GLU A 468 44.577 −30.710 24.099 1.00 21.21 A O ATOM 7438 N LEU A 469 42.771 −30.685 25.450 1.00 21.18 A N ATOM 7439 CA LEU A 469 41.919 −31.458 24.531 1.00 20.84 A C ATOM 7441 CB LEU A 469 40.692 −32.042 25.253 1.00 21.05 A C ATOM 7444 CG LEU A 469 40.856 −33.409 25.932 1.00 20.32 A C ATOM 7446 CD1 LEU A 469 41.842 −33.328 27.086 1.00 20.20 A C ATOM 7450 CD2 LEU A 469 39.508 −33.940 26.415 1.00 18.12 A C ATOM 7454 C LEU A 469 41.463 −30.616 23.335 1.00 20.25 A C ATOM 7455 O LEU A 469 41.262 −31.149 22.243 1.00 20.27 A O ATOM 7457 N ALA A 470 41.295 −29.312 23.550 1.00 19.59 A N ATOM 7458 CA ALA A 470 40.901 −28.386 22.484 1.00 19.19 A C ATOM 7460 CB ALA A 470 40.517 −27.037 23.069 1.00 18.89 A C ATOM 7464 C ALA A 470 42.013 −28.213 21.452 1.00 19.15 A C ATOM 7465 O ALA A 470 41.746 −28.143 20.249 1.00 19.34 A O ATOM 7467 N THR A 471 43.254 −28.135 21.931 1.00 18.89 A N ATOM 7468 CA THR A 471 44.426 −28.064 21.059 1.00 18.62 A C ATOM 7470 CB THR A 471 45.732 −27.906 21.884 1.00 18.76 A C ATOM 7472 OG1 THR A 471 45.777 −26.597 22.467 1.00 19.40 A O ATOM 7474 CG2 THR A 471 46.968 −28.103 21.012 1.00 18.57 A C ATOM 7478 C THR A 471 44.515 −29.311 20.179 1.00 18.43 A C ATOM 7479 O THR A 471 44.622 −29.205 18.959 1.00 18.22 A O ATOM 7481 N GLU A 472 44.446 −30.484 20.807 1.00 18.49 A N ATOM 7482 CA GLU A 472 44.564 −31.770 20.107 1.00 18.66 A C ATOM 7484 CB GLU A 472 44.382 −32.928 21.094 1.00 18.91 A C ATOM 7487 CG GLU A 472 44.713 −34.306 20.517 1.00 20.49 A C ATOM 7490 CD GLU A 472 44.356 −35.452 21.450 1.00 21.71 A C ATOM 7491 OE1 GLU A 472 44.795 −36.589 21.175 1.00 22.68 A O ATOM 7492 OE2 GLU A 472 43.637 −35.225 22.448 1.00 22.86 A O ATOM 7493 C GLU A 472 43.569 −31.924 18.951 1.00 18.52 A C ATOM 7494 O GLU A 472 43.896 −32.510 17.917 1.00 17.98 A O ATOM 7496 N SER A 473 42.356 −31.410 19.133 1.00 18.86 A N ATOM 7497 CA SER A 473 41.343 −31.440 18.077 1.00 19.17 A C ATOM 7499 CB SER A 473 39.978 −31.041 18.633 1.00 18.98 A C ATOM 7502 OG SER A 473 39.616 −31.871 19.723 1.00 18.35 A O ATOM 7504 C SER A 473 41.727 −30.519 16.917 1.00 19.64 A C ATOM 7505 O SER A 473 41.518 −30.862 15.749 1.00 20.03 A O ATOM 7507 N VAL A 474 42.287 −29.355 17.248 1.00 19.48 A N ATOM 7508 CA VAL A 474 42.797 −28.424 16.240 1.00 19.38 A C ATOM 7510 CB VAL A 474 43.148 −27.054 16.862 1.00 19.33 A C ATOM 7512 CG1 VAL A 474 43.833 −26.152 15.844 1.00 18.11 A C ATOM 7516 CG2 VAL A 474 41.892 −26.389 17.412 1.00 19.60 A C ATOM 7520 C VAL A 474 44.020 −29.008 15.525 1.00 19.69 A C ATOM 7521 O VAL A 474 44.175 −28.829 14.315 1.00 20.15 A O ATOM 7523 N MET A 475 44.873 −29.714 16.268 1.00 19.66 A N ATOM 7524 CA MET A 475 46.005 −30.444 15.680 1.00 19.70 A C ATOM 7526 CB MET A 475 46.889 −31.053 16.772 1.00 20.05 A C ATOM 7529 CG MET A 475 47.604 −30.045 17.650 1.00 20.04 A C ATOM 7532 SD MET A 475 48.893 −29.161 16.773 1.00 21.08 A S ATOM 7533 CE MET A 475 50.090 −28.966 18.096 1.00 21.33 A C ATOM 7537 C MET A 475 45.528 −31.562 14.751 1.00 19.35 A C ATOM 7538 O MET A 475 46.147 −31.822 13.718 1.00 19.12 A O ATOM 7540 N ASN A 476 44.441 −32.230 15.136 1.00 19.22 A N ATOM 7541 CA ASN A 476 43.791 −33.215 14.270 1.00 19.31 A C ATOM 7543 CB ASN A 476 42.729 −34.021 15.036 1.00 19.59 A C ATOM 7546 CG ASN A 476 43.330 −35.106 15.920 1.00 20.46 A C ATOM 7547 OD1 ASN A 476 44.375 −35.682 15.605 1.00 21.67 A O ATOM 7548 ND2 ASN A 476 42.659 −35.397 17.029 1.00 19.15 A N ATOM 7551 C ASN A 476 43.147 −32.565 13.050 1.00 18.81 A C ATOM 7552 O ASN A 476 43.056 −33.193 11.996 1.00 19.00 A O ATOM 7554 N LEU A 477 42.699 −31.318 13.195 1.00 18.29 A N ATOM 7555 CA LEU A 477 42.084 −30.588 12.083 1.00 18.10 A C ATOM 7557 CB LEU A 477 41.349 −29.331 12.568 1.00 18.33 A C ATOM 7560 CG LEU A 477 40.013 −29.097 11.847 1.00 19.37 A C ATOM 7562 CD1 LEU A 477 38.911 −29.923 12.515 1.00 19.86 A C ATOM 7566 CD2 LEU A 477 39.627 −27.623 11.809 1.00 19.63 A C ATOM 7570 C LEU A 477 43.115 −30.208 11.022 1.00 17.36 A C ATOM 7571 O LEU A 477 42.808 −30.206 9.834 1.00 16.65 A O ATOM 7573 N ILE A 478 44.328 −29.876 11.459 1.00 17.33 A N ATOM 7574 CA ILE A 478 45.438 −29.615 10.540 1.00 17.10 A C ATOM 7576 CB ILE A 478 46.684 −29.070 11.278 1.00 16.99 A C ATOM 7578 CG1 ILE A 478 46.479 −27.597 11.646 1.00 15.91 A C ATOM 7581 CD1 ILE A 478 47.583 −27.015 12.513 1.00 14.00 A C ATOM 7585 CG2 ILE A 478 47.928 −29.216 10.418 1.00 16.35 A C ATOM 7589 C ILE A 478 45.797 −30.895 9.796 1.00 17.29 A C ATOM 7590 O ILE A 478 45.765 −30.928 8.566 1.00 16.88 A O ATOM 7592 N ASP A 479 46.124 −31.946 10.547 1.00 17.99 A N ATOM 7593 CA ASP A 479 46.388 −33.264 9.962 1.00 18.84 A C ATOM 7595 CB ASP A 479 46.434 −34.355 11.047 1.00 19.10 A C ATOM 7598 CG ASP A 479 47.715 −34.320 11.885 1.00 20.09 A C ATOM 7599 OD1 ASP A 479 48.759 −33.837 11.398 1.00 23.06 A O ATOM 7600 OD2 ASP A 479 47.678 −34.799 13.039 1.00 20.40 A O ATOM 7601 C ASP A 479 45.316 −33.616 8.926 1.00 19.15 A C ATOM 7602 O ASP A 479 45.633 −34.020 7.807 1.00 19.09 A O ATOM 7604 N GLU A 480 44.052 −33.439 9.307 1.00 19.60 A N ATOM 7605 CA GLU A 480 42.914 −33.728 8.431 1.00 19.98 A C ATOM 7607 CB GLU A 480 41.602 −33.582 9.207 1.00 19.86 A C ATOM 7610 CG GLU A 480 40.347 −33.858 8.393 1.00 20.57 A C ATOM 7613 CD GLU A 480 39.126 −34.088 9.268 1.00 22.39 A C ATOM 7614 OE1 GLU A 480 39.083 −35.116 9.982 1.00 22.35 A O ATOM 7615 OE2 GLU A 480 38.205 −33.244 9.233 1.00 22.18 A O ATOM 7616 C GLU A 480 42.885 −32.835 7.190 1.00 20.39 A C ATOM 7617 O GLU A 480 42.571 −33.303 6.095 1.00 20.59 A O ATOM 7619 N THR A 481 43.202 −31.553 7.364 1.00 20.68 A N ATOM 7620 CA THR A 481 43.218 −30.604 6.249 1.00 20.31 A C ATOM 7622 CB THR A 481 43.298 −29.143 6.737 1.00 20.04 A C ATOM 7624 OG1 THR A 481 42.259 −28.899 7.690 1.00 20.12 A O ATOM 7626 CG2 THR A 481 43.131 −28.179 5.577 1.00 19.56 A C ATOM 7630 C THR A 481 44.378 −30.897 5.297 1.00 20.57 A C ATOM 7631 O THR A 481 44.217 −30.791 4.080 1.00 21.43 A O ATOM 7633 N TRP A 482 45.537 −31.268 5.846 1.00 19.91 A N ATOM 7634 CA TRP A 482 46.673 −31.698 5.020 1.00 19.35 A C ATOM 7636 CB TRP A 482 47.922 −31.978 5.873 1.00 19.46 A C ATOM 7639 CG TRP A 482 48.839 −30.798 5.995 1.00 19.49 A C ATOM 7640 CD1 TRP A 482 48.961 −29.963 7.064 1.00 19.76 A C ATOM 7642 NE1 TRP A 482 49.900 −28.996 6.805 1.00 18.99 A N ATOM 7644 CE2 TRP A 482 50.403 −29.191 5.547 1.00 19.41 A C ATOM 7645 CD2 TRP A 482 49.757 −30.320 5.005 1.00 18.58 A C ATOM 7646 CE3 TRP A 482 50.095 −30.737 3.714 1.00 18.27 A C ATOM 7648 CZ3 TRP A 482 51.055 −30.024 3.014 1.00 19.21 A C ATOM 7650 CH2 TRP A 482 51.681 −28.902 3.581 1.00 20.66 A C ATOM 7652 CZ2 TRP A 482 51.369 −28.470 4.842 1.00 19.87 A C ATOM 7654 C TRP A 482 46.333 −32.933 4.186 1.00 18.89 A C ATOM 7655 O TRP A 482 46.780 −33.055 3.048 1.00 18.56 A O ATOM 7657 N LYS A 483 45.544 −33.842 4.753 1.00 18.60 A N ATOM 7658 CA LYS A 483 45.126 −35.045 4.034 1.00 18.61 A C ATOM 7660 CB LYS A 483 44.344 −35.996 4.953 1.00 18.82 A C ATOM 7663 CG LYS A 483 45.198 −36.750 5.972 1.00 17.67 A C ATOM 7666 CD LYS A 483 44.331 −37.423 7.032 1.00 15.32 A C ATOM 7669 CE LYS A 483 45.158 −38.283 7.970 1.00 13.29 A C ATOM 7672 NZ LYS A 483 44.317 −38.976 8.975 1.00 11.47 A N ATOM 7676 C LYS A 483 44.288 −34.699 2.803 1.00 18.60 A C ATOM 7677 O LYS A 483 44.480 −35.279 1.737 1.00 19.08 A O ATOM 7679 N LYS A 484 43.365 −33.755 2.953 1.00 18.44 A N ATOM 7680 CA LYS A 484 42.497 −33.350 1.848 1.00 18.75 A C ATOM 7682 CB LYS A 484 41.273 −32.596 2.375 1.00 19.23 A C ATOM 7685 CG LYS A 484 40.298 −33.472 3.160 1.00 20.08 A C ATOM 7688 CD LYS A 484 39.154 −32.644 3.749 1.00 21.14 A C ATOM 7691 CE LYS A 484 38.400 −33.410 4.825 1.00 21.14 A C ATOM 7694 NZ LYS A 484 37.453 −32.542 5.575 1.00 21.03 A N ATOM 7698 C LYS A 484 43.229 −32.506 0.799 1.00 18.54 A C ATOM 7699 O LYS A 484 42.816 −32.464 −0.362 1.00 18.32 A O ATOM 7701 N MET A 485 44.303 −31.832 1.206 1.00 18.57 A N ATOM 7702 CA MET A 485 45.123 −31.055 0.271 1.00 18.64 A C ATOM 7704 CB MET A 485 45.980 −30.024 1.012 1.00 18.40 A C ATOM 7707 CG MET A 485 45.227 −28.776 1.434 1.00 18.70 A C ATOM 7710 SD MET A 485 46.323 −27.453 1.994 1.00 20.00 A S ATOM 7711 CE MET A 485 47.030 −28.185 3.470 1.00 21.42 A C ATOM 7715 C MET A 485 46.018 −31.957 −0.579 1.00 18.87 A C ATOM 7716 O MET A 485 46.335 −31.620 −1.718 1.00 19.09 A O ATOM 7718 N ASN A 486 46.423 −33.097 −0.024 1.00 19.18 A N ATOM 7719 CA ASN A 486 47.263 −34.055 −0.747 1.00 19.51 A C ATOM 7721 CB ASN A 486 47.949 −35.011 0.234 1.00 19.57 A C ATOM 7724 CG ASN A 486 48.863 −34.291 1.215 1.00 18.76 A C ATOM 7725 OD1 ASN A 486 49.319 −33.176 0.955 1.00 16.76 A O ATOM 7726 ND2 ASN A 486 49.129 −34.926 2.353 1.00 15.82 A N ATOM 7729 C ASN A 486 46.484 −34.844 −1.805 1.00 19.93 A C ATOM 7730 O ASN A 486 47.079 −35.465 −2.686 1.00 19.71 A O ATOM 7732 N LYS A 487 45.157 −34.825 −1.699 1.00 20.76 A N ATOM 7733 CA LYS A 487 44.270 −35.350 −2.740 1.00 21.38 A C ATOM 7735 CB LYS A 487 42.876 −35.618 −2.155 1.00 21.37 A C ATOM 7738 CG LYS A 487 41.863 −36.168 −3.146 1.00 22.41 A C ATOM 7741 CD LYS A 487 40.657 −36.762 −2.429 1.00 24.55 A C ATOM 7744 CE LYS A 487 39.699 −37.429 −3.406 1.00 25.58 A C ATOM 7747 NZ LYS A 487 38.641 −38.214 −2.712 1.00 25.77 A N ATOM 7751 C LYS A 487 44.173 −34.357 −3.902 1.00 21.61 A C ATOM 7752 O LYS A 487 44.198 −34.750 −5.069 1.00 21.31 A O ATOM 7754 N GLU A 488 44.066 −33.073 −3.563 1.00 22.02 A N ATOM 7755 CA GLU A 488 43.961 −31.991 −4.548 1.00 22.50 A C ATOM 7757 CB GLU A 488 43.814 −30.642 −3.829 1.00 22.80 A C ATOM 7760 CG GLU A 488 43.213 −29.533 −4.676 1.00 23.18 A C ATOM 7763 CD GLU A 488 41.700 −29.614 −4.749 1.00 24.54 A C ATOM 7764 OE1 GLU A 488 41.174 −30.005 −5.813 1.00 26.04 A O ATOM 7765 OE2 GLU A 488 41.037 −29.300 −3.736 1.00 23.72 A O ATOM 7766 C GLU A 488 45.175 −31.939 −5.484 1.00 22.62 A C ATOM 7767 O GLU A 488 45.030 −31.728 −6.692 1.00 22.91 A O ATOM 7769 N LYS A 489 46.364 −32.126 −4.914 1.00 22.30 A N ATOM 7770 CA LYS A 489 47.612 −32.113 −5.679 1.00 22.00 A C ATOM 7772 CB LYS A 489 48.811 −32.096 −4.722 1.00 21.67 A C ATOM 7775 CG LYS A 489 50.184 −32.043 −5.393 1.00 21.43 A C ATOM 7778 CD LYS A 489 50.461 −30.695 −6.050 1.00 20.14 A C ATOM 7781 CE LYS A 489 51.730 −30.743 −6.890 1.00 19.82 A C ATOM 7784 NZ LYS A 489 52.931 −31.125 −6.095 1.00 17.92 A N ATOM 7788 C LYS A 489 47.701 −33.322 −6.611 1.00 22.11 A C ATOM 7789 O LYS A 489 48.096 −33.198 −7.773 1.00 21.65 A O ATOM 7791 N LEU A 490 47.327 −34.488 −6.093 1.00 22.42 A N ATOM 7792 CA LEU A 490 47.446 −35.738 −6.839 1.00 22.44 A C ATOM 7794 CB LEU A 490 47.168 −36.947 −5.931 1.00 22.44 A C ATOM 7797 CG LEU A 490 47.979 −38.212 −6.227 1.00 21.83 A C ATOM 7799 CD1 LEU A 490 49.430 −38.021 −5.803 1.00 20.81 A C ATOM 7803 CD2 LEU A 490 47.375 −39.425 −5.528 1.00 22.00 A C ATOM 7807 C LEU A 490 46.513 −35.751 −8.049 1.00 22.61 A C ATOM 7808 O LEU A 490 46.851 −36.327 −9.084 1.00 22.97 A O ATOM 7810 N GLY A 491 45.347 −35.118 −7.919 1.00 22.59 A N ATOM 7811 CA GLY A 491 44.416 −35.003 −9.038 1.00 22.92 A C ATOM 7814 C GLY A 491 43.025 −34.538 −8.654 1.00 23.38 A C ATOM 7815 O GLY A 491 42.667 −34.519 −7.479 1.00 23.58 A O ATOM 7817 N GLY A 492 42.242 −34.164 −9.662 1.00 24.00 A N ATOM 7818 CA GLY A 492 40.868 −33.719 −9.464 1.00 24.68 A C ATOM 7821 C GLY A 492 40.714 −32.217 −9.284 1.00 25.47 A C ATOM 7822 O GLY A 492 39.590 −31.710 −9.219 1.00 26.12 A O ATOM 7824 N SER A 493 41.829 −31.495 −9.204 1.00 25.71 A N ATOM 7825 CA SER A 493 41.777 −30.049 −9.019 1.00 25.75 A C ATOM 7827 CB SER A 493 43.159 −29.494 −8.656 1.00 26.12 A C ATOM 7830 OG SER A 493 43.108 −28.096 −8.407 1.00 25.68 A O ATOM 7832 C SER A 493 41.268 −29.373 −10.287 1.00 25.36 A C ATOM 7833 O SER A 493 41.558 −29.836 −11.390 1.00 25.36 A O ATOM 7835 N PRO A 494 40.493 −28.285 −10.134 1.00 25.03 A N ATOM 7836 CA PRO A 494 40.128 −27.456 −11.280 1.00 24.84 A C ATOM 7838 CB PRO A 494 38.930 −26.657 −10.766 1.00 24.98 A C ATOM 7841 CG PRO A 494 39.143 −26.559 −9.306 1.00 25.14 A C ATOM 7844 CD PRO A 494 39.871 −27.804 −8.887 1.00 25.07 A C ATOM 7847 C PRO A 494 41.269 −26.525 −11.699 1.00 24.33 A C ATOM 7848 O PRO A 494 41.251 −25.992 −12.809 1.00 24.46 A O ATOM 7849 N PHE A 495 42.242 −26.332 −10.809 1.00 23.65 A N ATOM 7850 CA PHE A 495 43.440 −25.554 −11.110 1.00 23.36 A C ATOM 7852 CB PHE A 495 43.903 −24.783 −9.872 1.00 23.58 A C ATOM 7855 CG PHE A 495 42.904 −23.784 −9.374 1.00 23.05 A C ATOM 7856 CD1 PHE A 495 42.977 −22.457 −9.760 1.00 21.76 A C ATOM 7858 CE1 PHE A 495 42.052 −21.539 −9.302 1.00 22.61 A C ATOM 7860 CZ PHE A 495 41.036 −21.946 −8.454 1.00 22.69 A C ATOM 7862 CE2 PHE A 495 40.953 −23.264 −8.068 1.00 23.16 A C ATOM 7864 CD2 PHE A 495 41.883 −24.175 −8.525 1.00 23.51 A C ATOM 7866 C PHE A 495 44.561 −26.470 −11.576 1.00 23.05 A C ATOM 7867 O PHE A 495 44.538 −27.676 −11.325 1.00 22.76 A O ATOM 7869 N ALA A 496 45.545 −25.886 −12.253 1.00 22.91 A N ATOM 7870 CA ALA A 496 46.730 −26.622 −12.677 1.00 22.83 A C ATOM 7872 CB ALA A 496 47.528 −25.806 −13.681 1.00 23.00 A C ATOM 7876 C ALA A 496 47.586 −26.957 −11.461 1.00 22.74 A C ATOM 7877 O ALA A 496 47.573 −26.229 −10.469 1.00 23.03 A O ATOM 7879 N LYS A 497 48.331 −28.056 −11.544 1.00 22.67 A N ATOM 7880 CA LYS A 497 49.160 −28.523 −10.424 1.00 22.50 A C ATOM 7882 CB LYS A 497 49.887 −29.828 −10.785 1.00 22.80 A C ATOM 7885 CG LYS A 497 48.946 −31.004 −11.042 1.00 24.08 A C ATOM 7888 CD LYS A 497 49.679 −32.344 −11.050 1.00 24.82 A C ATOM 7891 CE LYS A 497 48.703 −33.508 −11.215 1.00 24.18 A C ATOM 7894 NZ LYS A 497 49.301 −34.815 −10.828 1.00 23.44 A N ATOM 7898 C LYS A 497 50.161 −27.474 −9.917 1.00 21.54 A C ATOM 7899 O LYS A 497 50.391 −27.385 −8.712 1.00 21.63 A O ATOM 7901 N PRO A 498 50.763 −26.684 −10.828 1.00 20.42 A N ATOM 7902 CA PRO A 498 51.606 −25.575 −10.392 1.00 19.81 A C ATOM 7904 CB PRO A 498 51.853 −24.807 −11.689 1.00 20.02 A C ATOM 7907 CG PRO A 498 51.868 −25.858 −12.730 1.00 20.71 A C ATOM 7910 CD PRO A 498 50.921 −26.940 −12.272 1.00 20.44 A C ATOM 7913 C PRO A 498 50.954 −24.665 −9.353 1.00 19.16 A C ATOM 7914 O PRO A 498 51.549 −24.416 −8.304 1.00 19.10 A O ATOM 7915 N PHE A 499 49.745 −24.184 −9.636 1.00 18.41 A N ATOM 7916 CA PHE A 499 49.067 −23.259 −8.725 1.00 17.71 A C ATOM 7918 CB PHE A 499 47.876 −22.577 −9.394 1.00 17.65 A C ATOM 7921 CG PHE A 499 47.125 −21.666 −8.469 1.00 17.11 A C ATOM 7922 CD1 PHE A 499 47.733 −20.525 −7.964 1.00 15.75 A C ATOM 7924 CE1 PHE A 499 47.059 −19.686 −7.097 1.00 16.82 A C ATOM 7926 CZ PHE A 499 45.760 −19.985 −6.715 1.00 18.26 A C ATOM 7928 CE2 PHE A 499 45.146 −21.128 −7.203 1.00 19.35 A C ATOM 7930 CD2 PHE A 499 45.833 −21.966 −8.071 1.00 18.48 A C ATOM 7932 C PHE A 499 48.594 −23.918 −7.432 1.00 17.27 A C ATOM 7933 O PHE A 499 48.608 −23.283 −6.377 1.00 18.04 A O ATOM 7935 N VAL A 500 48.156 −25.173 −7.520 1.00 16.13 A N ATOM 7936 CA VAL A 500 47.787 −25.947 −6.334 1.00 15.18 A C ATOM 7938 CB VAL A 500 47.344 −27.381 −6.710 1.00 15.13 A C ATOM 7940 CG1 VAL A 500 46.049 −27.346 −7.503 1.00 15.59 A C ATOM 7944 CG2 VAL A 500 47.181 −28.247 −5.466 1.00 15.76 A C ATOM 7948 C VAL A 500 48.972 −26.003 −5.367 1.00 14.53 A C ATOM 7949 O VAL A 500 48.834 −25.683 −4.184 1.00 14.32 A O ATOM 7951 N GLU A 501 50.134 −26.391 −5.893 1.00 13.78 A N ATOM 7952 CA GLU A 501 51.380 −26.469 −5.126 1.00 13.17 A C ATOM 7954 CB GLU A 501 52.516 −26.953 −6.033 1.00 13.27 A C ATOM 7957 CG GLU A 501 53.883 −27.124 −5.355 1.00 12.99 A C ATOM 7960 CD GLU A 501 53.936 −28.270 −4.360 1.00 10.75 A C ATOM 7961 OE1 GLU A 501 53.035 −29.135 −4.365 1.00 9.48 A O ATOM 7962 OE2 GLU A 501 54.899 −28.308 −3.571 1.00 9.39 A O ATOM 7963 C GLU A 501 51.759 −25.126 −4.505 1.00 13.02 A C ATOM 7964 O GLU A 501 52.309 −25.083 −3.403 1.00 12.70 A O ATOM 7966 N THR A 502 51.479 −24.037 −5.218 1.00 13.13 A N ATOM 7967 CA THR A 502 51.715 −22.696 −4.689 1.00 12.94 A C ATOM 7969 CB THR A 502 51.408 −21.597 −5.724 1.00 12.49 A C ATOM 7971 OG1 THR A 502 51.913 −21.986 −7.007 1.00 12.30 A O ATOM 7973 CG2 THR A 502 52.045 −20.281 −5.314 1.00 11.05 A C ATOM 7977 C THR A 502 50.849 −22.481 −3.453 1.00 13.75 A C ATOM 7978 O THR A 502 51.323 −21.947 −2.451 1.00 14.63 A O ATOM 7980 N ALA A 503 49.587 −22.912 −3.526 1.00 13.85 A N ATOM 7981 CA ALA A 503 48.671 −22.838 −2.386 1.00 13.85 A C ATOM 7983 CB ALA A 503 47.298 −23.367 −2.766 1.00 13.55 A C ATOM 7987 C ALA A 503 49.229 −23.619 −1.202 1.00 14.25 A C ATOM 7988 O ALA A 503 49.414 −23.068 −0.115 1.00 14.42 A O ATOM 7990 N ILE A 504 49.517 −24.899 −1.426 1.00 14.43 A N ATOM 7991 CA ILE A 504 50.082 −25.762 −0.385 1.00 14.49 A C ATOM 7993 CB ILE A 504 50.462 −27.159 −0.950 1.00 14.26 A C ATOM 7995 CG1 ILE A 504 49.197 −27.968 −1.258 1.00 13.75 A C ATOM 7998 CD1 ILE A 504 49.450 −29.249 −2.022 1.00 11.62 A C ATOM 8002 CG2 ILE A 504 51.333 −27.928 0.032 1.00 13.71 A C ATOM 8006 C ILE A 504 51.293 −25.097 0.278 1.00 15.04 A C ATOM 8007 O ILE A 504 51.449 −25.159 1.498 1.00 15.26 A O ATOM 8009 N ASN A 505 52.125 −24.438 −0.526 1.00 15.57 A N ATOM 8010 CA ASN A 505 53.295 −23.716 −0.014 1.00 16.27 A C ATOM 8012 CB ASN A 505 54.117 −23.135 −1.175 1.00 16.20 A C ATOM 8015 CG ASN A 505 54.937 −24.191 −1.910 1.00 16.68 A C ATOM 8016 OD1 ASN A 505 55.408 −25.164 −1.317 1.00 14.13 A O ATOM 8017 ND2 ASN A 505 55.122 −23.989 −3.213 1.00 16.63 A N ATOM 8020 C ASN A 505 52.973 −22.607 1.014 1.00 16.76 A C ATOM 8021 O ASN A 505 53.840 −22.239 1.811 1.00 17.12 A O ATOM 8023 N LEU A 506 51.749 −22.074 0.995 1.00 16.63 A N ATOM 8024 CA LEU A 506 51.303 −21.135 2.034 1.00 16.26 A C ATOM 8026 CB LEU A 506 49.936 −20.530 1.694 1.00 16.36 A C ATOM 8029 CG LEU A 506 49.433 −19.409 2.615 1.00 15.61 A C ATOM 8031 CD1 LEU A 506 50.134 −18.100 2.305 1.00 16.15 A C ATOM 8035 CD2 LEU A 506 47.930 −19.241 2.488 1.00 15.78 A C ATOM 8039 C LEU A 506 51.220 −21.858 3.373 1.00 16.06 A C ATOM 8040 O LEU A 506 51.719 −21.363 4.387 1.00 15.94 A O ATOM 8042 N ALA A 507 50.582 −23.028 3.367 1.00 15.76 A N ATOM 8043 CA ALA A 507 50.483 −23.862 4.563 1.00 15.58 A C ATOM 8045 CB ALA A 507 49.733 −25.148 4.257 1.00 15.54 A C ATOM 8049 C ALA A 507 51.867 −24.178 5.109 1.00 15.59 A C ATOM 8050 O ALA A 507 52.095 −24.098 6.316 1.00 14.90 A O ATOM 8052 N ARG A 508 52.787 −24.531 4.210 1.00 16.16 A N ATOM 8053 CA ARG A 508 54.174 −24.806 4.585 1.00 16.29 A C ATOM 8055 CB ARG A 508 55.026 −25.165 3.364 1.00 16.26 A C ATOM 8058 CG ARG A 508 54.660 −26.473 2.679 1.00 17.94 A C ATOM 8061 CD ARG A 508 55.608 −26.763 1.521 1.00 19.98 A C ATOM 8064 NE ARG A 508 54.905 −27.288 0.346 1.00 21.98 A N ATOM 8066 CZ ARG A 508 54.787 −28.577 0.019 1.00 22.61 A C ATOM 8067 NH1 ARG A 508 55.324 −29.538 0.767 1.00 22.88 A N ATOM 8070 NH2 ARG A 508 54.120 −28.910 −1.080 1.00 22.72 A N ATOM 8073 C ARG A 508 54.783 −23.598 5.274 1.00 16.50 A C ATOM 8074 O ARG A 508 55.366 −23.724 6.347 1.00 16.45 A O ATOM 8076 N GLN A 509 54.634 −22.430 4.652 1.00 17.01 A N ATOM 8077 CA GLN A 509 55.139 −21.180 5.218 1.00 17.44 A C ATOM 8079 CB GLN A 509 54.932 −20.022 4.233 1.00 17.64 A C ATOM 8082 CG GLN A 509 55.378 −18.640 4.743 1.00 18.86 A C ATOM 8085 CD GLN A 509 56.866 −18.559 5.059 1.00 19.80 A C ATOM 8086 OE1 GLN A 509 57.698 −19.142 4.364 1.00 21.40 A O ATOM 8087 NE2 GLN A 509 57.205 −17.824 6.109 1.00 20.43 A N ATOM 8090 C GLN A 509 54.489 −20.856 6.566 1.00 17.62 A C ATOM 8091 O GLN A 509 55.147 −20.310 7.452 1.00 17.58 A O ATOM 8093 N SER A 510 53.208 −21.190 6.722 1.00 18.00 A N ATOM 8094 CA SER A 510 52.519 −20.976 7.995 1.00 18.54 A C ATOM 8096 CB SER A 510 51.036 −21.331 7.892 1.00 18.47 A C ATOM 8099 OG SER A 510 50.356 −20.392 7.083 1.00 18.50 A O ATOM 8101 C SER A 510 53.182 −21.778 9.109 1.00 19.15 A C ATOM 8102 O SER A 510 53.583 −21.212 10.124 1.00 19.12 A O ATOM 8104 N HIS A 511 53.307 −23.088 8.907 1.00 20.18 A N ATOM 8105 CA HIS A 511 54.032 −23.956 9.844 1.00 21.08 A C ATOM 8107 CB HIS A 511 54.180 −25.378 9.276 1.00 20.92 A C ATOM 8110 CG HIS A 511 52.976 −26.246 9.480 1.00 21.15 A C ATOM 8111 ND1 HIS A 511 52.496 −26.574 10.731 1.00 23.07 A N ATOM 8113 CE1 HIS A 511 51.438 −27.355 10.605 1.00 21.16 A C ATOM 8115 NE2 HIS A 511 51.220 −27.555 9.318 1.00 20.02 A N ATOM 8117 CD2 HIS A 511 52.171 −26.877 8.593 1.00 20.33 A C ATOM 8119 C HIS A 511 55.422 −23.394 10.176 1.00 22.01 A C ATOM 8120 O HIS A 511 55.836 −23.382 11.340 1.00 22.10 A O ATOM 8122 N CYS A 512 56.127 −22.928 9.145 1.00 22.75 A N ATOM 8123 CA CYS A 512 57.489 −22.410 9.291 1.00 23.31 A C ATOM 8125 CB CYS A 512 58.162 −22.308 7.918 1.00 23.29 A C ATOM 8128 SG CYS A 512 58.272 −23.878 7.018 1.00 23.12 A S ATOM 8130 C CYS A 512 57.560 −21.048 9.997 1.00 24.05 A C ATOM 8131 O CYS A 512 58.612 −20.683 10.522 1.00 24.32 A O ATOM 8133 N THR A 513 56.455 −20.303 10.006 1.00 24.74 A N ATOM 8134 CA THR A 513 56.424 −18.975 10.627 1.00 25.50 A C ATOM 8136 CB THR A 513 55.556 −17.982 9.806 1.00 25.40 A C ATOM 8138 OG1 THR A 513 56.349 −17.410 8.760 1.00 24.78 A O ATOM 8140 CG2 THR A 513 55.027 −16.856 10.681 1.00 25.88 A C ATOM 8144 C THR A 513 55.948 −19.012 12.082 1.00 26.41 A C ATOM 8145 O THR A 513 56.535 −18.347 12.940 1.00 26.85 A O ATOM 8147 N TYR A 514 54.899 −19.786 12.361 1.00 27.13 A N ATOM 8148 CA TYR A 514 54.304 −19.828 13.703 1.00 27.65 A C ATOM 8150 CB TYR A 514 52.780 −19.915 13.608 1.00 27.23 A C ATOM 8153 CG TYR A 514 52.205 −18.699 12.929 1.00 25.40 A C ATOM 8154 CD1 TYR A 514 52.107 −17.486 13.607 1.00 24.39 A C ATOM 8156 CE1 TYR A 514 51.598 −16.355 12.985 1.00 22.46 A C ATOM 8158 CZ TYR A 514 51.196 −16.428 11.667 1.00 21.99 A C ATOM 8159 OH TYR A 514 50.694 −15.313 11.041 1.00 21.78 A O ATOM 8161 CE2 TYR A 514 51.297 −17.618 10.969 1.00 22.62 A C ATOM 8163 CD2 TYR A 514 51.804 −18.743 11.600 1.00 22.78 A C ATOM 8165 C TYR A 514 54.883 −20.942 14.571 1.00 29.02 A C ATOM 8166 O TYR A 514 54.290 −22.013 14.724 1.00 28.90 A O ATOM 8168 N HIS A 515 56.057 −20.655 15.129 1.00 30.73 A N ATOM 8169 CA HIS A 515 56.761 −21.538 16.063 1.00 32.06 A C ATOM 8171 CB HIS A 515 58.121 −21.948 15.484 1.00 32.40 A C ATOM 8174 CG HIS A 515 59.036 −20.791 15.217 1.00 33.80 A C ATOM 8175 ND1 HIS A 515 59.022 −20.090 14.030 1.00 34.76 A N ATOM 8177 CE1 HIS A 515 59.920 −19.122 14.081 1.00 35.38 A C ATOM 8179 NE2 HIS A 515 60.513 −19.166 15.261 1.00 35.75 A N ATOM 8181 CD2 HIS A 515 59.977 −20.200 15.991 1.00 34.95 A C ATOM 8183 C HIS A 515 56.966 −20.796 17.389 1.00 32.51 A C ATOM 8184 O HIS A 515 56.694 −19.593 17.484 1.00 32.74 A O ATOM 8186 N ASN A 516 57.448 −21.517 18.401 1.00 32.73 A N ATOM 8187 CA ASN A 516 57.747 −20.931 19.713 1.00 32.96 A C ATOM 8189 CB ASN A 516 56.625 −21.237 20.715 1.00 33.20 A C ATOM 8192 CG ASN A 516 55.351 −20.436 20.446 1.00 33.85 A C ATOM 8193 OD1 ASN A 516 54.596 −20.730 19.512 1.00 31.44 A O ATOM 8194 ND2 ASN A 516 55.097 −19.430 21.283 1.00 33.00 A N ATOM 8197 C ASN A 516 59.081 −21.436 20.261 1.00 32.91 A C ATOM 8198 O ASN A 516 60.121 −21.308 19.611 1.00 33.04 A O ATOM 8200 N THR A 521 66.548 −21.132 21.796 1.00 40.70 A N ATOM 8201 CA THR A 521 66.207 −20.050 20.874 1.00 40.78 A C ATOM 8203 CB THR A 521 66.436 −20.476 19.406 1.00 40.62 A C ATOM 8205 OG1 THR A 521 67.703 −21.134 19.285 1.00 39.94 A O ATOM 8207 CG2 THR A 521 66.402 −19.267 18.478 1.00 40.21 A C ATOM 8211 C THR A 521 64.746 −19.619 21.056 1.00 41.19 A C ATOM 8212 O THR A 521 63.841 −20.460 21.049 1.00 41.68 A O ATOM 8214 N SER A 522 64.523 −18.313 21.209 1.00 41.01 A N ATOM 8215 CA SER A 522 63.182 −17.767 21.453 1.00 40.95 A C ATOM 8217 CB SER A 522 63.294 −16.355 22.049 1.00 40.91 A C ATOM 8220 OG SER A 522 63.552 −15.382 21.052 1.00 40.15 A O ATOM 8222 C SER A 522 62.329 −17.754 20.168 1.00 41.29 A C ATOM 8223 O SER A 522 62.835 −18.071 19.089 1.00 41.26 A O ATOM 8225 N PRO A 523 61.026 −17.409 20.282 1.00 41.67 A N ATOM 8226 CA PRO A 523 60.172 −17.283 19.088 1.00 41.68 A C ATOM 8228 CB PRO A 523 58.815 −16.856 19.666 1.00 41.63 A C ATOM 8231 CG PRO A 523 58.807 −17.408 21.044 1.00 41.77 A C ATOM 8234 CD PRO A 523 60.230 −17.359 21.526 1.00 41.83 A C ATOM 8237 C PRO A 523 60.679 −16.274 18.041 1.00 41.69 A C ATOM 8238 O PRO A 523 60.935 −16.665 16.900 1.00 41.96 A O ATOM 8239 N ASP A 524 60.820 −15.003 18.422 1.00 41.43 A N ATOM 8240 CA ASP A 524 61.364 −13.979 17.522 1.00 41.02 A C ATOM 8242 CB ASP A 524 60.602 −12.652 17.664 1.00 41.31 A C ATOM 8245 CG ASP A 524 60.708 −11.774 16.417 1.00 42.01 A C ATOM 8246 OD1 ASP A 524 61.842 −11.469 15.989 1.00 42.29 A O ATOM 8247 OD2 ASP A 524 59.655 −11.387 15.865 1.00 42.57 A O ATOM 8248 C ASP A 524 62.854 −13.803 17.824 1.00 40.28 A C ATOM 8249 O ASP A 524 63.228 −13.154 18.802 1.00 40.11 A O ATOM 8251 N GLU A 525 63.681 −14.371 16.946 1.00 39.60 A N ATOM 8252 CA GLU A 525 65.126 −14.597 17.159 1.00 39.35 A C ATOM 8254 CB GLU A 525 65.483 −14.783 18.645 1.00 39.51 A C ATOM 8257 CG GLU A 525 66.978 −14.944 18.955 1.00 40.12 A C ATOM 8260 CD GLU A 525 67.789 −13.676 18.721 1.00 41.52 A C ATOM 8261 OE1 GLU A 525 69.013 −13.799 18.496 1.00 41.73 A O ATOM 8262 OE2 GLU A 525 67.217 −12.562 18.760 1.00 41.99 A O ATOM 8263 C GLU A 525 65.554 −15.835 16.352 1.00 38.94 A C ATOM 8264 O GLU A 525 66.736 −15.994 16.020 1.00 39.49 A O ATOM 8266 N LEU A 526 64.589 −16.716 16.072 1.00 37.92 A N ATOM 8267 CA LEU A 526 64.740 −17.769 15.068 1.00 36.89 A C ATOM 8269 CB LEU A 526 64.024 −19.049 15.516 1.00 36.77 A C ATOM 8272 CG LEU A 526 64.013 −20.253 14.565 1.00 36.82 A C ATOM 8274 CD1 LEU A 526 63.540 −21.504 15.302 1.00 35.24 A C ATOM 8278 CD2 LEU A 526 65.382 −20.492 13.935 1.00 36.63 A C ATOM 8282 C LEU A 526 64.185 −17.262 13.735 1.00 36.23 A C ATOM 8283 O LEU A 526 64.661 −17.654 12.671 1.00 36.06 A O ATOM 8285 N THR A 527 63.177 −16.391 13.805 1.00 35.70 A N ATOM 8286 CA THR A 527 62.713 −15.630 12.643 1.00 35.26 A C ATOM 8288 CB THR A 527 61.469 −14.766 12.981 1.00 35.09 A C ATOM 8290 OG1 THR A 527 60.448 −15.587 13.560 1.00 35.42 A O ATOM 8292 CG2 THR A 527 60.918 −14.084 11.730 1.00 33.75 A C ATOM 8296 C THR A 527 63.817 −14.705 12.121 1.00 35.05 A C ATOM 8297 O THR A 527 63.915 −14.473 10.914 1.00 35.33 A O ATOM 8299 N ARG A 528 64.645 −14.185 13.029 1.00 34.45 A N ATOM 8300 CA ARG A 528 65.746 −13.295 12.654 1.00 34.07 A C ATOM 8302 CB ARG A 528 66.399 −12.684 13.897 1.00 34.21 A C ATOM 8305 CG ARG A 528 67.430 −11.597 13.577 1.00 35.79 A C ATOM 8308 CD ARG A 528 68.237 −11.153 14.802 1.00 37.39 A C ATOM 8311 NE ARG A 528 68.738 −12.271 15.607 1.00 38.17 A N ATOM 8313 CZ ARG A 528 69.715 −13.105 15.245 1.00 37.53 A C ATOM 8314 NH1 ARG A 528 70.333 −12.981 14.072 1.00 36.61 A N ATOM 8317 NH2 ARG A 528 70.079 −14.085 16.066 1.00 37.93 A N ATOM 8320 C ARG A 528 66.801 −14.024 11.819 1.00 33.31 A C ATOM 8321 O ARG A 528 67.225 −13.525 10.774 1.00 33.25 A O ATOM 8323 N LYS A 529 67.221 −15.198 12.287 1.00 32.35 A N ATOM 8324 CA LYS A 529 68.219 −16.003 11.579 1.00 31.60 A C ATOM 8326 CB LYS A 529 68.676 −17.186 12.439 1.00 31.66 A C ATOM 8329 CG LYS A 529 69.437 −16.800 13.696 1.00 31.41 A C ATOM 8332 CD LYS A 529 69.959 −18.035 14.408 1.00 31.32 A C ATOM 8335 CE LYS A 529 70.798 −17.669 15.617 1.00 32.31 A C ATOM 8338 NZ LYS A 529 71.369 −18.876 16.276 1.00 33.65 A N ATOM 8342 C LYS A 529 67.670 −16.531 10.260 1.00 30.95 A C ATOM 8343 O LYS A 529 68.297 −16.364 9.213 1.00 30.56 A O ATOM 8345 N ARG A 530 66.501 −17.170 10.329 1.00 30.64 A N ATOM 8346 CA ARG A 530 65.846 −17.760 9.153 1.00 30.15 A C ATOM 8348 CB ARG A 530 64.482 −18.362 9.525 1.00 29.94 A C ATOM 8351 CG ARG A 530 64.561 −19.726 10.225 1.00 29.01 A C ATOM 8354 CD ARG A 530 63.171 −20.281 10.550 1.00 27.64 A C ATOM 8357 NE ARG A 530 63.220 −21.609 11.172 1.00 25.77 A N ATOM 8359 CZ ARG A 530 62.150 −22.322 11.537 1.00 23.97 A C ATOM 8360 NH1 ARG A 530 60.921 −21.851 11.352 1.00 22.79 A N ATOM 8363 NH2 ARG A 530 62.307 −23.518 12.092 1.00 23.31 A N ATOM 8366 C ARG A 530 65.689 −16.746 8.017 1.00 30.16 A C ATOM 8367 O ARG A 530 65.923 −17.075 6.853 1.00 30.17 A O ATOM 8369 N VAL A 531 65.304 −15.518 8.360 1.00 30.09 A N ATOM 8370 CA VAL A 531 65.249 −14.423 7.384 1.00 29.85 A C ATOM 8372 CB VAL A 531 64.687 −13.116 8.009 1.00 29.92 A C ATOM 8374 CG1 VAL A 531 65.130 −11.891 7.212 1.00 29.47 A C ATOM 8378 CG2 VAL A 531 63.166 −13.183 8.090 1.00 30.50 A C ATOM 8382 C VAL A 531 66.628 −14.151 6.781 1.00 29.24 A C ATOM 8383 O VAL A 531 66.781 −14.158 5.559 1.00 29.23 A O ATOM 8385 N LEU A 532 67.623 −13.925 7.639 1.00 28.50 A N ATOM 8386 CA LEU A 532 68.994 −13.652 7.186 1.00 28.01 A C ATOM 8388 CB LEU A 532 69.944 −13.450 8.378 1.00 28.09 A C ATOM 8391 CG LEU A 532 70.095 −12.013 8.894 1.00 28.78 A C ATOM 8393 CD1 LEU A 532 68.741 −11.373 9.211 1.00 28.04 A C ATOM 8397 CD2 LEU A 532 71.014 −11.979 10.112 1.00 28.59 A C ATOM 8401 C LEU A 532 69.533 −14.754 6.272 1.00 27.20 A C ATOM 8402 O LEU A 532 70.151 −14.470 5.243 1.00 26.80 A O ATOM 8404 N SER A 533 69.283 −16.004 6.652 1.00 26.36 A N ATOM 8405 CA SER A 533 69.742 −17.159 5.883 1.00 25.65 A C ATOM 8407 CB SER A 533 69.573 −18.437 6.705 1.00 25.79 A C ATOM 8410 OG SER A 533 68.231 −18.588 7.127 1.00 26.13 A O ATOM 8412 C SER A 533 69.009 −17.306 4.549 1.00 24.80 A C ATOM 8413 O SER A 533 69.589 −17.786 3.573 1.00 24.87 A O ATOM 8415 N VAL A 534 67.742 −16.897 4.514 1.00 23.73 A N ATOM 8416 CA VAL A 534 66.930 −16.993 3.299 1.00 22.78 A C ATOM 8418 CB VAL A 534 65.442 −17.279 3.634 1.00 22.62 A C ATOM 8420 CG1 VAL A 534 64.574 −17.176 2.393 1.00 22.83 A C ATOM 8424 CG2 VAL A 534 65.299 −18.661 4.247 1.00 20.75 A C ATOM 8428 C VAL A 534 67.063 −15.751 2.407 1.00 22.04 A C ATOM 8429 O VAL A 534 67.186 −15.880 1.188 1.00 21.64 A O ATOM 8431 N ILE A 535 67.058 −14.562 3.010 1.00 21.46 A N ATOM 8432 CA ILE A 535 67.090 −13.304 2.249 1.00 21.12 A C ATOM 8434 CB ILE A 535 66.130 −12.241 2.845 1.00 21.03 A C ATOM 8436 CG1 ILE A 535 64.702 −12.782 2.954 1.00 19.56 A C ATOM 8439 CD1 ILE A 535 64.055 −13.076 1.628 1.00 18.99 A C ATOM 8443 CG2 ILE A 535 66.138 −10.979 1.990 1.00 20.45 A C ATOM 8447 C ILE A 535 68.488 −12.678 2.122 1.00 21.08 A C ATOM 8448 O ILE A 535 69.043 −12.638 1.025 1.00 21.16 A O ATOM 8450 N THR A 536 69.049 −12.188 3.229 1.00 21.05 A N ATOM 8451 CA THR A 536 70.220 −11.290 3.167 1.00 21.47 A C ATOM 8453 CB THR A 536 70.259 −10.315 4.373 1.00 21.61 A C ATOM 8455 OG1 THR A 536 70.381 −11.053 5.593 1.00 23.10 A O ATOM 8457 CG2 THR A 536 68.993 −9.465 4.422 1.00 22.21 A C ATOM 8461 C THR A 536 71.587 −11.983 3.039 1.00 20.97 A C ATOM 8462 O THR A 536 72.308 −11.747 2.069 1.00 20.73 A O ATOM 8464 N GLU A 537 71.947 −12.817 4.013 1.00 20.65 A N ATOM 8465 CA GLU A 537 73.259 −13.474 4.017 1.00 20.51 A C ATOM 8467 CB GLU A 537 73.649 −13.911 5.432 1.00 20.64 A C ATOM 8470 CG GLU A 537 73.824 −12.751 6.409 1.00 21.25 A C ATOM 8473 CD GLU A 537 74.728 −13.076 7.590 1.00 20.98 A C ATOM 8474 OE1 GLU A 537 74.910 −12.186 8.448 1.00 19.76 A O ATOM 8475 OE2 GLU A 537 75.261 −14.205 7.663 1.00 20.90 A O ATOM 8476 C GLU A 537 73.294 −14.689 3.088 1.00 20.36 A C ATOM 8477 O GLU A 537 72.475 −15.599 3.235 1.00 20.54 A O ATOM 8479 N PRO A 538 74.244 −14.718 2.130 1.00 20.10 A N ATOM 8480 CA PRO A 538 74.398 −15.928 1.321 1.00 19.67 A C ATOM 8482 CB PRO A 538 75.354 −15.495 0.198 1.00 19.39 A C ATOM 8485 CG PRO A 538 75.435 −14.010 0.274 1.00 19.88 A C ATOM 8488 CD PRO A 538 75.155 −13.647 1.688 1.00 20.22 A C ATOM 8491 C PRO A 538 75.009 −17.071 2.123 1.00 19.62 A C ATOM 8492 O PRO A 538 75.449 −16.868 3.256 1.00 19.61 A O ATOM 8493 N ILE A 539 75.027 −18.263 1.534 1.00 19.52 A N ATOM 8494 CA ILE A 539 75.661 −19.422 2.154 1.00 19.35 A C ATOM 8496 CB ILE A 539 75.149 −20.739 1.535 1.00 19.15 A C ATOM 8498 CG1 ILE A 539 73.656 −20.902 1.813 1.00 19.17 A C ATOM 8501 CD1 ILE A 539 73.079 −22.205 1.311 1.00 19.79 A C ATOM 8505 CG2 ILE A 539 75.913 −21.934 2.090 1.00 19.34 A C ATOM 8509 C ILE A 539 77.173 −19.326 1.977 1.00 19.38 A C ATOM 8510 O ILE A 539 77.652 −18.812 0.963 1.00 18.71 A O ATOM 8512 N LEU A 540 77.920 −19.810 2.969 1.00 19.89 A N ATOM 8513 CA LEU A 540 79.379 −19.852 2.876 1.00 20.47 A C ATOM 8515 CB LEU A 540 80.001 −20.467 4.139 1.00 20.46 A C ATOM 8518 CG LEU A 540 79.948 −19.634 5.427 1.00 20.08 A C ATOM 8520 CD1 LEU A 540 80.419 −20.457 6.618 1.00 18.44 A C ATOM 8524 CD2 LEU A 540 80.775 −18.359 5.296 1.00 17.67 A C ATOM 8528 C LEU A 540 79.765 −20.664 1.638 1.00 20.82 A C ATOM 8529 O LEU A 540 79.241 −21.761 1.438 1.00 20.93 A O ATOM 8531 N PRO A 541 80.669 −20.123 0.797 1.00 21.10 A N ATOM 8532 CA PRO A 541 80.960 −20.737 −0.501 1.00 21.17 A C ATOM 8534 CB PRO A 541 81.831 −19.687 −1.197 1.00 20.94 A C ATOM 8537 CG PRO A 541 82.477 −18.951 −0.096 1.00 21.31 A C ATOM 8540 CD PRO A 541 81.484 −18.917 1.024 1.00 21.15 A C ATOM 8543 C PRO A 541 81.692 −22.071 −0.401 1.00 21.47 A C ATOM 8544 O PRO A 541 82.045 −22.508 0.693 1.00 21.43 A O ATOM 8545 N PHE A 542 81.915 −22.701 −1.550 1.00 22.16 A N ATOM 8546 CA PHE A 542 82.488 −24.043 −1.607 1.00 22.83 A C ATOM 8548 CB PHE A 542 82.148 −24.685 −2.953 1.00 22.75 A C ATOM 8551 CG PHE A 542 82.651 −26.095 −3.102 1.00 22.87 A C ATOM 8552 CD1 PHE A 542 83.477 −26.446 −4.163 1.00 22.56 A C ATOM 8554 CE1 PHE A 542 83.938 −27.747 −4.306 1.00 21.48 A C ATOM 8556 CZ PHE A 542 83.581 −28.712 −3.382 1.00 21.47 A C ATOM 8558 CE2 PHE A 542 82.760 −28.376 −2.316 1.00 22.09 A C ATOM 8560 CD2 PHE A 542 82.301 −27.073 −2.180 1.00 22.60 A C ATOM 8562 C PHE A 542 84.007 −24.066 −1.386 1.00 23.60 A C ATOM 8563 O PHE A 542 84.750 −23.309 −2.017 1.00 23.24 A O ATOM 8565 N GLU A 543 84.447 −24.940 −0.480 1.00 24.65 A N ATOM 8566 CA GLU A 543 85.867 −25.238 −0.264 1.00 25.63 A C ATOM 8568 CB GLU A 543 86.242 −25.032 1.209 1.00 25.64 A C ATOM 8571 CG GLU A 543 86.531 −23.587 1.593 1.00 25.04 A C ATOM 8574 CD GLU A 543 87.219 −23.462 2.945 1.00 24.31 A C ATOM 8575 OE1 GLU A 543 87.195 −24.433 3.733 1.00 23.03 A O ATOM 8576 OE2 GLU A 543 87.787 −22.385 3.219 1.00 23.80 A O ATOM 8577 C GLU A 543 86.149 −26.685 −0.685 1.00 26.60 A C ATOM 8578 O GLU A 543 85.244 −27.387 −1.132 1.00 26.93 A O ATOM 8580 N ARG A 544 87.398 −27.128 −0.543 1.00 27.49 A N ATOM 8581 CA ARG A 544 87.790 −28.496 −0.904 1.00 28.18 A C ATOM 8583 CB ARG A 544 88.462 −28.503 −2.283 1.00 28.70 A C ATOM 8586 CG ARG A 544 87.480 −28.538 −3.454 1.00 30.13 A C ATOM 8589 CD ARG A 544 87.958 −27.689 −4.627 1.00 32.27 A C ATOM 8592 NE ARG A 544 87.029 −27.745 −5.758 1.00 34.04 A N ATOM 8594 CZ ARG A 544 86.969 −26.853 −6.749 1.00 35.15 A C ATOM 8595 NH1 ARG A 544 87.785 −25.801 −6.780 1.00 35.93 A N ATOM 8598 NH2 ARG A 544 86.078 −27.010 −7.722 1.00 35.60 A N ATOM 8601 C ARG A 544 88.718 −29.113 0.148 1.00 28.07 A C ATOM 8602 O ARG A 544 89.936 −28.927 0.113 1.00 27.79 A O ATOM 8604 N SER B 6 65.194 37.534 11.490 1.00 30.93 B N ATOM 8605 CA SER B 6 66.501 38.213 11.258 1.00 31.10 B C ATOM 8607 CB SER B 6 67.126 38.622 12.599 1.00 31.12 B C ATOM 8610 OG SER B 6 68.384 39.251 12.418 1.00 30.48 B O ATOM 8612 C SER B 6 67.433 37.305 10.437 1.00 31.29 B C ATOM 8613 O SER B 6 67.056 36.867 9.347 1.00 31.44 B O ATOM 8617 N ALA B 7 68.634 37.031 10.954 1.00 31.29 B N ATOM 8618 CA ALA B 7 69.633 36.190 10.276 1.00 31.27 B C ATOM 8620 CB ALA B 7 70.875 36.063 11.153 1.00 31.07 B C ATOM 8624 C ALA B 7 69.128 34.792 9.894 1.00 31.29 B C ATOM 8625 O ALA B 7 68.262 34.227 10.566 1.00 31.47 B O ATOM 8627 N ASN B 8 69.690 34.242 8.817 1.00 31.13 B N ATOM 8628 CA ASN B 8 69.342 32.903 8.333 1.00 30.87 B C ATOM 8630 CB ASN B 8 68.536 33.009 7.033 1.00 30.78 B C ATOM 8633 CG ASN B 8 68.152 31.652 6.460 1.00 30.33 B C ATOM 8634 OD1 ASN B 8 67.997 30.671 7.187 1.00 30.31 B O ATOM 8635 ND2 ASN B 8 67.988 31.597 5.144 1.00 29.92 B N ATOM 8638 C ASN B 8 70.591 32.048 8.110 1.00 30.77 B C ATOM 8639 O ASN B 8 71.467 32.411 7.324 1.00 30.68 B O ATOM 8641 N TYR B 9 70.659 30.915 8.808 1.00 30.85 B N ATOM 8642 CA TYR B 9 71.782 29.980 8.700 1.00 30.90 B C ATOM 8644 CB TYR B 9 72.394 29.745 10.081 1.00 30.91 B C ATOM 8647 CG TYR B 9 72.941 30.996 10.724 1.00 31.38 B C ATOM 8648 CD1 TYR B 9 74.066 31.627 10.207 1.00 31.49 B C ATOM 8650 CE1 TYR B 9 74.577 32.772 10.792 1.00 31.53 B C ATOM 8652 CZ TYR B 9 73.963 33.302 11.915 1.00 31.18 B C ATOM 8653 OH TYR B 9 74.464 34.440 12.505 1.00 31.64 B O ATOM 8655 CE2 TYR B 9 72.845 32.694 12.449 1.00 30.98 B C ATOM 8657 CD2 TYR B 9 72.340 31.545 11.853 1.00 31.50 B C ATOM 8659 C TYR B 9 71.392 28.628 8.099 1.00 30.89 B C ATOM 8660 O TYR B 9 72.244 27.749 7.954 1.00 30.84 B O ATOM 8662 N GLU B 10 70.118 28.461 7.748 1.00 30.91 B N ATOM 8663 CA GLU B 10 69.619 27.177 7.254 1.00 30.96 B C ATOM 8665 CB GLU B 10 68.090 27.193 7.135 1.00 31.16 B C ATOM 8668 CG GLU B 10 67.357 27.168 8.477 1.00 32.67 B C ATOM 8671 CD GLU B 10 65.997 26.478 8.404 1.00 34.80 B C ATOM 8672 OE1 GLU B 10 65.359 26.497 7.327 1.00 35.78 B O ATOM 8673 OE2 GLU B 10 65.564 25.914 9.433 1.00 34.93 B O ATOM 8674 C GLU B 10 70.237 26.801 5.905 1.00 30.57 B C ATOM 8675 O GLU B 10 70.673 27.678 5.156 1.00 30.27 B O ATOM 8677 N PRO B 11 70.281 25.490 5.596 1.00 30.23 B N ATOM 8678 CA PRO B 11 70.814 25.038 4.314 1.00 29.93 B C ATOM 8680 CB PRO B 11 70.985 23.528 4.519 1.00 29.85 B C ATOM 8683 CG PRO B 11 69.977 23.171 5.533 1.00 29.86 B C ATOM 8686 CD PRO B 11 69.874 24.357 6.448 1.00 30.23 B C ATOM 8689 C PRO B 11 69.862 25.312 3.154 1.00 29.66 B C ATOM 8690 O PRO B 11 68.641 25.250 3.325 1.00 29.68 B O ATOM 8691 N ASN B 12 70.428 25.631 1.993 1.00 29.25 B N ATOM 8692 CA ASN B 12 69.672 25.660 0.747 1.00 28.94 B C ATOM 8694 CB ASN B 12 70.298 26.638 −0.252 1.00 29.10 B C ATOM 8697 CG ASN B 12 70.210 28.086 0.208 1.00 29.53 B C ATOM 8698 OD1 ASN B 12 69.136 28.575 0.559 1.00 31.39 B O ATOM 8699 ND2 ASN B 12 71.342 28.782 0.196 1.00 28.62 B N ATOM 8702 C ASN B 12 69.646 24.253 0.162 1.00 28.62 B C ATOM 8703 O ASN B 12 70.554 23.458 0.409 1.00 28.75 B O ATOM 8705 N SER B 13 68.600 23.943 −0.600 1.00 28.28 B N ATOM 8706 CA SER B 13 68.467 22.629 −1.238 1.00 27.84 B C ATOM 8708 CB SER B 13 67.066 22.466 −1.842 1.00 27.87 B C ATOM 8711 OG SER B 13 66.698 23.594 −2.621 1.00 27.68 B O ATOM 8713 C SER B 13 69.540 22.403 −2.312 1.00 27.33 B C ATOM 8714 O SER B 13 69.999 21.280 −2.514 1.00 27.15 B O ATOM 8716 N TRP B 14 69.941 23.480 −2.982 1.00 26.98 B N ATOM 8717 CA TRP B 14 70.947 23.410 −4.047 1.00 27.01 B C ATOM 8719 CB TRP B 14 70.801 24.595 −5.025 1.00 27.03 B C ATOM 8722 CG TRP B 14 70.521 25.947 −4.396 1.00 27.01 B C ATOM 8723 CD1 TRP B 14 69.295 26.521 −4.199 1.00 27.14 B C ATOM 8725 NE1 TRP B 14 69.435 27.754 −3.612 1.00 26.54 B N ATOM 8727 CE2 TRP B 14 70.768 28.009 −3.426 1.00 27.41 B C ATOM 8728 CD2 TRP B 14 71.485 26.892 −3.911 1.00 27.68 B C ATOM 8729 CE3 TRP B 14 72.884 26.902 −3.834 1.00 29.36 B C ATOM 8731 CZ3 TRP B 14 73.516 28.014 −3.281 1.00 30.23 B C ATOM 8733 CH2 TRP B 14 72.773 29.109 −2.808 1.00 29.91 B C ATOM 8735 CZ2 TRP B 14 71.402 29.125 −2.873 1.00 28.79 B C ATOM 8737 C TRP B 14 72.402 23.306 −3.548 1.00 27.02 B C ATOM 8738 O TRP B 14 73.290 22.935 −4.320 1.00 26.74 B O ATOM 8740 N ASP B 15 72.638 23.614 −2.270 1.00 26.93 B N ATOM 8741 CA ASP B 15 73.999 23.688 −1.705 1.00 26.86 B C ATOM 8743 CB ASP B 15 73.944 23.887 −0.182 1.00 26.86 B C ATOM 8746 CG ASP B 15 73.721 25.336 0.219 1.00 26.99 B C ATOM 8747 OD1 ASP B 15 73.870 26.238 −0.637 1.00 24.43 B O ATOM 8748 OD2 ASP B 15 73.406 25.571 1.408 1.00 27.44 B O ATOM 8749 C ASP B 15 74.894 22.484 −2.010 1.00 26.90 B C ATOM 8750 O ASP B 15 74.415 21.365 −2.191 1.00 26.83 B O ATOM 8752 N TYR B 16 76.202 22.739 −2.039 1.00 27.18 B N ATOM 8753 CA TYR B 16 77.202 21.717 −2.361 1.00 27.47 B C ATOM 8755 CB TYR B 16 78.530 22.369 −2.767 1.00 27.32 B C ATOM 8758 CG TYR B 16 78.492 23.077 −4.106 1.00 25.78 B C ATOM 8759 CD1 TYR B 16 78.255 22.372 −5.283 1.00 24.46 B C ATOM 8761 CE1 TYR B 16 78.223 23.015 −6.512 1.00 23.58 B C ATOM 8763 CZ TYR B 16 78.436 24.378 −6.576 1.00 23.84 B C ATOM 8764 OH TYR B 16 78.405 25.020 −7.792 1.00 23.45 B O ATOM 8766 CE2 TYR B 16 78.679 25.100 −5.422 1.00 24.10 B C ATOM 8768 CD2 TYR B 16 78.707 24.446 −4.197 1.00 24.90 B C ATOM 8770 C TYR B 16 77.449 20.724 −1.219 1.00 28.17 B C ATOM 8771 O TYR B 16 77.971 19.635 −1.455 1.00 28.00 B O ATOM 8773 N ASP B 17 77.100 21.103 0.009 1.00 28.94 B N ATOM 8774 CA ASP B 17 77.182 20.189 1.153 1.00 29.33 B C ATOM 8776 CB ASP B 17 77.135 20.960 2.479 1.00 29.08 B C ATOM 8779 CG ASP B 17 78.279 21.954 2.627 1.00 28.02 B C ATOM 8780 OD1 ASP B 17 78.883 22.334 1.602 1.00 26.84 B O ATOM 8781 OD2 ASP B 17 78.570 22.364 3.770 1.00 26.76 B O ATOM 8782 C ASP B 17 76.026 19.188 1.087 1.00 30.23 B C ATOM 8783 O ASP B 17 76.202 17.997 1.355 1.00 30.34 B O ATOM 8785 N TYR B 18 74.847 19.697 0.728 1.00 31.12 B N ATOM 8786 CA TYR B 18 73.640 18.888 0.552 1.00 32.00 B C ATOM 8788 CB TYR B 18 72.432 19.814 0.349 1.00 32.50 B C ATOM 8791 CG TYR B 18 71.072 19.146 0.372 1.00 34.76 B C ATOM 8792 CD1 TYR B 18 70.211 19.321 1.455 1.00 37.40 B C ATOM 8794 CE1 TYR B 18 68.955 18.727 1.479 1.00 38.40 B C ATOM 8796 CZ TYR B 18 68.545 17.952 0.408 1.00 38.58 B C ATOM 8797 OH TYR B 18 67.302 17.361 0.428 1.00 39.64 B O ATOM 8799 CE2 TYR B 18 69.378 17.770 −0.683 1.00 37.47 B C ATOM 8801 CD2 TYR B 18 70.631 18.369 −0.698 1.00 35.94 B C ATOM 8803 C TYR B 18 73.821 17.938 −0.634 1.00 32.06 B C ATOM 8804 O TYR B 18 73.879 16.722 −0.447 1.00 32.28 B O ATOM 8806 N LEU B 19 73.916 18.495 −1.844 1.00 31.97 B N ATOM 8807 CA LEU B 19 74.291 17.725 −3.033 1.00 31.81 B C ATOM 8809 CB LEU B 19 74.101 18.552 −4.310 1.00 31.61 B C ATOM 8812 CG LEU B 19 72.673 18.884 −4.747 1.00 31.60 B C ATOM 8814 CD1 LEU B 19 72.676 20.011 −5.771 1.00 29.70 B C ATOM 8818 CD2 LEU B 19 71.975 17.650 −5.307 1.00 32.90 B C ATOM 8822 C LEU B 19 75.755 17.334 −2.900 1.00 32.11 B C ATOM 8823 O LEU B 19 76.478 17.920 −2.100 1.00 32.07 B O ATOM 8825 N LEU B 20 76.188 16.346 −3.679 1.00 32.38 B N ATOM 8826 CA LEU B 20 77.580 15.881 −3.655 1.00 32.60 B C ATOM 8828 CB LEU B 20 78.543 17.016 −4.048 1.00 32.67 B C ATOM 8831 CG LEU B 20 78.184 17.857 −5.275 1.00 32.36 B C ATOM 8833 CD1 LEU B 20 79.247 18.915 −5.510 1.00 31.31 B C ATOM 8837 CD2 LEU B 20 78.023 16.976 −6.502 1.00 32.73 B C ATOM 8841 C LEU B 20 77.976 15.298 −2.289 1.00 32.78 B C ATOM 8842 O LEU B 20 78.727 15.917 −1.531 1.00 32.45 B O ATOM 8844 N SER B 21 77.462 14.108 −1.984 1.00 33.27 B N ATOM 8845 CA SER B 21 77.803 13.407 −0.740 1.00 33.68 B C ATOM 8847 CB SER B 21 76.696 13.592 0.307 1.00 33.73 B C ATOM 8850 OG SER B 21 75.453 13.090 −0.153 1.00 33.56 B O ATOM 8852 C SER B 21 78.067 11.916 −0.981 1.00 33.90 B C ATOM 8853 O SER B 21 77.611 11.344 −1.976 1.00 33.89 B O ATOM 8855 N SER B 22 78.813 11.303 −0.063 1.00 34.06 B N ATOM 8856 CA SER B 22 79.177 9.888 −0.163 1.00 34.19 B C ATOM 8858 CB SER B 22 80.431 9.720 −1.026 1.00 34.22 B C ATOM 8861 OG SER B 22 81.500 10.512 −0.537 1.00 34.16 B O ATOM 8863 C SER B 22 79.417 9.282 1.218 1.00 34.24 B C ATOM 8864 O SER B 22 78.552 8.598 1.766 1.00 34.40 B O ATOM 8866 N ILE B 28 83.096 12.126 −5.219 1.00 33.03 B N ATOM 8867 CA ILE B 28 82.293 13.341 −5.130 1.00 33.17 B C ATOM 8869 CB ILE B 28 80.768 13.019 −5.067 1.00 33.49 B C ATOM 8871 CG1 ILE B 28 80.431 11.736 −5.840 1.00 33.77 B C ATOM 8874 CD1 ILE B 28 78.942 11.415 −5.876 1.00 33.05 B C ATOM 8878 CG2 ILE B 28 79.953 14.191 −5.610 1.00 33.81 B C ATOM 8882 C ILE B 28 82.693 14.165 −3.897 1.00 33.01 B C ATOM 8883 O ILE B 28 81.856 14.845 −3.299 1.00 33.03 B O ATOM 8885 N GLU B 29 83.977 14.116 −3.537 1.00 32.83 B N ATOM 8886 CA GLU B 29 84.462 14.714 −2.288 1.00 32.67 B C ATOM 8888 CB GLU B 29 85.136 13.647 −1.429 1.00 32.76 B C ATOM 8891 CG GLU B 29 84.198 12.510 −1.051 1.00 33.72 B C ATOM 8894 CD GLU B 29 84.786 11.574 −0.012 1.00 35.62 B C ATOM 8895 OE1 GLU B 29 85.447 12.061 0.932 1.00 37.99 B O ATOM 8896 OE2 GLU B 29 84.579 10.348 −0.136 1.00 35.42 B O ATOM 8897 C GLU B 29 85.407 15.895 −2.516 1.00 32.29 B C ATOM 8898 O GLU B 29 85.093 17.019 −2.125 1.00 32.51 B O ATOM 8900 N VAL B 30 86.559 15.650 −3.138 1.00 31.62 B N ATOM 8901 CA VAL B 30 87.465 16.741 −3.525 1.00 30.85 B C ATOM 8903 CB VAL B 30 88.830 16.207 −4.027 1.00 30.72 B C ATOM 8905 CG1 VAL B 30 89.708 17.345 −4.528 1.00 30.15 B C ATOM 8909 CG2 VAL B 30 89.538 15.439 −2.917 1.00 30.01 B C ATOM 8913 C VAL B 30 86.787 17.605 −4.600 1.00 30.37 B C ATOM 8914 O VAL B 30 87.082 18.791 −4.739 1.00 30.28 B O ATOM 8916 N TYR B 31 85.877 16.984 −5.346 1.00 29.78 B N ATOM 8917 CA TYR B 31 84.969 17.674 −6.262 1.00 29.51 B C ATOM 8919 CB TYR B 31 84.111 16.625 −6.984 1.00 29.72 B C ATOM 8922 CG TYR B 31 83.435 17.063 −8.268 1.00 30.61 B C ATOM 8923 CD1 TYR B 31 84.175 17.308 −9.424 1.00 30.75 B C ATOM 8925 CE1 TYR B 31 83.548 17.683 −10.614 1.00 31.57 B C ATOM 8927 CZ TYR B 31 82.163 17.800 −10.655 1.00 31.88 B C ATOM 8928 OH TYR B 31 81.530 18.173 −11.822 1.00 30.54 B O ATOM 8930 CE2 TYR B 31 81.409 17.546 −9.524 1.00 31.66 B C ATOM 8932 CD2 TYR B 31 82.045 17.173 −8.342 1.00 32.07 B C ATOM 8934 C TYR B 31 84.076 18.654 −5.490 1.00 28.96 B C ATOM 8935 O TYR B 31 83.852 19.780 −5.933 1.00 29.21 B O ATOM 8937 N LYS B 32 83.574 18.211 −4.336 1.00 28.11 B N ATOM 8938 CA LYS B 32 82.742 19.037 −3.446 1.00 27.18 B C ATOM 8940 CB LYS B 32 82.091 18.152 −2.368 1.00 27.40 B C ATOM 8943 CG LYS B 32 81.289 18.888 −1.291 1.00 27.70 B C ATOM 8946 CD LYS B 32 81.011 17.982 −0.088 1.00 28.13 B C ATOM 8949 CE LYS B 32 82.214 17.904 0.859 1.00 27.91 B C ATOM 8952 NZ LYS B 32 82.132 16.766 1.823 1.00 26.03 B N ATOM 8956 C LYS B 32 83.549 20.159 −2.788 1.00 26.03 B C ATOM 8957 O LYS B 32 83.099 21.305 −2.740 1.00 25.99 B O ATOM 8959 N ASP B 33 84.731 19.820 −2.274 1.00 24.80 B N ATOM 8960 CA ASP B 33 85.635 20.807 −1.666 1.00 23.80 B C ATOM 8962 CB ASP B 33 86.882 20.123 −1.073 1.00 23.97 B C ATOM 8965 CG ASP B 33 86.603 19.412 0.252 1.00 23.84 B C ATOM 8966 OD1 ASP B 33 85.444 19.021 0.506 1.00 24.89 B O ATOM 8967 OD2 ASP B 33 87.557 19.238 1.041 1.00 21.93 B O ATOM 8968 C ASP B 33 86.074 21.887 −2.664 1.00 22.53 B C ATOM 8969 O ASP B 33 86.377 23.012 −2.270 1.00 22.50 B O ATOM 8971 N LYS B 34 86.111 21.537 −3.949 1.00 21.23 B N ATOM 8972 CA LYS B 34 86.498 22.479 −4.999 1.00 20.16 B C ATOM 8974 CB LYS B 34 86.832 21.737 −6.302 1.00 20.17 B C ATOM 8977 CG LYS B 34 88.013 22.319 −7.068 1.00 21.10 B C ATOM 8980 CD LYS B 34 89.338 21.743 −6.567 1.00 22.05 B C ATOM 8983 CE LYS B 34 90.538 22.487 −7.142 1.00 22.40 B C ATOM 8986 NZ LYS B 34 90.519 22.547 −8.633 1.00 22.69 B N ATOM 8990 C LYS B 34 85.379 23.488 −5.250 1.00 19.08 B C ATOM 8991 O LYS B 34 85.622 24.695 −5.277 1.00 19.11 B O ATOM 8993 N ALA B 35 84.158 22.979 −5.424 1.00 17.76 B N ATOM 8994 CA ALA B 35 82.980 23.805 −5.718 1.00 16.41 B C ATOM 8996 CB ALA B 35 81.743 22.927 −5.847 1.00 16.25 B C ATOM 9000 C ALA B 35 82.745 24.878 −4.663 1.00 15.50 B C ATOM 9001 O ALA B 35 82.464 26.028 −4.996 1.00 15.11 B O ATOM 9003 N LYS B 36 82.857 24.491 −3.395 1.00 14.95 B N ATOM 9004 CA LYS B 36 82.725 25.426 −2.277 1.00 14.49 B C ATOM 9006 CB LYS B 36 82.866 24.686 −0.941 1.00 14.64 B C ATOM 9009 CG LYS B 36 81.721 23.724 −0.624 1.00 14.95 B C ATOM 9012 CD LYS B 36 82.093 22.732 0.482 1.00 14.25 B C ATOM 9015 CE LYS B 36 82.334 23.418 1.820 1.00 12.69 B C ATOM 9018 NZ LYS B 36 82.523 22.434 2.916 1.00 10.99 B N ATOM 9022 C LYS B 36 83.768 26.541 −2.352 1.00 13.97 B C ATOM 9023 O LYS B 36 83.450 27.709 −2.129 1.00 13.72 B O ATOM 9025 N LYS B 37 85.007 26.169 −2.673 1.00 13.59 B N ATOM 9026 CA LYS B 37 86.120 27.119 −2.735 1.00 13.44 B C ATOM 9028 CB LYS B 37 87.457 26.374 −2.816 1.00 13.67 B C ATOM 9031 CG LYS B 37 88.681 27.282 −2.729 1.00 15.27 B C ATOM 9034 CD LYS B 37 89.950 26.502 −2.393 1.00 17.27 B C ATOM 9037 CE LYS B 37 91.135 27.436 −2.137 1.00 17.81 B C ATOM 9040 NZ LYS B 37 91.454 28.302 −3.312 1.00 17.07 B N ATOM 9044 C LYS B 37 86.000 28.100 −3.902 1.00 12.83 B C ATOM 9045 O LYS B 37 86.455 29.241 −3.800 1.00 12.97 B O ATOM 9047 N LEU B 38 85.398 27.655 −5.003 1.00 12.14 B N ATOM 9048 CA LEU B 38 85.198 28.508 −6.176 1.00 11.43 B C ATOM 9050 CB LEU B 38 85.176 27.669 −7.458 1.00 11.06 B C ATOM 9053 CG LEU B 38 86.459 26.883 −7.758 1.00 9.62 B C ATOM 9055 CD1 LEU B 38 86.310 26.057 −9.026 1.00 6.76 B C ATOM 9059 CD2 LEU B 38 87.657 27.812 −7.867 1.00 9.21 B C ATOM 9063 C LEU B 38 83.922 29.348 −6.052 1.00 11.28 B C ATOM 9064 O LEU B 38 83.926 30.532 −6.388 1.00 11.03 B O ATOM 9066 N GLU B 39 82.839 28.738 −5.570 1.00 11.37 B N ATOM 9067 CA GLU B 39 81.605 29.472 −5.271 1.00 11.49 B C ATOM 9069 CB GLU B 39 80.544 28.551 −4.657 1.00 11.84 B C ATOM 9072 CG GLU B 39 79.181 29.229 −4.440 1.00 12.44 B C ATOM 9075 CD GLU B 39 78.197 28.388 −3.639 1.00 13.61 B C ATOM 9076 OE1 GLU B 39 78.576 27.309 −3.140 1.00 14.31 B O ATOM 9077 OE2 GLU B 39 77.033 28.818 −3.504 1.00 13.97 B O ATOM 9078 C GLU B 39 81.891 30.611 −4.305 1.00 11.45 B C ATOM 9079 O GLU B 39 81.370 31.716 −4.466 1.00 11.54 B O ATOM 9081 N ALA B 40 82.714 30.325 −3.298 1.00 11.50 B N ATOM 9082 CA ALA B 40 83.120 31.321 −2.312 1.00 11.48 B C ATOM 9084 CB ALA B 40 84.038 30.689 −1.278 1.00 11.52 B C ATOM 9088 C ALA B 40 83.815 32.506 −2.972 1.00 11.57 B C ATOM 9089 O ALA B 40 83.515 33.661 −2.665 1.00 11.32 B O ATOM 9091 N GLU B 41 84.734 32.210 −3.886 1.00 11.81 B N ATOM 9092 CA GLU B 41 85.501 33.244 −4.580 1.00 12.06 B C ATOM 9094 CB GLU B 41 86.602 32.610 −5.437 1.00 12.41 B C ATOM 9097 CG GLU B 41 87.698 33.583 −5.862 1.00 13.10 B C ATOM 9100 CD GLU B 41 88.924 32.889 −6.430 1.00 13.35 B C ATOM 9101 OE1 GLU B 41 89.231 31.755 −6.004 1.00 13.61 B O ATOM 9102 OE2 GLU B 41 89.589 33.486 −7.301 1.00 13.54 B O ATOM 9103 C GLU B 41 84.596 34.128 −5.436 1.00 11.69 B C ATOM 9104 O GLU B 41 84.749 35.346 −5.452 1.00 11.44 B O ATOM 9106 N VAL B 42 83.651 33.509 −6.135 1.00 11.70 B N ATOM 9107 CA VAL B 42 82.672 34.251 −6.922 1.00 11.83 B C ATOM 9109 CB VAL B 42 81.728 33.305 −7.695 1.00 11.85 B C ATOM 9111 CG1 VAL B 42 80.650 34.095 −8.419 1.00 12.24 B C ATOM 9115 CG2 VAL B 42 82.513 32.460 −8.682 1.00 11.42 B C ATOM 9119 C VAL B 42 81.849 35.162 −6.015 1.00 12.05 B C ATOM 9120 O VAL B 42 81.692 36.348 −6.299 1.00 11.93 B O ATOM 9122 N ARG B 43 81.343 34.602 −4.918 1.00 12.55 B N ATOM 9123 CA ARG B 43 80.539 35.356 −3.949 1.00 13.01 B C ATOM 9125 CB ARG B 43 80.173 34.467 −2.748 1.00 13.46 B C ATOM 9128 CG ARG B 43 79.342 35.153 −1.654 1.00 14.25 B C ATOM 9131 CD ARG B 43 80.220 35.887 −0.635 1.00 14.13 B C ATOM 9134 NE ARG B 43 79.457 36.448 0.477 1.00 13.56 B N ATOM 9136 CZ ARG B 43 79.951 37.291 1.382 1.00 13.26 B C ATOM 9137 NH1 ARG B 43 79.172 37.747 2.356 1.00 13.32 B N ATOM 9140 NH2 ARG B 43 81.218 37.687 1.319 1.00 13.61 B N ATOM 9143 C ARG B 43 81.251 36.623 −3.474 1.00 12.51 B C ATOM 9144 O ARG B 43 80.632 37.683 −3.361 1.00 12.05 B O ATOM 9146 N ARG B 44 82.545 36.504 −3.187 1.00 12.38 B N ATOM 9147 CA ARG B 44 83.347 37.648 −2.750 1.00 12.46 B C ATOM 9149 CB ARG B 44 84.807 37.236 −2.537 1.00 12.38 B C ATOM 9152 CG ARG B 44 85.734 38.380 −2.138 1.00 11.90 B C ATOM 9155 CD ARG B 44 87.112 37.874 −1.750 1.00 10.93 B C ATOM 9158 NE ARG B 44 87.798 37.229 −2.866 1.00 10.06 B N ATOM 9160 CZ ARG B 44 89.003 36.667 −2.788 1.00 10.80 B C ATOM 9161 NH1 ARG B 44 89.679 36.664 −1.643 1.00 12.55 B N ATOM 9164 NH2 ARG B 44 89.539 36.103 −3.863 1.00 10.95 B N ATOM 9167 C ARG B 44 83.278 38.788 −3.758 1.00 12.62 B C ATOM 9168 O ARG B 44 83.176 39.953 −3.375 1.00 12.54 B O ATOM 9170 N GLU B 45 83.332 38.446 −5.042 1.00 12.86 B N ATOM 9171 CA GLU B 45 83.303 39.448 −6.102 1.00 13.14 B C ATOM 9173 CB GLU B 45 83.716 38.840 −7.449 1.00 13.40 B C ATOM 9176 CG GLU B 45 85.094 38.176 −7.467 1.00 13.15 B C ATOM 9179 CD GLU B 45 86.197 39.066 −6.930 1.00 12.52 B C ATOM 9180 OE1 GLU B 45 86.171 40.286 −7.197 1.00 11.65 B O ATOM 9181 OE2 GLU B 45 87.094 38.542 −6.239 1.00 13.46 B O ATOM 9182 C GLU B 45 81.930 40.100 −6.227 1.00 13.07 B C ATOM 9183 O GLU B 45 81.837 41.308 −6.424 1.00 13.24 B O ATOM 9185 N ILE B 46 80.870 39.308 −6.100 1.00 13.28 B N ATOM 9186 CA ILE B 46 79.505 39.831 −6.217 1.00 13.40 B C ATOM 9188 CB ILE B 46 78.450 38.696 −6.262 1.00 13.25 B C ATOM 9190 CG1 ILE B 46 78.670 37.801 −7.485 1.00 12.31 B C ATOM 9193 CD1 ILE B 46 77.743 36.617 −7.546 1.00 11.98 B C ATOM 9197 CG2 ILE B 46 77.044 39.270 −6.318 1.00 12.44 B C ATOM 9201 C ILE B 46 79.179 40.805 −5.078 1.00 13.95 B C ATOM 9202 O ILE B 46 78.401 41.740 −5.269 1.00 13.95 B O ATOM 9204 N ASN B 47 79.788 40.589 −3.910 1.00 14.71 B N ATOM 9205 CA ASN B 47 79.621 41.476 −2.750 1.00 15.06 B C ATOM 9207 CB ASN B 47 79.428 40.644 −1.485 1.00 14.81 B C ATOM 9210 CG ASN B 47 78.236 39.728 −1.579 1.00 15.52 B C ATOM 9211 OD1 ASN B 47 77.091 40.181 −1.600 1.00 15.77 B O ATOM 9212 ND2 ASN B 47 78.495 38.429 −1.650 1.00 17.54 B N ATOM 9215 C ASN B 47 80.779 42.460 −2.552 1.00 15.58 B C ATOM 9216 O ASN B 47 80.888 43.093 −1.498 1.00 16.00 B O ATOM 9218 N ASN B 48 81.637 42.584 −3.563 1.00 15.89 B N ATOM 9219 CA ASN B 48 82.745 43.532 −3.535 1.00 16.06 B C ATOM 9221 CB ASN B 48 83.744 43.202 −4.650 1.00 15.90 B C ATOM 9224 CG ASN B 48 84.925 44.150 −4.685 1.00 15.28 B C ATOM 9225 OD1 ASN B 48 85.262 44.783 −3.686 1.00 15.43 B O ATOM 9226 ND2 ASN B 48 85.566 44.248 −5.843 1.00 15.13 B N ATOM 9229 C ASN B 48 82.214 44.951 −3.701 1.00 16.79 B C ATOM 9230 O ASN B 48 81.838 45.349 −4.806 1.00 17.02 B O ATOM 9232 N GLU B 49 82.188 45.710 −2.606 1.00 17.49 B N ATOM 9233 CA GLU B 49 81.592 47.053 −2.612 1.00 18.37 B C ATOM 9235 CB GLU B 49 81.183 47.467 −1.191 1.00 18.78 B C ATOM 9238 CG GLU B 49 80.125 46.546 −0.564 1.00 20.96 B C ATOM 9241 CD GLU B 49 79.341 47.187 0.583 1.00 23.15 B C ATOM 9242 OE1 GLU B 49 78.832 46.437 1.443 1.00 23.41 B O ATOM 9243 OE2 GLU B 49 79.220 48.432 0.626 1.00 25.12 B O ATOM 9244 C GLU B 49 82.484 48.132 −3.245 1.00 18.48 B C ATOM 9245 O GLU B 49 82.045 49.270 −3.411 1.00 18.18 B O ATOM 9247 N LYS B 50 83.721 47.776 −3.598 1.00 18.96 B N ATOM 9248 CA LYS B 50 84.643 48.694 −4.277 1.00 19.36 B C ATOM 9250 CB LYS B 50 86.002 48.704 −3.569 1.00 19.39 B C ATOM 9253 CG LYS B 50 85.938 48.749 −2.054 1.00 19.24 B C ATOM 9256 CD LYS B 50 87.314 49.008 −1.455 1.00 19.55 B C ATOM 9259 CE LYS B 50 87.442 48.400 −0.069 1.00 19.73 B C ATOM 9262 NZ LYS B 50 86.280 48.740 0.792 1.00 18.94 B N ATOM 9266 C LYS B 50 84.855 48.325 −5.751 1.00 19.85 B C ATOM 9267 O LYS B 50 85.860 48.711 −6.350 1.00 19.64 B O ATOM 9269 N ALA B 51 83.914 47.585 −6.335 1.00 20.78 B N ATOM 9270 CA ALA B 51 84.036 47.130 −7.721 1.00 21.39 B C ATOM 9272 CB ALA B 51 83.225 45.860 −7.932 1.00 21.43 B C ATOM 9276 C ALA B 51 83.580 48.213 −8.693 1.00 21.95 B C ATOM 9277 O ALA B 51 82.643 48.956 −8.402 1.00 21.95 B O ATOM 9279 N GLU B 52 84.248 48.298 −9.842 1.00 22.93 B N ATOM 9280 CA GLU B 52 83.864 49.240 −10.899 1.00 23.64 B C ATOM 9282 CB GLU B 52 84.892 49.243 −12.037 1.00 23.82 B C ATOM 9285 CG GLU B 52 86.280 49.747 −11.642 1.00 24.65 B C ATOM 9288 CD GLU B 52 86.415 51.257 −11.745 1.00 26.37 B C ATOM 9289 OE1 GLU B 52 86.465 51.778 −12.880 1.00 27.93 B O ATOM 9290 OE2 GLU B 52 86.486 51.924 −10.691 1.00 27.36 B O ATOM 9291 C GLU B 52 82.498 48.824 −11.427 1.00 23.98 B C ATOM 9292 O GLU B 52 82.289 47.653 −11.752 1.00 24.25 B O ATOM 9294 N PHE B 53 81.575 49.780 −11.505 1.00 24.11 B N ATOM 9295 CA PHE B 53 80.165 49.475 −11.772 1.00 24.15 B C ATOM 9297 CB PHE B 53 79.315 50.749 −11.715 1.00 24.51 B C ATOM 9300 CG PHE B 53 79.155 51.313 −10.324 1.00 27.60 B C ATOM 9301 CD1 PHE B 53 78.559 50.556 −9.315 1.00 29.48 B C ATOM 9303 CE1 PHE B 53 78.400 51.071 −8.028 1.00 30.36 B C ATOM 9305 CZ PHE B 53 78.838 52.361 −7.739 1.00 31.69 B C ATOM 9307 CE2 PHE B 53 79.433 53.131 −8.739 1.00 31.11 B C ATOM 9309 CD2 PHE B 53 79.586 52.606 −10.024 1.00 30.30 B C ATOM 9311 C PHE B 53 79.933 48.739 −13.095 1.00 23.44 B C ATOM 9312 O PHE B 53 79.059 47.874 −13.177 1.00 23.35 B O ATOM 9314 N LEU B 54 80.715 49.073 −14.120 1.00 22.51 B N ATOM 9315 CA LEU B 54 80.622 48.377 −15.403 1.00 21.75 B C ATOM 9317 CB LEU B 54 81.416 49.117 −16.487 1.00 21.53 B C ATOM 9320 CG LEU B 54 81.023 48.812 −17.936 1.00 21.05 B C ATOM 9322 CD1 LEU B 54 79.602 49.279 −18.218 1.00 20.70 B C ATOM 9326 CD2 LEU B 54 81.997 49.461 −18.908 1.00 19.68 B C ATOM 9330 C LEU B 54 81.110 46.928 −15.267 1.00 21.34 B C ATOM 9331 O LEU B 54 80.503 46.011 −15.821 1.00 21.37 B O ATOM 9333 N THR B 55 82.195 46.731 −14.517 1.00 20.71 B N ATOM 9334 CA THR B 55 82.723 45.391 −14.241 1.00 20.02 B C ATOM 9336 CB THR B 55 84.090 45.459 −13.528 1.00 19.67 B C ATOM 9338 OG1 THR B 55 84.974 46.311 −14.264 1.00 18.17 B O ATOM 9340 CG2 THR B 55 84.706 44.071 −13.409 1.00 19.26 B C ATOM 9344 C THR B 55 81.763 44.569 −13.379 1.00 19.89 B C ATOM 9345 O THR B 55 81.651 43.353 −13.550 1.00 19.81 B O ATOM 9347 N LEU B 56 81.077 45.242 −12.456 1.00 19.76 B N ATOM 9348 CA LEU B 56 80.128 44.592 −11.552 1.00 19.79 B C ATOM 9350 CB LEU B 56 79.630 45.591 −10.500 1.00 19.92 B C ATOM 9353 CG LEU B 56 78.637 45.086 −9.449 1.00 20.73 B C ATOM 9355 CD1 LEU B 56 79.195 43.878 −8.703 1.00 21.48 B C ATOM 9359 CD2 LEU B 56 78.277 46.207 −8.476 1.00 21.77 B C ATOM 9363 C LEU B 56 78.941 44.014 −12.316 1.00 19.43 B C ATOM 9364 O LEU B 56 78.580 42.850 −12.136 1.00 19.59 B O ATOM 9366 N LEU B 57 78.341 44.840 −13.167 1.00 18.85 B N ATOM 9367 CA LEU B 57 77.219 44.412 −13.997 1.00 18.27 B C ATOM 9369 CB LEU B 57 76.672 45.590 −14.808 1.00 18.24 B C ATOM 9372 CG LEU B 57 76.112 46.770 −14.008 1.00 18.19 B C ATOM 9374 CD1 LEU B 57 75.894 47.973 −14.912 1.00 17.75 B C ATOM 9378 CD2 LEU B 57 74.824 46.382 −13.297 1.00 18.37 B C ATOM 9382 C LEU B 57 77.649 43.289 −14.938 1.00 17.71 B C ATOM 9383 O LEU B 57 76.922 42.311 −15.114 1.00 17.47 B O ATOM 9385 N GLU B 58 78.836 43.435 −15.527 1.00 17.20 B N ATOM 9386 CA GLU B 58 79.386 42.429 −16.440 1.00 16.77 B C ATOM 9388 CB GLU B 58 80.668 42.942 −17.110 1.00 16.93 B C ATOM 9391 CG GLU B 58 80.413 43.906 −18.269 1.00 18.82 B C ATOM 9394 CD GLU B 58 81.688 44.351 −18.983 1.00 20.53 B C ATOM 9395 OE1 GLU B 58 82.721 43.653 −18.876 1.00 22.18 B O ATOM 9396 OE2 GLU B 58 81.652 45.400 −19.662 1.00 20.87 B O ATOM 9397 C GLU B 58 79.655 41.080 −15.764 1.00 16.01 B C ATOM 9398 O GLU B 58 79.540 40.038 −16.409 1.00 16.08 B O ATOM 9400 N LEU B 59 80.011 41.095 −14.479 1.00 14.97 B N ATOM 9401 CA LEU B 59 80.244 39.849 −13.740 1.00 13.89 B C ATOM 9403 CB LEU B 59 80.915 40.117 −12.387 1.00 13.50 B C ATOM 9406 CG LEU B 59 81.070 38.917 −11.439 1.00 11.95 B C ATOM 9408 CD1 LEU B 59 81.657 37.699 −12.142 1.00 8.96 B C ATOM 9412 CD2 LEU B 59 81.921 39.295 −10.243 1.00 10.77 B C ATOM 9416 C LEU B 59 78.936 39.085 −13.541 1.00 13.42 B C ATOM 9417 O LEU B 59 78.852 37.904 −13.877 1.00 13.89 B O ATOM 9419 N ILE B 60 77.924 39.761 −12.999 1.00 12.45 B N ATOM 9420 CA ILE B 60 76.607 39.148 −12.804 1.00 11.69 B C ATOM 9422 CB ILE B 60 75.533 40.169 −12.356 1.00 11.55 B C ATOM 9424 CG1 ILE B 60 75.861 40.758 −10.982 1.00 11.14 B C ATOM 9427 CD1 ILE B 60 74.840 41.771 −10.494 1.00 9.21 B C ATOM 9431 CG2 ILE B 60 74.161 39.507 −12.311 1.00 10.73 B C ATOM 9435 C ILE B 60 76.139 38.535 −14.114 1.00 11.60 B C ATOM 9436 O ILE B 60 75.774 37.362 −14.167 1.00 11.32 B O ATOM 9438 N ASP B 61 76.168 39.348 −15.168 1.00 11.70 B N ATOM 9439 CA ASP B 61 75.739 38.927 −16.496 1.00 11.67 B C ATOM 9441 CB ASP B 61 75.996 40.041 −17.517 1.00 11.58 B C ATOM 9444 CG ASP B 61 75.344 39.772 −18.866 1.00 11.78 B C ATOM 9445 OD1 ASP B 61 74.350 39.015 −18.922 1.00 9.94 B O ATOM 9446 OD2 ASP B 61 75.826 40.332 −19.874 1.00 11.86 B O ATOM 9447 C ASP B 61 76.452 37.647 −16.914 1.00 11.90 B C ATOM 9448 O ASP B 61 75.823 36.740 −17.444 1.00 11.79 B O ATOM 9450 N ASN B 62 77.756 37.572 −16.660 1.00 12.59 B N ATOM 9451 CA ASN B 62 78.515 36.345 −16.917 1.00 13.39 B C ATOM 9453 CB ASN B 62 80.020 36.574 −16.725 1.00 13.48 B C ATOM 9456 CG ASN B 62 80.590 37.589 −17.699 1.00 13.93 B C ATOM 9457 OD1 ASN B 62 80.077 37.768 −18.803 1.00 13.75 B O ATOM 9458 ND2 ASN B 62 81.660 38.263 −17.290 1.00 16.15 B N ATOM 9461 C ASN B 62 78.049 35.192 −16.024 1.00 13.60 B C ATOM 9462 O ASN B 62 77.842 34.076 −16.500 1.00 13.11 B O ATOM 9464 N VAL B 63 77.873 35.473 −14.735 1.00 13.89 B N ATOM 9465 CA VAL B 63 77.447 34.458 −13.773 1.00 14.49 B C ATOM 9467 CB VAL B 63 77.327 35.041 −12.349 1.00 14.33 B C ATOM 9469 CG1 VAL B 63 76.681 34.034 −11.410 1.00 14.92 B C ATOM 9473 CG2 VAL B 63 78.693 35.452 −11.829 1.00 14.73 B C ATOM 9477 C VAL B 63 76.113 33.822 −14.170 1.00 15.20 B C ATOM 9478 O VAL B 63 75.986 32.596 −14.188 1.00 15.27 B O ATOM 9480 N GLN B 64 75.129 34.658 −14.490 1.00 15.80 B N ATOM 9481 CA GLN B 64 73.799 34.178 −14.875 1.00 16.00 B C ATOM 9483 CB GLN B 64 72.811 35.340 −14.962 1.00 16.04 B C ATOM 9486 CG GLN B 64 72.518 36.000 −13.630 1.00 16.27 B C ATOM 9489 CD GLN B 64 71.616 37.209 −13.762 1.00 16.56 B C ATOM 9490 OE1 GLN B 64 70.631 37.339 −13.035 1.00 19.83 B O ATOM 9491 NE2 GLN B 64 71.946 38.102 −14.693 1.00 12.79 B N ATOM 9494 C GLN B 64 73.825 33.441 −16.207 1.00 16.02 B C ATOM 9495 O GLN B 64 73.141 32.434 −16.375 1.00 16.54 B O ATOM 9497 N ARG B 65 74.612 33.950 −17.150 1.00 16.05 B N ATOM 9498 CA ARG B 65 74.721 33.338 −18.473 1.00 16.17 B C ATOM 9500 CB ARG B 65 75.346 34.315 −19.473 1.00 16.27 B C ATOM 9503 CG ARG B 65 74.403 35.458 −19.834 1.00 18.62 B C ATOM 9506 CD ARG B 65 74.945 36.347 −20.935 1.00 19.52 B C ATOM 9509 NE ARG B 65 74.972 35.651 −22.219 1.00 21.90 B N ATOM 9511 CZ ARG B 65 75.080 36.245 −23.405 1.00 25.25 B C ATOM 9512 NH1 ARG B 65 75.161 37.571 −23.503 1.00 26.87 B N ATOM 9515 NH2 ARG B 65 75.099 35.504 −24.509 1.00 26.60 B N ATOM 9518 C ARG B 65 75.494 32.020 −18.451 1.00 15.57 B C ATOM 9519 O ARG B 65 75.292 31.179 −19.322 1.00 16.17 B O ATOM 9521 N LEU B 66 76.361 31.838 −17.454 1.00 14.50 B N ATOM 9522 CA LEU B 66 77.091 30.575 −17.275 1.00 13.62 B C ATOM 9524 CB LEU B 66 78.445 30.836 −16.606 1.00 13.45 B C ATOM 9527 CG LEU B 66 79.441 31.662 −17.429 1.00 12.05 B C ATOM 9529 CD1 LEU B 66 80.499 32.279 −16.532 1.00 11.23 B C ATOM 9533 CD2 LEU B 66 80.081 30.824 −18.518 1.00 9.81 B C ATOM 9537 C LEU B 66 76.283 29.546 −16.468 1.00 13.36 B C ATOM 9538 O LEU B 66 76.797 28.480 −16.116 1.00 12.46 B O ATOM 9540 N GLY B 67 75.024 29.880 −16.175 1.00 13.57 B N ATOM 9541 CA GLY B 67 74.089 28.970 −15.518 1.00 13.40 B C ATOM 9544 C GLY B 67 74.004 29.124 −14.009 1.00 13.53 B C ATOM 9545 O GLY B 67 73.192 28.456 −13.367 1.00 13.68 B O ATOM 9547 N LEU B 68 74.812 30.020 −13.442 1.00 13.50 B N ATOM 9548 CA LEU B 68 75.000 30.092 −11.988 1.00 13.46 B C ATOM 9550 CB LEU B 68 76.484 30.330 −11.678 1.00 13.16 B C ATOM 9553 CG LEU B 68 77.467 29.318 −12.274 1.00 12.36 B C ATOM 9555 CD1 LEU B 68 78.899 29.699 −11.919 1.00 11.43 B C ATOM 9559 CD2 LEU B 68 77.152 27.905 −11.803 1.00 9.64 B C ATOM 9563 C LEU B 68 74.149 31.150 −11.266 1.00 13.59 B C ATOM 9564 O LEU B 68 74.430 31.485 −10.117 1.00 13.36 B O ATOM 9566 N GLY B 69 73.105 31.658 −11.916 1.00 13.93 B N ATOM 9567 CA GLY B 69 72.275 32.714 −11.327 1.00 14.33 B C ATOM 9570 C GLY B 69 71.461 32.277 −10.117 1.00 14.49 B C ATOM 9571 O GLY B 69 71.331 33.023 −9.142 1.00 14.33 B O ATOM 9573 N TYR B 70 70.910 31.067 −10.184 1.00 14.76 B N ATOM 9574 CA TYR B 70 70.127 30.493 −9.080 1.00 14.94 B C ATOM 9576 CB TYR B 70 69.535 29.136 −9.493 1.00 14.57 B C ATOM 9579 CG TYR B 70 70.532 27.992 −9.554 1.00 12.18 B C ATOM 9580 CD1 TYR B 70 70.607 27.053 −8.530 1.00 9.68 B C ATOM 9582 CE1 TYR B 70 71.511 25.999 −8.585 1.00 8.46 B C ATOM 9584 CZ TYR B 70 72.353 25.874 −9.673 1.00 8.09 B C ATOM 9585 OH TYR B 70 73.251 24.837 −9.733 1.00 2.16 B O ATOM 9587 CE2 TYR B 70 72.300 26.789 −10.701 1.00 10.87 B C ATOM 9589 CD2 TYR B 70 71.390 27.841 −10.640 1.00 12.42 B C ATOM 9591 C TYR B 70 70.929 30.328 −7.783 1.00 15.65 B C ATOM 9592 O TYR B 70 70.354 30.256 −6.696 1.00 15.92 B O ATOM 9594 N ARG B 71 72.251 30.270 −7.911 1.00 16.20 B N ATOM 9595 CA ARG B 71 73.144 30.017 −6.785 1.00 16.52 B C ATOM 9597 CB ARG B 71 74.387 29.275 −7.292 1.00 16.53 B C ATOM 9600 CG ARG B 71 75.487 29.079 −6.269 1.00 18.42 B C ATOM 9603 CD ARG B 71 76.353 27.866 −6.587 1.00 20.45 B C ATOM 9606 NE ARG B 71 75.889 26.669 −5.880 1.00 20.38 B N ATOM 9608 CZ ARG B 71 75.159 25.689 −6.412 1.00 18.95 B C ATOM 9609 NH1 ARG B 71 74.803 24.658 −5.656 1.00 19.37 B N ATOM 9612 NH2 ARG B 71 74.783 25.719 −7.686 1.00 18.08 B N ATOM 9615 C ARG B 71 73.536 31.290 −6.029 1.00 16.71 B C ATOM 9616 O ARG B 71 73.904 31.216 −4.856 1.00 17.32 B O ATOM 9618 N PHE B 72 73.446 32.448 −6.686 1.00 16.77 B N ATOM 9619 CA PHE B 72 73.869 33.722 −6.084 1.00 16.64 B C ATOM 9621 CB PHE B 72 75.080 34.285 −6.839 1.00 16.18 B C ATOM 9624 CG PHE B 72 76.285 33.396 −6.807 1.00 14.45 B C ATOM 9625 CD1 PHE B 72 77.151 33.422 −5.726 1.00 14.72 B C ATOM 9627 CE1 PHE B 72 78.270 32.602 −5.696 1.00 15.49 B C ATOM 9629 CZ PHE B 72 78.529 31.748 −6.758 1.00 14.51 B C ATOM 9631 CE2 PHE B 72 77.672 31.718 −7.840 1.00 12.96 B C ATOM 9633 CD2 PHE B 72 76.559 32.540 −7.861 1.00 12.86 B C ATOM 9635 C PHE B 72 72.771 34.789 −6.055 1.00 17.23 B C ATOM 9636 O PHE B 72 73.070 35.966 −5.846 1.00 17.54 B O ATOM 9638 N GLU B 73 71.511 34.392 −6.241 1.00 17.68 B N ATOM 9639 CA GLU B 73 70.417 35.362 −6.381 1.00 17.82 B C ATOM 9641 CB GLU B 73 69.044 34.677 −6.330 1.00 17.51 B C ATOM 9644 CG GLU B 73 67.872 35.639 −6.556 1.00 17.32 B C ATOM 9647 CD GLU B 73 66.574 34.938 −6.923 1.00 18.12 B C ATOM 9648 OE1 GLU B 73 66.536 34.246 −7.964 1.00 17.38 B O ATOM 9649 OE2 GLU B 73 65.582 35.097 −6.181 1.00 18.22 B O ATOM 9650 C GLU B 73 70.492 36.495 −5.347 1.00 18.27 B C ATOM 9651 O GLU B 73 70.561 37.666 −5.720 1.00 18.56 B O ATOM 9653 N SER B 74 70.503 36.156 −4.061 1.00 18.44 B N ATOM 9654 CA SER B 74 70.518 37.184 −3.016 1.00 19.13 B C ATOM 9656 CB SER B 74 70.471 36.564 −1.617 1.00 19.31 B C ATOM 9659 OG SER B 74 71.749 36.099 −1.218 1.00 20.88 B O ATOM 9661 C SER B 74 71.751 38.075 −3.137 1.00 19.37 B C ATOM 9662 O SER B 74 71.649 39.304 −3.058 1.00 19.55 B O ATOM 9664 N ASP B 75 72.910 37.448 −3.330 1.00 19.39 B N ATOM 9665 CA ASP B 75 74.168 38.181 −3.468 1.00 19.25 B C ATOM 9667 CB ASP B 75 75.355 37.219 −3.618 1.00 18.87 B C ATOM 9670 CG ASP B 75 75.559 36.340 −2.387 1.00 18.85 B C ATOM 9671 OD1 ASP B 75 76.370 36.708 −1.510 1.00 15.51 B O ATOM 9672 OD2 ASP B 75 74.897 35.284 −2.293 1.00 19.53 B O ATOM 9673 C ASP B 75 74.090 39.139 −4.656 1.00 19.33 B C ATOM 9674 O ASP B 75 74.564 40.274 −4.579 1.00 19.40 B O ATOM 9676 N ILE B 76 73.466 38.682 −5.739 1.00 19.53 B N ATOM 9677 CA ILE B 76 73.258 39.509 −6.927 1.00 19.92 B C ATOM 9679 CB ILE B 76 72.762 38.664 −8.128 1.00 19.83 B C ATOM 9681 CG1 ILE B 76 73.868 37.717 −8.599 1.00 19.94 B C ATOM 9684 CD1 ILE B 76 73.384 36.631 −9.528 1.00 21.34 B C ATOM 9688 CG2 ILE B 76 72.335 39.560 −9.283 1.00 19.40 B C ATOM 9692 C ILE B 76 72.277 40.652 −6.647 1.00 20.43 B C ATOM 9693 O ILE B 76 72.535 41.796 −7.028 1.00 20.62 B O ATOM 9695 N ARG B 77 71.165 40.342 −5.977 1.00 20.78 B N ATOM 9696 CA ARG B 77 70.175 41.360 −5.595 1.00 21.05 B C ATOM 9698 CB ARG B 77 68.985 40.722 −4.877 1.00 21.27 B C ATOM 9701 CG ARG B 77 68.098 39.864 −5.760 1.00 23.04 B C ATOM 9704 CD ARG B 77 67.085 39.093 −4.924 1.00 25.79 B C ATOM 9707 NE ARG B 77 66.125 39.989 −4.281 1.00 27.15 B N ATOM 9709 CZ ARG B 77 65.054 40.514 −4.878 1.00 28.90 B C ATOM 9710 NH1 ARG B 77 64.777 40.244 −6.152 1.00 29.24 B N ATOM 9713 NH2 ARG B 77 64.251 41.320 −4.193 1.00 30.29 B N ATOM 9716 C ARG B 77 70.785 42.436 −4.697 1.00 20.82 B C ATOM 9717 O ARG B 77 70.469 43.618 −4.833 1.00 20.93 B O ATOM 9719 N GLY B 78 71.653 42.016 −3.780 1.00 20.58 B N ATOM 9720 CA GLY B 78 72.387 42.943 −2.924 1.00 20.53 B C ATOM 9723 C GLY B 78 73.409 43.788 −3.670 1.00 20.38 B C ATOM 9724 O GLY B 78 73.801 44.851 −3.193 1.00 20.60 B O ATOM 9726 N ALA B 79 73.847 43.313 −4.835 1.00 20.03 B N ATOM 9727 CA ALA B 79 74.777 44.060 −5.680 1.00 20.01 B C ATOM 9729 CB ALA B 79 75.425 43.132 −6.694 1.00 20.01 B C ATOM 9733 C ALA B 79 74.077 45.210 −6.396 1.00 20.07 B C ATOM 9734 O ALA B 79 74.580 46.333 −6.424 1.00 19.81 B O ATOM 9736 N LEU B 80 72.918 44.921 −6.981 1.00 20.65 B N ATOM 9737 CA LEU B 80 72.145 45.928 −7.706 1.00 21.23 B C ATOM 9739 CB LEU B 80 71.039 45.265 −8.533 1.00 21.22 B C ATOM 9742 CG LEU B 80 71.509 44.313 −9.637 1.00 22.04 B C ATOM 9744 CD1 LEU B 80 70.315 43.623 −10.295 1.00 22.93 B C ATOM 9748 CD2 LEU B 80 72.349 45.047 −10.677 1.00 21.09 B C ATOM 9752 C LEU B 80 71.538 46.967 −6.764 1.00 21.81 B C ATOM 9753 O LEU B 80 71.402 48.135 −7.129 1.00 22.20 B O ATOM 9755 N ASP B 81 71.178 46.544 −5.555 1.00 22.17 B N ATOM 9756 CA ASP B 81 70.651 47.463 −4.543 1.00 22.35 B C ATOM 9758 CB ASP B 81 70.188 46.692 −3.303 1.00 22.43 B C ATOM 9761 CG ASP B 81 69.122 47.433 −2.521 1.00 23.43 B C ATOM 9762 OD1 ASP B 81 69.403 47.854 −1.377 1.00 24.99 B O ATOM 9763 OD2 ASP B 81 68.004 47.598 −3.055 1.00 23.01 B O ATOM 9764 C ASP B 81 71.705 48.509 −4.158 1.00 22.33 B C ATOM 9765 O ASP B 81 71.374 49.658 −3.862 1.00 22.00 B O ATOM 9767 N ARG B 82 72.970 48.091 −4.160 1.00 22.64 B N ATOM 9768 CA ARG B 82 74.110 48.997 −3.992 1.00 23.00 B C ATOM 9770 CB ARG B 82 75.429 48.207 −3.977 1.00 23.31 B C ATOM 9773 CG ARG B 82 76.436 48.600 −2.894 1.00 23.85 B C ATOM 9776 CD ARG B 82 76.608 47.462 −1.902 1.00 25.49 B C ATOM 9779 NE ARG B 82 77.031 46.237 −2.588 1.00 27.67 B N ATOM 9781 CZ ARG B 82 76.736 44.993 −2.208 1.00 28.92 B C ATOM 9782 NH1 ARG B 82 75.999 44.755 −1.125 1.00 29.74 B N ATOM 9785 NH2 ARG B 82 77.175 43.967 −2.929 1.00 28.09 B N ATOM 9788 C ARG B 82 74.150 49.964 −5.168 1.00 22.98 B C ATOM 9789 O ARG B 82 74.309 51.174 −4.997 1.00 23.04 B O ATOM 9791 N PHE B 83 74.012 49.394 −6.363 1.00 22.90 B N ATOM 9792 CA PHE B 83 74.097 50.131 −7.620 1.00 22.96 B C ATOM 9794 CB PHE B 83 73.907 49.159 −8.788 1.00 22.83 B C ATOM 9797 CG PHE B 83 74.055 49.790 −10.137 1.00 22.79 B C ATOM 9798 CD1 PHE B 83 75.264 50.338 −10.527 1.00 22.61 B C ATOM 9800 CE1 PHE B 83 75.411 50.916 −11.776 1.00 23.30 B C ATOM 9802 CZ PHE B 83 74.340 50.941 −12.656 1.00 23.91 B C ATOM 9804 CE2 PHE B 83 73.126 50.391 −12.281 1.00 23.32 B C ATOM 9806 CD2 PHE B 83 72.989 49.816 −11.029 1.00 23.33 B C ATOM 9808 C PHE B 83 73.081 51.269 −7.701 1.00 23.09 B C ATOM 9809 O PHE B 83 73.424 52.381 −8.102 1.00 23.19 B O ATOM 9811 N VAL B 84 71.840 50.989 −7.312 1.00 23.08 B N ATOM 9812 CA VAL B 84 70.778 51.996 −7.336 1.00 23.11 B C ATOM 9814 CB VAL B 84 69.379 51.347 −7.184 1.00 23.15 B C ATOM 9816 CG1 VAL B 84 68.319 52.402 −6.884 1.00 22.64 B C ATOM 9820 CG2 VAL B 84 69.019 50.564 −8.441 1.00 22.66 B C ATOM 9824 C VAL B 84 70.969 53.048 −6.244 1.00 23.28 B C ATOM 9825 O VAL B 84 70.892 54.248 −6.513 1.00 23.33 B O ATOM 9827 N SER B 85 71.223 52.590 −5.020 1.00 23.59 B N ATOM 9828 CA SER B 85 71.289 53.472 −3.848 1.00 23.83 B C ATOM 9830 CB SER B 85 71.287 52.643 −2.559 1.00 24.07 B C ATOM 9833 OG SER B 85 72.375 51.733 −2.529 1.00 25.24 B O ATOM 9835 C SER B 85 72.493 54.417 −3.851 1.00 23.55 B C ATOM 9836 O SER B 85 72.401 55.534 −3.342 1.00 23.23 B O ATOM 9838 N SER B 86 73.612 53.973 −4.425 1.00 23.60 B N ATOM 9839 CA SER B 86 74.814 54.810 −4.524 1.00 23.71 B C ATOM 9841 CB SER B 86 76.076 53.937 −4.571 1.00 23.57 B C ATOM 9844 OG SER B 86 76.163 53.204 −5.781 1.00 23.18 B O ATOM 9846 C SER B 86 74.784 55.748 −5.738 1.00 23.94 B C ATOM 9847 O SER B 86 75.764 56.444 −6.007 1.00 23.67 B O ATOM 9849 N GLY B 87 73.664 55.764 −6.462 1.00 24.30 B N ATOM 9850 CA GLY B 87 73.511 56.602 −7.648 1.00 24.62 B C ATOM 9853 C GLY B 87 74.240 56.061 −8.866 1.00 24.97 B C ATOM 9854 O GLY B 87 74.698 56.832 −9.711 1.00 25.27 B O ATOM 9856 N GLY B 88 74.350 54.737 −8.960 1.00 25.14 B N ATOM 9857 CA GLY B 88 75.008 54.090 −10.096 1.00 25.27 B C ATOM 9860 C GLY B 88 74.123 54.077 −11.330 1.00 25.47 B C ATOM 9861 O GLY B 88 74.598 54.303 −12.446 1.00 25.09 B O ATOM 9863 N PHE B 89 72.834 53.811 −11.123 1.00 25.86 B N ATOM 9864 CA PHE B 89 71.847 53.814 −12.206 1.00 26.07 B C ATOM 9866 CB PHE B 89 70.486 53.334 −11.688 1.00 26.21 B C ATOM 9869 CG PHE B 89 69.389 53.363 −12.723 1.00 26.68 B C ATOM 9870 CD1 PHE B 89 69.523 52.660 −13.915 1.00 26.40 B C ATOM 9872 CE1 PHE B 89 68.513 52.681 −14.871 1.00 26.69 B C ATOM 9874 CZ PHE B 89 67.350 53.404 −14.636 1.00 27.08 B C ATOM 9876 CE2 PHE B 89 67.202 54.104 −13.448 1.00 27.35 B C ATOM 9878 CD2 PHE B 89 68.217 54.080 −12.498 1.00 27.23 B C ATOM 9880 C PHE B 89 71.714 55.204 −12.818 1.00 26.15 B C ATOM 9881 O PHE B 89 71.593 55.344 −14.035 1.00 26.29 B O ATOM 9883 N ASP B 90 71.741 56.224 −11.964 1.00 26.08 B N ATOM 9884 CA ASP B 90 71.678 57.612 −12.411 1.00 26.14 B C ATOM 9886 CB ASP B 90 71.389 58.536 −11.222 1.00 26.54 B C ATOM 9889 CG ASP B 90 70.904 59.914 −11.651 1.00 28.73 B C ATOM 9890 OD1 ASP B 90 71.751 60.801 −11.913 1.00 29.84 B O ATOM 9891 OD2 ASP B 90 69.671 60.112 −11.709 1.00 31.49 B O ATOM 9892 C ASP B 90 72.971 58.042 −13.113 1.00 25.74 B C ATOM 9893 O ASP B 90 72.949 58.939 −13.955 1.00 26.14 B O ATOM 9895 N ALA B 91 74.089 57.400 −12.770 1.00 25.04 B N ATOM 9896 CA ALA B 91 75.395 57.742 −13.343 1.00 24.47 B C ATOM 9898 CB ALA B 91 76.517 57.190 −12.470 1.00 24.49 B C ATOM 9902 C ALA B 91 75.555 57.246 −14.780 1.00 23.98 B C ATOM 9903 O ALA B 91 75.966 58.005 −15.657 1.00 23.86 B O ATOM 9905 N VAL B 92 75.231 55.976 −15.016 1.00 23.68 B N ATOM 9906 CA VAL B 92 75.405 55.365 −16.341 1.00 23.29 B C ATOM 9908 CB VAL B 92 75.211 53.832 −16.307 1.00 23.10 B C ATOM 9910 CG1 VAL B 92 76.248 53.187 −15.399 1.00 22.67 B C ATOM 9914 CG2 VAL B 92 73.795 53.473 −15.868 1.00 23.29 B C ATOM 9918 C VAL B 92 74.474 55.949 −17.406 1.00 23.09 B C ATOM 9919 O VAL B 92 74.862 56.059 −18.569 1.00 23.06 B O ATOM 9921 N THR B 93 73.260 56.333 −17.009 1.00 22.98 B N ATOM 9922 CA THR B 93 72.277 56.894 −17.948 1.00 22.80 B C ATOM 9924 CB THR B 93 70.887 57.094 −17.293 1.00 22.75 B C ATOM 9926 OG1 THR B 93 71.002 57.966 −16.161 1.00 21.89 B O ATOM 9928 CG2 THR B 93 70.299 55.756 −16.859 1.00 22.59 B C ATOM 9932 C THR B 93 72.721 58.224 −18.567 1.00 22.54 B C ATOM 9933 O THR B 93 72.142 58.664 −19.562 1.00 22.69 B O ATOM 9935 N LYS B 94 73.734 58.857 −17.974 1.00 22.08 B N ATOM 9936 CA LYS B 94 74.346 60.061 −18.539 1.00 21.85 B C ATOM 9938 CB LYS B 94 74.849 60.989 −17.422 1.00 21.89 B C ATOM 9941 CG LYS B 94 73.825 61.316 −16.333 1.00 22.60 B C ATOM 9944 CD LYS B 94 72.573 61.989 −16.885 1.00 23.74 B C ATOM 9947 CE LYS B 94 71.570 62.282 −15.779 1.00 24.01 B C ATOM 9950 NZ LYS B 94 70.262 62.747 −16.319 1.00 23.58 B N ATOM 9954 C LYS B 94 75.509 59.724 −19.479 1.00 21.38 B C ATOM 9955 O LYS B 94 75.748 60.447 −20.450 1.00 21.29 B O ATOM 9957 N THR B 95 76.219 58.629 −19.193 1.00 20.80 B N ATOM 9958 CA THR B 95 77.463 58.288 −19.898 1.00 20.16 B C ATOM 9960 CB THR B 95 78.598 57.987 −18.892 1.00 20.05 B C ATOM 9962 OG1 THR B 95 78.226 56.884 −18.054 1.00 19.86 B O ATOM 9964 CG2 THR B 95 78.882 59.208 −18.027 1.00 19.17 B C ATOM 9968 C THR B 95 77.337 57.110 −20.880 1.00 19.76 B C ATOM 9969 O THR B 95 77.331 57.315 −22.097 1.00 19.67 B O ATOM 9971 N SER B 96 77.238 55.889 −20.352 1.00 19.17 B N ATOM 9972 CA SER B 96 77.321 54.673 −21.172 1.00 18.55 B C ATOM 9974 CB SER B 96 78.197 53.631 −20.474 1.00 18.28 B C ATOM 9977 OG SER B 96 78.356 52.478 −21.284 1.00 16.95 B O ATOM 9979 C SER B 96 75.957 54.055 −21.474 1.00 18.37 B C ATOM 9980 O SER B 96 75.124 53.907 −20.581 1.00 18.51 B O ATOM 9982 N LEU B 97 75.749 53.681 −22.737 1.00 18.03 B N ATOM 9983 CA LEU B 97 74.538 52.970 −23.156 1.00 17.63 B C ATOM 9985 CB LEU B 97 74.358 53.060 −24.676 1.00 17.43 B C ATOM 9988 CG LEU B 97 73.200 52.279 −25.308 1.00 16.33 B C ATOM 9990 CD1 LEU B 97 71.862 52.622 −24.663 1.00 14.88 B C ATOM 9994 CD2 LEU B 97 73.158 52.544 −26.799 1.00 15.23 B C ATOM 9998 C LEU B 97 74.616 51.509 −22.721 1.00 17.57 B C ATOM 9999 O LEU B 97 73.726 51.012 −22.031 1.00 17.48 B O ATOM 10001 N HIS B 98 75.685 50.833 −23.135 1.00 17.59 B N ATOM 10002 CA HIS B 98 75.953 49.450 −22.732 1.00 17.51 B C ATOM 10004 CB HIS B 98 77.430 49.107 −22.981 1.00 17.79 B C ATOM 10007 CG HIS B 98 77.888 47.849 −22.309 1.00 18.71 B C ATOM 10008 ND1 HIS B 98 77.360 46.610 −22.602 1.00 20.03 B N ATOM 10010 CE1 HIS B 98 77.959 45.693 −21.863 1.00 20.85 B C ATOM 10012 NE2 HIS B 98 78.861 46.291 −21.106 1.00 20.28 B N ATOM 10014 CD2 HIS B 98 78.839 47.639 −21.367 1.00 19.98 B C ATOM 10016 C HIS B 98 75.606 49.243 −21.265 1.00 17.07 B C ATOM 10017 O HIS B 98 74.733 48.441 −20.934 1.00 17.09 B O ATOM 10019 N GLY B 99 76.280 49.994 −20.399 1.00 16.69 B N ATOM 10020 CA GLY B 99 76.080 49.903 −18.956 1.00 16.27 B C ATOM 10023 C GLY B 99 74.644 50.107 −18.510 1.00 15.82 B C ATOM 10024 O GLY B 99 74.218 49.516 −17.518 1.00 15.84 B O ATOM 10026 N THR B 100 73.902 50.946 −19.233 1.00 15.36 B N ATOM 10027 CA THR B 100 72.492 51.200 −18.928 1.00 15.12 B ATOM 10029 CB THR B 100 71.989 52.511 −19.582 1.00 15.04 B C ATOM 10031 OG1 THR B 100 72.701 53.626 −19.034 1.00 14.95 B O ATOM 10033 CG2 THR B 100 70.500 52.706 −19.336 1.00 14.68 B C ATOM 10037 C THR B 100 71.612 50.036 −19.380 1.00 14.98 B C ATOM 10038 O THR B 100 70.745 49.587 −18.636 1.00 14.55 B O ATOM 10040 N ALA B 101 71.846 49.552 −20.596 1.00 15.35 B N ATOM 10041 CA ALA B 101 71.059 48.452 −21.162 1.00 15.58 B C ATOM 10043 CB ALA B 101 71.386 48.281 −22.637 1.00 15.49 B C ATOM 10047 C ALA B 101 71.281 47.135 −20.413 1.00 15.71 B C ATOM 10048 O ALA B 101 70.392 46.278 −20.369 1.00 16.00 B O ATOM 10050 N LEU B 102 72.470 46.978 −19.838 1.00 15.43 B N ATOM 10051 CA LEU B 102 72.788 45.817 −19.011 1.00 15.11 B C ATOM 10053 CB LEU B 102 74.306 45.698 −18.828 1.00 14.88 B C ATOM 10056 CG LEU B 102 74.848 44.512 −18.029 1.00 13.96 B C ATOM 10058 CD1 LEU B 102 74.261 43.198 −18.515 1.00 13.62 B C ATOM 10062 CD2 LEU B 102 76.369 44.488 −18.109 1.00 13.07 B C ATOM 10066 C LEU B 102 72.096 45.934 −17.654 1.00 15.05 B C ATOM 10067 O LEU B 102 71.425 45.000 −17.210 1.00 15.13 B O ATOM 10069 N SER B 103 72.254 47.089 −17.010 1.00 14.64 B N ATOM 10070 CA SER B 103 71.667 47.325 −15.695 1.00 14.21 B C ATOM 10072 CB SER B 103 72.208 48.613 −15.068 1.00 14.05 B C ATOM 10075 OG SER B 103 71.690 49.766 −15.705 1.00 13.39 B O ATOM 10077 C SER B 103 70.148 47.383 −15.764 1.00 14.45 B C ATOM 10078 O SER B 103 69.471 46.896 −14.862 1.00 15.34 B O ATOM 10080 N PHE B 104 69.611 47.976 −16.827 1.00 14.20 B N ATOM 10081 CA PHE B 104 68.163 48.010 −17.017 1.00 13.83 B C ATOM 10083 CB PHE B 104 67.792 48.649 −18.356 1.00 14.07 B C ATOM 10086 CG PHE B 104 66.311 48.706 −18.608 1.00 14.64 B C ATOM 10087 CD1 PHE B 104 65.589 49.850 −18.309 1.00 15.83 B C ATOM 10089 CE1 PHE B 104 64.220 49.905 −18.538 1.00 16.59 B C ATOM 10091 CZ PHE B 104 63.562 48.807 −19.068 1.00 16.05 B C ATOM 10093 CE2 PHE B 104 64.272 47.660 −19.368 1.00 15.67 B C ATOM 10095 CD2 PHE B 104 65.639 47.612 −19.140 1.00 15.20 B C ATOM 10097 C PHE B 104 67.627 46.594 −16.966 1.00 13.24 B C ATOM 10098 O PHE B 104 66.718 46.295 −16.194 1.00 13.15 B O ATOM 10100 N ARG B 105 68.211 45.731 −17.794 1.00 13.05 B N ATOM 10101 CA ARG B 105 67.795 44.334 −17.904 1.00 13.08 B C ATOM 10103 CB ARG B 105 68.620 43.617 −18.977 1.00 13.37 B C ATOM 10106 CG ARG B 105 68.162 42.196 −19.273 1.00 13.35 B C ATOM 10109 CD ARG B 105 68.759 41.681 −20.576 1.00 12.99 B C ATOM 10112 NE ARG B 105 70.219 41.615 −20.518 1.00 12.68 B N ATOM 10114 CZ ARG B 105 70.918 40.672 −19.885 1.00 10.95 B C ATOM 10115 NH1 ARG B 105 70.309 39.686 −19.231 1.00 9.34 B N ATOM 10118 NH2 ARG B 105 72.246 40.718 −19.902 1.00 10.70 B N ATOM 10121 C ARG B 105 67.936 43.602 −16.578 1.00 12.52 B C ATOM 10122 O ARG B 105 66.992 42.967 −16.106 1.00 12.65 B O ATOM 10124 N LEU B 106 69.119 43.697 −15.983 1.00 11.82 B N ATOM 10125 CA LEU B 106 69.380 43.060 −14.699 1.00 11.23 B C ATOM 10127 CB LEU B 106 70.827 43.314 −14.255 1.00 10.81 B C ATOM 10130 CG LEU B 106 71.911 42.650 −15.109 1.00 8.27 B C ATOM 10132 CD1 LEU B 106 73.282 43.156 −14.714 1.00 6.17 B C ATOM 10136 CD2 LEU B 106 71.845 41.141 −14.993 1.00 6.13 B C ATOM 10140 C LEU B 106 68.395 43.548 −13.635 1.00 11.04 B C ATOM 10141 O LEU B 106 67.783 42.745 −12.939 1.00 10.80 B O ATOM 10143 N LEU B 107 68.229 44.862 −13.528 1.00 11.29 B N ATOM 10144 CA LEU B 107 67.332 45.436 −12.525 1.00 11.68 B C ATOM 10146 CB LEU B 107 67.324 46.967 −12.603 1.00 11.63 B C ATOM 10149 CG LEU B 107 68.511 47.671 −11.943 1.00 10.96 B C ATOM 10151 CD1 LEU B 107 68.589 49.129 −12.377 1.00 9.53 B C ATOM 10155 CD2 LEU B 107 68.414 47.555 −10.424 1.00 11.26 B C ATOM 10159 C LEU B 107 65.912 44.901 −12.671 1.00 11.95 B C ATOM 10160 O LEU B 107 65.323 44.423 −11.700 1.00 12.00 B O ATOM 10162 N ARG B 108 65.370 44.972 −13.882 1.00 12.17 B N ATOM 10163 CA ARG B 108 64.004 44.516 −14.122 1.00 12.61 B C ATOM 10165 CB ARG B 108 63.535 44.888 −15.526 1.00 12.46 B C ATOM 10168 CG ARG B 108 62.082 44.523 −15.779 1.00 11.97 B C ATOM 10171 CD ARG B 108 61.486 45.308 −16.924 1.00 11.34 B C ATOM 10174 NE ARG B 108 61.210 46.693 −16.555 1.00 10.21 B N ATOM 10176 CZ ARG B 108 60.650 47.590 −17.362 1.00 10.94 B C ATOM 10177 NH1 ARG B 108 60.296 47.265 −18.603 1.00 10.42 B N ATOM 10180 NH2 ARG B 108 60.443 48.825 −16.924 1.00 11.87 B N ATOM 10183 C ARG B 108 63.867 43.011 −13.905 1.00 13.23 B C ATOM 10184 O ARG B 108 62.876 42.554 −13.338 1.00 13.51 B O ATOM 10186 N GLN B 109 64.861 42.252 −14.359 1.00 13.93 B N ATOM 10187 CA GLN B 109 64.893 40.802 −14.148 1.00 14.40 B C ATOM 10189 CB GLN B 109 66.224 40.225 −14.650 1.00 14.43 B C ATOM 10192 CG GLN B 109 66.353 38.709 −14.555 1.00 13.91 B C ATOM 10195 CD GLN B 109 67.800 38.247 −14.560 1.00 12.71 B C ATOM 10196 OE1 GLN B 109 68.652 38.840 −15.222 1.00 12.98 B O ATOM 10197 NE2 GLN B 109 68.083 37.183 −13.819 1.00 12.06 B N ATOM 10200 C GLN B 109 64.695 40.461 −12.670 1.00 14.82 B C ATOM 10201 O GLN B 109 63.935 39.551 −12.336 1.00 15.14 B O ATOM 10203 N HIS B 110 65.369 41.208 −11.795 1.00 15.02 B N ATOM 10204 CA HIS B 110 65.307 40.977 −10.351 1.00 15.34 B C ATOM 10206 CB HIS B 110 66.702 41.147 −9.732 1.00 15.49 B C ATOM 10209 CG HIS B 110 67.692 40.110 −10.168 1.00 14.40 B C ATOM 10210 ND1 HIS B 110 67.790 38.876 −9.563 1.00 13.44 B N ATOM 10212 CE1 HIS B 110 68.749 38.178 −10.145 1.00 13.56 B C ATOM 10214 NE2 HIS B 110 69.280 38.917 −11.101 1.00 11.71 B N ATOM 10216 CD2 HIS B 110 68.639 40.130 −11.135 1.00 12.93 B C ATOM 10218 C HIS B 110 64.300 41.899 −9.644 1.00 15.77 B C ATOM 10219 O HIS B 110 64.591 42.451 −8.578 1.00 15.94 B O ATOM 10221 N GLY B 111 63.127 42.075 −10.248 1.00 16.02 B N ATOM 10222 CA GLY B 111 61.992 42.729 −9.590 1.00 16.43 B C ATOM 10225 C GLY B 111 62.109 44.199 −9.205 1.00 16.88 B C ATOM 10226 O GLY B 111 61.257 44.708 −8.474 1.00 16.73 B O ATOM 10228 N PHE B 112 63.143 44.890 −9.683 1.00 17.42 B N ATOM 10229 CA PHE B 112 63.274 46.328 −9.438 1.00 17.67 B C ATOM 10231 CB PHE B 112 64.722 46.798 −9.597 1.00 17.98 B C ATOM 10234 CG PHE B 112 65.615 46.412 −8.460 1.00 19.28 B C ATOM 10235 CD1 PHE B 112 65.605 47.143 −7.281 1.00 20.60 B C ATOM 10237 CE1 PHE B 112 66.431 46.796 −6.222 1.00 22.44 B C ATOM 10239 CZ PHE B 112 67.287 45.710 −6.339 1.00 22.18 B C ATOM 10241 CE2 PHE B 112 67.309 44.976 −7.515 1.00 21.88 B C ATOM 10243 CD2 PHE B 112 66.477 45.329 −8.569 1.00 20.40 B C ATOM 10245 C PHE B 112 62.397 47.100 −10.406 1.00 17.64 B C ATOM 10246 O PHE B 112 62.039 46.594 −11.470 1.00 17.30 B O ATOM 10248 N GLU B 113 62.053 48.329 −10.036 1.00 18.13 B N ATOM 10249 CA GLU B 113 61.356 49.217 −10.952 1.00 18.59 B C ATOM 10251 CB GLU B 113 60.339 50.108 −10.227 1.00 18.94 B C ATOM 10254 CG GLU B 113 59.591 51.062 −11.178 1.00 20.95 B C ATOM 10257 CD GLU B 113 58.188 51.435 −10.710 1.00 22.45 B C ATOM 10258 OE1 GLU B 113 57.949 51.484 −9.485 1.00 25.01 B O ATOM 10259 OE2 GLU B 113 57.324 51.691 −11.577 1.00 21.27 B O ATOM 10260 C GLU B 113 62.375 50.068 −11.697 1.00 18.18 B C ATOM 10261 O GLU B 113 63.150 50.806 −11.085 1.00 17.81 B O ATOM 10263 N VAL B 114 62.378 49.924 −13.020 1.00 17.96 B N ATOM 10264 CA VAL B 114 63.109 50.814 −13.915 1.00 17.72 B C ATOM 10266 CB VAL B 114 64.338 50.121 −14.540 1.00 17.40 B C ATOM 10268 CG1 VAL B 114 65.341 49.766 −13.458 1.00 16.56 B C ATOM 10272 CG2 VAL B 114 63.925 48.880 −15.324 1.00 17.16 B C ATOM 10276 C VAL B 114 62.152 51.303 −15.005 1.00 17.86 B C ATOM 10277 O VAL B 114 61.067 50.746 −15.183 1.00 17.45 B O ATOM 10279 N SER B 115 62.554 52.351 −15.719 1.00 18.11 B N ATOM 10280 CA SER B 115 61.695 52.993 −16.713 1.00 17.98 B C ATOM 10282 CB SER B 115 61.151 54.311 −16.155 1.00 17.76 B C ATOM 10285 OG SER B 115 60.269 54.934 −17.070 1.00 17.43 B O ATOM 10287 C SER B 115 62.451 53.247 −18.016 1.00 18.09 B C ATOM 10288 O SER B 115 63.661 53.487 −18.006 1.00 18.38 B O ATOM 10290 N GLN B 116 61.724 53.199 −19.132 1.00 17.77 B N ATOM 10291 CA GLN B 116 62.300 53.431 −20.460 1.00 17.40 B C ATOM 10293 CB GLN B 116 61.235 53.251 −21.548 1.00 17.53 B C ATOM 10296 CG GLN B 116 60.133 54.317 −21.543 1.00 18.28 B C ATOM 10299 CD GLN B 116 58.938 53.944 −22.404 1.00 17.36 B C ATOM 10300 OE1 GLN B 116 59.065 53.210 −23.385 1.00 17.59 B O ATOM 10301 NE2 GLN B 116 57.770 54.456 −22.041 1.00 15.98 B N ATOM 10304 C GLN B 116 62.944 54.812 −20.589 1.00 17.28 B C ATOM 10305 O GLN B 116 63.751 55.035 −21.488 1.00 17.66 B O ATOM 10307 N GLU B 117 62.586 55.731 −19.693 1.00 17.24 B N ATOM 10308 CA GLU B 117 63.225 57.050 −19.625 1.00 17.35 B C ATOM 10310 CB GLU B 117 62.455 57.969 −18.666 1.00 17.33 B C ATOM 10313 CG GLU B 117 61.062 58.369 −19.160 1.00 16.64 B C ATOM 10316 CD GLU B 117 61.092 59.306 −20.364 1.00 15.94 B C ATOM 10317 OE1 GLU B 117 62.165 59.872 −20.667 1.00 13.31 B O ATOM 10318 OE2 GLU B 117 60.034 59.479 −21.008 1.00 15.83 B O ATOM 10319 C GLU B 117 64.706 56.987 −19.218 1.00 17.41 B C ATOM 10320 O GLU B 117 65.398 58.005 −19.230 1.00 17.10 B O ATOM 10322 N ALA B 118 65.184 55.799 −18.848 1.00 17.79 B N ATOM 10323 CA ALA B 118 66.614 55.563 −18.667 1.00 18.07 B C ATOM 10325 CB ALA B 118 66.852 54.162 −18.121 1.00 17.97 B C ATOM 10329 C ALA B 118 67.360 55.748 −19.986 1.00 18.33 B C ATOM 10330 O ALA B 118 68.491 56.234 −20.004 1.00 18.49 B O ATOM 10332 N PHE B 119 66.711 55.369 −21.085 1.00 18.76 B N ATOM 10333 CA PHE B 119 67.313 55.448 −22.414 1.00 19.32 B C ATOM 10335 CB PHE B 119 66.785 54.310 −23.300 1.00 19.27 B C ATOM 10338 CG PHE B 119 67.039 52.933 −22.742 1.00 18.34 B C ATOM 10339 CD1 PHE B 119 65.987 52.138 −22.305 1.00 17.02 B C ATOM 10341 CE1 PHE B 119 66.219 50.871 −21.791 1.00 17.25 B C ATOM 10343 CZ PHE B 119 67.514 50.384 −21.706 1.00 17.67 B C ATOM 10345 CE2 PHE B 119 68.574 51.166 −22.137 1.00 17.65 B C ATOM 10347 CD2 PHE B 119 68.333 52.433 −22.653 1.00 18.36 B C ATOM 10349 C PHE B 119 67.075 56.794 −23.114 1.00 20.18 B C ATOM 10350 O PHE B 119 67.387 56.933 −24.298 1.00 20.87 B O ATOM 10352 N SER B 120 66.537 57.781 −22.396 1.00 20.76 B N ATOM 10353 CA SER B 120 66.253 59.099 −22.982 1.00 20.91 B C ATOM 10355 CB SER B 120 65.240 59.870 −22.129 1.00 20.93 B C ATOM 10358 OG SER B 120 65.837 60.372 −20.944 1.00 21.26 B O ATOM 10360 C SER B 120 67.515 59.945 −23.177 1.00 20.98 B C ATOM 10361 O SER B 120 67.497 60.912 −23.937 1.00 21.13 B O ATOM 10363 N GLY B 121 68.601 59.584 −22.496 1.00 21.23 B N ATOM 10364 CA GLY B 121 69.884 60.267 −22.667 1.00 21.73 B C ATOM 10367 C GLY B 121 70.734 59.725 −23.808 1.00 22.23 B C ATOM 10368 O GLY B 121 71.951 59.924 −23.821 1.00 21.96 B O ATOM 10370 N PHE B 122 70.098 59.038 −24.762 1.00 22.81 B N ATOM 10371 CA PHE B 122 70.789 58.447 −25.913 1.00 23.32 B C ATOM 10373 CB PHE B 122 71.029 56.945 −25.680 1.00 23.17 B C ATOM 10376 CG PHE B 122 71.721 56.627 −24.382 1.00 22.98 B C ATOM 10377 CD1 PHE B 122 73.108 56.588 −24.308 1.00 22.49 B C ATOM 10379 CE1 PHE B 122 73.750 56.293 −23.107 1.00 22.39 B C ATOM 10381 CZ PHE B 122 73.002 56.034 −21.968 1.00 22.47 B C ATOM 10383 CE2 PHE B 122 71.617 56.067 −22.030 1.00 23.14 B C ATOM 10385 CD2 PHE B 122 70.984 56.361 −23.234 1.00 23.30 B C ATOM 10387 C PHE B 122 69.984 58.640 −27.204 1.00 23.76 B C ATOM 10388 O PHE B 122 69.948 57.751 −28.056 1.00 23.82 B O ATOM 10390 N LYS B 123 69.348 59.803 −27.349 1.00 24.39 B N ATOM 10391 CA LYS B 123 68.464 60.075 −28.490 1.00 24.99 B C ATOM 10393 CB LYS B 123 66.996 59.960 −28.061 1.00 25.11 B C ATOM 10396 CG LYS B 123 66.579 58.554 −27.623 1.00 26.36 B C ATOM 10399 CD LYS B 123 65.256 58.547 −26.858 1.00 27.49 B C ATOM 10402 CE LYS B 123 64.056 58.691 −27.782 1.00 28.01 B C ATOM 10405 NZ LYS B 123 63.822 57.472 −28.611 1.00 28.15 B N ATOM 10409 C LYS B 123 68.728 61.456 −29.106 1.00 25.23 B C ATOM 10410 O LYS B 123 68.984 62.428 −28.391 1.00 25.22 B O ATOM 10412 N ASP B 124 68.647 61.529 −30.435 1.00 25.37 B N ATOM 10413 CA ASP B 124 68.960 62.755 −31.185 1.00 25.33 B C ATOM 10415 CB ASP B 124 69.203 62.423 −32.673 1.00 25.38 B C ATOM 10418 CG ASP B 124 67.946 61.934 −33.398 1.00 24.90 B C ATOM 10419 OD1 ASP B 124 66.838 61.988 −32.824 1.00 23.59 B O ATOM 10420 OD2 ASP B 124 68.072 61.489 −34.558 1.00 23.99 B O ATOM 10421 C ASP B 124 67.882 63.840 −31.028 1.00 25.30 B C ATOM 10422 O ASP B 124 66.943 63.683 −30.243 1.00 25.33 B O ATOM 10424 N GLN B 125 68.032 64.938 −31.770 1.00 25.13 B N ATOM 10425 CA GLN B 125 67.047 66.026 −31.767 1.00 25.14 B C ATOM 10427 CB GLN B 125 67.458 67.128 −32.750 1.00 25.16 B C ATOM 10430 CG GLN B 125 68.471 68.123 −32.187 1.00 25.92 B C ATOM 10433 CD GLN B 125 67.855 69.137 −31.228 1.00 25.99 B C ATOM 10434 OE1 GLN B 125 66.688 69.032 −30.849 1.00 26.31 B O ATOM 10435 NE2 GLN B 125 68.646 70.126 −30.832 1.00 25.52 B N ATOM 10438 C GLN B 125 65.633 65.545 −32.098 1.00 25.09 B C ATOM 10439 O GLN B 125 64.675 65.901 −31.409 1.00 25.17 B O ATOM 10441 N ASN B 126 65.511 64.738 −33.149 1.00 24.90 B N ATOM 10442 CA ASN B 126 64.213 64.199 −33.567 1.00 24.53 B C ATOM 10444 CB ASN B 126 64.337 63.471 −34.911 1.00 24.47 B C ATOM 10447 CG ASN B 126 64.510 64.422 −36.078 1.00 24.13 B C ATOM 10448 OD1 ASN B 126 65.064 65.511 −35.930 1.00 23.55 B O ATOM 10449 ND2 ASN B 126 64.033 64.015 −37.249 1.00 23.27 B N ATOM 10452 C ASN B 126 63.578 63.257 −32.545 1.00 24.35 B C ATOM 10453 O ASN B 126 62.352 63.204 −32.430 1.00 24.38 B O ATOM 10455 N GLY B 127 64.411 62.524 −31.808 1.00 23.98 B N ATOM 10456 CA GLY B 127 63.938 61.494 −30.881 1.00 23.80 B C ATOM 10459 C GLY B 127 64.216 60.076 −31.357 1.00 23.59 B C ATOM 10460 O GLY B 127 63.608 59.124 −30.865 1.00 23.44 B O ATOM 10462 N ASN B 128 65.117 59.939 −32.330 1.00 23.46 B N ATOM 10463 CA ASN B 128 65.661 58.641 −32.721 1.00 23.17 B C ATOM 10465 CB ASN B 128 65.918 58.577 −34.232 1.00 23.19 B C ATOM 10468 CG ASN B 128 64.713 59.001 −35.056 1.00 22.48 B C ATOM 10469 OD1 ASN B 128 64.149 60.075 −34.846 1.00 20.86 B O ATOM 10470 ND2 ASN B 128 64.323 58.162 −36.010 1.00 21.21 B N ATOM 10473 C ASN B 128 66.972 58.432 −31.980 1.00 22.97 B C ATOM 10474 O ASN B 128 67.583 59.394 −31.515 1.00 22.71 B O ATOM 10476 N PHE B 129 67.408 57.182 −31.870 1.00 22.94 B N ATOM 10477 CA PHE B 129 68.691 56.885 −31.234 1.00 22.94 B C ATOM 10479 CB PHE B 129 68.859 55.380 −31.017 1.00 23.04 B C ATOM 10482 CG PHE B 129 68.061 54.844 −29.863 1.00 24.12 B C ATOM 10483 CD1 PHE B 129 66.708 54.559 −30.011 1.00 25.06 B C ATOM 10485 CE1 PHE B 129 65.965 54.066 −28.946 1.00 25.61 B C ATOM 10487 CZ PHE B 129 66.575 53.850 −27.718 1.00 25.88 B C ATOM 10489 CE2 PHE B 129 67.926 54.130 −27.559 1.00 25.30 B C ATOM 10491 CD2 PHE B 129 68.661 54.625 −28.628 1.00 24.47 B C ATOM 10493 C PHE B 129 69.827 57.432 −32.091 1.00 22.78 B C ATOM 10494 O PHE B 129 69.719 57.474 −33.320 1.00 22.90 B O ATOM 10496 N LEU B 130 70.907 57.862 −31.441 1.00 22.49 B N ATOM 10497 CA LEU B 130 72.045 58.435 −32.154 1.00 22.33 B C ATOM 10499 CB LEU B 130 73.095 58.980 −31.178 1.00 22.14 B C ATOM 10502 CG LEU B 130 72.731 60.262 −30.422 1.00 21.49 B C ATOM 10504 CD1 LEU B 130 73.833 60.628 −29.442 1.00 20.84 B C ATOM 10508 CD2 LEU B 130 72.469 61.414 −31.383 1.00 20.96 B C ATOM 10512 C LEU B 130 72.672 57.393 −33.075 1.00 22.54 B C ATOM 10513 O LEU B 130 73.072 56.320 −32.626 1.00 22.34 B O ATOM 10515 N GLU B 131 72.730 57.721 −34.365 1.00 23.02 B N ATOM 10516 CA GLU B 131 73.337 56.863 −35.387 1.00 23.37 B C ATOM 10518 CB GLU B 131 73.410 57.629 −36.718 1.00 23.40 B C ATOM 10521 CG GLU B 131 74.128 56.913 −37.870 1.00 24.01 B C ATOM 10524 CD GLU B 131 73.300 55.813 −38.517 1.00 25.54 B C ATOM 10525 OE1 GLU B 131 72.271 55.395 −37.939 1.00 26.84 B O ATOM 10526 OE2 GLU B 131 73.688 55.362 −39.616 1.00 26.70 B O ATOM 10527 C GLU B 131 74.732 56.388 −34.976 1.00 23.61 B C ATOM 10528 O GLU B 131 75.065 55.213 −35.130 1.00 23.84 B O ATOM 10530 N ASN B 132 75.531 57.306 −34.438 1.00 23.67 B N ATOM 10531 CA ASN B 132 76.923 57.024 −34.060 1.00 23.74 B C ATOM 10533 CB ASN B 132 77.674 58.343 −33.806 1.00 23.96 B C ATOM 10536 CG ASN B 132 76.916 59.285 −32.884 1.00 24.66 B C ATOM 10537 OD1 ASN B 132 76.613 58.945 −31.739 1.00 25.44 B O ATOM 10538 ND2 ASN B 132 76.604 60.477 −33.384 1.00 24.88 B N ATOM 10541 C ASN B 132 77.118 56.056 −32.873 1.00 23.55 B C ATOM 10542 O ASN B 132 78.253 55.791 −32.469 1.00 23.42 B O ATOM 10544 N LEU B 133 76.022 55.535 −32.322 1.00 23.55 B N ATOM 10545 CA LEU B 133 76.087 54.480 −31.303 1.00 23.52 B C ATOM 10547 CB LEU B 133 74.870 54.555 −30.370 1.00 23.31 B C ATOM 10550 CG LEU B 133 74.750 55.823 −29.521 1.00 22.53 B C ATOM 10552 CD1 LEU B 133 73.383 55.904 −28.862 1.00 20.74 B C ATOM 10556 CD2 LEU B 133 75.857 55.886 −28.477 1.00 22.10 B C ATOM 10560 C LEU B 133 76.180 53.075 −31.916 1.00 23.65 B C ATOM 10561 O LEU B 133 76.404 52.102 −31.193 1.00 23.81 B O ATOM 10563 N LYS B 134 76.011 52.970 −33.237 1.00 23.51 B N ATOM 10564 CA LYS B 134 76.111 51.681 −33.931 1.00 23.40 B C ATOM 10566 CB LYS B 134 75.613 51.790 −35.382 1.00 23.26 B C ATOM 10569 CG LYS B 134 76.593 52.452 −36.356 1.00 23.29 B C ATOM 10572 CD LYS B 134 76.009 52.566 −37.761 1.00 22.10 B C ATOM 10575 CE LYS B 134 77.047 53.064 −38.759 1.00 20.46 B C ATOM 10578 NZ LYS B 134 76.503 53.139 −40.141 1.00 18.74 B N ATOM 10582 C LYS B 134 77.539 51.126 −33.907 1.00 23.60 B C ATOM 10583 O LYS B 134 77.736 49.915 −34.006 1.00 23.60 B O ATOM 10585 N GLU B 135 78.525 52.014 −33.780 1.00 23.90 B N ATOM 10586 CA GLU B 135 79.934 51.615 −33.743 1.00 24.13 B C ATOM 10588 CB GLU B 135 80.853 52.842 −33.837 1.00 24.42 B C ATOM 10591 CG GLU B 135 80.740 53.633 −35.149 1.00 25.24 B C ATOM 10594 CD GLU B 135 81.137 52.832 −36.384 1.00 25.99 B C ATOM 10595 OE1 GLU B 135 81.957 51.895 −36.266 1.00 25.85 B O ATOM 10596 OE2 GLU B 135 80.629 53.148 −37.482 1.00 26.38 B O ATOM 10597 C GLU B 135 80.275 50.800 −32.493 1.00 23.93 B C ATOM 10598 O GLU B 135 81.150 49.934 −32.542 1.00 24.05 B O ATOM 10600 N ASP B 136 79.596 51.078 −31.382 1.00 23.74 B N ATOM 10601 CA ASP B 136 79.752 50.270 −30.172 1.00 23.80 B C ATOM 10603 CB ASP B 136 79.424 51.090 −28.914 1.00 23.79 B C ATOM 10606 CG ASP B 136 80.046 50.506 −27.647 1.00 23.69 B C ATOM 10607 OD1 ASP B 136 80.288 49.280 −27.589 1.00 22.19 B O ATOM 10608 OD2 ASP B 136 80.295 51.282 −26.701 1.00 24.10 B O ATOM 10609 C ASP B 136 78.855 49.031 −30.280 1.00 23.77 B C ATOM 10610 O ASP B 136 77.667 49.080 −29.957 1.00 23.85 B O ATOM 10612 N ILE B 137 79.438 47.927 −30.743 1.00 23.58 B N ATOM 10613 CA ILE B 137 78.701 46.674 −30.945 1.00 23.48 B C ATOM 10615 CB ILE B 137 79.553 45.638 −31.734 1.00 23.47 B C ATOM 10617 CG1 ILE B 137 79.750 46.086 −33.189 1.00 23.86 B C ATOM 10620 CD1 ILE B 137 80.947 46.990 −33.413 1.00 23.96 B C ATOM 10624 CG2 ILE B 137 78.900 44.261 −31.712 1.00 23.85 B C ATOM 10628 C ILE B 137 78.242 46.065 −29.612 1.00 23.33 B C ATOM 10629 O ILE B 137 77.241 45.344 −29.559 1.00 23.33 B O ATOM 10631 N LYS B 138 78.974 46.368 −28.543 1.00 22.92 B N ATOM 10632 CA LYS B 138 78.647 45.884 −27.202 1.00 22.45 B C ATOM 10634 CB LYS B 138 79.815 46.177 −26.252 1.00 22.66 B C ATOM 10637 CG LYS B 138 80.011 45.168 −25.136 1.00 23.58 B C ATOM 10640 CD LYS B 138 80.951 45.726 −24.063 1.00 25.04 B C ATOM 10643 CE LYS B 138 81.815 44.644 −23.430 1.00 25.73 B C ATOM 10646 NZ LYS B 138 82.936 44.235 −24.324 1.00 25.22 B N ATOM 10650 C LYS B 138 77.364 46.542 −26.673 1.00 21.59 B C ATOM 10651 O LYS B 138 76.492 45.864 −26.123 1.00 21.40 B O ATOM 10653 N ALA B 139 77.258 47.860 −26.853 1.00 20.48 B N ATOM 10654 CA ALA B 139 76.130 48.643 −26.335 1.00 19.64 B C ATOM 10656 CB ALA B 139 76.479 50.125 −26.324 1.00 19.54 B C ATOM 10660 C ALA B 139 74.841 48.416 −27.118 1.00 19.12 B C ATOM 10661 O ALA B 139 73.756 48.368 −26.535 1.00 19.04 B O ATOM 10663 N ILE B 140 74.961 48.292 −28.437 1.00 18.59 B N ATOM 10664 CA ILE B 140 73.814 47.982 −29.291 1.00 18.11 B C ATOM 10666 CB ILE B 140 74.197 47.979 −30.791 1.00 18.07 B C ATOM 10668 CG1 ILE B 140 74.613 49.380 −31.254 1.00 18.28 B C ATOM 10671 CD1 ILE B 140 73.475 50.378 −31.350 1.00 18.35 B C ATOM 10675 CG2 ILE B 140 73.040 47.471 −31.646 1.00 17.81 B C ATOM 10679 C ILE B 140 73.234 46.614 −28.928 1.00 17.72 B C ATOM 10680 O ILE B 140 72.017 46.443 −28.889 1.00 18.01 B O ATOM 10682 N LEU B 141 74.108 45.648 −28.657 1.00 17.08 B N ATOM 10683 CA LEU B 141 73.674 44.295 −28.331 1.00 16.61 B C ATOM 10685 CB LEU B 141 74.854 43.324 −28.386 1.00 16.26 B C ATOM 10688 CG LEU B 141 74.528 41.828 −28.324 1.00 15.01 B C ATOM 10690 CD1 LEU B 141 73.243 41.487 −29.069 1.00 13.84 B C ATOM 10694 CD2 LEU B 141 75.696 41.020 −28.873 1.00 14.21 B C ATOM 10698 C LEU B 141 73.003 44.233 −26.963 1.00 16.78 B C ATOM 10699 O LEU B 141 71.933 43.640 −26.820 1.00 17.29 B O ATOM 10701 N SER B 142 73.624 44.843 −25.958 1.00 16.60 B N ATOM 10702 CA SER B 142 73.015 44.911 −24.627 1.00 16.64 B C ATOM 10704 CB SER B 142 73.944 45.607 −23.625 1.00 16.83 B C ATOM 10707 OG SER B 142 74.964 44.727 −23.179 1.00 16.19 B O ATOM 10709 C SER B 142 71.659 45.621 −24.692 1.00 16.43 B C ATOM 10710 O SER B 142 70.700 45.194 −24.048 1.00 16.17 B O ATOM 10712 N LEU B 143 71.589 46.697 −25.474 1.00 16.32 B N ATOM 10713 CA LEU B 143 70.322 47.380 −25.743 1.00 16.29 B C ATOM 10715 CB LEU B 143 70.539 48.590 −26.664 1.00 15.94 B C ATOM 10718 CG LEU B 143 69.296 49.191 −27.331 1.00 15.20 B C ATOM 10720 CD1 LEU B 143 68.240 49.558 −26.301 1.00 13.55 B C ATOM 10724 CD2 LEU B 143 69.678 50.402 −28.160 1.00 15.26 B C ATOM 10728 C LEU B 143 69.312 46.415 −26.365 1.00 16.70 B C ATOM 10729 O LEU B 143 68.150 46.375 −25.957 1.00 17.42 B O ATOM 10731 N TYR B 144 69.765 45.644 −27.350 1.00 16.53 B N ATOM 10732 CA TYR B 144 68.921 44.657 −28.024 1.00 16.27 B C ATOM 10734 CB TYR B 144 69.718 43.942 −29.118 1.00 16.16 B C ATOM 10737 CG TYR B 144 69.051 42.714 −29.692 1.00 15.78 B C ATOM 10738 CD1 TYR B 144 67.955 42.822 −30.541 1.00 15.10 B C ATOM 10740 CE1 TYR B 144 67.349 41.697 −31.077 1.00 14.61 B C ATOM 10742 CZ TYR B 144 67.844 40.447 −30.769 1.00 15.60 B C ATOM 10743 OH TYR B 144 67.251 39.325 −31.297 1.00 19.22 B O ATOM 10745 CE2 TYR B 144 68.933 40.314 −29.932 1.00 16.86 B C ATOM 10747 CD2 TYR B 144 69.531 41.444 −29.401 1.00 16.55 B C ATOM 10749 C TYR B 144 68.336 43.641 −27.046 1.00 16.32 B C ATOM 10750 O TYR B 144 67.143 43.348 −27.094 1.00 16.33 B O ATOM 10752 N GLU B 145 69.178 43.116 −26.159 1.00 16.42 B N ATOM 10753 CA GLU B 145 68.738 42.136 −25.162 1.00 16.72 B C ATOM 10755 CB GLU B 145 69.940 41.586 −24.382 1.00 16.57 B C ATOM 10758 CG GLU B 145 70.940 40.787 −25.221 1.00 16.50 B C ATOM 10761 CD GLU B 145 70.436 39.406 −25.610 1.00 16.57 B C ATOM 10762 OE1 GLU B 145 69.275 39.069 −25.290 1.00 17.83 B O ATOM 10763 OE2 GLU B 145 71.208 38.652 −26.240 1.00 16.22 B O ATOM 10764 C GLU B 145 67.718 42.732 −24.184 1.00 16.86 B C ATOM 10765 O GLU B 145 66.768 42.055 −23.773 1.00 16.50 B O ATOM 10767 N ALA B 146 67.918 44.004 −23.832 1.00 16.74 B N ATOM 10768 CA ALA B 146 67.088 44.687 −22.838 1.00 16.36 B C ATOM 10770 CB ALA B 146 67.859 45.847 −22.219 1.00 15.89 B C ATOM 10774 C ALA B 146 65.760 45.187 −23.402 1.00 16.26 B C ATOM 10775 O ALA B 146 64.922 45.683 −22.650 1.00 16.44 B O ATOM 10777 N SER B 147 65.568 45.064 −24.713 1.00 16.21 B N ATOM 10778 CA SER B 147 64.326 45.496 −25.354 1.00 16.38 B C ATOM 10780 CB SER B 147 64.536 45.662 −26.862 1.00 16.51 B C ATOM 10783 OG SER B 147 64.814 44.420 −27.489 1.00 17.36 B O ATOM 10785 C SER B 147 63.163 44.531 −25.096 1.00 16.24 B C ATOM 10786 O SER B 147 62.015 44.959 −24.969 1.00 15.95 B O ATOM 10788 N PHE B 148 63.467 43.237 −25.009 1.00 16.34 B N ATOM 10789 CA PHE B 148 62.435 42.198 −24.890 1.00 16.34 B C ATOM 10791 CB PHE B 148 63.026 40.816 −25.190 1.00 16.30 B C ATOM 10794 CG PHE B 148 63.444 40.640 −26.620 1.00 17.03 B C ATOM 10795 CD1 PHE B 148 62.570 40.093 −27.548 1.00 18.20 B C ATOM 10797 CE1 PHE B 148 62.948 39.938 −28.877 1.00 19.13 B C ATOM 10799 CZ PHE B 148 64.213 40.335 −29.287 1.00 18.33 B C ATOM 10801 CE2 PHE B 148 65.093 40.887 −28.369 1.00 17.95 B C ATOM 10803 CD2 PHE B 148 64.705 41.039 −27.044 1.00 17.59 B C ATOM 10805 C PHE B 148 61.738 42.187 −23.530 1.00 16.13 B C ATOM 10806 O PHE B 148 60.615 41.695 −23.415 1.00 15.72 B O ATOM 10808 N LEU B 149 62.391 42.750 −22.514 1.00 16.32 B N ATOM 10809 CA LEU B 149 61.811 42.840 −21.171 1.00 16.28 B C ATOM 10811 CB LEU B 149 62.910 43.001 −20.117 1.00 15.75 B C ATOM 10814 CG LEU B 149 63.883 41.829 −20.010 1.00 15.12 B C ATOM 10816 CD1 LEU B 149 65.018 41.960 −21.017 1.00 14.29 B C ATOM 10820 CD2 LEU B 149 64.430 41.725 −18.598 1.00 15.76 B C ATOM 10824 C LEU B 149 60.816 43.995 −21.049 1.00 16.79 B C ATOM 10825 O LEU B 149 60.382 44.327 −19.943 1.00 17.29 B O ATOM 10827 N ALA B 150 60.451 44.597 −22.182 1.00 16.76 B N ATOM 10828 CA ALA B 150 59.538 45.736 −22.205 1.00 16.50 B C ATOM 10830 CB ALA B 150 59.404 46.271 −23.627 1.00 16.43 B C ATOM 10834 C ALA B 150 58.163 45.397 −21.646 1.00 16.20 B C ATOM 10835 O ALA B 150 57.838 44.230 −21.406 1.00 15.98 B O ATOM 10837 N LEU B 151 57.368 46.440 −21.437 1.00 16.11 B N ATOM 10838 CA LEU B 151 55.992 46.298 −20.982 1.00 16.14 B C ATOM 10840 CB LEU B 151 55.809 46.980 −19.625 1.00 16.21 B C ATOM 10843 CG LEU B 151 56.718 46.502 −18.488 1.00 15.32 B C ATOM 10845 CD1 LEU B 151 56.599 47.436 −17.293 1.00 13.46 B C ATOM 10849 CD2 LEU B 151 56.397 45.066 −18.088 1.00 13.69 B C ATOM 10853 C LEU B 151 55.044 46.910 −22.008 1.00 16.00 B C ATOM 10854 O LEU B 151 55.475 47.599 −22.936 1.00 15.95 B O ATOM 10856 N GLU B 152 53.752 46.651 −21.830 1.00 15.76 B N ATOM 10857 CA GLU B 152 52.730 47.163 −22.734 1.00 15.95 B C ATOM 10859 CB GLU B 152 51.356 46.595 −22.363 1.00 16.09 B C ATOM 10862 CG GLU B 152 50.504 46.178 −23.560 1.00 17.01 B C ATOM 10865 CD GLU B 152 49.009 46.229 −23.277 1.00 17.41 B C ATOM 10866 OE1 GLU B 152 48.623 46.417 −22.103 1.00 17.43 B O ATOM 10867 OE2 GLU B 152 48.216 46.086 −24.233 1.00 17.21 B O ATOM 10868 C GLU B 152 52.700 48.689 −22.649 1.00 16.18 B C ATOM 10869 O GLU B 152 52.615 49.243 −21.554 1.00 16.81 B O ATOM 10871 N GLY B 153 52.789 49.362 −23.795 1.00 16.13 B N ATOM 10872 CA GLY B 153 52.784 50.828 −23.839 1.00 15.84 B C ATOM 10875 C GLY B 153 54.164 51.469 −23.884 1.00 15.69 B C ATOM 10876 O GLY B 153 54.307 52.590 −24.373 1.00 15.81 B O ATOM 10878 N GLU B 154 55.178 50.771 −23.374 1.00 15.51 B N ATOM 10879 CA GLU B 154 56.550 51.282 −23.382 1.00 15.70 B C ATOM 10881 CB GLU B 154 57.448 50.439 −22.467 1.00 15.97 B C ATOM 10884 CG GLU B 154 57.054 50.515 −20.994 1.00 16.22 B C ATOM 10887 CD GLU B 154 58.095 49.917 −20.062 1.00 15.63 B C ATOM 10888 OE1 GLU B 154 58.417 50.567 −19.046 1.00 12.92 B O ATOM 10889 OE2 GLU B 154 58.590 48.802 −20.341 1.00 16.00 B O ATOM 10890 C GLU B 154 57.105 51.317 −24.807 1.00 15.67 B C ATOM 10891 O GLU B 154 57.757 50.375 −25.262 1.00 15.68 B O ATOM 10893 N ASN B 155 56.843 52.423 −25.498 1.00 15.69 B N ATOM 10894 CA ASN B 155 57.164 52.547 −26.924 1.00 15.77 B C ATOM 10896 CB ASN B 155 56.417 53.741 −27.552 1.00 15.68 B C ATOM 10899 CG ASN B 155 56.741 55.074 −26.883 1.00 15.48 B C ATOM 10900 OD1 ASN B 155 57.898 55.377 −26.591 1.00 15.65 B O ATOM 10901 ND2 ASN B 155 55.711 55.882 −26.655 1.00 14.42 B N ATOM 10904 C ASN B 155 58.661 52.613 −27.260 1.00 15.85 B C ATOM 10905 O ASN B 155 59.062 52.208 −28.351 1.00 16.36 B O ATOM 10907 N ILE B 156 59.478 53.117 −26.335 1.00 15.40 B N ATOM 10908 CA ILE B 156 60.903 53.345 −26.610 1.00 14.84 B C ATOM 10910 CB ILE B 156 61.565 54.261 −25.548 1.00 14.77 B C ATOM 10912 CG1 ILE B 156 60.846 55.612 −25.479 1.00 14.33 B C ATOM 10915 CD1 ILE B 156 61.588 56.669 −24.686 1.00 13.21 B C ATOM 10919 CG2 ILE B 156 63.038 54.486 −25.870 1.00 14.12 B C ATOM 10923 C ILE B 156 61.690 52.037 −26.718 1.00 14.66 B C ATOM 10924 O ILE B 156 62.621 51.939 −27.516 1.00 14.69 B O ATOM 10926 N LEU B 157 61.319 51.038 −25.922 1.00 14.65 B N ATOM 10927 CA LEU B 157 61.992 49.735 −25.974 1.00 14.75 B C ATOM 10929 CB LEU B 157 61.576 48.846 −24.796 1.00 14.48 B C ATOM 10932 CG LEU B 157 62.394 49.043 −23.516 1.00 13.97 B C ATOM 10934 CD1 LEU B 157 62.541 50.515 −23.164 1.00 15.30 B C ATOM 10938 CD2 LEU B 157 61.766 48.288 −22.364 1.00 13.93 B C ATOM 10942 C LEU B 157 61.744 49.022 −27.306 1.00 15.28 B C ATOM 10943 O LEU B 157 62.644 48.368 −27.832 1.00 15.56 B O ATOM 10945 N ASP B 158 60.536 49.158 −27.849 1.00 15.69 B N ATOM 10946 CA ASP B 158 60.230 48.641 −29.184 1.00 16.04 B C ATOM 10948 CB ASP B 158 58.766 48.888 −29.546 1.00 16.00 B C ATOM 10951 CG ASP B 158 57.807 48.095 −28.682 1.00 17.24 B C ATOM 10952 OD1 ASP B 158 58.224 47.607 −27.609 1.00 19.56 B O ATOM 10953 OD2 ASP B 158 56.630 47.963 −29.081 1.00 17.24 B O ATOM 10954 C ASP B 158 61.127 49.307 −30.222 1.00 16.55 B C ATOM 10955 O ASP B 158 61.746 48.625 −31.041 1.00 16.41 B O ATOM 10957 N GLU B 159 61.192 50.640 −30.171 1.00 17.24 B N ATOM 10958 CA GLU B 159 62.070 51.427 −31.045 1.00 17.47 B C ATOM 10960 CB GLU B 159 61.967 52.923 −30.728 1.00 17.55 B C ATOM 10963 CG GLU B 159 60.630 53.563 −31.057 1.00 19.36 B C ATOM 10966 CD GLU B 159 60.517 54.982 −30.511 1.00 22.03 B C ATOM 10967 OE1 GLU B 159 61.422 55.804 −30.782 1.00 21.37 B O ATOM 10968 OE2 GLU B 159 59.522 55.273 −29.812 1.00 23.93 B O ATOM 10969 C GLU B 159 63.522 50.995 −30.887 1.00 17.46 B C ATOM 10970 O GLU B 159 64.280 50.984 −31.856 1.00 17.74 B O ATOM 10972 N ALA B 160 63.900 50.651 −29.656 1.00 17.33 B N ATOM 10973 CA ALA B 160 65.238 50.152 −29.361 1.00 17.26 B C ATOM 10975 CB ALA B 160 65.405 49.946 −27.866 1.00 17.19 B C ATOM 10979 C ALA B 160 65.517 48.852 −30.105 1.00 17.27 B C ATOM 10980 O ALA B 160 66.602 48.671 −30.658 1.00 17.36 B O ATOM 10982 N LYS B 161 64.534 47.955 −30.121 1.00 17.28 B N ATOM 10983 CA LYS B 161 64.679 46.673 −30.806 1.00 17.64 B C ATOM 10985 CB LYS B 161 63.488 45.756 −30.499 1.00 17.92 B C ATOM 10988 CG LYS B 161 63.630 44.332 −31.034 1.00 18.60 B C ATOM 10991 CD LYS B 161 62.821 43.311 −30.222 1.00 19.37 B C ATOM 10994 CE LYS B 161 61.331 43.648 −30.151 1.00 19.94 B C ATOM 10997 NZ LYS B 161 60.535 42.535 −29.550 1.00 19.72 B N ATOM 11001 C LYS B 161 64.827 46.884 −32.311 1.00 17.64 B C ATOM 11002 O LYS B 161 65.773 46.387 −32.921 1.00 17.55 B O ATOM 11004 N VAL B 162 63.904 47.644 −32.897 1.00 17.74 B N ATOM 11005 CA VAL B 162 63.945 47.954 −34.331 1.00 17.76 B C ATOM 11007 CB VAL B 162 62.713 48.788 −34.770 1.00 17.61 B C ATOM 11009 CG1 VAL B 162 62.847 49.240 −36.220 1.00 16.32 B C ATOM 11013 CG2 VAL B 162 61.435 47.983 −34.579 1.00 17.55 B C ATOM 11017 C VAL B 162 65.231 48.697 −34.713 1.00 17.95 B C ATOM 11018 O VAL B 162 65.733 48.540 −35.829 1.00 18.42 B O ATOM 11020 N PHE B 163 65.760 49.491 −33.783 1.00 17.79 B N ATOM 11021 CA PHE B 163 66.995 50.244 −34.008 1.00 17.65 B C ATOM 11023 CB PHE B 163 67.121 51.380 −32.985 1.00 17.30 B C ATOM 11026 CG PHE B 163 68.412 52.132 −33.073 1.00 15.04 B C ATOM 11027 CD1 PHE B 163 68.578 53.138 −34.008 1.00 14.91 B C ATOM 11029 CE1 PHE B 163 69.773 53.832 −34.095 1.00 15.53 B C ATOM 11031 CZ PHE B 163 70.819 53.520 −33.238 1.00 14.60 B C ATOM 11033 CE2 PHE B 163 70.664 52.517 −32.305 1.00 13.99 B C ATOM 11035 CD2 PHE B 163 69.467 51.827 −32.227 1.00 13.98 B C ATOM 11037 C PHE B 163 68.245 49.360 −33.958 1.00 18.10 B C ATOM 11038 O PHE B 163 69.188 49.574 −34.722 1.00 18.08 B O ATOM 11040 N ALA B 164 68.256 48.381 −33.055 1.00 18.58 B N ATOM 11041 CA ALA B 164 69.415 47.502 −32.882 1.00 18.87 B C ATOM 11043 CB ALA B 164 69.362 46.814 −31.532 1.00 18.67 B C ATOM 11047 C ALA B 164 69.499 46.467 −33.999 1.00 19.36 B C ATOM 11048 O ALA B 164 70.548 46.304 −34.616 1.00 19.42 B O ATOM 11050 N ILE B 165 68.386 45.783 −34.258 1.00 20.22 B N ATOM 11051 CA ILE B 165 68.322 44.739 −35.290 1.00 20.91 B C ATOM 11053 CB ILE B 165 66.900 44.120 −35.396 1.00 21.06 B C ATOM 11055 CG1 ILE B 165 66.529 43.370 −34.114 1.00 20.91 B C ATOM 11058 CD1 ILE B 165 65.107 42.851 −34.110 1.00 21.56 B C ATOM 11062 CG2 ILE B 165 66.810 43.158 −36.577 1.00 21.26 B C ATOM 11066 C ILE B 165 68.732 45.267 −36.668 1.00 21.49 B C ATOM 11067 O ILE B 165 69.319 44.533 −37.466 1.00 21.69 B O ATOM 11069 N SER B 166 68.419 46.533 −36.941 1.00 22.01 B N ATOM 11070 CA SER B 166 68.784 47.169 −38.210 1.00 22.52 B C ATOM 11072 CB SER B 166 68.144 48.560 −38.322 1.00 22.55 B C ATOM 11075 OG SER B 166 68.720 49.477 −37.407 1.00 22.35 B O ATOM 11077 C SER B 166 70.302 47.274 −38.410 1.00 23.00 B C ATOM 11078 O SER B 166 70.782 47.188 −39.542 1.00 23.31 B O ATOM 11080 N HIS B 167 71.044 47.460 −37.317 1.00 23.34 B N ATOM 11081 CA HIS B 167 72.509 47.582 −37.372 1.00 23.44 B C ATOM 11083 CB HIS B 167 73.004 48.652 −36.387 1.00 23.48 B C ATOM 11086 CG HIS B 167 72.718 50.058 −36.822 1.00 24.37 B C ATOM 11087 ND1 HIS B 167 72.058 50.966 −36.022 1.00 24.84 B N ATOM 11089 CE1 HIS B 167 71.949 52.117 −36.661 1.00 24.23 B C ATOM 11091 NE2 HIS B 167 72.513 51.988 −37.849 1.00 24.82 B N ATOM 11093 CD2 HIS B 167 73.001 50.710 −37.974 1.00 25.08 B C ATOM 11095 C HIS B 167 73.244 46.264 −37.103 1.00 23.24 B C ATOM 11096 O HIS B 167 74.377 46.095 −37.546 1.00 23.60 B O ATOM 11098 N LEU B 168 72.605 45.340 −36.387 1.00 22.97 B N ATOM 11099 CA LEU B 168 73.255 44.091 −35.967 1.00 22.95 B C ATOM 11101 CB LEU B 168 72.449 43.412 −34.852 1.00 22.93 B C ATOM 11104 CG LEU B 168 72.509 44.048 −33.460 1.00 22.05 B C ATOM 11106 CD1 LEU B 168 71.330 43.587 −32.619 1.00 20.71 B C ATOM 11110 CD2 LEU B 168 73.827 43.733 −32.766 1.00 20.14 B C ATOM 11114 C LEU B 168 73.462 43.089 −37.103 1.00 23.36 B C ATOM 11115 O LEU B 168 74.549 42.531 −37.249 1.00 23.26 B O ATOM 11117 N LYS B 169 72.418 42.855 −37.893 1.00 24.10 B N ATOM 11118 CA LYS B 169 72.433 41.778 −38.892 1.00 24.87 B C ATOM 11120 CB LYS B 169 71.002 41.350 −39.249 1.00 24.93 B C ATOM 11123 CG LYS B 169 70.192 42.360 −40.059 1.00 25.82 B C ATOM 11126 CD LYS B 169 68.686 42.102 −39.943 1.00 27.02 B C ATOM 11129 CE LYS B 169 68.291 40.714 −40.452 1.00 27.94 B C ATOM 11132 NZ LYS B 169 66.823 40.466 −40.352 1.00 27.64 B N ATOM 11136 C LYS B 169 73.231 42.100 −40.161 1.00 25.51 B C ATOM 11137 O LYS B 169 73.547 41.195 −40.937 1.00 25.25 B O ATOM 11139 N GLU B 170 73.564 43.376 −40.361 1.00 26.58 B N ATOM 11140 CA GLU B 170 74.350 43.809 −41.523 1.00 27.53 B C ATOM 11142 CB GLU B 170 73.806 45.137 −42.080 1.00 27.70 B C ATOM 11145 CG GLU B 170 72.272 45.219 −42.233 1.00 29.32 B C ATOM 11148 CD GLU B 170 71.704 44.349 −43.355 1.00 30.04 B C ATOM 11149 OE1 GLU B 170 72.480 43.674 −44.065 1.00 31.89 B O ATOM 11150 OE2 GLU B 170 70.467 44.347 −43.530 1.00 28.58 B O ATOM 11151 C GLU B 170 75.843 43.964 −41.181 1.00 27.95 B C ATOM 11152 O GLU B 170 76.540 44.784 −41.792 1.00 28.24 B O ATOM 11154 N LEU B 171 76.326 43.173 −40.217 1.00 27.99 B N ATOM 11155 CA LEU B 171 77.729 43.208 −39.791 1.00 27.86 B C ATOM 11157 CB LEU B 171 77.830 43.290 −38.264 1.00 27.64 B C ATOM 11160 CG LEU B 171 77.203 44.514 −37.588 1.00 26.91 B C ATOM 11162 CD1 LEU B 171 77.470 44.483 −36.088 1.00 24.62 B C ATOM 11166 CD2 LEU B 171 77.709 45.818 −38.197 1.00 25.86 B C ATOM 11170 C LEU B 171 78.485 41.976 −40.283 1.00 28.06 B C ATOM 11171 O LEU B 171 77.922 40.882 −40.362 1.00 27.83 B O ATOM 11173 N SER B 172 79.766 42.166 −40.595 1.00 28.45 B N ATOM 11174 CA SER B 172 80.616 41.104 −41.136 1.00 28.64 B C ATOM 11176 CB SER B 172 81.520 41.664 −42.237 1.00 28.62 B C ATOM 11179 OG SER B 172 82.445 40.690 −42.689 1.00 28.34 B O ATOM 11181 C SER B 172 81.476 40.461 −40.051 1.00 28.97 B C ATOM 11182 O SER B 172 81.869 41.120 −39.084 1.00 28.98 B O ATOM 11184 N GLU B 173 81.778 39.176 −40.232 1.00 29.33 B N ATOM 11185 CA GLU B 173 82.661 38.439 −39.323 1.00 29.65 B C ATOM 11187 CB GLU B 173 82.531 36.925 −39.553 1.00 29.65 B C ATOM 11190 CG GLU B 173 83.188 36.059 −38.471 1.00 30.47 B C ATOM 11193 CD GLU B 173 82.816 34.585 −38.567 1.00 31.62 B C ATOM 11194 OE1 GLU B 173 81.610 34.271 −38.670 1.00 31.50 B O ATOM 11195 OE2 GLU B 173 83.732 33.735 −38.523 1.00 31.84 B O ATOM 11196 C GLU B 173 84.126 38.882 −39.464 1.00 29.86 B C ATOM 11197 O GLU B 173 84.962 38.534 −38.630 1.00 30.01 B O ATOM 11199 N GLU B 174 84.435 39.639 −40.518 1.00 29.81 B N ATOM 11200 CA GLU B 174 85.760 40.244 −40.676 1.00 29.91 B C ATOM 11202 CB GLU B 174 86.107 40.423 −42.160 1.00 30.15 B C ATOM 11205 CG GLU B 174 86.698 39.179 −42.809 1.00 30.29 B C ATOM 11208 CD GLU B 174 86.767 39.283 −44.321 1.00 29.90 B C ATOM 11209 OE1 GLU B 174 87.889 39.316 −44.868 1.00 29.26 B O ATOM 11210 OE2 GLU B 174 85.697 39.339 −44.962 1.00 29.35 B O ATOM 11211 C GLU B 174 85.855 41.587 −39.950 1.00 29.71 B C ATOM 11212 O GLU B 174 86.787 41.810 −39.175 1.00 29.67 B O ATOM 11214 N LYS B 175 84.891 42.473 −40.205 1.00 29.47 B N ATOM 11215 CA LYS B 175 84.867 43.811 −39.595 1.00 29.30 B C ATOM 11217 CB LYS B 175 83.570 44.546 −39.944 1.00 29.60 B C ATOM 11220 CG LYS B 175 83.454 44.992 −41.390 1.00 30.58 B C ATOM 11223 CD LYS B 175 82.079 45.598 −41.651 1.00 31.84 B C ATOM 11226 CE LYS B 175 81.816 45.781 −43.136 1.00 32.09 B C ATOM 11229 NZ LYS B 175 80.394 46.124 −43.416 1.00 32.12 B N ATOM 11233 C LYS B 175 85.001 43.754 −38.076 1.00 28.77 B C ATOM 11234 O LYS B 175 85.642 44.612 −37.470 1.00 28.82 B O ATOM 11236 N ILE B 176 84.375 42.745 −37.476 1.00 28.19 B N ATOM 11237 CA ILE B 176 84.444 42.513 −36.034 1.00 27.82 B C ATOM 11239 CB ILE B 176 83.105 42.841 −35.331 1.00 27.95 B C ATOM 11241 CG1 ILE B 176 81.911 42.300 −36.132 1.00 27.44 B C ATOM 11244 CD1 ILE B 176 80.584 42.443 −35.424 1.00 26.82 B C ATOM 11248 CG2 ILE B 176 82.971 44.346 −35.137 1.00 28.50 B C ATOM 11252 C ILE B 176 84.834 41.061 −35.777 1.00 27.40 B C ATOM 11253 O ILE B 176 84.754 40.227 −36.675 1.00 27.29 B O ATOM 11255 N GLY B 177 85.249 40.767 −34.548 1.00 26.94 B N ATOM 11256 CA GLY B 177 85.791 39.452 −34.203 1.00 26.74 B C ATOM 11259 C GLY B 177 84.867 38.276 −34.467 1.00 26.46 B C ATOM 11260 O GLY B 177 83.648 38.434 −34.540 1.00 26.73 B O ATOM 11262 N LYS B 178 85.461 37.094 −34.618 1.00 26.15 B N ATOM 11263 CA LYS B 178 84.706 35.851 −34.767 1.00 25.92 B C ATOM 11265 CB LYS B 178 85.657 34.667 −34.967 1.00 25.77 B C ATOM 11268 CG LYS B 178 84.967 33.322 −35.183 1.00 25.80 B C ATOM 11271 CD LYS B 178 85.979 32.189 −35.296 1.00 25.76 B C ATOM 11274 CE LYS B 178 85.347 30.924 −35.863 1.00 25.07 B C ATOM 11277 NZ LYS B 178 86.333 29.818 −35.998 1.00 23.38 B N ATOM 11281 C LYS B 178 83.832 35.609 −33.538 1.00 26.02 B C ATOM 11282 O LYS B 178 82.671 35.214 −33.667 1.00 26.16 B O ATOM 11284 N GLU B 179 84.393 35.850 −32.353 1.00 25.87 B N ATOM 11285 CA GLU B 179 83.658 35.649 −31.099 1.00 25.72 B C ATOM 11287 CB GLU B 179 84.603 35.673 −29.881 1.00 25.81 B C ATOM 11290 CG GLU B 179 85.277 37.014 −29.571 1.00 26.23 B C ATOM 11293 CD GLU B 179 86.166 36.951 −28.330 1.00 26.14 B C ATOM 11294 OE1 GLU B 179 86.250 37.961 −27.601 1.00 25.98 B O ATOM 11295 OE2 GLU B 179 86.780 35.892 −28.077 1.00 25.53 B O ATOM 11296 C GLU B 179 82.509 36.649 −30.932 1.00 25.07 B C ATOM 11297 O GLU B 179 81.457 36.298 −30.397 1.00 24.79 B O ATOM 11299 N LEU B 180 82.712 37.881 −31.401 1.00 24.36 B N ATOM 11300 CA LEU B 180 81.663 38.904 −31.370 1.00 23.69 B C ATOM 11302 CB LEU B 180 82.253 40.300 −31.611 1.00 23.71 B C ATOM 11305 CG LEU B 180 81.387 41.489 −31.175 1.00 23.25 B C ATOM 11307 CD1 LEU B 180 81.356 41.608 −29.657 1.00 22.05 B C ATOM 11311 CD2 LEU B 180 81.892 42.785 −31.800 1.00 22.07 B C ATOM 11315 C LEU B 180 80.578 38.604 −32.407 1.00 23.13 B C ATOM 11316 O LEU B 180 79.404 38.903 −32.187 1.00 22.94 B O ATOM 11318 N ALA B 181 80.980 38.015 −33.533 1.00 22.63 B N ATOM 11319 CA ALA B 181 80.039 37.593 −34.573 1.00 22.38 B C ATOM 11321 CB ALA B 181 80.792 37.158 −35.819 1.00 22.13 B C ATOM 11325 C ALA B 181 79.138 36.459 −34.083 1.00 22.21 B C ATOM 11326 O ALA B 181 77.935 36.451 −34.347 1.00 22.14 B O ATOM 11328 N GLU B 182 79.732 35.506 −33.371 1.00 21.95 B N ATOM 11329 CA GLU B 182 79.000 34.349 −32.857 1.00 21.66 B C ATOM 11331 CB GLU B 182 79.979 33.284 −32.350 1.00 21.93 B C ATOM 11334 CG GLU B 182 80.709 32.557 −33.481 1.00 22.98 B C ATOM 11337 CD GLU B 182 81.913 31.751 −33.016 1.00 23.56 B C ATOM 11338 OE1 GLU B 182 82.298 31.861 −31.831 1.00 23.87 B O ATOM 11339 OE2 GLU B 182 82.477 31.005 −33.847 1.00 22.99 B O ATOM 11340 C GLU B 182 78.003 34.731 −31.762 1.00 20.94 B C ATOM 11341 O GLU B 182 76.949 34.107 −31.643 1.00 20.76 B O ATOM 11343 N GLN B 183 78.334 35.750 −30.972 1.00 20.28 B N ATOM 11344 CA GLN B 183 77.412 36.262 −29.957 1.00 20.01 B C ATOM 11346 CB GLN B 183 78.130 37.187 −28.968 1.00 19.95 B C ATOM 11349 CG GLN B 183 79.140 36.483 −28.068 1.00 20.86 B C ATOM 11352 CD GLN B 183 79.118 37.001 −26.638 1.00 22.16 B C ATOM 11353 OE1 GLN B 183 79.484 38.147 −26.375 1.00 22.85 B O ATOM 11354 NE2 GLN B 183 78.689 36.153 −25.707 1.00 21.77 B N ATOM 11357 C GLN B 183 76.234 36.999 −30.591 1.00 19.93 B C ATOM 11358 O GLN B 183 75.125 36.978 −30.052 1.00 19.93 B O ATOM 11360 N VAL B 184 76.477 37.651 −31.727 1.00 19.67 B N ATOM 11361 CA VAL B 184 75.416 38.334 −32.469 1.00 19.49 B C ATOM 11363 CB VAL B 184 75.991 39.266 −33.553 1.00 19.50 B C ATOM 11365 CG1 VAL B 184 76.767 40.403 −32.906 1.00 19.63 B C ATOM 11369 CG2 VAL B 184 74.880 39.815 −34.440 1.00 19.00 B C ATOM 11373 C VAL B 184 74.464 37.325 −33.111 1.00 19.48 B C ATOM 11374 O VAL B 184 73.246 37.484 −33.036 1.00 19.34 B O ATOM 11376 N ASN B 185 75.027 36.289 −33.732 1.00 19.56 B N ATOM 11377 CA ASN B 185 74.230 35.210 −34.323 1.00 19.71 B C ATOM 11379 CB ASN B 185 75.115 34.272 −35.153 1.00 19.76 B C ATOM 11382 CG ASN B 185 75.756 34.965 −36.348 1.00 20.50 B C ATOM 11383 OD1 ASN B 185 75.392 36.085 −36.706 1.00 22.61 B O ATOM 11384 ND2 ASN B 185 76.719 34.295 −36.971 1.00 21.21 B N ATOM 11387 C ASN B 185 73.473 34.402 −33.266 1.00 19.77 B C ATOM 11388 O ASN B 185 72.386 33.891 −33.533 1.00 20.02 B O ATOM 11390 N HIS B 186 74.057 34.287 −32.075 1.00 19.72 B N ATOM 11391 CA HIS B 186 73.404 33.628 −30.942 1.00 19.80 B C ATOM 11393 CB HIS B 186 74.414 33.411 −29.808 1.00 19.92 B C ATOM 11396 CG HIS B 186 73.854 32.703 −28.611 1.00 19.22 B C ATOM 11397 ND1 HIS B 186 73.549 31.358 −28.615 1.00 19.55 B N ATOM 11399 CE1 HIS B 186 73.091 31.010 −27.426 1.00 18.27 B C ATOM 11401 NE2 HIS B 186 73.093 32.077 −26.649 1.00 18.30 B N ATOM 11403 CD2 HIS B 186 73.571 33.149 −27.364 1.00 18.39 B C ATOM 11405 C HIS B 186 72.225 34.464 −30.448 1.00 19.84 B C ATOM 11406 O HIS B 186 71.124 33.943 −30.269 1.00 19.69 B O ATOM 11408 N ALA B 187 72.463 35.758 −30.240 1.00 19.89 B N ATOM 11409 CA ALA B 187 71.419 36.682 −29.780 1.00 19.70 B C ATOM 11411 CB ALA B 187 72.029 38.022 −29.387 1.00 19.58 B C ATOM 11415 C ALA B 187 70.320 36.886 −30.829 1.00 19.42 B C ATOM 11416 O ALA B 187 69.152 37.071 −30.477 1.00 19.51 B O ATOM 11418 N LEU B 188 70.693 36.853 −32.109 1.00 18.76 B N ATOM 11419 CA LEU B 188 69.721 36.993 −33.200 1.00 18.16 B C ATOM 11421 CB LEU B 188 70.409 37.449 −34.492 1.00 17.88 B C ATOM 11424 CG LEU B 188 70.820 38.925 −34.496 1.00 17.28 B C ATOM 11426 CD1 LEU B 188 71.831 39.217 −35.593 1.00 16.54 B C ATOM 11430 CD2 LEU B 188 69.600 39.820 −34.640 1.00 15.64 B C ATOM 11434 C LEU B 188 68.916 35.711 −33.436 1.00 17.88 B C ATOM 11435 O LEU B 188 67.764 35.775 −33.863 1.00 18.07 B O ATOM 11437 N GLU B 189 69.518 34.554 −33.164 1.00 17.45 B N ATOM 11438 CA GLU B 189 68.783 33.286 −33.161 1.00 17.00 B C ATOM 11440 CB GLU B 189 69.717 32.116 −32.830 1.00 16.79 B C ATOM 11443 CG GLU B 189 69.039 30.745 −32.807 1.00 16.46 B C ATOM 11446 CD GLU B 189 70.001 29.608 −32.506 1.00 16.49 B C ATOM 11447 OE1 GLU B 189 70.952 29.810 −31.720 1.00 17.45 B O ATOM 11448 OE2 GLU B 189 69.802 28.502 −33.051 1.00 16.29 B O ATOM 11449 C GLU B 189 67.647 33.354 −32.141 1.00 16.85 B C ATOM 11450 O GLU B 189 66.513 32.963 −32.430 1.00 16.54 B O ATOM 11452 N LEU B 190 67.973 33.852 −30.949 1.00 16.84 B N ATOM 11453 CA LEU B 190 67.008 34.033 −29.864 1.00 16.87 B C ATOM 11455 CB LEU B 190 66.646 32.680 −29.242 1.00 16.90 B C ATOM 11458 CG LEU B 190 65.420 32.614 −28.326 1.00 16.89 B C ATOM 11460 CD1 LEU B 190 64.144 32.781 −29.127 1.00 16.28 B C ATOM 11464 CD2 LEU B 190 65.395 31.296 −27.566 1.00 17.45 B C ATOM 11468 C LEU B 190 67.637 34.940 −28.801 1.00 16.77 B C ATOM 11469 O LEU B 190 68.826 34.803 −28.509 1.00 17.14 B O ATOM 11471 N PRO B 191 66.857 35.873 −28.222 1.00 16.38 B N ATOM 11472 CA PRO B 191 67.420 36.724 −27.166 1.00 16.04 B C ATOM 11474 CB PRO B 191 66.391 37.848 −27.040 1.00 15.95 B C ATOM 11477 CG PRO B 191 65.114 37.221 −27.453 1.00 16.28 B C ATOM 11480 CD PRO B 191 65.460 36.231 −28.527 1.00 16.22 B C ATOM 11483 C PRO B 191 67.576 35.981 −25.838 1.00 15.62 B C ATOM 11484 O PRO B 191 67.046 34.884 −25.682 1.00 15.70 B O ATOM 11485 N LEU B 192 68.303 36.578 −24.896 1.00 15.37 B N ATOM 11486 CA LEU B 192 68.515 35.973 −23.578 1.00 14.71 B C ATOM 11488 CB LEU B 192 69.477 36.810 −22.735 1.00 14.48 B C ATOM 11491 CG LEU B 192 70.931 36.828 −23.194 1.00 14.76 B C ATOM 11493 CD1 LEU B 192 71.650 38.005 −22.575 1.00 16.74 B C ATOM 11497 CD2 LEU B 192 71.627 35.526 −22.840 1.00 14.51 B C ATOM 11501 C LEU B 192 67.203 35.839 −22.833 1.00 14.18 B C ATOM 11502 O LEU B 192 66.930 34.801 −22.234 1.00 14.39 B O ATOM 11504 N HIS B 193 66.388 36.889 −22.891 1.00 13.57 B N ATOM 11505 CA HIS B 193 65.119 36.926 −22.170 1.00 13.63 B C ATOM 11507 CB HIS B 193 64.446 38.292 −22.363 1.00 13.58 B C ATOM 11510 CG HIS B 193 63.202 38.477 −21.548 1.00 13.03 B C ATOM 11511 ND1 HIS B 193 63.208 38.485 −20.170 1.00 13.37 B N ATOM 11513 CE1 HIS B 193 61.976 38.662 −19.727 1.00 13.22 B C ATOM 11515 NE2 HIS B 193 61.171 38.773 −20.769 1.00 11.40 B N ATOM 11517 CD2 HIS B 193 61.913 38.661 −21.920 1.00 11.23 B C ATOM 11519 C HIS B 193 64.160 35.795 −22.570 1.00 13.78 B C ATOM 11520 O HIS B 193 63.257 35.440 −21.802 1.00 13.38 B O ATOM 11522 N ARG B 194 64.365 35.224 −23.756 1.00 14.17 B N ATOM 11523 CA ARG B 194 63.487 34.175 −24.273 1.00 14.88 B C ATOM 11525 CB ARG B 194 62.992 34.567 −25.663 1.00 15.05 B C ATOM 11528 CG ARG B 194 62.208 35.872 −25.689 1.00 16.31 B C ATOM 11531 CD ARG B 194 61.684 36.153 −27.083 1.00 18.23 B C ATOM 11534 NE ARG B 194 60.754 37.277 −27.116 1.00 18.82 B N ATOM 11536 CZ ARG B 194 60.060 37.648 −28.190 1.00 18.69 B C ATOM 11537 NH1 ARG B 194 60.186 36.987 −29.338 1.00 19.08 B N ATOM 11540 NH2 ARG B 194 59.235 38.687 −28.117 1.00 19.19 B N ATOM 11543 C ARG B 194 64.126 32.785 −24.336 1.00 14.83 B C ATOM 11544 O ARG B 194 63.439 31.814 −24.648 1.00 15.42 B O ATOM 11546 N ARG B 195 65.421 32.681 −24.042 1.00 14.50 B N ATOM 11547 CA ARG B 195 66.118 31.398 −24.116 1.00 14.49 B C ATOM 11549 CB ARG B 195 67.545 31.588 −24.627 1.00 14.69 B C ATOM 11552 CG ARG B 195 68.145 30.336 −25.240 1.00 15.98 B C ATOM 11555 CD ARG B 195 69.649 30.461 −25.417 1.00 17.88 B C ATOM 11558 NE ARG B 195 70.028 31.579 −26.279 1.00 18.66 B N ATOM 11560 CZ ARG B 195 69.963 31.572 −27.610 1.00 20.86 B C ATOM 11561 NH1 ARG B 195 69.522 30.505 −28.274 1.00 21.51 B N ATOM 11564 NH2 ARG B 195 70.344 32.646 −28.289 1.00 22.00 B N ATOM 11567 C ARG B 195 66.141 30.733 −22.747 1.00 14.49 B C ATOM 11568 O ARG B 195 66.247 31.412 −21.723 1.00 14.49 B O ATOM 11570 N THR B 196 66.047 29.404 −22.736 1.00 14.52 B N ATOM 11571 CA THR B 196 66.036 28.641 −21.490 1.00 14.61 B C ATOM 11573 CB THR B 196 65.535 27.199 −21.701 1.00 14.72 B C ATOM 11575 OG1 THR B 196 66.358 26.536 −22.668 1.00 14.27 B O ATOM 11577 CG2 THR B 196 64.090 27.198 −22.178 1.00 15.09 B C ATOM 11581 C THR B 196 67.427 28.599 −20.868 1.00 14.74 B C ATOM 11582 O THR B 196 68.431 28.613 −21.577 1.00 14.94 B O ATOM 11584 N GLN B 197 67.464 28.529 −19.540 1.00 14.94 B N ATOM 11585 CA GLN B 197 68.707 28.631 −18.768 1.00 14.89 B C ATOM 11587 CB GLN B 197 68.415 28.398 −17.273 1.00 14.86 B C ATOM 11590 CG GLN B 197 69.335 29.146 −16.312 1.00 13.67 B C ATOM 11593 CD GLN B 197 70.536 28.336 −15.866 1.00 11.84 B C ATOM 11594 OE1 GLN B 197 71.150 27.618 −16.653 1.00 11.73 B O ATOM 11595 NE2 GLN B 197 70.885 28.460 −14.596 1.00 10.93 B N ATOM 11598 C GLN B 197 69.785 27.656 −19.250 1.00 15.04 B C ATOM 11599 O GLN B 197 70.916 28.058 −19.533 1.00 14.84 B O ATOM 11601 N ARG B 198 69.421 26.380 −19.353 1.00 15.25 B N ATOM 11602 CA ARG B 198 70.382 25.316 −19.657 1.00 15.00 B C ATOM 11604 CB ARG B 198 69.755 23.946 −19.396 1.00 14.97 B C ATOM 11607 CG ARG B 198 69.439 23.673 −17.932 1.00 15.36 B C ATOM 11610 CD ARG B 198 70.675 23.289 −17.132 1.00 15.24 B C ATOM 11613 NE ARG B 198 71.376 24.438 −16.564 1.00 15.04 B N ATOM 11615 CZ ARG B 198 72.401 24.347 −15.717 1.00 15.93 B C ATOM 11616 NH1 ARG B 198 72.855 23.160 −15.334 1.00 16.51 B N ATOM 11619 NH2 ARG B 198 72.977 25.447 −15.248 1.00 16.24 B N ATOM 11622 C ARG B 198 70.916 25.373 −21.086 1.00 14.67 B C ATOM 11623 O ARG B 198 72.093 25.083 −21.320 1.00 14.37 B O ATOM 11625 N LEU B 199 70.055 25.726 −22.038 1.00 14.51 B N ATOM 11626 CA LEU B 199 70.490 25.910 −23.427 1.00 14.52 B C ATOM 11628 CB LEU B 199 69.297 26.133 −24.378 1.00 14.65 B C ATOM 11631 CG LEU B 199 68.606 24.925 −25.037 1.00 14.01 B C ATOM 11633 CD1 LEU B 199 67.687 24.176 −24.064 1.00 13.56 B C ATOM 11637 CD2 LEU B 199 69.625 23.978 −25.659 1.00 12.13 B C ATOM 11641 C LEU B 199 71.458 27.091 −23.512 1.00 14.39 B C ATOM 11642 O LEU B 199 72.476 27.022 −24.207 1.00 14.42 B O ATOM 11644 N GLU B 200 71.132 28.168 −22.800 1.00 13.72 B N ATOM 11645 CA GLU B 200 71.998 29.335 −22.737 1.00 13.37 B C ATOM 11647 CB GLU B 200 71.312 30.473 −21.969 1.00 13.42 B C ATOM 11650 CG GLU B 200 72.160 31.723 −21.776 1.00 13.45 B C ATOM 11653 CD GLU B 200 72.875 32.157 −23.042 1.00 14.44 B C ATOM 11654 OE1 GLU B 200 72.268 32.095 −24.133 1.00 14.98 B O ATOM 11655 OE2 GLU B 200 74.049 32.561 −22.945 1.00 15.44 B O ATOM 11656 C GLU B 200 73.317 28.968 −22.071 1.00 13.44 B C ATOM 11657 O GLU B 200 74.389 29.324 −22.561 1.00 13.42 B O ATOM 11659 N ALA B 201 73.229 28.248 −20.959 1.00 13.64 B N ATOM 11660 CA ALA B 201 74.414 27.828 −20.222 1.00 14.07 B C ATOM 11662 CB ALA B 201 74.017 27.028 −18.991 1.00 14.39 B C ATOM 11666 C ALA B 201 75.371 27.018 −21.094 1.00 14.43 B C ATOM 11667 O ALA B 201 76.564 27.319 −21.144 1.00 14.77 B O ATOM 11669 N VAL B 202 74.849 26.008 −21.791 1.00 14.63 B N ATOM 11670 CA VAL B 202 75.691 25.119 −22.602 1.00 14.73 B C ATOM 11672 CB VAL B 202 74.885 23.939 −23.206 1.00 14.72 B C ATOM 11674 CG1 VAL B 202 73.980 24.415 −24.333 1.00 15.60 B C ATOM 11678 CG2 VAL B 202 75.828 22.852 −23.706 1.00 13.72 B C ATOM 11682 C VAL B 202 76.425 25.865 −23.723 1.00 14.67 B C ATOM 11683 O VAL B 202 77.535 25.484 −24.101 1.00 14.54 B O ATOM 11685 N TRP B 203 75.809 26.926 −24.238 1.00 14.66 B N ATOM 11686 CA TRP B 203 76.417 27.728 −25.295 1.00 14.84 B C ATOM 11688 CB TRP B 203 75.344 28.484 −26.083 1.00 14.97 B C ATOM 11691 CG TRP B 203 75.916 29.258 −27.217 1.00 14.08 B C ATOM 11692 CD1 TRP B 203 76.114 28.818 −28.491 1.00 13.97 B C ATOM 11694 NE1 TRP B 203 76.677 29.812 −29.251 1.00 14.19 B N ATOM 11696 CE2 TRP B 203 76.860 30.919 −28.465 1.00 13.10 B C ATOM 11697 CD2 TRP B 203 76.393 30.603 −27.176 1.00 12.77 B C ATOM 11698 CE3 TRP B 203 76.465 31.575 −26.173 1.00 13.68 B C ATOM 11700 CZ3 TRP B 203 76.993 32.812 −26.486 1.00 14.21 B C ATOM 11702 CH2 TRP B 203 77.449 33.096 −27.778 1.00 14.39 B C ATOM 11704 CZ2 TRP B 203 77.393 32.165 −28.779 1.00 13.69 B C ATOM 11706 C TRP B 203 77.438 28.722 −24.739 1.00 15.07 B C ATOM 11707 O TRP B 203 78.578 28.779 −25.211 1.00 15.56 B O ATOM 11709 N SER B 204 77.018 29.507 −23.749 1.00 14.73 B N ATOM 11710 CA SER B 204 77.861 30.563 −23.179 1.00 14.32 B C ATOM 11712 CB SER B 204 77.084 31.382 −22.146 1.00 14.36 B C ATOM 11715 OG SER B 204 76.240 32.322 −22.781 1.00 13.68 B O ATOM 11717 C SER B 204 79.149 30.044 −22.549 1.00 14.07 B C ATOM 11718 O SER B 204 80.164 30.735 −22.583 1.00 14.22 B O ATOM 11720 N ILE B 205 79.103 28.840 −21.976 1.00 13.65 B N ATOM 11721 CA ILE B 205 80.286 28.223 −21.365 1.00 13.54 B C ATOM 11723 CB ILE B 205 79.918 26.963 −20.542 1.00 13.39 B C ATOM 11725 CG1 ILE B 205 79.225 27.367 −19.241 1.00 13.19 B C ATOM 11728 CD1 ILE B 205 78.813 26.197 −18.372 1.00 13.69 B C ATOM 11732 CG2 ILE B 205 81.162 26.151 −20.208 1.00 13.60 B C ATOM 11736 C ILE B 205 81.352 27.870 −22.410 1.00 13.51 B C ATOM 11737 O ILE B 205 82.542 28.105 −22.193 1.00 12.96 B O ATOM 11739 N GLU B 206 80.918 27.309 −23.536 1.00 13.71 B N ATOM 11740 CA GLU B 206 81.822 26.989 −24.640 1.00 13.71 B C ATOM 11742 CB GLU B 206 81.084 26.164 −25.706 1.00 13.88 B C ATOM 11745 CG GLU B 206 81.888 25.840 −26.973 1.00 15.04 B C ATOM 11748 CD GLU B 206 83.222 25.163 −26.693 1.00 15.38 B C ATOM 11749 OE1 GLU B 206 83.322 24.405 −25.704 1.00 15.76 B O ATOM 11750 OE2 GLU B 206 84.172 25.387 −27.474 1.00 15.99 B O ATOM 11751 C GLU B 206 82.418 28.263 −25.253 1.00 13.41 B C ATOM 11752 O GLU B 206 83.603 28.303 −25.581 1.00 12.99 B O ATOM 11754 N ALA B 207 81.592 29.297 −25.397 1.00 13.13 B N ATOM 11755 CA ALA B 207 82.037 30.583 −25.938 1.00 12.74 B C ATOM 11757 CB ALA B 207 80.834 31.472 −26.228 1.00 12.73 B C ATOM 11761 C ALA B 207 83.008 31.300 −24.997 1.00 12.41 B C ATOM 11762 O ALA B 207 84.012 31.856 −25.441 1.00 11.95 B O ATOM 11764 N TYR B 208 82.695 31.283 −23.702 1.00 12.40 B N ATOM 11765 CA TYR B 208 83.506 31.947 −22.674 1.00 12.38 B C ATOM 11767 CB TYR B 208 82.719 32.017 −21.359 1.00 12.14 B C ATOM 11770 CG TYR B 208 83.307 32.930 −20.307 1.00 11.69 B C ATOM 11771 CD1 TYR B 208 83.112 34.307 −20.366 1.00 12.57 B C ATOM 11773 CE1 TYR B 208 83.640 35.152 −19.398 1.00 13.17 B C ATOM 11775 CZ TYR B 208 84.367 34.620 −18.349 1.00 13.50 B C ATOM 11776 OH TYR B 208 84.891 35.454 −17.388 1.00 14.79 B O ATOM 11778 CE2 TYR B 208 84.568 33.254 −18.262 1.00 12.55 B C ATOM 11780 CD2 TYR B 208 84.035 32.417 −19.238 1.00 11.68 B C ATOM 11782 C TYR B 208 84.834 31.221 −22.450 1.00 12.66 B C ATOM 11783 O TYR B 208 85.840 31.841 −22.109 1.00 12.19 B O ATOM 11785 N ARG B 209 84.818 29.904 −22.637 1.00 13.27 B N ATOM 11786 CA ARG B 209 86.020 29.073 −22.563 1.00 13.72 B C ATOM 11788 CB ARG B 209 85.627 27.607 −22.794 1.00 13.38 B C ATOM 11791 CG ARG B 209 86.776 26.618 −22.939 1.00 13.64 B C ATOM 11794 CD ARG B 209 86.308 25.339 −23.618 1.00 12.76 B C ATOM 11797 NE ARG B 209 85.380 24.576 −22.789 1.00 8.75 B N ATOM 11799 CZ ARG B 209 85.737 23.800 −21.769 1.00 7.83 B C ATOM 11800 NH1 ARG B 209 87.014 23.671 −21.418 1.00 7.53 B N ATOM 11803 NH2 ARG B 209 84.805 23.149 −21.088 1.00 9.72 B N ATOM 11806 C ARG B 209 87.091 29.520 −23.574 1.00 14.74 B C ATOM 11807 O ARG B 209 88.291 29.385 −23.317 1.00 14.87 B O ATOM 11809 N LYS B 210 86.653 30.052 −24.715 1.00 15.63 B N ATOM 11810 CA LYS B 210 87.566 30.517 −25.763 1.00 16.08 B C ATOM 11812 CB LYS B 210 86.837 30.620 −27.106 1.00 16.07 B C ATOM 11815 CG LYS B 210 86.325 29.290 −27.644 1.00 16.25 B C ATOM 11818 CD LYS B 210 85.403 29.498 −28.838 1.00 15.92 B C ATOM 11821 CE LYS B 210 84.773 28.196 −29.298 1.00 15.10 B C ATOM 11824 NZ LYS B 210 83.951 28.393 −30.523 1.00 14.52 B N ATOM 11828 C LYS B 210 88.218 31.861 −25.437 1.00 16.75 B C ATOM 11829 O LYS B 210 89.311 32.145 −25.928 1.00 17.30 B O ATOM 11831 N LYS B 211 87.555 32.687 −24.627 1.00 17.35 B N ATOM 11832 CA LYS B 211 88.104 33.994 −24.247 1.00 17.95 B C ATOM 11834 CB LYS B 211 87.083 34.814 −23.445 1.00 18.18 B C ATOM 11837 CG LYS B 211 85.851 35.242 −24.233 1.00 18.73 B C ATOM 11840 CD LYS B 211 85.015 36.254 −23.458 1.00 19.41 B C ATOM 11843 CE LYS B 211 83.593 36.355 −24.010 1.00 20.51 B C ATOM 11846 NZ LYS B 211 83.552 36.703 −25.461 1.00 20.75 B N ATOM 11850 C LYS B 211 89.388 33.830 −23.431 1.00 18.28 B C ATOM 11851 O LYS B 211 89.364 33.281 −22.329 1.00 18.16 B O ATOM 11853 N GLU B 212 90.503 34.311 −23.978 1.00 18.88 B N ATOM 11854 CA GLU B 212 91.801 34.227 −23.300 1.00 19.31 B C ATOM 11856 CB GLU B 212 92.933 34.639 −24.248 1.00 19.39 B C ATOM 11859 CG GLU B 212 94.323 34.194 −23.793 1.00 19.97 B C ATOM 11862 CD GLU B 212 95.445 34.816 −24.608 1.00 20.72 B C ATOM 11863 OE1 GLU B 212 95.377 36.028 −24.905 1.00 21.30 B O ATOM 11864 OE2 GLU B 212 96.407 34.093 −24.941 1.00 20.66 B O ATOM 11865 C GLU B 212 91.831 35.098 −22.040 1.00 19.46 B C ATOM 11866 O GLU B 212 92.651 34.880 −21.146 1.00 19.79 B O ATOM 11868 N ASP B 213 90.932 36.078 −21.979 1.00 19.22 B N ATOM 11869 CA ASP B 213 90.816 36.973 −20.830 1.00 19.09 B C ATOM 11871 CB ASP B 213 90.503 38.398 −21.309 1.00 19.27 B C ATOM 11874 CG ASP B 213 89.263 38.464 −22.186 1.00 19.40 B C ATOM 11875 OD1 ASP B 213 89.198 37.713 −23.183 1.00 19.36 B O ATOM 11876 OD2 ASP B 213 88.360 39.271 −21.884 1.00 21.12 B O ATOM 11877 C ASP B 213 89.750 36.516 −19.828 1.00 18.88 B C ATOM 11878 O ASP B 213 89.341 37.294 −18.966 1.00 19.17 B O ATOM 11880 N ALA B 214 89.316 35.260 −19.926 1.00 18.57 B N ATOM 11881 CA ALA B 214 88.229 34.750 −19.084 1.00 18.24 B C ATOM 11883 CB ALA B 214 87.574 33.549 −19.740 1.00 18.18 B C ATOM 11887 C ALA B 214 88.712 34.383 −17.683 1.00 18.02 B C ATOM 11888 O ALA B 214 89.828 33.891 −17.511 1.00 17.90 B O ATOM 11890 N ASN B 215 87.857 34.627 −16.690 1.00 17.91 B N ATOM 11891 CA ASN B 215 88.151 34.300 −15.297 1.00 17.91 B C ATOM 11893 CB ASN B 215 87.225 35.079 −14.355 1.00 17.98 B C ATOM 11896 CG ASN B 215 87.530 34.835 −12.882 1.00 18.96 B C ATOM 11897 OD1 ASN B 215 88.546 34.235 −12.531 1.00 20.95 B O ATOM 11898 ND2 ASN B 215 86.646 35.311 −12.012 1.00 20.55 B N ATOM 11901 C ASN B 215 87.989 32.801 −15.079 1.00 17.88 B C ATOM 11902 O ASN B 215 86.871 32.288 −15.067 1.00 18.40 B O ATOM 11904 N GLN B 216 89.110 32.109 −14.897 1.00 17.67 B N ATOM 11905 CA GLN B 216 89.123 30.648 −14.814 1.00 17.28 B C ATOM 11907 CB GLN B 216 90.559 30.125 −14.732 1.00 17.40 B C ATOM 11910 CG GLN B 216 91.454 30.489 −15.919 1.00 18.55 B C ATOM 11913 CD GLN B 216 91.101 29.741 −17.193 1.00 19.04 B C ATOM 11914 OE1 GLN B 216 90.043 29.961 −17.788 1.00 19.21 B O ATOM 11915 NE2 GLN B 216 91.999 28.863 −17.628 1.00 20.05 B N ATOM 11918 C GLN B 216 88.334 30.149 −13.610 1.00 16.63 B C ATOM 11919 O GLN B 216 87.517 29.234 −13.733 1.00 16.72 B O ATOM 11921 N VAL B 217 88.583 30.759 −12.453 1.00 15.82 B N ATOM 11922 CA VAL B 217 87.865 30.422 −11.224 1.00 15.08 B C ATOM 11924 CB VAL B 217 88.187 31.414 −10.079 1.00 15.07 B C ATOM 11926 CG1 VAL B 217 87.308 31.142 −8.868 1.00 14.72 B C ATOM 11930 CG2 VAL B 217 89.660 31.324 −9.694 1.00 15.15 B C ATOM 11934 C VAL B 217 86.360 30.394 −11.481 1.00 14.47 B C ATOM 11935 O VAL B 217 85.678 29.458 −11.067 1.00 14.91 B O ATOM 11937 N LEU B 218 85.852 31.405 −12.180 1.00 13.50 B N ATOM 11938 CA LEU B 218 84.441 31.437 −12.553 1.00 12.95 B C ATOM 11940 CB LEU B 218 84.069 32.789 −13.179 1.00 12.79 B C ATOM 11943 CG LEU B 218 82.617 32.980 −13.641 1.00 11.49 B C ATOM 11945 CD1 LEU B 218 81.627 32.691 −12.524 1.00 8.68 B C ATOM 11949 CD2 LEU B 218 82.416 34.384 −14.174 1.00 10.75 B C ATOM 11953 C LEU B 218 84.110 30.301 −13.517 1.00 12.90 B C ATOM 11954 O LEU B 218 83.134 29.579 −13.311 1.00 13.48 B O ATOM 11956 N LEU B 219 84.930 30.144 −14.555 1.00 12.44 B N ATOM 11957 CA LEU B 219 84.683 29.154 −15.609 1.00 12.25 B C ATOM 11959 CB LEU B 219 85.739 29.272 −16.715 1.00 12.47 B C ATOM 11962 CG LEU B 219 85.676 28.253 −17.864 1.00 13.40 B C ATOM 11964 CD1 LEU B 219 84.303 28.247 −18.520 1.00 12.39 B C ATOM 11968 CD2 LEU B 219 86.761 28.534 −18.896 1.00 13.97 B C ATOM 11972 C LEU B 219 84.649 27.720 −15.079 1.00 11.89 B C ATOM 11973 O LEU B 219 83.772 26.938 −15.451 1.00 12.23 B O ATOM 11975 N GLU B 220 85.607 27.379 −14.222 1.00 11.04 B N ATOM 11976 CA GLU B 220 85.691 26.034 −13.648 1.00 10.39 B C ATOM 11978 CB GLU B 220 86.885 25.938 −12.694 1.00 10.57 B C ATOM 11981 CG GLU B 220 87.164 24.540 −12.157 1.00 10.41 B C ATOM 11984 CD GLU B 220 88.415 24.484 −11.300 1.00 11.88 B C ATOM 11985 OE1 GLU B 220 89.036 25.544 −11.076 1.00 13.40 B O ATOM 11986 OE2 GLU B 220 88.779 23.380 −10.846 1.00 13.69 B O ATOM 11987 C GLU B 220 84.401 25.682 −12.913 1.00 9.41 B C ATOM 11988 O GLU B 220 83.838 24.607 −13.110 1.00 9.34 B O ATOM 11990 N LEU B 221 83.944 26.604 −12.072 1.00 8.59 B N ATOM 11991 CA LEU B 221 82.689 26.452 −11.338 1.00 7.91 B C ATOM 11993 CB LEU B 221 82.470 27.675 −10.445 1.00 7.25 B C ATOM 11996 CG LEU B 221 81.299 27.637 −9.470 1.00 5.48 B C ATOM 11998 CD1 LEU B 221 81.473 26.510 −8.472 1.00 2.94 B C ATOM 12002 CD2 LEU B 221 81.180 28.974 −8.765 1.00 3.79 B C ATOM 12006 C LEU B 221 81.507 26.285 −12.298 1.00 8.00 B C ATOM 12007 O LEU B 221 80.662 25.402 −12.116 1.00 7.50 B O ATOM 12009 N ALA B 222 81.464 27.141 −13.316 1.00 7.90 B N ATOM 12010 CA ALA B 222 80.434 27.087 −14.348 1.00 8.12 B C ATOM 12012 CB ALA B 222 80.752 28.080 −15.451 1.00 8.09 B C ATOM 12016 C ALA B 222 80.287 25.684 −14.933 1.00 8.56 B C ATOM 12017 O ALA B 222 79.171 25.191 −15.104 1.00 8.85 B O ATOM 12019 N ILE B 223 81.418 25.048 −15.230 1.00 8.90 B N ATOM 12020 CA ILE B 223 81.428 23.699 −15.793 1.00 9.10 B C ATOM 12022 CB ILE B 223 82.812 23.336 −16.366 1.00 9.15 B C ATOM 12024 CG1 ILE B 223 83.153 24.241 −17.550 1.00 9.69 B C ATOM 12027 CD1 ILE B 223 84.570 24.078 −18.041 1.00 11.92 B C ATOM 12031 CG2 ILE B 223 82.845 21.881 −16.816 1.00 8.99 B C ATOM 12035 C ILE B 223 81.030 22.657 −14.750 1.00 9.24 B C ATOM 12036 O ILE B 223 80.215 21.777 −15.028 1.00 9.09 B O ATOM 12038 N LEU B 224 81.612 22.756 −13.557 1.00 9.68 B N ATOM 12039 CA LEU B 224 81.306 21.822 −12.468 1.00 10.03 B C ATOM 12041 CB LEU B 224 82.114 22.156 −11.208 1.00 9.46 B C ATOM 12044 CG LEU B 224 83.367 21.311 −10.988 1.00 9.22 B C ATOM 12046 CD1 LEU B 224 84.199 21.177 −12.262 1.00 8.16 B C ATOM 12050 CD2 LEU B 224 84.193 21.895 −9.856 1.00 10.80 B C ATOM 12054 C LEU B 224 79.821 21.809 −12.130 1.00 10.73 B C ATOM 12055 O LEU B 224 79.209 20.742 −12.032 1.00 10.93 B O ATOM 12057 N ASP B 225 79.252 22.999 −11.959 1.00 11.11 B N ATOM 12058 CA ASP B 225 77.860 23.124 −11.556 1.00 11.25 B C ATOM 12060 CB ASP B 225 77.505 24.585 −11.282 1.00 11.10 B C ATOM 12063 CG ASP B 225 76.227 24.727 −10.487 1.00 11.83 B C ATOM 12064 OD1 ASP B 225 75.198 25.135 −11.071 1.00 10.54 B O ATOM 12065 OD2 ASP B 225 76.248 24.405 −9.280 1.00 11.82 B O ATOM 12066 C ASP B 225 76.939 22.549 −12.627 1.00 11.77 B C ATOM 12067 O ASP B 225 76.014 21.798 −12.316 1.00 11.63 B O ATOM 12069 N TYR B 226 77.209 22.891 −13.885 1.00 12.20 B N ATOM 12070 CA TYR B 226 76.415 22.393 −15.005 1.00 12.70 B C ATOM 12072 CB TYR B 226 76.962 22.925 −16.332 1.00 12.61 B C ATOM 12075 CG TYR B 226 76.133 22.538 −17.541 1.00 12.38 B C ATOM 12076 CD1 TYR B 226 75.212 23.421 −18.090 1.00 12.61 B C ATOM 12078 CE1 TYR B 226 74.455 23.069 −19.199 1.00 13.81 B C ATOM 12080 CZ TYR B 226 74.615 21.818 −19.768 1.00 13.32 B C ATOM 12081 OH TYR B 226 73.869 21.457 −20.866 1.00 14.04 B O ATOM 12083 CE2 TYR B 226 75.522 20.926 −19.239 1.00 11.80 B C ATOM 12085 CD2 TYR B 226 76.274 21.287 −18.135 1.00 11.70 B C ATOM 12087 C TYR B 226 76.365 20.861 −15.025 1.00 13.36 B C ATOM 12088 O TYR B 226 75.290 20.273 −15.170 1.00 14.07 B O ATOM 12090 N ASN B 227 77.527 20.225 −14.882 1.00 13.50 B N ATOM 12091 CA ASN B 227 77.611 18.764 −14.862 1.00 13.63 B C ATOM 12093 CB ASN B 227 79.074 18.302 −14.837 1.00 13.86 B C ATOM 12096 CG ASN B 227 79.789 18.524 −16.161 1.00 14.25 B C ATOM 12097 OD1 ASN B 227 79.172 18.516 −17.230 1.00 13.18 B O ATOM 12098 ND2 ASN B 227 81.104 18.712 −16.094 1.00 12.89 B N ATOM 12101 C ASN B 227 76.866 18.166 −13.673 1.00 13.81 B C ATOM 12102 O ASN B 227 76.139 17.186 −13.824 1.00 13.98 B O ATOM 12104 N MET B 228 77.053 18.757 −12.495 1.00 14.03 B N ATOM 12105 CA MET B 228 76.345 18.325 −11.288 1.00 14.59 B C ATOM 12107 CB MET B 228 76.698 19.234 −10.107 1.00 15.31 B C ATOM 12110 CG MET B 228 75.985 18.894 −8.792 1.00 16.38 B C ATOM 12113 SD MET B 228 75.944 20.288 −7.645 1.00 18.68 B S ATOM 12114 CE MET B 228 74.714 21.327 −8.435 1.00 17.56 B C ATOM 12118 C MET B 228 74.835 18.345 −11.507 1.00 14.50 B C ATOM 12119 O MET B 228 74.136 17.402 −11.138 1.00 14.64 B O ATOM 12121 N ILE B 229 74.337 19.427 −12.097 1.00 14.25 B N ATOM 12122 CA ILE B 229 72.916 19.538 −12.398 1.00 14.20 B C ATOM 12124 CB ILE B 229 72.537 20.957 −12.857 1.00 14.37 B C ATOM 12126 CG1 ILE B 229 72.802 21.973 −11.741 1.00 14.47 B C ATOM 12129 CD1 ILE B 229 72.024 23.268 −11.891 1.00 13.51 B C ATOM 12133 CG2 ILE B 229 71.074 21.011 −13.262 1.00 15.42 B C ATOM 12137 C ILE B 229 72.528 18.523 −13.470 1.00 13.75 B C ATOM 12138 O ILE B 229 71.558 17.789 −13.310 1.00 13.08 B O ATOM 12140 N GLN B 230 73.297 18.476 −14.554 1.00 14.01 B N ATOM 12141 CA GLN B 230 73.092 17.472 −15.599 1.00 14.55 B C ATOM 12143 CB GLN B 230 74.216 17.535 −16.640 1.00 14.49 B C ATOM 12146 CG GLN B 230 74.086 16.503 −17.757 1.00 13.89 B C ATOM 12149 CD GLN B 230 75.223 16.564 −18.755 1.00 12.94 B C ATOM 12150 OE1 GLN B 230 76.100 15.701 −18.761 1.00 12.13 B O ATOM 12151 NE2 GLN B 230 75.213 17.582 −19.608 1.00 10.57 B N ATOM 12154 C GLN B 230 72.996 16.052 −15.026 1.00 15.29 B C ATOM 12155 O GLN B 230 72.177 15.255 −15.481 1.00 15.71 B O ATOM 12157 N SER B 231 73.832 15.739 −14.037 1.00 15.66 B N ATOM 12158 CA SER B 231 73.793 14.425 −13.387 1.00 15.81 B C ATOM 12160 CB SER B 231 75.004 14.227 −12.468 1.00 15.73 B C ATOM 12163 OG SER B 231 74.848 14.926 −11.246 1.00 16.09 B O ATOM 12165 C SER B 231 72.492 14.223 −12.600 1.00 16.06 B C ATOM 12166 O SER B 231 71.989 13.102 −12.511 1.00 15.88 B O ATOM 12168 N VAL B 232 71.959 15.306 −12.034 1.00 16.47 B N ATOM 12169 CA VAL B 232 70.661 15.266 −11.355 1.00 16.95 B C ATOM 12171 CB VAL B 232 70.343 16.593 −10.607 1.00 17.13 B C ATOM 12173 CG1 VAL B 232 68.971 16.529 −9.941 1.00 16.99 B C ATOM 12177 CG2 VAL B 232 71.412 16.892 −9.570 1.00 18.25 B C ATOM 12181 C VAL B 232 69.543 14.957 −12.355 1.00 17.08 B C ATOM 12182 O VAL B 232 68.608 14.229 −12.032 1.00 17.31 B O ATOM 12184 N TYR B 233 69.646 15.502 −13.566 1.00 17.20 B N ATOM 12185 CA TYR B 233 68.679 15.203 −14.624 1.00 17.30 B C ATOM 12187 CB TYR B 233 68.880 16.109 −15.842 1.00 17.15 B C ATOM 12190 CG TYR B 233 68.763 17.600 −15.593 1.00 16.58 B C ATOM 12191 CD1 TYR B 233 68.056 18.113 −14.502 1.00 14.97 B C ATOM 12193 CE1 TYR B 233 67.957 19.481 −14.296 1.00 14.04 B C ATOM 12195 CZ TYR B 233 68.549 20.349 −15.194 1.00 14.25 B C ATOM 12196 OH TYR B 233 68.461 21.706 −15.012 1.00 13.90 B O ATOM 12198 CE2 TYR B 233 69.240 19.866 −16.283 1.00 15.45 B C ATOM 12200 CD2 TYR B 233 69.341 18.503 −16.479 1.00 16.33 B C ATOM 12202 C TYR B 233 68.782 13.750 −15.077 1.00 17.89 B C ATOM 12203 O TYR B 233 67.772 13.135 −15.421 1.00 18.00 B O ATOM 12205 N GLN B 234 70.003 13.215 −15.093 1.00 18.54 B N ATOM 12206 CA GLN B 234 70.234 11.817 −15.465 1.00 18.95 B C ATOM 12208 CB GLN B 234 71.730 11.535 −15.644 1.00 18.86 B C ATOM 12211 CG GLN B 234 72.324 12.116 −16.920 1.00 18.09 B C ATOM 12214 CD GLN B 234 73.816 11.854 −17.051 1.00 17.24 B C ATOM 12215 OE1 GLN B 234 74.324 10.830 −16.593 1.00 17.14 B O ATOM 12216 NE2 GLN B 234 74.524 12.779 −17.686 1.00 15.08 B N ATOM 12219 C GLN B 234 69.638 10.858 −14.434 1.00 19.60 B C ATOM 12220 O GLN B 234 69.011 9.865 −14.802 1.00 19.31 B O ATOM 12222 N ARG B 235 69.837 11.156 −13.151 1.00 20.61 B N ATOM 12223 CA ARG B 235 69.232 10.365 −12.074 1.00 21.86 B C ATOM 12225 CB ARG B 235 69.842 10.722 −10.712 1.00 22.48 B C ATOM 12228 CG ARG B 235 69.357 9.837 −9.562 1.00 24.72 B C ATOM 12231 CD ARG B 235 70.130 10.088 −8.272 1.00 28.63 B C ATOM 12234 NE ARG B 235 70.043 11.485 −7.828 1.00 32.42 B N ATOM 12236 CZ ARG B 235 71.016 12.398 −7.918 1.00 33.76 B C ATOM 12237 NH1 ARG B 235 72.205 12.098 −8.440 1.00 34.56 B N ATOM 12240 NH2 ARG B 235 70.799 13.633 −7.472 1.00 33.57 B N ATOM 12243 C ARG B 235 67.710 10.550 −12.039 1.00 21.94 B C ATOM 12244 O ARG B 235 66.976 9.623 −11.687 1.00 22.34 B O ATOM 12246 N ASP B 236 67.244 11.745 −12.393 1.00 21.69 B N ATOM 12247 CA ASP B 236 65.818 11.975 −12.584 1.00 21.55 B C ATOM 12249 CB ASP B 236 65.530 13.445 −12.920 1.00 21.49 B C ATOM 12252 CG ASP B 236 65.742 14.384 −11.737 1.00 21.70 B C ATOM 12253 OD1 ASP B 236 65.961 13.915 −10.601 1.00 22.53 B O ATOM 12254 OD2 ASP B 236 65.694 15.611 −11.951 1.00 20.61 B O ATOM 12255 C ASP B 236 65.324 11.086 −13.719 1.00 21.53 B C ATOM 12256 O ASP B 236 64.440 10.255 −13.520 1.00 21.51 B O ATOM 12258 N LEU B 237 65.929 11.247 −14.895 1.00 21.85 B N ATOM 12259 CA LEU B 237 65.483 10.568 −16.117 1.00 22.44 B C ATOM 12261 CB LEU B 237 66.369 10.963 −17.307 1.00 22.59 B C ATOM 12264 CG LEU B 237 65.987 10.394 −18.683 1.00 22.86 B C ATOM 12266 CD1 LEU B 237 64.591 10.840 −19.099 1.00 22.39 B C ATOM 12270 CD2 LEU B 237 67.011 10.801 −19.734 1.00 23.22 B C ATOM 12274 C LEU B 237 65.435 9.043 −16.002 1.00 22.87 B C ATOM 12275 O LEU B 237 64.508 8.421 −16.518 1.00 23.17 B O ATOM 12277 N ARG B 238 66.429 8.445 −15.347 1.00 23.22 B N ATOM 12278 CA ARG B 238 66.465 6.986 −15.167 1.00 23.20 B C ATOM 12280 CB ARG B 238 67.747 6.544 −14.453 1.00 23.33 B C ATOM 12283 CG ARG B 238 68.977 6.488 −15.348 1.00 24.49 B C ATOM 12286 CD ARG B 238 70.111 5.717 −14.683 1.00 25.92 B C ATOM 12289 NE ARG B 238 70.498 6.303 −13.397 1.00 27.40 B N ATOM 12291 CZ ARG B 238 71.452 7.219 −13.216 1.00 27.20 B C ATOM 12292 NH1 ARG B 238 72.161 7.693 −14.239 1.00 26.98 B N ATOM 12295 NH2 ARG B 238 71.701 7.669 −11.991 1.00 27.09 B N ATOM 12298 C ARG B 238 65.253 6.480 −14.393 1.00 23.04 B C ATOM 12299 O ARG B 238 64.725 5.416 −14.697 1.00 22.74 B O ATOM 12301 N GLU B 239 64.822 7.252 −13.397 1.00 23.57 B N ATOM 12302 CA GLU B 239 63.645 6.916 −12.592 1.00 24.22 B C ATOM 12304 CB GLU B 239 63.617 7.774 −11.322 1.00 24.77 B C ATOM 12307 CG GLU B 239 62.618 7.317 −10.265 1.00 26.77 B C ATOM 12310 CD GLU B 239 62.813 8.028 −8.934 1.00 29.81 B C ATOM 12311 OE1 GLU B 239 63.910 7.911 −8.348 1.00 30.83 B O ATOM 12312 OE2 GLU B 239 61.867 8.702 −8.469 1.00 32.55 B O ATOM 12313 C GLU B 239 62.338 7.085 −13.382 1.00 23.78 B C ATOM 12314 O GLU B 239 61.406 6.293 −13.224 1.00 23.75 B O ATOM 12316 N THR B 240 62.271 8.115 −14.222 1.00 23.31 B N ATOM 12317 CA THR B 240 61.130 8.298 −15.122 1.00 23.25 B C ATOM 12319 CB THR B 240 61.132 9.703 −15.767 1.00 23.05 B C ATOM 12321 OG1 THR B 240 61.223 10.703 −14.746 1.00 22.86 B O ATOM 12323 CG2 THR B 240 59.862 9.932 −16.574 1.00 22.22 B C ATOM 12327 C THR B 240 61.135 7.236 −16.227 1.00 23.58 B C ATOM 12328 O THR B 240 60.076 6.746 −16.630 1.00 23.36 B O ATOM 12330 N SER B 241 62.330 6.888 −16.707 1.00 23.85 B N ATOM 12331 CA SER B 241 62.500 5.878 −17.758 1.00 24.00 B C ATOM 12333 CB SER B 241 63.943 5.868 −18.271 1.00 24.23 B C ATOM 12336 OG SER B 241 64.304 7.126 −18.813 1.00 25.12 B O ATOM 12338 C SER B 241 62.124 4.479 −17.280 1.00 24.04 B C ATOM 12339 O SER B 241 61.531 3.705 −18.032 1.00 23.92 B O ATOM 12341 N ARG B 242 62.483 4.151 −16.039 1.00 24.20 B N ATOM 12342 CA ARG B 242 62.037 2.900 −15.427 1.00 24.47 B C ATOM 12344 CB ARG B 242 62.565 2.741 −13.992 1.00 24.64 B C ATOM 12347 CG ARG B 242 63.977 2.149 −13.889 1.00 25.62 B C ATOM 12350 CD ARG B 242 64.220 1.493 −12.525 1.00 25.82 B C ATOM 12353 NE ARG B 242 63.800 2.347 −11.411 1.00 26.44 B N ATOM 12355 CZ ARG B 242 64.518 3.342 −10.885 1.00 26.48 B C ATOM 12356 NH1 ARG B 242 64.020 4.045 −9.874 1.00 25.75 B N ATOM 12359 NH2 ARG B 242 65.725 3.644 −11.356 1.00 27.75 B N ATOM 12362 C ARG B 242 60.512 2.851 −15.429 1.00 24.30 B C ATOM 12363 O ARG B 242 59.919 1.885 −15.909 1.00 24.90 B O ATOM 12365 N TRP B 243 59.887 3.903 −14.906 1.00 23.61 B N ATOM 12366 CA TRP B 243 58.429 4.000 −14.888 1.00 22.97 B C ATOM 12368 CB TRP B 243 57.982 5.318 −14.237 1.00 22.79 B C ATOM 12371 CG TRP B 243 56.531 5.655 −14.463 1.00 21.51 B C ATOM 12372 CD1 TRP B 243 55.465 5.256 −13.708 1.00 20.30 B C ATOM 12374 NE1 TRP B 243 54.301 5.768 −14.228 1.00 19.74 B N ATOM 12376 CE2 TRP B 243 54.599 6.513 −15.339 1.00 19.29 B C ATOM 12377 CD2 TRP B 243 55.995 6.466 −15.517 1.00 19.30 B C ATOM 12378 CE3 TRP B 243 56.561 7.151 −16.597 1.00 18.07 B C ATOM 12380 CZ3 TRP B 243 55.728 7.850 −17.453 1.00 17.55 B C ATOM 12382 CH2 TRP B 243 54.344 7.880 −17.252 1.00 17.66 B C ATOM 12384 CZ2 TRP B 243 53.759 7.218 −16.205 1.00 19.44 B C ATOM 12386 C TRP B 243 57.852 3.879 −16.299 1.00 22.95 B C ATOM 12387 O TRP B 243 56.882 3.151 −16.515 1.00 23.06 B O ATOM 12389 N TRP B 244 58.457 4.585 −17.252 1.00 22.77 B N ATOM 12390 CA TRP B 244 57.944 4.624 −18.624 1.00 22.56 B C ATOM 12392 CB TRP B 244 58.743 5.624 −19.473 1.00 22.41 B C ATOM 12395 CG TRP B 244 58.196 5.866 −20.872 1.00 21.79 B C ATOM 12396 CD1 TRP B 244 58.907 5.853 −22.041 1.00 21.43 B C ATOM 12398 NE1 TRP B 244 58.078 6.124 −23.105 1.00 20.15 B N ATOM 12400 CE2 TRP B 244 56.804 6.314 −22.641 1.00 18.38 B C ATOM 12401 CD2 TRP B 244 56.836 6.162 −21.238 1.00 19.68 B C ATOM 12402 CE3 TRP B 244 55.644 6.312 −20.517 1.00 17.93 B C ATOM 12404 CZ3 TRP B 244 54.482 6.602 −21.206 1.00 16.17 B C ATOM 12406 CH2 TRP B 244 54.483 6.745 −22.599 1.00 16.40 B C ATOM 12408 CZ2 TRP B 244 55.631 6.605 −23.333 1.00 16.86 B C ATOM 12410 C TRP B 244 57.951 3.241 −19.268 1.00 22.60 B C ATOM 12411 O TRP B 244 57.038 2.906 −20.023 1.00 23.08 B O ATOM 12413 N ARG B 245 58.967 2.443 −18.951 1.00 22.59 B N ATOM 12414 CA ARG B 245 59.086 1.083 −19.483 1.00 22.68 B C ATOM 12416 CB ARG B 245 60.484 0.511 −19.208 1.00 22.97 B C ATOM 12419 CG ARG B 245 61.171 −0.073 −20.439 1.00 24.49 B C ATOM 12422 CD ARG B 245 62.637 −0.418 −20.184 1.00 26.62 B C ATOM 12425 NE ARG B 245 63.364 0.675 −19.532 1.00 29.64 B N ATOM 12427 CZ ARG B 245 63.829 0.665 −18.278 1.00 32.38 B C ATOM 12428 NH1 ARG B 245 64.468 1.734 −17.808 1.00 32.81 B N ATOM 12431 NH2 ARG B 245 63.675 −0.395 −17.485 1.00 32.73 B N ATOM 12434 C ARG B 245 58.011 0.172 −18.885 1.00 22.31 B C ATOM 12435 O ARG B 245 57.367 −0.580 −19.610 1.00 22.44 B O ATOM 12437 N ARG B 246 57.825 0.255 −17.567 1.00 22.29 B N ATOM 12438 CA ARG B 246 56.787 −0.507 −16.850 1.00 22.34 B C ATOM 12440 CB ARG B 246 56.771 −0.127 −15.363 1.00 22.79 B C ATOM 12443 CG ARG B 246 57.920 −0.713 −14.543 1.00 25.55 B C ATOM 12446 CD ARG B 246 57.440 −1.710 −13.486 1.00 28.55 B C ATOM 12449 NE ARG B 246 56.772 −2.885 −14.050 1.00 30.25 B N ATOM 12451 CZ ARG B 246 56.294 −3.902 −13.330 1.00 31.54 B C ATOM 12452 NH1 ARG B 246 55.701 −4.922 −13.939 1.00 31.77 B N ATOM 12455 NH2 ARG B 246 56.406 −3.910 −12.004 1.00 32.68 B N ATOM 12458 C ARG B 246 55.395 −0.282 −17.433 1.00 21.44 B C ATOM 12459 O ARG B 246 54.664 −1.236 −17.698 1.00 21.29 B O ATOM 12461 N VAL B 247 55.031 0.985 −17.612 1.00 20.80 B N ATOM 12462 CA VAL B 247 53.776 1.340 −18.268 1.00 20.16 B C ATOM 12464 CB VAL B 247 53.602 2.872 −18.404 1.00 19.88 B C ATOM 12466 CG1 VAL B 247 53.749 3.555 −17.056 1.00 18.27 B C ATOM 12470 CG2 VAL B 247 52.252 3.203 −19.016 1.00 19.22 B C ATOM 12474 C VAL B 247 53.777 0.705 −19.653 1.00 20.35 B C ATOM 12475 O VAL B 247 52.834 0.012 −20.024 1.00 19.91 B O ATOM 12477 N GLY B 248 54.856 0.941 −20.398 1.00 20.85 B N ATOM 12478 CA GLY B 248 55.099 0.287 −21.684 1.00 21.09 B C ATOM 12481 C GLY B 248 54.039 0.561 −22.731 1.00 21.48 B C ATOM 12482 O GLY B 248 53.686 −0.327 −23.509 1.00 21.44 B O ATOM 12484 N LEU B 249 53.539 1.792 −22.763 1.00 21.90 B N ATOM 12485 CA LEU B 249 52.414 2.128 −23.633 1.00 22.39 B C ATOM 12487 CB LEU B 249 51.736 3.423 −23.164 1.00 22.22 B C ATOM 12490 CG LEU B 249 50.264 3.619 −23.549 1.00 21.67 B C ATOM 12492 CD1 LEU B 249 49.396 2.466 −23.060 1.00 19.27 B C ATOM 12496 CD2 LEU B 249 49.741 4.948 −23.007 1.00 21.26 B C ATOM 12500 C LEU B 249 52.844 2.229 −25.102 1.00 23.09 B C ATOM 12501 O LEU B 249 52.140 1.744 −25.989 1.00 23.40 B O ATOM 12503 N ALA B 250 54.004 2.837 −25.351 1.00 23.56 B N ATOM 12504 CA ALA B 250 54.523 2.999 −26.717 1.00 23.56 B C ATOM 12506 CB ALA B 250 55.778 3.867 −26.708 1.00 23.75 B C ATOM 12510 C ALA B 250 54.812 1.661 −27.406 1.00 23.27 B C ATOM 12511 O ALA B 250 54.632 1.533 −28.621 1.00 22.94 B O ATOM 12513 N THR B 251 55.261 0.677 −26.630 1.00 23.12 B N ATOM 12514 CA THR B 251 55.528 −0.665 −27.151 1.00 23.11 B C ATOM 12516 CB THR B 251 56.313 −1.525 −26.133 1.00 23.00 B C ATOM 12518 OG1 THR B 251 57.569 −0.903 −25.843 1.00 23.41 B O ATOM 12520 CG2 THR B 251 56.567 −2.922 −26.682 1.00 23.17 B C ATOM 12524 C THR B 251 54.240 −1.402 −27.518 1.00 22.91 B C ATOM 12525 O THR B 251 54.183 −2.081 −28.544 1.00 23.01 B O ATOM 12527 N LYS B 252 53.213 −1.259 −26.683 1.00 22.75 B N ATOM 12528 CA LYS B 252 51.970 −2.019 −26.843 1.00 22.97 B C ATOM 12530 CB LYS B 252 51.347 −2.303 −25.473 1.00 23.14 B C ATOM 12533 CG LYS B 252 52.249 −3.107 −24.525 1.00 23.20 B C ATOM 12536 CD LYS B 252 52.403 −4.563 −24.963 1.00 24.47 B C ATOM 12539 CE LYS B 252 53.339 −5.338 −24.041 1.00 24.49 B C ATOM 12542 NZ LYS B 252 53.670 −6.689 −24.576 1.00 23.12 B N ATOM 12546 C LYS B 252 50.949 −1.350 −27.781 1.00 23.11 B C ATOM 12547 O LYS B 252 50.186 −2.046 −28.457 1.00 23.06 B O ATOM 12549 N LEU B 253 50.931 −0.017 −27.821 1.00 23.21 B N ATOM 12550 CA LEU B 253 50.141 0.714 −28.822 1.00 23.39 B C ATOM 12552 CB LEU B 253 49.629 2.053 −28.276 1.00 23.12 B C ATOM 12555 CG LEU B 253 48.187 2.044 −27.757 1.00 22.22 B C ATOM 12557 CD1 LEU B 253 47.973 0.942 −26.728 1.00 21.08 B C ATOM 12561 CD2 LEU B 253 47.816 3.406 −27.182 1.00 19.92 B C ATOM 12565 C LEU B 253 50.979 0.927 −30.085 1.00 24.12 B C ATOM 12566 O LEU B 253 52.037 1.561 −30.041 1.00 24.39 B O ATOM 12568 N HIS B 254 50.482 0.411 −31.208 1.00 24.48 B N ATOM 12569 CA HIS B 254 51.277 0.288 −32.438 1.00 24.66 B C ATOM 12571 CB HIS B 254 50.733 −0.854 −33.312 1.00 24.99 B C ATOM 12574 CG HIS B 254 50.385 −2.093 −32.542 1.00 26.11 B C ATOM 12575 ND1 HIS B 254 51.328 −3.020 −32.152 1.00 26.40 B N ATOM 12577 CE1 HIS B 254 50.734 −3.993 −31.484 1.00 26.76 B C ATOM 12579 NE2 HIS B 254 49.441 −3.731 −31.425 1.00 27.08 B N ATOM 12581 CD2 HIS B 254 49.196 −2.548 −32.079 1.00 26.88 B C ATOM 12583 C HIS B 254 51.339 1.587 −33.248 1.00 24.42 B C ATOM 12584 O HIS B 254 52.154 1.712 −34.159 1.00 24.54 B O ATOM 12586 N PHE B 255 50.478 2.543 −32.911 1.00 24.49 B N ATOM 12587 CA PHE B 255 50.439 3.853 −33.573 1.00 24.65 B C ATOM 12589 CB PHE B 255 48.984 4.303 −33.758 1.00 24.74 B C ATOM 12592 CG PHE B 255 48.292 4.626 −32.464 1.00 24.93 B C ATOM 12593 CD1 PHE B 255 48.365 5.903 −31.919 1.00 24.68 B C ATOM 12595 CE1 PHE B 255 47.749 6.196 −30.714 1.00 25.25 B C ATOM 12597 CZ PHE B 255 47.058 5.204 −30.036 1.00 25.88 B C ATOM 12599 CE2 PHE B 255 46.985 3.925 −30.566 1.00 25.92 B C ATOM 12601 CD2 PHE B 255 47.602 3.641 −31.771 1.00 24.96 B C ATOM 12603 C PHE B 255 51.179 4.931 −32.772 1.00 24.72 B C ATOM 12604 O PHE B 255 51.506 5.988 −33.312 1.00 24.47 B O ATOM 12606 N ALA B 256 51.416 4.665 −31.485 1.00 24.97 B N ATOM 12607 CA ALA B 256 51.924 5.675 −30.551 1.00 25.20 B C ATOM 12609 CB ALA B 256 51.462 5.355 −29.132 1.00 24.99 B C ATOM 12613 C ALA B 256 53.451 5.822 −30.590 1.00 25.60 B C ATOM 12614 O ALA B 256 54.180 4.845 −30.776 1.00 25.02 B O ATOM 12616 N ARG B 257 53.911 7.058 −30.389 1.00 26.40 B N ATOM 12617 CA ARG B 257 55.329 7.410 −30.453 1.00 27.04 B C ATOM 12619 CB ARG B 257 55.511 8.768 −31.132 1.00 27.31 B C ATOM 12622 CG ARG B 257 54.920 8.884 −32.530 1.00 28.68 B C ATOM 12625 CD ARG B 257 54.737 10.347 −32.907 1.00 30.49 B C ATOM 12628 NE ARG B 257 53.733 10.999 −32.065 1.00 31.91 B N ATOM 12630 CZ ARG B 257 53.468 12.304 −32.062 1.00 31.98 B C ATOM 12631 NH1 ARG B 257 54.132 13.134 −32.860 1.00 32.59 B N ATOM 12634 NH2 ARG B 257 52.526 12.785 −31.253 1.00 30.73 B N ATOM 12637 C ARG B 257 55.952 7.496 −29.063 1.00 27.27 B C ATOM 12638 O ARG B 257 55.380 8.103 −28.153 1.00 26.70 B O ATOM 12640 N ASP B 258 57.140 6.910 −28.922 1.00 27.82 B N ATOM 12641 CA ASP B 258 57.907 6.973 −27.680 1.00 28.09 B C ATOM 12643 CB ASP B 258 58.926 5.822 −27.637 1.00 28.30 B C ATOM 12646 CG ASP B 258 59.647 5.710 −26.296 1.00 29.74 B C ATOM 12647 OD1 ASP B 258 59.515 6.623 −25.449 1.00 31.58 B O ATOM 12648 OD2 ASP B 258 60.350 4.696 −26.088 1.00 30.24 B O ATOM 12649 C ASP B 258 58.609 8.335 −27.570 1.00 27.79 B C ATOM 12650 O ASP B 258 59.694 8.529 −28.122 1.00 27.75 B O ATOM 12652 N ARG B 259 57.977 9.269 −26.859 1.00 27.57 B N ATOM 12653 CA ARG B 259 58.547 10.597 −26.621 1.00 27.44 B C ATOM 12655 CB ARG B 259 57.645 11.691 −27.212 1.00 27.68 B C ATOM 12658 CG ARG B 259 57.598 11.737 −28.736 1.00 29.41 B C ATOM 12661 CD ARG B 259 58.884 12.297 −29.341 1.00 30.97 B C ATOM 12664 NE ARG B 259 58.754 12.551 −30.778 1.00 32.99 B N ATOM 12666 CZ ARG B 259 58.787 11.616 −31.732 1.00 33.88 B C ATOM 12667 NH1 ARG B 259 58.943 10.329 −31.431 1.00 34.50 B N ATOM 12670 NH2 ARG B 259 58.657 11.972 −33.008 1.00 33.20 B N ATOM 12673 C ARG B 259 58.728 10.835 −25.124 1.00 26.73 B C ATOM 12674 O ARG B 259 57.907 11.509 −24.496 1.00 27.01 B O ATOM 12676 N LEU B 260 59.792 10.270 −24.553 1.00 25.66 B N ATOM 12677 CA LEU B 260 60.147 10.523 −23.152 1.00 24.71 B C ATOM 12679 CB LEU B 260 60.396 9.216 −22.388 1.00 24.82 B C ATOM 12682 CG LEU B 260 60.711 9.346 −20.887 1.00 23.56 B C ATOM 12684 CD1 LEU B 260 59.596 10.059 −20.139 1.00 22.57 B C ATOM 12688 CD2 LEU B 260 60.956 7.982 −20.276 1.00 22.94 B C ATOM 12692 C LEU B 260 61.381 11.411 −23.075 1.00 23.72 B C ATOM 12693 O LEU B 260 61.347 12.468 −22.445 1.00 23.35 B O ATOM 12695 N ILE B 261 62.462 10.979 −23.721 1.00 22.88 B N ATOM 12696 CA ILE B 261 63.712 11.743 −23.722 1.00 22.59 B C ATOM 12698 CB ILE B 261 64.773 11.162 −24.691 1.00 22.38 B C ATOM 12700 CG1 ILE B 261 65.102 9.705 −24.357 1.00 22.05 B C ATOM 12703 CD1 ILE B 261 66.110 9.080 −25.307 1.00 21.88 B C ATOM 12707 CG2 ILE B 261 66.056 11.987 −24.628 1.00 21.66 B C ATOM 12711 C ILE B 261 63.419 13.187 −24.125 1.00 22.69 B C ATOM 12712 O ILE B 261 63.873 14.128 −23.469 1.00 22.64 B O ATOM 12714 N GLU B 262 62.641 13.341 −25.196 1.00 22.88 B N ATOM 12715 CA GLU B 262 62.215 14.655 −25.692 1.00 22.71 B C ATOM 12717 CB GLU B 262 61.384 14.518 −26.981 1.00 22.85 B C ATOM 12720 CG GLU B 262 62.176 14.081 −28.228 1.00 23.29 B C ATOM 12723 CD GLU B 262 62.377 12.568 −28.339 1.00 23.18 B C ATOM 12724 OE1 GLU B 262 62.069 11.832 −27.375 1.00 22.88 B O ATOM 12725 OE2 GLU B 262 62.852 12.113 −29.401 1.00 22.83 B O ATOM 12726 C GLU B 262 61.397 15.397 −24.639 1.00 22.14 B C ATOM 12727 O GLU B 262 61.659 16.565 −24.346 1.00 22.04 B O ATOM 12729 N SER B 263 60.408 14.709 −24.073 1.00 21.51 B N ATOM 12730 CA SER B 263 59.561 15.292 −23.035 1.00 21.01 B C ATOM 12732 CB SER B 263 58.448 14.321 −22.627 1.00 20.92 B C ATOM 12735 OG SER B 263 57.396 14.332 −23.577 1.00 20.64 B O ATOM 12737 C SER B 263 60.356 15.721 −21.806 1.00 20.77 B C ATOM 12738 O SER B 263 59.996 16.691 −21.146 1.00 20.59 B O ATOM 12740 N PHE B 264 61.434 15.008 −21.493 1.00 21.04 B N ATOM 12741 CA PHE B 264 62.253 15.380 −20.346 1.00 21.42 B C ATOM 12743 CB PHE B 264 63.143 14.232 −19.886 1.00 21.45 B C ATOM 12746 CG PHE B 264 63.662 14.426 −18.502 1.00 21.91 B C ATOM 12747 CD1 PHE B 264 62.912 14.019 −17.408 1.00 22.62 B C ATOM 12749 CE1 PHE B 264 63.373 14.220 −16.122 1.00 23.76 B C ATOM 12751 CZ PHE B 264 64.591 14.848 −15.920 1.00 24.45 B C ATOM 12753 CE2 PHE B 264 65.337 15.273 −17.006 1.00 23.47 B C ATOM 12755 CD2 PHE B 264 64.869 15.068 −18.286 1.00 22.37 B C ATOM 12757 C PHE B 264 63.107 16.609 −20.639 1.00 21.80 B C ATOM 12758 O PHE B 264 63.236 17.496 −19.791 1.00 22.35 B O ATOM 12760 N TYR B 265 63.694 16.649 −21.833 1.00 21.65 B N ATOM 12761 CA TYR B 265 64.396 17.839 −22.327 1.00 21.35 B C ATOM 12763 CB TYR B 265 64.916 17.585 −23.747 1.00 21.73 B C ATOM 12766 CG TYR B 265 65.364 18.817 −24.494 1.00 22.81 B C ATOM 12767 CD1 TYR B 265 66.617 19.372 −24.267 1.00 24.34 B C ATOM 12769 CE1 TYR B 265 67.033 20.501 −24.954 1.00 26.45 B C ATOM 12771 CZ TYR B 265 66.192 21.083 −25.886 1.00 27.60 B C ATOM 12772 OH TYR B 265 66.601 22.202 −26.573 1.00 30.92 B O ATOM 12774 CE2 TYR B 265 64.944 20.544 −26.133 1.00 26.49 B C ATOM 12776 CD2 TYR B 265 64.539 19.417 −25.440 1.00 24.55 B C ATOM 12778 C TYR B 265 63.481 19.070 −22.292 1.00 20.55 B C ATOM 12779 O TYR B 265 63.923 20.176 −21.983 1.00 20.24 B O ATOM 12781 N TRP B 266 62.207 18.859 −22.610 1.00 20.01 B N ATOM 12782 CA TRP B 266 61.183 19.894 −22.484 1.00 19.27 B C ATOM 12784 CB TRP B 266 59.834 19.354 −22.972 1.00 19.17 B C ATOM 12787 CG TRP B 266 58.709 20.327 −22.879 1.00 19.53 B C ATOM 12788 CD1 TRP B 266 57.867 20.512 −21.820 1.00 19.29 B C ATOM 12790 NE1 TRP B 266 56.955 21.496 −22.107 1.00 18.94 B N ATOM 12792 CE2 TRP B 266 57.190 21.963 −23.373 1.00 20.47 B C ATOM 12793 CD2 TRP B 266 58.291 21.246 −23.891 1.00 21.23 B C ATOM 12794 CE3 TRP B 266 58.742 21.537 −25.184 1.00 22.28 B C ATOM 12796 CZ3 TRP B 266 58.087 22.520 −25.911 1.00 22.69 B C ATOM 12798 CH2 TRP B 266 56.996 23.218 −25.367 1.00 22.30 B C ATOM 12800 CZ2 TRP B 266 56.532 22.953 −24.105 1.00 20.82 B C ATOM 12802 C TRP B 266 61.069 20.374 −21.039 1.00 18.58 B C ATOM 12803 O TRP B 266 61.049 21.579 −20.779 1.00 18.53 B O ATOM 12805 N ALA B 267 61.003 19.422 −20.109 1.00 18.04 B N ATOM 12806 CA ALA B 267 60.846 19.721 −18.680 1.00 17.48 B C ATOM 12808 CB ALA B 267 60.644 18.432 −17.888 1.00 17.29 B C ATOM 12812 C ALA B 267 62.024 20.507 −18.111 1.00 16.68 B C ATOM 12813 O ALA B 267 61.834 21.408 −17.294 1.00 16.12 B O ATOM 12815 N VAL B 268 63.233 20.169 −18.556 1.00 16.04 B N ATOM 12816 CA VAL B 268 64.451 20.840 −18.094 1.00 15.90 B C ATOM 12818 CB VAL B 268 65.713 20.172 −18.685 1.00 15.88 B C ATOM 12820 CG1 VAL B 268 65.880 18.777 −18.105 1.00 16.89 B C ATOM 12824 CG2 VAL B 268 66.954 21.001 −18.414 1.00 14.94 B C ATOM 12828 C VAL B 268 64.444 22.339 −18.411 1.00 15.83 B C ATOM 12829 O VAL B 268 65.068 23.131 −17.707 1.00 15.84 B O ATOM 12831 N GLY B 269 63.736 22.725 −19.467 1.00 16.01 B N ATOM 12832 CA GLY B 269 63.520 24.136 −19.768 1.00 16.02 B C ATOM 12835 C GLY B 269 62.558 24.781 −18.788 1.00 15.89 B C ATOM 12836 O GLY B 269 62.710 25.952 −18.440 1.00 15.72 B O ATOM 12838 N VAL B 270 61.570 24.009 −18.341 1.00 15.89 B N ATOM 12839 CA VAL B 270 60.537 24.512 −17.439 1.00 15.75 B C ATOM 12841 CB VAL B 270 59.329 23.550 −17.364 1.00 15.72 B C ATOM 12843 CG1 VAL B 270 58.227 24.145 −16.505 1.00 15.52 B C ATOM 12847 CG2 VAL B 270 58.806 23.239 −18.759 1.00 15.42 B C ATOM 12851 C VAL B 270 61.098 24.728 −16.039 1.00 15.62 B C ATOM 12852 O VAL B 270 60.970 25.815 −15.481 1.00 15.95 B O ATOM 12854 N ALA B 271 61.724 23.692 −15.485 1.00 15.73 B N ATOM 12855 CA ALA B 271 62.301 23.756 −14.140 1.00 16.08 B C ATOM 12857 CB ALA B 271 61.403 23.033 −13.156 1.00 15.92 B C ATOM 12861 C ALA B 271 63.712 23.166 −14.108 1.00 16.48 B C ATOM 12862 O ALA B 271 63.898 21.987 −13.792 1.00 16.03 B O ATOM 12864 N PHE B 272 64.701 23.996 −14.435 1.00 17.15 B N ATOM 12865 CA PHE B 272 66.098 23.560 −14.476 1.00 17.81 B C ATOM 12867 CB PHE B 272 66.968 24.549 −15.268 1.00 18.10 B C ATOM 12870 CG PHE B 272 67.219 25.853 −14.557 1.00 19.12 B C ATOM 12871 CD1 PHE B 272 68.266 25.978 −13.654 1.00 18.88 B C ATOM 12873 CE1 PHE B 272 68.498 27.177 −12.995 1.00 20.29 B C ATOM 12875 CZ PHE B 272 67.688 28.273 −13.242 1.00 20.78 B C ATOM 12877 CE2 PHE B 272 66.645 28.166 −14.146 1.00 21.63 B C ATOM 12879 CD2 PHE B 272 66.414 26.960 −14.799 1.00 21.22 B C ATOM 12881 C PHE B 272 66.681 23.371 −13.082 1.00 18.23 B C ATOM 12882 O PHE B 272 67.510 22.486 −12.871 1.00 18.10 B O ATOM 12884 N GLU B 273 66.246 24.206 −12.138 1.00 18.89 B N ATOM 12885 CA GLU B 273 66.821 24.230 −10.792 1.00 19.04 B C ATOM 12887 CB GLU B 273 66.053 25.189 −9.870 1.00 19.05 B C ATOM 12890 CG GLU B 273 66.068 26.665 −10.295 1.00 19.59 B C ATOM 12893 CD GLU B 273 64.917 27.047 −11.222 1.00 22.44 B C ATOM 12894 OE1 GLU B 273 64.464 28.210 −11.163 1.00 24.11 B O ATOM 12895 OE2 GLU B 273 64.460 26.190 −12.009 1.00 24.79 B O ATOM 12896 C GLU B 273 66.826 22.809 −10.215 1.00 18.87 B C ATOM 12897 O GLU B 273 65.801 22.129 −10.257 1.00 19.19 B O ATOM 12899 N PRO B 274 67.985 22.349 −9.701 1.00 18.78 B N ATOM 12900 CA PRO B 274 68.155 20.957 −9.253 1.00 18.78 B C ATOM 12902 CB PRO B 274 69.478 20.999 −8.479 1.00 18.81 B C ATOM 12905 CG PRO B 274 70.229 22.113 −9.082 1.00 18.95 B C ATOM 12908 CD PRO B 274 69.231 23.127 −9.550 1.00 18.65 B C ATOM 12911 C PRO B 274 67.037 20.428 −8.351 1.00 18.44 B C ATOM 12912 O PRO B 274 66.501 19.347 −8.599 1.00 18.00 B O ATOM 12913 N GLN B 275 66.704 21.197 −7.320 1.00 18.53 B N ATOM 12914 CA GLN B 275 65.679 20.831 −6.339 1.00 18.90 B C ATOM 12916 CB GLN B 275 65.475 21.976 −5.332 1.00 19.10 B C ATOM 12919 CG GLN B 275 65.092 23.339 −5.936 1.00 19.30 B C ATOM 12922 CD GLN B 275 66.298 24.200 −6.290 1.00 19.15 B C ATOM 12923 OE1 GLN B 275 67.237 23.734 −6.933 1.00 19.04 B O ATOM 12924 NE2 GLN B 275 66.270 25.462 −5.877 1.00 19.96 B N ATOM 12927 C GLN B 275 64.318 20.404 −6.925 1.00 19.09 B C ATOM 12928 O GLN B 275 63.643 19.549 −6.347 1.00 19.14 B O ATOM 12930 N TYR B 276 63.924 20.979 −8.062 1.00 19.13 B N ATOM 12931 CA TYR B 276 62.625 20.672 −8.679 1.00 18.93 B C ATOM 12933 CB TYR B 276 62.170 21.817 −9.598 1.00 18.94 B C ATOM 12936 CG TYR B 276 62.067 23.177 −8.941 1.00 19.74 B C ATOM 12937 CD1 TYR B 276 61.362 23.352 −7.755 1.00 20.43 B C ATOM 12939 CE1 TYR B 276 61.263 24.600 −7.159 1.00 20.81 B C ATOM 12941 CZ TYR B 276 61.858 25.692 −7.759 1.00 20.24 B C ATOM 12942 OH TYR B 276 61.757 26.929 −7.173 1.00 23.88 B O ATOM 12944 CE2 TYR B 276 62.551 25.550 −8.942 1.00 18.69 B C ATOM 12946 CD2 TYR B 276 62.647 24.299 −9.529 1.00 19.51 B C ATOM 12948 C TYR B 276 62.646 19.371 −9.489 1.00 18.68 B C ATOM 12949 O TYR B 276 62.344 19.376 −10.681 1.00 18.82 B O ATOM 12951 N SER B 277 62.983 18.256 −8.848 1.00 18.35 B N ATOM 12952 CA SER B 277 62.984 16.961 −9.534 1.00 17.80 B C ATOM 12954 CB SER B 277 63.829 15.938 −8.774 1.00 17.69 B C ATOM 12957 OG SER B 277 65.212 16.219 −8.923 1.00 16.37 B O ATOM 12959 C SER B 277 61.558 16.449 −9.743 1.00 17.75 B C ATOM 12960 O SER B 277 61.257 15.869 −10.783 1.00 17.82 B O ATOM 12962 N ASP B 278 60.687 16.675 −8.761 1.00 17.90 B N ATOM 12963 CA ASP B 278 59.267 16.323 −8.881 1.00 17.97 B C ATOM 12965 CB ASP B 278 58.493 16.711 −7.618 1.00 18.01 B C ATOM 12968 CG ASP B 278 58.951 15.960 −6.390 1.00 18.66 B C ATOM 12969 OD1 ASP B 278 59.518 14.860 −6.537 1.00 22.13 B O ATOM 12970 OD2 ASP B 278 58.740 16.473 −5.271 1.00 20.36 B O ATOM 12971 C ASP B 278 58.620 17.019 −10.073 1.00 18.09 B C ATOM 12972 O ASP B 278 57.855 16.404 −10.813 1.00 18.35 B O ATOM 12974 N CYS B 279 58.919 18.303 −10.246 1.00 18.18 B N ATOM 12975 CA CYS B 279 58.366 19.077 −11.356 1.00 18.27 B C ATOM 12977 CB CYS B 279 58.847 20.538 −11.302 1.00 18.30 B C ATOM 12980 SG CYS B 279 57.937 21.699 −12.374 1.00 16.99 B S ATOM 12982 C CYS B 279 58.758 18.423 −12.676 1.00 18.44 B C ATOM 12983 O CYS B 279 57.897 18.121 −13.503 1.00 18.24 B O ATOM 12985 N ARG B 280 60.055 18.178 −12.846 1.00 18.78 B N ATOM 12986 CA ARG B 280 60.576 17.556 −14.063 1.00 18.99 B C ATOM 12988 CB ARG B 280 62.096 17.386 −13.978 1.00 19.18 B C ATOM 12991 CG ARG B 280 62.866 18.702 −14.057 1.00 20.22 B C ATOM 12994 CD ARG B 280 64.364 18.482 −14.244 1.00 20.99 B C ATOM 12997 NE ARG B 280 65.004 17.940 −13.047 1.00 20.45 B N ATOM 12999 CZ ARG B 280 65.341 18.652 −11.972 1.00 22.60 B C ATOM 13000 NH1 ARG B 280 65.098 19.959 −11.908 1.00 22.84 B N ATOM 13003 NH2 ARG B 280 65.923 18.046 −10.942 1.00 24.41 B N ATOM 13006 C ARG B 280 59.906 16.212 −14.339 1.00 18.84 B C ATOM 13007 O ARG B 280 59.427 15.973 −15.447 1.00 19.34 B O ATOM 13009 N ASN B 281 59.852 15.352 −13.326 1.00 18.40 B N ATOM 13010 CA ASN B 281 59.227 14.034 −13.468 1.00 18.38 B C ATOM 13012 CB ASN B 281 59.559 13.146 −12.266 1.00 18.31 B C ATOM 13015 CG ASN B 281 61.055 12.921 −12.103 1.00 19.38 B C ATOM 13016 OD1 ASN B 281 61.851 13.291 −12.969 1.00 18.81 B O ATOM 13017 ND2 ASN B 281 61.445 12.317 −10.985 1.00 21.51 B N ATOM 13020 C ASN B 281 57.710 14.109 −13.672 1.00 18.30 B C ATOM 13021 O ASN B 281 57.126 13.240 −14.317 1.00 18.27 B O ATOM 13023 N SER B 282 57.078 15.150 −13.132 1.00 17.93 B N ATOM 13024 CA SER B 282 55.651 15.378 −13.352 1.00 17.39 B C ATOM 13026 CB SER B 282 55.106 16.395 −12.340 1.00 17.68 B C ATOM 13029 OG SER B 282 53.687 16.431 −12.343 1.00 18.53 B O ATOM 13031 C SER B 282 55.410 15.861 −14.786 1.00 16.41 B C ATOM 13032 O SER B 282 54.649 15.251 −15.535 1.00 15.72 B O ATOM 13034 N VAL B 283 56.083 16.944 −15.167 1.00 15.82 B N ATOM 13035 CA VAL B 283 55.893 17.546 −16.489 1.00 15.38 B C ATOM 13037 CB VAL B 283 56.678 18.871 −16.635 1.00 15.03 B C ATOM 13039 CG1 VAL B 283 56.610 19.388 −18.066 1.00 13.71 B C ATOM 13043 CG2 VAL B 283 56.136 19.912 −15.669 1.00 13.54 B C ATOM 13047 C VAL B 283 56.289 16.584 −17.607 1.00 15.75 B C ATOM 13048 O VAL B 283 55.608 16.504 −18.627 1.00 15.73 B O ATOM 13050 N ALA B 284 57.381 15.852 −17.410 1.00 16.23 B N ATOM 13051 CA ALA B 284 57.811 14.857 −18.387 1.00 16.83 B C ATOM 13053 CB ALA B 284 59.098 14.185 −17.939 1.00 16.69 B C ATOM 13057 C ALA B 284 56.713 13.818 −18.592 1.00 17.70 B C ATOM 13058 O ALA B 284 56.235 13.629 −19.712 1.00 17.70 B O ATOM 13060 N LYS B 285 56.311 13.170 −17.497 1.00 18.64 B N ATOM 13061 CA LYS B 285 55.259 12.146 −17.518 1.00 18.83 B C ATOM 13063 CB LYS B 285 54.860 11.750 −16.089 1.00 18.82 B C ATOM 13066 CG LYS B 285 55.795 10.749 −15.431 1.00 20.25 B C ATOM 13069 CD LYS B 285 55.419 10.498 −13.974 1.00 22.25 B C ATOM 13072 CE LYS B 285 56.438 9.597 −13.279 1.00 23.50 B C ATOM 13075 NZ LYS B 285 56.327 9.653 −11.792 1.00 23.56 B N ATOM 13079 C LYS B 285 54.015 12.604 −18.274 1.00 18.88 B C ATOM 13080 O LYS B 285 53.524 11.895 −19.151 1.00 18.86 B O ATOM 13082 N MET B 286 53.518 13.790 −17.932 1.00 19.06 B N ATOM 13083 CA MET B 286 52.272 14.299 −18.506 1.00 19.32 B C ATOM 13085 CB MET B 286 51.853 15.601 −17.818 1.00 19.40 B C ATOM 13088 CG MET B 286 51.483 15.460 −16.350 1.00 19.99 B C ATOM 13091 SD MET B 286 50.219 14.220 −16.032 1.00 21.41 B S ATOM 13092 CE MET B 286 51.231 12.784 −15.666 1.00 21.45 B C ATOM 13096 C MET B 286 52.379 14.535 −20.010 1.00 19.39 B C ATOM 13097 O MET B 286 51.486 14.152 −20.769 1.00 19.62 B O ATOM 13099 N PHE B 287 53.474 15.163 −20.429 1.00 19.05 B N ATOM 13100 CA PHE B 287 53.684 15.501 −21.835 1.00 18.49 B C ATOM 13102 CB PHE B 287 54.845 16.499 −21.969 1.00 18.88 B C ATOM 13105 CG PHE B 287 54.942 17.161 −23.320 1.00 19.92 B C ATOM 13106 CD1 PHE B 287 53.805 17.632 −23.977 1.00 20.75 B C ATOM 13108 CE1 PHE B 287 53.899 18.243 −25.217 1.00 20.58 B C ATOM 13110 CZ PHE B 287 55.136 18.405 −25.812 1.00 23.37 B C ATOM 13112 CE2 PHE B 287 56.280 17.952 −25.165 1.00 23.28 B C ATOM 13114 CD2 PHE B 287 56.178 17.338 −23.925 1.00 21.35 B C ATOM 13116 C PHE B 287 53.919 14.250 −22.690 1.00 17.56 B C ATOM 13117 O PHE B 287 53.564 14.231 −23.869 1.00 17.16 B O ATOM 13119 N SER B 288 54.503 13.209 −22.096 1.00 16.87 B N ATOM 13120 CA SER B 288 54.594 11.903 −22.757 1.00 16.53 B C ATOM 13122 CB SER B 288 55.368 10.891 −21.904 1.00 16.55 B C ATOM 13125 OG SER B 288 56.768 11.116 −21.970 1.00 16.74 B O ATOM 13127 C SER B 288 53.195 11.374 −23.045 1.00 16.36 B C ATOM 13128 O SER B 288 52.902 10.956 −24.165 1.00 16.74 B O ATOM 13130 N PHE B 289 52.331 11.406 −22.034 1.00 16.08 B N ATOM 13131 CA PHE B 289 50.930 11.029 −22.214 1.00 15.77 B C ATOM 13133 CB PHE B 289 50.171 11.038 −20.878 1.00 15.73 B C ATOM 13136 CG PHE B 289 50.321 9.767 −20.087 1.00 16.79 B C ATOM 13137 CD1 PHE B 289 49.832 8.564 −20.585 1.00 18.35 B C ATOM 13139 CE1 PHE B 289 49.966 7.384 −19.864 1.00 17.92 B C ATOM 13141 CZ PHE B 289 50.591 7.399 −18.628 1.00 18.05 B C ATOM 13143 CE2 PHE B 289 51.081 8.591 −18.119 1.00 18.22 B C ATOM 13145 CD2 PHE B 289 50.943 9.768 −18.846 1.00 17.63 B C ATOM 13147 C PHE B 289 50.225 11.930 −23.229 1.00 15.42 B C ATOM 13148 O PHE B 289 49.437 11.445 −24.039 1.00 15.46 B O ATOM 13150 N VAL B 290 50.517 13.230 −23.193 1.00 15.19 B N ATOM 13151 CA VAL B 290 49.908 14.179 −24.133 1.00 14.81 B C ATOM 13153 CB VAL B 290 50.383 15.639 −23.905 1.00 14.27 B C ATOM 13155 CG1 VAL B 290 49.790 16.565 −24.954 1.00 11.43 B C ATOM 13159 CG2 VAL B 290 50.002 16.118 −22.521 1.00 13.72 B C ATOM 13163 C VAL B 290 50.194 13.784 −25.583 1.00 15.49 B C ATOM 13164 O VAL B 290 49.276 13.740 −26.402 1.00 15.62 B O ATOM 13166 N THR B 291 51.455 13.476 −25.893 1.00 15.62 B N ATOM 13167 CA THR B 291 51.838 13.155 −27.273 1.00 15.90 B C ATOM 13169 CB THR B 291 53.367 12.948 −27.445 1.00 15.92 B C ATOM 13171 OG1 THR B 291 53.781 11.762 −26.759 1.00 17.87 B O ATOM 13173 CG2 THR B 291 54.150 14.145 −26.917 1.00 16.50 B C ATOM 13177 C THR B 291 51.109 11.914 −27.786 1.00 15.66 B C ATOM 13178 O THR B 291 50.809 11.818 −28.977 1.00 15.78 B O ATOM 13180 N ILE B 292 50.824 10.977 −26.882 1.00 15.54 B N ATOM 13181 CA ILE B 292 50.114 9.743 −27.228 1.00 15.38 B C ATOM 13183 CB ILE B 292 50.331 8.650 −26.160 1.00 15.32 B C ATOM 13185 CG1 ILE B 292 51.803 8.234 −26.129 1.00 13.86 B C ATOM 13188 CD1 ILE B 292 52.103 7.171 −25.111 1.00 13.47 B C ATOM 13192 CG2 ILE B 292 49.446 7.434 −26.437 1.00 15.16 B C ATOM 13196 C ILE B 292 48.612 9.978 −27.426 1.00 15.28 B C ATOM 13197 O ILE B 292 48.023 9.462 −28.379 1.00 15.27 B O ATOM 13199 N ILE B 293 47.997 10.749 −26.531 1.00 14.89 B N ATOM 13200 CA ILE B 293 46.580 11.079 −26.672 1.00 14.80 B C ATOM 13202 CB ILE B 293 46.012 11.832 −25.453 1.00 14.64 B C ATOM 13204 CG1 ILE B 293 46.094 10.979 −24.184 1.00 14.55 B C ATOM 13207 CD1 ILE B 293 45.101 9.846 −24.144 1.00 14.32 B C ATOM 13211 CG2 ILE B 293 44.558 12.203 −25.700 1.00 14.22 B C ATOM 13215 C ILE B 293 46.394 11.938 −27.916 1.00 15.23 B C ATOM 13216 O ILE B 293 45.466 11.724 −28.691 1.00 15.35 B O ATOM 13218 N ASP B 294 47.291 12.901 −28.110 1.00 15.94 B N ATOM 13219 CA ASP B 294 47.273 13.739 −29.313 1.00 16.55 B C ATOM 13221 CB ASP B 294 48.491 14.682 −29.346 1.00 17.12 B C ATOM 13224 CG ASP B 294 48.314 15.858 −30.307 1.00 17.49 B C ATOM 13225 OD1 ASP B 294 47.164 16.220 −30.634 1.00 17.71 B O ATOM 13226 OD2 ASP B 294 49.342 16.437 −30.720 1.00 18.55 B O ATOM 13227 C ASP B 294 47.239 12.861 −30.564 1.00 16.11 B C ATOM 13228 O ASP B 294 46.495 13.144 −31.495 1.00 16.16 B O ATOM 13230 N ASP B 295 48.029 11.788 −30.567 1.00 15.75 B N ATOM 13231 CA ASP B 295 48.006 10.816 −31.663 1.00 15.80 B C ATOM 13233 CB ASP B 295 49.092 9.750 −31.481 1.00 15.85 B C ATOM 13236 CG ASP B 295 50.462 10.218 −31.932 1.00 15.72 B C ATOM 13237 OD1 ASP B 295 50.570 11.306 −32.536 1.00 16.90 B O ATOM 13238 OD2 ASP B 295 51.440 9.486 −31.684 1.00 13.67 B O ATOM 13239 C ASP B 295 46.650 10.132 −31.797 1.00 15.95 B C ATOM 13240 O ASP B 295 46.149 9.960 −32.911 1.00 16.24 B O ATOM 13242 N ILE B 296 46.063 9.738 −30.668 1.00 15.64 B N ATOM 13243 CA ILE B 296 44.754 9.080 −30.674 1.00 15.06 B C ATOM 13245 CB ILE B 296 44.270 8.738 −29.251 1.00 14.85 B C ATOM 13247 CG1 ILE B 296 45.067 7.558 −28.699 1.00 14.95 B C ATOM 13250 CD1 ILE B 296 44.747 7.211 −27.266 1.00 15.45 B C ATOM 13254 CG2 ILE B 296 42.795 8.378 −29.263 1.00 15.55 B C ATOM 13258 C ILE B 296 43.696 9.932 −31.365 1.00 14.52 B C ATOM 13259 O ILE B 296 43.010 9.462 −32.269 1.00 14.11 B O ATOM 13261 N TYR B 297 43.579 11.185 −30.941 1.00 14.55 B N ATOM 13262 CA TYR B 297 42.557 12.089 −31.471 1.00 14.75 B C ATOM 13264 CB TYR B 297 42.392 13.311 −30.558 1.00 14.65 B C ATOM 13267 CG TYR B 297 41.605 13.051 −29.288 1.00 13.97 B C ATOM 13268 CD1 TYR B 297 40.311 13.543 −29.132 1.00 15.04 B C ATOM 13270 CE1 TYR B 297 39.586 13.315 −27.963 1.00 15.12 B C ATOM 13272 CZ TYR B 297 40.157 12.584 −26.938 1.00 16.10 B C ATOM 13273 OH TYR B 297 39.452 12.349 −25.781 1.00 17.13 B O ATOM 13275 CE2 TYR B 297 41.439 12.086 −27.070 1.00 16.03 B C ATOM 13277 CD2 TYR B 297 42.156 12.322 −28.240 1.00 15.06 B C ATOM 13279 C TYR B 297 42.869 12.545 −32.898 1.00 14.81 B C ATOM 13280 O TYR B 297 41.995 12.524 −33.770 1.00 14.70 B O ATOM 13282 N ASP B 298 44.117 12.946 −33.125 1.00 14.76 B N ATOM 13283 CA ASP B 298 44.529 13.551 −34.391 1.00 14.85 B C ATOM 13285 CB ASP B 298 46.011 13.965 −34.327 1.00 15.56 B C ATOM 13288 CG ASP B 298 46.436 14.845 −35.495 1.00 16.94 B C ATOM 13289 OD1 ASP B 298 45.717 15.822 −35.798 1.00 19.66 B O ATOM 13290 OD2 ASP B 298 47.500 14.571 −36.096 1.00 16.83 B O ATOM 13291 C ASP B 298 44.298 12.621 −35.579 1.00 13.99 B C ATOM 13292 O ASP B 298 43.653 13.011 −36.552 1.00 13.35 B O ATOM 13294 N VAL B 299 44.813 11.395 −35.487 1.00 13.69 B N ATOM 13295 CA VAL B 299 44.819 10.467 −36.629 1.00 13.50 B C ATOM 13297 CB VAL B 299 46.263 10.201 −37.129 1.00 13.48 B C ATOM 13299 CG1 VAL B 299 46.901 11.491 −37.614 1.00 14.14 B C ATOM 13303 CG2 VAL B 299 47.111 9.556 −36.038 1.00 13.60 B C ATOM 13307 C VAL B 299 44.139 9.112 −36.404 1.00 12.90 B C ATOM 13308 O VAL B 299 43.543 8.574 −37.336 1.00 12.78 B O ATOM 13310 N TYR B 300 44.217 8.563 −35.192 1.00 12.41 B N ATOM 13311 CA TYR B 300 43.884 7.149 −34.976 1.00 12.41 B C ATOM 13313 CB TYR B 300 44.802 6.549 −33.911 1.00 12.27 B C ATOM 13316 CG TYR B 300 44.709 5.041 −33.826 1.00 12.47 B C ATOM 13317 CD1 TYR B 300 45.090 4.241 −34.898 1.00 11.58 B C ATOM 13319 CE1 TYR B 300 45.005 2.858 −34.831 1.00 10.77 B C ATOM 13321 CZ TYR B 300 44.535 2.258 −33.681 1.00 10.71 B C ATOM 13322 OH TYR B 300 44.451 O.888 −33.608 1.00 11.57 B O ATOM 13324 CE2 TYR B 300 44.150 3.027 −32.602 1.00 13.01 B C ATOM 13326 CD2 TYR B 300 44.237 4.415 −32.679 1.00 13.92 B C ATOM 13328 C TYR B 300 42.420 6.833 −34.624 1.00 12.63 B C ATOM 13329 O TYR B 300 41.804 5.979 −35.259 1.00 12.91 B O ATOM 13331 N GLY B 301 41.869 7.496 −33.614 1.00 12.74 B N ATOM 13332 CA GLY B 301 40.531 7.156 −33.118 1.00 12.64 B C ATOM 13335 C GLY B 301 39.382 7.678 −33.966 1.00 12.49 B C ATOM 13336 O GLY B 301 39.498 8.719 −34.613 1.00 12.57 B O ATOM 13338 N THR B 302 38.265 6.951 −33.957 1.00 12.36 B N ATOM 13339 CA THR B 302 37.033 7.433 −34.579 1.00 12.60 B C ATOM 13341 CB THR B 302 36.010 6.307 −34.834 1.00 12.31 B C ATOM 13343 OG1 THR B 302 35.511 5.810 −33.587 1.00 11.75 B O ATOM 13345 CG2 THR B 302 36.631 5.171 −35.624 1.00 12.44 B C ATOM 13349 C THR B 302 36.391 8.449 −33.653 1.00 13.44 B C ATOM 13350 O THR B 302 36.764 8.556 −32.487 1.00 13.63 B O ATOM 13352 N LEU B 303 35.408 9.181 −34.166 1.00 14.23 B N ATOM 13353 CA LEU B 303 34.732 10.205 −33.373 1.00 14.47 B C ATOM 13355 CB LEU B 303 33.758 11.004 −34.239 1.00 14.69 B C ATOM 13358 CG LEU B 303 33.460 12.428 −33.775 1.00 14.65 B C ATOM 13360 CD1 LEU B 303 34.684 13.310 −33.959 1.00 13.80 B C ATOM 13364 CD2 LEU B 303 32.268 12.988 −34.544 1.00 16.81 B C ATOM 13368 C LEU B 303 33.998 9.573 −32.192 1.00 14.67 B C ATOM 13369 O LEU B 303 34.065 10.082 −31.075 1.00 14.67 B O ATOM 13371 N ASP B 304 33.311 8.460 −32.449 1.00 15.27 B N ATOM 13372 CA ASP B 304 32.630 7.694 −31.395 1.00 15.80 B C ATOM 13374 CB ASP B 304 31.828 6.523 −31.991 1.00 16.12 B C ATOM 13377 CG ASP B 304 30.537 6.966 −32.668 1.00 16.23 B C ATOM 13378 OD1 ASP B 304 30.252 8.183 −32.707 1.00 17.00 B O ATOM 13379 OD2 ASP B 304 29.803 6.086 −33.165 1.00 15.17 B O ATOM 13380 C ASP B 304 33.617 7.155 −30.356 1.00 15.75 B C ATOM 13381 O ASP B 304 33.332 7.168 −29.154 1.00 15.68 B O ATOM 13383 N GLU B 305 34.765 6.669 −30.823 1.00 15.44 B N ATOM 13384 CA GLU B 305 35.823 6.207 −29.926 1.00 15.31 B C ATOM 13386 CB GLU B 305 36.965 5.564 −30.713 1.00 15.57 B C ATOM 13389 CG GLU B 305 36.689 4.138 −31.162 1.00 15.98 B C ATOM 13392 CD GLU B 305 37.800 3.581 −32.027 1.00 16.46 B C ATOM 13393 OE1 GLU B 305 38.399 4.350 −32.807 1.00 17.84 B O ATOM 13394 OE2 GLU B 305 38.076 2.369 −31.936 1.00 17.97 B O ATOM 13395 C GLU B 305 36.366 7.357 −29.088 1.00 15.04 B C ATOM 13396 O GLU B 305 36.621 7.190 −27.895 1.00 15.15 B O ATOM 13398 N LEU B 306 36.536 8.518 −29.720 1.00 14.77 B N ATOM 13399 CA LEU B 306 37.040 9.715 −29.040 1.00 13.94 B C ATOM 13401 CB LEU B 306 37.447 10.778 −30.064 1.00 13.32 B C ATOM 13404 CG LEU B 306 38.667 10.392 −30.903 1.00 11.95 B C ATOM 13406 CD1 LEU B 306 38.892 11.372 −32.041 1.00 9.49 B C ATOM 13410 CD2 LEU B 306 39.897 10.287 −30.018 1.00 12.30 B C ATOM 13414 C LEU B 306 36.024 10.283 −28.050 1.00 14.05 B C ATOM 13415 O LEU B 306 36.405 10.817 −27.007 1.00 13.84 B O ATOM 13417 N GLU B 307 34.739 10.159 −28.374 1.00 14.32 B N ATOM 13418 CA GLU B 307 33.672 10.542 −27.448 1.00 14.91 B C ATOM 13420 CB GLU B 307 32.296 10.437 −28.119 1.00 15.01 B C ATOM 13423 CG GLU B 307 31.885 11.687 −28.890 1.00 16.39 B C ATOM 13426 CD GLU B 307 31.587 12.875 −27.985 1.00 18.17 B C ATOM 13427 OE1 GLU B 307 31.715 14.025 −28.455 1.00 18.84 B O ATOM 13428 OE2 GLU B 307 31.227 12.662 −26.805 1.00 19.10 B O ATOM 13429 C GLU B 307 33.695 9.709 −26.164 1.00 15.05 B C ATOM 13430 O GLU B 307 33.545 10.256 −25.070 1.00 15.50 B O ATOM 13432 N LEU B 308 33.883 8.395 −26.299 1.00 14.90 B N ATOM 13433 CA LEU B 308 33.941 7.501 −25.136 1.00 14.90 B C ATOM 13435 CB LEU B 308 33.975 6.027 −25.562 1.00 15.03 B C ATOM 13438 CG LEU B 308 32.705 5.409 −26.151 1.00 15.09 B C ATOM 13440 CD1 LEU B 308 32.922 3.918 −26.391 1.00 12.37 B C ATOM 13444 CD2 LEU B 308 31.503 5.640 −25.244 1.00 14.58 B C ATOM 13448 C LEU B 308 35.144 7.794 −24.244 1.00 14.76 B C ATOM 13449 O LEU B 308 35.047 7.693 −23.023 1.00 14.83 B O ATOM 13451 N PHE B 309 36.272 8.148 −24.854 1.00 14.97 B N ATOM 13452 CA PHE B 309 37.482 8.481 −24.102 1.00 15.23 B C ATOM 13454 CB PHE B 309 38.701 8.540 −25.030 1.00 14.93 B C ATOM 13457 CG PHE B 309 40.014 8.476 −24.303 1.00 12.81 B C ATOM 13458 CD1 PHE B 309 40.712 7.280 −24.213 1.00 10.56 B C ATOM 13460 CE1 PHE B 309 41.919 7.212 −23.537 1.00 9.68 B C ATOM 13462 CZ PHE B 309 42.440 8.345 −22.941 1.00 10.55 B C ATOM 13464 CE2 PHE B 309 41.752 9.550 −23.020 1.00 11.50 B C ATOM 13466 CD2 PHE B 309 40.547 9.610 −23.698 1.00 11.86 B C ATOM 13468 C PHE B 309 37.318 9.815 −23.361 1.00 16.02 B C ATOM 13469 O PHE B 309 37.597 9.905 −22.162 1.00 16.16 B O ATOM 13471 N THR B 310 36.876 10.843 −24.083 1.00 16.42 B N ATOM 13472 CA THR B 310 36.594 12.144 −23.484 1.00 16.93 B C ATOM 13474 CB THR B 310 35.941 13.101 −24.499 1.00 17.11 B C ATOM 13476 OG1 THR B 310 36.753 13.182 −25.676 1.00 18.04 B O ATOM 13478 CG2 THR B 310 35.775 14.490 −23.898 1.00 17.27 B C ATOM 13482 C THR B 310 35.645 11.970 −22.306 1.00 17.22 B C ATOM 13483 O THR B 310 35.893 12.475 −21.213 1.00 17.31 B O ATOM 13485 N ASP B 311 34.560 11.242 −22.549 1.00 17.64 B N ATOM 13486 CA ASP B 311 33.559 10.957 −21.529 1.00 18.02 B C ATOM 13488 CB ASP B 311 32.432 10.119 −22.136 1.00 17.98 B C ATOM 13491 CG ASP B 311 31.441 9.638 −21.103 1.00 18.70 B C ATOM 13492 OD1 ASP B 311 30.851 10.486 −20.399 1.00 19.29 B O ATOM 13493 OD2 ASP B 311 31.251 8.407 −20.997 1.00 21.03 B O ATOM 13494 C ASP B 311 34.160 10.228 −20.326 1.00 18.33 B C ATOM 13495 O ASP B 311 33.934 10.624 −19.182 1.00 18.39 B O ATOM 13497 N ALA B 312 34.925 9.170 −20.597 1.00 18.50 B N ATOM 13498 CA ALA B 312 35.524 8.335 −19.548 1.00 18.23 B C ATOM 13500 CB ALA B 312 36.268 7.159 −20.168 1.00 18.14 B C ATOM 13504 C ALA B 312 36.456 9.117 −18.625 1.00 18.16 B C ATOM 13505 O ALA B 312 36.513 8.845 −17.426 1.00 18.48 B O ATOM 13507 N VAL B 313 37.183 10.079 −19.189 1.00 18.03 B N ATOM 13508 CA VAL B 313 38.050 10.960 −18.405 1.00 18.31 B C ATOM 13510 CB VAL B 313 38.965 11.805 −19.326 1.00 18.52 B C ATOM 13512 CG1 VAL B 313 40.105 10.946 −19.870 1.00 18.57 B C ATOM 13516 CG2 VAL B 313 39.515 13.021 −18.588 1.00 18.51 B C ATOM 13520 C VAL B 313 37.240 11.882 −17.486 1.00 18.58 B C ATOM 13521 O VAL B 313 37.553 12.016 −16.303 1.00 18.04 B O ATOM 13523 N GLU B 314 36.198 12.504 −18.033 1.00 19.37 B N ATOM 13524 CA GLU B 314 35.321 13.395 −17.258 1.00 20.06 B C ATOM 13526 CB GLU B 314 34.224 13.987 −18.154 1.00 20.50 B C ATOM 13529 CG GLU B 314 34.697 15.089 −19.102 1.00 21.76 B C ATOM 13532 CD GLU B 314 33.609 15.550 −20.064 1.00 23.96 B C ATOM 13533 OE1 GLU B 314 33.914 16.363 −20.962 1.00 23.97 B O ATOM 13534 OE2 GLU B 314 32.449 15.100 −19.929 1.00 25.34 B O ATOM 13535 C GLU B 314 34.667 12.709 −16.053 1.00 19.90 B C ATOM 13536 O GLU B 314 34.342 13.369 −15.068 1.00 20.36 B O ATOM 13538 N ARG B 315 34.463 11.398 −16.141 1.00 19.78 B N ATOM 13539 CA ARG B 315 33.863 10.626 −15.054 1.00 20.09 B C ATOM 13541 CB ARG B 315 33.116 9.420 −15.616 1.00 20.83 B C ATOM 13544 CG ARG B 315 31.940 9.789 −16.488 1.00 23.42 B C ATOM 13547 CD ARG B 315 31.282 8.560 −17.080 1.00 27.26 B C ATOM 13550 NE ARG B 315 30.102 8.922 −17.863 1.00 32.39 B N ATOM 13552 CZ ARG B 315 28.915 9.250 −17.351 1.00 35.04 B C ATOM 13553 NH1 ARG B 315 28.712 9.262 −16.035 1.00 36.54 B N ATOM 13556 NH2 ARG B 315 27.914 9.567 −18.168 1.00 34.69 B N ATOM 13559 C ARG B 315 34.901 10.145 −14.049 1.00 19.51 B C ATOM 13560 O ARG B 315 34.642 10.126 −12.845 1.00 19.73 B O ATOM 13562 N TRP B 316 36.065 9.741 −14.553 1.00 18.77 B N ATOM 13563 CA TRP B 316 37.150 9.218 −13.725 1.00 17.72 B C ATOM 13565 CB TRP B 316 37.694 10.308 −12.794 1.00 17.03 B C ATOM 13568 CG TRP B 316 39.112 10.081 −12.398 1.00 14.29 B C ATOM 13569 CD1 TRP B 316 39.566 9.639 −11.195 1.00 13.02 B C ATOM 13571 NE1 TRP B 316 40.934 9.547 −11.211 1.00 12.01 B N ATOM 13573 CE2 TRP B 316 41.389 9.930 −12.443 1.00 11.63 B C ATOM 13574 CD2 TRP B 316 40.267 10.271 −13.218 1.00 12.10 B C ATOM 13575 CE3 TRP B 316 40.462 10.702 −14.533 1.00 13.74 B C ATOM 13577 CZ3 TRP B 316 41.752 10.778 −15.024 1.00 13.08 B C ATOM 13579 CH2 TRP B 316 42.848 10.432 −14.228 1.00 13.51 B C ATOM 13581 CZ2 TRP B 316 42.688 10.004 −12.937 1.00 13.12 B C ATOM 13583 C TRP B 316 36.678 7.995 −12.940 1.00 17.90 B C ATOM 13584 O TRP B 316 36.859 7.909 −11.727 1.00 17.86 B O ATOM 13586 N ASP B 317 36.073 7.053 −13.658 1.00 18.19 B N ATOM 13587 CA ASP B 317 35.487 5.863 −13.057 1.00 18.63 B C ATOM 13589 CB ASP B 317 33.983 5.825 −13.354 1.00 18.49 B C ATOM 13592 CG ASP B 317 33.270 4.671 −12.664 1.00 18.45 B C ATOM 13593 OD1 ASP B 317 33.789 4.140 −11.659 1.00 17.90 B O ATOM 13594 OD2 ASP B 317 32.173 4.298 −13.129 1.00 19.26 B O ATOM 13595 C ASP B 317 36.177 4.618 −13.605 1.00 19.33 B C ATOM 13596 O ASP B 317 35.899 4.186 −14.723 1.00 19.83 B O ATOM 13598 N VAL B 318 37.072 4.040 −12.808 1.00 20.11 B N ATOM 13599 CA VAL B 318 37.836 2.857 −13.222 1.00 20.65 B C ATOM 13601 CB VAL B 318 38.983 2.555 −12.231 1.00 20.75 B C ATOM 13603 CG1 VAL B 318 40.006 1.618 −12.859 1.00 20.37 B C ATOM 13607 CG2 VAL B 318 38.434 1.984 −10.929 1.00 21.89 B C ATOM 13611 C VAL B 318 36.973 1.601 −13.381 1.00 21.11 B C ATOM 13612 O VAL B 318 37.433 0.607 −13.938 1.00 21.49 B O ATOM 13614 N ASN B 319 35.739 1.640 −12.879 1.00 21.87 B N ATOM 13615 CA ASN B 319 34.769 0.561 −13.103 1.00 22.19 B C ATOM 13617 CB ASN B 319 33.661 0.605 −12.049 1.00 22.01 B C ATOM 13620 CG ASN B 319 34.184 0.354 −10.645 1.00 23.10 B C ATOM 13621 OD1 ASN B 319 34.633 −0.747 −10.323 1.00 24.06 B O ATOM 13622 ND2 ASN B 319 34.126 1.379 −9.801 1.00 22.91 B N ATOM 13625 C ASN B 319 34.157 0.624 −14.503 1.00 22.52 B C ATOM 13626 O ASN B 319 33.797 −0.407 −15.071 1.00 22.62 B O ATOM 13628 N ALA B 320 34.057 1.833 −15.057 1.00 22.93 B N ATOM 13629 CA ALA B 320 33.528 2.040 −16.411 1.00 23.46 B C ATOM 13631 CB ALA B 320 32.801 3.381 −16.485 1.00 23.82 B C ATOM 13635 C ALA B 320 34.615 1.966 −17.495 1.00 23.78 B C ATOM 13636 O ALA B 320 34.456 2.528 −18.579 1.00 23.85 B O ATOM 13638 N ILE B 321 35.714 1.275 −17.197 1.00 24.14 B N ATOM 13639 CA ILE B 321 36.796 1.063 −18.159 1.00 23.92 B C ATOM 13641 CB ILE B 321 38.086 0.529 −17.457 1.00 24.05 B C ATOM 13643 CG1 ILE B 321 39.279 0.540 −18.416 1.00 23.88 B C ATOM 13646 CD1 ILE B 321 40.563 0.038 −17.785 1.00 24.06 B C ATOM 13650 CG2 ILE B 321 37.873 −0.878 −16.884 1.00 23.28 B C ATOM 13654 C ILE B 321 36.356 0.103 −19.267 1.00 23.68 B C ATOM 13655 O ILE B 321 36.578 0.379 −20.445 1.00 23.41 B O ATOM 13657 N ASN B 322 35.706 −0.999 −18.882 1.00 23.66 B N ATOM 13658 CA ASN B 322 35.280 −2.050 −19.823 1.00 23.61 B C ATOM 13660 CB ASN B 322 34.503 −3.165 −19.093 1.00 23.73 B C ATOM 13663 CG ASN B 322 35.413 −4.227 −18.468 1.00 23.75 B C ATOM 13664 OD1 ASN B 322 36.561 −4.414 −18.877 1.00 23.33 B O ATOM 13665 ND2 ASN B 322 34.885 −4.939 −17.479 1.00 22.49 B N ATOM 13668 C ASN B 322 34.434 −1.539 −20.992 1.00 23.44 B C ATOM 13669 O ASN B 322 34.330 −2.207 −22.021 1.00 23.62 B O ATOM 13671 N ASP B 323 33.828 −0.365 −20.826 1.00 23.09 B N ATOM 13672 CA ASP B 323 33.050 0.269 −21.889 1.00 22.51 B C ATOM 13674 CB ASP B 323 32.249 1.458 −21.328 1.00 23.08 B C ATOM 13677 CG ASP B 323 31.293 1.056 −20.201 1.00 23.77 B C ATOM 13678 OD1 ASP B 323 30.528 0.081 −20.377 1.00 23.68 B O ATOM 13679 OD2 ASP B 323 31.302 1.725 −19.143 1.00 23.10 B O ATOM 13680 C ASP B 323 33.937 0.740 −23.051 1.00 21.15 B C ATOM 13681 O ASP B 323 33.467 0.856 −24.182 1.00 20.67 B O ATOM 13683 N LEU B 324 35.214 1.001 −22.767 1.00 20.28 B N ATOM 13684 CA LEU B 324 36.155 1.517 −23.766 1.00 19.81 B C ATOM 13686 CB LEU B 324 37.278 2.299 −23.075 1.00 19.75 B C ATOM 13689 CG LEU B 324 36.855 3.536 −22.280 1.00 19.79 B C ATOM 13691 CD1 LEU B 324 38.033 4.107 −21.504 1.00 18.72 B C ATOM 13695 CD2 LEU B 324 36.257 4.590 −23.200 1.00 19.38 B C ATOM 13699 C LEU B 324 36.775 0.408 −24.620 1.00 19.40 B C ATOM 13700 O LEU B 324 36.895 −0.731 −24.164 1.00 19.28 B O ATOM 13702 N PRO B 325 37.186 0.743 −25.860 1.00 18.93 B N ATOM 13703 CA PRO B 325 37.864 −0.226 −26.720 1.00 18.63 B C ATOM 13705 CB PRO B 325 37.910 0.480 −28.077 1.00 18.57 B C ATOM 13708 CG PRO B 325 37.894 1.915 −27.751 1.00 18.71 B C ATOM 13711 CD PRO B 325 37.036 2.048 −26.528 1.00 18.93 B C ATOM 13714 C PRO B 325 39.274 −0.545 −26.227 1.00 18.43 B C ATOM 13715 O PRO B 325 39.858 0.231 −25.468 1.00 17.77 B O ATOM 13716 N ASP B 326 39.808 −1.676 −26.678 1.00 18.61 B N ATOM 13717 CA ASP B 326 41.035 −2.248 −26.113 1.00 18.76 B C ATOM 13719 CB ASP B 326 41.455 −3.501 −26.894 1.00 19.31 B C ATOM 13722 CG ASP B 326 40.570 −4.708 −26.599 1.00 20.22 B C ATOM 13723 OD1 ASP B 326 39.894 −4.730 −25.545 1.00 21.20 B O ATOM 13724 OD2 ASP B 326 40.565 −5.649 −27.422 1.00 21.66 B O ATOM 13725 C ASP B 326 42.211 −1.277 −26.015 1.00 18.24 B C ATOM 13726 O ASP B 326 42.806 −1.145 −24.948 1.00 18.18 B O ATOM 13728 N TYR B 327 42.547 −0.599 −27.109 1.00 17.94 B N ATOM 13729 CA TYR B 327 43.695 0.316 −27.094 1.00 17.68 B C ATOM 13731 CB TYR B 327 44.061 0.800 −28.506 1.00 17.63 B C ATOM 13734 CG TYR B 327 43.152 1.858 −29.101 1.00 17.30 B C ATOM 13735 CD1 TYR B 327 41.980 1.506 −29.768 1.00 17.77 B C ATOM 13737 CE1 TYR B 327 41.151 2.475 −30.328 1.00 17.15 B C ATOM 13739 CZ TYR B 327 41.497 3.811 −30.233 1.00 17.82 B C ATOM 13740 OH TYR B 327 40.684 4.774 −30.783 1.00 19.10 B O ATOM 13742 CE2 TYR B 327 42.659 4.185 −29.584 1.00 17.85 B C ATOM 13744 CD2 TYR B 327 43.482 3.208 −29.027 1.00 17.88 B C ATOM 13746 C TYR B 327 43.474 1.497 −26.149 1.00 17.55 B C ATOM 13747 O TYR B 327 44.435 2.025 −25.587 1.00 17.97 B O ATOM 13749 N MET B 328 42.215 1.894 −25.966 1.00 17.24 B N ATOM 13750 CA MET B 328 41.866 2.972 −25.033 1.00 16.88 B C ATOM 13752 CB MET B 328 40.511 3.582 −25.390 1.00 16.72 B C ATOM 13755 CG MET B 328 40.549 4.380 −26.674 1.00 16.24 B C ATOM 13758 SD MET B 328 39.002 5.199 −27.066 1.00 13.82 B S ATOM 13759 CE MET B 328 39.582 6.357 −28.303 1.00 13.73 B C ATOM 13763 C MET B 328 41.865 2.507 −23.578 1.00 16.65 B C ATOM 13764 O MET B 328 42.227 3.274 −22.688 1.00 16.22 B O ATOM 13766 N LYS B 329 41.449 1.262 −23.342 1.00 16.55 B N ATOM 13767 CA LYS B 329 41.524 0.661 −22.008 1.00 16.67 B C ATOM 13769 CB LYS B 329 41.107 −0.813 −22.045 1.00 17.17 B C ATOM 13772 CG LYS B 329 39.614 −1.076 −22.199 1.00 19.24 B C ATOM 13775 CD LYS B 329 39.370 −2.516 −22.662 1.00 21.98 B C ATOM 13778 CE LYS B 329 38.095 −3.116 −22.093 1.00 23.19 B C ATOM 13781 NZ LYS B 329 37.911 −4.532 −22.538 1.00 24.02 B N ATOM 13785 C LYS B 329 42.946 0.754 −21.469 1.00 16.07 B C ATOM 13786 O LYS B 329 43.177 1.281 −20.381 1.00 16.02 B O ATOM 13788 N LEU B 330 43.891 0.238 −22.248 1.00 15.71 B N ATOM 13789 CA LEU B 330 45.300 0.211 −21.859 1.00 15.48 B C ATOM 13791 CB LEU B 330 46.118 −0.574 −22.889 1.00 15.59 B C ATOM 13794 CG LEU B 330 47.578 −0.875 −22.540 1.00 15.37 B C ATOM 13796 CD1 LEU B 330 47.655 −1.862 −21.387 1.00 15.91 B C ATOM 13800 CD2 LEU B 330 48.314 −1.411 −23.758 1.00 14.02 B C ATOM 13804 C LEU B 330 45.868 1.622 −21.710 1.00 15.18 B C ATOM 13805 O LEU B 330 46.670 1.876 −20.812 1.00 15.28 B O ATOM 13807 N CYS B 331 45.453 2.529 −22.592 1.00 14.49 B N ATOM 13808 CA CYS B 331 45.875 3.929 −22.525 1.00 13.98 B C ATOM 13810 CB CYS B 331 45.494 4.665 −23.814 1.00 14.01 B C ATOM 13813 SG CYS B 331 45.852 6.448 −23.790 1.00 16.06 B S ATOM 13815 C CYS B 331 45.265 4.652 −21.321 1.00 13.11 B C ATOM 13816 O CYS B 331 45.969 5.344 −20.581 1.00 12.31 B O ATOM 13818 N PHE B 332 43.956 4.485 −21.137 1.00 12.49 B N ATOM 13819 CA PHE B 332 43.220 5.171 −20.074 1.00 12.12 B C ATOM 13821 CB PHE B 332 41.712 4.935 −20.229 1.00 11.94 B C ATOM 13824 CG PHE B 332 40.889 5.500 −19.105 1.00 11.71 B C ATOM 13825 CD1 PHE B 332 40.586 6.852 −19.062 1.00 11.58 B C ATOM 13827 CE1 PHE B 332 39.831 7.379 −18.023 1.00 12.01 B C ATOM 13829 CZ PHE B 332 39.369 6.550 −17.013 1.00 11.84 B C ATOM 13831 CE2 PHE B 332 39.665 5.199 −17.044 1.00 12.39 B C ATOM 13833 CD2 PHE B 332 40.423 4.680 −18.087 1.00 12.36 B C ATOM 13835 C PHE B 332 43.673 4.745 −18.674 1.00 12.03 B C ATOM 13836 O PHE B 332 43.919 5.593 −17.812 1.00 11.73 B O ATOM 13838 N LEU B 333 43.778 3.435 −18.455 1.00 11.78 B N ATOM 13839 CA LEU B 333 44.160 2.893 −17.144 1.00 11.25 B C ATOM 13841 CB LEU B 333 43.998 1.365 −17.122 1.00 10.70 B C ATOM 13844 CG LEU B 333 44.058 0.648 −15.767 1.00 8.41 B C ATOM 13846 CD1 LEU B 333 43.018 1.170 −14.793 1.00 5.66 B C ATOM 13850 CD2 LEU B 333 43.874 −0.840 −15.966 1.00 6.27 B C ATOM 13854 C LEU B 333 45.588 3.282 −16.761 1.00 11.55 B C ATOM 13855 O LEU B 333 45.898 3.420 −15.577 1.00 11.81 B O ATOM 13857 N ALA B 334 46.449 3.462 −17.762 1.00 11.79 B N ATOM 13858 CA ALA B 334 47.815 3.935 −17.539 1.00 11.84 B C ATOM 13860 CB ALA B 334 48.625 3.847 −18.825 1.00 11.68 B C ATOM 13864 C ALA B 334 47.809 5.369 −17.013 1.00 12.02 B C ATOM 13865 O ALA B 334 48.401 5.660 −15.975 1.00 11.95 B O ATOM 13867 N LEU B 335 47.135 6.258 −17.736 1.00 12.45 B N ATOM 13868 CA LEU B 335 46.991 7.648 −17.311 1.00 12.66 B C ATOM 13870 CB LEU B 335 46.194 8.447 −18.352 1.00 12.71 B C ATOM 13873 CG LEU B 335 46.041 9.954 −18.117 1.00 12.97 B C ATOM 13875 CD1 LEU B 335 47.397 10.642 −18.055 1.00 13.00 B C ATOM 13879 CD2 LEU B 335 45.178 10.572 −19.202 1.00 11.60 B C ATOM 13883 C LEU B 335 46.299 7.714 −15.950 1.00 12.72 B C ATOM 13884 O LEU B 335 46.785 8.372 −15.035 1.00 12.67 B O ATOM 13886 N TYR B 336 45.176 7.013 −15.826 1.00 13.04 B N ATOM 13887 CA TYR B 336 44.394 6.979 −14.584 1.00 13.37 B C ATOM 13889 CB TYR B 336 43.346 5.865 −14.661 1.00 13.50 B C ATOM 13892 CG TYR B 336 42.316 5.877 −13.556 1.00 13.69 B C ATOM 13893 CD1 TYR B 336 41.167 6.654 −13.662 1.00 15.39 B C ATOM 13895 CE1 TYR B 336 40.205 6.659 −12.659 1.00 15.19 B C ATOM 13897 CZ TYR B 336 40.386 5.879 −11.536 1.00 13.61 B C ATOM 13898 OH TYR B 336 39.433 5.885 −10.545 1.00 12.30 B O ATOM 13900 CE2 TYR B 336 41.517 5.091 −11.410 1.00 13.99 B C ATOM 13902 CD2 TYR B 336 42.472 5.091 −12.420 1.00 13.11 B C ATOM 13904 C TYR B 336 45.276 6.778 −13.351 1.00 13.42 B C ATOM 13905 O TYR B 336 45.282 7.612 −12.446 1.00 13.88 B O ATOM 13907 N ASN B 337 46.026 5.678 −13.336 1.00 13.13 B N ATOM 13908 CA ASN B 337 46.914 5.349 −12.221 1.00 12.80 B C ATOM 13910 CB ASN B 337 47.573 3.985 −12.443 1.00 12.62 B C ATOM 13913 CG ASN B 337 46.576 2.842 −12.446 1.00 12.42 B C ATOM 13914 OD1 ASN B 337 45.386 3.036 −12.200 1.00 11.43 B O ATOM 13915 ND2 ASN B 337 47.062 1.639 −12.726 1.00 12.41 B N ATOM 13918 C ASN B 337 47.997 6.404 −12.020 1.00 13.00 B C ATOM 13919 O ASN B 337 48.274 6.810 −10.891 1.00 13.85 B O ATOM 13921 N THR B 338 48.606 6.838 −13.120 1.00 12.67 B N ATOM 13922 CA THR B 338 49.656 7.852 −13.079 1.00 12.12 B C ATOM 13924 CB THR B 338 50.137 8.222 −14.498 1.00 11.99 B C ATOM 13926 OG1 THR B 338 50.664 7.057 −15.145 1.00 9.18 B O ATOM 13928 CG2 THR B 338 51.207 9.303 −14.444 1.00 11.84 B C ATOM 13932 C THR B 338 49.161 9.111 −12.384 1.00 12.48 B C ATOM 13933 O THR B 338 49.859 9.671 −11.540 1.00 12.39 B O ATOM 13935 N ILE B 339 47.950 9.540 −12.734 1.00 13.07 B N ATOM 13936 CA ILE B 339 47.373 10.759 −12.172 1.00 13.52 B C ATOM 13938 CB ILE B 339 46.123 11.241 −12.956 1.00 13.22 B C ATOM 13940 CG1 ILE B 339 46.443 11.474 −14.438 1.00 12.90 B C ATOM 13943 CD1 ILE B 339 47.622 12.375 −14.683 1.00 11.77 B C ATOM 13947 CG2 ILE B 339 45.587 12.534 −12.362 1.00 12.97 B C ATOM 13951 C ILE B 339 47.018 10.561 −10.697 1.00 14.03 B C ATOM 13952 O ILE B 339 47.294 11.430 −9.870 1.00 15.15 B O ATOM 13954 N ASN B 340 46.419 9.422 −10.364 1.00 13.83 B N ATOM 13955 CA ASN B 340 46.116 9.116 −8.967 1.00 13.79 B C ATOM 13957 CB ASN B 340 45.287 7.837 −8.852 1.00 13.39 B C ATOM 13960 CG ASN B 340 43.876 8.015 −9.360 1.00 12.83 B C ATOM 13961 OD1 ASN B 340 43.552 9.024 −9.987 1.00 11.69 B O ATOM 13962 ND2 ASN B 340 43.024 7.035 −9.092 1.00 12.15 B N ATOM 13965 C ASN B 340 47.375 8.995 −8.115 1.00 14.39 B C ATOM 13966 O ASN B 340 47.356 9.331 −6.933 1.00 14.92 B O ATOM 13968 N GLU B 341 48.465 8.527 −8.720 1.00 14.80 B N ATOM 13969 CA GLU B 341 49.731 8.361 −8.006 1.00 15.19 B C ATOM 13971 CB GLU B 341 50.702 7.500 −8.819 1.00 15.65 B C ATOM 13974 CG GLU B 341 52.057 7.297 −8.150 1.00 17.64 B C ATOM 13977 CD GLU B 341 52.785 6.076 −8.668 1.00 21.06 B C ATOM 13978 OE1 GLU B 341 53.791 6.243 −9.394 1.00 22.18 B O ATOM 13979 OE2 GLU B 341 52.343 4.951 −8.353 1.00 23.01 B O ATOM 13980 C GLU B 341 50.376 9.704 −7.652 1.00 14.68 B C ATOM 13981 O GLU B 341 50.952 9.848 −6.573 1.00 14.72 B O ATOM 13983 N ILE B 342 50.288 10.679 −8.555 1.00 14.12 B N ATOM 13984 CA ILE B 342 50.753 12.035 −8.253 1.00 13.72 B C ATOM 13986 CB ILE B 342 50.765 12.945 −9.498 1.00 13.57 B C ATOM 13988 CG1 ILE B 342 51.775 12.434 −10.526 1.00 14.64 B C ATOM 13991 CD1 ILE B 342 51.843 13.277 −11.792 1.00 15.37 B C ATOM 13995 CG2 ILE B 342 51.123 14.376 −9.111 1.00 13.73 B C ATOM 13999 C ILE B 342 49.858 12.654 −7.179 1.00 13.24 B C ATOM 14000 O ILE B 342 50.340 13.359 −6.290 1.00 13.44 B O ATOM 14002 N ALA B 343 48.557 12.379 −7.270 1.00 12.34 B N ATOM 14003 CA ALA B 343 47.592 12.806 −6.261 1.00 11.40 B C ATOM 14005 CB ALA B 343 46.197 12.362 −6.654 1.00 11.24 B C ATOM 14009 C ALA B 343 47.956 12.253 −4.883 1.00 10.91 B C ATOM 14010 O ALA B 343 47.833 12.953 −3.876 1.00 10.88 B O ATOM 14012 N TYR B 344 48.409 11.001 −4.851 1.00 10.38 B N ATOM 14013 CA TYR B 344 48.833 10.355 −3.607 1.00 10.04 B C ATOM 14015 CB TYR B 344 49.023 8.845 −3.814 1.00 9.93 B C ATOM 14018 CG TYR B 344 49.475 8.118 −2.569 1.00 8.21 B C ATOM 14019 CD1 TYR B 344 48.553 7.639 −1.648 1.00 6.65 B C ATOM 14021 CE1 TYR B 344 48.963 6.982 −0.497 1.00 6.47 B C ATOM 14023 CZ TYR B 344 50.309 6.799 −0.254 1.00 6.00 B C ATOM 14024 OH TYR B 344 50.715 6.147 0.888 1.00 4.30 B O ATOM 14026 CE2 TYR B 344 51.247 7.268 −1.154 1.00 7.46 B C ATOM 14028 CD2 TYR B 344 50.827 7.924 −2.304 1.00 8.03 B C ATOM 14030 C TYR B 344 50.119 10.977 −3.064 1.00 10.06 B C ATOM 14031 O TYR B 344 50.269 11.142 −1.856 1.00 10.03 B O ATOM 14033 N ASP B 345 51.047 11.310 −3.957 1.00 10.36 B N ATOM 14034 CA ASP B 345 52.284 11.982 −3.559 1.00 10.78 B C ATOM 14036 CB ASP B 345 53.256 12.088 −4.740 1.00 10.82 B C ATOM 14039 CG ASP B 345 53.868 10.755 −5.123 1.00 10.93 B C ATOM 14040 OD1 ASP B 345 53.973 9.858 −4.256 1.00 11.03 B O ATOM 14041 OD2 ASP B 345 54.258 10.610 −6.300 1.00 12.06 B O ATOM 14042 C ASP B 345 52.011 13.377 −2.999 1.00 11.16 B C ATOM 14043 O ASP B 345 52.830 13.919 −2.259 1.00 11.52 B O ATOM 14045 N ASN B 346 50.873 13.959 −3.366 1.00 11.44 B N ATOM 14046 CA ASN B 346 50.468 15.260 −2.843 1.00 11.76 B C ATOM 14048 CB ASN B 346 49.615 16.005 −3.872 1.00 11.96 B C ATOM 14051 CG ASN B 346 50.458 16.711 −4.910 1.00 13.27 B C ATOM 14052 OD1 ASN B 346 51.086 17.729 −4.618 1.00 18.45 B O ATOM 14053 ND2 ASN B 346 50.485 16.174 −6.128 1.00 12.71 B N ATOM 14056 C ASN B 346 49.733 15.140 −1.514 1.00 11.65 B C ATOM 14057 O ASN B 346 49.944 15.953 −0.612 1.00 11.65 B O ATOM 14059 N LEU B 347 48.876 14.126 −1.399 1.00 11.52 B N ATOM 14060 CA LEU B 347 48.164 13.847 −0.150 1.00 11.25 B C ATOM 14062 CB LEU B 347 47.136 12.728 −0.350 1.00 10.95 B C ATOM 14065 CG LEU B 347 46.235 12.390 0.843 1.00 9.89 B C ATOM 14067 CD1 LEU B 347 45.291 13.541 1.145 1.00 9.37 B C ATOM 14071 CD2 LEU B 347 45.457 11.109 0.585 1.00 8.58 B C ATOM 14075 C LEU B 347 49.123 13.460 0.973 1.00 11.48 B C ATOM 14076 O LEU B 347 48.844 13.722 2.138 1.00 11.80 B O ATOM 14078 N LYS B 348 50.245 12.833 0.628 1.00 11.67 B N ATOM 14079 CA LYS B 348 51.230 12.424 1.627 1.00 11.74 B C ATOM 14081 CB LYS B 348 52.176 11.361 1.053 1.00 11.69 B C ATOM 14084 CG LYS B 348 53.032 10.658 2.104 1.00 10.78 B C ATOM 14087 CD LYS B 348 53.948 9.598 1.497 1.00 9.66 B C ATOM 14090 CE LYS B 348 55.189 10.191 0.836 1.00 8.44 B C ATOM 14093 NZ LYS B 348 54.959 10.572 −0.583 1.00 7.87 B N ATOM 14097 C LYS B 348 52.033 13.625 2.125 1.00 11.88 B C ATOM 14098 O LYS B 348 52.147 13.851 3.330 1.00 11.65 B O ATOM 14100 N ASP B 349 52.574 14.398 1.192 1.00 12.38 B N ATOM 14101 CA ASP B 349 53.508 15.469 1.532 1.00 13.33 B C ATOM 14103 CB ASP B 349 54.425 15.775 0.342 1.00 13.19 B C ATOM 14106 CG ASP B 349 55.170 14.546 −0.155 1.00 11.88 B C ATOM 14107 OD1 ASP B 349 55.312 13.572 0.616 1.00 7.56 B O ATOM 14108 OD2 ASP B 349 55.610 14.556 −1.324 1.00 11.49 B O ATOM 14109 C ASP B 349 52.808 16.745 1.996 1.00 14.12 B C ATOM 14110 O ASP B 349 53.261 17.387 2.944 1.00 14.75 B O ATOM 14112 N LYS B 350 51.711 17.107 1.335 1.00 14.58 B N ATOM 14113 CA LYS B 350 51.003 18.357 1.634 1.00 15.29 B C ATOM 14115 CB LYS B 350 50.751 19.137 0.339 1.00 15.87 B C ATOM 14118 CG LYS B 350 52.035 19.487 −0.411 1.00 18.40 B C ATOM 14121 CD LYS B 350 51.775 20.337 −1.651 1.00 20.21 B C ATOM 14124 CE LYS B 350 52.936 20.246 −2.646 1.00 20.06 B C ATOM 14127 NZ LYS B 350 54.271 20.455 −2.007 1.00 19.09 B N ATOM 14131 C LYS B 350 49.691 18.156 2.407 1.00 14.89 B C ATOM 14132 O LYS B 350 49.227 19.073 3.088 1.00 14.72 B O ATOM 14134 N GLY B 351 49.098 16.970 2.304 1.00 14.61 B N ATOM 14135 CA GLY B 351 47.889 16.645 3.060 1.00 14.57 B C ATOM 14138 C GLY B 351 46.615 17.209 2.463 1.00 14.52 B C ATOM 14139 O GLY B 351 45.688 17.560 3.193 1.00 14.37 B O ATOM 14141 N GLU B 352 46.568 17.286 1.134 1.00 14.82 B N ATOM 14142 CA GLU B 352 45.429 17.859 0.416 1.00 15.23 B C ATOM 14144 CB GLU B 352 45.789 19.240 −0.144 1.00 15.22 B C ATOM 14147 CG GLU B 352 46.260 20.271 0.894 1.00 15.93 B C ATOM 14150 CD GLU B 352 45.126 21.048 1.543 1.00 16.01 B C ATOM 14151 OE1 GLU B 352 43.998 20.519 1.642 1.00 17.82 B O ATOM 14152 OE2 GLU B 352 45.372 22.198 1.962 1.00 15.28 B O ATOM 14153 C GLU B 352 45.033 16.946 −0.738 1.00 15.54 B C ATOM 14154 O GLU B 352 45.897 16.437 −1.456 1.00 15.74 B O ATOM 14156 N ASN B 353 43.730 16.738 −0.914 1.00 15.72 B N ATOM 14157 CA ASN B 353 43.228 15.980 −2.058 1.00 15.71 B C ATOM 14159 CB ASN B 353 41.856 15.361 −1.762 1.00 15.94 B C ATOM 14162 CG ASN B 353 41.403 14.388 −2.847 1.00 16.62 B C ATOM 14163 OD1 ASN B 353 41.769 14.521 −4.016 1.00 16.74 B O ATOM 14164 ND2 ASN B 353 40.602 13.403 −2.459 1.00 17.81 B N ATOM 14167 C ASN B 353 43.148 16.888 −3.277 1.00 15.38 B C ATOM 14168 O ASN B 353 42.204 17.666 −3.424 1.00 15.14 B O ATOM 14170 N ILE B 354 44.145 16.775 −4.149 1.00 15.29 B N ATOM 14171 CA ILE B 354 44.202 17.576 −5.369 1.00 15.35 B C ATOM 14173 CB ILE B 354 45.608 18.197 −5.558 1.00 15.18 B C ATOM 14175 CG1 ILE B 354 46.670 17.121 −5.797 1.00 14.74 B C ATOM 14178 CD1 ILE B 354 47.872 17.644 −6.528 1.00 14.74 B C ATOM 14182 CG2 ILE B 354 45.982 19.020 −4.343 1.00 15.14 B C ATOM 14186 C ILE B 354 43.801 16.778 −6.623 1.00 15.64 B C ATOM 14187 O ILE B 354 44.136 17.163 −7.743 1.00 15.61 B O ATOM 14189 N LEU B 355 43.077 15.676 −6.437 1.00 15.92 B N ATOM 14190 CA LEU B 355 42.667 14.836 −7.564 1.00 15.93 B C ATOM 14192 CB LEU B 355 42.060 13.514 −7.073 1.00 15.64 B C ATOM 14195 CG LEU B 355 41.802 12.439 −8.136 1.00 14.69 B C ATOM 14197 CD1 LEU B 355 43.070 12.105 −8.906 1.00 13.49 B C ATOM 14201 CD2 LEU B 355 41.222 11.184 −7.499 1.00 14.54 B C ATOM 14205 C LEU B 355 41.698 15.550 −8.517 1.00 16.22 B C ATOM 14206 O LEU B 355 41.836 15.418 −9.735 1.00 16.22 B O ATOM 14208 N PRO B 356 40.724 16.311 −7.975 1.00 16.49 B N ATOM 14209 CA PRO B 356 39.781 16.987 −8.869 1.00 16.94 B C ATOM 14211 CB PRO B 356 38.843 17.727 −7.906 1.00 16.89 B C ATOM 14214 CG PRO B 356 38.992 17.035 −6.615 1.00 16.92 B C ATOM 14217 CD PRO B 356 40.410 16.581 −6.562 1.00 16.28 B C ATOM 14220 C PRO B 356 40.460 17.974 −9.817 1.00 17.52 B C ATOM 14221 O PRO B 356 40.087 18.046 −10.987 1.00 18.27 B O ATOM 14222 N TYR B 357 41.452 18.712 −9.318 1.00 17.33 B N ATOM 14223 CA TYR B 357 42.179 19.690 −10.138 1.00 17.07 B C ATOM 14225 CB TYR B 357 43.048 20.621 −9.276 1.00 16.94 B C ATOM 14228 CG TYR B 357 42.411 21.040 −7.969 1.00 17.63 B C ATOM 14229 CD1 TYR B 357 41.167 21.663 −7.945 1.00 19.45 B C ATOM 14231 CE1 TYR B 357 40.575 22.042 −6.742 1.00 19.39 B C ATOM 14233 CZ TYR B 357 41.234 21.798 −5.551 1.00 18.35 B C ATOM 14234 OH TYR B 357 40.661 22.171 −4.360 1.00 19.17 B O ATOM 14236 CE2 TYR B 357 42.470 21.183 −5.550 1.00 17.99 B C ATOM 14238 CD2 TYR B 357 43.051 20.807 −6.755 1.00 18.02 B C ATOM 14240 C TYR B 357 43.052 18.987 −11.180 1.00 16.70 B C ATOM 14241 O TYR B 357 43.176 19.463 −12.308 1.00 17.02 B O ATOM 14243 N LEU B 358 43.649 17.858 −10.797 1.00 16.01 B N ATOM 14244 CA LEU B 358 44.510 17.088 −11.699 1.00 15.44 B C ATOM 14246 CB LEU B 358 45.321 16.046 −10.922 1.00 15.39 B C ATOM 14249 CG LEU B 358 46.418 16.579 −9.998 1.00 15.39 B C ATOM 14251 CD1 LEU B 358 46.969 15.455 −9.137 1.00 16.30 B C ATOM 14255 CD2 LEU B 358 47.531 17.241 −10.791 1.00 15.02 B C ATOM 14259 C LEU B 358 43.720 16.397 −12.810 1.00 15.07 B C ATOM 14260 O LEU B 358 44.217 16.259 −13.928 1.00 14.92 B O ATOM 14262 N THR B 359 42.502 15.956 −12.501 1.00 14.50 B N ATOM 14263 CA THR B 359 41.643 15.320 −13.501 1.00 14.14 B C ATOM 14265 CB THR B 359 40.620 14.372 −12.857 1.00 14.08 B C ATOM 14267 OG1 THR B 359 39.832 15.087 −11.896 1.00 13.76 B O ATOM 14269 CG2 THR B 359 41.334 13.219 −12.179 1.00 13.80 B C ATOM 14273 C THR B 359 40.904 16.350 −14.349 1.00 13.91 B C ATOM 14274 O THR B 359 40.619 16.097 −15.519 1.00 13.91 B O ATOM 14276 N LYS B 360 40.595 17.505 −13.761 1.00 13.68 B N ATOM 14277 CA LYS B 360 39.919 18.583 −14.487 1.00 13.73 B C ATOM 14279 CB LYS B 360 39.565 19.742 −13.541 1.00 14.11 B C ATOM 14282 CG LYS B 360 38.670 20.824 −14.147 1.00 15.76 B C ATOM 14285 CD LYS B 360 37.240 20.337 −14.337 1.00 17.92 B C ATOM 14288 CE LYS B 360 36.414 21.340 −15.130 1.00 19.80 B C ATOM 14291 NZ LYS B 360 35.031 20.844 −15.397 1.00 21.13 B N ATOM 14295 C LYS B 360 40.785 19.080 −15.646 1.00 13.04 B C ATOM 14296 O LYS B 360 40.277 19.341 −16.738 1.00 12.64 B O ATOM 14298 N ALA B 361 42.089 19.200 −15.400 1.00 12.50 B N ATOM 14299 CA ALA B 361 43.043 19.582 −16.436 1.00 12.11 B C ATOM 14301 CB ALA B 361 44.430 19.730 −15.850 1.00 11.80 B C ATOM 14305 C ALA B 361 43.056 18.556 −17.562 1.00 12.30 B C ATOM 14306 O ALA B 361 43.047 18.925 −18.738 1.00 12.61 B O ATOM 14308 N TRP B 362 43.066 17.274 −17.198 1.00 12.41 B N ATOM 14309 CA TRP B 362 43.062 16.187 −18.184 1.00 12.60 B C ATOM 14311 CB TRP B 362 43.484 14.860 −17.545 1.00 12.31 B C ATOM 14314 CG TRP B 362 44.957 14.676 −17.578 1.00 12.74 B C ATOM 14315 CD1 TRP B 362 45.823 14.737 −16.524 1.00 13.49 B C ATOM 14317 NE1 TRP B 362 47.110 14.535 −16.958 1.00 12.06 B N ATOM 14319 CE2 TRP B 362 47.093 14.347 −18.315 1.00 11.96 B C ATOM 14320 CD2 TRP B 362 45.751 14.432 −18.737 1.00 11.61 B C ATOM 14321 CE3 TRP B 362 45.459 14.278 −20.094 1.00 11.70 B C ATOM 14323 CZ3 TRP B 362 46.499 14.042 −20.975 1.00 12.47 B C ATOM 14325 CH2 TRP B 362 47.824 13.960 −20.525 1.00 12.99 B C ATOM 14327 CZ2 TRP B 362 48.140 14.110 −19.201 1.00 12.91 B C ATOM 14329 C TRP B 362 41.725 16.024 −18.904 1.00 13.17 B C ATOM 14330 O TRP B 362 41.682 15.459 −19.997 1.00 13.14 B O ATOM 14332 N ALA B 363 40.646 16.510 −18.289 1.00 13.48 B N ATOM 14333 CA ALA B 363 39.325 16.500 −18.915 1.00 13.34 B C ATOM 14335 CB ALA B 363 38.235 16.626 −17.862 1.00 13.16 B C ATOM 14339 C ALA B 363 39.214 17.625 −19.940 1.00 13.54 B C ATOM 14340 O ALA B 363 38.772 17.398 −21.066 1.00 13.89 B O ATOM 14342 N ASP B 364 39.626 18.831 −19.553 1.00 13.59 B N ATOM 14343 CA ASP B 364 39.577 19.995 −20.447 1.00 13.61 B C ATOM 14345 CB ASP B 364 39.922 21.277 −19.683 1.00 13.78 B C ATOM 14348 CG ASP B 364 38.894 21.626 −18.616 1.00 16.18 B C ATOM 14349 OD1 ASP B 364 38.028 20.775 −18.311 1.00 19.21 B O ATOM 14350 OD2 ASP B 364 38.957 22.753 −18.077 1.00 17.35 B O ATOM 14351 C ASP B 364 40.503 19.861 −21.666 1.00 13.27 B C ATOM 14352 O ASP B 364 40.219 20.435 −22.721 1.00 12.94 B O ATOM 14354 N LEU B 365 41.601 19.116 −21.521 1.00 12.55 B N ATOM 14355 CA LEU B 365 42.537 18.901 −22.627 1.00 11.93 B C ATOM 14357 CB LEU B 365 43.893 18.407 −22.108 1.00 11.48 B C ATOM 14360 CG LEU B 365 44.991 18.096 −23.139 1.00 9.74 B C ATOM 14362 CD1 LEU B 365 45.213 19.237 −24.114 1.00 7.44 B C ATOM 14366 CD2 LEU B 365 46.293 17.754 −22.438 1.00 7.19 B C ATOM 14370 C LEU B 365 41.968 17.917 −23.643 1.00 12.31 B C ATOM 14371 O LEU B 365 42.123 18.103 −24.848 1.00 12.10 B O ATOM 14373 N CYS B 366 41.312 16.870 −23.156 1.00 13.31 B N ATOM 14374 CA CYS B 366 40.674 15.889 −24.034 1.00 14.41 B C ATOM 14376 CB CYS B 366 40.246 14.655 −23.240 1.00 14.50 B C ATOM 14379 SG CYS B 366 41.629 13.759 −22.500 1.00 14.66 B S ATOM 14381 C CYS B 366 39.475 16.505 −24.756 1.00 15.14 B C ATOM 14382 O CYS B 366 39.314 16.319 −25.966 1.00 15.49 B O ATOM 14384 N ASN B 367 38.641 17.229 −24.005 1.00 15.16 B N ATOM 14385 CA ASN B 367 37.579 18.057 −24.585 1.00 14.89 B C ATOM 14387 CB ASN B 367 36.875 18.893 −23.502 1.00 14.96 B C ATOM 14390 CG ASN B 367 35.727 18.155 −22.831 1.00 14.43 B C ATOM 14391 OD1 ASN B 367 34.815 17.660 −23.495 1.00 13.51 B O ATOM 14392 ND2 ASN B 367 35.751 18.110 −21.503 1.00 13.11 B N ATOM 14395 C ASN B 367 38.139 19.000 −25.648 1.00 15.02 B C ATOM 14396 O ASN B 367 37.520 19.203 −26.691 1.00 14.98 B O ATOM 14398 N ALA B 368 39.309 19.574 −25.368 1.00 15.27 B N ATOM 14399 CA ALA B 368 39.981 20.480 −26.303 1.00 15.42 B C ATOM 14401 CB ALA B 368 41.197 21.126 −25.646 1.00 15.49 B C ATOM 14405 C ALA B 368 40.394 19.763 −27.583 1.00 15.38 B C ATOM 14406 O ALA B 368 40.305 20.335 −28.672 1.00 14.84 B O ATOM 14408 N PHE B 369 40.850 18.517 −27.444 1.00 15.74 B N ATOM 14409 CA PHE B 369 41.198 17.689 −28.600 1.00 15.84 B C ATOM 14411 CB PHE B 369 41.926 16.405 −28.175 1.00 15.87 B C ATOM 14414 CG PHE B 369 43.362 16.608 −27.751 1.00 16.19 B C ATOM 14415 CD1 PHE B 369 44.261 17.284 −28.565 1.00 17.44 B C ATOM 14417 CE1 PHE B 369 45.589 17.449 −28.175 1.00 17.59 B C ATOM 14419 CZ PHE B 369 46.031 16.919 −26.978 1.00 14.90 B C ATOM 14421 CE2 PHE B 369 45.152 16.230 −26.169 1.00 14.93 B C ATOM 14423 CD2 PHE B 369 43.828 16.069 −26.558 1.00 16.05 B C ATOM 14425 C PHE B 369 39.953 17.313 −29.402 1.00 15.56 B C ATOM 14426 O PHE B 369 39.951 17.391 −30.628 1.00 15.57 B O ATOM 14428 N LEU B 370 38.898 16.904 −28.705 1.00 15.73 B N ATOM 14429 CA LEU B 370 37.660 16.472 −29.358 1.00 16.24 B C ATOM 14431 CB LEU B 370 36.587 16.157 −28.302 1.00 16.24 B C ATOM 14434 CG LEU B 370 35.468 15.179 −28.670 1.00 15.94 B C ATOM 14436 CD1 LEU B 370 36.027 13.860 −29.180 1.00 15.36 B C ATOM 14440 CD2 LEU B 370 34.569 14.943 −27.466 1.00 15.13 B C ATOM 14444 C LEU B 370 37.167 17.547 −30.328 1.00 16.58 B C ATOM 14445 O LEU B 370 36.894 17.269 −31.496 1.00 16.08 B O ATOM 14447 N GLN B 371 37.087 18.776 −29.828 1.00 17.63 B N ATOM 14448 CA GLN B 371 36.713 19.947 −30.624 1.00 18.39 B C ATOM 14450 CB GLN B 371 36.835 21.212 −29.761 1.00 18.47 B C ATOM 14453 CG GLN B 371 36.465 22.509 −30.455 1.00 18.40 B C ATOM 14456 CD GLN B 371 35.014 22.546 −30.854 1.00 19.71 B C ATOM 14457 OE1 GLN B 371 34.657 22.160 −31.965 1.00 21.51 B O ATOM 14458 NE2 GLN B 371 34.161 22.995 −29.942 1.00 21.78 B N ATOM 14461 C GLN B 371 37.557 20.098 −31.899 1.00 19.05 B C ATOM 14462 O GLN B 371 37.033 20.494 −32.943 1.00 19.37 B O ATOM 14464 N GLU B 372 38.857 19.803 −31.804 1.00 19.25 B N ATOM 14465 CA GLU B 372 39.748 19.811 −32.974 1.00 19.20 B C ATOM 14467 CB GLU B 372 41.226 19.689 −32.562 1.00 19.45 B C ATOM 14470 CG GLU B 372 41.877 20.997 −32.107 1.00 21.69 B C ATOM 14473 CD GLU B 372 43.356 20.840 −31.747 1.00 24.43 B C ATOM 14474 OE1 GLU B 372 43.861 19.695 −31.711 1.00 25.03 B O ATOM 14475 OE2 GLU B 372 44.017 21.870 −31.498 1.00 25.72 B O ATOM 14476 C GLU B 372 39.391 18.682 −33.941 1.00 18.59 B C ATOM 14477 O GLU B 372 39.372 18.883 −35.158 1.00 18.34 B O ATOM 14479 N ALA B 373 39.108 17.502 −33.391 1.00 18.19 B N ATOM 14480 CA ALA B 373 38.762 16.331 −34.195 1.00 17.99 B C ATOM 14482 CB ALA B 373 38.816 15.070 −33.345 1.00 17.85 B C ATOM 14486 C ALA B 373 37.386 16.472 −34.844 1.00 17.94 B C ATOM 14487 O ALA B 373 37.146 15.920 −35.916 1.00 18.34 B O ATOM 14489 N LYS B 374 36.486 17.205 −34.193 1.00 17.70 B N ATOM 14490 CA LYS B 374 35.146 17.438 −34.736 1.00 17.42 B C ATOM 14492 CB LYS B 374 34.195 17.945 −33.647 1.00 17.54 B C ATOM 14495 CG LYS B 374 33.700 16.869 −32.696 1.00 16.57 B C ATOM 14498 CD LYS B 374 32.755 17.459 −31.667 1.00 16.38 B C ATOM 14501 CE LYS B 374 32.149 16.392 −30.780 1.00 16.46 B C ATOM 14504 NZ LYS B 374 31.306 16.977 −29.704 1.00 15.25 B N ATOM 14508 C LYS B 374 35.174 18.425 −35.900 1.00 17.26 B C ATOM 14509 O LYS B 374 34.513 18.208 −36.915 1.00 17.43 B O ATOM 14511 N TRP B 375 35.934 19.509 −35.750 1.00 17.18 B N ATOM 14512 CA TRP B 375 36.105 20.483 −36.832 1.00 17.31 B C ATOM 14514 CB TRP B 375 36.949 21.681 −36.372 1.00 17.16 B C ATOM 14517 CG TRP B 375 36.259 22.614 −35.404 1.00 17.13 B C ATOM 14518 CD1 TRP B 375 34.916 22.857 −35.304 1.00 17.41 B C ATOM 14520 NE1 TRP B 375 34.674 23.782 −34.315 1.00 17.36 B N ATOM 14522 CE2 TRP B 375 35.868 24.171 −33.767 1.00 17.07 B C ATOM 14523 CD2 TRP B 375 36.891 23.458 −34.429 1.00 16.95 B C ATOM 14524 CE3 TRP B 375 38.221 23.677 −34.049 1.00 15.71 B C ATOM 14526 CZ3 TRP B 375 38.484 24.587 −33.029 1.00 15.41 B C ATOM 14528 CH2 TRP B 375 37.444 25.278 −32.389 1.00 16.22 B C ATOM 14530 CZ2 TRP B 375 36.133 25.084 −32.741 1.00 16.57 B C ATOM 14532 C TRP B 375 36.750 19.842 −38.066 1.00 17.41 B C ATOM 14533 O TRP B 375 36.502 20.269 −39.198 1.00 17.35 B O ATOM 14535 N LEU B 376 37.570 18.818 −37.840 1.00 17.35 B N ATOM 14536 CA LEU B 376 38.231 18.100 −38.923 1.00 17.23 B C ATOM 14538 CB LEU B 376 39.425 17.302 −38.391 1.00 17.49 B C ATOM 14541 CG LEU B 376 40.555 17.070 −39.395 1.00 18.22 B C ATOM 14543 CD1 LEU B 376 41.433 18.312 −39.485 1.00 19.63 B C ATOM 14547 CD2 LEU B 376 41.383 15.849 −39.012 1.00 19.32 B C ATOM 14551 C LEU B 376 37.248 17.167 −39.627 1.00 16.88 B C ATOM 14552 O LEU B 376 37.183 17.143 −40.854 1.00 17.11 B O ATOM 14554 N TYR B 377 36.486 16.402 −38.849 1.00 16.77 B N ATOM 14555 CA TYR B 377 35.499 15.476 −39.412 1.00 17.06 B C ATOM 14557 CB TYR B 377 34.930 14.547 −38.327 1.00 17.15 B C ATOM 14560 CG TYR B 377 33.854 13.587 −38.814 1.00 17.58 B C ATOM 14561 CD1 TYR B 377 34.187 12.403 −39.475 1.00 17.98 B C ATOM 14563 CE1 TYR B 377 33.200 11.520 −39.920 1.00 17.11 B C ATOM 14565 CZ TYR B 377 31.865 11.820 −39.701 1.00 17.79 B C ATOM 14566 OH TYR B 377 30.880 10.962 −40.133 1.00 15.15 B O ATOM 14568 CE2 TYR B 377 31.511 12.987 −39.047 1.00 19.01 B C ATOM 14570 CD2 TYR B 377 32.504 13.862 −38.608 1.00 18.51 B C ATOM 14572 C TYR B 377 34.365 16.223 −40.116 1.00 16.88 B C ATOM 14573 O TYR B 377 33.846 15.748 −41.126 1.00 17.51 B O ATOM 14575 N ASN B 378 33.996 17.390 −39.590 1.00 16.33 B N ATOM 14576 CA ASN B 378 32.891 18.178 −40.140 1.00 16.09 B C ATOM 14578 CB ASN B 378 32.095 18.824 −38.999 1.00 16.18 B C ATOM 14581 CG ASN B 378 31.487 17.797 −38.053 1.00 15.67 B C ATOM 14582 OD1 ASN B 378 30.872 16.821 −38.486 1.00 14.58 B O ATOM 14583 ND2 ASN B 378 31.651 18.021 −36.755 1.00 13.56 B N ATOM 14586 C ASN B 378 33.333 19.252 −41.141 1.00 15.94 B C ATOM 14587 O ASN B 378 32.503 20.019 −41.630 1.00 15.56 B O ATOM 14589 N LYS B 379 34.632 19.300 −41.444 1.00 16.13 B N ATOM 14590 CA LYS B 379 35.208 20.300 −42.358 1.00 16.30 B C ATOM 14592 CB LYS B 379 34.699 20.087 −43.797 1.00 16.31 B C ATOM 14595 CG LYS B 379 35.509 19.101 −44.626 1.00 17.12 B C ATOM 14598 CD LYS B 379 35.221 19.295 −46.113 1.00 18.17 B C ATOM 14601 CE LYS B 379 35.889 18.233 −46.973 1.00 20.00 B C ATOM 14604 NZ LYS B 379 35.188 16.917 −46.903 1.00 20.73 B N ATOM 14608 C LYS B 379 34.963 21.756 −41.922 1.00 16.29 B C ATOM 14609 O LYS B 379 34.987 22.669 −42.751 1.00 16.86 B O ATOM 14611 N SER B 380 34.755 21.978 −40.625 1.00 15.76 B N ATOM 14612 CA SER B 380 34.443 23.312 −40.119 1.00 15.29 B C ATOM 14614 CB SER B 380 34.179 23.266 −38.614 1.00 15.44 B C ATOM 14617 OG SER B 380 33.129 22.367 −38.305 1.00 15.59 B O ATOM 14619 C SER B 380 35.580 24.284 −40.417 1.00 14.99 B C ATOM 14620 O SER B 380 36.743 23.885 −40.479 1.00 14.56 B O ATOM 14622 N THR B 381 35.231 25.557 −40.600 1.00 14.97 B N ATOM 14623 CA THR B 381 36.196 26.607 −40.939 1.00 14.59 B C ATOM 14625 CB THR B 381 35.976 27.102 −42.383 1.00 14.34 B C ATOM 14627 OG1 THR B 381 34.623 27.544 −42.533 1.00 13.29 B O ATOM 14629 CG2 THR B 381 36.243 25.984 −43.376 1.00 14.48 B C ATOM 14633 C THR B 381 36.079 27.788 −39.969 1.00 14.43 B C ATOM 14634 O THR B 381 35.732 28.900 −40.379 1.00 14.36 B O ATOM 14636 N PRO B 382 36.379 27.551 −38.676 1.00 14.16 B N ATOM 14637 CA PRO B 382 36.183 28.563 −37.635 1.00 14.13 B C ATOM 14639 CB PRO B 382 36.455 27.790 −36.336 1.00 14.03 B C ATOM 14642 CG PRO B 382 37.313 26.672 −36.731 1.00 13.70 B C ATOM 14645 CD PRO B 382 36.876 26.285 −38.107 1.00 13.99 B C ATOM 14648 C PRO B 382 37.114 29.768 −37.731 1.00 13.68 B C ATOM 14649 O PRO B 382 38.166 29.702 −38.368 1.00 13.57 B O ATOM 14650 N THR B 383 36.709 30.857 −37.082 1.00 13.56 B N ATOM 14651 CA THR B 383 37.507 32.075 −37.022 1.00 13.70 B C ATOM 14653 CB THR B 383 36.758 33.208 −36.285 1.00 13.82 B C ATOM 14655 OG1 THR B 383 36.295 32.735 −35.013 1.00 13.66 B O ATOM 14657 CG2 THR B 383 35.571 33.691 −37.103 1.00 13.85 B C ATOM 14661 C THR B 383 38.809 31.809 −36.289 1.00 13.73 B C ATOM 14662 O THR B 383 38.962 30.774 −35.645 1.00 14.13 B O ATOM 14664 N PHE B 384 39.744 32.747 −36.387 1.00 13.93 B N ATOM 14665 CA PHE B 384 41.013 32.645 −35.668 1.00 13.87 B C ATOM 14667 CB PHE B 384 41.974 33.752 −36.117 1.00 13.82 B C ATOM 14670 CG PHE B 384 43.181 33.906 −35.237 1.00 14.42 B C ATOM 14671 CD1 PHE B 384 44.302 33.112 −35.428 1.00 15.39 B C ATOM 14673 CE1 PHE B 384 45.421 33.253 −34.613 1.00 15.72 B C ATOM 14675 CZ PHE B 384 45.423 34.201 −33.597 1.00 16.47 B C ATOM 14677 CE2 PHE B 384 44.307 35.002 −33.398 1.00 15.83 B C ATOM 14679 CD2 PHE B 384 43.195 34.851 −34.215 1.00 15.61 B C ATOM 14681 C PHE B 384 40.803 32.697 −34.155 1.00 13.83 B C ATOM 14682 O PHE B 384 41.562 32.086 −33.407 1.00 13.69 B O ATOM 14684 N ASP B 385 39.773 33.419 −33.714 1.00 14.28 B N ATOM 14685 CA ASP B 385 39.461 33.546 −32.286 1.00 14.69 B C ATOM 14687 CB ASP B 385 38.335 34.564 −32.067 1.00 14.68 B C ATOM 14690 CG ASP B 385 38.758 35.989 −32.377 1.00 14.29 B C ATOM 14691 OD1 ASP B 385 39.916 36.198 −32.801 1.00 12.29 B O ATOM 14692 OD2 ASP B 385 37.922 36.901 −32.194 1.00 13.65 B O ATOM 14693 C ASP B 385 39.072 32.212 −31.647 1.00 14.95 B C ATOM 14694 O ASP B 385 39.558 31.872 −30.565 1.00 15.03 B O ATOM 14696 N ASP B 386 38.199 31.463 −32.315 1.00 15.10 B N ATOM 14697 CA ASP B 386 37.756 30.164 −31.807 1.00 15.21 B C ATOM 14699 CB ASP B 386 36.562 29.635 −32.608 1.00 14.89 B C ATOM 14702 CG ASP B 386 35.352 30.537 −32.518 1.00 13.79 B C ATOM 14703 OD1 ASP B 386 35.359 31.469 −31.688 1.00 11.65 B O ATOM 14704 OD2 ASP B 386 34.395 30.312 −33.284 1.00 13.99 B O ATOM 14705 C ASP B 386 38.881 29.141 −31.845 1.00 15.56 B C ATOM 14706 O ASP B 386 39.175 28.506 −30.831 1.00 15.59 B O ATOM 14708 N TYR B 387 39.509 28.987 −33.010 1.00 16.18 B N ATOM 14709 CA TYR B 387 40.535 27.961 −33.190 1.00 17.16 B C ATOM 14711 CB TYR B 387 41.021 27.871 −34.639 1.00 17.34 B C ATOM 14714 CG TYR B 387 42.013 26.745 −34.840 1.00 19.17 B C ATOM 14715 CD1 TYR B 387 41.602 25.419 −34.781 1.00 22.10 B C ATOM 14717 CE1 TYR B 387 42.503 24.374 −34.945 1.00 25.04 B C ATOM 14719 CZ TYR B 387 43.839 24.650 −35.170 1.00 26.53 B C ATOM 14720 OH TYR B 387 44.731 23.609 −35.338 1.00 27.53 B O ATOM 14722 CE2 TYR B 387 44.278 25.965 −35.225 1.00 25.30 B C ATOM 14724 CD2 TYR B 387 43.363 27.004 −35.055 1.00 22.56 B C ATOM 14726 C TYR B 387 41.729 28.180 −32.272 1.00 17.41 B C ATOM 14727 O TYR B 387 42.241 27.224 −31.689 1.00 18.04 B O ATOM 14729 N PHE B 388 42.177 29.426 −32.147 1.00 17.25 B N ATOM 14730 CA PHE B 388 43.255 29.726 −31.218 1.00 17.19 B C ATOM 14732 CB PHE B 388 43.803 31.135 −31.406 1.00 16.75 B C ATOM 14735 CG PHE B 388 45.047 31.387 −30.617 1.00 16.33 B C ATOM 14736 CD1 PHE B 388 46.244 30.796 −30.994 1.00 16.78 B C ATOM 14738 CE1 PHE B 388 47.401 31.006 −30.265 1.00 16.25 B C ATOM 14740 CZ PHE B 388 47.369 31.808 −29.137 1.00 16.41 B C ATOM 14742 CE2 PHE B 388 46.175 32.396 −28.742 1.00 16.15 B C ATOM 14744 CD2 PHE B 388 45.021 32.179 −29.479 1.00 16.35 B C ATOM 14746 C PHE B 388 42.778 29.539 −29.783 1.00 17.91 B C ATOM 14747 O PHE B 388 43.468 28.913 −28.979 1.00 18.31 B O ATOM 14749 N GLY B 389 41.590 30.062 −29.475 1.00 18.30 B N ATOM 14750 CA GLY B 389 40.982 29.902 −28.151 1.00 18.22 B C ATOM 14753 C GLY B 389 41.074 28.480 −27.625 1.00 18.15 B C ATOM 14754 O GLY B 389 41.426 28.262 −26.465 1.00 18.35 B O ATOM 14756 N ASN B 390 40.760 27.516 −28.487 1.00 17.78 B N ATOM 14757 CA ASN B 390 40.865 26.097 −28.154 1.00 17.52 B C ATOM 14759 CB ASN B 390 39.912 25.286 −29.037 1.00 17.50 B C ATOM 14762 CG ASN B 390 39.703 23.875 −28.529 1.00 17.13 B C ATOM 14763 OD1 ASN B 390 39.294 23.673 −27.386 1.00 16.19 B O ATOM 14764 ND2 ASN B 390 39.977 22.890 −29.377 1.00 16.14 B N ATOM 14767 C ASN B 390 42.289 25.559 −28.324 1.00 17.35 B C ATOM 14768 O ASN B 390 42.689 24.616 −27.637 1.00 16.87 B O ATOM 14770 N ALA B 391 43.041 26.160 −29.246 1.00 17.15 B N ATOM 14771 CA ALA B 391 44.367 25.670 −29.628 1.00 16.79 B C ATOM 14773 CB ALA B 391 44.874 26.414 −30.850 1.00 16.54 B C ATOM 14777 C ALA B 391 45.402 25.737 −28.507 1.00 16.67 B C ATOM 14778 O ALA B 391 46.229 24.834 −28.386 1.00 17.01 B O ATOM 14780 N TRP B 392 45.378 26.795 −27.700 1.00 16.56 B N ATOM 14781 CA TRP B 392 46.324 26.891 −26.585 1.00 16.79 B C ATOM 14783 CB TRP B 392 46.551 28.339 −26.114 1.00 16.90 B C ATOM 14786 CG TRP B 392 45.347 29.101 −25.644 1.00 16.82 B C ATOM 14787 CD1 TRP B 392 44.616 29.993 −26.368 1.00 17.86 B C ATOM 14789 NE1 TRP B 392 43.604 30.516 −25.601 1.00 19.26 B N ATOM 14791 CE2 TRP B 392 43.675 29.974 −24.346 1.00 19.44 B C ATOM 14792 CD2 TRP B 392 44.770 29.082 −24.333 1.00 18.34 B C ATOM 14793 CE3 TRP B 392 45.061 28.389 −23.152 1.00 20.35 B C ATOM 14795 CZ3 TRP B 392 44.259 28.606 −22.035 1.00 20.88 B C ATOM 14797 CH2 TRP B 392 43.177 29.500 −22.082 1.00 20.79 B C ATOM 14799 CZ2 TRP B 392 42.870 30.192 −23.224 1.00 20.30 B C ATOM 14801 C TRP B 392 45.952 25.973 −25.420 1.00 17.05 B C ATOM 14802 O TRP B 392 46.818 25.598 −24.635 1.00 17.62 B O ATOM 14804 N LYS B 393 44.682 25.596 −25.310 1.00 17.13 B N ATOM 14805 CA LYS B 393 44.297 24.524 −24.390 1.00 17.62 B C ATOM 14807 CB LYS B 393 42.771 24.422 −24.242 1.00 18.17 B C ATOM 14810 CG LYS B 393 42.149 25.470 −23.336 1.00 19.49 B C ATOM 14813 CD LYS B 393 40.637 25.300 −23.251 1.00 20.92 B C ATOM 14816 CE LYS B 393 39.987 26.436 −22.472 1.00 22.85 B C ATOM 14819 NZ LYS B 393 40.242 27.775 −23.089 1.00 23.75 B N ATOM 14823 C LYS B 393 44.855 23.190 −24.891 1.00 17.26 B C ATOM 14824 O LYS B 393 45.466 22.438 −24.130 1.00 17.57 B O ATOM 14826 N SER B 394 44.655 22.917 −26.181 1.00 16.47 B N ATOM 14827 CA SER B 394 45.061 21.644 −26.782 1.00 15.87 B C ATOM 14829 CB SER B 394 44.438 21.474 −28.173 1.00 16.34 B C ATOM 14832 OG SER B 394 45.053 22.324 −29.128 1.00 17.96 B O ATOM 14834 C SER B 394 46.573 21.488 −26.882 1.00 14.74 B C ATOM 14835 O SER B 394 47.064 20.395 −27.163 1.00 14.87 B O ATOM 14837 N SER B 395 47.306 22.581 −26.674 1.00 13.73 B N ATOM 14838 CA SER B 395 48.768 22.536 −26.627 1.00 12.86 B C ATOM 14840 CB SER B 395 49.347 23.953 −26.514 1.00 12.97 B C ATOM 14843 OG SER B 395 49.165 24.500 −25.216 1.00 10.58 B O ATOM 14845 C SER B 395 49.263 21.677 −25.460 1.00 12.10 B C ATOM 14846 O SER B 395 50.306 21.037 −25.563 1.00 12.00 B O ATOM 14848 N SER B 396 48.478 21.661 −24.379 1.00 11.22 B N ATOM 14849 CA SER B 396 48.812 21.023 −23.096 1.00 10.50 B C ATOM 14851 CB SER B 396 49.589 19.704 −23.259 1.00 10.20 B C ATOM 14854 OG SER B 396 50.988 19.921 −23.297 1.00 8.38 B O ATOM 14856 C SER B 396 49.576 21.997 −22.197 1.00 10.26 B C ATOM 14857 O SER B 396 50.076 21.611 −21.138 1.00 9.66 B O ATOM 14859 N GLY B 397 49.637 23.260 −22.623 1.00 9.98 B N ATOM 14860 CA GLY B 397 50.327 24.315 −21.889 1.00 9.92 B C ATOM 14863 C GLY B 397 49.710 24.631 −20.538 1.00 9.97 B C ATOM 14864 O GLY B 397 50.433 24.872 −19.576 1.00 10.10 B O ATOM 14866 N PRO B 398 48.368 24.665 −20.462 1.00 10.22 B N ATOM 14867 CA PRO B 398 47.702 24.796 −19.167 1.00 10.28 B C ATOM 14869 CB PRO B 398 46.239 25.041 −19.547 1.00 10.17 B C ATOM 14872 CG PRO B 398 46.294 25.597 −20.918 1.00 10.28 B C ATOM 14875 CD PRO B 398 47.428 24.886 −21.573 1.00 10.52 B C ATOM 14878 C PRO B 398 47.834 23.548 −18.292 1.00 10.37 B C ATOM 14879 O PRO B 398 48.153 23.664 −17.105 1.00 9.87 B O ATOM 14880 N LEU B 399 47.594 22.372 −18.872 1.00 10.74 B N ATOM 14881 CA LEU B 399 47.682 21.120 −18.118 1.00 10.74 B C ATOM 14883 CB LEU B 399 47.255 19.920 −18.965 1.00 10.40 B C ATOM 14886 CG LEU B 399 47.118 18.589 −18.212 1.00 8.78 B C ATOM 14888 CD1 LEU B 399 46.277 17.619 −19.010 1.00 9.68 B C ATOM 14892 CD2 LEU B 399 48.466 17.965 −17.903 1.00 8.42 B C ATOM 14896 C LEU B 399 49.093 20.911 −17.587 1.00 11.26 B C ATOM 14897 O LEU B 399 49.267 20.586 −16.411 1.00 12.26 B O ATOM 14899 N GLN B 400 50.095 21.095 −18.443 1.00 10.88 B N ATOM 14900 CA GLN B 400 51.482 20.980 −18.000 1.00 10.85 B C ATOM 14902 CB GLN B 400 52.459 21.371 −19.109 1.00 10.68 B C ATOM 14905 CG GLN B 400 52.718 20.268 −20.118 1.00 10.94 B C ATOM 14908 CD GLN B 400 53.840 20.605 −21.075 1.00 10.14 B C ATOM 14909 OE1 GLN B 400 54.874 21.143 −20.674 1.00 8.70 B O ATOM 14910 NE2 GLN B 400 53.650 20.279 −22.347 1.00 10.31 B N ATOM 14913 C GLN B 400 51.726 21.844 −16.768 1.00 11.14 B C ATOM 14914 O GLN B 400 52.241 21.358 −15.761 1.00 11.47 B O ATOM 14916 N LEU B 401 51.329 23.114 −16.845 1.00 11.14 B N ATOM 14917 CA LEU B 401 51.568 24.065 −15.759 1.00 11.06 B C ATOM 14919 CB LEU B 401 51.299 25.498 −16.221 1.00 10.61 B C ATOM 14922 CG LEU B 401 52.308 26.063 −17.224 1.00 11.73 B C ATOM 14924 CD1 LEU B 401 52.040 27.539 −17.482 1.00 12.66 B C ATOM 14928 CD2 LEU B 401 53.736 25.867 −16.738 1.00 15.02 B C ATOM 14932 C LEU B 401 50.761 23.747 −14.499 1.00 11.70 B C ATOM 14933 O LEU B 401 51.333 23.653 −13.412 1.00 12.09 B O ATOM 14935 N VAL B 402 49.448 23.559 −14.633 1.00 12.08 B N ATOM 14936 CA VAL B 402 48.625 23.148 −13.485 1.00 12.19 B C ATOM 14938 CB VAL B 402 47.230 22.621 −13.907 1.00 12.09 B C ATOM 14940 CG1 VAL B 402 46.393 23.736 −14.500 1.00 11.45 B C ATOM 14944 CG2 VAL B 402 46.508 21.992 −12.715 1.00 10.48 B C ATOM 14948 C VAL B 402 49.343 22.055 −12.691 1.00 12.73 B C ATOM 14949 O VAL B 402 49.364 22.090 −11.463 1.00 13.03 B O ATOM 14951 N PHE B 403 49.931 21.096 −13.406 1.00 12.77 B N ATOM 14952 CA PHE B 403 50.689 20.009 −12.789 1.00 12.83 B C ATOM 14954 CB PHE B 403 51.004 18.918 −13.818 1.00 13.10 B C ATOM 14957 CG PHE B 403 50.038 17.776 −13.798 1.00 13.23 B C ATOM 14958 CD1 PHE B 403 50.267 16.676 −12.985 1.00 12.90 B C ATOM 14960 CE1 PHE B 403 49.379 15.618 −12.959 1.00 14.26 B C ATOM 14962 CZ PHE B 403 48.241 15.653 −13.749 1.00 15.62 B C ATOM 14964 CE2 PHE B 403 48.004 16.745 −14.567 1.00 15.30 B C ATOM 14966 CD2 PHE B 403 48.899 17.800 −14.586 1.00 14.00 B C ATOM 14968 C PHE B 403 51.985 20.487 −12.142 1.00 12.73 B C ATOM 14969 O PHE B 403 52.337 20.036 −11.051 1.00 12.37 B O ATOM 14971 N ALA B 404 52.695 21.383 −12.824 1.00 12.86 B N ATOM 14972 CA ALA B 404 53.958 21.925 −12.317 1.00 12.97 B C ATOM 14974 CB ALA B 404 54.659 22.744 −13.395 1.00 12.54 B C ATOM 14978 C ALA B 404 53.750 22.771 −11.062 1.00 13.43 B C ATOM 14979 O ALA B 404 54.665 22.906 −10.247 1.00 13.75 B O ATOM 14981 N TYR B 405 52.549 23.332 −10.915 1.00 13.71 B N ATOM 14982 CA TYR B 405 52.200 24.148 −9.750 1.00 13.86 B C ATOM 14984 CB TYR B 405 50.762 24.667 −9.872 1.00 13.79 B C ATOM 14987 CG TYR B 405 50.254 25.335 −8.618 1.00 13.21 B C ATOM 14988 CD1 TYR B 405 50.594 26.652 −8.323 1.00 12.79 B C ATOM 14990 CE1 TYR B 405 50.136 27.270 −7.170 1.00 11.81 B C ATOM 14992 CZ TYR B 405 49.332 26.565 −6.298 1.00 12.37 B C ATOM 14993 OH TYR B 405 48.878 27.167 −5.154 1.00 12.04 B O ATOM 14995 CE2 TYR B 405 48.983 25.251 −6.566 1.00 12.72 B C ATOM 14997 CD2 TYR B 405 49.444 24.645 −7.720 1.00 12.42 B C ATOM 14999 C TYR B 405 52.357 23.371 −8.446 1.00 14.17 B C ATOM 15000 O TYR B 405 53.016 23.836 −7.515 1.00 14.28 B O ATOM 15002 N PHE B 406 51.753 22.186 −8.391 1.00 14.49 B N ATOM 15003 CA PHE B 406 51.802 21.342 −7.193 1.00 14.68 B C ATOM 15005 CB PHE B 406 50.791 20.197 −7.298 1.00 14.37 B C ATOM 15008 CG PHE B 406 49.360 20.654 −7.391 1.00 13.87 B C ATOM 15009 CD1 PHE B 406 48.612 20.883 −6.246 1.00 13.63 B C ATOM 15011 CE1 PHE B 406 47.290 21.297 −6.334 1.00 12.80 B C ATOM 15013 CZ PHE B 406 46.705 21.484 −7.573 1.00 11.76 B C ATOM 15015 CE2 PHE B 406 47.440 21.257 −8.720 1.00 12.46 B C ATOM 15017 CD2 PHE B 406 48.758 20.843 −8.626 1.00 13.06 B C ATOM 15019 C PHE B 406 53.202 20.774 −6.955 1.00 15.00 B C ATOM 15020 O PHE B 406 53.542 20.387 −5.837 1.00 14.79 B O ATOM 15022 N ALA B 407 54.001 20.725 −8.015 1.00 15.76 B N ATOM 15023 CA ALA B 407 55.372 20.243 −7.940 1.00 16.63 B C ATOM 15025 CB ALA B 407 55.849 19.847 −9.323 1.00 16.82 B C ATOM 15029 C ALA B 407 56.327 21.270 −7.338 1.00 17.61 B C ATOM 15030 O ALA B 407 57.348 20.889 −6.761 1.00 17.54 B O ATOM 15032 N VAL B 408 56.005 22.558 −7.485 1.00 18.76 B N ATOM 15033 CA VAL B 408 56.896 23.644 −7.041 1.00 19.68 B C ATOM 15035 CB VAL B 408 57.122 24.709 −8.151 1.00 19.56 B C ATOM 15037 CG1 VAL B 408 57.867 24.099 −9.326 1.00 20.05 B C ATOM 15041 CG2 VAL B 408 55.809 25.326 −8.608 1.00 19.46 B C ATOM 15045 C VAL B 408 56.422 24.343 −5.765 1.00 20.58 B C ATOM 15046 O VAL B 408 57.217 24.560 −4.850 1.00 20.87 B O ATOM 15048 N VAL B 409 55.137 24.686 −5.700 1.00 21.60 B N ATOM 15049 CA VAL B 409 54.589 25.416 −4.556 1.00 22.34 B C ATOM 15051 CB VAL B 409 53.202 26.016 −4.877 1.00 22.39 B C ATOM 15053 CG1 VAL B 409 52.600 26.674 −3.640 1.00 23.44 B C ATOM 15057 CG2 VAL B 409 53.306 27.019 −6.015 1.00 22.32 B C ATOM 15061 C VAL B 409 54.464 24.492 −3.346 1.00 22.94 B C ATOM 15062 O VAL B 409 53.760 23.483 −3.411 1.00 23.20 B O ATOM 15064 N GLN B 410 55.146 24.841 −2.254 1.00 23.53 B N ATOM 15065 CA GLN B 410 55.110 24.046 −1.021 1.00 24.19 B C ATOM 15067 CB GLN B 410 56.199 24.501 −0.038 1.00 24.35 B C ATOM 15070 CG GLN B 410 57.580 23.913 −0.322 1.00 25.13 B C ATOM 15073 CD GLN B 410 58.700 24.597 0.458 1.00 26.32 B C ATOM 15074 OE1 GLN B 410 58.471 25.217 1.500 1.00 26.11 B O ATOM 15075 NE2 GLN B 410 59.923 24.479 −0.047 1.00 26.55 B N ATOM 15078 C GLN B 410 53.736 24.119 −0.354 1.00 24.67 B C ATOM 15079 O GLN B 410 53.107 23.087 −0.098 1.00 24.94 B O ATOM 15081 N ASN B 411 53.282 25.340 −0.077 1.00 24.76 B N ATOM 15082 CA ASN B 411 51.964 25.568 0.515 1.00 24.87 B C ATOM 15084 CB ASN B 411 52.044 26.607 1.639 1.00 24.93 B C ATOM 15087 CG ASN B 411 52.557 26.022 2.944 1.00 25.27 B C ATOM 15088 OD1 ASN B 411 52.140 26.439 4.027 1.00 25.02 B O ATOM 15089 ND2 ASN B 411 53.458 25.050 2.850 1.00 24.79 B N ATOM 15092 C ASN B 411 50.967 26.024 −0.543 1.00 24.92 B C ATOM 15093 O ASN B 411 50.950 27.198 −0.924 1.00 25.20 B O ATOM 15095 N ILE B 412 50.145 25.091 −1.017 1.00 24.78 B N ATOM 15096 CA ILE B 412 49.102 25.407 −1.996 1.00 24.69 B C ATOM 15098 CB ILE B 412 48.471 24.130 −2.625 1.00 24.72 B C ATOM 15100 CG1 ILE B 412 47.696 23.311 −1.585 1.00 24.16 B C ATOM 15103 CD1 ILE B 412 47.342 21.919 −2.059 1.00 23.73 B C ATOM 15107 CG2 ILE B 412 49.546 23.272 −3.289 1.00 25.19 B C ATOM 15111 C ILE B 412 48.015 26.260 −1.350 1.00 24.62 B C ATOM 15112 O ILE B 412 47.701 26.086 −0.176 1.00 24.66 B O ATOM 15114 N LYS B 413 47.457 27.187 −2.121 1.00 24.99 B N ATOM 15115 CA LYS B 413 46.396 28.065 −1.635 1.00 25.75 B C ATOM 15117 CB LYS B 413 46.871 29.520 −1.653 1.00 25.95 B C ATOM 15120 CG LYS B 413 48.243 29.716 −1.015 1.00 28.01 B C ATOM 15123 CD LYS B 413 48.538 31.179 −0.705 1.00 30.48 B C ATOM 15126 CE LYS B 413 49.825 31.320 0.103 1.00 31.81 B C ATOM 15129 NZ LYS B 413 50.059 32.715 0.570 1.00 32.42 B N ATOM 15133 C LYS B 413 45.152 27.892 −2.505 1.00 25.95 B C ATOM 15134 O LYS B 413 45.254 27.868 −3.735 1.00 26.19 B O ATOM 15136 N LYS B 414 43.983 27.762 −1.874 1.00 25.87 B N ATOM 15137 CA LYS B 414 42.731 27.596 −2.619 1.00 25.83 B C ATOM 15139 CB LYS B 414 41.512 27.515 −1.691 1.00 26.36 B C ATOM 15142 CG LYS B 414 40.168 27.499 −2.450 1.00 27.62 B C ATOM 15145 CD LYS B 414 38.978 27.133 −1.562 1.00 28.07 B C ATOM 15148 CE LYS B 414 38.690 28.200 −0.508 1.00 28.15 B C ATOM 15151 NZ LYS B 414 38.573 29.575 −1.081 1.00 27.51 B N ATOM 15155 C LYS B 414 42.547 28.730 −3.622 1.00 25.45 B C ATOM 15156 O LYS B 414 42.039 28.512 −4.721 1.00 25.62 B O ATOM 15158 N GLU B 415 42.958 29.936 −3.235 1.00 24.98 B N ATOM 15159 CA GLU B 415 42.926 31.092 −4.133 1.00 24.62 B C ATOM 15161 CB GLU B 415 43.333 32.377 −3.388 1.00 24.74 B C ATOM 15164 CG GLU B 415 44.180 33.364 −4.212 1.00 25.93 B C ATOM 15167 CD GLU B 415 43.994 34.813 −3.804 1.00 26.17 B C ATOM 15168 OE1 GLU B 415 43.609 35.076 −2.646 1.00 28.18 B O ATOM 15169 OE2 GLU B 415 44.241 35.695 −4.655 1.00 26.04 B O ATOM 15170 C GLU B 415 43.788 30.877 −5.386 1.00 23.90 B C ATOM 15171 O GLU B 415 43.367 31.210 −6.495 1.00 23.91 B O ATOM 15173 N GLU B 416 44.986 30.326 −5.209 1.00 23.17 B N ATOM 15174 CA GLU B 416 45.878 30.058 −6.338 1.00 22.78 B C ATOM 15176 CB GLU B 416 47.261 29.608 −5.855 1.00 23.14 B C ATOM 15179 CG GLU B 416 48.181 30.755 −5.454 1.00 23.54 B C ATOM 15182 CD GLU B 416 49.543 30.288 −4.962 1.00 24.77 B C ATOM 15183 OE1 GLU B 416 49.646 29.171 −4.411 1.00 24.46 B O ATOM 15184 OE2 GLU B 416 50.518 31.050 −5.120 1.00 26.91 B O ATOM 15185 C GLU B 416 45.285 29.017 −7.284 1.00 22.07 B C ATOM 15186 O GLU B 416 45.196 29.253 −8.490 1.00 21.50 B O ATOM 15188 N ILE B 417 44.874 27.875 −6.737 1.00 21.72 B N ATOM 15189 CA ILE B 417 44.253 26.822 −7.551 1.00 22.01 B C ATOM 15191 CB ILE B 417 44.108 25.472 −6.790 1.00 22.11 B C ATOM 15193 CG1 ILE B 417 43.194 25.610 −5.576 1.00 22.41 B C ATOM 15196 CD1 ILE B 417 43.202 24.395 −4.674 1.00 23.93 B C ATOM 15200 CG2 ILE B 417 45.473 24.951 −6.362 1.00 22.61 B C ATOM 15204 C ILE B 417 42.898 27.249 −8.132 1.00 22.01 B C ATOM 15205 O ILE B 417 42.449 26.680 −9.127 1.00 21.57 B O ATOM 15207 N GLU B 418 42.256 28.241 −7.512 1.00 22.40 B N ATOM 15208 CA GLU B 418 41.029 28.841 −8.064 1.00 22.66 B C ATOM 15210 CB GLU B 418 40.379 29.814 −7.068 1.00 22.95 B C ATOM 15213 CG GLU B 418 39.241 29.216 −6.250 1.00 24.26 B C ATOM 15216 CD GLU B 418 38.507 30.261 −5.428 1.00 26.39 B C ATOM 15217 OE1 GLU B 418 39.152 31.244 −5.003 1.00 26.91 B O ATOM 15218 OE2 GLU B 418 37.287 30.099 −5.207 1.00 27.64 B O ATOM 15219 C GLU B 418 41.288 29.568 −9.384 1.00 22.19 B C ATOM 15220 O GLU B 418 40.467 29.507 −10.302 1.00 22.03 B O ATOM 15222 N ASN B 419 42.419 30.263 −9.468 1.00 21.74 B N ATOM 15223 CA ASN B 419 42.819 30.931 −10.704 1.00 21.85 B C ATOM 15225 CB ASN B 419 43.803 32.069 −10.409 1.00 21.97 B C ATOM 15228 CG ASN B 419 43.112 33.305 −9.840 1.00 22.96 B C ATOM 15229 OD1 ASN B 419 42.276 33.922 −10.503 1.00 24.59 B O ATOM 15230 ND2 ASN B 419 43.462 33.670 −8.609 1.00 22.29 B N ATOM 15233 C ASN B 419 43.392 29.954 −11.739 1.00 21.82 B C ATOM 15234 O ASN B 419 43.309 30.208 −12.942 1.00 21.68 B O ATOM 15236 N LEU B 420 43.961 28.840 −11.271 1.00 21.94 B N ATOM 15237 CA LEU B 420 44.408 27.760 −12.166 1.00 21.70 B C ATOM 15239 CB LEU B 420 45.147 26.654 −11.400 1.00 21.08 B C ATOM 15242 CG LEU B 420 46.618 26.901 −11.057 1.00 20.18 B C ATOM 15244 CD1 LEU B 420 47.124 25.869 −10.057 1.00 18.62 B C ATOM 15248 CD2 LEU B 420 47.477 26.901 −12.313 1.00 17.37 B C ATOM 15252 C LEU B 420 43.228 27.145 −12.903 1.00 22.21 B C ATOM 15253 O LEU B 420 43.283 26.956 −14.118 1.00 22.19 B O ATOM 15255 N GLN B 421 42.166 26.832 −12.160 1.00 22.92 B N ATOM 15256 CA GLN B 421 40.958 26.240 −12.739 1.00 23.57 B C ATOM 15258 CB GLN B 421 39.911 25.943 −11.656 1.00 24.09 B C ATOM 15261 CG GLN B 421 40.296 24.803 −10.706 1.00 26.83 B C ATOM 15264 CD GLN B 421 39.112 23.933 −10.302 1.00 29.79 B C ATOM 15265 OE1 GLN B 421 39.061 22.742 −10.627 1.00 31.64 B O ATOM 15266 NE2 GLN B 421 38.151 24.525 −9.597 1.00 29.87 B N ATOM 15269 C GLN B 421 40.351 27.135 −13.812 1.00 23.57 B C ATOM 15270 O GLN B 421 39.842 26.637 −14.815 1.00 23.53 B O ATOM 15272 N LYS B 422 40.430 28.451 −13.605 1.00 24.03 B N ATOM 15273 CA LYS B 422 39.860 29.436 −14.534 1.00 24.54 B C ATOM 15275 CB LYS B 422 39.330 30.643 −13.747 1.00 24.69 B C ATOM 15278 CG LYS B 422 38.068 30.312 −12.950 1.00 27.40 B C ATOM 15281 CD LYS B 422 37.853 31.231 −11.748 1.00 30.16 B C ATOM 15284 CE LYS B 422 36.737 30.695 −10.844 1.00 30.51 B C ATOM 15287 NZ LYS B 422 36.523 31.525 −9.621 1.00 30.84 B N ATOM 15291 C LYS B 422 40.832 29.882 −15.638 1.00 24.42 B C ATOM 15292 O LYS B 422 40.546 30.833 −16.366 1.00 24.81 B O ATOM 15294 N TYR B 423 41.960 29.182 −15.770 1.00 24.16 B N ATOM 15295 CA TYR B 423 42.965 29.458 −16.803 1.00 23.64 B C ATOM 15297 CB TYR B 423 42.480 28.982 −18.182 1.00 23.69 B C ATOM 15300 CG TYR B 423 42.338 27.472 −18.292 1.00 24.59 B C ATOM 15301 CD1 TYR B 423 43.353 26.622 −17.849 1.00 25.56 B C ATOM 15303 CE1 TYR B 423 43.233 25.243 −17.942 1.00 25.98 B C ATOM 15305 CZ TYR B 423 42.096 24.691 −18.492 1.00 26.45 B C ATOM 15306 OH TYR B 423 41.994 23.323 −18.576 1.00 26.60 B O ATOM 15308 CE2 TYR B 423 41.073 25.506 −18.948 1.00 26.05 B C ATOM 15310 CD2 TYR B 423 41.200 26.892 −18.848 1.00 25.18 B C ATOM 15312 C TYR B 423 43.372 30.927 −16.826 1.00 23.30 B C ATOM 15313 O TYR B 423 43.079 31.657 −17.773 1.00 23.79 B O ATOM 15315 N HIS B 424 44.058 31.333 −15.762 1.00 22.79 B N ATOM 15316 CA HIS B 424 44.483 32.715 −15.553 1.00 22.25 B C ATOM 15318 CB HIS B 424 44.798 32.915 −14.065 1.00 22.47 B C ATOM 15321 CG HIS B 424 45.182 34.313 −13.699 1.00 23.17 B C ATOM 15322 ND1 HIS B 424 46.491 34.738 −13.664 1.00 22.23 B N ATOM 15324 CE1 HIS B 424 46.531 36.009 −13.308 1.00 22.45 B C ATOM 15326 NE2 HIS B 424 45.294 36.424 −13.106 1.00 23.39 B N ATOM 15328 CD2 HIS B 424 44.430 35.381 −13.342 1.00 23.99 B C ATOM 15330 C HIS B 424 45.701 33.058 −16.415 1.00 21.56 B C ATOM 15331 O HIS B 424 46.434 32.167 −16.845 1.00 21.55 B O ATOM 15333 N ASP B 425 45.898 34.354 −16.659 1.00 21.01 B N ATOM 15334 CA ASP B 425 47.006 34.875 −17.482 1.00 20.76 B C ATOM 15336 CB ASP B 425 47.157 36.385 −17.267 1.00 20.81 B C ATOM 15339 CG ASP B 425 45.982 37.171 −17.801 1.00 21.95 B C ATOM 15340 OD1 ASP B 425 45.764 37.140 −19.030 1.00 23.03 B O ATOM 15341 OD2 ASP B 425 45.281 37.822 −16.994 1.00 22.61 B O ATOM 15342 C ASP B 425 48.365 34.217 −17.228 1.00 20.21 B C ATOM 15343 O ASP B 425 49.082 33.880 −18.172 1.00 20.00 B O ATOM 15345 N THR B 426 48.711 34.052 −15.952 1.00 19.50 B N ATOM 15346 CA THR B 426 50.011 33.510 −15.545 1.00 18.64 B C ATOM 15348 CB THR B 426 50.061 33.267 −14.021 1.00 18.27 B C ATOM 15350 OG1 THR B 426 50.051 34.525 −13.335 1.00 17.93 B O ATOM 15352 CG2 THR B 426 51.313 32.502 −13.632 1.00 17.94 B C ATOM 15356 C THR B 426 50.362 32.216 −16.278 1.00 18.30 B C ATOM 15357 O THR B 426 51.519 32.012 −16.657 1.00 18.29 B O ATOM 15359 N ILE B 427 49.364 31.355 −16.479 1.00 17.83 B N ATOM 15360 CA ILE B 427 49.556 30.106 −17.222 1.00 17.71 B C ATOM 15362 CB ILE B 427 48.948 28.885 −16.472 1.00 17.30 B C ATOM 15364 CG1 ILE B 427 47.417 28.906 −16.489 1.00 16.67 B C ATOM 15367 CD1 ILE B 427 46.803 27.717 −15.792 1.00 15.11 B C ATOM 15371 CG2 ILE B 427 49.449 28.846 −15.039 1.00 16.16 B C ATOM 15375 C ILE B 427 49.025 30.172 −18.663 1.00 18.09 B C ATOM 15376 O ILE B 427 49.557 29.498 −19.547 1.00 17.89 B O ATOM 15378 N SER B 428 47.997 30.985 −18.904 1.00 18.49 B N ATOM 15379 CA SER B 428 47.379 31.056 −20.232 1.00 18.89 B C ATOM 15381 CB SER B 428 46.036 31.794 −20.180 1.00 19.00 B C ATOM 15384 OG SER B 428 46.211 33.200 −20.223 1.00 19.67 B O ATOM 15386 C SER B 428 48.296 31.721 −21.255 1.00 19.28 B C ATOM 15387 O SER B 428 48.416 31.245 −22.382 1.00 19.91 B O ATOM 15389 N ARG B 429 48.940 32.818 −20.858 1.00 19.47 B N ATOM 15390 CA ARG B 429 49.798 33.597 −21.763 1.00 19.36 B C ATOM 15392 CB ARG B 429 50.349 34.838 −21.056 1.00 19.70 B C ATOM 15395 CG ARG B 429 49.283 35.843 −20.642 1.00 22.63 B C ATOM 15398 CD ARG B 429 49.315 37.104 −21.490 1.00 25.32 B C ATOM 15401 NE ARG B 429 48.208 38.001 −21.157 1.00 26.37 B N ATOM 15403 CZ ARG B 429 47.010 37.998 −21.745 1.00 27.17 B C ATOM 15404 NH1 ARG B 429 46.725 37.144 −22.725 1.00 26.90 B N ATOM 15407 NH2 ARG B 429 46.084 38.865 −21.349 1.00 28.32 B N ATOM 15410 C ARG B 429 50.948 32.784 −22.364 1.00 18.47 B C ATOM 15411 O ARG B 429 51.117 32.783 −23.577 1.00 17.94 B O ATOM 15413 N PRO B 430 51.742 32.087 −21.528 1.00 18.01 B N ATOM 15414 CA PRO B 430 52.794 31.255 −22.123 1.00 17.76 B C ATOM 15416 CB PRO B 430 53.597 30.774 −20.909 1.00 17.79 B C ATOM 15419 CG PRO B 430 52.661 30.880 −19.766 1.00 18.19 B C ATOM 15422 CD PRO B 430 51.791 32.058 −20.056 1.00 17.89 B C ATOM 15425 C PRO B 430 52.255 30.068 −22.933 1.00 17.32 B C ATOM 15426 O PRO B 430 52.989 29.504 −23.746 1.00 17.56 B O ATOM 15427 N SER B 431 50.996 29.693 −22.710 1.00 16.49 B N ATOM 15428 CA SER B 431 50.328 28.702 −23.554 1.00 16.00 B C ATOM 15430 CB SER B 431 49.131 28.086 −22.830 1.00 15.98 B C ATOM 15433 OG SER B 431 49.521 27.553 −21.578 1.00 15.79 B O ATOM 15435 C SER B 431 49.896 29.310 −24.895 1.00 15.50 B C ATOM 15436 O SER B 431 49.769 28.595 −25.890 1.00 15.19 B O ATOM 15438 N HIS B 432 49.662 30.623 −24.919 1.00 15.14 B N ATOM 15439 CA HIS B 432 49.510 31.350 −26.183 1.00 14.91 B C ATOM 15441 CB HIS B 432 49.203 32.841 −25.952 1.00 14.78 B C ATOM 15444 CG HIS B 432 47.812 33.122 −25.471 1.00 14.57 B C ATOM 15445 ND1 HIS B 432 47.099 32.248 −24.679 1.00 15.65 B N ATOM 15447 CE1 HIS B 432 45.914 32.766 −24.408 1.00 14.74 B C ATOM 15449 NE2 HIS B 432 45.836 33.951 −24.985 1.00 13.39 B N ATOM 15451 CD2 HIS B 432 47.013 34.200 −25.650 1.00 14.77 B C ATOM 15453 C HIS B 432 50.807 31.224 −26.984 1.00 14.58 B C ATOM 15454 O HIS B 432 50.786 30.909 −28.172 1.00 14.38 B O ATOM 15456 N ILE B 433 51.931 31.455 −26.307 1.00 14.30 B N ATOM 15457 CA ILE B 433 53.258 31.391 −26.919 1.00 13.69 B C ATOM 15459 CB ILE B 433 54.357 31.939 −25.968 1.00 13.55 B C ATOM 15461 CG1 ILE B 433 54.064 33.386 −25.550 1.00 13.14 B C ATOM 15464 CD1 ILE B 433 54.088 34.380 −26.682 1.00 11.73 B C ATOM 15468 CG2 ILE B 433 55.734 31.857 −26.623 1.00 13.05 B C ATOM 15472 C ILE B 433 53.627 29.958 −27.303 1.00 13.75 B C ATOM 15473 O ILE B 433 54.393 29.743 −28.240 1.00 14.58 B O ATOM 15475 N PHE B 434 53.088 28.982 −26.578 1.00 13.11 B N ATOM 15476 CA PHE B 434 53.363 27.570 −26.851 1.00 12.79 B C ATOM 15478 CB PHE B 434 52.916 26.726 −25.648 1.00 12.75 B C ATOM 15481 CG PHE B 434 53.066 25.231 −25.822 1.00 13.16 B C ATOM 15482 CD1 PHE B 434 53.915 24.668 −26.771 1.00 13.37 B C ATOM 15484 CE1 PHE B 434 54.026 23.285 −26.894 1.00 13.68 B C ATOM 15486 CZ PHE B 434 53.311 22.454 −26.049 1.00 12.83 B C ATOM 15488 CE2 PHE B 434 52.482 23.002 −25.092 1.00 13.60 B C ATOM 15490 CD2 PHE B 434 52.367 24.379 −24.978 1.00 14.39 B C ATOM 15492 C PHE B 434 52.689 27.132 −28.153 1.00 12.75 B C ATOM 15493 O PHE B 434 53.341 26.578 −29.036 1.00 12.94 B O ATOM 15495 N ARG B 435 51.397 27.409 −28.278 1.00 12.65 B N ATOM 15496 CA ARG B 435 50.647 27.077 −29.490 1.00 12.43 B C ATOM 15498 CB ARG B 435 49.146 27.269 −29.238 1.00 12.62 B C ATOM 15501 CG ARG B 435 48.244 27.150 −30.463 1.00 13.62 B C ATOM 15504 CD ARG B 435 48.426 25.839 −31.211 1.00 15.01 B C ATOM 15507 NE ARG B 435 48.056 24.675 −30.411 1.00 15.74 B N ATOM 15509 CZ ARG B 435 48.332 23.415 −30.739 1.00 17.48 B C ATOM 15510 NH1 ARG B 435 48.997 23.124 −31.856 1.00 18.48 B N ATOM 15513 NH2 ARG B 435 47.948 22.434 −29.936 1.00 18.57 B N ATOM 15516 C ARG B 435 51.098 27.898 −30.708 1.00 12.48 B C ATOM 15517 O ARG B 435 51.168 27.370 −31.817 1.00 12.61 B O ATOM 15519 N LEU B 436 51.401 29.180 −30.504 1.00 12.45 B N ATOM 15520 CA LEU B 436 51.812 30.060 −31.606 1.00 12.32 B C ATOM 15522 CB LEU B 436 51.884 31.521 −31.153 1.00 12.22 B C ATOM 15525 CG LEU B 436 50.576 32.303 −31.063 1.00 11.85 B C ATOM 15527 CD1 LEU B 436 50.876 33.761 −30.737 1.00 12.49 B C ATOM 15531 CD2 LEU B 436 49.782 32.196 −32.351 1.00 11.29 B C ATOM 15535 C LEU B 436 53.153 29.669 −32.225 1.00 12.83 B C ATOM 15536 O LEU B 436 53.335 29.800 −33.433 1.00 12.98 B O ATOM 15538 N CYS B 437 54.093 29.214 −31.402 1.00 13.39 B N ATOM 15539 CA CYS B 437 55.387 28.759 −31.903 1.00 13.88 B C ATOM 15541 CB CYS B 437 56.381 28.581 −30.753 1.00 13.94 B C ATOM 15544 SG CYS B 437 56.826 30.125 −29.910 1.00 15.60 B S ATOM 15546 C CYS B 437 55.219 27.449 −32.668 1.00 14.16 B C ATOM 15547 O CYS B 437 55.625 27.343 −33.825 1.00 14.34 B O ATOM 15549 N ASN B 438 54.602 26.466 −32.014 1.00 14.40 B N ATOM 15550 CA ASN B 438 54.336 25.156 −32.612 1.00 14.88 B C ATOM 15552 CB ASN B 438 53.450 24.324 −31.674 1.00 15.18 B C ATOM 15555 CG ASN B 438 52.919 23.050 −32.324 1.00 16.21 B C ATOM 15556 OD1 ASN B 438 51.766 22.669 −32.104 1.00 17.51 B O ATOM 15557 ND2 ASN B 438 53.754 22.387 −33.122 1.00 16.34 B N ATOM 15560 C ASN B 438 53.687 25.252 −33.991 1.00 14.99 B C ATOM 15561 O ASN B 438 54.140 24.613 −34.941 1.00 15.21 B O ATOM 15563 N ASP B 439 52.623 26.042 −34.091 1.00 15.13 B N ATOM 15564 CA ASP B 439 51.912 26.202 −35.358 1.00 15.33 B C ATOM 15566 CB ASP B 439 50.546 26.880 −35.147 1.00 15.20 B C ATOM 15569 CG ASP B 439 49.512 25.946 −34.501 1.00 14.78 B C ATOM 15570 OD1 ASP B 439 49.909 24.940 −33.876 1.00 13.59 B O ATOM 15571 OD2 ASP B 439 48.295 26.218 −34.619 1.00 13.26 B O ATOM 15572 C ASP B 439 52.767 26.968 −36.374 1.00 15.73 B C ATOM 15573 O ASP B 439 52.689 26.698 −37.574 1.00 15.79 B O ATOM 15575 N LEU B 440 53.587 27.904 −35.892 1.00 16.14 B N ATOM 15576 CA LEU B 440 54.514 28.640 −36.761 1.00 16.51 B C ATOM 15578 CB LEU B 440 55.158 29.824 −36.031 1.00 16.13 B C ATOM 15581 CG LEU B 440 54.414 31.156 −36.092 1.00 15.62 B C ATOM 15583 CD1 LEU B 440 55.083 32.170 −35.174 1.00 15.61 B C ATOM 15587 CD2 LEU B 440 54.358 31.676 −37.520 1.00 14.42 B C ATOM 15591 C LEU B 440 55.611 27.737 −37.316 1.00 17.37 B C ATOM 15592 O LEU B 440 56.085 27.949 −38.432 1.00 18.00 B O ATOM 15594 N ALA B 441 56.017 26.742 −36.534 1.00 18.07 B N ATOM 15595 CA ALA B 441 57.053 25.804 −36.962 1.00 18.79 B C ATOM 15597 CB ALA B 441 57.436 24.880 −35.814 1.00 18.94 B C ATOM 15601 C ALA B 441 56.608 24.984 −38.173 1.00 19.39 B C ATOM 15602 O ALA B 441 57.367 24.821 −39.130 1.00 19.34 B O ATOM 15604 N SER B 442 55.372 24.488 −38.129 1.00 20.04 B N ATOM 15605 CA SER B 442 54.835 23.620 −39.178 1.00 20.72 B C ATOM 15607 CB SER B 442 54.010 22.503 −38.537 1.00 20.68 B C ATOM 15610 OG SER B 442 52.872 23.030 −37.876 1.00 21.27 B O ATOM 15612 C SER B 442 53.970 24.359 −40.208 1.00 21.39 B C ATOM 15613 O SER B 442 53.341 23.722 −41.055 1.00 21.51 B O ATOM 15615 N ALA B 443 53.953 25.690 −40.147 1.00 22.14 B N ATOM 15616 CA ALA B 443 53.036 26.503 −40.957 1.00 22.64 B C ATOM 15618 CB ALA B 443 53.249 27.988 −40.666 1.00 22.67 B C ATOM 15622 C ALA B 443 53.139 26.241 −42.463 1.00 22.85 B C ATOM 15623 O ALA B 443 52.206 25.712 −43.068 1.00 22.40 B O ATOM 15625 N SER B 444 54.274 26.603 −43.056 1.00 23.46 B N ATOM 15626 CA SER B 444 54.460 26.513 −44.509 1.00 24.13 B C ATOM 15628 CB SER B 444 55.851 27.015 −44.903 1.00 24.32 B C ATOM 15631 OG SER B 444 56.864 26.161 −44.398 1.00 25.37 B O ATOM 15633 C SER B 444 54.251 25.097 −45.053 1.00 24.33 B C ATOM 15634 O SER B 444 53.795 24.925 −46.184 1.00 24.33 B O ATOM 15636 N ALA B 445 54.595 24.093 −44.249 1.00 24.60 B N ATOM 15637 CA ALA B 445 54.375 22.696 −44.615 1.00 24.55 B C ATOM 15639 CB ALA B 445 55.038 21.770 −43.601 1.00 24.40 B C ATOM 15643 C ALA B 445 52.881 22.400 −44.706 1.00 24.64 B C ATOM 15644 O ALA B 445 52.380 22.032 −45.767 1.00 24.53 B O ATOM 15646 N GLU B 446 52.176 22.587 −43.593 1.00 24.83 B N ATOM 15647 CA GLU B 446 50.743 22.289 −43.516 1.00 25.12 B C ATOM 15649 CB GLU B 446 50.230 22.457 −42.075 1.00 25.24 B C ATOM 15652 CG GLU B 446 50.805 21.427 −41.088 1.00 26.42 B C ATOM 15655 CD GLU B 446 50.271 21.565 −39.660 1.00 27.29 B C ATOM 15656 OE1 GLU B 446 49.633 22.589 −39.336 1.00 29.11 B O ATOM 15657 OE2 GLU B 446 50.500 20.638 −38.853 1.00 26.37 B O ATOM 15658 C GLU B 446 49.912 23.137 −44.488 1.00 25.03 B C ATOM 15659 O GLU B 446 48.903 22.667 −45.013 1.00 25.21 B O ATOM 15661 N ILE B 447 50.343 24.373 −44.734 1.00 24.84 B N ATOM 15662 CA ILE B 447 49.633 25.274 −45.647 1.00 24.77 B C ATOM 15664 CB ILE B 447 50.218 26.709 −45.600 1.00 24.76 B C ATOM 15666 CG1 ILE B 447 49.850 27.386 −44.276 1.00 24.75 B C ATOM 15669 CD1 ILE B 447 50.783 28.510 −43.879 1.00 24.00 B C ATOM 15673 CG2 ILE B 447 49.706 27.547 −46.771 1.00 23.20 B C ATOM 15677 C ILE B 447 49.653 24.752 −47.085 1.00 25.09 B C ATOM 15678 O ILE B 447 48.612 24.699 −47.742 1.00 25.20 B O ATOM 15680 N ALA B 448 50.835 24.358 −47.560 1.00 25.30 B N ATOM 15681 CA ALA B 448 51.005 23.871 −48.935 1.00 25.10 B C ATOM 15683 CB ALA B 448 52.485 23.792 −49.294 1.00 24.84 B C ATOM 15687 C ALA B 448 50.323 22.521 −49.183 1.00 25.08 B C ATOM 15688 O ALA B 448 50.005 22.192 −50.324 1.00 25.19 B O ATOM 15690 N ARG B 449 50.106 21.745 −48.121 1.00 25.21 B N ATOM 15691 CA ARG B 449 49.342 20.495 −48.214 1.00 25.32 B C ATOM 15693 CB ARG B 449 49.540 19.636 −46.964 1.00 25.46 B C ATOM 15696 CG ARG B 449 50.959 19.185 −46.680 1.00 25.13 B C ATOM 15699 CD ARG B 449 50.986 18.373 −45.391 1.00 24.41 B C ATOM 15702 NE ARG B 449 52.221 18.551 −44.632 1.00 24.69 B N ATOM 15704 CZ ARG B 449 52.395 18.161 −43.368 1.00 24.86 B C ATOM 15705 NH1 ARG B 449 51.412 17.563 −42.698 1.00 25.32 B N ATOM 15708 NH2 ARG B 449 53.561 18.372 −42.765 1.00 24.17 B N ATOM 15711 C ARG B 449 47.843 20.749 −48.357 1.00 25.44 B C ATOM 15712 O ARG B 449 47.103 19.868 −48.793 1.00 25.60 B O ATOM 15714 N GLY B 450 47.399 21.940 −47.961 1.00 25.52 B N ATOM 15715 CA GLY B 450 45.978 22.269 −47.919 1.00 25.45 B C ATOM 15718 C GLY B 450 45.347 21.972 −46.568 1.00 25.40 B C ATOM 15719 O GLY B 450 44.125 21.849 −46.471 1.00 25.56 B O ATOM 15721 N GLU B 451 46.171 21.852 −45.525 1.00 25.17 B N ATOM 15722 CA GLU B 451 45.666 21.675 −44.162 1.00 25.18 B C ATOM 15724 CB GLU B 451 46.685 20.956 −43.271 1.00 25.44 B C ATOM 15727 CG GLU B 451 46.811 19.460 −43.546 1.00 26.78 B C ATOM 15730 CD GLU B 451 47.637 18.724 −42.496 1.00 28.97 B C ATOM 15731 OE1 GLU B 451 47.800 19.2 −41.368 1.00 30.01 B O ATOM 15732 OE2 GLU B 451 48.122 17.6 −42.799 1.00 30.31 B O ATOM 15733 C GLU B 451 45.308 23.029 −43.551 1.00 24.68 B C ATOM 15734 O GLU B 451 46.039 24.007 −43.716 1.00 24.69 B O ATOM 15736 N THR B 452 44.179 23.069 −42.845 1.00 24.05 B N ATOM 15737 CA THR B 452 43.680 24.299 −42.223 1.00 23.13 B C ATOM 15739 CB THR B 452 42.176 24.536 −42.552 1.00 23.21 B C ATOM 15741 OG1 THR B 452 41.494 23.281 −42.679 1.00 22.65 B O ATOM 15743 CG2 THR B 452 42.023 25.322 −43.850 1.00 22.06 B C ATOM 15747 C THR B 452 43.878 24.338 −40.702 1.00 22.26 B C ATOM 15748 O THR B 452 43.816 25.416 −40.107 1.00 22.08 B O ATOM 15750 N ALA B 453 44.119 23.182 −40.078 1.00 21.27 B N ATOM 15751 CA ALA B 453 44.318 23.105 −38.624 1.00 20.51 B C ATOM 15753 CB ALA B 453 44.174 21.670 −38.137 1.00 20.50 B C ATOM 15757 C ALA B 453 45.680 23.674 −38.222 1.00 20.10 B C ATOM 15758 O ALA B 453 46.590 22.946 −37.816 1.00 20.31 B O ATOM 15760 N ASN B 454 45.793 24.992 −38.343 1.00 19.21 B N ATOM 15761 CA ASN B 454 46.991 25.736 −37.982 1.00 17.99 B C ATOM 15763 CB ASN B 454 48.020 25.682 −39.117 1.00 17.83 B C ATOM 15766 CG ASN B 454 49.386 26.230 −38.709 1.00 17.61 B C ATOM 15767 OD1 ASN B 454 49.581 27.442 −38.617 1.00 17.15 B O ATOM 15768 ND2 ASN B 454 50.341 25.334 −38.485 1.00 16.02 B N ATOM 15771 C ASN B 454 46.555 27.168 −37.705 1.00 17.02 B C ATOM 15772 O ASN B 454 45.631 27.671 −38.343 1.00 16.92 B O ATOM 15774 N SER B 455 47.198 27.816 −36.743 1.00 16.17 B N ATOM 15775 CA SER B 455 46.830 29.178 −36.373 1.00 15.49 B C ATOM 15777 CB SER B 455 47.504 29.571 −35.061 1.00 15.49 B C ATOM 15780 OG SER B 455 47.026 28.759 −34.002 1.00 15.01 B O ATOM 15782 C SER B 455 47.165 30.177 −37.482 1.00 15.01 B C ATOM 15783 O SER B 455 46.369 31.068 −37.780 1.00 14.87 B O ATOM 15785 N VAL B 456 48.331 30.015 −38.104 1.00 14.62 B N ATOM 15786 CA VAL B 456 48.729 30.885 −39.214 1.00 14.23 B C ATOM 15788 CB VAL B 456 50.186 30.623 −39.660 1.00 13.71 B C ATOM 15790 CG1 VAL B 456 50.564 31.530 −40.820 1.00 12.75 B C ATOM 15794 CG2 VAL B 456 51.140 30.836 −38.498 1.00 12.43 B C ATOM 15798 C VAL B 456 47.769 30.725 −40.399 1.00 14.74 B C ATOM 15799 O VAL B 456 47.520 31.682 −41.133 1.00 15.01 B O ATOM 15801 N SER B 457 47.228 29.521 −40.573 1.00 15.08 B N ATOM 15802 CA SER B 457 46.194 29.275 −41.579 1.00 15.28 B C ATOM 15804 CB SER B 457 45.918 27.775 −41.728 1.00 15.22 B C ATOM 15807 OG SER B 457 44.712 27.543 −42.437 1.00 15.09 B O ATOM 15809 C SER B 457 44.902 30.009 −41.227 1.00 15.53 B C ATOM 15810 O SER B 457 44.311 30.663 −42.082 1.00 15.71 B O ATOM 15812 N CYS B 458 44.469 29.893 −39.973 1.00 15.80 B N ATOM 15813 CA CYS B 458 43.245 30.559 −39.515 1.00 16.11 B C ATOM 15815 CB CYS B 458 42.912 30.183 −38.070 1.00 15.87 B C ATOM 15818 SG CYS B 458 42.128 28.572 −37.880 1.00 18.08 B S ATOM 15820 C CYS B 458 43.354 32.072 −39.628 1.00 16.21 B C ATOM 15821 O CYS B 458 42.379 32.744 −39.968 1.00 17.07 B O ATOM 15823 N TYR B 459 44.539 32.602 −39.342 1.00 15.90 B N ATOM 15824 CA TYR B 459 44.771 34.039 −39.424 1.00 15.53 B C ATOM 15826 CB TYR B 459 46.084 34.420 −38.727 1.00 15.20 B C ATOM 15829 CG TYR B 459 46.116 35.848 −38.221 1.00 13.77 B C ATOM 15830 CD1 TYR B 459 45.880 36.142 −36.880 1.00 11.99 B C ATOM 15832 CE1 TYR B 459 45.906 37.452 −36.416 1.00 10.67 B C ATOM 15834 CZ TYR B 459 46.170 38.483 −37.298 1.00 10.73 B C ATOM 15835 OH TYR B 459 46.202 39.785 −36.855 1.00 12.04 B O ATOM 15837 CE2 TYR B 459 46.406 38.216 −38.630 1.00 11.92 B C ATOM 15839 CD2 TYR B 459 46.376 36.906 −39.086 1.00 13.04 B C ATOM 15841 C TYR B 459 44.765 34.507 −40.884 1.00 15.64 B C ATOM 15842 O TYR B 459 44.354 35.630 −41.171 1.00 15.37 B O ATOM 15844 N MET B 460 45.209 33.646 −41.798 1.00 16.17 B N ATOM 15845 CA MET B 460 45.137 33.935 −43.234 1.00 17.10 B C ATOM 15847 CB MET B 460 45.871 32.865 −44.049 1.00 17.68 B C ATOM 15850 CG MET B 460 47.381 33.004 −44.070 1.00 20.00 B C ATOM 15853 SD MET B 460 48.194 31.536 −44.746 1.00 24.41 B S ATOM 15854 CE MET B 460 47.441 31.432 −46.371 1.00 21.79 B C ATOM 15858 C MET B 460 43.690 34.021 −43.726 1.00 17.18 B C ATOM 15859 O MET B 460 43.328 34.962 −44.434 1.00 17.43 B O ATOM 15861 N ARG B 461 42.877 33.031 −43.359 1.00 17.00 B N ATOM 15862 CA ARG B 461 41.472 32.966 −43.784 1.00 16.70 B C ATOM 15864 CB ARG B 461 40.848 31.623 −43.399 1.00 16.92 B C ATOM 15867 CG ARG B 461 41.012 30.525 −44.433 1.00 17.73 B C ATOM 15870 CD ARG B 461 40.488 29.211 −43.879 1.00 19.18 B C ATOM 15873 NE ARG B 461 41.337 28.716 −42.794 1.00 19.69 B N ATOM 15875 CZ ARG B 461 40.942 27.907 −41.810 1.00 20.75 B C ATOM 15876 NH1 ARG B 461 39.687 27.474 −41.729 1.00 20.89 B N ATOM 15879 NH2 ARG B 461 41.819 27.534 −40.886 1.00 22.40 B N ATOM 15882 C ARG B 461 40.621 34.079 −43.186 1.00 16.22 B C ATOM 15883 O ARG B 461 39.803 34.683 −43.879 1.00 16.34 B O ATOM 15885 N THR B 462 40.807 34.330 −41.895 1.00 15.74 B N ATOM 15886 CA THR B 462 40.008 35.317 −41.181 1.00 15.73 B C ATOM 15888 CB THR B 462 40.255 35.228 −39.672 1.00 15.53 B C ATOM 15890 OG1 THR B 462 39.962 33.900 −39.224 1.00 15.96 B O ATOM 15892 CG2 THR B 462 39.379 36.217 −38.924 1.00 16.51 B C ATOM 15896 C THR B 462 40.261 36.749 −41.649 1.00 15.94 B C ATOM 15897 O THR B 462 39.322 37.532 −41.801 1.00 16.24 B O ATOM 15899 N LYS B 463 41.527 37.084 −41.876 1.00 15.98 B N ATOM 15900 CA LYS B 463 41.906 38.423 −42.316 1.00 16.21 B C ATOM 15902 CB LYS B 463 43.232 38.827 −41.672 1.00 16.41 B C ATOM 15905 CG LYS B 463 43.165 38.978 −40.152 1.00 16.93 B C ATOM 15908 CD LYS B 463 42.539 40.306 −39.738 1.00 16.56 B C ATOM 15911 CE LYS B 463 42.716 40.567 −38.251 1.00 16.16 B C ATOM 15914 NZ LYS B 463 42.453 41.992 −37.910 1.00 15.98 B N ATOM 15918 C LYS B 463 42.010 38.525 −43.838 1.00 16.35 B C ATOM 15919 O LYS B 463 42.119 39.628 −44.379 1.00 16.35 B O ATOM 15921 N GLY B 464 41.977 37.381 −44.520 1.00 16.54 B N ATOM 15922 CA GLY B 464 42.063 37.340 −45.978 1.00 16.78 B C ATOM 15925 C GLY B 464 43.348 37.955 −46.500 1.00 17.14 B C ATOM 15926 O GLY B 464 43.316 38.779 −47.415 1.00 17.35 B O ATOM 15928 N ILE B 465 44.477 37.550 −45.917 1.00 17.39 B N ATOM 15929 CA ILE B 465 45.789 38.112 −46.265 1.00 17.68 B C ATOM 15931 CB ILE B 465 46.356 39.000 −45.122 1.00 17.52 B C ATOM 15933 CG1 ILE B 465 46.503 38.208 −43.818 1.00 16.22 B C ATOM 15936 CD1 ILE B 465 47.122 39.001 −42.698 1.00 13.96 B C ATOM 15940 CG2 ILE B 465 45.457 40.206 −44.901 1.00 18.60 B C ATOM 15944 C ILE B 465 46.802 37.022 −46.626 1.00 18.16 B C ATOM 15945 O ILE B 465 46.529 35.831 −46.464 1.00 18.09 B O ATOM 15947 N SER B 466 47.966 37.448 −47.118 1.00 18.79 B N ATOM 15948 CA SER B 466 49.035 36.535 −47.538 1.00 19.13 B C ATOM 15950 CB SER B 466 50.103 37.303 −48.318 1.00 19.18 B C ATOM 15953 OG SER B 466 50.799 38.203 −47.471 1.00 18.23 B O ATOM 15955 C SER B 466 49.694 35.843 −46.349 1.00 19.60 B C ATOM 15956 O SER B 466 49.741 36.401 −45.251 1.00 19.64 B O ATOM 15958 N GLU B 467 50.216 34.637 −46.581 1.00 20.01 B N ATOM 15959 CA GLU B 467 50.903 33.862 −45.535 1.00 20.44 B C ATOM 15961 CB GLU B 467 51.440 32.541 −46.106 1.00 20.58 B C ATOM 15964 CG GLU B 467 52.180 31.664 −45.086 1.00 20.96 B C ATOM 15967 CD GLU B 467 52.735 30.383 −45.685 1.00 21.70 B C ATOM 15968 OE1 GLU B 467 52.053 29.765 −46.530 1.00 22.54 B O ATOM 15969 OE2 GLU B 467 53.854 29.984 −45.296 1.00 22.39 B O ATOM 15970 C GLU B 467 52.047 34.650 −44.895 1.00 20.53 B C ATOM 15971 O GLU B 467 52.293 34.541 −43.692 1.00 20.25 B O ATOM 15973 N GLU B 468 52.744 35.432 −45.714 1.00 20.89 B N ATOM 15974 CA GLU B 468 53.826 36.295 −45.253 1.00 21.16 B C ATOM 15976 CB GLU B 468 54.438 37.025 −46.451 1.00 21.39 B C ATOM 15979 CG GLU B 468 55.709 37.807 −46.150 1.00 22.77 B C ATOM 15982 CD GLU B 468 56.147 38.680 −47.317 1.00 25.04 B C ATOM 15983 OE1 GLU B 468 55.474 38.657 −48.373 1.00 26.20 B O ATOM 15984 OE2 GLU B 468 57.164 39.393 −47.179 1.00 26.28 B O ATOM 15985 C GLU B 468 53.330 37.316 −44.225 1.00 20.91 B C ATOM 15986 O GLU B 468 53.981 37.540 −43.203 1.00 21.14 B O ATOM 15988 N LEU B 469 52.179 37.925 −44.507 1.00 20.46 B N ATOM 15989 CA LEU B 469 51.607 38.964 −43.642 1.00 19.85 B C ATOM 15991 CB LEU B 469 50.616 39.833 −44.433 1.00 19.93 B C ATOM 15994 CG LEU B 469 50.541 41.325 −44.088 1.00 19.46 B C ATOM 15996 CD1 LEU B 469 49.630 42.035 −45.081 1.00 19.01 B C ATOM 16000 CD2 LEU B 469 50.071 41.572 −42.657 1.00 18.30 B C ATOM 16004 C LEU B 469 50.923 38.353 −42.412 1.00 19.10 B C ATOM 16005 O LEU B 469 50.888 38.969 −41.349 1.00 18.73 B O ATOM 16007 N ALA B 470 50.374 37.149 −42.565 1.00 18.69 B N ATOM 16008 CA ALA B 470 49.770 36.427 −41.443 1.00 18.30 B C ATOM 16010 CB ALA B 470 48.984 35.221 −41.945 1.00 18.19 B C ATOM 16014 C ALA B 470 50.835 35.987 −40.441 1.00 17.77 B C ATOM 16015 O ALA B 470 50.624 36.070 −39.230 1.00 17.14 B O ATOM 16017 N THR B 471 51.970 35.517 −40.961 1.00 17.77 B N ATOM 16018 CA THR B 471 53.128 35.137 −40.141 1.00 17.92 B C ATOM 16020 CB THR B 471 54.264 34.553 −41.009 1.00 17.78 B C ATOM 16022 OG1 THR B 471 53.940 33.208 −41.381 1.00 18.24 B O ATOM 16024 CG2 THR B 471 55.586 34.559 −40.261 1.00 17.26 B C ATOM 16028 C THR B 471 53.670 36.319 −39.337 1.00 18.26 B C ATOM 16029 O THR B 471 54.011 36.171 −38.164 1.00 18.51 B O ATOM 16031 N GLU B 472 53.747 37.483 −39.979 1.00 18.50 B N ATOM 16032 CA GLU B 472 54.144 38.730 −39.322 1.00 18.54 B C ATOM 16034 CB GLU B 472 54.078 39.882 −40.333 1.00 18.66 B C ATOM 16037 CG GLU B 472 54.483 41.252 −39.797 1.00 19.75 B C ATOM 16040 CD GLU B 472 54.306 42.361 −40.825 1.00 20.71 B C ATOM 16041 OE1 GLU B 472 53.611 42.146 −41.843 1.00 18.97 B O ATOM 16042 OE2 GLU B 472 54.864 43.457 −40.610 1.00 22.53 B O ATOM 16043 C GLU B 472 53.255 39.043 −38.112 1.00 18.37 B C ATOM 16044 O GLU B 472 53.753 39.376 −37.036 1.00 18.21 B O ATOM 16046 N SER B 473 51.941 38.931 −38.299 1.00 18.41 B N ATOM 16047 CA SER B 473 50.970 39.247 −37.248 1.00 18.17 B C ATOM 16049 CB SER B 473 49.548 39.246 −37.813 1.00 17.98 B C ATOM 16052 OG SER B 473 49.382 40.280 −38.766 1.00 17.49 B O ATOM 16054 C SER B 473 51.058 38.289 −36.061 1.00 18.17 B C ATOM 16055 O SER B 473 50.892 38.704 −34.913 1.00 18.49 B O ATOM 16057 N VAL B 474 51.314 37.013 −36.339 1.00 17.87 B N ATOM 16058 CA VAL B 474 51.508 36.026 −35.278 1.00 17.81 B C ATOM 16060 CB VAL B 474 51.578 34.583 −35.835 1.00 17.80 B C ATOM 16062 CG1 VAL B 474 51.912 33.591 −34.727 1.00 16.61 B C ATOM 16066 CG2 VAL B 474 50.261 34.205 −36.504 1.00 16.90 B C ATOM 16070 C VAL B 474 52.769 36.341 −34.469 1.00 18.13 B C ATOM 16071 O VAL B 474 52.783 36.165 −33.253 1.00 18.18 B O ATOM 16073 N MET B 475 53.817 36.817 −35.139 1.00 18.76 B N ATOM 16074 CA MET B 475 55.033 37.248 −34.443 1.00 19.47 B C ATOM 16076 CB MET B 475 56.131 37.658 −35.433 1.00 19.73 B C ATOM 16079 CG MET B 475 56.654 36.537 −36.319 1.00 20.45 B C ATOM 16082 SD MET B 475 57.699 35.349 −35.460 1.00 23.17 B S ATOM 16083 CE MET B 475 58.311 34.392 −36.849 1.00 21.35 B C ATOM 16087 C MET B 475 54.718 38.423 −33.517 1.00 19.81 B C ATOM 16088 O MET B 475 55.195 38.471 −32.383 1.00 19.66 B O ATOM 16090 N ASN B 476 53.912 39.363 −34.009 1.00 20.14 B N ATOM 16091 CA ASN B 476 53.483 40.518 −33.216 1.00 20.47 B C ATOM 16093 CB ASN B 476 52.766 41.543 −34.102 1.00 20.65 B C ATOM 16096 CG ASN B 476 53.699 42.205 −35.101 1.00 21.93 B C ATOM 16097 OD1 ASN B 476 54.734 42.757 −34.726 1.00 24.56 B O ATOM 16098 ND2 ASN B 476 53.333 42.160 −36.379 1.00 22.45 B N ATOM 16101 C ASN B 476 52.581 40.123 −32.044 1.00 20.49 B C ATOM 16102 O ASN B 476 52.541 40.815 −31.025 1.00 20.89 B O ATOM 16104 N LEU B 477 51.862 39.014 −32.195 1.00 20.27 B N ATOM 16105 CA LEU B 477 51.019 38.481 −31.123 1.00 19.90 B C ATOM 16107 CB LEU B 477 50.030 37.446 −31.674 1.00 19.84 B C ATOM 16110 CG LEU B 477 48.636 37.462 −31.046 1.00 19.42 B C ATOM 16112 CD1 LEU B 477 47.908 38.751 −31.411 1.00 18.74 B C ATOM 16116 CD2 LEU B 477 47.841 36.247 −31.494 1.00 18.32 B C ATOM 16120 C LEU B 477 51.877 37.863 −30.013 1.00 19.60 B C ATOM 16121 O LEU B 477 51.480 37.864 −28.845 1.00 19.36 B O ATOM 16123 N ILE B 478 53.045 37.335 −30.386 1.00 19.33 B N ATOM 16124 CA ILE B 478 54.028 36.846 −29.414 1.00 18.77 B C ATOM 16126 CB ILE B 478 55.159 36.038 −30.092 1.00 18.25 B C ATOM 16128 CG1 ILE B 478 54.626 34.686 −30.568 1.00 17.56 B C ATOM 16131 CD1 ILE B 478 55.694 33.767 −31.126 1.00 17.90 B C ATOM 16135 CG2 ILE B 478 56.321 35.832 −29.135 1.00 16.88 B C ATOM 16139 C ILE B 478 54.631 38.007 −28.622 1.00 19.04 B C ATOM 16140 O ILE B 478 54.677 37.962 −27.393 1.00 19.14 B O ATOM 16142 N ASP B 479 55.088 39.040 −29.331 1.00 19.19 B N ATOM 16143 CA ASP B 479 55.605 40.255 −28.694 1.00 19.30 B C ATOM 16145 CB ASP B 479 55.884 41.345 −29.739 1.00 19.38 B C ATOM 16148 CG ASP B 479 57.121 41.061 −30.580 1.00 19.94 B C ATOM 16149 OD1 ASP B 479 57.589 39.903 −30.603 1.00 22.59 B O ATOM 16150 OD2 ASP B 479 57.625 42.004 −31.228 1.00 19.87 B O ATOM 16151 C ASP B 479 54.625 40.792 −27.649 1.00 19.52 B C ATOM 16152 O ASP B 479 55.007 41.051 −26.506 1.00 19.57 B O ATOM 16154 N GLU B 480 53.362 40.940 −28.044 1.00 19.62 B N ATOM 16155 CA GLU B 480 52.332 41.489 −27.156 1.00 19.69 B C ATOM 16157 CB GLU B 480 51.053 41.813 −27.939 1.00 19.64 B C ATOM 16160 CG GLU B 480 51.154 43.076 −28.785 1.00 20.42 B C ATOM 16163 CD GLU B 480 51.566 44.302 −27.976 1.00 21.42 B C ATOM 16164 OE1 GLU B 480 52.363 45.113 −28.490 1.00 21.49 B O ATOM 16165 OE2 GLU B 480 51.104 44.448 −26.823 1.00 21.89 B O ATOM 16166 C GLU B 480 52.004 40.588 −25.966 1.00 19.49 B C ATOM 16167 O GLU B 480 51.663 41.085 −24.889 1.00 19.09 B O ATOM 16169 N THR B 481 52.102 39.274 −26.165 1.00 19.48 B N ATOM 16170 CA THR B 481 51.921 38.308 −25.077 1.00 19.19 B C ATOM 16172 CB THR B 481 51.751 36.871 −25.609 1.00 18.82 B C ATOM 16174 OG1 THR B 481 50.430 36.713 −26.142 1.00 17.25 B O ATOM 16176 CG2 THR B 481 51.964 35.856 −24.497 1.00 18.35 B C ATOM 16180 C THR B 481 53.093 38.359 −24.092 1.00 19.61 B C ATOM 16181 O THR B 481 52.883 38.329 −22.877 1.00 20.16 B O ATOM 16183 N TRP B 482 54.318 38.438 −24.613 1.00 19.27 B N ATOM 16184 CA TRP B 482 55.503 38.600 −23.763 1.00 19.03 B C ATOM 16186 CB TRP B 482 56.805 38.542 −24.581 1.00 19.10 B C ATOM 16189 CG TRP B 482 57.389 37.164 −24.652 1.00 19.78 B C ATOM 16190 CD1 TRP B 482 57.235 36.257 −25.660 1.00 20.32 B C ATOM 16192 NE1 TRP B 482 57.906 35.097 −25.360 1.00 20.19 B N ATOM 16194 CE2 TRP B 482 58.509 35.235 −24.137 1.00 20.96 B C ATOM 16195 CD2 TRP B 482 58.203 36.526 −23.660 1.00 20.92 B C ATOM 16196 CE3 TRP B 482 58.704 36.921 −22.413 1.00 20.54 B C ATOM 16198 CZ3 TRP B 482 59.485 36.024 −21.694 1.00 19.83 B C ATOM 16200 CH2 TRP B 482 59.775 34.750 −22.197 1.00 18.86 B C ATOM 16202 CZ2 TRP B 482 59.300 34.336 −23.413 1.00 19.97 B C ATOM 16204 C TRP B 482 55.439 39.896 −22.960 1.00 18.96 B C ATOM 16205 O TRP B 482 55.892 39.935 −21.818 1.00 18.99 B O ATOM 16207 N LYS B 483 54.871 40.945 −23.553 1.00 18.84 B N ATOM 16208 CA LYS B 483 54.711 42.228 −22.860 1.00 18.72 B C ATOM 16210 CB LYS B 483 54.188 43.306 −23.818 1.00 18.58 B C ATOM 16213 CG LYS B 483 55.251 43.895 −24.728 1.00 16.71 B C ATOM 16216 CD LYS B 483 54.670 44.960 −25.639 1.00 14.83 B C ATOM 16219 CE LYS B 483 55.692 45.441 −26.649 1.00 13.58 B C ATOM 16222 NZ LYS B 483 55.245 46.679 −27.324 1.00 11.34 B N ATOM 16226 C LYS B 483 53.790 42.123 −21.640 1.00 18.92 B C ATOM 16227 O LYS B 483 53.982 42.829 −20.648 1.00 19.09 B O ATOM 16229 N LYS B 484 52.799 41.241 −21.717 1.00 18.99 B N ATOM 16230 CA LYS B 484 51.861 41.039 −20.615 1.00 19.49 B C ATOM 16232 CB LYS B 484 50.477 40.674 −21.160 1.00 19.74 B C ATOM 16235 CG LYS B 484 49.839 41.803 −21.979 1.00 20.77 B C ATOM 16238 CD LYS B 484 48.609 41.336 −22.749 1.00 21.69 B C ATOM 16241 CE LYS B 484 48.153 42.369 −23.775 1.00 21.40 B C ATOM 16244 NZ LYS B 484 47.244 41.774 −24.798 1.00 21.11 B N ATOM 16248 C LYS B 484 52.368 39.992 −19.614 1.00 19.34 B C ATOM 16249 O LYS B 484 52.050 40.061 −18.427 1.00 19.45 B O ATOM 16251 N MET B 485 53.157 39.031 −20.089 1.00 19.18 B N ATOM 16252 CA MET B 485 53.822 38.075 −19.199 1.00 19.15 B C ATOM 16254 CB MET B 485 54.469 36.941 −19.992 1.00 18.98 B C ATOM 16257 CG MET B 485 53.499 35.902 −20.500 1.00 18.28 B C ATOM 16260 SD MET B 485 54.363 34.436 −21.072 1.00 16.65 B S ATOM 16261 CE MET B 485 55.425 35.132 −22.337 1.00 16.32 B C ATOM 16265 C MET B 485 54.897 38.750 −18.353 1.00 19.51 B C ATOM 16266 O MET B 485 55.082 38.397 −17.190 1.00 19.86 B O ATOM 16268 N ASN B 486 55.615 39.700 −18.949 1.00 19.82 B N ATOM 16269 CA ASN B 486 56.642 40.457 −18.234 1.00 20.17 B C ATOM 16271 CB ASN B 486 57.353 41.434 −19.175 1.00 20.23 B C ATOM 16274 CG ASN B 486 58.260 40.739 −20.174 1.00 20.22 B C ATOM 16275 OD1 ASN B 486 58.679 39.597 −19.968 1.00 18.04 B O ATOM 16276 ND2 ASN B 486 58.570 41.432 −21.267 1.00 18.35 B N ATOM 16279 C ASN B 486 56.073 41.225 −17.046 1.00 20.79 B C ATOM 16280 O ASN B 486 56.712 41.302 −15.994 1.00 20.97 B O ATOM 16282 N LYS B 487 54.878 41.792 −17.221 1.00 21.29 B N ATOM 16283 CA LYS B 487 54.199 42.524 −16.147 1.00 21.50 B C ATOM 16285 CB LYS B 487 52.967 43.266 −16.678 1.00 21.48 B C ATOM 16288 CG LYS B 487 52.281 44.137 −15.630 1.00 22.59 B C ATOM 16291 CD LYS B 487 51.063 44.853 −16.184 1.00 25.14 B C ATOM 16294 CE LYS B 487 50.218 45.453 −15.064 1.00 26.24 B C ATOM 16297 NZ LYS B 487 48.974 46.098 −15.571 1.00 27.02 B N ATOM 16301 C LYS B 487 53.789 41.596 −15.005 1.00 21.42 B C ATOM 16302 O LYS B 487 53.830 41.990 −13.841 1.00 21.42 B O ATOM 16304 N GLU B 488 53.397 40.371 −15.346 1.00 21.59 B N ATOM 16305 CA GLU B 488 52.999 39.373 −14.350 1.00 21.83 B C ATOM 16307 CB GLU B 488 52.583 38.064 −15.035 1.00 21.81 B C ATOM 16310 CG GLU B 488 51.557 37.253 −14.256 1.00 21.26 B C ATOM 16313 CD GLU B 488 50.179 37.886 −14.273 1.00 19.11 B C ATOM 16314 OE1 GLU B 488 49.566 38.007 −13.191 1.00 20.01 B O ATOM 16315 OE2 GLU B 488 49.713 38.270 −15.365 1.00 14.89 B O ATOM 16316 C GLU B 488 54.134 39.104 −13.359 1.00 22.01 B C ATOM 16317 O GLU B 488 53.948 39.212 −12.145 1.00 22.27 B O ATOM 16319 N LYS B 489 55.308 38.772 −13.894 1.00 21.89 B N ATOM 16320 CA LYS B 489 56.502 38.503 −13.087 1.00 21.65 B C ATOM 16322 CB LYS B 489 57.658 38.066 −13.995 1.00 21.41 B C ATOM 16325 CG LYS B 489 58.974 37.757 −13.282 1.00 20.79 B C ATOM 16328 CD LYS B 489 58.858 36.558 −12.349 1.00 19.77 B C ATOM 16331 CE LYS B 489 60.160 36.303 −11.605 1.00 19.39 B C ATOM 16334 NZ LYS B 489 61.314 36.125 −12.527 1.00 18.60 B N ATOM 16338 C LYS B 489 56.932 39.715 −12.260 1.00 21.80 B C ATOM 16339 O LYS B 489 57.425 39.566 −11.140 1.00 21.96 B O ATOM 16341 N LEU B 490 56.749 40.908 −12.820 1.00 21.81 B N ATOM 16342 CA LEU B 490 57.145 42.143 −12.149 1.00 21.84 B C ATOM 16344 CB LEU B 490 56.972 43.349 −13.084 1.00 21.72 B C ATOM 16347 CG LEU B 490 58.111 44.369 −13.049 1.00 21.17 B C ATOM 16349 CD1 LEU B 490 59.318 43.812 −13.782 1.00 20.00 B C ATOM 16353 CD2 LEU B 490 57.681 45.699 −13.651 1.00 20.57 B C ATOM 16357 C LEU B 490 56.322 42.338 −10.878 1.00 22.21 B C ATOM 16358 O LEU B 490 56.868 42.627 −9.812 1.00 22.30 B O ATOM 16360 N GLY B 491 55.009 42.163 −11.001 1.00 22.57 B N ATOM 16361 CA GLY B 491 54.092 42.349 −9.881 1.00 22.97 B C ATOM 16364 C GLY B 491 52.644 42.326 −10.332 1.00 23.45 B C ATOM 16365 O GLY B 491 52.356 42.365 −11.528 1.00 23.60 B O ATOM 16367 N GLY B 492 51.727 42.281 −9.372 1.00 23.88 B N ATOM 16368 CA GLY B 492 50.315 42.067 −9.672 1.00 24.35 B C ATOM 16371 C GLY B 492 50.083 40.618 −10.053 1.00 24.84 B C ATOM 16372 O GLY B 492 49.210 40.308 −10.867 1.00 24.78 B O ATOM 16374 N SER B 493 50.882 39.734 −9.456 1.00 25.52 B N ATOM 16375 CA SER B 493 50.805 38.298 −9.698 1.00 25.67 B C ATOM 16377 CB SER B 493 52.214 37.695 −9.775 1.00 25.87 B C ATOM 16380 OG SER B 493 53.048 38.173 −8.728 1.00 24.83 B O ATOM 16382 C SER B 493 50.030 37.628 −8.569 1.00 25.46 B C ATOM 16383 O SER B 493 50.479 37.651 −7.421 1.00 25.26 B O ATOM 16385 N PRO B 494 48.869 37.023 −8.886 1.00 25.33 B N ATOM 16386 CA PRO B 494 48.148 36.286 −7.852 1.00 25.35 B C ATOM 16388 CB PRO B 494 46.819 35.943 −8.526 1.00 25.40 B C ATOM 16391 CG PRO B 494 47.149 35.847 −9.962 1.00 25.73 B C ATOM 16394 CD PRO B 494 48.261 36.834 −10.216 1.00 25.52 B C ATOM 16397 C PRO B 494 48.903 35.017 −7.446 1.00 25.19 B C ATOM 16398 O PRO B 494 48.708 34.513 −6.337 1.00 25.71 B O ATOM 16399 N PHE B 495 49.754 34.518 −8.345 1.00 24.45 B N ATOM 16400 CA PHE B 495 50.663 33.413 −8.048 1.00 23.68 B C ATOM 16402 CB PHE B 495 50.894 32.569 −9.303 1.00 23.86 B C ATOM 16405 CG PHE B 495 49.660 31.879 −9.802 1.00 23.56 B C ATOM 16406 CD1 PHE B 495 49.294 30.640 −9.296 1.00 23.17 B C ATOM 16408 CE1 PHE B 495 48.154 29.998 −9.745 1.00 22.12 B C ATOM 16410 CZ PHE B 495 47.361 30.592 −10.713 1.00 21.69 B C ATOM 16412 CE2 PHE B 495 47.715 31.829 −11.227 1.00 22.40 B C ATOM 16414 CD2 PHE B 495 48.860 32.466 −10.770 1.00 22.45 B C ATOM 16416 C PHE B 495 52.005 33.919 −7.523 1.00 22.88 B C ATOM 16417 O PHE B 495 52.295 35.118 −7.564 1.00 22.31 B O ATOM 16419 N ALA B 496 52.816 32.988 −7.031 1.00 22.48 B N ATOM 16420 CA ALA B 496 54.155 33.297 −6.542 1.00 22.48 B C ATOM 16422 CB ALA B 496 54.680 32.144 −5.697 1.00 22.42 B C ATOM 16426 C ALA B 496 55.093 33.563 −7.716 1.00 22.53 B C ATOM 16427 O ALA B 496 54.948 32.954 −8.778 1.00 22.92 B O ATOM 16429 N LYS B 497 56.056 34.463 −7.521 1.00 22.29 B N ATOM 16430 CA LYS B 497 57.052 34.778 −8.557 1.00 21.94 B C ATOM 16432 CB LYS B 497 58.007 35.884 −8.084 1.00 22.07 B C ATOM 16435 CG LYS B 497 57.334 37.237 −7.920 1.00 23.65 B C ATOM 16438 CD LYS B 497 58.343 38.366 −7.815 1.00 24.78 B C ATOM 16441 CE LYS B 497 57.645 39.702 −7.616 1.00 25.70 B C ATOM 16444 NZ LYS B 497 58.598 40.846 −7.649 1.00 26.30 B N ATOM 16448 C LYS B 497 57.849 33.552 −9.035 1.00 21.17 B C ATOM 16449 O LYS B 497 58.182 33.465 −10.220 1.00 20.85 B O ATOM 16451 N PRO B 498 58.169 32.613 −8.120 1.00 20.40 B N ATOM 16452 CA PRO B 498 58.746 31.335 −8.539 1.00 19.76 B C ATOM 16454 CB PRO B 498 58.843 30.555 −7.228 1.00 20.02 B C ATOM 16457 CG PRO B 498 59.067 31.596 −6.208 1.00 20.28 B C ATOM 16460 CD PRO B 498 58.282 32.797 −6.659 1.00 20.41 B C ATOM 16463 C PRO B 498 57.892 30.572 −9.551 1.00 19.04 B C ATOM 16464 O PRO B 498 58.429 30.080 −10.543 1.00 18.97 B O ATOM 16465 N PHE B 499 56.584 30.478 −9.308 1.00 18.00 B N ATOM 16466 CA PHE B 499 55.679 29.806 −10.247 1.00 17.28 B C ATOM 16468 CB PHE B 499 54.339 29.476 −9.595 1.00 17.32 B C ATOM 16471 CG PHE B 499 53.370 28.806 −10.530 1.00 17.69 B C ATOM 16472 CD1 PHE B 499 53.589 27.497 −10.951 1.00 17.29 B C ATOM 16474 CE1 PHE B 499 52.705 26.871 −11.823 1.00 16.85 B C ATOM 16476 CZ PHE B 499 51.587 27.557 −12.288 1.00 16.84 B C ATOM 16478 CE2 PHE B 499 51.362 28.868 −11.880 1.00 17.65 B C ATOM 16480 CD2 PHE B 499 52.252 29.486 −11.006 1.00 17.32 B C ATOM 16482 C PHE B 499 55.432 30.634 −11.505 1.00 16.84 B C ATOM 16483 O PHE B 499 55.363 30.086 −12.605 1.00 16.87 B O ATOM 16485 N VAL B 500 55.287 31.947 −11.338 1.00 16.41 B N ATOM 16486 CA VAL B 500 55.142 32.861 −12.474 1.00 16.20 B C ATOM 16488 CB VAL B 500 54.925 34.317 −12.010 1.00 16.36 B C ATOM 16490 CG1 VAL B 500 53.606 34.442 −11.264 1.00 17.18 B C ATOM 16494 CG2 VAL B 500 54.957 35.280 −13.191 1.00 16.91 B C ATOM 16498 C VAL B 500 56.363 32.793 −13.394 1.00 15.82 B C ATOM 16499 O VAL B 500 56.243 32.992 −14.600 1.00 15.97 B O ATOM 16501 N GLU B 501 57.531 32.509 −12.822 1.00 15.50 B N ATOM 16502 CA GLU B 501 58.734 32.258 −13.615 1.00 15.59 B C ATOM 16504 CB GLU B 501 60.003 32.453 −12.769 1.00 15.69 B C ATOM 16507 CG GLU B 501 61.332 32.376 −13.545 1.00 15.01 B C ATOM 16510 CD GLU B 501 61.554 33.531 −14.526 1.00 16.71 B C ATOM 16511 OE1 GLU B 501 60.739 34.482 −14.571 1.00 14.60 B O ATOM 16512 OE2 GLU B 501 62.564 33.485 −15.261 1.00 18.19 B O ATOM 16513 C GLU B 501 58.704 30.854 −14.231 1.00 15.47 B C ATOM 16514 O GLU B 501 59.123 30.677 −15.375 1.00 16.14 B O ATOM 16516 N THR B 502 58.217 29.862 −13.484 1.00 14.76 B N ATOM 16517 CA THR B 502 58.104 28.497 −14.010 1.00 14.28 B C ATOM 16519 CB THR B 502 57.531 27.499 −12.973 1.00 14.03 B C ATOM 16521 OG1 THR B 502 58.190 27.660 −11.715 1.00 13.78 B O ATOM 16523 CG2 THR B 502 57.721 26.070 −13.449 1.00 12.78 B C ATOM 16527 C THR B 502 57.210 28.464 −15.246 1.00 14.49 B C ATOM 16528 O THR B 502 57.505 27.760 −16.207 1.00 14.67 B O ATOM 16530 N ALA B 503 56.119 29.227 −15.215 1.00 14.64 B N ATOM 16531 CA ALA B 503 55.206 29.306 −16.354 1.00 14.82 B C ATOM 16533 CB ALA B 503 53.932 30.048 −15.973 1.00 14.76 B C ATOM 16537 C ALA B 503 55.890 29.989 −17.534 1.00 14.83 B C ATOM 16538 O ALA B 503 55.970 29.425 −18.623 1.00 14.59 B O ATOM 16540 N ILE B 504 56.404 31.194 −17.307 1.00 14.79 B N ATOM 16541 CA ILE B 504 57.111 31.936 −18.350 1.00 15.23 B C ATOM 16543 CB ILE B 504 57.747 33.233 −17.790 1.00 15.36 B C ATOM 16545 CG1 ILE B 504 56.654 34.265 −17.483 1.00 15.16 B C ATOM 16548 CD1 ILE B 504 57.127 35.440 −16.656 1.00 12.30 B C ATOM 16552 CG2 ILE B 504 58.740 33.834 −18.782 1.00 15.13 B C ATOM 16556 C ILE B 504 58.174 31.065 −19.032 1.00 15.91 B C ATOM 16557 O ILE B 504 58.417 31.207 −20.231 1.00 16.25 B O ATOM 16559 N ASN B 505 58.787 30.155 −18.273 1.00 16.36 B N ATOM 16560 CA ASN B 505 59.760 29.208 −18.829 1.00 16.52 B C ATOM 16562 CB ASN B 505 60.447 28.408 −17.710 1.00 16.46 B C ATOM 16565 CG ASN B 505 61.425 29.249 −16.892 1.00 16.04 B C ATOM 16566 OD1 ASN B 505 62.149 30.091 −17.427 1.00 13.66 B O ATOM 16567 ND2 ASN B 505 61.456 29.008 −15.586 1.00 16.62 B N ATOM 16570 C ASN B 505 59.169 28.251 −19.876 1.00 16.61 B C ATOM 16571 O ASN B 505 59.891 27.786 −20.761 1.00 16.48 B O ATOM 16573 N LEU B 506 57.872 27.955 −19.774 1.00 16.86 B N ATOM 16574 CA LEU B 506 57.171 27.184 −20.810 1.00 17.30 B C ATOM 16576 CB LEU B 506 55.726 26.888 −20.401 1.00 17.57 B C ATOM 16579 CG LEU B 506 54.836 26.191 −21.440 1.00 18.47 B C ATOM 16581 CD1 LEU B 506 55.184 24.719 −21.542 1.00 19.77 B C ATOM 16585 CD2 LEU B 506 53.370 26.364 −21.073 1.00 20.68 B C ATOM 16589 C LEU B 506 57.177 27.946 −22.130 1.00 17.50 B C ATOM 16590 O LEU B 506 57.340 27.351 −23.195 1.00 17.72 B O ATOM 16592 N ALA B 507 56.985 29.261 −22.054 1.00 17.77 B N ATOM 16593 CA ALA B 507 57.067 30.120 −23.233 1.00 17.80 B C ATOM 16595 CB ALA B 507 56.635 31.536 −22.893 1.00 17.84 B C ATOM 16599 C ALA B 507 58.483 30.117 −23.796 1.00 17.61 B C ATOM 16600 O ALA B 507 58.671 29.989 −25.003 1.00 17.76 B O ATOM 16602 N ARG B 508 59.472 30.246 −22.913 1.00 17.60 B N ATOM 16603 CA ARG B 508 60.880 30.193 −23.309 1.00 17.71 B C ATOM 16605 CB ARG B 508 61.803 30.386 −22.100 1.00 17.79 B C ATOM 16608 CG ARG B 508 61.746 31.773 −21.487 1.00 18.73 B C ATOM 16611 CD ARG B 508 62.939 32.043 −20.582 1.00 19.55 B C ATOM 16614 NE ARG B 508 62.905 33.398 −20.024 1.00 19.83 B N ATOM 16616 CZ ARG B 508 62.358 33.739 −18.857 1.00 19.59 B C ATOM 16617 NH1 ARG B 508 61.781 32.831 −18.073 1.00 19.68 B N ATOM 16620 NH2 ARG B 508 62.391 35.009 −18.468 1.00 19.69 B N ATOM 16623 C ARG B 508 61.212 28.870 −23.984 1.00 17.74 B C ATOM 16624 O ARG B 508 61.822 28.855 −25.052 1.00 17.57 B O ATOM 16626 N GLN B 509 60.806 27.767 −23.355 1.00 17.87 B N ATOM 16627 CA GLN B 509 61.065 26.428 −23.889 1.00 18.05 B C ATOM 16629 CB GLN B 509 60.600 25.353 −22.901 1.00 17.84 B C ATOM 16632 CG GLN B 509 60.772 23.904 −23.383 1.00 17.66 B C ATOM 16635 CD GLN B 509 62.217 23.521 −23.658 1.00 16.78 B C ATOM 16636 OE1 GLN B 509 63.150 24.156 −23.170 1.00 17.45 B O ATOM 16637 NE2 GLN B 509 62.404 22.471 −24.442 1.00 16.89 B N ATOM 16640 C GLN B 509 60.396 26.220 −25.248 1.00 18.61 B C ATOM 16641 O GLN B 509 60.959 25.561 −26.124 1.00 18.92 B O ATOM 16643 N SER B 510 59.202 26.782 −25.423 1.00 18.83 B N ATOM 16644 CA SER B 510 58.498 26.692 −26.700 1.00 18.95 B C ATOM 16646 CB SER B 510 57.109 27.323 −26.603 1.00 18.82 B C ATOM 16649 OG SER B 510 56.264 26.533 −25.788 1.00 19.00 B O ATOM 16651 C SER B 510 59.292 27.337 −27.832 1.00 19.16 B C ATOM 16652 O SER B 510 59.232 26.882 −28.968 1.00 19.43 B O ATOM 16654 N HIS B 511 60.041 28.390 −27.526 1.00 19.42 B N ATOM 16655 CA HIS B 511 60.889 29.022 −28.531 1.00 20.02 B C ATOM 16657 CB HIS B 511 61.405 30.380 −28.041 1.00 20.11 B C ATOM 16660 CG HIS B 511 60.395 31.479 −28.143 1.00 17.99 B C ATOM 16661 ND1 HIS B 511 60.065 32.074 −29.341 1.00 17.74 B N ATOM 16663 CE1 HIS B 511 59.155 33.006 −29.131 1.00 18.27 B C ATOM 16665 NE2 HIS B 511 58.883 33.038 −27.839 1.00 17.55 B N ATOM 16667 CD2 HIS B 511 59.645 32.092 −27.199 1.00 16.35 B C ATOM 16669 C HIS B 511 62.058 28.118 −28.933 1.00 20.72 B C ATOM 16670 O HIS B 511 62.345 27.955 −30.121 1.00 20.84 B O ATOM 16672 N CYS B 512 62.712 27.519 −27.943 1.00 21.38 B N ATOM 16673 CA CYS B 512 63.904 26.704 −28.187 1.00 22.20 B C ATOM 16675 CB CYS B 512 64.715 26.569 −26.894 1.00 22.42 B C ATOM 16678 SG CYS B 512 65.118 28.158 −26.116 1.00 23.55 B S ATOM 16680 C CYS B 512 63.604 25.313 −28.765 1.00 22.44 B C ATOM 16681 O CYS B 512 64.520 24.628 −29.223 1.00 22.16 B O ATOM 16683 N THR B 513 62.337 24.898 −28.740 1.00 23.12 B N ATOM 16684 CA THR B 513 61.931 23.599 −29.287 1.00 24.06 B C ATOM 16686 CB THR B 513 60.899 22.897 −28.371 1.00 24.30 B C ATOM 16688 OG1 THR B 513 61.262 23.083 −26.999 1.00 25.60 B O ATOM 16690 CG2 THR B 513 60.832 21.401 −28.671 1.00 24.35 B C ATOM 16694 C THR B 513 61.340 23.706 −30.700 1.00 24.58 B C ATOM 16695 O THR B 513 61.194 22.695 −31.386 1.00 24.46 B O ATOM 16697 N TYR B 514 61.003 24.921 −31.132 1.00 25.51 B N ATOM 16698 CA TYR B 514 60.432 25.139 −32.463 1.00 26.21 B C ATOM 16700 CB TYR B 514 58.968 25.573 −32.348 1.00 25.89 B C ATOM 16703 CG TYR B 514 58.098 24.497 −31.729 1.00 24.88 B C ATOM 16704 CD1 TYR B 514 57.783 23.342 −32.437 1.00 25.24 B C ATOM 16706 CE1 TYR B 514 56.994 22.346 −31.874 1.00 24.68 B C ATOM 16708 CZ TYR B 514 56.514 22.499 −30.589 1.00 23.33 B C ATOM 16709 OH TYR B 514 55.733 21.511 −30.037 1.00 24.82 B O ATOM 16711 CE2 TYR B 514 56.816 23.634 −29.863 1.00 22.23 B C ATOM 16713 CD2 TYR B 514 57.606 24.622 −30.432 1.00 23.14 B C ATOM 16715 C TYR B 514 61.268 26.142 −33.264 1.00 27.31 B C ATOM 16716 O TYR B 514 61.143 27.358 −33.107 1.00 27.40 B O ATOM 16718 N HIS B 515 62.124 25.595 −34.122 1.00 28.61 B N ATOM 16719 CA HIS B 515 63.102 26.361 −34.893 1.00 30.06 B C ATOM 16721 CB HIS B 515 64.492 26.228 −34.242 1.00 30.62 B C ATOM 16724 CG HIS B 515 64.870 24.815 −33.904 1.00 32.08 B C ATOM 16725 ND1 HIS B 515 64.776 24.306 −32.626 1.00 31.97 B N ATOM 16727 CE1 HIS B 515 65.159 23.042 −32.629 1.00 32.68 B C ATOM 16729 NE2 HIS B 515 65.492 22.710 −33.863 1.00 34.16 B N ATOM 16731 CD2 HIS B 515 65.320 23.801 −34.681 1.00 33.51 B C ATOM 16733 C HIS B 515 63.106 25.831 −36.333 1.00 30.55 B C ATOM 16734 O HIS B 515 62.201 25.084 −36.717 1.00 30.83 B O ATOM 16736 N ASN B 516 64.098 26.233 −37.129 1.00 30.79 B N ATOM 16737 CA ASN B 516 64.294 25.687 −38.474 1.00 30.94 B C ATOM 16739 CB ASN B 516 63.524 26.513 −39.512 1.00 31.24 B C ATOM 16742 CG ASN B 516 62.034 26.182 −39.546 1.00 32.16 B C ATOM 16743 OD1 ASN B 516 61.642 25.024 −39.703 1.00 31.94 B O ATOM 16744 ND2 ASN B 516 61.198 27.207 −39.410 1.00 33.17 B N ATOM 16747 C ASN B 516 65.774 25.639 −38.839 1.00 30.76 B C ATOM 16748 O ASN B 516 66.617 25.303 −38.007 1.00 30.70 B O ATOM 16750 N THR B 521 72.475 22.115 −40.233 1.00 39.09 B N ATOM 16751 CA THR B 521 71.640 21.708 −39.109 1.00 39.22 B C ATOM 16753 CB THR B 521 71.978 22.514 −37.832 1.00 39.15 B C ATOM 16755 OG1 THR B 521 73.375 22.401 −37.542 1.00 39.43 B O ATOM 16757 CG2 THR B 521 71.181 22.001 −36.647 1.00 38.86 B C ATOM 16761 C THR B 521 70.152 21.875 −39.426 1.00 39.42 B C ATOM 16762 O THR B 521 69.595 22.965 −39.281 1.00 39.63 B O ATOM 16764 N SER B 522 69.519 20.787 −39.860 1.00 39.51 B N ATOM 16765 CA SER B 522 68.067 20.756 −40.065 1.00 39.64 B C ATOM 16767 CB SER B 522 67.675 19.512 −40.881 1.00 39.62 B C ATOM 16770 OG SER B 522 68.247 18.334 −40.340 1.00 39.80 B O ATOM 16772 C SER B 522 67.354 20.780 −38.702 1.00 39.74 B C ATOM 16773 O SER B 522 68.014 20.665 −37.666 1.00 39.55 B O ATOM 16775 N PRO B 523 66.013 20.952 −38.691 1.00 40.10 B N ATOM 16776 CA PRO B 523 65.277 20.965 −37.414 1.00 40.09 B C ATOM 16778 CB PRO B 523 63.811 21.075 −37.849 1.00 40.16 B C ATOM 16781 CG PRO B 523 63.856 21.703 −39.192 1.00 40.42 B C ATOM 16784 CD PRO B 523 65.125 21.234 −39.836 1.00 40.33 B C ATOM 16787 C PRO B 523 65.498 19.703 −36.572 1.00 40.04 B C ATOM 16788 O PRO B 523 65.670 19.800 −35.353 1.00 39.93 B O ATOM 16789 N ASP B 524 65.479 18.538 −37.222 1.00 39.90 B N ATOM 16790 CA ASP B 524 65.886 17.277 −36.593 1.00 39.64 B C ATOM 16792 CB ASP B 524 65.136 16.081 −37.198 1.00 39.95 B C ATOM 16795 CG ASP B 524 63.726 15.926 −36.655 1.00 40.66 B C ATOM 16796 OD1 ASP B 524 63.491 16.229 −35.465 1.00 40.38 B O ATOM 16797 OD2 ASP B 524 62.851 15.477 −37.425 1.00 42.77 B O ATOM 16798 C ASP B 524 67.386 17.083 −36.782 1.00 38.91 B C ATOM 16799 O ASP B 524 67.812 16.471 −37.759 1.00 39.00 B O ATOM 16801 N GLU B 525 68.159 17.608 −35.830 1.00 38.15 B N ATOM 16802 CA GLU B 525 69.642 17.592 −35.810 1.00 37.66 B C ATOM 16804 CB GLU B 525 70.297 17.569 −37.206 1.00 37.71 B C ATOM 16807 CG GLU B 525 70.620 16.153 −37.724 1.00 37.79 B C ATOM 16810 CD GLU B 525 71.981 16.048 −38.386 1.00 38.25 B C ATOM 16811 OE1 GLU B 525 72.955 16.625 −37.857 1.00 39.00 B O ATOM 16812 OE2 GLU B 525 72.080 15.370 −39.430 1.00 38.77 B O ATOM 16813 C GLU B 525 70.191 18.771 −34.994 1.00 36.95 B C ATOM 16814 O GLU B 525 71.317 18.714 −34.499 1.00 37.04 B O ATOM 16816 N LEU B 526 69.407 19.842 −34.880 1.00 36.09 B N ATOM 16817 CA LEU B 526 69.625 20.840 −33.837 1.00 35.33 B C ATOM 16819 CB LEU B 526 68.900 22.150 −34.161 1.00 35.12 B C ATOM 16822 CG LEU B 526 69.334 23.384 −33.364 1.00 34.90 B C ATOM 16824 CD1 LEU B 526 68.442 24.568 −33.694 1.00 34.94 B C ATOM 16828 CD2 LEU B 526 70.793 23.730 −33.630 1.00 36.14 B C ATOM 16832 C LEU B 526 69.105 20.252 −32.527 1.00 34.83 B C ATOM 16833 O LEU B 526 69.770 20.327 −31.496 1.00 34.87 B O ATOM 16835 N THR B 527 67.913 19.660 −32.586 1.00 34.52 B N ATOM 16836 CA THR B 527 67.303 18.996 −31.434 1.00 34.28 B C ATOM 16838 CB THR B 527 65.908 18.433 −31.788 1.00 34.07 B C ATOM 16840 OG1 THR B 527 65.038 19.509 −32.164 1.00 33.57 B O ATOM 16842 CG2 THR B 527 65.306 17.682 −30.606 1.00 33.37 B C ATOM 16846 C THR B 527 68.179 17.857 −30.916 1.00 34.29 B C ATOM 16847 O THR B 527 68.451 17.771 −29.716 1.00 34.38 B O ATOM 16849 N ARG B 528 68.617 16.992 −31.829 1.00 34.09 B N ATOM 16850 CA ARG B 528 69.465 15.850 −31.485 1.00 34.07 B C ATOM 16852 CB ARG B 528 69.933 15.138 −32.760 1.00 34.30 B C ATOM 16855 CG ARG B 528 70.746 13.869 −32.528 1.00 35.25 B C ATOM 16858 CD ARG B 528 71.215 13.264 −33.849 1.00 36.66 B C ATOM 16861 NE ARG B 528 72.244 14.073 −34.513 1.00 37.15 B N ATOM 16863 CZ ARG B 528 73.534 14.113 −34.169 1.00 36.44 B C ATOM 16864 NH1 ARG B 528 73.996 13.397 −33.146 1.00 35.92 B N ATOM 16867 NH2 ARG B 528 74.373 14.884 −34.854 1.00 35.81 B N ATOM 16870 C ARG B 528 70.673 16.287 −30.655 1.00 33.89 B C ATOM 16871 O ARG B 528 70.950 15.705 −29.606 1.00 34.34 B O ATOM 16873 N LYS B 529 71.378 17.313 −31.127 1.00 33.28 B N ATOM 16874 CA LYS B 529 72.566 17.824 −30.436 1.00 32.69 B C ATOM 16876 CB LYS B 529 73.298 18.863 −31.294 1.00 32.75 B C ATOM 16879 CG LYS B 529 74.085 18.275 −32.452 1.00 32.66 B C ATOM 16882 CD LYS B 529 74.956 19.327 −33.120 1.00 32.31 B C ATOM 16885 CE LYS B 529 75.829 18.711 −34.200 1.00 32.91 B C ATOM 16888 NZ LYS B 529 76.857 19.660 −34.708 1.00 33.59 B N ATOM 16892 C LYS B 529 72.225 18.436 −29.079 1.00 32.13 B C ATOM 16893 O LYS B 529 72.916 18.182 −28.091 1.00 32.37 B O ATOM 16895 N ARG B 530 71.165 19.241 −29.037 1.00 31.27 B N ATOM 16896 CA ARG B 530 70.759 19.913 −27.800 1.00 30.74 B C ATOM 16898 CB ARG B 530 69.629 20.912 −28.070 1.00 30.66 B C ATOM 16901 CG ARG B 530 70.095 22.182 −28.768 1.00 30.10 B C ATOM 16904 CD ARG B 530 68.926 23.081 −29.131 1.00 28.52 B C ATOM 16907 NE ARG B 530 69.370 24.383 −29.626 1.00 26.96 B N ATOM 16909 CZ ARG B 530 68.554 25.374 −29.982 1.00 26.60 B C ATOM 16910 NH1 ARG B 530 67.234 25.224 −29.904 1.00 26.51 B N ATOM 16913 NH2 ARG B 530 69.059 26.524 −30.420 1.00 26.25 B N ATOM 16916 C ARG B 530 70.346 18.918 −26.716 1.00 30.41 B C ATOM 16917 O ARG B 530 70.684 19.097 −25.546 1.00 30.43 B O ATOM 16919 N VAL B 531 69.626 17.871 −27.110 1.00 30.03 B N ATOM 16920 CA VAL B 531 69.278 16.784 −26.191 1.00 29.78 B C ATOM 16922 CB VAL B 531 68.275 15.782 −26.834 1.00 30.01 B C ATOM 16924 CG1 VAL B 531 68.603 14.335 −26.458 1.00 30.16 B C ATOM 16928 CG2 VAL B 531 66.841 16.141 −26.447 1.00 29.98 B C ATOM 16932 C VAL B 531 70.530 16.052 −25.694 1.00 29.45 B C ATOM 16933 O VAL B 531 70.578 15.616 −24.543 1.00 29.37 B O ATOM 16935 N LEU B 532 71.536 15.927 −26.559 1.00 29.15 B N ATOM 16936 CA LEU B 532 72.822 15.331 −26.167 1.00 28.66 B C ATOM 16938 CB LEU B 532 73.687 14.993 −27.391 1.00 28.54 B C ATOM 16941 CG LEU B 532 73.627 13.537 −27.858 1.00 29.13 B C ATOM 16943 CD1 LEU B 532 72.216 13.153 −28.293 1.00 29.00 B C ATOM 16947 CD2 LEU B 532 74.630 13.293 −28.983 1.00 29.97 B C ATOM 16951 C LEU B 532 73.602 16.232 −25.208 1.00 28.00 B C ATOM 16952 O LEU B 532 74.158 15.751 −24.220 1.00 28.07 B O ATOM 16954 N SER B 533 73.632 17.532 −25.500 1.00 26.92 B N ATOM 16955 CA SER B 533 74.369 18.495 −24.679 1.00 26.09 B C ATOM 16957 CB SER B 533 74.469 19.844 −25.392 1.00 26.14 B C ATOM 16960 OG SER B 533 73.243 20.553 −25.320 1.00 26.63 B O ATOM 16962 C SER B 533 73.722 18.697 −23.311 1.00 25.29 B C ATOM 16963 O SER B 533 74.420 18.822 −22.303 1.00 25.77 B O ATOM 16965 N VAL B 534 72.392 18.729 −23.284 1.00 24.07 B N ATOM 16966 CA VAL B 534 71.643 19.035 −22.065 1.00 23.05 B C ATOM 16968 CB VAL B 534 70.265 19.652 −22.401 1.00 22.97 B C ATOM 16970 CG1 VAL B 534 69.412 19.793 −21.152 1.00 23.85 B C ATOM 16974 CG2 VAL B 534 70.448 21.003 −23.069 1.00 21.88 B C ATOM 16978 C VAL B 534 71.462 17.820 −21.153 1.00 22.17 B C ATOM 16979 O VAL B 534 71.657 17.926 −19.942 1.00 21.94 B O ATOM 16981 N ILE B 535 71.098 16.674 −21.728 1.00 21.59 B N ATOM 16982 CA ILE B 535 70.783 15.471 −20.938 1.00 20.91 B C ATOM 16984 CB ILE B 535 69.589 14.673 −21.539 1.00 20.66 B C ATOM 16986 CG1 ILE B 535 68.343 15.558 −21.675 1.00 19.60 B C ATOM 16989 CD1 ILE B 535 67.826 16.119 −20.364 1.00 17.67 B C ATOM 16993 CG2 ILE B 535 69.271 13.457 −20.680 1.00 19.45 B C ATOM 16997 C ILE B 535 71.972 14.519 −20.762 1.00 20.28 B C ATOM 16998 O ILE B 535 72.342 14.203 −19.633 1.00 19.52 B O ATOM 17000 N THR B 536 72.561 14.061 −21.866 1.00 20.21 B N ATOM 17001 CA THR B 536 73.580 13.003 −21.806 1.00 20.57 B C ATOM 17003 CB THR B 536 73.444 12.009 −22.988 1.00 20.61 B C ATOM 17005 OG1 THR B 536 73.670 12.688 −24.229 1.00 21.12 B O ATOM 17007 CG2 THR B 536 72.058 11.372 −22.996 1.00 20.40 B C ATOM 17011 C THR B 536 75.025 13.520 −21.730 1.00 20.49 B C ATOM 17012 O THR B 536 75.658 13.438 −20.677 1.00 20.27 B O ATOM 17014 N GLU B 537 75.541 14.045 −22.838 1.00 20.64 B N ATOM 17015 CA GLU B 537 76.956 14.423 −22.932 1.00 21.04 B C ATOM 17017 CB GLU B 537 77.330 14.745 −24.384 1.00 21.51 B C ATOM 17020 CG GLU B 537 77.292 13.537 −25.324 1.00 22.54 B C ATOM 17023 CD GLU B 537 77.568 13.898 −26.780 1.00 23.27 B C ATOM 17024 OE1 GLU B 537 78.095 13.035 −27.516 1.00 21.98 B O ATOM 17025 OE2 GLU B 537 77.257 15.038 −27.189 1.00 24.15 B O ATOM 17026 C GLU B 537 77.311 15.617 −22.031 1.00 20.83 B C ATOM 17027 O GLU B 537 76.737 16.700 −22.187 1.00 20.87 B O ATOM 17029 N PRO B 538 78.272 15.433 −21.099 1.00 20.36 B N ATOM 17030 CA PRO B 538 78.649 16.551 −20.233 1.00 19.96 B C ATOM 17032 CB PRO B 538 79.456 15.883 −19.104 1.00 19.93 B C ATOM 17035 CG PRO B 538 79.623 14.441 −19.482 1.00 19.71 B C ATOM 17038 CD PRO B 538 79.135 14.258 −20.878 1.00 20.30 B C ATOM 17041 C PRO B 538 79.501 17.592 −20.943 1.00 19.59 B C ATOM 17042 O PRO B 538 79.934 17.380 −22.077 1.00 19.30 B O ATOM 17043 N ILE B 539 79.728 18.715 −20.272 1.00 19.52 B N ATOM 17044 CA ILE B 539 80.663 19.715 −20.763 1.00 20.00 B C ATOM 17046 CB ILE B 539 80.524 21.056 −20.008 1.00 20.22 B C ATOM 17048 CG1 ILE B 539 79.134 21.656 −20.230 1.00 19.71 B C ATOM 17051 CD1 ILE B 539 78.919 22.967 −19.510 1.00 19.23 B C ATOM 17055 CG2 ILE B 539 81.594 22.051 −20.464 1.00 19.98 B C ATOM 17059 C ILE B 539 82.072 19.168 −20.569 1.00 20.32 B C ATOM 17060 O ILE B 539 82.372 18.577 −19.530 1.00 20.46 B O ATOM 17062 N LEU B 540 82.928 19.353 −21.569 1.00 20.70 B N ATOM 17063 CA LEU B 540 84.317 18.904 −21.480 1.00 21.15 B C ATOM 17065 CB LEU B 540 85.103 19.328 −22.725 1.00 21.14 B C ATOM 17068 CG LEU B 540 84.665 18.725 −24.065 1.00 20.69 B C ATOM 17070 CD1 LEU B 540 85.271 19.506 −25.229 1.00 19.34 B C ATOM 17074 CD2 LEU B 540 85.032 17.246 −24.140 1.00 17.98 B C ATOM 17078 C LEU B 540 84.957 19.510 −20.230 1.00 21.63 B C ATOM 17079 O LEU B 540 84.734 20.687 −19.939 1.00 22.38 B O ATOM 17081 N PRO B 541 85.746 18.716 −19.481 1.00 21.69 B N ATOM 17082 CA PRO B 541 86.321 19.215 −18.224 1.00 21.85 B C ATOM 17084 CB PRO B 541 87.149 18.027 −17.712 1.00 21.79 B C ATOM 17087 CG PRO B 541 87.361 17.154 −18.895 1.00 22.13 B C ATOM 17090 CD PRO B 541 86.153 17.327 −19.754 1.00 21.68 B C ATOM 17093 C PRO B 541 87.205 20.452 −18.389 1.00 22.14 B C ATOM 17094 O PRO B 541 87.704 20.723 −19.480 1.00 22.12 B O ATOM 17095 N PHE B 542 87.385 21.191 −17.298 1.00 22.72 B N ATOM 17096 CA PHE B 542 88.184 22.414 −17.305 1.00 23.32 B C ATOM 17098 CB PHE B 542 87.783 23.298 −16.120 1.00 23.32 B C ATOM 17101 CG PHE B 542 88.756 24.402 −15.833 1.00 24.16 B C ATOM 17102 CD1 PHE B 542 89.494 24.409 −14.654 1.00 24.68 B C ATOM 17104 CE1 PHE B 542 90.398 25.425 −14.389 1.00 24.06 B C ATOM 17106 CZ PHE B 542 90.580 26.443 −15.309 1.00 24.14 B C ATOM 17108 CE2 PHE B 542 89.853 26.444 −16.491 1.00 24.52 B C ATOM 17110 CD2 PHE B 542 88.949 25.426 −16.748 1.00 24.49 B C ATOM 17112 C PHE B 542 89.688 22.104 −17.261 1.00 23.94 B C ATOM 17113 O PHE B 542 90.167 21.469 −16.320 1.00 23.65 B O ATOM 17115 N GLU B 543 90.421 22.563 −18.279 1.00 24.84 B N ATOM 17116 CA GLU B 543 91.874 22.344 −18.380 1.00 25.76 B C ATOM 17118 CB GLU B 543 92.235 21.696 −19.728 1.00 25.79 B C ATOM 17121 CG GLU B 543 92.464 20.182 −19.672 1.00 25.69 B C ATOM 17124 CD GLU B 543 93.330 19.661 −20.818 1.00 25.14 B C ATOM 17125 OE1 GLU B 543 93.398 20.313 −21.883 1.00 24.79 B O ATOM 17126 OE2 GLU B 543 93.945 18.587 −20.650 1.00 23.90 B O ATOM 17127 C GLU B 543 92.683 23.634 −18.213 1.00 26.66 B C ATOM 17128 O GLU B 543 92.137 24.738 −18.259 1.00 26.93 B O ATOM 17130 N ARG B 544 93.992 23.470 −18.017 1.00 27.44 B N ATOM 17131 CA ARG B 544 94.937 24.585 −17.945 1.00 28.02 B C ATOM 17133 CB ARG B 544 95.430 24.787 −16.509 1.00 28.24 B C ATOM 17136 CG ARG B 544 94.332 25.114 −15.508 1.00 29.37 B C ATOM 17139 CD ARG B 544 94.881 25.278 −14.094 1.00 31.23 B C ATOM 17142 NE ARG B 544 93.858 25.011 −13.080 1.00 33.21 B N ATOM 17144 CZ ARG B 544 93.577 23.811 −12.563 1.00 34.35 B C ATOM 17145 NH1 ARG B 544 94.242 22.720 −12.943 1.00 34.25 B N ATOM 17148 NH2 ARG B 544 92.616 23.700 −11.649 1.00 34.18 B N ATOM 17151 C ARG B 544 96.124 24.303 −18.862 1.00 28.26 B C ATOM 17152 O ARG B 544 96.881 25.207 −19.220 1.00 28.64 B O ATOM 17154 O HOH C 1 49.400 −35.729 6.838 1.00 2.00 O ATOM 17157 O HOH C 2 77.843 −36.939 −9.130 1.00 2.00 O ATOM 17160 O HOH C 3 55.726 −22.590 −6.230 1.00 19.51 O ATOM 17163 O HOH C 4 37.476 −22.187 −17.999 1.00 2.00 O

Example 9 Expression and Purification of IspS-T536F

Expression of 6×His-Tagged IspS-T536F

N-terminally 6×His-tagged IspS-T536F was expressed and purified from strain DW363. The growth procedure is suitable for histidine tagged enzymes expressed in BL21(λDE3)pLysS cells. A 10 ml overnight culture was prepared for each 1 L of planned growth. The appropriate antibiotics (50 mg/ml kanamycin, 50 mg/ml chloramphenicol) were added to 10 ml of LB medium in a 25 ml flask which was inoculated with 1 colony from a fresh plate of cells or directly from glycerol frozen cell stock. Cultures were grown at 30° C. overnight with shaking at ˜220 rpm. Day cultures were prepared in 1 liter of LB medium with appropriate antibiotics for each culture. Each 1 L day culture was inoculated with 10 ml of overnight culture and grown at 30-37° C. with shaking at ˜220 rpm until the OD₆₀₀ reached ˜0.4-0.6. Day cultures were then induced with 400 μM IPTG and allowed to continue growing at 30° C. with shaking at 220 rpm for ˜5-6 hours. Cells were then harvested by centrifugation at 10,000×g for 10 min, 4° C. Following Harvest, cells were used directly or stored at −80° C. until ready to process.

Purification of 6×His-Tagged IspS-T536F

For purification of histidine tagged enzymes from BL21(λDE3)pLysS cells, cells were gently resuspended in fresh Lysis buffer (Lysis buffer: Ni wash buffer+0.5 mM PMST, 0.01% Tween-20, 1 mg/ml lysozyme, 0.2 mg/ml DNaseI; Ni wash buffer: 50 mM NaH₂PO₄, 300 mM NaCl, 20 mM Imidazole, pH 8.0). Approximately 40-50 ml of lysis buffer was used per 1 L of cell pellet. Cells were then incubated on ice for approximately 30 min. The cell suspension was then lysed fully by passing 2-3 times through a french pressure cell (large french press cell at 1200 psi/High setting) until lysate started to look clear. A sample of the lysate was saved for activity assay and gel analysis (˜100 μl). The lysate was then clarified by centrifuging the lysate at 30,000×g for 30 min, 4° C. in a Sorvall Discovery 90SE ultracentrifuge. The supernatant was removed and retained. A sample of the “clarified lysate” was saved for activity assay and gel analysis (˜100 μl).

The clarified lysate was run over HisTrap HP columns (GE healthcare) using a gradient from 0-100% Ni buffer B. Following loading of the lysate on the column, the column was washed with Ni wash buffer (50 mM NaH₂PO₄, 300 mm NaCl, 20 mM imidazole, ph 8.0). The his-tagged IspS was then eluted from the column using a gradient from 0-100% Ni elution buffer (50 mM NaH₂PO₄, 300 mM NaCl, 500 mM imidazole, ph 8.0) and fractions containing the his-tagged IspS were collected. The column was then washed with Ni stripping buffer (20 mM NaH2PO4, 0.5 m NaCl, 50 mM EDTA, ph 7.4). Samples were then analyzed by SDS-PAGE gel (4-12% gel NUPAGE, Invitrogen) according to manufacturer's directions. Desired fractions were concentrated on spin filters (Vivaspin-20, Sartoris,) and then desalted over a Hi Prep 26/10 Desalting column (GE healthcare) packed with Sephadex G25 resin. The G-25 buffer consisted of 50 mM HEPES, 50 mM NaCl, and 1 mM DTT, pH 7.4. Fractions were then analyzed and concentrated. The samples were then stored at −80° C.

TEV Cleavage (IspS-T536F from Strains DW363)

Strain DW363 is described in Example 6. Digestion was performed with TurboTEV Protease from Eton Bioscience Inc. One unit of TurboTEV per 10 μg of purified protein was used. The digest was performed at 4° C. overnight. Samples were passed through another Ni column equilibrated in the Ni buffer to remove uncleaved enzyme, tag, TurboTEV protease (which is also tagged), and impurities. The Ni column pass though and washes were analyzed using SDS-PAGE gel (NUPAGE, Invitrogen; FIG. 54) and DMAPP activity assays. Samples containing pure enzyme were pooled and desalted into 50 mM NaCl pH 7.4 buffer containing 1 mM DTT and stored at −80° C.

Expression Levels of IspS Variants

Small Scale Expression of 6×His-Tagged IspS Variants

N-terminally 6×His-tagged wild type IspS, IspS-L494P, and IspS-T536F were expressed and purified from strains MD09-167, DW399, and DW363, respectively. The growth procedure is suitable for histidine tagged enzymes expressed in BL21(λDE3)pLysS cells. A 3 ml of overnight culture was prepared for each 100 mL of planned growth. The appropriate antibiotics (50 mg/ml kanamycin, 25 mg/ml chloramphenicol) were added to 3 ml of LB medium in a 10 ml glass tube and was inoculated with 1 colony from a fresh plate of cells or directly from glycerol frozen cell stock. Cultures were grown at 30° C. overnight with shaking at ˜220 rpm. Day cultures were prepared in 100 mL of LB medium with appropriate antibiotics for each culture. Each 100 mL day culture was inoculated with 50 μl of overnight culture and grown at 37° C. with shaking at ˜220 rpm until the OD₆₀₀ reached ˜0.4-0.6. Day cultures were then induced with 400 μM IPTG and allowed to continue growing at 30° C. with shaking at 220 rpm for ˜5-6 hours. Cells were then harvested by centrifugation at 10,000×g for 10 min, 4° C. Following Harvest, cells were used directly or stored at −80° C. until ready to process.

Purification of 6×His-Tagged IspS Variants Expressed in Small Scale

For purification of histidine tagged enzymes from BL21(λDE3)pLysS cells, cells were gently resuspended in fresh Lysis buffer (Lysis buffer: Ni wash buffer+0.5 mM PMST, 0.01% Tween-20, 1 mg/ml lysozyme, 0.2 mg/ml DNaseI; Ni wash buffer: 50 mM NaH₂PO₄, 300 mM NaCl, 20 mM Imidazole, pH 8.0). Approximately 3 ml of lysis buffer was used per 5 mL of cell pellet. Cells were then incubated on ice for approximately 30 min. The cell suspension was then lysed fully by passing 2-3 times through a french pressure cell (small french press cell at 850 psi/Low setting) until lysate started to look clear. A sample of the lysate was saved for activity assay and gel analysis (˜100 μl). The lysate was then clarified by centrifuging the lysate at 30,000×g for 30 min, 4° C. in a Sorvall Discovery 90SE ultracentrifuge. The supernatant was removed and retained. A sample of the “clarified lysate” was saved for activity assay and gel analysis (˜100 μl).

A 20 mL disposable column containing 0.5 mL Ni Sepharose 6 Fast Flow resin (Amersham) was pre equilibrated with 10 mL of Ni wash buffer. Protein in the clarified lysate was added to the column and shaken gently for 60 min at 4° C. in order to bind the tagged protein. The protein was then eluted with 2.5 mL Ni elution buffer. A sample of the eluate was saved for activity assay and gel analysis (˜100 μl).

To buffer exchange the protein into a buffer suitable for protein assays and storage, a PD-10 column (GE Healthcare) was equilibrated with 25 mL PD-10 buffer (50 mM HEPES, 0.05 M NaCl, pH 7.4). Protein was loaded onto the PD-10 column and eluted with 3.5 mL of PD-10 buffer. The eluate was then analyzed by absorbance at 280 nm and SDS-PAGE gel and the samples were stored at −80° C.

Analysis of the yield of purified wild type IspS compared to IspS-L494P, and IspS-T536F suggests that both IspS-L494P and IspS-T536F are expressed at higher levels than the wild type protein (Table 9, FIG. 55).

Differential Scanning Calorimetry

Excessive heat capacity curves were measured using an ultrasensitive scanning high-throughput microcalorimeter, VP-Cap DSC (MicroCal, Inc., Northampton, Mass.). The standard procedure for Differential Scanning calorimetry (DSC) measurements and the theory of the technique is previously published (Freire, E. (1995) Differential Scanning calorimetry Methods. Mol. Biol. 41, 191-218). Approximately 500 μL of 0.5 mg/ml IspS (from strain MD09-167) or variant IspS-L494P (from strain DW399) and IspS-T536F (from strain DW363) (in the absence or presence of 5 mM sodium pyrophosphate) were scanned over a 30-100° C. temperature range. The same sample was then re-scanned to check the reversibility of the process. For IspS the thermal unfolding process was irreversible. The buffer used was 50 mM HEPES, 5 mM MgCl₂, pH 7.4, with and without 5 mM sodium pyrophosphate. Sodium pyrophosphate was included for its ability to function as a substrate analog. A 200° C./hr scan rate was used to minimize any artifacts that may result from aggregation. The thermal midpoint (Tm) of the DSC curves was used as an indicator of the thermal stability. The thermal melting curves and the melting points for the wild type IspS and variants are shown in FIGS. 56 (buffer only) and 57 (with 5 mM sodium pyrophosphate).

The thermal unfolding for the IspS variants IspS-L494P and IspS-T536F in buffer demonstrates a considerable increase in the melting points for the variants when compared to that for the wild type. In buffer alone, the wild type IspS has a thermal melting point of 58.3° C. while the Tm's for IspS-L494P and IspS-T536F are 60.4° C. and 62.1° C., respectively. Thus, the substitution of L494 with P results in an increase in the Tm of 2.1° C., and the substitution of T536 with F results in an increase in the Tm of 3.8° C.

In the presence of sodium pyrophosphate, the wild type IspS and IspS variants all exhibit a decrease in melting point compared to analysis in buffer alone. When wild type IspS and the variants were thermally-unfolded in the presence of 5 mM sodium pyrophosphate, wild type IspS has a thermal melting point of 54.7° C., while the Tm's for IspS-L494P and IspS-T536F are 57.0° C. and 59.4° C., respectively. Thus, the substitution of L494 with P results in an increase in the Tm of 2.3° C., and the substitution of T536 with F results in an increase in the Tm of 4.7° C. The change in the shape of the DSC traces in the presence of substrate analog and the decrease in the Tm for the proteins could be the result of aggregation or represent a structure or conformational change of the protein upon complexation of the substrate analog. In addition, there is an exothermic peak. Nonetheless, the changes in the Tm's are fairly consistent with those for buffer alone.

Isoprene Synthase Activity vs Temperature

The activity of wild type IspS and variants IspS-L494P and IspS-T536F was measured across a spectrum of temperatures. Individual DMAPP assays were performed at 5° C. intervals from 25° C. to 80° C. by incubating the vials in a pre-heated water bath.

Isoprene Synthase DMAPP Assay

The following reaction mixture was used for the DMAPP assay: 25 μL purified protein, 5 μL MgCl2 (1 M), 5 μL DMAPP (100 mM), and 65 μL 100 mM Tris pH 8, 100 mM NaCl for a total volume of 100 μL. The reaction is performed at the specified temperature for 15 minutes in a gas tight 1.8 mL GC tube. Reactions are terminated by the addition of 100 μL 500 mM EDTA (pH 8). The amount of isoprene produced was measured by GC/MS.

The analysis was performed using an Agilent 6890 GC/MS system interfaced with a CTC Analytics CombiPAL autosampler operating in headspace mode. An Agilent HP-5MS GC/MS column (30 m×0.25 mm; 0.25 μm film thickness) was used for separation of analytes. The sampler was set up to inject 500 μL of headspace gas. The GC/MS method utilized helium as the carrier gas at a flow of 1 ml/min. The injection port was held at 250° C. with a split ratio of 50:1. The oven temperature was held at 37° C. for the 2 min duration of the analysis. The Agilent 5793N mass selective detector was run in single ion monitoring (SIM) mode on m/z 67. The detector was switched off from 1.4 to 1.7 minutes to allow the elution of permanent gases. Under these conditions isoprene (2-methyl-1,3-butadiene) was observed to elute at 1.78 minutes. A calibration table was used to quantify the absolute amount of isoprene and was found to be linear from 1 μg/L to 200 μg/L. The limit of detection was estimated to be 50-100 ng/L using this method.

The temperature activity ratios for wild type IspS and variants IspS-L494P and IspS-T536F are plotted in FIG. 58. The IspS-T536F variant shifts the curve both upwards and to the right, suggesting that it has increased activity and thermostability as compared to wild type IspS and IspS-L494P. The activity and thermostability benefits of the T536F variant may be attributable to the replacement of a polar amino acid residue (threonine) with a large, hydrophobic residue (phenylalanine). FIG. 59 shows that at the 536 position, hydrophobic residues such as isoleucine, valine, and phenylalanine are common to many terpene synthase enzymes. It is therefore possible that the T536F mutation serves to remove polarity and introduce a more hydrophobic local region, and this change leads to the observed benefits in catalytic efficiency.

TABLE 9 Relative yield of purified IspS-L494P and IspS-T536F compared to wild type IspS Protein Relative Yield Wild type IspS 1 IspS-L494P 1.3 IspS-T536F 1.9 

We claim:
 1. An isolated host cell comprising an isoprene synthase variant produced by: a) identifying hydrophobic amino acid residues on the surface of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the surface amino acids of said isoprene synthase to produce an isoprene synthase variant; and c) identifying said isoprene synthase variants with substitutions that improve activity, expression or stability of the isoprene synthase, wherein said isoprene synthase variant comprises one or more amino acid substitutions at a hydrophobic surface amino acid position corresponding to a hydrophobic surface amino acid position of SEQ ID NO: 45 selected from the group I28, V30, L130, G153, L469, L303 and L494; and wherein said isoprene synthase variant has improved activity, expression or stability of the isoprene synthase compared to an isoprene synthase without said one or more amino acid substitutions.
 2. An isolated host cell comprising an isoprene synthase variant, wherein the isoprene synthase variant comprises one or more amino acid substitutions at a hydrophobic surface amino acid position corresponding to a hydrophobic surface amino acid position of SEQ ID NO: 45 selected from the group I28, V30, L130, G153, L469, L303 and L494 and wherein said isoprene synthase variant has improved activity, expression and/or stability as compared to an isoprene synthase without said one or more amino acid substitutions.
 3. The isolated host cell of claim 2 wherein the variant comprises one or more substitutions selected from the group consisting of: I28W, I28T, I28R, I28Y, V30K, L130W, L130K, L130S, L130Y, L130R, L130V, L130I, L130E, L130D, G153K, G153H, G153L, G153W, L303I, L469A, L469Q, L494P, L494C, L494I, L494V, L494S, L494G, and L494D.
 4. The isolated host cell of claim 2, wherein the cell is a gram-positive bacterial cell, gram-negative bacterial cell, filamentous fungal cell, or yeast cell.
 5. The isolated host cell of claim 4, wherein the bacterial cell is selected from the group consisting of E. coli, P. citrea, B. subtilis, B. licheniformis, B. lentus, B. brevis, B. stearothermophilus, B. alkalophilus, B. amyloliquefaciens, B. clausii, B. halodurans, B. megaterium, B. coagulans, B. circulans, B. lautus, B. thuringiensis, S. albus, S. lividans, S. coelicolor, S. griseus, Pseudomonas sp., and P. alcaligenes cells.
 6. The host cell of claim 4 wherein the cell is selected from the group consisting of Escherichia sp. (E. coli), Saccharomyces sp. (S. cerevisiae), Panteoa sp. (P. citrea), Bacillus sp. (B. subtilis), Yarrowia sp. (Y. lipolytica), and Trichoderma (T. reesei).
 7. The isolated host cell of claim 2, wherein the host cell further comprises a heterologous or native nucleic acid encoding an isopentenyl-diphosphate delta-isomerase (IDI) polypeptide and/or a heterologous or native nucleic acid encoding a 1-Deoxyxylulose-5-phosphate synthase (DXS) polypeptide, optionally in combination with the native 1-deoxy-D-xylulose-5-phosphate (DXP) pathway.
 8. The isolated host cell of claim 2, wherein the host cell further comprises one or more nucleic acids encoding an IDI polypeptide and a DXS polypeptide.
 9. The isolated host cell of claim 2, wherein the host cell comprises one vector encoding the isoprene synthase variant, the IDI polypeptide, and the DXS polypeptide.
 10. The isolated host cell of claim 9 wherein the host cell further comprises a heterologous nucleic acid encoding a mevalonate (MVA) pathway polypeptide selected from the group consisting of an MVA pathway polypeptide from Saccharomyces cerevisiae and Enterococcus faecalis.
 11. The isolated host cell of claim 2 wherein the host cell further comprises one or more nucleic acids encoding an MVA pathway polypeptide and a DXS polypeptide and wherein one vector encodes the isoprene synthase variant, the MVA pathway polypeptide, and the DXS polypeptide.
 12. The isolated host cell of claim 2 wherein the host cell further comprises one or more nucleic acids encoding a DXS polypeptide, an IDI polypeptide, or one or more of the rest of the DXP pathway polypeptides, and a MVA pathway polypeptide.
 13. The isolated host cell of claim 2, wherein the host cell further comprises one or more heterologous nucleic acid(s) encoding an MVA pathway polypeptide.
 14. The isolated host cell of claim 13, wherein the host cell further comprises one or more nucleic acids encoding an IDI polypeptide.
 15. A method of producing isoprene, comprising: (a) providing a host cell of any one of claims 1, 2 and 3-14; and (b) culturing the host cell under conditions suitable for producing isoprene. 